Tesis sobre el tema "P2D"
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Perez, Paulo Andre Sant\'Anna. "P2D - Um Ambiente de Auxílio a Paralelização de Aplicações Fortran". Universidade de São Paulo, 1996. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-15012018-095545/.
Texto completoThis thesis presents an integrated environment to help with the parallelization of serial Fortran applications. This is an effort to provide improved tools for parallel programming, a need emphasized by the review of the bibliography presented. Software Engineering principles are extensively used in this work. The system definition is based on a deep analysis of its goals, requirements and applications. The software project and the algorithms used for parallel code generation are discussed. Some results obtained from case studies are presented and analysed. Finally, several new research projects are proposed aiming at the continuity of this work.
Bandla, Venkat Nehru. "Modeling the internal inhomogeneous aging behavior in large-format commercial Li-ion batteries". Thesis, Amiens, 2018. http://www.theses.fr/2018AMIE0027/document.
Texto completoLi-ion batteries (LIB) are used as energy storage devices in automobile, mobile and stationary applications. However their lifetime issue is a primary concern resulting in a decreased performance. Li-ion batteries exhibit non-uniform behavior that results in incomplete utilization of the cell energy and non-uniform aging. Thus the objective of this work is to identify the factors influencing the inhomogeneous behavior and to study their effect on aging. A combined modeling and experimental approach is adopted in this work. In the experimental work, a setup is developed that surrogates the thermal and potential gradients occurring in commercial LIB. This setup is used to perform long-term accelerated cycling tests and inhomogeneous aging behavior is assessed. Several characterization tests are performed during and after the completion of the cycling. In the modeling part, multiphysics models describing the electrochemical, electrical and thermal behavior of LIB are developed. These models are appropriately coupled integrated with an aging component to represent the experimental setup behavior. Two main degradation phenomena, namely SEI (Solid Electrolyte Interface) formation and positive electrode active material have been identified experimentally and modelled. The latter is uniform whereas the former is influenced by temperature. Based on this, thermal dispersion impact on the inhomogeneity is greater than potential dispersion
Jokar, Ali. "An inverse method for estimating the electrochemical and the thermophysical parameters of lithium-ion batteries with different positive electrode materials". Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11799.
Texto completoAbstract : The safety of many electrical systems is strongly dependent on the reliable operation of their lithium-ion (Li-ion) battery packs. As a result, the battery packs must be monitored by a battery management system (BMS). The BMS interacts with all the components of the system so as to maintain the integrity of the batteries. The main part of a BMS is a Li-ion battery model that simulates and predicts its different operating points. In the electronics and in the automobile industries, the BMS usually rests on simple empirical models. They are however unable to predict the battery parameters as it ages. Furthermore, they are only applicable to a specific cell. Electrochemical-based models are, on the other hand, more sophisticated and more precise. These models are based on chemical/electrochemical kinetics and transport equations. They may be used to simulate the Li-ion battery characteristics and reactions. In order to run the electrochemical-based mathematical models, it is imperative to know the different electrochemical and thermophysical parameters of the battery. The significant variables of the Li-ion battery can be classified into three groups: geometric, material and operational parameters. The geometric and material parameters can be easily obtained from direct measurements or from the datasheets provided by the manufacturer. The operational properties are, on the other hand, not easily available. Furthermore, some of them may vary according to the measurement techniques or the battery age. Sometimes, the measurement of these parameters requires the dismantling of the battery itself, which is a risky and destructive procedure. Many investigations have been conducted to identify the operational parameters of Li-ion batteries. However, most of these studies focused on the estimation of limited parameters, or considered only one type of the positive electrode materials used in Li-ion batteries. Moreover, the coupling of the thermophysical parameters to the electrochemical variables is ignored in all of them. The main goal of this thesis is to develop a general method to simultaneously identify different electrochemical and thermophysical parameters and to predict the performance of Li-ion batteries with different positive electrode materials. To achieve this goal, an effective inverse method is introduced. Also, direct models representative of Li-ion batteries are developed, applicable for all of the positive electrode materials. A fast and accurate model is presented for simulating the performance of the Li-ion batteries with the LiMn2O4 and LiCoO2 positive electrodes. Moreover, two macro- and micro-based models are developed for predicting the performance of Li-ion battery with the LiFePO4 positive electrode, namely the Modified Mosaic (MM) and the mesoscopic-based models. The parameter estimation studies are then implemented by means of the developed direct models and experimental data provided by Hydro-Québec. All electrochemical and thermophysical parameters of the Li-ion batteries are simultaneously identified and applied for the prediction of the battery performance. Finally, a real-time technique resting on neural networks is used for the estimation of the Li-ion batteries intrinsic parameters.
Domingo, Prieto Marc. "Integrating secure mobile P2P systems and Wireless Sensor Networks". Doctoral thesis, Universitat Oberta de Catalunya, 2017. http://hdl.handle.net/10803/404534.
Texto completoEsta tesis trata las diferentes limitaciones encontradas en WSN para habilitar su despliegue en nuevos escenarios, así como facilitar la diseminación de la información obtenida. A bajo nivel, nos centramos en el consumo de energía, mientras que, a un nivel más alto, nos focalizamos en la diseminación y seguridad de la información. Reducimos el consumo de una mota individual en redes con patrones de tráfico dinámico mediante la definición de una función de planificación basada en el conocido controlador PID y alargamos la vida de una WSN globalmente distribuyendo equitativamente el consumo energético de todas las motas, disminuyendo el número de intervenciones requeridas para cambiar baterías y su coste asociado. Para favorecer la diseminación de la información procedente de una WSN hemos propuesto jxSensor, una capa de integración entre las WSN y el conocido sistema P2P JXTA. Como estamos tratando con información sensible, hemos propuesto una capa de anonimato en JXTA y un mecanismo de autenticación ligero para su versión móvil.
This thesis addresses different limitations found in WSNs in order to enable their deployment in new scenarios as well as to make it easier to disseminate the gathered information. At a lower level, we concentrate on energy consumption while, at a higher level, we focus on the dissemination and security of information. The consumption of an individual mote in networks with dynamic traffic patterns is reduced by defining a scheduling function based on the well-known PID controller. Additionally, the life of a WSN is extended by equally distributing the consumption of all the motes, which reduces the number of interventions required to replace batteries as well as the associated cost. To help the dissemination of information coming from a WSN we have proposed jxSensor, which is an integration layer between WSNs and the well-known JXTA P2P system. As we are dealing with sensitive information, we have proposed an anonymity layer in JXTA and a light authentication method in its mobile version.
Glentis, S. "Whole genome amplification for PGD and PND : molecular and a-CGH diagnosis". Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18554/.
Texto completoXavier, Carlos Roberto. "Simulação numérica da soldabilidade dos aços ferríticos T/P23 e T/P24". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/18289.
Texto completoThe aim of this work is to evaluate qualitatively the metallurgical transformations during the welding of the low alloy ferritic steels T/P23 e T/P24 when welded with different welding energy, preheat temperatures and base metal thickness. It was used a model based at heat transfer equation that apply the finite volume numerical method and implemented in a computational code in FORTRAN programming language. It was aimed at this work the numerical simulation of the effects of the energy change, base metal thickness and preheating temperature on the cooling curve during continuous cooling transformation of these steels. It was simulated a situation where a single weld fillet was deposited on plates of the investigated steels by the GMAW process. A heat source model based on Goldak`s double-ellipsoid power density distribution was utilized in order to get a good approximation of the weld penetration and cooling rate. The results obtained had a good qualitative agreement with the literature.
Pineda, Van L. "Regulation of the human asparagine synthetase, p21, and p27 genes by amino acid deprivation". [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001259.
Texto completoSaleh, Marwan. "Étude mathématique et numérique des méthodes de réduction dimensionnelle de type POD et PGD". Thesis, La Rochelle, 2015. http://www.theses.fr/2015LAROS004/document.
Texto completoThis thesis is formed of four chapters. The first one presents the mathematical notions and tools used in this thesis and gives a description of the main results obtained within. The second chapter presents our generalization of a result obtained by Rousselet-Chenais in 1990 which describes the sensitivity of eigensubspaces for self-adjoint compact operators. Rousselet-Chenais were limited to sensitivity for specific subspaces of dimension 1, we have extended their result to higher dimensions. We applied our results to the Proper Orthogonal Decomposition (POD) in the case of parametric, temporal and spatial variations (Gappy- POD). The third chapter discusses the optical flow estimate with quadratic or linear energies at infinity. Mathematical results of convergence are shown for the method Progressive Generalized Decomposition (PGD) in the case of quadratic energies. Our proof is based on the decomposition of Brézis-lieb via the convergence almost everywhere of the PGD sequence gradients. A detailed numerical study is made on different types of images : on the passive scalar transport equations, whose displacement fields are solutions of the Navier-Stokes equations. These equations present a challenge for optical flow estimates because of the presence of low gradient regions in the image. We applied our method to the MRI image sequences to estimate the movement of the abdominal organs. PGD presented a superiority in both computing time level (even in 2D) and accuracy representation of the estimated motion. The local diffusion of standard methods (Horn Schunck, for example) limits the convergence rate, in contrast to the PGD which is a more global approach by construction. The last chapter deals with the application of PGD method in the case of variational elliptic equations whose energy present all challenges to classical variational methods : lack of convexity, lack of coercivity and lack of boundedness. We prove convergence results for the weak topology, the PGD sequences converge (when they are well defined) to two extremal solutions on the Nehari manifold. Several mathematical questions about PGD remain open in this chapter. These questions are part of our research perspectives
Kong, Qiongman. "Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system". Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4847.
Texto completoThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 19, 2009) Vita. Includes bibliographical references.
Lossaint, Gérald. "Mécanismes orchestrant la sortie du cycle cellulaire opérant en G2". Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20040/document.
Texto completoCancer is a multi-step process resulting from abrogation of several barriers to uncontrolled proliferation. They include inhibitory pathways with appropriate checkpoints that lead to reversible (quiescence) or irreversible (senescence, apoptosis) block of cell proliferation. We are especially interested in pathways orchestrating cell cycle exit that operate in the G2 phase. The first objective of this thesis was to decipher mechanisms that prevent mitosis in response to DNA damage. We found that Cdk inhibitor p21Waf1 plays a crucial role in blocking mitotic onset in normal cells; acting in tandem with checkpoint kinase Chk1, p21 inactivates mitotic Cdks and inhibits pRb phosphorylation, thereby irreversibly blocking mitotic entry. In contrast, in p53-proficient transformed cells, the induction of p21 in G2 is impaired, most likely because of deficient ATM activation. While, in some cases, Chk1 hyper-activation prevents mitosis, the absence of p21 compromises the senescence program from G2. Finally, we showed that Chk2 is dispensable for G2 arrest in both non-transformed and transformed cells (Lossaint et al., submitted). Our second objective was to elucidate the pathways that induce quiescence (G0). This reversible cell cycle exit occurs in G1, requires pRb family members and p27Kip1-dependent Cdk inactivation. Based on observations obtained in our team and the data in the literature, we hypothesized that reversible cell cycle exit program might be launched before mitosis. By using an in vitro wounding model, we showed that confluence-driven quiescence is preceded by pre-mitotic CDK inhibition by p27, cyclin D1 downregulation and reduced pre-mitotic pRb phosphorylation (Chassot et al., 2008). Moreover, our results obtained in synchronized fibroblasts that were serum-starved after release from G1/S block suggest that cyclin D1 might stimulate proliferation by keeping pocket proteins phosphorylated during G2/M progression (Lossaint et al., in preparation)
Vick, Jonathan. "The Contribution of Purinergic P2X and P2Y Receptors to the Excitability of Mouse Vomeronasal Sensory Neurons". ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/283.
Texto completoEllis, Cameron B. "Tribopairs in Wellbore Drilling: A Study of PCD Tilting Pad Bearings in an Electric Submersible Pump". BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7233.
Texto completoPerez, Madrigal Diana. "The role of ERK5 in cell proliferation". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-erk5-in-cell-proliferation(ee569cda-581d-4698-80c0-84f15fe88f53).html.
Texto completoDavies, Susan Jeanette. "Identification of genes involved in craniofacial development and disrupted in a patient with t(6;9)(p24 p23)". Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408916.
Texto completoZgrebňák, Michal. "Využití systému Raspberry PI pro řízení". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2018. http://www.nusl.cz/ntk/nusl-377000.
Texto completoVilardell, Villellas Felip. "Avaluació de la utilitat com a marcadors pronòstics en càncer colorectal de P53, P21, P27 i ciclina E". Doctoral thesis, Universitat de Barcelona, 2005. http://hdl.handle.net/10803/868.
Texto completoHIPÒTESI: L'estudi d'algunes proteïnes reguladores del cicle cel.lular en càncer colorectal, ha d'aportar informació pronòstica complementària a l'estadi de Dukes.
OBJECTIUS: Identificació de perfils fenotípics en l'adenocarcinoma colorectal que puguin aportar informació pronòstica suplementària a l'estudi anàtomo-patològic habitual, mitjançant l'anàlisi integrat de mutacions de p53, del polimorfisme AA 72 Arg/Pro de p53, i d'expressió de p53, p21, p27 i ciclina E.
MATERIAL I MÈTODES: Sèrie consecutiva de 185 adenocarcinomes colorectals ressecats electivament. Anàlisi mutacional del exons 5-8 de p53 mitjançant PCR-SSCP i seqüenciació, i del polimorfisme Arg/Pro 72 de p53 mitjançant PCR- SSCP. Anàlisi mitjançant immunohistoquímica (IHQ) sobre seccions parafinades, de sobreexpressió de p53 i d'expressió de p21, p27 i ciclina E. Repetició de la IHQ de p21 i p27 en un array tissular.RESULTATS. Major freqüència de mutacions de p53 en els tumors GG (arg72) que en els CC (pro72) o GC. Les mutacions de p53 localitzades en L3 i LSH es van associar a pitjor supervivència global(p = 0.04; ajustada per Dukes < 0.01). La sobreexpressió IHQ de p53 va correlacionar amb l'estadi de Dukes, però no amb supervivència. Els tumors amb mutacions de p53 inhibidores de p73 van mostrar en l'anàlisi multivariant una pitjor supervivència global que els tumors amb altres mutacions (p= 0.04). En el grup de tumors GG, els carcinomes amb aquestes mutacions van tendir a una pitjor supervivència global (p= 0.08). Dins del grup de tumors GG, aquells amb mutació en L3 i LSH van mostrar al ajustar per Dukes, pitjor supervivència global que els tumors amb p53 salvatge o amb altres mutacions (p= 0.005). Aquesta correlació no es va observar dins el grup GC-CC.
L'expressió IHQ de p21 es va associar a millor supervivència. També es va associar a millor supervivència lliure de malaltia en el grup de pacients que havien rebut tractament amb quimioteràpia. Els carcinomes amb mutació hot spot en L3 i LSH de p53 i pèrdua d'expressió p21 van mostrar pitjor supervivència global, fins i tot ajustant per Dukes. L'expressió de p27 va correlacionar amb millor supervivència global però de manera dependent a l'estadi de Dukes.
Els carcinomes amb alt percentatge d'expressió de ciclina E van mostrar inesperadament, millor supervivència global. A més, els carcinomes amb expressió dèbil de ciclina E en més d'un 12% de nuclis van mostrar millor supervivència que aquells amb expressió nul.la o molt intensa d'aquesta proteïna.
Finalment, en una sèrie de 146 adenocarcinomes curativament ressecats, l'anàlisi dels codons 245, 248, 273 i 282 de p53, i l'anàlisi IHQ de p21, es van mostrar com uns bons marcadors de supervivència global.
CONCLUSIONS: En càncer colorectal, l'anàlisi dels codons 245, 248, 273 i 282 de p53, aporta informació pronòstica sobre supervivència global independent de l'estadi de Dukes.L'estudi de p21 mitjançant IHQ en carcinomes colorectals completament ressecats, és un mètode d'anàlisi senzill i econòmic, amb valor pronòstic independent de l'estadi de Dukes, i podria ser utilitzat en la pràctica assistencial.
ASSESSMENT OF THE VALUE AS PROGNOSTIC MARKERS IN COLORECTAL CANCER OF P53, P21, P27 AND CYCLIN E.
ABSTRACT
INTRODUCTION: The value as prognostic markers in colorectal cancer of p53, p21, p27 and cyclin E still remains controversial.
HIPOTHESIS: The study of some proteins that regulate the cell cycle should give prognostic information, complementary to the Dukes' stage.
AIMS: To identify phenotypical profiles in the colorectal adenocarcinoma which could give prognostic information complementary to the usual pathological study, by means of an integral analysis of p53, with assessment of mutations, protein overexpression and the AA 72 Arg/Pro polymorphism of p53, and expression analysis of p21, p27 and cyclin E.
MATERIAL AND METHODS: A consecutive series of 185 colorectal cancers electively extirpated. Mutational analysis of the exons 5-8 of p53 by means of PCR-SSCP and sequencing and of the 72 Arg/Pro polymorphism by PCR-SSCP. Expression analysis by means of immunohistochemistry (IHC) on whole paraffin sections of p53, p21, p27 and cyclin E. Repetition of the IHC analysis of p21 and p27 on tissue-array sections.
RESULTS: It was observed a greater frequency of p53 mutations in GG tumours (Arg 72) than in CC or GC tumours. The mutations of p53 located at the L3 loop and the LS -helix motif was associated to a clear worse overall survival (p<0.01 adjusted by Dukes).
P53 overexpression assessed by means of IHC correlated with Dukes'stage but not with survival.
The tumours with mutations of p53 which inhibit p73 showed, at the multivariant analysis, a worse overall survival than the tumours with other p53 mutations (p= 0.04). Among the GG tumours, those with these mutations of p53 tended to a worse overall survival (p= 0.08). Also, in the group of GG tumours, those with p53 mutations at L3 and LSH showed, adjusting by Dukes, a worse overall survival than the tumours with other p53 mutations or wild type protein.P27 expression correlated with a better overall survival but in a depending mode with the Dukes'stage.
Finally, in a series of 146 curatively extirpated tumours, the analysis of the codons 245, 248, 273 and 282, and the analysis of p21 expression by means of IHC showed to be good prognostic markers for overall survival.
CONCLUSIONS: In colorectal cancer, the study of the codons 245, 248, 273 and 282 of p53, and the analysis of p21 expression, give prognostic information about overall survival independently of the Dukes'stage.
Stock, Maria José de Souza Dias Fernández. "Elites, facções e conflito intra-partidário: o PPD/PSD e o processo político portugês de 1974 a 1985". Doctoral thesis, Universidade de Évora, 1989. http://hdl.handle.net/10174/12351.
Texto completoBollu, Lakshmi Reddy. "The Effect of Endothelin-1 on the expression of CDK Inhibitors p21 & p27 in Bovine Corneal Endothelial Cells". TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/112.
Texto completoWißner, Thomas Friedrich [Verfasser] y G. [Akademischer Betreuer] Richter. "Bewertung der Präimplantationsdiagnostik (PID) und Pränataldiagnostik (PND) durch Humangenetiker und Reproduktionsmediziner, Gynäkologen in Deutschland / Thomas Wißner. Betreuer: G. Richter". Marburg : Philipps-Universität Marburg, 2012. http://d-nb.info/1021498920/34.
Texto completoTadi, Bhaskar Vijay Kumar Reddy. "Ultrasound hardware setup for CMP pad characterization". [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000340.
Texto completoStövesand, Kirsten [Verfasser]. "Untersuchungen des Expressionsprofils der Cyclin-abhängigen Cyclinkinase-Inhibitoren p21 CIP1/WAF1 und p27 KIP1 in spontanen Mammatumoren beim Hund / Kirsten Stövesand". Berlin : Freie Universität Berlin, 2008. http://d-nb.info/1022707167/34.
Texto completoL'Ériger, Karine. "Régulation transcriptionnelle du récepteur P2X[indice inférieur 7] et son rôle dans le trafic membranaire du transporteur à glucose Glut2 dans les cellules épithéliales intestinales". Mémoire, Université de Sherbrooke, 2009. http://savoirs.usherbrooke.ca/handle/11143/4034.
Texto completoChen, Xiaowei. "Involvement of purinergic P2X and P2Y2 receptors in urinary bladder sensation". Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/343.
Texto completoMateos-Trigos, Gabriela. "P2 receptors (P2Y₁ and P2Y₁₂) of equine platelets". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620715.
Texto completoLorraine, Ross James. "PhD - Composition". Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398867.
Texto completoRighi, Rafael da Rosa. "P2P-role". Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/102583.
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Os sistemas Peer-to-Peer apresentam uma forma de computação distribuída onde cada participante atua como cliente e servidor de recursos. Entre os principais desafios existentes nesse tipo de computação, estão o desenvolvimento de técnicas para incentivar a colaboração entre os usuários e a proteção dos elementos e informações localizados no ambiente Peer-to-Peer. Este documento define uma arquitetura de controle de acesso baseada em papes específica para as redes Peer-to-Peer e busca, assim, contribuir para a construção de sistemas colaborativos mais robustos e seguros. Também são exploradas as relações entre o controle de acesso e as técnicas utilizadas para estimular a cooperação entre os integrantes da rede Peer-to-Peer. Pretende-se, dessa forma, que a arquitetura de controle de acesso definida também auxilie para minimizar a quantidade de nós que não colaboram com rede e que apenas sugam seus recursos. O protótipo implementado baseia-se nas tecnologias JXTA e P2PSockets e provê meios para que cada nó da rede P2P gerencia a política de segurança de seus recursos.
López, Lorenzo Ximena. "Mapping the Expression of Cyclin Dependent Kinase Inhibitors in High-Risk Neuroblastoma Cell Lines : Dynamics on Cell-Fate Decisions on Proliferation/Cell Cycle Arrest". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278705.
Texto completoDålig prognos för högrisk neuroblastompatienter gör det nödvändigt att hitta nya behandlingsstrategier.Detta arbete syftar till att förstå cellcykelbeteendet hos olika högrisk neuroblastomcellinjerefter kemoterapibehandling. I denna studie kartlades uttrycket av cellcykelberoendeproteinerna, p21 och p27, i sju högrisk neuroblastomcellinjer. Alla cellinjervisade en total nedsatt tillväxt efter doxorubicinbehandling. Återväxt observerades emellertidmellan dag 6 och 15 genom bildandet av kolonier. Uttrycket av p21 och p27 mättesi alla cellinjer. Resultaten visade en uppreglering av p21 i 3 av 5 p53-muterade cellinjermedans det nedreglerades i de två cellinjerna med en p53-vildtyp. Vidare utfördes inhiberingsanalysermed användning av hämmare mot CHK1/2, p21 eller, SKP2. Resultatenär lovande då CHK1/2-hämmaren reducerade cellviabiliteten i alla testade cellinjer, medanp21-hämmaren hade en effekt i 3 av 6 testade cellinjer och SKP2 i 4 av 6 testadecellinjer. Konfluensmätning under 15 dagar visade nedsatt tillväxt efter behandling medCHK1/2-hämmaren för 3 av 6 testade cellinjer och p21-hämmare i 1 av 6 testade cellinjer.De erhållna resultaten är lovande och kan hjälpa till att hitta en ny behandlingsstrategi somförhindrar resistens och återfall i neuroblastom. Ytterligare studier behövs emellertid föratt validera effektiviteten och säkerheten för dessa lovande läkemedel hos neuroblastompatienter.
Lima, Caroline Rocha de Oliveira. "Classificação morfológico, critérios de malignidade, expressão gênica de C-MYC e imunoistoquímica de C-MYC, p53, p21 e p27 no tumor venéreo transmissível canino". Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3258.
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The present concept about carcinogenesis is that normal cells are transformed into tumor by mutations that activate oncogenes, inhibit tumor suppressor genes or trigger genetic instability. However, studies suggest that some neoplastic types can behave like infectious agents and be transmitted from one host to another, similar to what occurs with the canine transmissible venereal tumor (TVT). The TVT histogenesis is not fully known, because the studies are controversial and do not bring about the results elucidating cell line that characterized the neoplasm. However, research continues in order to elucidate this question and identify the ancestral genetic TVT. Recently, a cytomorphological classification was proposed for the TVT, including plasmacytoid types, linfocitoide and mixed. Nevertheless, many features of the development and behavior of this dogs transmissible neoplasm are still poorly understood. Accordingly, we evaluated the different morphological patterns of the tumor, the macroscopic aspects, the criteria of malignancy, the molecular identification of the tumor, by inserting the element LINE-1 in the C-MYC gene, the immunohistochemical expression of the C-MYC, p53, p21 and p27, and the relationship between the proteins C-MYC, p53, p21 and p27, the block of the cell cycle and apoptosis of tumor cells. The results indicate that the cytological examination allows better characterization of patterns and cytomorphologic criteria of malignancy of TVT compared to histological examination, which can identify the types plasmacytoid, linfocitoide and mixed. It was further observed that the TVT presents morphological peculiarities that may interfere with tumor behavior and response to chemotherapy, especially those related to more aggressive and have been observed in plasmacytoid TVT, cytomorphological most common type of this tumor. The identification of molecular rearrangement LINE-1/C-MYC features specific molecular changes for TVT that may be introduced as supplementary diagnostic method of cancer, especially in highly undifferentiated tumors. Immunohistochemical analysis and the relationship between C-MYC, p53, p21 and p27 revealed functional abnormalities in these proteins, interfering with biological events in cell cycle control and apoptosis, and may thus contribute to the genesis and neoplastic progression.
O conceito atual sobre carcinogênese refere que células normais se transformam em tumorais por mutações que modificam proto-oncogenes transformando-os em oncogenes, inibem genes supressores tumorais ou que disparam instabilidades genéticas. No entanto, estudos sugerem que alguns tipos neoplásicos podem se comportar como agentes infecciosos e ser transmitidos de um hospedeiro a outro, a exemplo do que ocorre com o tumor venéreo transmissível canino (TVT). A histogênese do TVT não é totalmente conhecida, pois os estudos são controversos e não trazem resultados elucidativos quanto à linhagem celular que caracterizou a neoplasia. Entretanto, as pesquisas continuam com o objetivo de elucidar essa questão e identificar o ancestral genético do TVT. Recentemente, uma classificação citomorfológica foi proposta para o TVT, incluindo os tipos plasmocitoide, linfocitoide e misto. Apesar disso, muitas características de desenvolvimento e comportamento dessa neoplasia transmissível dos cães ainda são pouco entendidas. Nesse sentido, foram avaliados os diferentes padrões morfológicos do tumor, os aspectos macroscópicos, os critérios de malignidade, a identificação molecular da neoplasia, por meio da inserção do elemento LINE-1 no gene C-MYC, a expressão imunoistoquímica das proteínas C-MYC, p53, p21 e p27, e a relação entre as proteínas C-MYC, p53, p21 e p27, o bloqueio do ciclo celular e a apoptose das células tumorais. Os resultados indicam que o exame citopatológico permite melhor caracterização dos padrões citomorfológicos e critérios de malignidade do TVT em relação ao exame histopatológico, sendo possível identificar os tipos plasmocitoide, linfocitoide e misto. Constatou-se ainda que o TVT apresenta particularidades morfológicas que podem interferir no comportamento tumoral e na resposta à quimioterapia, especialmente aquelas relacionadas à maior agressividade e que foram observadas no TVT plasmocitoide, tipo citomorfológico mais comum da neoplasia. A identificação do rearranjo molecular LINE1/C-MYC caracteriza alteração molecular específica do TVT e pode ser utilizada como método diagnóstico complementar da neoplasia, principalmente em tumores indiferenciados. A análise imunoistoquímica e a relação entre C-MYC, p53, p21 e p27 indicam anormalidades funcionais nessas proteínas, interferindo nos eventos biológicos de controle do ciclo celular e da apoptose, podendo, dessa forma, contribuir nos processos de crescimento e progressão do TVT.
Rossi, Manuel. "Progettazione e messa in servizio di un impianto sperimentale per il Power to Hydrogen". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Buscar texto completoJones, Sarah Anne Louise. "Differential expressions of cell cycle regulatory proteins and ERK1-2 characterize the proliferative smooth muscle cell phenotype induced by allylamine". Diss., Texas A&M University, 2003. http://hdl.handle.net/1969/124.
Texto completoMurray, Nicholas Durante. "Nonlinear PID controller". Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03242009-040653/.
Texto completoBoardman, Gregory. "Musical composition : PhD". Thesis, Keele University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269183.
Texto completoTaip, Farah Saleena. "Revisiting PID control". Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430928.
Texto completoFretwell, Paul. "PhD in composition". Thesis, City University London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270604.
Texto completoRiddell, Richard Rodford. "PhD by publication". Thesis, Bath Spa University, 2012. http://researchspace.bathspa.ac.uk/1578/.
Texto completoBordon, Mario Eduardo. "Controlador PID microprocessado". [s.n.], 1993. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261561.
Texto completoDissertação (mestrado) - Universidade Estadual de Campinas, FAculdade de Engenharia Eletrica
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Resumo: o uso de controladores digitais tem se tornado cada vez mais abrangente em se tratando de controle de processos industriais. Neste trabalho apresenta-se um controlador PID digital simples, robusto, eficiente e que procura atender à faixa de controladores de uso geral. A partir dos estudos realizados chegou-se a um controlador baseado na arquitetura do microcontrolador 8051, com alto desempenho e processamento simplificado, comprovados através de testes práticos e simulados, utilizando- se simuladores analógicos e digitais de processos eletrônicos, envolvendo baixa e média potência. Uma das principais vantagens observadas neste controlador, é o tamanho reduzido do algorítmo de controle, conferindo ao mesmo características próprias, tais como: tempo de amostragem mínimo de 150 ~s e controle de processos com tempo de resposta igualou superior a 10 ms. o deslocamento automático da faixa de ajuste dos pa~âmetros do controlador em função do tempo de amostragem, é outra característica importante que dá a este controlador a flexibilidade necessária ao controle de processos industriais e de manufatura
Abstract: The use of digital controllers have become embraced when concerning about industrial processes controlo This work presents a simple, robust and efficient PID digital controller that looks for attending a general purpose controllers range. This controller is based on the 8051 micro controllers family's. Practical and simulated tests performed with analog and digital process simulators of low and medium power electronic systems, verify its high performance and simplified processing. One of main advantages observed in this controller is the algorithm small size, which has particular characteristics such as: minimum sampling time of 150 J1S and capability of controlling processes with response time of 10 ms, or higher. Another important feature is the automatic shifting of controller parameters adjusting range, which gives to this controller the necessary flexibility to industrial processes and manufacturing controlo
Mestrado
Mestre em Engenharia Elétrica
Melo, Raquel Alexandra Abrantes. "P2P service exposer". Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/7811.
Texto completoSmart homes were developed to improve inhabitants comfort by integrating electronic devices that perform the control of domestic activities, such as home entertainment systems, yard watering, house cleaning, etc. They are equipped with sensors and actuators that rely on P2P networking to share services and resources amongst them. To perform home management, inhabitants want to access their homes, from anywhere in the world using everyday devices, like smartphones. These devices aren’t peers of the network. They are outsiders that use a technology different, accessing the in-house P2P networks through Service Exposers, a special set of peers that expose the services available in the P2P network. Expose the services is challenging, because services in the network are always changing, new services can appear and the existing can change their locations and methods. These peers use a different technology; non-standard and inaccessible by devices like smartphones. For this, a P2P Service Exposer architecture is proposed, that indexes all the services available in the network, expose them to clients in a standardized platform, such as Web Services, and perform translations between the two different technological environments.
Březina, Matej. "Detekce P2P sítí". Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2008. http://www.nusl.cz/ntk/nusl-236012.
Texto completoČerná, Tereza. "Město pod hvězdami". Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2019. http://www.nusl.cz/ntk/nusl-401806.
Texto completoBednall, David Neil. "PhD in Composition". Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684646.
Texto completoKalodikis, Georgia. "PhD in composition". Thesis, Goldsmiths College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539853.
Texto completoNovák, Tomáš. "Penzion Pod Hradem". Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-410067.
Texto completoPelikán, Leoš. "Průmyslový PSD regulátor". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219666.
Texto completoJones, Clare Alexa. "Molecular pharmacology of P2X{sub4} and P2X{sub6} receptors for ATP". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620195.
Texto completoMemon, Ghulam. "On P2P Networks and P2P-Based Content Discovery on the Internet". Thesis, University of Oregon, 2014. http://hdl.handle.net/1794/17907.
Texto completoPalazzi, Emanuele. "Analisi sperimentale e progettazione di cinematismi atti alla movimentazione di devices protesici all’interno di una camera di deposizione pvd". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11563/.
Texto completoChatzidrossos, Ilias. "P2P Live Video Streaming". Licentiate thesis, KTH, Communication Networks, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12373.
Texto completoThe ever increasing demand for video content directed the focus of researchfrom traditional server-based schemes to peer-to-peer systems for videodelivery. In such systems, video data is delivered to the users by utilizing theresources of the users themselves, leading to a potentially scalable solution.Users connect to each other, forming a p2p overlay network on top of theInternet and exchange the video segments among themselves. The performanceof a p2p system is characterized by its capability to deliver the videocontent to all peers without errors and with the smallest possible delay. Thisconstitutes a challenge since peers dynamically join and leave the overlay andalso contribute different amounts of resources to the system.The contribution of this thesis lies in two areas. The first area is theperformance evaluation of the most prominent p2p streaming architectures.We study the streaming quality in multiple-tree-based systems. We derivemodels to evaluate the stability of a multiple tree overlay in dynamic scenariosand the efficiency of the data distribution over the multiple trees. Then, westudy the data propagation in mesh-based overlays. We develop a generalframework for the evaluation of forwarding algorithms in such overlays anduse this framework to evaluate the performance of four different algorithms.The second area of the thesis is a study of streaming in heterogeneous p2poverlays. The streaming quality depends on the aggregate resources that peerscontribute to the system: low average contribution leads to low streamingquality. Therefore, maintaining high streaming quality requires mechanismsthat either prohibit non-contributing peers or encourage contribution. In thisthesis we investigate both approaches. For the former, we derive a model tocapture the evolution of available capacity in an overlay and propose simpleadmission control mechanisms to avoid capacity drainage. For the latter, inour last work, we propose a novel incentive mechanism that maximizes thestreaming quality in an overlay by encouraging highly contributing peers tooffer more of their resources.
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Bjørnsen, Stig Inge Lea y Erik Vivhovde Lohne. "Streaming i P2P-nettverk". Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2004. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-265.
Texto completoRealisering av streamingtjenester i P2P-nettverk er en utfordring fordi slike nettverk er preget av dynamikk og stadige endringer i forhold til nodenes tilgjengelighet. Hvis en node som leverer en mediestrøm blir utilgjengelig, vil det oppstå avbrudd i avspillingen hos mottakernoden. Utgangspunktet for denne hovedoppgaven er et ønske om å kunne gjøre streaming med tilfredsstillende tjenestekvalitet til en realitet i P2P-nettverk. Målet er å spesifisere en metode som bidrar til å forbedre den opplevde ressurstilgjengeligheten i slike nettverk.
P2P-systemer kjennetegnes generelt ved at de består av noder på randen av Internett, at samtlige noder bidrar med ressurser og kommuniserer direkte med hverandre og at hver node er en selvstyrende enhet. Det finnes to hovedkategorier P2P-systemer, “ekte” og “hybride”, samt en rekke applikasjonsområder. Streaming innebærer at innholdsleveranse gjøres i sanntid. Sanntidsleveranse krever at data leveres til mottaker i tide og at pakker leveres i rett rekkefølge. I P2P-nettverk, hvor omgivelsene preges av dynamikk og heterogenitet, er dette en stor utfordring. Flere teknikker kan benyttes for å håndtere slike omgivelser, men utfordringene knyttet til tilgjengelighet framstår som uløste og samtidig kritiske med tanke på oppnåelig tjenestekvalitet.
Vårt bidrag i retning av å forbedre den opplevde ressurstilgjengeligheten er en metode som blant annet benytter multinodestreaming som leveranseteknikk. Multinodestreaming innebærer å dele en strøm i flere delstrømmer og hente disse fra forskjellige noder. Delstrømmene kan da flettes ved mottak og spilles av som én strøm. Konsekvensen av at en node blir utilgjengelig vil kun bli kvalitetsdegradering av avspillingen, og ikke totalt avspillingsbrudd. Tilgjengeligheten kan forbedres ytterligere ved å utføre effektiv overtakelse av tapte delstrømmer. Ved å implementere metoden i en prototyp, er det mulig å teste dens funksjon og effekt. Testene viser at kvalitetsdegraderingen på avspillingen, som følge av at en node blir utilgjengelig, kun er midlertidig hvis en annen node kan overta leveransen. Reetablering av en delstrøm kan gjøres på gjennomsnittlig 4,7 sekunder. Enkeltnodestreaming ville til sammenligning medført fullt avspillingsbrudd. Resultatene sannsynliggjør derfor at multinodestreaming kan bidra til å forbedre den opplevde ressurstilgjengeligheten for streamingtjenester i P2P-nettverk.
Merzky, Alexander. "Einführung in P2P-Netzwerke". Universitätsbibliothek Chemnitz, 2002. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200200476.
Texto completoGemeinsamer Workshop von Universitaetsrechenzentrum und Professur Rechnernetze und verteilte Systeme der Fakultaet fuer Informatik der TU Chemnitz. Vergleich zentrale, semizentrale und dezentrale Kommunikation, Spezifikation eines P2P-Protokolls des Gnutella-Netzes (PING, PONG, QUERY, QUERY-HIT, PUSH - Pakete) Die graphische Oberflaeche Limewire und deren Struktur
Hübner, Uwe. "Klassifizierung von P2P-Anwendungen". Universitätsbibliothek Chemnitz, 2002. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200200694.
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