Tesis sobre el tema "PCDF"
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Yang, Yun. "Temperature dependent PCDD/PCDF product distributions from phenols". Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/20182.
Texto completoMoore, Paul 1962. "The Analysis of PCDD and PCDF Emissions from the Cofiring of Densified Refuse Derived Fuel and Coal". Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc330690/.
Texto completoWeber, P. [Verfasser]. "Der Chlortransfer bei der Bildung von polychlorierten organischen Spurenstoffen (PCDD/PCDF) in industriellen thermischen Prozessen (Müllverbrennung) / P. Weber". Karlsruhe : KIT-Bibliothek, 2000. http://d-nb.info/1198219823/34.
Texto completoStark, Marie Luise [Verfasser]. "Transfer von Dioxinen (PCDD), Furanen (PCDF) und polychlorierten Biphenylen (PCB) aus dem Futter in ausgewählte Gewebe wachsender Schafe / Marie Luise Stark". Berlin : Freie Universität Berlin, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:188-refubium-31051-8.
Texto completoQuinn, Laura Penelope. "Persistent organic pollutants (POPs) in soil associated with an active incinerator in Potchefstroom, South Africa / L.P. Quinn". Thesis, North-West University, 2005. http://hdl.handle.net/10394/1013.
Texto completoThesis (M. Environmental Science)--North-West University, Potchefstroom Campus, 2006.
Gaus, Caroline y n/a. "Dioxins in the Marine Environment: Sources, Pathways and Fate of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Queensland, Australia". Griffith University. School of Public Health, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030624.144111.
Texto completoGaus, Caroline. "Dioxins in the Marine Environment: Sources, Pathways and Fate of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Queensland, Australia". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367537.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Public Health
Faculty of Health Sciences
Full Text
Lundin, Lisa. "Formation and degradation of PCDD/F in waste incineration ashes". Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1395.
Texto completoGao, Qiuju. "Dioxins and dioxin-like compounds in thermochemical conversion of biomass : formation, distribution and fingerprints". Doctoral thesis, Umeå universitet, Kemiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118861.
Texto completoSwiegelaar, Caitlin Reneé. "The effect of different sample preparatory protocols on the induction of the aryl hydrocarbon receptor (AhR) in the H4IIE-luc reporter gene bio-assay / Caitlin Reneé Swiegelaar". Thesis, North-West University, 2012. http://hdl.handle.net/10394/9702.
Texto completoThesis (MSc (Environmental Sciences))--North-West University, Potchefstroom Campus, 2013.
Weidemann, Eva. "Waste incineration residues : Persistent organic pollutants in flue gas and fly ash from waste incineration". Doctoral thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92765.
Texto completoFörbränning av hushållssopor är en vanlig metod för att hantera ett växande avfallsproblem. Metoden har flera fördelar, såsom minskning av volym och vikt, sterilisering och energiåtervinning. Sopförbränning har dock vissa nackdelar och det mest debatterade är sannolikt utsläpp av persistenta organiska föroreningar (POPs) som polyklorerad dibensofuran (PCDF), dibenso-p-dioxin (PCDD), bifenyl (PCB) och naftalen (PCN). Det finns totalt 210 PCDF- och PCDD- kongener, med mellan ett till åtta klor på kolskelettet, varav 17 är giftiga med hormonstörande och cancerframkallande egenskaper. Även tolv av totalt 209 PCB-kongener samt minst två av totalt 75 PCN-kongener uppvisar liknande egenskaper. Dessa klorerade organiska föroreningar bildas då rökgaserna kyls ner i sopförbränningsanläggningarna och avlägsnas från rökgaserna med hjälp av filter och hamnar i flygaskan. Denna avhandling handlar om bildning och nedbrytning av POPs i sopförbränningsrelaterade processer. Den första artikeln är en fallstudie där PCDD bildas i filtren i en fullskalig sopförbränningsanläggning. Bildningen ledde till förhöjda halter organiska föroreningar i rökgaserna, vilket ledde till ökade utsläpp. Den funna bildningsvägen för PCDD i filtren befanns sannolikt bero på kondensation av klorfenoler på filterytorna. Den andra artikeln är en valideringsstudie av en kylprob avsedd att användas vid rökgasprovtagning vid hög temperatur (> 450 °C) för att undvika bildning av POPs under provtagningen. Studien bekräftade att majoriteten av PCDF- och PCDD- bildning i rökgaser från sopförbränning sker vid temperaturer under 600 °C. I den tredje artikeln berättas om behandling av tre olika flygaskor från olika sopförbränningsanläggningar. Askorna behandlades vid 400 °C i inert atmosfär i både en roterugn och i förseglade ampuller. De resulterande koncentrationerna, kloreringsgraderna och kongenprofilerna av de organiska föroreningarna jämfördes. Likheter hittades mellan PCDF och PCN, medan PCDD och PCB betedde sig på ett annat sätt. Studien fann också att PCDF kongenprofiler i aska som behandlats i roterugnen liknade varandra, oberoende av askornas sammansättning, vilket tyder på en liknande bildningsväg. För den fjärde artikeln, genomfördes ytkarakterisering (SEM, EDX, XPS och XRD) på de tre flygaskorna från artikel tre som sedan hettades upp från 30 °C till 900 °C i vacuum. Det som frigjordes på grund av uppvärmningen samt nedbrytningsprodukter från askorna studerades med hjälp av masspektrometri och infraröd spektroskopi. Studien fann att de gaser som frigjordes när temperaturen ökade skilde mellan askorna, beroende på deras sammansättning. Studien fann också att när aska dopad med isotopmärkt PCDF och PCDD utsattes för samma behandling, frigjordes PCDD vid lägre temperatur än PCDF. Denna avhandling berör flera aspekter av problematiken kring klorerade organiska föroreningar som bildas vid sopförbränning, från provtagning till hur man ska hantera flygaskan. Avhandlingen belyser även olika typer av bildning och nedbrytning av POPs i varma processer kopplade till sopförbränning.
Prange, Joelle y n/a. "Origin of Dioxins in Queensland: Investigations into the Distribution and Sources of Polychlorinated Dibenzo-P-Dioxins in the Queensland Terrestrial Environment". Griffith University. School of Public Health, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040615.161651.
Texto completoPrange, Joelle. "Origin of Dioxins in Queensland: Investigations into the Distribution and Sources of Polychlorinated Dibenzo-P-Dioxins in the Queensland Terrestrial Environment". Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367289.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Public Health
Full Text
Aurell, Johanna. "Effects of Varying Combustion Conditions on PCDD/F Formation". Doctoral thesis, Umeå universitet, Kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1795.
Texto completoRibeiro, Renata Esteves. "Criminologia verde : crimes ambientais no Distrito Federal". reponame:Repositório Institucional da UnB, 2018. http://repositorio.unb.br/handle/10482/31906.
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Estatísticas criminais constituem parte importante da atividade policial. A adoção de ferramentas mais adequadas a cada conjunto de dados pode fornecer informações úteis para a ação da polícia na sua função de apuração das infrações penais. Danos e problemas ambientais específicos são construídos através de processos sociais complexos, constituídos por uma combinação de fatores materiais e sociais. Diferentes escritores da criminologia verde, ramo que foca questões referentes a danos, transgressões e crimes ambientais, defendem uma abordagem mais conceitual, no sentido de alocar os debates em torno da interligação entre questões sociais e ambientais. Este trabalho tem como objetivos: i) Avaliar o cenário temporal e espacial dos registros de crimes ambientais entre os anos de 2009 e 2016; ii) verificar a influência das variáveis socioeconômicas sobre os registros de crimes ambientais, determinando se as teorias da criminologia tradicional se aplicam aos crimes ambientais estudados neste trabalho. Foi possível identificar uma desproporção entre o número de registros de tipos penais, explicada pela vasta presença de Unidades de Conservação no território do DF e pelos altos índices de infraestrutura sanitária e reduzido parque industrial. Há associações consistentes entre alguns tipos penais definidos na Lei de Crimes Ambientais (Lei no 9.605/1998) e algumas Regiões Administrativas (RA) do Distrito Federal e certas delegacias de polícia, explicadas pelas singularidades de cada área. Os registros de crimes ambientais ocorrem principalmente nas áreas urbanas. Homogeneidades e particularidades no uso do solo aparecem como fatores influenciadores na distribuição espacial. A frequente relação com as variáveis relacionadas à migração sugere uma possível aplicação da teoria da desorganização social aos crimes ambientais, refletindo a incapacidade da comunidade em se organizar em prol do controle comunitário.
Criminal statistics are an important part of police activity. The adoption of more appropriate tools for each set of data can provide useful information for police investigation of criminal offenses. Specific environmental damage and problems are built through complex social processes, made up of a combination of material and social factors. Different writers of green criminology, a branch that focuses on issues related to damages, transgressions and environmental crimes, advocate a more conceptual approach, in order to allocate debates around the interconnection between social and environmental issues. This study aims to: i) Evaluate the temporal and spatial scenario of environmental crime records between 2009 and 2016; ii) to verify the influence of the socioeconomic variables on the records of environmental crimes, determining if the theories of traditional criminology apply to the environmental crimes studied in this work. It was possible to identify a disproportion between the number of records of criminal types, explained by the vast presence of Conservation Units in the territory of the Federal District and by the high rates of sanitary infrastructure and reduced industrial park. There are consistent associations between some criminal types defined in the Environmental Crimes Law (Law 9605/1998) and some Administrative Regions (RA) of the Federal District and certain police stations, explained by the singularities of each area. Records of environmental crimes occur mainly in urban areas. Homogeneities and particularities in soil use appear as influencing factors in the spatial distribution. The frequent relationship with the variables related to migration suggests a possible application of the theory of social disorganization to environmental crimes, reflecting the inability of the community to organize in favor of community control.
Larsson, Daniel. "Mobilisation of soil-bound dioxins at an old sawmill area : Impact of excavation on groundwater levels of PCDF/PCDDs at Norrbyskär". Thesis, Umeå universitet, Kemiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124420.
Texto completoJansson, Stina. "Thermal formation and chlorination of dioxins and dioxin-like compounds". Doctoral thesis, Umeå universitet, Kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1881.
Texto completoDenna avhandling fokuserar på olika aspekter som kan bidra till en ökad förståelse av bildning av dioxiner och dioxin-lika föreningar i förbränningsprocesser. Även om utsläppen till luft från sopförbränningsanläggningar har minskat kraftigt tack vare effektiva rökgasreningsmetoder, så återstår problemet med mycket giftiga rökgasreningsprodukter (askor och filter), vilka klassificeras som farligt avfall. Det huvudsakliga syftet med arbetet bakom denna avhandling var att klarlägga bildnings- och kloreringsvägarna för dioxiner och dioxin-lika föreningar i temperaturintervallet 640-200°C i rökgaser från sopförbränning. Detta kan möjliggöra lösningar för ytterligare emissionsminskningar och en avgiftning av biprodukterna från avfallsförbränning, vilket minskar eller till och med eliminerar behovet av kostsam och riskfylld efterbehandling. Realistiska och välkontrollerade försök har utförts i en lab-skalereaktor där en artificiell hushållssopa har förbränts. En jämförelse av fyra olika temperatur- och uppehållstidsprofiler visade att bildning av polyklorerade dibenso-p-dioxiner (PCDD) och dibensofuraner (PCDF) sker snabbt och huvudsakligen inom temperaturintervallet 640-400°C. Bildningen var starkt beroende av en tillräckligt lång uppehållstid inom ett visst temperaturområde. En förlängd uppehållstid vid höga temperaturer (>450°C) resulterade i minskade halter av PCDD, vilka förhöll sig låga även senare i efterförbränningszonen. Isomermönstren av PCDD, PCDF och PCN (polyklorerade naftalener) visade alla tecken på att härröra från både klorfenolkondensation och kloreringsreaktioner. PCDD-mönstret visade tydliga indikationer på bildning från klorfenoler, och till mindre grad bildning via klorering. För PCDF var klorsubstitution i positioner angränsande till syrebryggan missgynnad, vilket bekräftades av multivariat modellering (O2PLS). Den variabel som starkast påverkade bildningen av PCDD var relativa fria energin (RΔGf). Modellerna visade på en distinkt gruppering av PCDD- och PCDF-kongenerna i två eller tre grupper för varje kloreringsgrad, och föreslås vara relaterad till sannolikheten för respektive kongen att bildas via klorfenolkondensation. Injektion av aromatiska kolstrukturer i rökgaskanalen gav upphov till skilda effekter. Injektion av naftalen ökade bildningen av monoklorerad naftalen medan resterande homologer inte verkade påverkas, sannolikt på grund av för kort uppehållstid för ytterligare klorering. Dibenso-p-dioxin spjälkades sannolikt till fenoliska fragment som klorerades och sedan återkondenserades till PCDD och PCDF, medan dibensofuran och fluoren kraftigt reducerade PCDD-koncentrationerna.
Xu, Weiguang. "Risk assessment of dietary exposure to PCDD/PCDFs, DL-PCBs and NDL-PCBs of Hong Kong residents". HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1407.
Texto completoNording, Malin. "Rapid sample preparation and bioanalytical techniques for efficient screening of organic pollutants in the environment". Doctoral thesis, Umeå universitet, Kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-842.
Texto completoDuclot, Florian. "Rôle de l'acétyltransférase PCAF dans la plasticité cérébrale physiologique et pathologique : analyse de souris PCAF knock-out". Montpellier 2, 2009. http://www.theses.fr/2009MON20244.
Texto completoFrýba, Lukáš. "Analýza alternativ odstraňování PCDD/F při spalování odpadů". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229471.
Texto completoMateo, González Francesca. "Regulació del complex ciclina A-CDK2 per l'acetilasa PCAF". Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/914.
Texto completoEn aquest treball presentem un nou mecanisme de regulació dels complexes ciclina-CDK. Concretament hem observat que els membres del complex ciclina A-CDK2 interaccionen amb l'acetilasa PCAF. Aquesta proteïna ha estat generalment considerada com a un co-activador transcripcional gràcies a la seva capacitat d'acetilar histones i activar la transcripció gènica. Tanmateix, també s'ha vist que és capaç d'acetilar proteïnes no-histones com ara p53 o MyoD, i com a conseqüència està implicada en altres funcions cel·lulars com la diferenciació o la resposta a dany al DNA. L'acetilasa PCAF s'uneix al complex ciclina A-CDK2 tot inhibint la seva activitat quinasa. A més, acetila la ciclina A, cosa que comporta la seva degradació pel sistema ubiquitina-proteasoma. PCAF també acetila CDK2 a la lisina 33, la qual es troba molt conservada a la família de les CDKs, ja que és un aminoàcid crucial per a la interacció amb l'ATP. L'acetilació de CDK2 a la lisina 33 comporta la inhibició de la seva activitat quinasa i la seva separació de la ciclina A.
En conclusió, els resultats d'aquesta tesi aporten un nou nivell de regulació dels complexes ciclina-CDK desconegut fins ara, i que cal tenir en compte com a possible mecanisme d'acció dels fàrmacs basats en compostos inhibidors de deacetilases els quals, d'altra banda, estan donant bons resultats en el tractament de malalties hematològiques i tumors sòlids.
"REGULATION OF CYCLIN A-CDK2 COMPLEX BY ACETYLATION"
TEXT:
Cell cycle proteins are regulated in different ways, being phosphorylation one of the most important and more studied mechanisms of regulation. On the other hand, acetylation is another kind of post-translational modification that was discovered in histones and initially it was associated with transcriptionally active chromatin. However, different studies indicate that acetylation can also play a role in the regulation of non-histone proteins and it has been linked to oncogenesis and cardiovascular and neurodegenerative diseases.
In this work we report that cyclin A/cdk2 complex, which is crucial for cell cycle progression during S phase, is acetylated by the acetyltransferase P/CAF. Cyclin A directly interacts with P/CAF and is acetylated at lysines 54, 68, 95 and 112. Maximal acetylation occurs simultaneously to ubiquitylation at mitosis, indicating a role of acetylation on cyclin A stability. A non-acetylatable mutant in which these lysines were substituted by arginines (cycA 4R) cannot be ubiquitylated, is more stable than cycA wild-type and arrests cell cycle at mitosis.
Increased expression of cyclin A has been detected in many types of cancers and it has a prognostic value to predict survival or early relapse. Our results indicate that acetylation is able to cause a decrease in the levels of cyclin A, suggesting that treatment with HDAC inhibitors (which potentiate acetylation in the cell) could be considered to treat this kind of tumors.
Ellis, Cameron B. "Tribopairs in Wellbore Drilling: A Study of PCD Tilting Pad Bearings in an Electric Submersible Pump". BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7233.
Texto completoPucella, Riccardo R. "Investigations on relative definability in PCF". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24036.
Texto completoLiljeroos, Tom. "Är saltglaseringsindustrin en källa till tidig organokloridförekomst?" Thesis, Halmstad University, School of Teacher Education (LUT), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2365.
Texto completoAbstract.
The levels of dioxin and comparable substances rose to a large extent in our environment during the second half of the 20'Th century. This was the result of the synthesis of, and careless usage of these substances in cooling fluids, hydraulics, pesticides etc.
Background levels of dioxins and furans in sealed samples prior to this era suggest that former sources of these substances existed.
Salt glazing is a method of adding a smooth acid resistant exterior to stoneware ceramics. The technique has been in use since the 16'Th century, maybe even earlier than that. Some sources date the origin of the technique to the 13'Th century. Salt glazed ceramics were the prime type of industrial vessels and it was extensively used for food preservation in households from the 17'Th century to the early/mid 20'Th century.
The method was/is primarily used by Germany, Great Britain, America and Sweden.
Salt glazing is a source of graphite structures from soot, and of chlorine gas. Hence, the formation of organochlorides should be able to occur.
The reports main objective is to highlight the question; “Could the salt glazing industry be one of the sources to early dioxin emissions?” Secondary objectives are to present an introduction to dioxin and comparable substances, methods of analysis and symptoms of exposure.
The salt glazing industry is much likely one of the anthropogenic sources of early PCDD/F emissions. Though emission levels seem to be quite low, due to the persistence of PCDD/F noticeable levels could have accumulated. When the Leblanc soda process (a known source of PCDD/F) was introduced in 1791, the salt glazing process had already been used for nearly three hundred years.
Sewart, Andrew Paul. "The fate and behaviour of polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls in sewage sludge : amended agricultural soils and their potential transfer into terrestrial foodchain via lactating cattle". Thesis, Lancaster University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261004.
Texto completoÅberg, Annika. "Fate and exposure assessment of PCDD/Fs at contaminated sites". Licentiate thesis, Umeå University, Chemistry, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-5717.
Texto completoPolychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzo-furans (PCDFs) belong to the most toxic compounds known to science and they are defined as Persistent Organic Pollutants (POPs) under the Stock-holm Convention. The general human exposure to PCDD/Fs is primarily through dietary intake. The importance of contaminated sites as secondary PCDD/F sources (i.e. sources that once received its contamination from a primary source) are getting increased attention. To be able to assess the risks for human exposure at PCDD/F contaminated sites, the environmen-tal distribution of PCDD/Fs and the potential mobilization between dif-ferent environmental media (e.g. food chain transfer) must be known. The primary aim of the work presented in this thesis was to investigate human exposure pathways associated with PCDD/F contaminated sites by combining field measurements and modeling. Site specific field measurements were made at a PCDD/F contaminated site in Sweden and multimedia modeling scenarios were evaluated against site specific data and national reference data.
The results show that the congener distributions in exposure media affected by contaminated soil may differ significantly from the distribu-tions found in media from reference locations. Higher chlorinated PCDD/Fs may be transferred into food chains where they contribute to a large fraction of the toxic equivalent concentration (TEQ). Ingestion of locally produced animal food may be an important exposure pathway al-ready at low or moderate PCDD/F soil concentrations. However, the con-gener composition of the source is critical for the exposure. The signifi-cance of the individual exposure routes varies depending on e.g. the spatial distribution and magnitude of the soil contamination, the pro-perties of the exposure media and the human behavior. Multimedia mo-deling can be used in risk assessments as long as model algorithms and model parameters are representative for the superhydrophobic properties of PCDD/Fs. However, selection of physical-chemical PCDD/F properties is a challenge due to large variation in reported values. For some proper-ties, data is scattered or completely lacking
Harrad, Stuart J. "Levels and sources of PCDDs and PCDFs in UK soils". Thesis, University of East Anglia, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327955.
Texto completoLI, ZHE. "Photocyclodehydrofluorination (PCDHF) –A synthetic method for fluorinated polynuclear aromatic hydrocarbons". Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1448814689.
Texto completoFlynn, Kimberly C. Grassco Colleen E. Boorom Eric W. "Paperless Contract Folder's (PCF) DoD 5015.2 certification". Monterey, Calif. : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/JAP/2010/Jun/10Jun%5FFlynn%5FJAP.pdf.
Texto completoAdvisor(s): Doelling, Michael C. ; Brinkley, Douglas E. "June 2010." "Joint applied project"--Cover. Joint authors: .Grasso, Colleen E. ; Boorom, Eric W. Description based on title screen as viewed on July 14, 2010. Author(s) subject terms: Paperless Contract Folder's (PCF) DoD 5015.2 certification Includes bibliographical references (p. 97). Also available in print.
Flynn, Kimberly C., Eric W. Boorom y Colleen E. Grasso. "Paperless Contract Folder's (PCF) DoD 5015.2 certification". Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/10522.
Texto completoThe objective of this project is to conduct an analysis of the CECOM Contracting Center's Paperless Contracting Folder program in regards to maintaining its DoD 5015.2 certification. The desired outcomes will be the creation of a File Plan and User Guide to assist with DoD 5015.2 certification.
Da, Silva Pereira Luis Miguel. "Combinatorics of Singular Cardinals and PCF structures". Paris 7, 2007. http://www.theses.fr/2007PA077100.
Texto completoThis work is centered on Shelah's PCF theory. We study the connection between the topology of PCF spaces and standard PCF theory notions. We prove a generalization of the result that says that separable PCF spaces are sequential and obtain as a corollary that there exist many sequences that have true cofinality modulo the ideal of finite sets. We prove that this corollary is optimal. We also give a topological proof of cardinal estimates previously obtained through the use of the Galvin-Hajnal norm. We study a consequence of the negation of Shelah's PCF conjecture called the Approachable Free Subset Property (AFSP). We note that AFSP is incompatible with the existence of tree-like continuous scales and prove the consistency of these scales with the largest large cardinal axioms thus establishing that AFSP is not implied by large cardinals. We study the existence of tree-like continuous scales and the negation of AFSP in several Prikry extensions of the universe
Perearnau, Garcia Anna. "lmplicacló de p27 i PCAF en la regulació de la transcripció". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/291434.
Texto completoOur group has demonstrated the direct interaction between the cyclin-CDK inhibitor p27 and the acetyltransferase PCAF. This interaction occurs between the HAT domain of PCAF and the region comprising aa 91-120 of p27. This region of p27 contains a PRD (Proline Rich Domain, 91-96aa) a characteristic protein interacting domain. In this study we found that PCAF acetylates the lysine at position 100 of p27 in vivo. The acetylation of p27 affects its stability, promoting its translocation from the nucleus to the cytoplasm early in the G1 phase, where it will be degraded (Pérez-Luna et al., 2012). PCAF acts as a transcriptional coactivator by acetylating histones, transcription factors and other proteins. On the other hand, it has been reported that p27 acts as a transcriptional regulator, basically by repressing transcription of certain target genes. Therefore, since PCAF acetylates p27, in this thesis we focus on confirming the collaboration of p27 and PCAF in the transcriptional regulation of their target genes. To pursue this goal we have identified the transcriptional programs regulated by p27 and PCAF in HCT116 cells by ChIP -seq experiments. We found that p27 and PCAF binds to different regions of the chromatin of their target genes. Once the common target genes of p27 and PCAF were identified, their expression was analyzed. We concluded that p27 and PCAF regulate the transcription of their target genes antagonistically. p27 represses and PCAF activates the expression of most of their target genes, due to its binding to transcription regulatory elements in the chromatin. p27 binds to transcription activating elements, thus inhibiting the transcription of the target gene. On the contrary, PCAF binds to transcription silencing elements, thus activating the transcription of the target gene. Finally we demonstrated the interaction of p27 and PCAF with transcription factors PAX in HCT116 cells.
Bian, Shuning. "Real-time monitoring of ultrasound and cavitation mediated drug delivery". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:e5a774a9-5b93-4862-8dd9-0614d234ff28.
Texto completoMills, Christopher Alan. "Investigations into low band-gap, semiconducting polymers". Thesis, Bangor University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340950.
Texto completoFàbrega, Bonadona Francesc. "Physiologically-Based Pharmacokinetic (Pbpk) Modeling of Pcdd/Fs and Pfass in Humans". Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/284035.
Texto completoLos modelos farmacocinéticos (PBPK) son representaciones matemáticas del cuerpo humano, que tienen como objetivo calcular la concentración de químicos en los tejidos humanos. Los modelos PBPK pueden mejorar el cálculo de riesgo para la salud humana, pero hasta el momento no han sido muy usados. Entre los compuestos ambientales más peligrosos para la salud humana destacan las dibenzo-p-dioxinas policloradas y los dibenzofuranos policlorados (PCDD/Fs) y los compuestos perfluorados (PFASs). El objetivo de la presente tesis es el desarrollo un modelo PBPK para calcular la concentración de PCDD/Fs y PFASs en tejidos humanos. Previo al desarrollo del modelo PBPK se desarrolló un índice de riesgo usando mapas auto-organizados (SOM), para calcular los compuestos ambientales más peligrosos para la salud humana. Los PFASs se encontraron entre los compuestos de más riesgo. Después se desarrolló el modelo PBPK para predecir las concentraciones de PCDD/Fs en sangre y en tejido adiposo. Los resultados finales fueron muy coincidentes con los resultados experimentales encontrados en el área de Tarragona (NE de España), y por esta razón el modelo se consideró como validado. A continuación el modelo se adaptó para calcular las concentraciones de PFASs. Para ello, primero se adaptó el modelo para PFOS y PFOA, que son los compuestos perfluorados más estudiados en la literatura, y después se extendió el modelo a otros 9 PFASs. Finalmente, se hizo un análisis de la incertidumbre del modelo PBPK, y la incertidumbre paramétrica se estudio visual y estadísticamente.
Physiologically based pharmacokinetic (PBPK) models are mathematic representations of the human body that aims to assess the time course distribution of chemicals in human tissues. PBPK models may improve the assessment of human health risk but until now were not well studied. Among the most harmful environmental pollutants for human health there are polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and perfluoroalkyl substances (PFASs). The objective of the present work is to develop a PBPK model to assess the time course concentration of PCDD/Fs and PFASs in human tissues. Previously to the PBPK model development, a ranking index was developed using self-organizing maps (SOM) to assess the most harmful environmental contaminants, being PFASs among the most harmful compounds. After that, the PBPK model was developed to assess and predict the concentration of PCDD/Fs in human blood and adipose tissue. The final outcomes were very coincident with the experimental data found in Tarragona County (NE of Spain), and the model was considered as a validated. After that, the model was adapted to assess the concentrations of PFASs. Firstly the model was developed for PFOS and PFOA, that are the most studied compounds in the research literature, and then the model was expended to 9 PFASs more. Finally the uncertainty analysis of the PBPK model was conducted, and the parametric uncertainty was visually and statistically studied.
Zhu, Cailei. "Characterization of tumor suppressing function of PCAF in esophageal squamous cell carcinoma". Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557480.
Texto completo祝彩磊 y Cailei Zhu. "Characterization of tumor suppressing function of PCAF in esophageal squamous cell carcinoma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557480.
Texto completoGreyling, Neville. "An investigation into PCF-DCF behaviour of 802.11b networks". Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4118.
Texto completoENGLISH ABSTRACT: In recent years the demand for bandwidth has dramatically increased because of new applications for data and multimedia, and wireless technology has prevailed as a prominent technology for data connectivity, especially for home, office and last mile services. As wireless communications are dependant upon spectrum availability, which is communal, this scarce commodity in communication has to be used as efficiently as possible. Some aspects of this requirement are addressed in this project. We chose the IEEE 802.11b standard for this particular investigation because of its widespread use, the vast amount of applicable literature, the variety of software simulation tools and the ease with which equipment can be obtained. The IEEE 802.11 standard specified the Point Coordination Function as the de- terministic protocol. Recently research into this aspect has stagnated, and it was the purpose of this project to investigate how existing infrastructure networks could be improved by optimising some modes of the 802.11 protocol. The investigation also hoped to determine when to change between Distributed Coordination Function (DCF) and Point Coordination Function (PCF), and to provide an adaptive protocol to do so. This thesis presents mathematical models for the operation of DCF and PCF modes, which is compared with results from a network simulator (ns2), for theoretical veri- fication. A protocol is also proposed to dynamically switch between DCF and PCF, to harness the advantages they present.
AFRIKAANSE OPSOMMING: Die afgelope paar jaar het die aanvraag na bandwydte dramaties verhoog as gevolg van nuwe toepassings vir data en multimedia, en draadlose tegnologie het voorgekom as ’n dominante tegnologie vir data konnektiwiteit, veral vir die huis, kantoor en laaste myl dienste. Omdat draadlose kommunikasie afhanklik is van spektrum beskikbaarheid, wat gemeenskaplik is, moet hierdie skaars kommoditeit in kommunikasie so effektief moontlik gebruik word. Sekere aspekte van die vereiste sal in die tesis ondersoek word. Dit is besluit om die IEEE 802.11b standard vir die spesifieke ondersoek te gebruik as gevolg van die wye toepassing, die groot hoeveelheid beskikbare literatuur, die verskeidenheid simulasie sagteware en die gemak waarmee die toerusting bekom kan word. Die IEEE 802.11 standaard spesifiseer the Punt Koordinasie Funksie (PCF) as die deterministiese protokol vir die betrokke standaard. Onlangs het navorsing oor hierdie aspek gestagneer, en dit is die doel van die projek om te ondersoek hoe bestaande infrastruktuur netwerke moontlik verbeter kan word deur optimering van sekere modusse van die 802.11 protokol. Die ondersoek hoop ook om te bepaal wanneer die oorgang van die Distrubusie Koordinasie Funksie (DCF) en Punt Ko- ordinasie Funksie sal plaasvind, en om ’n dienooreenstemmende protokol te on- twikkel. Die tesis verskaf wiskundige modelle vir die werking van die DCF en PCF modusse, wat vergelyk word met resultate uit ’n netwerk simulator (ns2), vir teoretiese ver- ifikasie. ’n Protokol word ook voorgestel om dinamies te wissel tussen DCF and PCF, om die voordele wat die protokolle verskaf te gebruik.
Er-Rhaimini, Karim. "Constructions par forcing d'espaces LCS et de structures PCF". Paris 7, 2009. http://www.theses.fr/2009PA077196.
Texto completoThis thesis is about PCF theory and arithmetic cardinal. In chapter one, we give a simple but complete proof of Shelah's Theorem trough a simplified version of PCF theory. This theorem is in itself a justification for the study of PCF structures. In chapter two, we present the rho-fimction wich was introduced by Todorcevic. This chapter is a preparation to the forcing construction in chapter three. We mainly reproduce Todorcevic's work but in a simplified version, only keeping what is strictly necessary to our purpose. Thus, the proofs are simpler and make the reading easier. In chapter three, which is the main chapter of the thesis, we first expose the theory of LCS spaces and we show a new way to force LCS spaces of height any ordinal less than omega_3. At last, we explain the link between LCS spaces ans PCF structures and the previous forcing construction allows, by a slight modification, to force PCF structures of height any ordinal less than omega_3. This result improves the previous known result which permitted to force PCF structures of height omega_2
Streiff, Gérard. "Jean Kanapa, 1921-1978 : une singulière histoire du PCF /". Paris ; Budapest ; Torino : l'Harmattan, 2001. http://catalogue.bnf.fr/ark:/12148/cb38855551c.
Texto completoDel, Rio Gomez Iliana Maria. "Reproductive outcomes in people contaminated by PCBs/PCDFs, organohalogens in the Yucheng accident". Thesis, London School of Hygiene and Tropical Medicine (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407767.
Texto completoCornea, Flavia. "Evaluation of an alternative extraction method of PCDD/Fs from flue gas samples". Thesis, Umeå universitet, Kemiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124550.
Texto completoAshour, Hassan. "Novel DNA damage induced pathways to cancer : the role of PCAF histone acetyltransferase". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/novel-dna-damage-induced-pathways-to-cancer-the-role-of-pcaf-histone-acetyltransferase(88b6b778-6ab5-49d9-8a44-1e1d49fb3caf).html.
Texto completoHess, Philipp. "The determination and environmental significance of planar aromatic compounds in the marine environment". Thesis, Robert Gordon University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388494.
Texto completoNeumann, Stefan. "Reduzierte Produkte von Halbordnungen eine Verallgemeinerung der Shelahschen pcf-Theorie /". [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960012982.
Texto completoCheng, Yao-Chiang y 鄭銚強. "Investigation of PCDD/PCDF Formation by Inhibitors in Laboratory-scale Experimental System". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/10442761798255006376.
Texto completo國立中央大學
環境工程研究所
92
Polychlorinated dibenzodioxins and dibenzofurans (PCDD/Fs) are very toxic compounds mainly emitted from municipal solid waste incinerators(MSWI). These compounds will affect human health when inhaled. Activated carbon injection (ACI) and SCR decompostition are two major end-of-pipe pollution control technologies currently used. It is proved that addition of inhibitors (such as sulfur, SO2, urea, alkaline materials) could decrease formation of dioxins. Experimental results indicate that addition of sulfur in incineration process can reduce PCDD/F formation. PCDD/F formation can be effectively reduced when S/Cl molar ratio is about 2. Dioxins decrease dramatically at SO2/HCl ratio as 0.55. The sulfur component will react with Cl2 and convent it into HCl. In addition, S or SO2 affect dioxin formation by vulcanizating phenolic precursors and catalysis metal, thus inhibiting chlorination reaction. Calcium hydroxide can reduce dioxin formation by more than 90﹪when Ca/Cl molar ratio is over 0.5. Addition of urea can also reduce PCDD/F formation about 50~87﹪when N/Cl mole ratio is about 0.1. The role of urea is to block catalysis metal and to form complex compounds with Cu and to prevent Ullmann reaction. Inhibition of dioxins formation will be the best way to reduce dioxin emissions. The cost of applying inhibitors for reducing dioxin formation is considerably lower than that of using activated carbon injection (ACI) and SCR decompostition. Adding inhibitors technology has a good potential for controling dioxins formation and emission in the future.
Liu, Chun-Hu y 劉純湖. "The PCDD/PCDF/PCB Levels in Breast Milk Samples Collected in Tainan Area". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/ps289u.
Texto completo國立成功大學
環境醫學研究所
90
Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) are broadly distributed environmental contaminants. PCDDs/PCDFs/PCBs are highly stable in the environment. They are lipophilic and can be bioaccumulated via food chain into human bodies with long half-lives of elimination. The adipose tissue, blood, and breast milk are usually analyzed for the assessment of human exposure to PCDDs/PCDFs/PCBs. Among these three types of specimen, analysis of breast milk for exposure assessment provides two specific advantages. First, the collection of breast milk is noninvasive. Second, the analytical data can be used to assess the exposure of both the mother and the infant. The objectives of the study are (1) to measure the PCDDs/PCDFs/PCBs levels in breast milk samples collected in Tainan area, and (2) to utilize these data to evaluate infant’s exposure via breast-feeding. The samples were collected from NCKU, Sin-Lau, and Chi-Mei hospitals in Tainan city. Breast milk samples were collected from 41 volunteers in these hospitals in years 2000 and 2001. Breast milk lipids were extracted by ethanol and n-hexane, followed by sulfuric acid digestion. For the analysis of 17 PCDDs/PCDFs, the extracts were fractionated with ion exchange (SCX), silica (Si), and Florisil solid phase extraction columns, and the fraction containing dioxins and furans were analyzed by gas chromatography-high resolution mass spectrometry (GC-HRMS). For the analysis of PCBs, only Florisil column fractionation was used, and 36 PCB congeners were analyzed by gas chromatography electronic capture detector (GC-ECD). The average age of the subjects in this study was 30 years (N = 37, SD = 3.6 yrs). The total concentration of 17 dioxin congeners in the breast milk was 213 �b 141 pg/g-lipid. The concentration can be expressed as 12.7 �b 8.40 pg-I-TEQ/g-lipid when the international toxic equivalences (I-TEQs) of 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (TCDD) is calculated, or 14.6 �b 9.26 pg-WHO-TEQ/g-lipid using WHO toxic equivalences (WHO-TEQs). The total concentration of 36 PCB congeners in breast milk was 96.8 �b 96.0 ng/g-lipid. The data represent these mothers’ exposure, and infants’ exposure through breast-feeding nursing can be estimated. Assuming that the breast milk intakes per day for an infant are 805 mL in the first two months after birth, 810 mL in the third month, and 925 mL from the 4th to the 6th month respectively, with an absorption efficiency of 95 %, the average infant’s dioxin/furan exposure was estimated to be 216 �b 129 pg-I-TEQ/day (or 250 �b 148 pg-WHO-TEQ/day). Due to the weight difference between boys and girls, these values translate into 34.9 �b 20.7 pg-I-TEQ/kg/day (40.5 �b 23.8 pg-WHO-TEQ/kg/ day) for boys, and 40.1 �b 23.8 pg-I-TEQ/kg/day (46.5 �b 27.3 pg-WHO-TEQ/kg/ day) for girls. Using the same model, the average infant’s exposure to 36 PCBs was estimated to be 2671 �b 2526 ng/day, or 431 �b 408 ng/kg/day for boys and 495 �b 465 ng/kg/day for girls.
Wang, Hsiao-Jou y 王曉柔. "Exposure assessment of PCDD/PCDF/Co-PCBs for workers of secondary copper smelter". Thesis, 2005. http://ndltd.ncl.edu.tw/handle/50353486686424917961.
Texto completo國立成功大學
環境醫學研究所
93
The objective of this study was to determine the concentrations of serum PCDD/F/Co-PCBs of operation workers, the concentrations of airbrone PCDD/Fs of working environment, and the relationship between serum PCDD/F/Co-PCBs levels and health index of workers in secondary copper smelting plant. The personal exposure data and time activity pattern were collected with questionnaires. And thirteen blood biochemistry examinations, immunological index and five hormones were examined. All the results were integrated to conduct the PCDD/F/Co-PCBs exposure assessment of workers. 46 blood samples and 4 air samples were collected and analyzed in this study. The highest TEQ levels of airborne PCDD/Fs was 34.8 pg WHO-TEQ/Nm3 sampled in the casting area at plant A, and lowest was in the casting area at plant B. The partitioning of gas/particle data showed the PCDD/Fs in particle phase was higher than gas phase. All workers were grouped to foreign and local workers, then local workers were grouped to high and low-level groups by the median of serum PCDD/Fs (29.5 pg WHO98-TEQDF/g lipid). The average serum PCDD/F/Co-PCBs levels in high, low-level and foreign groups were 41.0、20.9 and 20.4 pg-WHO-TEQ/g-lipid respectively. The TEQ levels of serum PCDD/F/Co-PCBs of all workers (28.6 pg WHO98-TEQDF/g lipid)was higher than that of general populations in Taiwan. Besides the abnormal rates of glucose in low-level group and GGT in foreign group were marginally significant lower than the high-level group, there were no significant differences of blood biochemistry, hormone, and immunological index among three groups. The dominating homologue of PCDD/Fs in blood and air samples are both PeCDFs and HxCDFs, it meant that the workers were potentially exposure to higher levels of PCDD/Fs emitted from secondary copper plant. The major congeners of Co-PCBs were PCB77, PCB169 and PCB126. The regression data showed serum PCDD/F/Co-PCBs were highly correlated with seniority and the exposure indices .The lifetime average daily does (LADD) of workers were met the range of WHO daily tolerance dose. The usage of personal protective measures was suggested to effectively reduce the exposure of PCDD/F/Co-PCBs.
SHU, Jing-Fang y 許菁芳. "The relationship between blood levels of PCB/PCDD/PCDF congeners and abnormal liver function in Yu-Cheng patients". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/10364812442109420204.
Texto completo國立成功大學
環境醫學研究所
88
Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzo-p-furans (PCDFs) are among the most widespread environmental pollutants. Accumulation in human tissues with these lipophilic compounds is often considered as a potential threat to human health. Livers are the most sensitive organs observed in toxicological animal studies and consequential liver damages caused by the toxins are commonly observed. Several epidemiological studies have shown that occupational and non-occupational human exposures of PCBs, PCDDs and PCDFs, such as those of PCBs in transformer/capacitor factories and PCDDs/PCDFs in an industrial accident occurring in Seveso, Italy, were linked to abnormalities in liver function. In these studies, levels of total PCBs/PCDDs/PCDFs, rather than levels of specific PCB/PCDD/PCDF congeners, in the blood samples are often used to study their association with the health effects. Abnormalities in liver function and liver cirrhosis were also reported in the Yu-cheng patients in Taiwan. A nested case-control design was used within a cohort of subjects, 2061 Yu-cheng patients in Taiwan, which has been followed up by Guo and his co-workers since 1991. The study aims to investigate the relationship between blood levels of PCB/PCDD/PCDF congeners and observed abnormal liver function in Yu-cheng patients by measuring the concentrations of specific congeners in the blood samples. Gas chromatography-electron capture detection (GC-ECD) and gas chromatography-high resolution mass spectrometry (GC-HRMS) are utilized for the congener-specific measurements. PCB/PCDD/PCDF congener levels in the blood of 41 Yu-cheng patients were analyzed. The average concentration of the total PCDDs/PCDFs of the blood samples was found to be 6893 pg/g-lipid and the concentration of 1,2,3,4,7,8-HxCDF (1741pg/g-lipid) was the highest among seventeen PCDD/PCDF congeners determined in the blood samples. The average total PCBs concentration in the blood samples was found to be 2921 pg/mg-lipid and the concentration of PCB 28/31 (397pg/mg-lipid) was the highest among thirty-four PCB congeners. After adjustment for cholesterol and body mass index (BMI), there were statistically significant positive correlations between liver function and some PCB levels (PCB 28/31, 44, and 189).