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Literatura académica sobre el tema "Oligomers"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 1 de agosto de 2024

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Artículos de revistas sobre el tema "Oligomers"

Vaikath, Nishant, Indulekha Sudhakaran, Ilham Abdi, Vijay Gupta, Nour Majbour, Simona Ghanem, Houari Abdesselem, Kostas Vekrellis y Omar El-Agnaf. "Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers". International Journal of Molecular Sciences 23, n.º 23 (23 de noviembre de 2022): 14630. http://dx.doi.org/10.3390/ijms232314630.

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The aggregation of α-synuclein (α-syn) into neurotoxic oligomers and fibrils is an important pathogenic feature of synucleinopatheis, including Parkinson’s disease (PD). A further characteristic of PD is the oxidative stress that results in the formation of aldehydes by lipid peroxidation. It has been reported that the brains of deceased patients with PD contain high levels of protein oligomers that are cross-linked to these aldehydes. Increasing evidence also suggests that prefibrillar oligomeric species are more toxic than the mature amyloid fibrils. However, due to the heterogenous and metastable nature, characterization of the α-syn oligomeric species has been challenging. Here, we generated and characterized distinct α-syn oligomers in vitro in the presence of DA and lipid peroxidation products 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE). HNE and ONE oligomer were stable towards the treatment with SDS, urea, and temperature. The secondary structure analysis revealed that only HNE and ONE oligomers contain β-sheet content. In the seeding assay, both DA and ONE oligomers significantly accelerated the aggregation. Furthermore, all oligomeric preparations were found to seed the aggregation of α-syn monomers in vitro and found to be cytotoxic when added to SH-SY5Y cells. Finally, both HNE and ONE α-syn oligomers can be used as a calibrator in an α-syn oligomers-specific ELISA.

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Grewal, Annu, Deepak Sheokand, Vandana Saini y Ajit Kumar. "Molecular docking analysis of α-Synuclein aggregation with Anle138b". Bioinformation 20, n.º 3 (31 de marzo de 2024): 217–22. http://dx.doi.org/10.6026/973206300200217.

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α-Synuclein aggregation into toxic oligomeric species is central to Parkinson痴 disease pathogenesis. Anle138b is a recently identified inhibitor of α-synuclein oligomerization showing promise in preclinical studies. This study employed computational approaches to elucidate Anle138b痴 mechanism of oligomer-specific action. The inhibitory potential of Anle138b against α-synuclein oligomers was evaluated by performing molecular docking studies using AutoDock Tools, followed by their binding pocket analysis. Further, protein-protein docking studies were performed using Hex8.0 to validate the aggregation inhibitory potential of Anle138b. Molecular docking revealed increasing binding affinity of Anle138b against higher order α-synuclein oligomers (dimer to decamer). Anle138b occupied oligomeric cavity and interacted with residues Thr54, Gly73, Val74 and Thr75 across several oligomers. Protein-protein docking showed that Anle138b interferes with α-synuclein decamer formation. These results highlight the oligomer-directed inhibitory mechanism of Anle138b, without hindering the monomeric forms and provide molecular insights to advance its therapeutic development for Parkinson's and related synucleinopathies.

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Wang, Yu, Karen S. L. Lam, Ming-hon Yau y Aimin Xu. "Post-translational modifications of adiponectin: mechanisms and functional implications". Biochemical Journal 409, n.º 3 (15 de enero de 2008): 623–33. http://dx.doi.org/10.1042/bj20071492.

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Adiponectin is an insulin-sensitizing adipokine with anti-diabetic, anti-atherogenic, anti-inflammatory and cardioprotective properties. This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms, including trimeric, hexameric and the HMW (high-molecular-mass) oligomeric complex consisting of at least 18 protomers. Each oligomeric isoform of adiponectin exerts distinct biological properties in its various target tissues. The HMW oligomer is the major active form mediating the insulin-sensitizing effects of adiponectin, whereas the central actions of this adipokine are attributed primarily to the hexameric and trimeric oligomers. In patients with Type 2 diabetes and coronary heart disease, circulating levels of HMW adiponectin are selectively decreased due to an impaired secretion of this oligomer from adipocytes. The biosynthesis of the adiponectin oligomers is a complex process involving extensive post-translational modifications. Hydroxylation and glycosylation of several conserved lysine residues in the collagenous domain of adiponectin are necessary for the intracellular assembly and stabilization of its high-order oligomeric structures. Secretion of the adiponectin oligomers is tightly controlled by a pair of molecular chaperones in the ER (endoplasmic reticulum), including ERp44 (ER protein of 44 kDa) and Ero1-Lα (ER oxidoreductase 1-Lα). ERp44 inhibits the secretion of adiponectin oligomers through a thiol-mediated retention. In contrast, Ero1-Lα releases HMW adiponectin trapped by ERp44. The PPARγ (peroxisome-proliferator-activated receptor γ) agonists thiazolidinediones selectively enhance the secretion of HMW adiponectin through up-regulation of Ero1-Lα. In the present review, we discuss the recent advances in our understanding of the structural and biological properties of the adiponectin oligomeric isoforms and highlight the role of post-translational modifications in regulating the biosynthesis of HMW adiponectin.

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Liu, Guang-Hui, Jing Qu, Anne E. Carmack, Hyun Bae Kim, Chang Chen, Hongmei Ren, Andrew J. Morris, Brian N. Finck y Thurl E. Harris. "Lipin proteins form homo- and hetero-oligomers". Biochemical Journal 432, n.º 1 (25 de octubre de 2010): 65–76. http://dx.doi.org/10.1042/bj20100584.

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Lipin family members (lipin 1, 2 and 3) are bi-functional proteins that dephosphorylate PA (phosphatidic acid) to produce DAG (diacylglycerol) and act in the nucleus to regulate gene expression. Although other components of the triacylglycerol synthesis pathway can form oligomeric complexes, it is unknown whether lipin proteins also exist as oligomers. In the present study, using various approaches, we revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3. Both the N- and C-terminal regions of lipin 1 mediate its oligomerization in a head-to-head/tail-to-tail manner. We also show that lipin 1 subcellular localization can be influenced through oligomerization, and the individual lipin 1 monomers in the oligomer function independently in catalysing dephosphorylation of PA. The present study provides evidence that lipin proteins function as oligomeric complexes and that the three mammalian lipin isoforms can form combinatorial units.

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Prots, Iryna, Janina Grosch, Razvan-Marius Brazdis, Katrin Simmnacher, Vanesa Veber, Steven Havlicek, Christian Hannappel et al. "α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies". Proceedings of the National Academy of Sciences 115, n.º 30 (10 de julio de 2018): 7813–18. http://dx.doi.org/10.1073/pnas.1713129115.

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α-Synuclein (α-Syn) aggregation, proceeding from oligomers to fibrils, is one central hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are toxic by triggering neurodegenerative processes in in vitro and in vivo models. However, the precise contribution of α-Syn oligomers to neurite pathology in human neurons and the underlying mechanisms remain unclear. Here, we demonstrate the formation of oligomeric α-Syn intermediates and reduced axonal mitochondrial transport in human neurons derived from induced pluripotent stem cells (iPSC) from a Parkinson’s disease patient carrying an α-Syn gene duplication. We further show that increased levels of α-Syn oligomers disrupt axonal integrity in human neurons. We apply an α-Syn oligomerization model by expressing α-Syn oligomer-forming mutants (E46K and E57K) and wild-type α-Syn in human iPSC-derived neurons. Pronounced α-Syn oligomerization led to impaired anterograde axonal transport of mitochondria, which can be restored by the inhibition of α-Syn oligomer formation. Furthermore, α-Syn oligomers were associated with a subcellular relocation of transport-regulating proteins Miro1, KLC1, and Tau as well as reduced ATP levels, underlying axonal transport deficits. Consequently, reduced axonal density and structural synaptic degeneration were observed in human neurons in the presence of high levels of α-Syn oligomers. Together, increased dosage of α-Syn resulting in α-Syn oligomerization causes axonal transport disruption and energy deficits, leading to synapse loss in human neurons. This study identifies α-Syn oligomers as the critical species triggering early axonal dysfunction in synucleinopathies.

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Di Gennaro, Patrizia, Valentina Sabatini, Silvia Fallarini, Roberto Pagliarin y Guido Sello. "Polyphenol Polymerization by an Alternative Oxidative Microbial Enzyme and Characterization of the Biological Activity of Oligomers". BioMed Research International 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/3828627.

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The recombinant catalase-peroxidase HPI from E. coli was used as an alternative enzyme in polymerization reactions for the production of (−) epicatechin oligomers and their biological activity was characterized. The enzyme was prepared in two forms: a purified and an immobilized form. Both were tested for their activity in oxidative polymerization reactions, and their stability and reusability were assessed. The polymerization reactions were followed by SEC-HPLC analyses, and the substrate was completely converted into one or more polymerization products depending on the reactions conditions. Results showed that the utilized conditions allowed for the isolation of some oligomers of different molecular weight: the oligomers containing 6 and 7 units of epicatechin substrate are the heaviest ones. Epicatechin was also used in reactions catalyzed by HRP in the same reaction conditions for comparison. In addition, one selected oligomer obtained by HPI enzyme catalysis was shown to act as in vitro inhibitor of tumor cell growth, like one oligomer deriving from epicatechin by HRP catalysis. These data confirm that epicatechin oligomeric form is more effective than its monomer in biological activity and suggest the use of HPI as an alternative enzyme in reactions for the production of epicatechin oligomers.

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Bazaco, Raúl Blanco, José L. Segura y Carlos Seoane. "Recent advances in the design, synthesis and study of covalent conjugated oligomer–C60 ensembles". Collection of Czechoslovak Chemical Communications 74, n.º 6 (2009): 857–86. http://dx.doi.org/10.1135/cccc2008218.

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This review presents an overview of the most recent results in the field of conjugated oligomer covalently attached to the C60 sphere focusing mainly on donor–conjugated oligomer–C60 triads and conjugated oligomer–multifullerene materials. Well-defined monodisperse oligomers as new materials that exhibit interesting optoelectronic properties have been the subject of intense study during the last decade. In this regard, a huge amount of work has been devoted to the development of new synthetic strategies toward the synthesis of conjugated oligomeric materials with precise length and constitution and to their chemical functionalization in order to incorporate them into more complex molecular and supramolecular architectures. An important area of research in the field of conjugated oligomers involves the design and synthesis of donor–acceptor ensembles by combination of monodisperse π-conjugated oligomeric systems with C60 fullerene. Such hybrid systems have shown excited-state interactions making them excellent candidates for fundamental photophysical studies. In addition, these materials have found applications in the field of photovoltaic devices. A review with 70 references.

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Burford, Neil T., Tom Wehrman, Daniel Bassoni, Jonathan O’Connell, Martyn Banks, Litao Zhang y Andrew Alt. "Identification of Selective Agonists and Positive Allosteric Modulators for µ- and δ-Opioid Receptors from a Single High-Throughput Screen". Journal of Biomolecular Screening 19, n.º 9 (21 de julio de 2014): 1255–65. http://dx.doi.org/10.1177/1087057114542975.

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Hetero-oligomeric complexes of G protein–coupled receptors (GPCRs) may represent novel therapeutic targets exhibiting different pharmacology and tissue- or cell-specific site of action compared with receptor monomers or homo-oligomers. An ideal tool for validating this concept pharmacologically would be a hetero-oligomer selective ligand. We set out to develop and execute a 1536-well high-throughput screen of over 1 million compounds to detect potential hetero-oligomer selective ligands using a β-arrestin recruitment assay in U2OS cells coexpressing recombinant µ- and δ-opioid receptors. Hetero-oligomer selective ligands may bind to orthosteric or allosteric sites, and we might anticipate that the formation of hetero-oligomers may provide novel allosteric binding pockets for ligand binding. Therefore, our goal was to execute the screen in such a way as to identify positive allosteric modulators (PAMs) as well as agonists for µ, δ, and hetero-oligomeric receptors. While no hetero-oligomer selective ligands were identified (based on our selection criteria), this single screen did identify numerous µ- and δ-selective agonists and PAMs as well as nonselective agonists and PAMs. To our knowledge, these are the first µ- and δ-opioid receptor PAMs described in the literature.

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Renaud, Justin, Abdulhrahman M. Alhazmi y Paul M. Mayer. "Comparing the fragmentation chemistry of gas-phase adducts of poly(dimethylsiloxane) oligomers with metal and organic ions". Canadian Journal of Chemistry 87, n.º 2 (febrero de 2009): 453–59. http://dx.doi.org/10.1139/v08-184.

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Gas-phase ions of poly(dimethylsiloxane) oligomers were formed by electrospray ionization either by protonating them in solution with formic acid or by generating adducts of the oligomers with the metal ions Li+, Na+, K+, and Ag+ as well as with the organic cations NH4+, CH3CH2NH3+, and protonated glycine, aspartic acid, and 1,2-diphenylethylamine. The collision-induced fragmentation of the oligomeric ions was strongly dependent on the nature of the charging species. Ag+ adducts dissociated in a manner previously observed in secondary ion mass spectrometry experiments generating a series of linear and cyclic fragment ions, while Li+ adducts fragmented to form two ions: an adduct of the metal ion with the oligomer end-group and one with the remaining oligomer. Na+ and K+ adducts simply dissociate to form the bare metal ion. The organic species, to varying extents, transfer the proton to the oligomer to form a protonated poly(siloxane) ion. These protonated oligomers then dissociate at very low laboratory-frame collision energy along the siloxane backbone by loss of a silanol. These backbone fragments can then lose a methyl group to form a second series of fragment ions. Suggestions for probable mechanistic pathways for these processes are presented.

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Qing, Xiaoyu, Qian Wang, Hanyu Xu, Pei Liu y Luhua Lai. "Designing Cyclic-Constrained Peptides to Inhibit Human Phosphoglycerate Dehydrogenase". Molecules 28, n.º 17 (4 de septiembre de 2023): 6430. http://dx.doi.org/10.3390/molecules28176430.

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Although loop epitopes at protein-protein binding interfaces often play key roles in mediating oligomer formation and interaction specificity, their binding sites are underexplored as drug targets owing to their high flexibility, relatively few hot spots, and solvent accessibility. Prior attempts to develop molecules that mimic loop epitopes to disrupt protein oligomers have had limited success. In this study, we used structure-based approaches to design and optimize cyclic-constrained peptides based on loop epitopes at the human phosphoglycerate dehydrogenase (PHGDH) dimer interface, which is an obligate homo-dimer with activity strongly dependent on the oligomeric state. The experimental validations showed that these cyclic peptides inhibit PHGDH activity by directly binding to the dimer interface and disrupting the obligate homo-oligomer formation. Our results demonstrate that loop epitope derived cyclic peptides with rationally designed affinity-enhancing substitutions can modulate obligate protein homo-oligomers, which can be used to design peptide inhibitors for other seemingly intractable oligomeric proteins.

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Tesis sobre el tema "Oligomers"

Sun, Xiaohua. "Synthesis and properties of monodisperse oligomer-substituted calix[4]arene assemblies and related oligomers". HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/706.

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Cerf, Emilie. "Unraveling Alzheimer's disease: insight into the influence of apolipoprotein E isoforms on Abeta aggregation". Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209880.

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Nowadays, the emerging role of amyloid-β peptide (Aβ) oligomers in Alzheimer’s disease (AD) is widely accepted, putting aside the old idea that fibrils are the primary entities responsible for the onset of the disease. Recent studies indeed show that the level of soluble Aβ oligomeric forms better correlates with the progression of the disease than the level of fibrillar forms.

Using conditions which yield characteristic Aβ42 oligomers or fibrils, we studied the secondary structure of these species by ATR (attenuated total reflection)-FTIR (Fourier transform infrared) spectroscopy. Whereas fibrillar Aβ was organized in a parallel β-sheet conformation, oligomeric Aβ displayed distinct spectral features attributed to an antiparallel β-sheet structure. Antiparallel β-sheet structure may thus be a structural signature of oligomeric Aβ. Moreover, we noted striking spectral similarities between Aβ oligomers and a bacterial pore-forming protein, OmpF.

Apolipoprotein E (apoE) isoforms are strongly linked to Alzheimer’s disease, with the E4 isoform being the most recognized genetic risk factor so far. Nevertheless, the involvement of apoE4 in AD remains confusing. We evaluated the influence of apoE isoforms on Aβ aggregation in vitro. Comparing Aβ controls with Aβ incubated either with the apoE3 or apoE4 isoform, we observed a sharp reduction of the Aβ fibrillar content, whereas the oligomeric content was increased upon incubation with the pathological isoform apoE4. These data suggest that apoE4 binds and blocks Aβ in its oligomeric conformation, inhibiting further formation of less toxic fibrillar forms of Aβ. The enhanced interaction of apoE4 with Aβ oligomers could arise from its reported unique propensity to form a molten globule state, unlike the other isoforms of apoE. While previous studies mostly correlated E4 with fibrils, our data underline a correlation between apoE4 and Aβ oligomers. Our work reconciles apoE4 with the new amyloid cascade hypothesis and brings support to studies whose therapeutic strategy aims at designing inhibitors of the apoE/Aβ interaction./

Le rôle central des espèces oligomèriques du peptide amyloïde bêta (Aβ) dans la maladie d’Alzheimer est de plus en plus reconnu actuellement, mettant de côté l’ancien concept selon lequel les espèces fibrillaires sont les entités responsables du développement de la maladie. Des études récentes montrent en effet que le taux d’oligomères semble bien mieux corrélé à la progression de la maladie que le taux de fibrilles.

A l’aide de protocoles bien établis permettant de former des oligomères ou des fibrilles d’Aβ42 in vitro, nous avons étudié la structure secondaire de ces espèces par spectroscopie infrarouge en réflexion totale atténuée. Alors que les fibrilles présentaient une conformation en feuillets β parallèles, les oligomères quant à eux, ont révélé des caractéristiques spectrales distinctes, attribuées à du feuillet β antiparallèle. Cette structure en feuillets β antiparallèles pourrait donc représenter une signature structurale typique des espèces oligomèriques d’Aβ. De plus, nous avons observé de frappantes similarités spectrales entre les oligomères d’Aβ et une protéine bactérienne formant des pores, l’OmpF.

Les isoformes de l’apolipoprotéine E (apoE) sont fortement impliquées dans la maladie d’Alzheimer et plus particulièrement, l’isoforme E4 qui est actuellement reconnue comme étant le plus important facteur de risque d’origine génétique. Néanmoins, le rôle précis joué par l’apoE4 dans la maladie est encore mal connu. Nous avons étudié l’influence des isoformes de l’apoE sur l’agrégation du peptide amyloïde in vitro. En comparant des échantillons contrôle d’Aβ avec des échantillons incubés en présence d’apoE3 ou d’apoE4, nous avons observé une nette réduction de la quantité de fibrilles ainsi qu’une augmentation concomitante de la proportion d’oligomères lors de l’incubation avec l’isoforme pathologique E4. Ces résultats suggèrent que l’apoE4 interagit avec Aβ et le bloque dans sa conformation oligomèrique, inhibant ainsi le processus d’agrégation et la formation de fibrilles, espèces moins toxiques. Cette plus forte interaction entre l’apoE4 et les oligomères d’Aβ pourrait s’expliquer par la propriété unique de l’apoE4 à former un état intermédiaire ‘molten globule’, ce qui n’est pas le cas des autres isoformes. Tandis que d’anciennes études ont corrélé l’apoE4 principalement avec les fibrilles, nos résultats mettent en évidence un lien entre l’apoE4 et les oligomères d’Aβ, respectivement l’isoforme pathologique et les espèces les plus toxiques du peptide. Ce travail réconcilie donc l’apoE4 avec la nouvelle hypothèse de la « cascade amyloïde » et soutient les études thérapeutiques visant à mettre au point des inhibiteurs spécifiques de l’interaction apoE/Aβ.

Doctorat en Sciences agronomiques et ingénierie biologique
info:eu-repo/semantics/nonPublished

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Lederer, Kay. "Crystalline assemblies of folded oligomers". [S.l. : s.n.], 1999. http://ArchiMeD.uni-mainz.de/pub/2000/0036/diss.pdf.

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Anderson, Sally. "Templated synthesis of porphyrin oligomers". Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/251546.

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Forrest, Martin J. "Characterisation of vinyl chloride oligomers". Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/27931.

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A low molecular weight fraction was obtained from a mass polymerised PVC resin by using diethyl ether Soxhlet extraction followed by either preparative gel filtration or solvent fractionation. A gas chromatography - mass spectroscopy (GC-MS) analysis of this fraction revealed that, in addition to vinyl chloride (VC) oligomers, it contained a large number of other compounds, in particular a large concentration of phthalates. By using adsorption liquid chromatography it was possible to remove the phthalates, along with other contaminants having a similar or greater polarity, from the low molecular weight PVC fraction.

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Szczypiński, Filip Tomasz. "Ester-based synthetic information oligomers". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289396.

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Wahl, Markus C. "Crystal Structures of RNA Oligomers /". The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487933245536475.

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Doss, Raymond Michael Stoltz Brian M. Dervan Peter B. "Programmable oligomers for DNA recognition /". Diss., Pasadena, Calif. : California Institute of Technology, 2006. http://resolver.caltech.edu/CaltechETD:etd-09202008-110622.

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Stross, Alexander. "Synthetic H-bonding information oligomers". Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12365/.

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The nucleic acids contain chemical information in the form of a sequence of bases. This information content is expressed through sequence selective duplex formation and template directed synthesis. To date, the only programmable artificial information molecules that can truly rival the nucleic acids, in terms of their function, are structurally very similar to the nucleic acids. This thesis describes a synthetic approach to duplex forming hydrogen bonding oligomers that contain information in the form of a sequence of H-bond donor and acceptor groups, in the pursuit of a programmable material that is orthogonal to the nucleic acids. Chapter 1 is a literature review of natural and synthetic information molecules and their applications in nanotechnology, including an overview of the structurally reengineered versions of the nucleic acids, foldamers, template polymerisation and synthetic duplexes. The review highlights the absence of totally synthetic information oligomers, that are orthogonal to the nucleic acids, and Chapter 2 sets out the aims of this thesis, which is to address this gap. Chapter 3 describes the synthesis of oligomers equipped with phenol H-bond donors and phosphine oxide H-bond acceptors. Through cooperative H-bond formation, these oligomers form double stranded complexes, which were characterised by NMR titrations and thermal denaturation experiments. For each additional H-bond there is an order of magnitude increase in association constant. In Chapter 4 it is demonstrated that the modular design for the oligomers in Chapter 3 represents a general strategy to synthetic information oligomers. Two new classes of H-bond acceptor oligomer were synthesised, bearing pyridine and pyridine N-oxide groups. Both these systems also exhibit cooperative duplex formation with H-bond donor oligomers, which were characterised by NMR titration. Chapter 5 examines the ability of mixed sequence 3-mers formed of H-bond donors (phenol) and H-bond acceptors (pyridine N-oxide) to form duplexes in a sequence selective manner. All 8 combinations of donor and acceptor were synthesised, and NMR titrations were used to measure the association constants for each pairwise combination of oligomers. Sequence matched duplexes generally have the highest association constants, but there are some anomalies.

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Deloule, Vivien. "Study on extraction and characterization of softwoods hemicelluloses oligomers and their influence on gut microbiota". Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAI107.

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Libros sobre el tema "Oligomers"

Uglea, Constantin V. Synthesis and characterization of oligomers. Boca Raton, Fla: CRC Press, 1991.

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Uglea, Constantin V. Liquid chromatography of oligomers. New York: M. Dekker, 1996.

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Moulton, Hong M. y Jon D. Moulton, eds. Morpholino Oligomers. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6.

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Harris, Frank W. y Harry J. Spinelli, eds. Reactive Oligomers. Washington, D.C.: American Chemical Society, 1985. http://dx.doi.org/10.1021/bk-1985-0282.

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1942-, Harris Frank Wayne, Spinelli Harry J. 1949-, American Chemical Society. Division of Polymer Chemistry., American Chemical Society. Division of Polymeric Materials: Science and Engineering. y American Chemical Society Meeting, eds. Reactive oligomers. Washington, D.C: American Chemical Society, 1985.

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Ėntelis, S. G. Reactive oligomers. Utrecht, The Netherlands: VSP, 1989.

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A, Shagini͡an Sh y Institut khimicheskoĭ fiziki im. N.N. Semenova, eds. Spinodalʹnyĭ raspad binarnykh smeseĭ oligomerov v uslovii͡akh khimicheskoĭ reakt͡sii. Moskva: Tip. IKhFCh RAN, 1994.

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Francqui, Colloquium (4th 1998 Brussels Belgium). Conjugated oligomers, polymers, and dendrimers: From polyacetylene to DNA : proceedings of the Fourth Francqui Colloqium, 21-23 October 1998, Brussels. Paris: De Boeck Université, 1999.

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Mezhikovskiĭ, S. M. Fizikokhimii͡a︡ reakt͡s︡ionnosposobnykh oligomerov: Termodinamika, kinetika, struktura. Moskva: Nauka, 1998.

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A, Krent͡s︡elʹ B., Borisova, N. A., kandidat khimicheskikh nauk. y Institut neftekhimicheskogo sinteza im. A.V. Topchieva., eds. Oligomerizat͡s︡ii͡a︡ nepredelʹnykh uglevodorodov. Moskva: Akademii͡a︡ nauk SSSR, In-t neftekhimicheskogo sinteza im. A.V. Topchieva, 1987.

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Capítulos de libros sobre el tema "Oligomers"

Summerton, James E. "Invention and Early History of Morpholinos: From Pipe Dream to Practical Products". En Morpholino Oligomers, 1–15. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_1.

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Daly, Seth M., Carolyn R. Sturge y David E. Greenberg. "Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers". En Morpholino Oligomers, 115–22. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_10.

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Krtková, Jana y Alexander R. Paredez. "Use of Translation Blocking Morpholinos for Gene Knockdown in Giardia lamblia". En Morpholino Oligomers, 123–40. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_11.

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Gong, Qiuming y Zhengfeng Zhou. "Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos". En Morpholino Oligomers, 141–50. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_12.

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Crossley, Madzia P. y Torsten Krude. "Targeting Functional Noncoding RNAs". En Morpholino Oligomers, 151–60. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_13.

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Liu, Guozheng. "Use of Morpholino Oligomers for Pretargeting". En Morpholino Oligomers, 161–79. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_14.

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Levicky, Rastislav, Ursula Koniges y Napoleon Tercero. "Diagnostic Applications of Morpholinos and Label-Free Electrochemical Detection of Nucleic Acids". En Morpholino Oligomers, 181–90. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_15.

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Rajsbaum, Ricardo. "Intranasal Delivery of Peptide-Morpholinos to Knockdown Influenza Host Factors in Mice". En Morpholino Oligomers, 191–99. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_16.

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Maruyama, Rika, Yusuke Echigoya, Oana Caluseriu, Yoshitsugu Aoki, Shin’ichi Takeda y Toshifumi Yokota. "Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy". En Morpholino Oligomers, 201–13. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_17.

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Karunakaran, Devi Krishna Priya y Rahul Kanadia. "In Vivo and Explant Electroporation of Morpholinos in the Developing Mouse Retina". En Morpholino Oligomers, 215–27. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6817-6_18.

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Actas de conferencias sobre el tema "Oligomers"

Shutikov, A. A., G. M. Arzumanyan, K. Z. Mamatkulov, E. Arynbek y D. S. Zakrytnaya. "ANALYSIS OF THE SECONDARY STRUCTURE OF AΒ (1-42) PEPTIDE IN THE AMIDE I REGION BY RAMAN SPECTROSCOPY". En X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-220.

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Resumen

Amyloid fibrils found in plaques in Alzheimer’s disease (AD) brains are composed of amyloid-β peptides. Aβ peptides are formed from the transmembrane amyloid precursor protein (APP). They have pronounced fibrillogenic properties, and its oligomers are toxic to nerve cells, causing their degeneration and death. Oligomeric amyloid-β (1-42) is thought to play a critical role in neurodegeneration in AD. In this work, we analyzed the conformational transformation of Aβ (1-42) peptides embedded in membrane mimetics by Raman spectroscopy. The main goal of the scientific study was to investigate the structural changes of the peptide leading to the formation of amyloid oligomers and fibrils.

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Hentschel, Mario, Martin Schäferling, Thomas Weiss, Hans-Georg Kuball, Na Liu y Harald W. Giessen. "Three-dimensional Chiral Plasmonic Oligomers". En Quantum Electronics and Laser Science Conference. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/qels.2012.qth4f.1.

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Kim, Y. H., F. Li y H. Zimmer. "Charged states of thiophene oligomers". En International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.834786.

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Ozols, Andris O., Valdis Kampars, Mara Reinfelde y Valdis Kokars. "Hologram recording in azobenzene oligomers". En SPIE Proceedings, editado por Janis Spigulis, Janis Teteris, Maris Ozolinsh y Andrejs Lusis. SPIE, 2003. http://dx.doi.org/10.1117/12.517010.

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Ding, Y., S. Garland, M. Howland, A. Revzin y T. Pan. "Universal nano-adhesive of PDMS oligomers". En 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2012. http://dx.doi.org/10.1109/memsys.2012.6170210.

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Weber, Thorsten, Felix von Cube, Stephan Irsen y Stefan Linden. "Near-field Study of Plasmonic Oligomers". En Quantum Electronics and Laser Science Conference. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/qels.2012.qw1b.2.

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Kroychuk, M. K., E. V. Melik-Gaykazyan, A. S. Shorokhov, D. Y. Choi, V. V. Zubyuk, T. V. Dolgova, M. R. Shcherbakov, D. N. Neshev, A. A. Fedyanin y Y. S. Kivshar. "Nonlinear anisotropy in silicon nanoparticle oligomers". En ADVANCES IN ELECTRICAL AND ELECTRONIC ENGINEERING: FROM THEORY TO APPLICATIONS: Proceedings of the International Conference on Electrical and Electronic Engineering (IC3E 2017). Author(s), 2017. http://dx.doi.org/10.1063/1.4998096.

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Fritsch, V. y E. Westhof. "Molecular Dynamics Simulations of DNA Oligomers". En Advances in biomolecular simulations. AIP, 1991. http://dx.doi.org/10.1063/1.41351.

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Poplawski, J., E. Ehrenfreund, R. Pugh, M. Ibrahim, A. J. Frank, J. Cornil y J. L. Bredas. "Photogeneration of polarons in sexithiophene oligomers". En International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.834699.

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Milicchio, Franco y Mattia C. F. Prosperi. "HErCoOl: High-Throughput Error Correction by Oligomers". En 2014 IEEE 27th International Symposium on Computer-Based Medical Systems (CBMS). IEEE, 2014. http://dx.doi.org/10.1109/cbms.2014.7.

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Informes sobre el tema "Oligomers"

Good, J. R. y Aileen Huang-Saad. Nucleotide Oligomers. Fort Belvoir, VA: Defense Technical Information Center, enero de 2001. http://dx.doi.org/10.21236/ada407868.

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Hnatowich, DJ. Targeting Cancer with Antisense Oligomers. Office of Scientific and Technical Information (OSTI), octubre de 2008. http://dx.doi.org/10.2172/940005.

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Rajca, Andrzej. Polymers and Oligomers of Carbon-Sulfur Helicenes. Fort Belvoir, VA: Defense Technical Information Center, marzo de 2004. http://dx.doi.org/10.21236/ada421423.

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Reynolds, John R. Electroactive Reactive Oligomers and Polymers as Device Components. Fort Belvoir, VA: Defense Technical Information Center, febrero de 2009. http://dx.doi.org/10.21236/ada510609.

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Peterson, Rebecca A. Antagonistic Action of Hyaluronan Oligomers in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 1998. http://dx.doi.org/10.21236/ada377165.

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Toole, Bryan P. y Jeanine Ward. Antagonistic Action of Hyaluronan Oligomers in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 1999. http://dx.doi.org/10.21236/ada381536.

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Robert Perry, Teresa Grocela-Rocha, Michael O'Brien, Sarah Genovese, Benjamin Wood, Larry Lewis, Hubert Lam, Malgorzata Rubinsztajn, Grigorii Soleveichik y Sergei Kniajanski. Novel High Capacity Oligomers for Low Cost CO2 Capture. Office of Scientific and Technical Information (OSTI), septiembre de 2010. http://dx.doi.org/10.2172/1013258.

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Baker, Kenneth N. y Albert V. Fratini. Crystal Structures of Poly-Paraphenylene Oligomers Containing Pendant Phenyl Groups. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 1989. http://dx.doi.org/10.21236/ada218158.

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Koberstein, Jeffrey T. Molecular Engineering of Thin Polymer Films Prepared from Functionally-Terminated Oligomers. Fort Belvoir, VA: Defense Technical Information Center, febrero de 1995. http://dx.doi.org/10.21236/ada291681.

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Garcia, A. E. y G. Hummer. Theoretical studies of the interaction of water with DNA oligomers and proteins. Office of Scientific and Technical Information (OSTI), abril de 1996. http://dx.doi.org/10.2172/212500.

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