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1

Ariefin, Mokhamat y Vety Sri Harlinda Ayudha. "Synthesis and Characterization of Benzodithiophene (BDT) Quinoid Compounds as a Potential Compound for n-Type Organic Thin-Film Transistors (OTFT)". Jurnal Kimia Sains dan Aplikasi 23, n.º 7 (17 de julio de 2020): 261–66. http://dx.doi.org/10.14710/jksa.23.7.261-266.

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Two potential compounds as an n-Type organic thin-film transistor (OTFT) from benzodithiophene (BDT) derivatives have been synthesized and characterized. BDT was chosen as the core because it has π-conjugated bonds, rigid structures, and planar. Quinoid structure with end-cap (terminal group) in the form of dicyanomethylene is used because it can lower the LUMO value of the compound, and side chains are selected in the form of alkoxy so that two BDT derivatives are obtained namely BDTQ-6 (hexyloxy) and BDTQ-10 (decyloxy). Based on the results of TGA, BDTQ-6 and BDTQ-10 have decomposition points of 183°C and 203°C, which indicate the compound has excellent thermal stability. From the UV-Vis measurement, the λmax value of the two compounds is 599 nm with optical gap energy (Eg°pt) of 1.7 eV. From the DPV measurement, the LUMO value for the two compounds is -4.3 eV, with an energy gap (Eg) of 1.69 eV (BDTQ-6) and 1.70 eV (BDTQ-10). Based on observations of the crystal structure through x-ray diffraction, it was found that the BDTQ-10 crystal has a "brick type" layer arrangement with a distance between layers of 3.55 Å. With excellent thermal stability and suitable LUMO values and energy gaps, it is expected that BDTQ-6 and BDTQ-10 compounds have the potential to be n-Type OTFT materials.
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2

Lobzhanidze, Tea. "Synthesis, Study and Use of New Type Biologically Active Arsenic-Organic Complex Compounds". Chemistry & Chemical Technology 6, n.º 4 (20 de diciembre de 2012): 371–76. http://dx.doi.org/10.23939/chcht06.04.371.

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3

MURAHASHI, Shun-Ichi y Takeshi NAOTA. "Organic synthesis using ruthenium compounds." Journal of Synthetic Organic Chemistry, Japan 46, n.º 10 (1988): 930–42. http://dx.doi.org/10.5059/yukigoseikyokaishi.46.930.

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4

KUSAMA, Hiroyuki y Koichi NARASAKA. "Rhenium Compounds in Organic Synthesis." Journal of Synthetic Organic Chemistry, Japan 54, n.º 8 (1996): 644–53. http://dx.doi.org/10.5059/yukigoseikyokaishi.54.644.

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5

SHINOKUBO, Hiroshi y Koichiro OSHIMA. "Organic Synthesis Using Organomanganese Compounds". Journal of Synthetic Organic Chemistry, Japan 57, n.º 1 (1999): 13–23. http://dx.doi.org/10.5059/yukigoseikyokaishi.57.13.

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6

Negishi, Ei-ichi y Tamotsu Takahashi. "Organozirconium Compounds in Organic Synthesis". Synthesis 1988, n.º 01 (1988): 1–19. http://dx.doi.org/10.1055/s-1988-27453.

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7

Sadekov, Igor D., B. B. Rivkin y Vladimir I. Minkin. "Organotellurium Compounds in Organic Synthesis". Russian Chemical Reviews 56, n.º 4 (30 de abril de 1987): 343–54. http://dx.doi.org/10.1070/rc1987v056n04abeh003275.

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8

Khusnutdinov, R. I., T. M. Oshnyakova y U. M. Dzhemilev. "Molybdenum compounds in organic synthesis". Russian Chemical Reviews 86, n.º 2 (28 de febrero de 2017): 128–63. http://dx.doi.org/10.1070/rcr4617.

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9

Jiao, Jiao y Yasushi Nishihara. "Alkynylboron compounds in organic synthesis". Journal of Organometallic Chemistry 721-722 (diciembre de 2012): 3–16. http://dx.doi.org/10.1016/j.jorganchem.2012.05.027.

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10

Knölker, H. J. "Iron Compounds in Organic Synthesis". Synthesis 1994, n.º 10 (1994): 1106. http://dx.doi.org/10.1055/s-1994-25646.

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11

Eaborn, Colin. "Organoboron Compounds in Organic Synthesis". Journal of Organometallic Chemistry 284, n.º 2 (abril de 1985): C43. http://dx.doi.org/10.1016/0022-328x(85)87227-2.

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12

Birch, Arthur J., Brian Chauncy, Lawrence F. Kelly y David J. Thompson. "Organometallic compounds in organic synthesis". Journal of Organometallic Chemistry 286, n.º 1 (abril de 1985): 37–46. http://dx.doi.org/10.1016/0022-328x(85)87233-8.

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13

Chaloner, Penny A. "Organomercury compounds in organic synthesis". Journal of Organometallic Chemistry 307, n.º 1 (junio de 1986): C10—C11. http://dx.doi.org/10.1016/0022-328x(86)80188-7.

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14

Petasis, N. A., S. P. Lu, E. I. Bzowej, D. K. Fu, J. P. Staszewski, Irini Akritopoulou-Zanze, M. A. Patane y Y. H. Hu. "Organotitanium compounds in organic synthesis". Pure and Applied Chemistry 68, n.º 3 (1 de enero de 1996): 667–70. http://dx.doi.org/10.1351/pac199668030667.

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15

Roberts, R. M. G. "Iron compounds in organic synthesis". Journal of Organometallic Chemistry 490, n.º 1-2 (marzo de 1995): C37. http://dx.doi.org/10.1016/0022-328x(95)90297-r.

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16

Mamedov, E. Sh, T. N. Kulibekova, D. S. Veliyeva, Z. S. Safaraliyeva y I. R. Rushinaz. "SYNTHESIS OF S,P,N-CONTAINING ORGANIC COMPOUNDS AND THEIR THERMOSTABILITY WITH RESPECT TO METALS". Azerbaijan Chemical Journal, n.º 4 (14 de noviembre de 2023): 97–103. http://dx.doi.org/10.32737/0005-2531-2023-4-97-103.

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The results of thermal studies of some derivatives of dithiophosphoric, xanthogenic, dithiocarbamic acids are presented. The thermal parameters of the compounds were determined both in pure form and in the presence of iron and copper powders. Their chemical activity with respect to iron and copper was studied. It has been found that the temperature at which the thermal stability of the studied compounds is maintained exceeds 1700С, and they are chemically active with respect to iron and copper: the lower the interaction temperature within the same row with iron and copper and the lower its mass loss corresponding to this temperature, the more effective it is like an extreme pressure (EP) additive. It has been found that compounds of the same series, reacting with metal by the type of synchronous and exchange reactions, have better indicators of extreme pressure properties than compounds interacting with metal by the type of asynchronous reaction
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17

Macarie, Lavinia, Nicoleta Plesu, Smaranda Iliescu y Gheorghe Ilia. "Synthesis of organophosphorus compounds using ionic liquids". Reviews in Chemical Engineering 34, n.º 5 (28 de agosto de 2018): 727–40. http://dx.doi.org/10.1515/revce-2017-0014.

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Abstract Organophosphorus chemistry was developed in the last decade by promoting the synthesis reactions using ionic liquids either as solvent or catalyst. Ionic liquids (ILs), the so-called “green solvents”, have gained interest in the synthesis of organophosphorus compounds as alternatives to flammable and toxic organic solvents and catalysts. ILs have beneficial properties because they provide high solubility for many organic and inorganic compounds or metal complexes, have no vapor pressure, and are reusable. Also, in some cases, they can enhance the reactivity of chemical reagents. In this review, we aimed at showing the synthesis of different organophosphorus compounds under green and mild conditions using ILs as reaction media or catalysts, according to a trend developed in the last years. A novel trend is to perform these syntheses under microwave irradiation conditions together with ILs as solvents and catalysts.
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18

Reeves, Eoghan P. y Jens Fiebig. "Abiotic Synthesis of Methane and Organic Compounds in Earth’s Lithosphere". Elements 16, n.º 1 (1 de febrero de 2020): 25–31. http://dx.doi.org/10.2138/gselements.16.1.25.

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Accumulation of molecular hydrogen in geologic systems can create conditions energetically favorable to transform inorganic carbon into methane and other organic compounds. Although hydrocarbons with a potentially abiotic origin have been proposed to form in a number of crustal settings, the ubiquitous presence of organic compounds derived from biological organic matter presents a challenge for unambiguously identifying abiotic organic molecules. In recent years, extensive analysis of methane and other organics in diverse geologic fluids, combined with novel isotope analyses and laboratory simulations, have, however, yielded insights into the distribution of specific abiotic organic molecules in Earth’s lithosphere and the likely conditions and pathways under which they form.
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19

Fajdek-Bieda, Anna y Andrzej Perec. "Optimization of the organic compounds synthesis". Procedia Computer Science 207 (2022): 819–28. http://dx.doi.org/10.1016/j.procs.2022.09.137.

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20

Gouverneur, Véronique, Sophie Boldon, Ida Stenhagen, Jane Moore y Sajinder Luthra. "Supported Synthesis of Halogenated Organic Compounds". Synthesis 2011, n.º 24 (8 de noviembre de 2011): 3929–53. http://dx.doi.org/10.1055/s-0031-1289590.

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21

Wirth, Thomas. "Chiral selenium compounds in organic synthesis". Tetrahedron 55, n.º 1 (enero de 1999): 1–28. http://dx.doi.org/10.1016/s0040-4020(98)00946-6.

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22

Peppe, C. "Indium(I) Compounds in Organic Synthesis". Current Organic Synthesis 1, n.º 3 (1 de julio de 2004): 227–31. http://dx.doi.org/10.2174/1570179043366657.

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23

DOCKX, Jozef. "Quaternary Ammonium Compounds in Organic Synthesis". Synthesis 1973, n.º 08 (12 de septiembre de 2002): 441–56. http://dx.doi.org/10.1055/s-1973-22233.

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24

Yoneda, Norihiko, Tsuyoshi Fukuhara, Yukio Takahashi y Mitsuhiro Okimoto. "Electrochemical Synthesis of Fluoro-Organic Compounds Using Iodine Compounds". ECS Transactions 2, n.º 22 (21 de diciembre de 2019): 1–6. http://dx.doi.org/10.1149/1.2408998.

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25

Samaritdinovna, Tursunova Nargiza, Shukurov Sardor Salimovich y Asatova Marjona Otabekovna. "TECHNOLOGY FOR OBTAINING INORGANIC AND ORGANIC SEMICONDUCTOR COMPOUNDS FOR SOLAR CELLS". International Journal of Advance Scientific Research 03, n.º 06 (1 de junio de 2023): 211–16. http://dx.doi.org/10.37547/ijasr-03-06-37.

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This article presents the synthesis of semiconductor polymer materials and their use in photovoltaic technology, the study of one of the promising semiconductors, polyaniline, titanium dioxide deposited on one side on a transparent special glass plate and impregnated with a dye, solar cells obtained based on dyes that are sensitive to sunlight and the power generated by them, the values of voltage and current were measured.
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26

Minko, Yury y Ilan Marek. "Oxenoids in organic synthesis". Org. Biomol. Chem. 12, n.º 10 (2014): 1535–46. http://dx.doi.org/10.1039/c3ob42349b.

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27

Tatrishvili, Tamara y Omar Mukbaniani. "Cyclic Silicon Organic Copolymers: Synthesis and Investigation. Review". Chemistry & Chemical Technology 18, n.º 2 (14 de junio de 2024): 131–42. http://dx.doi.org/10.23939/chcht18.02.131.

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This paper considers the synthesis and investigation of cyclic silicon-organic polymers with mono- and polycyclic fragments in the side chain. For obtaining monocyclic polymers, the hydrosilylation reaction of 1-hydro-3-vinylhexamethylcyclotetrasiloxane was used. The reaction was conducted in a CCl4 solution at 75°C in the presence of Speier’s catalyst (H2PtCl6  6H2O) to produce a viscous-flow at room temperature polymer. The polymers were studied by NMR spectroscopy. Poly(carbosiloxane) with cyclic fragments in the methyl-siloxane backbone was synthesized by the hydride polyaddition of divinylorganocyclosiloxane with dihydrodimethylsiloxane. A semi-quantitative assessment conducted using NMR spectroscopy revealed the ratio of isomeric 1,3- and 1,5-cyclic structures as 1:1. X-ray diffraction studies indicated that copolymers are single-phase amorphous systems. Also, in the review, synthesis and studies of carbosiloxane copolymers containing flexible dimethylsiloxane and decaorganotricyclodecasiloxane fragments in the backbone are discussed. Hydride polyaddition of divinyl-containing compounds was carried out for -dihydridedimethylsiloxanes of various lengths. The synthesized copolymers were characterized by the X-ray diffraction method and TGA.
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28

Jordão, Alessandro K., Maria D. Vargas, Angelo C. Pinto, Fernando de C. da Silva y Vitor F. Ferreira. "Lawsone in organic synthesis". RSC Advances 5, n.º 83 (2015): 67909–43. http://dx.doi.org/10.1039/c5ra12785h.

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29

Arisawa, Mieko y Masahiko Yamaguchi. "Rhodium-Catalyzed Synthesis of Organosulfur Compounds using Sulfur". Synlett 30, n.º 14 (2 de julio de 2019): 1621–31. http://dx.doi.org/10.1055/s-0037-1611867.

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Sulfur is one of the few elements that occurs uncombined in nature. Sulfur atoms are found in natural amino acids and vitamins. In the chemical industry, organosulfur compounds are used for fabricating rubber, fibers, and dyes, pharmaceuticals, and pesticides. Although sulfur, which is cheap and easy to handle, is a useful source of sulfur atom in functional organosulfur compounds, it is rarely used in organic synthesis. Activation of sulfur by high temperature, light irradiation, treatment with nucleophiles and electrophiles, and redox conditions often results in the formation of various active sulfur species, which complicate reactions. The development of a method that mildly activates sulfur is therefore desired. The use of transition-metal catalysts is a new method of activating sulfur under mild conditions, and, in this article, we describe the rhodium-catalyzed synthesis of various organosulfur compounds by the insertion of sulfur atoms into single bonds and by the addition of sulfur to unsaturated bond in various organic compounds.1 Introduction2 Sulfur Activation without using Transition Metal3 Transition-Metal-Catalyzed Activation of Sulfur4 Rhodium-Catalyzed Reactions using Sulfur4.1 Rhodium-Catalyzed Sulfur Atom Exchange Reactions using Sulfur4.2 Synthesis of Diaryl Sulfides using Rhodium-Catalyzed Exchange Reaction of Aryl Fluorides and Sulfur/Organopolysulfides4.3 Rhodium-Catalyzed Synthesis of Isothiocyanate using Sulfur4.4 Rhodium-Catalyzed Sulfur Addition Reaction to Alkenes for Thiiranes Synthesis4.5 Rhodium-Catalyzed Sulfur Addition Reaction to Alkynes for 1,4-Dithiins Synthesis5 Conclusion
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30

Mendoza, Lisbeth, Liadis Bedoya, Elvia V. Cabrera, Dioni Arrieche y Ajoy K. Banerjee. "Polyphosphoric Acid in Organic Synthesis". International Journal of Chemistry 15, n.º 1 (10 de abril de 2023): 47. http://dx.doi.org/10.5539/ijc.v15n1p47.

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Polyphosphoric acid (PPA), a powerful dehydrating agent, has been widely used to perform several important organic reactions and thus has played an important role in the synthesis of organic compounds and natural products. The present micro review describes briefly the use of PPA (i) in the cyclization of acids on the aromatic ring (ii) in acetylation and isopropylation on the aromatic ring, (iii)hydrolysis of esters, (iv) cleavage of epoxides and (v) synthesis of heterocyclic compounds.
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31

Aneeja, Thaipparambil, Sankaran Radhika, Mohan Neetha y Gopinathan Anilkumar. "An Overview of the One-pot Synthesis of Imidazolines". Current Organic Chemistry 24, n.º 20 (2 de diciembre de 2020): 2341–55. http://dx.doi.org/10.2174/1385272824999201001153735.

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One-pot syntheses are a simple, efficient and easy methodology, which are widely used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from imidazolines. The one-pot method is an impressive approach to synthesize organic compounds as it minimizes the reaction time, separation procedures, and ecological impact. Many significant one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran, triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis. This review describes an overview of the one-pot synthesis of imidazolines and covers literature up to 2020.
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32

Aneeja, Thaipparambil, Sankaran Radhika, Mohan Neetha y Gopinathan Anilkumar. "An Overview of the One-pot Synthesis of Imidazolines". Current Organic Chemistry 24, n.º 20 (octubre de 2020): 2341–55. http://dx.doi.org/10.2174/138527282499920100115373.

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One-pot syntheses are a simple, efficient and easy methodology, which are widely used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from imidazolines. The one-pot method is an impressive approach to synthesize organic compounds as it minimizes the reaction time, separation procedures, and ecological impact. Many significant one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran, triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis. This review describes an overview of the one-pot synthesis of imidazolines and covers literature up to 2020.
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33

Li Ran, Li Ran, Deng Yunli Deng Yunli, Wu Siliang Wu Siliang, Liao Jiayi Liao Jiayi, Tang Xiujuan Tang Xiujuan y Han Xiaoxiang Han Xiaoxiang. "Organic-Exchanged Silicotungstic Acid Compounds as Efficient and Environmental-Friendly Catalysts for Synthesis of Glycerol Monolaurate". Journal of the chemical society of pakistan 45, n.º 3 (2023): 243. http://dx.doi.org/10.52568/001244/jcsp/45.03.2023.

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A series of organic-exchanged silicotungstic acid catalysts were synthesized by changing the variety and amount of organic compounds. The structure, thermal stability and acidic properties of the catalysts were characterized by FT-IR, XRD, TGA and 31P-MAS NMR. The catalytic performances of the catalysts were investigated on the selective esterification of lauric acid with glycerol to glycerol monolaurate. Among the various catalysts, [QuH]1H3SiW12O40 with molar ratio of quinoline to silicotungstic acid of 1:1 showed excellent activity and reusability due to strong Brand#248;nsted acidity and “pseudo-liquid” catalytic modes. The optimal conditions optimized by response surface methodology were as follows: the molar ratio of glycerol to lauric acid was 5.3:1, the amount of catalyst was 4.8 wt%, the reaction temperature was 424 K, and the reaction time was 1.5 h. Under these conditions, the average yield of glycerol monolaurate was 79.7%, which was basically consistent with the values predicted by the mathematical model. Moreover, the kinetic data of this reaction were fitted to a second-order kinetic model and the apparent activation energy Ea was 52.35 kJ / mol
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34

Ismail, M. T., M. F. El-Zohry y A. A. Abdel-Wahab. "Electvosynthesis of organic compounds. IV. Synthesis of some arylnitromethane compounds". Journal of Applied Electrochemistry 15, n.º 3 (mayo de 1985): 469–70. http://dx.doi.org/10.1007/bf00616003.

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35

Zhao, Yucheng, Qiang Xiao, Baoqu Wang, Jun Lin y Shengjiao Yan. "Synthesis of Iminopyrrolone Compounds". Chinese Journal of Organic Chemistry 37, n.º 10 (2017): 2696. http://dx.doi.org/10.6023/cjoc201705004.

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36

Gennaiou, Kyriaki, Antonios Kelesidis, Maria Kourgiantaki y Alexandros L. Zografos. "Combining the best of both worlds: radical-based divergent total synthesis". Beilstein Journal of Organic Chemistry 19 (2 de enero de 2023): 1–26. http://dx.doi.org/10.3762/bjoc.19.1.

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A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last two decades, with the evolution of green chemistry and the concepts of atom economy and protecting-group-free synthesis dominating the field of total synthesis. In this new era, total synthesis is moving towards natural efficacy by utilizing both the biosynthetic knowledge of divergent synthesis and the latest developments in radical chemistry. This contemporary review highlights recent total syntheses that incorporate the best of both worlds.
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37

Korzeniowska, Ewelina. "Synthesis of diphenylphosphinic acid esters". Annales Universitatis Mariae Curie-Sklodowska, sectio AA – Chemia 72, n.º 1 (8 de diciembre de 2017): 23. http://dx.doi.org/10.17951/aa.2017.72.1.23.

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<p>The development of new methods for the synthesis of organophosphorus compounds is still an important part of organic chemistry due to the high demand for these compounds in organic synthesis as well as in asymmetric catalysis. Most of the methods for the synthesis of these compounds include the reactivity of the phosphorus atom, which depending on the structure might exhibit both electrophilic and nucleophilic properties. Herein, I will present the results concerning synthesis of diphenylphosphinic acid esters.</p>
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38

Talhi, Oualid y Artur M. S. Silva. "Organic Synthesis of C-Prenylated Phenolic Compounds". Current Organic Chemistry 17, n.º 10 (1 de mayo de 2013): 1067–102. http://dx.doi.org/10.2174/1385272811317100009.

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39

Hanamoto, Takeshi. "Application of Fluoroacetylene Compounds to Organic Synthesis". Journal of Synthetic Organic Chemistry, Japan 69, n.º 9 (2011): 994–1005. http://dx.doi.org/10.5059/yukigoseikyokaishi.69.994.

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40

Ishikura, Minoru. "Applications of Heteroarylboron Compounds to Organic Synthesis". Current Organic Chemistry 6, n.º 6 (1 de mayo de 2002): 507–21. http://dx.doi.org/10.2174/1385272024604907.

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41

WADA, Makoto y Hidenori OHKI. "Organic synthesis using bismuth and bismuth compounds." Journal of Synthetic Organic Chemistry, Japan 47, n.º 5 (1989): 425–35. http://dx.doi.org/10.5059/yukigoseikyokaishi.47.425.

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42

Izumi, Minoru. "Solid-phase organic synthesis of heterocyclic compounds". Journal of Pesticide Science 31, n.º 1 (2006): 1–5. http://dx.doi.org/10.1584/jpestics.31.1.

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43

Fleming, Ian. "Stereocontrol in Organic Synthesis Using Silicon Compounds". Frontiers in Natural Product Chemistry 1, n.º 1 (1 de enero de 2005): 55–64. http://dx.doi.org/10.2174/1574089054583731.

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44

Zhirov, A. M. y A. V. Aksenov. "Azodicarboxylates: synthesis and functionalization of organic compounds". Russian Chemical Reviews 83, n.º 6 (27 de junio de 2014): 502–22. http://dx.doi.org/10.1070/rc2014v083n06abeh004419.

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45

Ford, Alan, Hugues Miel, Aoife Ring, Catherine N. Slattery, Anita R. Maguire y M. Anthony McKervey. "Modern Organic Synthesis with α-Diazocarbonyl Compounds". Chemical Reviews 115, n.º 18 (18 de agosto de 2015): 9981–10080. http://dx.doi.org/10.1021/acs.chemrev.5b00121.

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46

Baran, J. R. y R. J. Lagow. "New general synthesis for polylithium organic compounds". Journal of the American Chemical Society 112, n.º 25 (diciembre de 1990): 9415–16. http://dx.doi.org/10.1021/ja00181a066.

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47

Ye, Tao y M. Anthony McKervey. "Organic Synthesis with .alpha.-Diazo Carbonyl Compounds". Chemical Reviews 94, n.º 4 (junio de 1994): 1091–160. http://dx.doi.org/10.1021/cr00028a010.

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48

Fleming, I. "Stereocontrol in organic synthesis using silicon compounds". Pure and Applied Chemistry 60, n.º 1 (1 de enero de 1988): 71–78. http://dx.doi.org/10.1351/pac198860010071.

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49

Fleming, I. "Stereocontrol in organic synthesis using silicon compounds". Pure and Applied Chemistry 62, n.º 10 (1 de enero de 1990): 1879–86. http://dx.doi.org/10.1351/pac199062101879.

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Shesterenko, E. A. "CARBOXYLESTERASES IN ENANTIOSELECTIVE SYNTHESIS OF ORGANIC COMPOUNDS". Biotechnologia Acta 6, n.º 1 (2013): 9–21. http://dx.doi.org/10.15407/biotech6.01.009.

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