Literatura académica sobre el tema "Paired Helical Filaments"
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Artículos de revistas sobre el tema "Paired Helical Filaments"
Iqbal, K., I. Griindke-Iqbnl y H. M. Wisniewaki. "ALZHEIMER PAIRED HELICAL FILAMENTS". Journal of Neuropathology and Experimental Neurology 44, n.º 3 (mayo de 1985): 366. http://dx.doi.org/10.1097/00005072-198505000-00187.
Texto completoMetuzals, J. "Neurofilaments and Paired Helical Filaments". Proceedings, annual meeting, Electron Microscopy Society of America 43 (agosto de 1985): 740–43. http://dx.doi.org/10.1017/s0424820100120357.
Texto completoYoshida, Hirotaka y Yasuo Ihara. "? in Paired Helical Filaments Is Functionally Distinct from Fetal ?: Assembly Incompetence of Paired Helical Filament-?" Journal of Neurochemistry 61, n.º 3 (septiembre de 1993): 1183–86. http://dx.doi.org/10.1111/j.1471-4159.1993.tb03642.x.
Texto completoChen, Shu G. "Molecular profiling of paired helical filaments". Journal of Alzheimer's Disease 3, n.º 5 (30 de septiembre de 2001): 467–69. http://dx.doi.org/10.3233/jad-2001-3505.
Texto completoAnderton, Brian H. "Paired helical filaments and the cytoskeleton". Nature 335, n.º 6190 (octubre de 1988): 497–98. http://dx.doi.org/10.1038/335497a0.
Texto completoLhara, Yasuo y Jun Kondo. "Polypeptide Composition of Paired Helical Filaments". Annals of Medicine 21, n.º 2 (enero de 1989): 121–25. http://dx.doi.org/10.3109/07853898909149198.
Texto completoMori, H., J. Kondo, S. Kuzuhara y Y. Ihara. "UBIQUITIN IN ALZHEIMERʼS PAIRED HELICAL FILAMENTS". Journal of Neuropathology and Experimental Neurology 46, n.º 3 (mayo de 1987): 332. http://dx.doi.org/10.1097/00005072-198705000-00009.
Texto completoKidd, Michael. "The history of the paired helical filaments". Journal of Alzheimer's Disease 9, s3 (27 de julio de 2006): 71–75. http://dx.doi.org/10.3233/jad-2006-9s309.
Texto completoIhara, Yasuo. "Neurofibrillary tangles/paired helical filaments (1981–83)". Journal of Alzheimer's Disease 9, s3 (27 de julio de 2006): 209–17. http://dx.doi.org/10.3233/jad-2006-9s324.
Texto completoGRAY, E. G., M. PAULA-BARBOSA y A. ROHER. "ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANES". Neuropathology and Applied Neurobiology 13, n.º 2 (marzo de 1987): 91–110. http://dx.doi.org/10.1111/j.1365-2990.1987.tb00174.x.
Texto completoTesis sobre el tema "Paired Helical Filaments"
Wischik, Claude M. "The structure and biochemistry of paired helical filaments in Alzheimer's disease". Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315916.
Texto completoLi, Li. "Tryptophan and proline scanning mutagenesis a tool to study the aggregation of tau protein into Alzheimer paired helical filaments /". [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967241790.
Texto completoGuix, Ràfols Francesc Xavier. "Study of the pathophysiological role of nitric oxide on the amyloid-induced toxicity attending to the biochemical modifications and cellular damages". Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7162.
Texto completoPer altra banda, des de la identificació dels agregats d'A i la subseqüent formació dels cabdells neurofibrilars (NFT) com a els dos trets distintius de la malaltia, un gran esforç s'ha dedicat a establir els mecanismes moleculars que uneixen ambdós processos. Aquesta tesi demostra que el peroxinitrit format a partir de l'agregació de d'Ai la conseqüent nitrotirosinació de proteïnes, potencia l'agregació de la proteïna tau en forma de fibres. D'aquesta forma, la nitrotirosinació de la proteïna triosafosfat isomerasa (TPI) podria ser el vincle entre la toxicitat derivada del agregats d'Ai la patologia derivada de la proteïna tau. Per tant, la nitrotirosinació de la TPI podria explicar la progressió temporal que ocorre als cervells de pacients amb la malaltia d'Alzheimer des de la toxicitat induïda per l'Ai l'aparició dels NFT. Els resultats presentats en aquesta tesi podrien obrir nous aspectes en la recerca de la malaltia d'Alzheimer així com en altres malalties que cursin amb estrès oxidatiu i plegament erroni de proteïnes.
This thesis demonstrates that amyloid ß-peptide (Aß)-induced peroxynitrite contributes to the switch of the Aβ42/Aβ40 ratio that occurs in Alzheimer's disease (AD). Since Aβ42 is more toxic due to its higher aggregation and stability, it contributes to the trigger of the disease. In addition the aggregation of Aβ42 in form of the highly toxic oligomers is incremented by the presence of peroxynitrite. Moreover, these nitro-Aß42 oligomers are more toxic than those non-nitrated. All these results support the important role of peroxynitrite in AD etiology.
Furthermore, since the identification of Aß accumulation and the subsequent formation of neurofibrillary tangles (NFT) as the two defining pathological hallmarks of AD, a fair amount of research on AD has been driven by the need to find the molecular mechanism linking Aß and NFT. This thesis shows the Aß-induced peroxynitrite, and the consequent nitrotyrosination of proteins, promotes tau fibrillization. Thus triosephosphate isomerase (TPI) nitrotyrosination could be the link between Aß-induced toxicity and tau pathology. Therefore, TPI nitrotyrosination may explain the temporal progression from Aß toxicity to NFT formation in AD brain. The work presented in this thesis could open a novel angle in the research of the pathophysiology of AD and could also have an impact to the research in other neurodegenerative diseases involving oxidative stress and protein misfolding.
Li, Li [Verfasser]. "Tryptophan and proline scanning mutagenesis : a tool to study the aggregation of tau protein into Alzheimer paired helical filaments / presented by Li Li". 2003. http://d-nb.info/967241790/34.
Texto completoCapítulos de libros sobre el tema "Paired Helical Filaments"
Wisniewski, H. M. y K. Iqbal. "Paired Helical Filaments (PHF): Update 1988". En Genetics and Alzheimer’s Disease, 157–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73647-6_17.
Texto completoMandelkow, E., M. von Bergen, A. Marx, J. Biernat y E. M. Mandelkow. "The Search for structure of tau and paired helical filaments". En Alzheimer: 100 Years and Beyond, 355–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-37652-1_45.
Texto completoMandelkow, E., J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke, K. Baumann y E. M. Mandelkow. "Microtubules, Tau Protein,and Paired Helical Filaments in Alzheimer’s Disease". En The Cytoskeleton, 143–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79482-7_16.
Texto completoDelacourte, A. y A. Defossez. "Paired Helical Filaments in Alzheimer’s Disease: Their Formation and Transformation". En Immunology and Alzheimer’s Disease, 55–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-46634-2_6.
Texto completoMandelkow, E. M., J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke, K. Baumann y E. Mandelkow. "Phosphorylation of Tau and Its Relationship with Alzheimer Paired Helical Filaments". En Alzheimer’s Disease: Lessons from Cell Biology, 103–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79423-0_10.
Texto completoMandelkow, Eckhard, Peter Friedhoff, Jacek Biernat y Eva-Maria Mandelkow. "The Conformations of Tau Protein and its Aggregation into Alzheimer Paired Helical Filaments". En Advances in Behavioral Biology, 223–33. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5337-3_32.
Texto completoOtvos, Laszlo, Virginia M. Y. Lee, Susan Leight, Peter Davies y Ralf Hoffmann. "Multiphosphorylated synthetic peptides as antigens and immunogens in Alzheimer’s disease paired helical filaments". En Peptides Frontiers of Peptide Science, 695–97. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/0-306-46862-x_304.
Texto completoSelkoe, Dennis J., Carmela Abraham y C. G. Rasool. "Molecular Properties of Paired Helical Filaments and Senile Plaque Amyloid Fibers in Alzheimer’s Disease". En Advances in Behavioral Biology, 37–42. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2179-8_5.
Texto completoLee, Virginia M. Y. y Laszlo Otvos. "Identification of an abnormal phosphorylation site in Alzheimer’s disease paired helical filaments using synthetic peptides". En Peptides, 109–12. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_34.
Texto completoSelkoe, Dennis J. y Carmela Abraham. "Biochemical and Structural Studies of Paired Helical Filaments and Senile Plaque Amyloid in Alzheimer’s Disease". En Amyloidosis, 709–15. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2199-6_90.
Texto completoActas de conferencias sobre el tema "Paired Helical Filaments"
Stork, Larissa Rosa, Lucca Stephani Ribeiro, Izabella Savergnini Deprá, Luísa D’Ávila Camargo y Maria Angélica Santos Novaes. "Tau protein and its role in Alzheimer’s disease physiopathology: a literature review". En XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.132.
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