Tesis sobre el tema "Organic Synthessis"
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Paradis, Michel 1976. "The design and synthessis of platinum-based DNA intercalators /". Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31523.
Texto completoInert and stable transition-metal complexes are already being used for this purpose. Square planar platinum (II) complexes containing an aromatic heterocyclic ligand can insert and stack between the double helix base pairs. Two known ligands, DPPZ and phi, do intercalate DNA when chelating ruthenium, rhodium, or osmium.
Here are presented the syntheses of [Pt(NH3)2DPPZ](CF 3SO3)2, [Pt(en)DPPZ](CF3SO3) 2, [Pt(phen)DPPZ](CF3SO3)2, [Pt(Me 2bpy)DPPZ](CF3SO3)2, and [Pt(phendione)DPPZ](CF 3SO3)2, and the attempted syntheses of [Pt(en)phi](PF 6)2 and [Pt(phen)phi](PF6)2. The binding constants of [Pt(NH3)2DPPZ](CF3SO3) 2 and [Pt(en)DPPZ](CF3SO3)2 to calf thymus DNA have been determined. The knowledge coming from the synthetic strategy to obtain monomers has allowed the synthesis of a platinum-based dimer, [(DPPZ)Pt{DPPZ(11-11 ')DPPZ}Pt(DPPZ)](CF3SO3)4, having two intercalative DPPZ ends. We hope that this bis-intercalator will bring into close proximity two DNA strands.
Phung, Bich Tuyen. "Etude de la sélectivité dans la réaction de Buchner". Electronic Thesis or Diss., Université Grenoble Alpes, 2024. https://theses.hal.science/tel-04651531.
Texto completoThe work presented in this manuscript is divided into two main parts. Firstly, a study about the problem of chemoselectivity during the intramolecular carbene transfer reaction will be presented. The diazo compound bearing different substituent was synthesized as precursor of carbene, and then the carbene transfer reaction was performed in the presence of the Rh2(OAc)4 catalyst. The result displayed the competition between Buchner reaction and C‒H insertion reaction at benzylic position, depended on the substituent. DFT calculations were subsequently conducted to complete the information obtained experimentally. The second major focus of this manuscript involves exploring the reactivity of N-sulfonyl-1,2,3-triazole. N-sulfonyl-1,2,3-triazole precursors were generated using the CuAAC method. The intermolecular formal [3+2] cycloaddition reaction with aromatics catalysed by chiral Rh(II) was then studied
Trupina, Snjezana. "Synthesis of Metalloporphyrins with Oligothiophenes as Probes for Amyloid Diseases". Thesis, Linköping University, Linköping University, Organic Chemistry, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57989.
Texto completoAbnormal aggregation of misfolded proteins is related to numerous neurodegenerative diseases, which include Alzheimer’s, Parkinson’s disease and prion diseases. Luminescent conjugated probes (LCPs) have been used as dyes for these supramolecular assemblies termed amyloid fibrils. To these probes, metalloporphyrin (MP) derivates have been attached to achieve new spectroscopic properties, which will allow for new ways to study protein aggregation diseases.
In this thesis the synthesis of two different LCPs anchored porphyrin derivates are described. The LCPs are synthesized from 3-thiopheneacetic acid and additional thiophene units are added with the use of Suzuki cross coupling reaction. The porphyrin is synthesized from pyrrol, benzaldehyde and methyl-4- formylbenzoate in a condensation reaction. In the first target molecule (TM) the porphyrin and thiophene are coupled with a spacer and the second one is a direct coupling between the two compounds.
Tilliet, Mélanie. "Synthesis and study of new oxazoline-based ligands". Doctoral thesis, KTH, Organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4858.
Texto completoQC 20100914
Winberg, Karl Johan. "Carborane Derivatives for Nuclide Therapy and Imaging : Synthesis and Radio-labelling". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3561.
Texto completoFyrner, Timmy. "Synthesis of Structures Related to Antifreeze Glycoproteins". Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11941.
Texto completoIn this thesis, synthesis of structures related to antifreeze glycoproteins (AFGPs) are presented. Synthetic routes to a protected carbohydrate derivative, 2,3,4,6-tetra-O-benzyl-β-galactopyranosyl-(1→3)-2-deoxy-2-azido-4,6-di-O-benzyl-β-D-thio-1-galactopyranoside, and a tBu-Ala-Thr-Ala-Fmoc tripeptide, are described. These compounds are meant to be used in the assembly of AFGPs and analogues thereof. A Gal-GlcN disaccharide was synthesized via glycosylation between the donor, bromo-2-O-benzoyl-3,4,6-tri-O-benzyl-α-Dgalactopyranoside, and acceptor, ethyl 4,6-O-benzylidene-2-deoxy-2-N-phthalimido-β-D-1-thio-glucopyranoside, using silver triflate activation. Subsequent epimerization to a Gal-GalN disaccharide was achieved using Moffatt oxidation followed by L-selectride® reduction. The tripeptide was synthesized in a short and convenient manner using solid phase peptide synthesis with immobilized Fmoc-Ala on Wang® resins as starting point.
Larsson, Andreas. "Synthesis, structure and conformation of oligo- and polysaccharides". Doctoral thesis, Stockholm University, Department of Organic Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-172.
Texto completoCarbohydrates are a complex group of biomolecules with a high structural diversity. Their almost omnipresent occurrence has generated a broad field of research in both biology and chemistry. This thesis focuses on three different aspects of carbohydrate chemistry, synthesis, structure elucidation and the conformational analysis of carbohydrates.
The first paper describes the synthesis of a penta- and a tetrasaccharide related to the highly branched capsular polysaccharide from Streptococcus pneumoniae type 37. In the second paper, the structure of the O-antigenic repeating unit from the lipopolysaccharide of E. coli 396/C1 was determined along with indications of the structure of the biological repeating unit. In addition, its structural and immunological relationship with E. coli O126 is discussed. In the third paper, partially protected galactopyranosides were examined to clarify the origin of an intriguing 4JHO,H coupling, where a W-mediated coupling pathway was found to operate. In the fourth paper, the conformation of methyl a-cellobioside is studied with a combination of molecular dynamics simulations and NMR spectroscopy. In addition to the expected syn-conformation, detection and quantification of anti-ø and anti-ψ conformers was also possible.
Esfandiarfard, Keyhan. "Novel Organophosphorus Compounds for Materials and Organic Synthesis". Doctoral thesis, Uppsala universitet, Molekylär biomimetik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328295.
Texto completoBERTON, GIACOMO. "SYNTHESIS OF TRIPHENYLENES FOR SUPRAMOLECULAR APPLICATIONS". Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2969361.
Texto completoHagberg, Daniel. "Synthesis of Organic Chromophores for Dye Sensitized Solar Cells". Licentiate thesis, Stockholm : Kemi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4600.
Texto completoGemma, Emiliano. "Synthesis of Oligosaccharides for Interaction Studies with Various Lectins". Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-459.
Texto completoEriksson, Tor. "Synthesis of 2-(ethoxy(hydroxy)phosphoryl)-3-phenylpropyl ethanethioate". Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-386474.
Texto completoVelikyan, Irina. "Synthesis, Characterization and Application of 68Ga-labelled Peptides and Oligonucleotides". Licentiate thesis, Uppsala University, Department of Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-86136.
Texto completoThe positron emitting 68Ga radionuclide (T1/2 = 68 min) has the potential of practical interest for clinical PET. The metallic cation, 68Ga3+, is suitable for complexation reactions with chelators either naked or conjugated with macromolecules such as peptides and oligonucleotides. Such labeling procedures require pure and concentrated radiometal preparations, which cannot be sufficiently fulfilled by the presently available 68Ge/68Ga generator eluate. This thesis presents a method to increase the concentration and purity of 68Ga obtained from a commercial 68Ge/68Ga generator. DOTATOC (DOTA = 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid, TOC = D-Phe1-Tyr3–Octreotide) was used as a test molecule for comparing the labeling properties of different 68Ga preparations. In addition, DOTA-RDG (RGD = Cys2-6; c[CH2CO-Lys(DOTA)-Cys-Arg-Gly-Asp-Cys-Phe-Cys]-CCX6-NH2) and NODAGATATE (NODAGA = 1,4,7-triazacyclononane-1,4,7-triacetic, TATE = Tyr3 - Octreotate) were used to prove the concept. The use of the concentrated and purified 68Ga eluate along with microwave activation allowed quantitative 68Ga-labelling of peptide conjugates of ≤1 nanomolar quantities within 10 min. The specific radioactivity of the radiolabelled peptides was improved by a factor of >100 compared to previously applied techniques using non-treated generator eluate and conventional heating. A commercial 68Ge/68Ga generator in combination with this method for purification, concentration and microwave activated labeling resulted in a kit technology for 68Ga-tracer production.Four 17-mer oligonucleotides modified and functionalised with an hexylamine group in the 3'- or 5'- position were conjugated with DOTA and labelled with 68Ga using microwave activation. Chemical modification of the oligonucleotide backbone or sugar moiety did not influence the labelling nor the hybridisation ability of the oligonucleotides. However, the radioactivity organ biodistribution in rats differed dependent on the oligonucleotide structure. This indicated that metabolism and non-specific binding were affected by the backbone and sugar moiety structure.
Ayesa, Alvarez Susana. "Design and Synthesis of Amine Building Blocks and Protease Inhibitors". Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8038.
Texto completoWallner, Olov. "Palladium-Catalyzed Synthesis and Transformations of Organometallic Compounds". Doctoral thesis, Stockholm : Dept. of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-804.
Texto completoTorssell, Staffan. "Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis". Licentiate thesis, KTH, Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-315.
Texto completoThis thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. Utilizing a highly diastereoselective Rh(II)-catalyzed 1,3-dipolar cycloaddition of carbonyl ylides to various aldimines, syn-α-hydroxy-β-amino esters formed in high yields and excellent diastereoselectivities. This methodology was also applied in a short enantioselective synthesis of the C-13 side-chain of Taxol.
The second part of the thesis describes a total synthesis of D-erythro- Sphingosine based on a cross-metathesis approach to assemble the polar head group and the aliphatic chain.
The last part deals with the application of amino alcohols as scaffolds in a diversity-oriented protocol for the development of libraries of small polycyclic molecules. The design of the libraries is based on the iterative use of two powerful ring-forming reactions; a ring-closing metathesis and an intramolecular Diels-Alder reaction, to simultaneously introduce structural complexity and diversity.
Ahmed, Mustafe. "Synthesis of imidazopyridazine analogs aiming to improve antibacterial Gram-negative activity". Thesis, Uppsala universitet, Institutionen för läkemedelskemi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449572.
Texto completoModin, Judit. "Synthesis and Evaluation of Photoactive Pyridine Complexes for Electron Transfer Studies and Photoelectrochemical Applications". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6146.
Texto completoO'Neill, Bridget. "Syntheses of novel 2-oxo esters : enzyme substrates designed for asymmetric synthesis". Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261316.
Texto completoLamprianidis, Panagiotis. "Photoredox catalysis with 10-phenyl-10H- phenothiazine and synthesis of a photocatalytic chiral proline-based organocatalyst". Thesis, KTH, Organisk kemi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-293510.
Texto completoApplikationer av photoredox-katalys med syftet att generera nya syntetiska vägar inom organisk och hållbar kemi är populära ämnen i organisk syntes idag. I denna studien undersöktes för första gången syntesen av en kiral prolinbaserad organokatalysator som är funktionaliserad med fotokatalytiska enheter (10-fenyl-10H-fenotiazin (PTH)). Den fotokatalytiska aktiviteten av PTH studerades för olika organiska reaktioner, såsom t.ex. dehalogenering av aromatiska halider och pinacolkopplingar mellan aromatiska aldehyder. Dessa transformationer är annars svåra att uppnå utan en lämplig fotokatalysator och reaktionerna utfördes med måttliga till höga utbyten.
Alfredsson, Maria. "Synthesis and Characterization of Acrylfentanyl Metabolites". Thesis, Linköpings universitet, Kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138142.
Texto completoErlandsson, Maria. "Imaging of Enzymes in the Steroid Biosynthetic Pathway : Synthesis of 18F-Labelled Tracers". Doctoral thesis, Uppsala universitet, Organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89177.
Texto completoSantangelo, Ellen M. "Stereoselective syntheses of semichemicals : Applications in ecological chemistry". Doctoral thesis, KTH, Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-74.
Texto completoThis thesis describes the syntheses of semiochemicals and their applications in the development of control methods for pest insects. The compounds synthesized are divided into three groups: 1) Lepidoptera pheromones; 2) methyl substituted chiral pheromones and 3) aphid pheromones.
Different purification techniques have been explored in order to provide > 99% pure semiochemicals for field tests. Examples of the techniques are uses of urea inclusion complexes, argentum chromatography, low temperature crystallization and what we call the Baeckström isolation technique.
Iridoids have been produced in a synthetic strategy including an intramolecular enal-enamine [4+2] cycloaddition, a dynamic acetylation and an enantioselective transesterification mediated by a lipase from Pseudomonas cepacia. The use of chiral auxiliaries to perform the intramolecular [4+2] cycloaddition has also been investigated. A useful asymmetric route to iridoids has been developed.
Karimi, Farhad. "[11C]Carbon Monoxide in Palladium- / Selenium-Promoted Carbonylation Reactions : Synthesis of 11C-Imides, Hydrazides, Amides, Carboxylic Acids, Carboxylic Esters, Carbothioates, Ketones and Carbamoyl Compounds". Doctoral thesis, Uppsala universitet, Avdelningen för organisk kemi, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2931.
Texto completoSjölin, Olof. "Synthesis of Substituted Pyrrolidines". Thesis, KTH, Skolan för kemivetenskap (CHE), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207056.
Texto completoSonesten, Victor. "Design and Synthesis of Macrocyclic Peptides as Potential Inhibitors of Lysine-Specific Demethylase 1". Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397428.
Texto completoToom, Lauri. "Bispidine Derivatives : Synthesis and Interactions with Lewis Acids". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6735.
Texto completoThorstensson, Fredrik. "Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library". Doctoral thesis, Linköping : Linköpings universitet, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-4938.
Texto completoTeodorovic, Peter. "Synthesis of oligosaccharides related to the capsular polysaccharide of Neisseria meningitidis serotype A". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-545.
Texto completoAdrian, Meredith Jenny. "Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29773.
Texto completoAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Submitted. Paper 2: Submitted. Paper 3: Manuscript.
Kalek, Marcin. "Synthesis of C(sp2)-P bonds by palladium-catalyzed reactions : Mechanistic investigations and synthetic studies". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56467.
Texto completoAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 7: In press.
Tan, Changqing. "Photochemical Silaylide, Silylene and Silene Syntheses". Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc501256/.
Texto completoEricsson, Cecilia. "Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4018.
Texto completoKarimi, Farhad. "[11C]Carbon Monoxide in Palladium- / Selenium-Promoted Carbonylation Reactions : Synthesis of 11C-Imides, Hydrazides, Amides, Carboxylic Acids, Carboxylic Esters, Carbothioates, Ketones and Carbamoyl Compounds". Doctoral thesis, Uppsala University, Organic Chemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2931.
Texto completo[11C]Carbon monoxide in low concentrations has been used in palladium- or seleniummediated carbonylation reactions such as the synthesis of 11C-imides, hydrazides, amides, carboxylic acids, esters, carbothioates, ketones and carbamoyl compounds.
In these reactions aryl iodides have been used in most cases. However, less reactive aryl triflate, chloride and bromides were activated using tetrabutylammonium iodide.
The reactivities of nucleophiles may have influence on the radiochemical yield of the 11Clabelled compounds. Carboxyamination of aryl halides using aniline derivatives yielded 10% of the corresponding 11C-amide. However, the radiochemical yields increased significantly when the aniline derivatives were treated with lithium bis(trimethylsilyl)amide. In contrast, this reagent did not improve the radiochemical yields when primary amines such as methylamine and benzylamine were used. In these cases the radiochemical yields were improved by using pempidine.
11C-Esterification usually gave low yields. However, the radiochemical yields of 11C-esters could be improved by using magnesium bromide and pempidine.
An excess of ligand may have a significant impact on palladium-promoted carbonylation reaction. The radiochemical yields of 11C-ketones were improved when using excess amounts of tri-o-tolylphosphine.
(13C)Carbon monoxide may be utilized for the synthesis of 13C-substituated compounds in order to confirm the position of 11C-labelling.
Larsson, Michael. "Natural products from nonracemie building blocks : synthesis of pine sawfly pheromones". Doctoral thesis, KTH, Kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128.
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Sebelius, Sara. "Palladium-Catalyzed Synthesis and Transformation of Organoboranes". Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1198.
Texto completoDesai, Bimbisar. "Microwave assisted organic synthesis". Thesis, University of Surrey, 2002. http://epubs.surrey.ac.uk/842821/.
Texto completoSarkar, Achintya Kumar. "Allylsilanes in organic synthesis". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292242.
Texto completoHetherington, Peter. "Organic synthesis with bromonitromethane". Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317552.
Texto completoShort, Robert Paul 1951. "Organoboranes in organic synthesis". Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/14204.
Texto completoO'Rourke, Christopher. "Photocatalysis for organic synthesis". Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675420.
Texto completoWångsell, Fredrik. "Design and Synthesis of Serine and Aspartic Protease Inhibitors". Licentiate thesis, Linköping University, Linköping University, Organic Chemistry, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7372.
Texto completoThis thesis describes the design and synthesis of compounds that are
intended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. The NS3 protease, encoded by HCV, is essential for replication of the virus and has become one of the main targets when developing drugs to fight HCV. The inhibitors discussed here constitute surrogates for the widely used N-acyl-hydroxyproline isostere designated 4-hydroxy-cyclopentene. The stereochemistry of the 4-hydroxy-cyclopentene scaffold was determined by nuclear overhauser effect spectroscopy (NOESY) and the regiochemistry by heteronuclear multiple bond correlation (HMBC). The scaffold was decorated with different substituents to obtain both linear and macrocyclic HCV NS3 protease inhibitors that display low nanomolar activity. The second part of the thesis describes the design and synthesis of potential aspartic protease inhibitors. The hydroxyethylene motif was used as a noncleavable transition state isostere. The synthetic route yielded a pivotal intermediate with excellent stereochemical control, which was corroborated by NOESY experiments. This intermediate can be diversified with different substituents to furnish novel aspartic protease inhibitors.
Report code: LIU-TEK-LIC-2006:45
Mitra, Soumya. "Total synthesis of gomisin O asymmetric total syntheses of eupomatilones 1, 2 and 5; and studies towards total synthesis of mayolide A /". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189449580.
Texto completoNimkar, Sandeep Krishnaji. "Studies in asymmetric synthesis: Development of new synthetic methods for syntheses of natural products". Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186538.
Texto completoPirovano, V. "GOLD-CATALYZED SYNTHESIS AND FUNCTIONALIZATION OF HETEROARENES". Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232413.
Texto completoSaarinen, Gabrielle. "Development of Synthetic Routes for Preparation of 2,6-Disubstituted Spiro[3.3]heptanes". Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-6027.
Texto completo2,6-Disubstituted spiro[3.3]heptanes were synthesized to investigate and develop synthetic methods for preparation of these compounds. Possibilities for introducing different functionalities like nitriles and sulfonamides were also investigated.
Synthetic routes presented describe successive [2+2] cycloadditions between dichloroketene and olefins to give the sought after spiro compounds with low to moderate yields throughout the multi-step synthesis. [2+2] Cycloadditions offered low turnovers and chromatography was required for purification.
A synthetic route with cyclisations through double substitution reactions between di-electrophiles and di-nucleophiles resulting in a 2,6-disubstituted spiro[3.3]heptane is also described. This multi-step synthesis offered higher turnover and yields and often there was no need for purification through chromatography.
Modin, Stefan. "Developments in the Field of Aza-Diels-Alder Reactions, Catalytic Michael Additions and Automated Synthesis". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, Univ.bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4640.
Texto completoSaito, Yu. "Synthesis of bioactive compounds: Synthetic study of D-Lac-terminated peptidoglycan fragment structures". Thesis, KTH, Kemiteknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-300085.
Texto completoPeptidoglycan (PGN) is a bacterial cell wall component and known to be recognized by various receptors or enzymes to lead the activation immune system. The general structure of PGN consists of sugar chains including N-acetylglutamine (GlcNAc), N-acetylmuramic acid (MurNAc) and cross-linked peptide chains. PGN fragments having D-Lac terminus peptides have been found from vancomycin-resistant enterococcus, but a chemically synthesized PGN fragment having a D-Lac terminus peptide has not been examined in detail. Thus, we focused on the synthesis of PGN fragment structures that include a D-Ala-D-Lac residue at the terminal part of the peptide chain. In order to synthesize these fragment structures, we planned to combine solid-phase synthesis (for the peptide- Lac part) and solution-phase synthesis (for glycan preparation and the condensation). This approach is advantageous for the preparation of peptidoglycan fragments having complex branched peptide moiety. First, we prepared the sugar moiety MurNAc derivative in solution-phase synthesis from a glucose derivative. While, the Lac-containing peptide was prepared with solid-phase peptide synthesis using 2-chlorotrityl chloride resin. Having this compound, the condensation of these two compounds gave the desired D-Lac-terminated peptidoglycan fragment.
Alibhai, Najma. "Part A. The syntheses of dillapiol and its 4-thio derivatives, Part B. The synthesis of trichiliasterone B". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/MQ48124.pdf.
Texto completoMojica, Mike. "Investigation of new synthetic reactions: the synthesis of hydrazines via the Aza-Lossen rearrangement, the synthesis of carbamoyl azides from amines, and deprotection reactions using water at elevated temperatures". Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51791.
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