Artículos de revistas sobre el tema "Non thermal plasma (NTP)"
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1
Olovyannikova, R. Ya, Т. A. Makarenko, E. V. Lychkovskaya, E. S. Gudkova, G. A. Muradyan, N. N. Medvedeva, Т. N. Chekisheva et al. "Chemical mechanisms of non-thermal plasma action on cells". Fundamental and Clinical Medicine 5, n.º 4 (25 de diciembre de 2020): 104–16. http://dx.doi.org/10.23946/2500-0764-2020-5-4-104-115.
Resumen
Non-thermal plasma (NTP) in the air around the cell layer or biological tissues is considered as a generator of reactive oxygen and nitrogen species, ions, and solvated/aquated electrons. This review covers current understanding on the effects of NTP in living systems, with the focus on the role of free radicals and other NTP-generated particles in the chemical modification of biomacromolecules and regulation of signal transduction. We summarise recent data on the impact of NTP-originated products on intracellular redox balance, mitochondrial biogenesis, cell membranes and organelles. In addition, we discuss the transport of NTP products across the biological membranes. Since the expression of numerous transporter systems differs at various stages of development, distinct cell lines, and in pathological conditions, experiments on NTP effects should be designed in various models for the assessment of cell- and tissue-specific response. Notably, NTP effects are observed throughout the whole tissue even when particles are generated at the surface. Special attention is paid to the NTP-treated solutions (phosphate buffered saline, Ringer’s solution, cell culture medium) as their composition and pH can be significantly altered. However, these data also suggest novel opportunities for the application of NTP and NTP-treated solutions in biomedicine. Studies on the mechanisms of NTP action on biological systems should contain analysis of events coupled to generation and accumulation of reactive oxygen and nitrogen species, neutral compounds, solvated electrons, and detection of new cellular targets of their action. This would allow developing of efficient and safe protocols for NTP applications in biology and medicine.
2
Veerana, Mayura, Nannan Yu, Wirinthip Ketya y Gyungsoon Park. "Application of Non-Thermal Plasma to Fungal Resources". Journal of Fungi 8, n.º 2 (21 de enero de 2022): 102. http://dx.doi.org/10.3390/jof8020102.
Resumen
In addition to being key pathogens in plants, animals, and humans, fungi are also valuable resources in agriculture, food, medicine, industry, and the environment. The elimination of pathogenic fungi and the functional enhancement of beneficial fungi have been the major topics investigated by researchers. Non-thermal plasma (NTP) is a potential tool to inactivate pathogenic and food-spoiling fungi and functionally enhance beneficial fungi. In this review, we summarize and discuss research performed over the last decade on the use of NTP to treat both harmful and beneficial yeast- and filamentous-type fungi. NTP can efficiently inactivate fungal spores and eliminate fungal contaminants from seeds, fresh agricultural produce, food, and human skin. Studies have also demonstrated that NTP can improve the production of valuable enzymes and metabolites in fungi. Further studies are still needed to establish NTP as a method that can be used as an alternative to the conventional methods of fungal inactivation and activation.
3
Tanaka, Hiromasa, Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa y Masaru Hori. "Molecular mechanisms of non-thermal plasma-induced effects in cancer cells". Biological Chemistry 400, n.º 1 (19 de diciembre de 2018): 87–91. http://dx.doi.org/10.1515/hsz-2018-0199.
Resumen
AbstractPlasma is the fourth state of matter with higher energy than gas; non-thermal plasma (NTP) is currently available. As NTP is useful in sterilization, promoting wound healing and cancer treatments, the molecular mechanisms of plasma-induced effects in living cells and microorganisms are of significant interest in plasma medicine with medical-engineering collaboration. Molecular mechanisms of plasma-induced effects in cancer cells will be described in this minireview. Both direct and indirect methods to treat cancer cells with NTP have been developed. NTP interacts directly with not only cancer cells but also the liquids surrounding cancer cells and the immune cells that target them. Reactive oxygen and nitrogen species play key roles in NTP-induced effects; however, other mechanisms have been suggested. The complex interactions between NTP, cells and liquids have been extensively studied. In the future, details regarding NTP-induced effects on gene regulatory networks, signaling networks, and metabolic networks will be elucidated.
4
Gholami, Rahman, Cristina E. Stere, Alexandre Goguet y Christopher Hardacre. "Non-thermal-plasma-activated de-NO x catalysis". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376, n.º 2110 (27 de noviembre de 2017): 20170054. http://dx.doi.org/10.1098/rsta.2017.0054.
Resumen
The combination of non-thermal plasma (NTP) with catalyst systems as an alternative technology to remove NO x emissions in the exhaust of lean-burn stationary and mobile sources is reviewed. Several factors, such as low exhaust gas temperatures (below 300°C), low selectivity to N 2 and the presence of impurities, make current thermally activated technologies inefficient. Various hybrid plasma–catalyst systems have been examined and shown to have a synergistic effect on de-NO x efficiency when compared with NTP or catalyst-alone systems. The NTP is believed to form oxygenated species, such as aldehydes and nitrogen-containing organic species, and to convert NO to NO 2 , which improves the reduction efficiency of N 2 during hydrocarbon-selective catalytic reduction reactions. The NTP has been used as a pretreatment to convert NO to its higher oxidation states such as NO 2 to improve NO x reduction efficiency in the subsequent processes, e.g. NH 3 -selective catalytic reduction. It has been applied to the lean phase of the NO x storage to improve the adsorption capacity of the catalyst by conversion of NO to NO 2 . Alternatively, a catalyst with high adsorption capacity is chosen and the NTP is applied to the rich phase to improve the reduction activity of the catalyst at low temperature. This article is part of a discussion meeting issue ‘Providing sustainable catalytic solutions for a rapidly changing world’.
5
Tuhvatulin, A. I., E. V. Sysolyatina, D. V. Scheblyakov, D. Yu Logunov, M. M. Vasiliev, M. A. Yurova, M. A. Danilova et al. "Non-Thermal Plasma Causes P53-Dependent Apoptosis in Human Colon Carcinoma Cells". Acta Naturae 4, n.º 3 (15 de septiembre de 2012): 82–87. http://dx.doi.org/10.32607/20758251-2012-4-3-82-87.
Resumen
Non-thermal plasma (NTP) consists of a huge amount of biologically active particles, whereas its temperature is close to ambient. This combination allows one to use NTP as a perspective tool for solving different biomedical tasks, including antitumor therapy. The treatment of tumor cells with NTP caused dose-dependent effects, such as growth arrest and apoptosis. However, while the outcome of NTP treatment has been established, the molecular mechanisms of the interaction between NTP and eukaryotic cells have not been thoroughly studied thus far. In this work, the mechanisms and the type of death of human colon carcinoma HCT 116 cells upon application of non-thermal argon plasma were studied. The effect of NTP on the major stress-activated protein p53 was investigated. The results demonstrate that the viability of HCT116 cells upon plasma treatment is dependent on the functional p53 protein. NTP treatment caused an increase in the intracellular concentration of p53 and the induction of the p53-controlled regulon. The p53-dependent accumulation of active proapoptotic caspase-3 was shown in NTP-treated cells. The study was the first to demonstrate that treatment of human colon carcinoma cells with NTP results in p53-dependent apoptosis. The results obtained contribute to our understanding of the applicability of NTP in antitumor therapy.
6
Holubová, Ľudmila, Stanislav Kyzek, Ivana Ďurovcová, Jana Fabová, Eva Horváthová, Andrea Ševčovičová y Eliška Gálová. "Non-Thermal Plasma—A New Green Priming Agent for Plants?" International Journal of Molecular Sciences 21, n.º 24 (12 de diciembre de 2020): 9466. http://dx.doi.org/10.3390/ijms21249466.
Resumen
Since the earliest agricultural attempts, humankind has been trying to improve crop quality and yields, as well as protect them from adverse conditions. Strategies to meet these goals include breeding, the use of fertilisers, and the genetic manipulation of crops, but also an interesting phenomenon called priming or adaptive response. Priming is based on an application of mild stress to prime a plant for another, mostly stronger stress. There are many priming techniques, such as osmopriming, halopriming, or using physical agents. Non-thermal plasma (NTP) represents a physical agent that contains a mixture of charged, neutral, and radical (mostly reactive oxygen and nitrogen species) particles, and can cause oxidative stress or even the death of cells or organisms upon interaction. However, under certain conditions, NTP can have the opposite effect, which has been previously documented for many plant species. Seed surface sterilization and growth enhancement are the most-reported positive effects of NTP on plants. Moreover, some studies suggest the role of NTP as a promising priming agent. This review deals with the effects of NTP treatment on plants from interaction with seed and cell surface, influence on cellular molecular processes, up to the adaptive response caused by NTP.
7
Le Bras, Florian, Gaëlle Carré, Yasmina Aguemon, Marius Colin y Marie-Paule Gellé. "Inactivation of Enveloped Bovine Viral Diarrhea Virus and Non-Enveloped Porcine Parvovirus Using Low-Pressure Non-Thermal Plasma". Life 11, n.º 12 (24 de noviembre de 2021): 1292. http://dx.doi.org/10.3390/life11121292.
Resumen
As the worldwide population has been experiencing since 2020, viruses represent a serious threat to global well-being. To avoid viral transmission through surgery or medical examination, sterilization of medical material is needed. From emerging sterilization processes, the use of non-thermal plasma (NTP) arises as a promising technique to efficiently reduce microbial burden on medical devices, including new complex polymers as thermosensitive ones. Thus, we evaluated the antiviral efficacy of a low-pressure NTP process taking place in a sealed bag. For this purpose, two different plasmas, O2 100% plasma and Ar 80%–O2 20% plasma, were tested against two viruses: the bovine viral diarrhea virus and the porcine parvovirus, surrogates of human hepatitis C virus and human parvovirus B19, respectively. The efficacy of both NTP treatments on viral load can be detected after only five minutes. Moreover, the longer the NTP treatments last, the more the load decreases. The most effective load reduction was obtained with a 120-min O2 plasma treatment inducing a minimum of four-log viral load reduction. So, this process demonstrated strong virucidal capacity inside a sealed bag and represents a very interesting opportunity in the field of fragile medical devices sterilization or disinfection.
8
Adnan, Zulfam, Sadullah Mir y Mudassar Habib. "Exhaust gases depletion using non-thermal plasma (NTP)". Atmospheric Pollution Research 8, n.º 2 (marzo de 2017): 338–43. http://dx.doi.org/10.1016/j.apr.2016.10.005.
9
Scholtz, Vladimír, Jana Jirešová, Božena Šerá y Jaroslav Julák. "A Review of Microbial Decontamination of Cereals by Non-Thermal Plasma". Foods 10, n.º 12 (26 de noviembre de 2021): 2927. http://dx.doi.org/10.3390/foods10122927.
Resumen
Cereals, an important food for humans and animals, may carry microbial contamination undesirable to the consumer or to the next generation of plants. Currently, non-thermal plasma (NTP) is often considered a new and safe microbicidal agent without or with very low adverse side effects. NTP is a partially or fully ionized gas at room temperature, typically generated by various electric discharges and rich in reactive particles. This review summarizes the effects of NTP on various types of cereals and products. NTP has undisputed beneficial effects with high potential for future practical use in decontamination and disinfection.
10
Moszczyńska, Julia, Katarzyna Roszek y Marek Wiśniewski. "Non-Thermal Plasma Application in Medicine—Focus on Reactive Species Involvement". International Journal of Molecular Sciences 24, n.º 16 (11 de agosto de 2023): 12667. http://dx.doi.org/10.3390/ijms241612667.
Resumen
Non-thermal plasma (NTP) application in medicine is a dynamically developing interdisciplinary field. Despite the fact that basics of the plasma phenomenon have been known since the 19th century, growing scientific attention has been paid in recent years to the use of plasma in medicine. Three most important plasma-based effects are pivotal for medical applications: (i) inactivation of a broad spectrum of microorganisms, (ii) stimulation of cell proliferation and angiogenesis with lower plasma treatment intensity, and (iii) inactivation of cells by initialization of cell death with higher plasma intensity. In this review, we explain the underlying chemical processes and reactive species involvement during NTP in human (or animal) tissues, as well as in bacteria inactivation, which leads to sterilization and indirectly supports wound healing. In addition, plasma-mediated modifications of medical surfaces, such as surgical instruments or implants, are described. This review focuses on the existing knowledge on NTP-based in vitro and in vivo studies and highlights potential opportunities for the development of novel therapeutic methods. A full understanding of the NTP mechanisms of action is urgently needed for the further development of modern plasma-based medicine.
11
Lux, Jaroslav, Radim Dobiáš, Ivana Kuklová, Radek Litvik, Vladimír Scholtz, Hana Soušková, Josef Khun et al. "Inactivation of Dermatophytes Causing Onychomycosis and Its Therapy Using Non-Thermal Plasma". Journal of Fungi 6, n.º 4 (10 de octubre de 2020): 214. http://dx.doi.org/10.3390/jof6040214.
Resumen
Onychomycosis is one of the most common nail disorders. Its current treatment is not satisfactorily effective and often causes adverse side effects. This study aims to determine the optimal conditions for non-thermal plasma (NTP) inactivation of the most common dermatophytes in vitro and to apply it in patient`s therapy. The in vitro exposure to NTP produced by negative DC corona discharge caused full inactivation of Trichophyton spp. if applied during the early growth phases. This effect decreased to negligible inactivation with the exposure applied six days after inoculation. In a group of 40 patients with onychomycosis, NTP therapy was combined with nail plate abrasion and refreshment (NPAR) or treatment with antimycotics. The cohort included 17 patients treated with NPAR combined with NTP, 11 patients treated with antimycotics and NTP, and 12 patients treated with NPAR alone. The combination of NPAR and NTP resulted in clinical cure in more than 70% of patients. The synergistic effect of NPAR and NTP caused 85.7% improvement of mycological cure confirmed by negative microscopy and culture of the affected nail plate. We conclude that NTP can significantly improve the treatment of onychomycosis.
12
Vaiano, Vincenzo y Giuseppina Iervolino. "Non-Thermal Plasma-Assisted Catalytic Reactions for Environmental Protection". Catalysts 11, n.º 4 (18 de abril de 2021): 509. http://dx.doi.org/10.3390/catal11040509.
13
Sysolyatina, E., A. Petryakov, M. Abdulkadieva, E. Vasilieva, M. Chernukha, L. Avetisyan, T. Alekseeva et al. "Use of non-thermal plasma for decontamination of titanium implants". Journal of Physics: Conference Series 2270, n.º 1 (1 de mayo de 2022): 012045. http://dx.doi.org/10.1088/1742-6596/2270/1/012045.
Resumen
Abstract Non-thermal plasma (NTP) has a non-specific bactericidal effect as a result of the synergistic activity of biologically active components contained in the plasma torch. As part of this work, we investigated the potential of using NTP for the antibacterial treatment of titanium implants. Applying samples made of the VT6 titanium alloy used to create implants and a strain of antibiotic-resistant staphylococcus MRSA, we showed that 1) plasma pretreatment of the sample surface led to the formation of a film containing titanium oxides which have a weak bactericidal effect reducing the colonization of the surface with staphylococcus; 2) direct plasma treatment of a polished titanium disk for 120 seconds reduced the contamination of S. aureus by 563 times; 3) the relief of the titanium surface itself plays an important role in the effectiveness of decontamination: the bacteria on the rough surface were less susceptible to the effects of NTP than the bacteria on the polished surface. In total, the data obtained indicate the need to continue research aimed at increasing the effectiveness of the bactericidal activity of NTP against bacteria on the surface of titanium implants.
14
Rodríguez-Méndez, Benjamín G., Régulo López-Callejas, Antonio Mercado-Cabrera, Rosendo Peña-Eguiluz, Raúl Valencia-Alvarado, Mario Betancourt-Ángeles, Guillermo Berrones-Stringel y César Jaramillo-Martínez. "Harnessing Non-Thermal Plasma to Supercharge Recovery in Abdominal Surgeries: A Pilot Study". Journal of Clinical Medicine 13, n.º 2 (11 de enero de 2024): 408. http://dx.doi.org/10.3390/jcm13020408.
Resumen
(1) Background: This study aims to evaluate the efficacy and safety of non-thermal plasma (NTP) therapy in accelerating wound healing in patients who have undergone laparoscopic and open surgeries. (2) Methods: NTP was applied using a needle-type reactor with an irradiance of 0.5 W/cm2 on the surgical wounds of fifty patients after obtaining informed consent. Three NTP treatments, each lasting three minutes, were administered hourly. (3) Results: The pilot study showed that NTP-treated surgical wounds healed completely without any signs of infection, dehiscence, pain, or itching. Notably, patients reported minimal pain after the NTP treatment. Visual assessments conducted twenty-four hours after surgery revealed no redness or fluid discharge. Comparisons with traditionally sutured wounds indicated that NTP-treated wounds healed at a rate equivalent to seven days. (4) Conclusions: The application of NTP in laparoscopic and open wounds proved safe and effective, expediting the wound healing process and eliminating clinical risks post-surgery. Significantly, NTP facilitated a healing rate within twenty-four hours, equivalent to seven days for suture-treated wounds, significantly reducing the hospitalization time to a single day. These findings highlight the potential of NTP to be a transformative approach for promoting postoperative recovery.
15
Arisawa, Emilia Angela Lo Schiavo, Juliana Cunha Cardoso, Lucia Vieira y Rauirys Alencarde de Oliveira. "Non-thermal plasma applied to treating diabetic foot". Research, Society and Development 10, n.º 12 (30 de septiembre de 2021): e539101220128. http://dx.doi.org/10.33448/rsd-v10i12.20128.
Resumen
Objective: Evaluate the effects of non-thermal plasma therapy (NTP) for the treatment of diabetic foot injuries in two patients, considering the evolution of the steps of the healing process, pain sensitivity, and quality of life. Methodology: Lesions in the lower limbs of two patients with Diabetes mellitus (DM) with similar anatomical location and dimensions were treated, one patient with controlled DM and the other classified as uncontrolled DM. The application of NTP was performed for 10 minutes, 3 times a week in direct contact with the lesions. The same protocol was applied in both clinical cases to allow a reliable evaluation of the healing process. Results and Discussion: The lesions presented progressive regression until their complete regeneration (100%), without the development of infections during treatment. Conclusion: The results obtained in the two clinical cases allow us to attest that the NTP application in the treatment of diabetic foot injuries resulting from DM constituted an important therapeutic tool for the evolution of the healing process of these injuries, with a significant reduction in the lesion area in a short period of time. The definition of the ideal treatment protocol depends on the expansion of the number of studies and the increase of the studied population.
16
Cai, Yi Xi, Li Li Lei y Pan Wang. "The Effect of Specific Input Energy on Promotion of NO–NO2 of Diesel Engine with Non-Thermal Plasma Technology". Advanced Materials Research 204-210 (febrero de 2011): 955–59. http://dx.doi.org/10.4028/www.scientific.net/amr.204-210.955.
Resumen
The removal of diesel exhausts by non-thermal plasma technology has been investigated focused on the simulation gas experiment at atmospheric pressure and room temperature for many years. However, the research for real diesel engine is need to be further studied. In the experiments, a non-thermal plasma (NTP) reactor was designed based upon dielectric barrier discharge. NO/NO2 conversion was studied as a function of the specific input energy (SIE) by varying the frequency and voltage applied on the NTP reactor through bench test. Results showed that NTP SIE was increased with the voltage at each frequency. The conversion of NO to NO2 was increased at higher NTP SIE. However, NO will further be converted to other active species but not only NO2.
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Sutter, Julia, Jascha Brettschneider, Sara Mamchur, Fred Krebs, Sophia Gershman y Vandana Miller. "Inclusion of Biological Targets in the Analysis of Electrical Characteristics of Non-Thermal Plasma Discharge". Plasma 6, n.º 3 (15 de septiembre de 2023): 577–91. http://dx.doi.org/10.3390/plasma6030040.
Resumen
In Plasma Medicine studies, the effect of non-thermal plasma (NTP) on biological targets is typically correlated with the amount of stable reactive oxygen and nitrogen species produced in a liquid medium. The effect of NTP and the response of the biological target on cellular redox mechanisms is overlooked in these investigations. Additionally, the influence of electrical properties of cells on the physical properties of NTP is neglected. Therefore, we used a floating electrode dielectric barrier discharge plasma to explore the impact of cell structure, size, and viability of the biological target on the physical properties of NTP. Lissajous figures were used to determine circuit capacitance and energy per cycle during NTP exposure of different cell suspensions. We show that both, structural integrity and active enzymic processes of cells change the electrical properties of NTP. Correlations were also drawn between NTP-produced hydrogen peroxide and nitrite with measured capacitance. Our studies indicate that the observed changes between different cell suspensions may be due to a feedback loop between the biological target and the NTP source. In future studies, a more detailed analysis is needed to improve the control of clinical NTP devices.
18
Kim, Hee-Jun, Chan-Hee Won y Hyun-Woo Kim. "Optimized Pretreatment of Non-Thermal Plasma for Advanced Sewage Oxidation". International Journal of Environmental Research and Public Health 17, n.º 20 (21 de octubre de 2020): 7694. http://dx.doi.org/10.3390/ijerph17207694.
Resumen
This study investigates how the non-thermal plasma (NTP) process leads to advanced oxidation of sewage using response surface methodology. For environmentally viable and efficient operation of the NTP process, temperature and contact time were selected as two important independent variables. Their impacts on the performance were tested following an experimental design to figure out optimal operating conditions. Based on obtained treatment efficiency, statistically optimized conditions were derived by using an approach adapting the central composite design. Results show that coupling 40 °C of temperature and 4 h of contact time demonstrate optimal performance for total chemical oxygen demand (TCOD, 59%) and total suspended solids (85%), respectively. This implies that NTP may present efficient particulate destruction leading to organic solids dissolution. Statistical analysis reveals that the contact time shows more significant dependency than the temperature on the advanced oxidation of TCOD, possibly due to dissolved organic material. For total nitrogen removal, on the contrary, the optimal efficiency was strongly related to the higher temperature (~68 °C). This work provides an inroad to considering how NTP can optimally contribute to better oxidation of multiple pollutants.
19
Lee, Sung-Tak, Yoon-Seo Jang, Uk-Kyu Kim, Hyung-Joon Kim, Mi-Heon Ryu, Gyoo-Cheon Kim y Dae-Seok Hwang. "Non-thermal plasma application enhances the recovery of transected sciatic nerves in rats". Experimental Biology and Medicine 246, n.º 11 (2 de marzo de 2021): 1287–96. http://dx.doi.org/10.1177/1535370221996655.
Resumen
This experimental research aimed to investigate the effects of non-thermal plasma on nerve regeneration after transected nerve damage using the sciatic nerve in Wistar albino (A) rats. The experiments were performed on 27 Wistar A rats. The rats underwent surgery for right sciatic nerve exposure and were divided into three groups (each group, n = 9) according to sciatic nerve transected injury (SNTI) and non-thermal plasma application: a non-nerve damage (non-ND) group, a only nerve damage without non-thermal plasma application (ND) group, and a nerve damage with non-thermal plasma application (ND + NTP) group. Subsequent to SNTI and immediate suture, non-thermal plasma was administered three times per week for eight weeks. Evaluation for functional recovery was performed using the static sciatic index measured over the full treatment period of eight weeks. The sciatic nerve specimens were obtained after euthanasia and third day from the last non-thermal plasma application. The sciatic nerve tissues were subjected to histological analysis. Behavior analysis presented that the ND + NTP group showed improved static sciatic index compared with the nerve damage group. Histopathological findings demonstrated that the ND + NTP group had more dense Schwann cells and well-established continuity of nerve fibers, greater than the nerve damage group. Immunohistochemistry showed that the ND + NTP group had increased levels of markers for microtubule-associated protein 2 (MAP2), tau, S100 calcium-binding protein B, and neurofilament-200 and regulated the overexpression of CD68 and MAP2. These results indicated that non-thermal plasma enhanced the motor function and restored the neuronal structure by accelerating myelination and axonal regeneration. Additionally, non-thermal plasma was confirmed to have a positive effect on the recovery of SNTI in rats.
20
Doshi, Pratik y Božena Šerá. "Role of Non-Thermal Plasma in Fusarium Inactivation and Mycotoxin Decontamination". Plants 12, n.º 3 (31 de enero de 2023): 627. http://dx.doi.org/10.3390/plants12030627.
Resumen
Fusarium spp. is a well-studied pathogen with the potential to infect cereals and reduce the yield to maximum if left unchecked. For decades, different control treatments have been tested against different Fusarium spp. and for reducing the mycotoxins they produce and are well documented. Some treatments also involved integrated pest management (IPM) strategies against Fusarium spp. control and mycotoxin degradation produced by them. In this review article, we compiled different control strategies against different Fusarium spp. In addition, special focus is given to the non-thermal plasma (NTP) technique used against Fusarium spp. inactivation. In a separate group, we compiled the literature about the use of NTP in the decontamination of mycotoxins produced by Fusarium spp., and highlighted the possible mechanisms of mycotoxin degradation by NTP. In this review, we concluded that although NTP is an effective treatment, it is a nice area and needs further research. The possibility of a prospective novel IPM strategy against Fusarium spp. is also proposed.
21
Baloul, Yasmine, Olivier Aubry, Hervé Rabat, Cyril Colas, Benoît Maunit y Dunpin Hong. "Paracetamol degradation in aqueous solution by non-thermal plasma". European Physical Journal Applied Physics 79, n.º 3 (4 de agosto de 2017): 30802. http://dx.doi.org/10.1051/epjap/2017160472.
Resumen
This study deals with paracetamol degradation in water using a non-thermal plasma (NTP) created by a dielectric barrier discharge (DBD). The effects of the NTP operating conditions on the degradation were studied, showing that the treatment efficiency of the process was highly dependent on the electrical parameters and working gas composition in the reactor containing the aqueous solution. A conversion rate higher than 99% was reached with an energy yield of 12 g/kWh. High resolution mass spectrometry (HRMS) measurements showed that the main species produced in water during the process were nitrogen compounds, carboxylic acids and aromatic compounds.
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Lin, Abraham, Jamoliddin Razzokov, Hanne Verswyvel, Angela Privat-Maldonado, Joey De Backer, Maksudbek Yusupov, Edgar Cardenas De La Hoz, Peter Ponsaerts, Evelien Smits y Annemie Bogaerts. "Oxidation of Innate Immune Checkpoint CD47 on Cancer Cells with Non-Thermal Plasma". Cancers 13, n.º 3 (2 de febrero de 2021): 579. http://dx.doi.org/10.3390/cancers13030579.
Resumen
Non-thermal plasma (NTP) therapy has been emerging as a promising cancer treatment strategy, and recently, its ability to locally induce immunogenic cancer cell death is being unraveled. We hypothesized that the chemical species produced by NTP reduce immunosuppressive surface proteins and checkpoints that are overexpressed on cancerous cells. Here, 3D in vitro tumor models, an in vivo mouse model, and molecular dynamics simulations are used to investigate the effect of NTP on CD47, a key innate immune checkpoint. CD47 is immediately modulated after NTP treatment and simulations reveal the potential oxidized salt-bridges responsible for conformational changes. Umbrella sampling simulations of CD47 with its receptor, signal-regulatory protein alpha (SIRPα), demonstrate that the induced-conformational changes reduce its binding affinity. Taken together, this work provides new insight into fundamental, chemical NTP-cancer cell interaction mechanisms and a previously overlooked advantage of present NTP cancer therapy: reducing immunosuppressive signals on the surface of cancer cells.
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Tvrdá, Eva, Daniel Lovíšek, Stanislav Kyzek, Dušan Kováčik y Eliška Gálová. "The Effect of Non-Thermal Plasma on the Structural and Functional Characteristics of Human Spermatozoa". International Journal of Molecular Sciences 22, n.º 9 (7 de mayo de 2021): 4979. http://dx.doi.org/10.3390/ijms22094979.
Resumen
Significant antibacterial properties of non-thermal plasma (NTP) have converted this technology into a promising alternative to the widespread use of antibiotics in assisted reproduction. As substantial data available on the specific in vitro effects of NTP on male reproductive cells are currently missing, this study was designed to investigate selected quality parameters of human spermatozoa (n = 51) exposed to diffuse coplanar surface barrier discharge NTP for 0 s, 15 s, 30 s, 60 s and 90 s. Sperm motility characteristics, membrane integrity, mitochondrial activity, production of reactive oxygen species (ROS), DNA fragmentation and lipid peroxidation (LPO) were investigated immediately following exposure to NTP and 2 h post-NTP treatment. Exposure to NTP with a power input of 40 W for 15 s or 30 s was found to have no negative effects on the sperm structure or function. However, a prolonged NTP treatment impaired all the sperm quality markers in a time- and dose-dependent manner. The most likely mechanism of action of high NTP doses may be connected to ROS overproduction, leading to plasma membrane destabilization, LPO, mitochondrial failure and a subsequent loss of motility as well as DNA integrity. As such, our findings indicate that appropriate plasma exposure conditions need to be carefully selected in order to preserve the sperm vitality, should NTP be used in the practical management of bacteriospermia in the future.
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Lee, Seon-Ki, Min-Kyung Ji, Yu-Jin Jo, Chan Park, Hoonsung Cho y Hyun-Pil Lim. "Effect of Non-Thermal Plasma Treatment of Contaminated Zirconia Surface on Porphyromonas gingivalis Adhesion and Osteoblast Viability". Materials 15, n.º 15 (3 de agosto de 2022): 5348. http://dx.doi.org/10.3390/ma15155348.
Resumen
Plasma treatment on a zirconia surface prevents bacterial contamination and maintains osteoblast activity. To assess the degree of adhesion of Porphyromonas gingivalis on a zirconia surface after non-thermal plasma (NTP) treatment, specimens were treated with plasma for 60, 300, and 600 s, after which P. gingivalis was inoculated onto the surface and incubated for 48 h. To assess osteoblast activity after NTP treatment, osteoblasts (MC3T3-E1) were dispensed onto the specimens contaminated with P. gingivalis immediately after NTP for 60 and 120 s, followed by incubation for 48, 72, and 96 h. P. gingivalis was cultured after 60 s of NTP treatment of zirconia. The NTP and control groups showed no significant difference (p = 0.91), but adhesion was significantly increased following NTP treatment for 300 s or longer (300, 600 s groups) (p < 0.05). After NTP treatment of P. gingivalis-contaminated zirconia, osteoblast activity significantly increased at 72 and 96 h (I60 and I120 s group) in the groups treated with plasma (p < 0.017). Application of NTP to dental zirconia implants for 60 s not only inhibits the proliferation of P. gingivalis, which causes peri-implantitis but also increases osseointegration on zirconia surfaces contaminated with P. gingivalis.
25
Khun, Josef, Anna Machková, Petra Kašparová, Myron Klenivskyi, Eva Vaňková, Pavel Galář, Jaroslav Julák y Vladimír Scholtz. "Non-Thermal Plasma Sources Based on Cometary and Point-to-Ring Discharges". Molecules 27, n.º 1 (31 de diciembre de 2021): 238. http://dx.doi.org/10.3390/molecules27010238.
Resumen
A non-thermal plasma (NTP) is a promising tool against the development of bacterial, viral, and fungal diseases. The recently revealed development of microbial resistance to traditional drugs has increased interest in the use of NTPs. We have studied and compared the physical and microbicidal properties of two types of NTP sources based on a cometary discharge in the point-to-point electrode configuration and a corona discharge in the point-to-ring electrode configuration. The electrical and emission properties of both discharges are reported. The microbicidal effect of NTP sources was tested on three strains of the bacterium Staphylococcus aureus (including the methicillin-resistant strain), the bacterium Pseudomonas aeruginosa, the yeast Candida albicans, and the micromycete Trichophyton interdigitale. In general, the cometary discharge is a less stable source of NTP and mostly forms smaller but more rapidly emerging inhibition zones on agar plates. Due to the point-to-ring electrode configuration, the second type of discharge has higher stability and provides larger affected but often not completely inhibited zones. However, after 60 min of exposure, the NTP sources based on the cometary and point-to-ring discharges showed a similar microbicidal effect for bacteria and an individual effect for microscopic fungi.
26
Lafontaine, Julie, Jean-Sébastien Boisvert, Audrey Glory, Sylvain Coulombe y Philip Wong. "Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines". Cancers 12, n.º 2 (4 de febrero de 2020): 348. http://dx.doi.org/10.3390/cancers12020348.
Resumen
Cancer therapy has evolved to a more targeted approach and often involves drug combinations to achieve better response rates. Non-thermal plasma (NTP), a technology rapidly expanding its application in the medical field, is a near room temperature ionized gas capable of producing reactive species, and can induce cancer cell death both in vitro and in vivo. Here, we used proliferation assay to characterize the plasma sensitivity of fourteen breast cancer cell lines. These assays showed that all tested cell lines were sensitive to NTP. In addition, a good correlation was found comparing cell sensitivity to NTP and radiation therapy (RT), where cells that were sensitive to RT were also sensitive to plasma. Moreover, in some breast cancer cell lines, NTP and RT have a synergistic effect. Adding a dose of PARP-inhibitor olaparib to NTP treatment always increases the efficacy of the treatment. Olaparib also exhibits a synergistic effect with NTP, especially in triple negative breast cancer cells. Results presented here help elucidate the position of plasma use as a potential breast cancer treatment.
27
Russo, Mariaconcetta, Giuseppina Iervolino, Vincenzo Vaiano y Vincenzo Palma. "Non-Thermal Plasma Coupled with Catalyst for the Degradation of Water Pollutants: A Review". Catalysts 10, n.º 12 (9 de diciembre de 2020): 1438. http://dx.doi.org/10.3390/catal10121438.
Resumen
Non-thermal plasma is one of the most promising technologies used for the degradation of hazardous pollutants in wastewater. Recent studies evidenced that various operating parameters influence the yield of the Non-Thermal Plasma (NTP)-based processes. In particular, the presence of a catalyst, suitably placed in the NTP reactor, induces a significant increase in process performance with respect to NTP alone. For this purpose, several researchers have studied the ability of NTP coupled to catalysts for the removal of different kind of pollutants in aqueous solution. It is clear that it is still complicated to define an optimal condition that can be suitable for all types of contaminants as well as for the various types of catalysts used in this context. However, it was highlighted that the operational parameters play a fundamental role. However, it is often difficult to understand the effect that plasma can induce on the catalyst and on the production of the oxidizing species most responsible for the degradation of contaminants. For this reason, the aim of this review is to summarize catalytic formulations coupled with non-thermal plasma technology for water pollutants removal. In particular, the reactor configuration to be adopted when NTP was coupled with a catalyst was presented, as well as the position of the catalyst in the reactor and the role of the main oxidizing species. Furthermore, in this review, a comparison in terms of degradation and mineralization efficiency was made for the different cases studied.
28
Andersen, K. B., A. Feilberg y J. A. Beukes. "Use of non-thermal plasma and UV-light for removal of odour from sludge treatment". Water Science and Technology 66, n.º 8 (1 de octubre de 2012): 1656–62. http://dx.doi.org/10.2166/wst.2012.367.
Resumen
Non-thermal plasma (NTP) systems can be used for abatement of odour nuisances. Odour reductions are achieved by radical-initiated oxidation and dust collection in the plasma reactor. For some emissions a sequence of NTP followed by UV-light can improve the odour reduction further. This study was conducted to evaluate the efficiency of NTP technology combined with UV-light towards odour emissions from sludge treatment. Air from a pilot sludge dryer was treated with a pilot NTP and a UV unit. The effect of using an acid scrubber upstream the NTP system was also tested. Thermal desorption gas chromatography and mass spectrometry (TD-GC/MS) was used to analyse samples taken from the inlet and the outlet of the NTP system. The TD-GC/MS used was also equipped with a sniffing port that made it possible to record odour-active compounds eluting from the column. Relative amounts of odour-active compounds in the inlet and the outlet flow from the NTP system were compared. Bag samples from inlet and outlet were also separately analysed by an external lab and by two operators using a one-man olfactometer, a modified NasalRangerTM. These results indicated a significant odour removal efficiency of 70–90% depending on the settings and combinations of abatement equipment.
29
Maillet, Christina, Florence M. Klein, Florian Le Bras, Frederic Velard, Christine Guillaume, Sophie C. Gangloff y Marie-Paule Gelle. "Cytocompatibility of titanium and poly(etheretherketone) surfaces after O2 non-thermal plasma sterilization". PLOS ONE 18, n.º 8 (30 de agosto de 2023): e0290820. http://dx.doi.org/10.1371/journal.pone.0290820.
Resumen
The sterilization of medical devices is paramount to achieve an acceptable level of sterility assurance and to prevent hospital-acquired infections. However, some medical devices cannot be sterilized by usual processes such as autoclave (AC) and gamma-ray irradiation (GI). A new non-thermal plasma (NTP) process using sealed bag that preserves the sterile state of the devices could be used as an alternative sterilization method. The aim of the study was to assess the cytocompatibility of titanium and poly(etheretherketone) (PEEK) surfaces after O2-NTP sterilization compared to GI and AC. MG-63 osteoblast-like cells were seeded on titanium (TA6V) and PEEK disks sterilized by AC, GI and O2-NTP. The cells’ viability and proliferation, determined by WST-1 and DNA quantification respectively, were enhanced whatever the material types from 3 to 10 days. When seeded on titanium, MG-63 cells showed a higher viability and proliferation after GI and O2-NTP treatment compared to AC treatment. When cultured on PEEK, MG-63 cells showed a higher viability after O2-NTP treatment. No difference of proliferation was observed whatever the sterilization processes. The cell colonization of the materials’ surface was confirmed by scanning electron microscopy. Lactate dehydrogenase (LDH) assay revealed no cytotoxicity. Thus, O2-NTP led to similar cell responses to AC and GI and could be a cost-effective alternative process to the usual sterilization methods for fragile medical devices.
30
Mildaziene, Vida, Anatolii Ivankov, Bozena Sera y Danas Baniulis. "Biochemical and Physiological Plant Processes Affected by Seed Treatment with Non-Thermal Plasma". Plants 11, n.º 7 (23 de marzo de 2022): 856. http://dx.doi.org/10.3390/plants11070856.
Resumen
Among the innovative technologies being elaborated for sustainable agriculture, one of the most rapidly developing fields relies on the positive effects of non-thermal plasma (NTP) treatment on the agronomic performance of plants. A large number of recent publications have indicated that NTP effects are far more persistent and complex than it was supposed before. Knowledge of the molecular basis and the resulting outcomes of seed treatment with NTP is rapidly accumulating and requires to be analyzed and presented in a systematic way. This review focuses on the biochemical and physiological processes in seeds and plants affected by seed treatment with NTP and the resulting impact on plant metabolism, growth, adaptability and productivity. Wide-scale changes evolving at the epigenomic, transcriptomic, proteomic and metabolic levels are triggered by seed irradiation with NTP and contribute to changes in germination, early seedling growth, phytohormone amounts, metabolic and defense enzyme activity, secondary metabolism, photosynthesis, adaptability to biotic and abiotic stress, microbiome composition, and increased plant fitness, productivity and growth on a longer time scale. This review highlights the importance of these novel findings, as well as unresolved issues that remain to be investigated.
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Mohamed, Hager, Eric Gebski, Rufranshell Reyes, Samuel Beane, Brian Wigdahl, Fred C. Krebs, Katharina Stapelmann y Vandana Miller. "Differential Effect of Non-Thermal Plasma RONS on Two Human Leukemic Cell Populations". Cancers 13, n.º 10 (18 de mayo de 2021): 2437. http://dx.doi.org/10.3390/cancers13102437.
Resumen
Non-thermal plasma application to cancer cells is known to induce oxidative stress, cytotoxicity and indirect immunostimulatory effects on antigen presenting cells (APCs). The purpose of this study was to evaluate the responses of two leukemic cell lines—Jurkat T lymphocytes and THP-1 monocytes—to NTP-generated reactive oxygen and nitrogen species (RONS). Both cell types depleted hydrogen peroxide, but THP-1 cells neutralized it almost immediately. Jurkat cells transiently blunted the frequency-dependent increase in nitrite concentrations in contrast to THP-1 cells, which exhibited no immediate effect. A direct relationship between frequency-dependent cytotoxicity and mitochondrial superoxide was observed only in Jurkat cells. Jurkat cells were very responsive to NTP in their display of calreticulin and heat shock proteins 70 and 90. In contrast, THP-1 cells were minimally responsive or unresponsive. Despite no NTP-dependent decrease in cell surface display of CD47 in either cell line, both cell types induced migration of and phagocytosis by APCs. Our results demonstrate that cells modulate the RONS-mediated changes in liquid chemistry, and, importantly, the resultant immunomodulatory effects of NTP can be independent of NTP-induced cytotoxicity.
32
Lokajová, Eliška, Jaroslav Julák, Josef Khun, Hana Soušková, Radim Dobiáš, Jaroslav Lux y Vladimír Scholtz. "Inactivation of Dermatophytes Causing Onychomycosis Using Non-Thermal Plasma as a Prerequisite for Therapy". Journal of Fungi 7, n.º 9 (31 de agosto de 2021): 715. http://dx.doi.org/10.3390/jof7090715.
Resumen
Following our previous study of the therapy of onychomycosis by non-thermal plasma (NTP) and nail hygiene and to obtain some prerequisite data of dermatophytes sensitivity, the dynamics of those inactivation by NTP plasma was monitored for various strains of Trichophyton iterdigitale, Trichophyton benhamiae, Trichophyton rubrum, and Microsporum canis. Three strains of each species on agar plates were exposed with plasma produced by a DC corona discharge in the point-to-ring arrangement in various time intervals. Although all strains were sufficiently sensitive to plasma action, significant differences were observed in their sensitivity and inactivation dynamics. These differences did not correlate with the species classification of individual strains, but could be assigned to four arbitrarily created types of strain response to NTP according to their sensitivity. These results indicate that the sensitivity to plasma is not an inherent property of the fungal species, but varies from strain to strain.
33
Smolková, Barbora, Adam Frtús, Mariia Uzhytchak, Mariia Lunova, Šárka Kubinová, Alexandr Dejneka y Oleg Lunov. "Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective". International Journal of Molecular Sciences 21, n.º 17 (28 de agosto de 2020): 6226. http://dx.doi.org/10.3390/ijms21176226.
Resumen
The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments.
34
Kim, Han-Jun, Eun-Wook Choi, Eun-Ji Choi, Hyo-Sung Kim, Junggil Kim, Guangsup Cho, Heesu Kim et al. "Non-thermal plasma promotes hair growth by improving the inter-follicular macroenvironment". RSC Advances 11, n.º 45 (2021): 27880–96. http://dx.doi.org/10.1039/d1ra04625j.
35
Arguello-Sánchez, Raúl, Régulo López-Callejas, Benjamín Gonzalo Rodríguez-Méndez, Rogelio Scougall-Vilchis, Ulises Velázquez-Enríquez, Antonio Mercado-Cabrera, Rosendo Peña-Eguiluz, Raúl Valencia-Alvarado y Carlo Eduardo Medina-Solís. "Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection". Materials 16, n.º 22 (17 de noviembre de 2023): 7204. http://dx.doi.org/10.3390/ma16227204.
Resumen
Non-thermal plasmas (NTPs), known as cold atmospheric plasmas (CAPs), hold great potential for diverse medical applications, including dentistry. However, traditional linear and rigid dielectric barrier discharge reactors used for NTP generation encounter limitations in accessing oral cavities and root canals. To address this issue, we have developed an innovative NTP reactor featuring an angled end for improved accessibility. The central copper electrode, with a 0.59 mm diameter and adjustable length for desired angulation, is coated with zircon powder (ZrSiO4) to ensure stable NTP generation. This central electrode is housed within a stainless steel tube (3 mm internal diameter, 8 mm external diameter, and 100 mm length) with a 27° angle at one end, making it ergonomically suitable for oral applications. NTP generation involves polarizing the reactor electrodes with 13.56 MHz radio frequency signals, using helium gas as a working medium. We introduce plasma-treated water (PTW) as an adjunctive therapy to enhance biofilm eradication within root canals. A synergistic approach combining NTP and PTW is employed and compared to the gold standard (sodium hypochlorite, NaOCl), effectively neutralizing Enterococcus faecalis bacteria, even in scenarios involving biofilms. Moreover, applying NTP in both gaseous and liquid environments successfully achieves bacterial inactivation at varying treatment durations, demonstrating the device’s suitability for medical use in treating root canal biofilms. The proposed NTP reactor, characterized by its innovative design, offers a practical and specific approach to plasma treatment in dental applications. It holds promise in combatting bacterial infections in root canals and oral cavities.
36
Gutiérrez-León, Diana Guadalupe, Tomás Serrano-Ramírez, Régulo López-Callejas y Benjamín Gonzalo Rodríguez-Méndez. "Non-Thermal Plasma as an Alternative to Enhance the Early Growth Structures in Lentil Plants". Agronomy 12, n.º 12 (23 de noviembre de 2022): 2920. http://dx.doi.org/10.3390/agronomy12122920.
Resumen
The scarcity and contamination of water, aggravated by the effects of Climate Change, endanger the food supply, cause health problems to humans, and are a critical concern. New research has been carried out to improve the quality of water used in the agricultural sector. One of them is the technology of non-thermal plasma (NTP) generated by corona discharges using air as a working gas. In this study, the NTP is applied directly and causing the activation to three water sources: potable, wastewater from poultry farming, and rain, on the legume “lentil.” The results show that the NTP applied to the different water conditions modifies the legume structure, obtaining a better germination and growth rate. In particular, it found that the best condition to stimulate the plant structure growth is using wastewater from poultry activities, which NTP activates. Likewise, it identified the internalization of pathogenic microorganisms such as Escherichia coli and Salmonella typhimurium since the early development of the plant. The bacteria reduction after NTP application is detected due to the effect of the reactive species generated by the NTP. The NTP application for water activation can represent an alternative to solve the demand for food since the development of the structures of legumes, particularly of lentils, is promoted.
37
Wang, Zongyu, Hailang Kuang, Jifeng Zhang, Lilin Chu y Yulong Ji. "Nitrogen oxide removal by non-thermal plasma for marine diesel engines". RSC Advances 9, n.º 10 (2019): 5402–16. http://dx.doi.org/10.1039/c8ra09217f.
38
Ibáñez-Mancera, Norma Guadalupe, Régulo López-Callejas, Víctor Hugo Toral-Rizo, Benjamín Gonzalo Rodríguez-Méndez, Edith Lara-Carrillo, Rosendo Peña-Eguiluz, Regiane Cristina do Amaral, Antonio Mercado-Cabrera y Raúl Valencia-Alvarado. "Healing of Recurrent Aphthous Stomatitis by Non-Thermal Plasma: Pilot Study". Biomedicines 11, n.º 1 (9 de enero de 2023): 167. http://dx.doi.org/10.3390/biomedicines11010167.
Resumen
Recurrent aphthous stomatitis (RAS) is a common disease in the oral cavity characterized by recurrent ulcers (RU). Usually, these cause acute pain without definitive treatment. The present study determines the efficacy of non-thermal plasma (NTP) for treating RU. NTP is applied to the patient’s RU using a radiofrequency generator connected to a point reactor. The power density applied to the ulcer is 0.50 W/cm2, less than 4 W/cm2, which is the maximum value without biological risk. Each patient received two treatments of three minutes each and spaced 60 min apart at a distance of 5 mm from the RU. From a sample of 30 ulcers in patients treated for RU with an average age of 37 years, they stated that the pain decreased considerably and without the need for ingestion of analgesics and antibiotics. Regeneration took place in an average of three days. The NTP proved to be an excellent therapeutic alternative for the treatment of RU since it has a rapid effect of reducing pain and inflammation, as well as adequate tissue regeneration.
39
Yang, Yuhan, Yuan Wang, Shang Wei, Xianzhong Wang y Jiaojiao Zhang. "Effects and Mechanisms of Non-Thermal Plasma-Mediated ROS and Its Applications in Animal Husbandry and Biomedicine". International Journal of Molecular Sciences 24, n.º 21 (2 de noviembre de 2023): 15889. http://dx.doi.org/10.3390/ijms242115889.
Resumen
Non-thermal plasma (NTP) is an ionized gas composed of neutral and charged reactive species, electric fields, and ultraviolet radiation. NTP presents a relatively low discharge temperature because it is characterized by the fact that the temperature values of ions and neutral particles are much lower than that of electrons. Reactive species (atoms, radicals, ions, electrons) are produced in NTP and delivered to biological objects induce a set of biochemical processes in cells or tissues. NTP can mediate reactive oxygen species (ROS) levels in an intensity- and time-dependent manner. ROS homeostasis plays an important role in animal health. Relatively low or physiological levels of ROS mediated by NTP promote cell proliferation and differentiation, while high or excessive levels of ROS mediated by NTP cause oxidative stress damage and even cell death. NTP treatment under appropriate conditions not only produces moderate levels of exogenous ROS directly and stimulates intracellular ROS generation, but also can regulate intracellular ROS levels indirectly, which affect the redox state in different cells and tissues of animals. However, the treatment condition of NTP need to be optimized and the potential mechanism of NTP-mediated ROS in different biological targets is still unclear. Over the past ten decades, interest in the application of NTP technology in biology and medical sciences has been rapidly growing. There is significant optimism that NTP can be developed for a wide range of applications such as wound healing, oral treatment, cancer therapy, and biomedical materials because of its safety, non-toxicity, and high efficiency. Moreover, the combined application of NTP with other methods is currently a hot research topic because of more effective effects on sterilization and anti-cancer abilities. Interestingly, NTP technology has presented great application potential in the animal husbandry field in recent years. However, the wide applications of NTP are related to different and complicated mechanisms, and whether NTP-mediated ROS play a critical role in its application need to be clarified. Therefore, this review mainly summarizes the effects of ROS on animal health, the mechanisms of NTP-mediated ROS levels through antioxidant clearance and ROS generation, and the potential applications of NTP-mediated ROS in animal growth and breeding, animal health, animal-derived food safety, and biomedical fields including would healing, oral treatment, cancer therapy, and biomaterials. This will provide a theoretical basis for promoting the healthy development of animal husbandry and the prevention and treatment of diseases in both animals and human beings.
40
Hsueh, Ming-Hsien, Chia-Nan Wang, Meng-Chang Hsieh, Chao-Jung Lai, Shi-Hao Wang, Chia-Hsin Hsieh, Tsung-Liang Wu y Jo-Hung Yu. "An Analysis of Exhaust Emission of the Internal Combustion Engine Treated by the Non-Thermal Plasma". Molecules 25, n.º 24 (21 de diciembre de 2020): 6041. http://dx.doi.org/10.3390/molecules25246041.
Resumen
Industries’ air pollution causes serious challenges to modern society, among them exhaust gases from internal combustion engines, which are currently one of the main sources. This study proposes a non-thermal plasma (NTP) system for placement in the exhaust system of internal combustion engines to reduce the toxic contaminants (HC, CO, and NOx) of exhaust gases. This NTP system generates a high-voltage discharge that not only responds to the ion chemical reaction to eliminate NOx and CO, but that also generates a combustion reaction at the local high temperature of plasma to reduce HC. The NTP system was designed on both the front and rear of the exhaust pipe to analyze the difference of different exhaust flow rates under the specified frequency. The results indicate that the NTP system can greatly reduce toxic contaminants. The NTP reactor placed in the front of exhaust pipe gave HC and CO removal efficiency of about 34.5% and 16.0%, respectively, while the NTP reactor placed in the rear of exhaust pipe gave NOx removal efficiency of about 41.3%. In addition, the voltage and material directly affect the exhaust gases obviously. In conclusion, the proposed NTP system installed in the exhaust system can significantly reduce air pollutants. These results suggest that applying NTP to the combustion engine should be a useful tool to simultaneously reduce both emissions of NOx and CO.
41
Katiyar, Kritika S., Abraham Lin, Alexander Fridman, Carolyn E. Keating, D. Kacy Cullen y Vandana Miller. "Non-Thermal Plasma Accelerates Astrocyte Regrowth and Neurite Regeneration Following Physical Trauma In Vitro". Applied Sciences 9, n.º 18 (8 de septiembre de 2019): 3747. http://dx.doi.org/10.3390/app9183747.
Resumen
Non-thermal plasma (NTP), defined as a partially ionized gas, is an emerging technology with several biomedical applications, including tissue regeneration. In particular, NTP treatment has been shown to activate endogenous biological processes to promote cell regrowth, differentiation, and proliferation in multiple cell types. However, the effects of this therapy on nervous system regeneration have not yet been established. Accordingly, the current study explored the effects of a nanosecond-pulsed dielectric barrier discharge plasma on neural regeneration. Following mechanical trauma in vitro, plasma was applied either directly to (1) astrocytes alone, (2) neurons alone, or (3) neurons or astrocytes in a non-contact co-culture. Remarkably, we identified NTP treatment intensities that accelerated both neurite regeneration and astrocyte regrowth. In astrocyte cultures alone, an exposure of 20–90 mJ accelerated astrocyte re-growth up to three days post-injury, while neurons required lower treatment intensities (≤20 mJ) to achieve sub-lethal outgrowth. Following injury to neurons in non-contact co-culture with astrocytes, 20 mJ exposure of plasma to only neurons or astrocytes resulted in increased neurite regeneration at three days post-treatment compared to the untreated, but no enhancement was observed when both cell types were treated. At day seven, although regeneration further increased, NTP did not elicit a significant increase from the control. However, plasma exposure at higher intensities was found to be injurious, underscoring the need to optimize exposure levels. These results suggest that growth-promoting physiological responses may be elicited via properly calibrated NTP treatment to neurons and/or astrocytes. This could be exploited to accelerate neurite re-growth and modulate neuron-astrocyte interactions, thereby hastening nervous system regeneration.
42
Shi, Yun Xi, Yi Xi Cai, Kang Hua Li, Xiao Hua Li y Ya Yun Chen. "Experimental Study on the DPF Regeneration Based on Non-Thermal Plasma Technology". Applied Mechanics and Materials 325-326 (junio de 2013): 1347–51. http://dx.doi.org/10.4028/www.scientific.net/amm.325-326.1347.
Resumen
Diesel particulate filter (DPF) are considered to be the most effective means to reduce particulate emissions, and the key of DPF lies in their regeneration. O3 and O which have strong oxidability can be produced by non-thermal plasma (NTP) reactor. PM can be decomposed by these active substances to generate CO and CO2. The results show that PM deposited in the DPF can be removed by NTP technology without any catalyst and DPF can be completely regenerated at a lower temperature.
43
Sutter, Julia, Jascha Brettschneider, Brian Wigdahl, Peter J. Bruggeman, Fred C. Krebs y Vandana Miller. "Non-Thermal Plasma Reduces HSV-1 Infection of and Replication in HaCaT Keratinocytes In Vitro". International Journal of Molecular Sciences 25, n.º 7 (29 de marzo de 2024): 3839. http://dx.doi.org/10.3390/ijms25073839.
Resumen
Herpes simplex virus type 1 (HSV-1) is a lifelong pathogen characterized by asymptomatic latent infection in the trigeminal ganglia (TG), with periodic outbreaks of cold sores caused by virus reactivation in the TG and subsequent replication in the oral mucosa. While antiviral therapies can provide relief from cold sores, they are unable to eliminate HSV-1. We provide experimental results that highlight non-thermal plasma (NTP) as a new alternative therapy for HSV-1 infection that would resolve cold sores faster and reduce the establishment of latent infection in the TG. Additionally, this study is the first to explore the use of NTP as a therapy that can both treat and prevent human viral infections. The antiviral effect of NTP was investigated using an in vitro model of HSV-1 epithelial infection that involved the application of NTP from two separate devices to cell-free HSV-1, HSV-1-infected cells, and uninfected cells. It was found that NTP reduced the infectivity of cell-free HSV-1, reduced viral replication in HSV-1-infected cells, and diminished the susceptibility of uninfected cells to HSV-1 infection. This triad of antiviral mechanisms of action suggests the potential of NTP as a therapeutic agent effective against HSV-1 infection.
44
Ahn, Jong-Ju, Dae-Sung Kim, Eun-Bin Bae, Gyoo-Cheon Kim, Chang-Mo Jeong, Jung-Bo Huh y So-Hyoun Lee. "Effect of Non-Thermal Atmospheric Pressure Plasma (NTP) and Zirconia Primer Treatment on Shear Bond Strength between Y-TZP and Resin Cement". Materials 13, n.º 18 (5 de septiembre de 2020): 3934. http://dx.doi.org/10.3390/ma13183934.
Resumen
The purpose of this study was to investigate the effect of non-thermal atmospheric pressure plasma (NTP) treatment on the sandblasting of mechanical method and zirconia primer of chemical method used to increase the bond strength between zirconia and resin cement. In this study, Y-TZP was divided into 4 groups according to the surface treatment methods as follows: Zirconia primer (Pr), NTP + Zirconia primer (NTP + Pr), Sandblasting + Zirconia primer (Sb + Pr), Sandblasting + NTP + Zirconia primer (Sb + NTP + Pr). Then, two types of resin cement (G-CEM LinkAce and Rely X-U200) were used to measure the shear bond strength (SBS) and they were divided into non-thermal cycling group and thermal cycling group for aging effect. Statistical analyses were performed using the Kruskal-Wallis test and Mann-Whitney U test. The result of the surface energy (SE), there was no significant difference among the groups (p > 0.05). As a result of the SBS test, the Sb + Pr group had a significantly higher SBS value than the other groups regardless of the resin cement type (p < 0.05), and the decrease rate after thermal cycling treatment was the lowest. On the other hand, the NTP + Pr group showed significantly lower SBS values than the other groups except for the case of using Rely X-U200 (p < 0.05), and the reduction rate after thermal cycling was the highest. The Sb + NTP + Pr group did not differ significantly from the Pr group (p > 0.05). Within the limitations of two successive studies, treatment with NTP after sandblasting used for mechanical bond strength showed a positive effect on initial SBS. However, when NTP was treated before the zirconia primer used for the chemical bond strength, it showed a negative effect on SBS compared to other treatment methods, which was noticeable after the thermal cycling treatment.
45
Abiev, Rufat Sh, Dmitry A. Sladkovskiy, Kirill V. Semikin, Dmitry Yu Murzin y Evgeny V. Rebrov. "Non-Thermal Plasma for Process and Energy Intensification in Dry Reforming of Methane". Catalysts 10, n.º 11 (22 de noviembre de 2020): 1358. http://dx.doi.org/10.3390/catal10111358.
Resumen
Plasma-assisted dry reforming of methane (DRM) is considered as a potential way to convert natural gas into fuels and chemicals under near ambient temperature and pressure; particularly for distributed processes based on renewable energy. Both catalytic and photocatalytic technologies have been applied for DRM to investigate the CH4 conversion and the energy efficiency of the process. For conventional catalysis; metaldoped Ni-based catalysts are proposed as a leading vector for further development. However; coke deposition leads to fast deactivation of catalysts which limits the catalyst lifetime. Photocatalysis in combination with non-thermal plasma (NTP), on the other hand; is an enabling technology to convert CH4 to more reactive intermediates. Placing the catalyst directly in the plasma zone or using post-plasma photocatalysis could generate a synergistic effect to increase the formation of the desired products. In this review; the recent progress in the area of NTP-(photo)catalysis applications for DRM has been described; with an in-depth discussion of novel plasma reactor types and operational conditions including employment of ferroelectric materials and nanosecond-pulse discharges. Finally, recent developments in the area of optical diagnostic tools for NTP, such as optical emission spectroscopy (OES), in-situ FTIR, and tunable diode laser absorption spectroscopy (TDLAS), are reviewed.
46
Kim, Sun-Yong, Hyo Jeong Kim, Haeng Jun Kim y Chul-Ho Kim. "Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination". Cells 9, n.º 3 (2 de marzo de 2020): 595. http://dx.doi.org/10.3390/cells9030595.
Resumen
Non-thermal plasma (NTP) has been studied as a novel therapeutic tool for cancer that does not damage healthy cells. In this study, we show that NTP-treated solutions (NTS) can induce death in various leukemia cells through mechanistic target of rapamycin (mTOR) ubiquitination. Previously, we manufactured and demonstrated the efficacy of NTS in solid cancers. NTS did not exhibit any deleterious side effects, such as acute death or weight loss in nude mice. In the present study, NTS induced cell death in myeloid leukemia cells, including acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). We found that mTOR was downregulated in NTS-treated cells via the ubiquitin-proteasome system (UPS). We also identified ‘really interesting new gene’ finger protein 126 (RNF126) as a novel binding protein for mTOR through protein arrays and determined the role of E3 ligase in NTS-induced mTOR ubiquitination. NTS-derived reactive oxygen species (ROS) affected RNF126 expression and lysosomal dysfunction. These findings suggest that NTS has potential antileukemic effects through RNF126-mediated mTOR ubiquitination with no deleterious side effects. Thus, NTS may represent a new therapeutic method for chemotherapy-resistant leukemia.
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Meloni, Eugenio, Liberato Cafiero, Marco Martino y Vincenzo Palma. "Structured Catalysts for Non-Thermal Plasma-Assisted Ammonia Synthesis". Energies 16, n.º 7 (3 de abril de 2023): 3218. http://dx.doi.org/10.3390/en16073218.
Resumen
Ammonia has been intensively studied as a clean, sustainable fuel source and an efficient energy storage medium due to its effectiveness as a hydrogen carrier molecule. However, the currently used Haber–Bosch process requires a large fossil fuel input, high temperatures and pressures, as well as a significant capital investment. These constraints prevent decentralized and small-scale ammonia production at the level of small farms and local communities. Non-thermal plasma (NTP) can promote ammonia synthesis in operating conditions in which, in a conventional process, a catalyst is generally not active. In this study, the production of NTP-assisted catalytic ammonia at milder temperatures and ambient pressure was investigated. Four different structured catalysts were prepared and tested using an experimental plant based on a dielectric barrier discharge (DBD) reactor. The effect of the gas hourly space velocity (GHSV) was investigated, as well as the effect of the N2/H2 ratio on catalyst performance. The results evidenced that the best catalytic activity (about 4 mmol h−1 of produced NH3) was obtained using the 10Ni/zeolite 13X sample with the lowest energy consumption, thus highlighting the feasibility of this innovative technology in this field.
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Meloni, Eugenio, Liberato Cafiero, Simona Renda, Marco Martino, Mariaconcetta Pierro y Vincenzo Palma. "Ru- and Rh-Based Catalysts for CO2 Methanation Assisted by Non-Thermal Plasma". Catalysts 13, n.º 3 (28 de febrero de 2023): 488. http://dx.doi.org/10.3390/catal13030488.
Resumen
The need to reduce the concentration of CO2 in the atmosphere is becoming increasingly necessary since it is considered the main factor responsible for climate change. Carbon Capture and Utilization (CCU) technology offers the opportunity to obtain a wide range of chemicals using this molecule as a raw material. In this work, the catalytic Non-Thermal Plasma (NTP)-assisted hydrogenation of CO2 to CH4 (methanation reaction) in a Dielectric Barrier Discharge (DBD) reactor was investigated. Four different Ru- and Rh-based catalysts were prepared starting from γ-Al2O3 spheres, characterized and tested in both thermal and NTP-assisted methanation under different operating conditions. The experimental tests evidenced the very positive effect of the NTP application on the catalytic performance, highlighting that for all the catalysts the same CO2 conversion was reached at a temperature 150 °C lower with respect to the conventional thermal reaction. Among the prepared catalysts, the bimetallic ones showed the best performance, reaching a CO2 conversion of 97% at about 180 °C with a lower energy consumption with respect to similar catalysts present in the literature.
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Kim, Dae-Sung, Jong-Ju Ahn, Gyoo-Cheon Kim, Chang-Mo Jeong, Jung-Bo Huh y So-Hyoun Lee. "Influence of Non-Thermal Atmospheric Pressure Plasma Treatment on Retentive Strength between Zirconia Crown and Titanium Implant Abutment". Materials 14, n.º 9 (1 de mayo de 2021): 2352. http://dx.doi.org/10.3390/ma14092352.
Resumen
The aim of this study is to investigate the effect of non-thermal atmospheric pressure plasma (NTP) on retentive strength (RS) between the zirconia crown and the titanium implant abutment using self-adhesive resin cement. Surface free energy (SFE) was calculated on 24 cube-shaped zirconia blocks, and RS was measured on 120 zirconia crown-titanium abutment assemblies bonded with G-CEM LinkAce. The groups were categorized according to the zirconia surface treatment as follows: Control (no surface treatment), NTP, Si (Silane), NTP + Si, Pr (Z-Prime Plus), and NTP + Pr. Half of the RS test assemblies were aged by thermocycling for 5000 cycles at 5–55 °C. The SFE was calculated using the Owens-Wendt method, and the RS was measured using a universal testing machine at the maximum load until failure. One-way analysis of variance (ANOVA) with post-hoc Tukey honestly significant difference (HSD) was performed to evaluate the effect of surface treatments on the SFE and RS. Independent sample t-test was used to compare the RS according to thermocycling (p < 0.05). For the SFE analysis, the NTP group had a significantly higher SFE value than the Control group (p < 0.05). For the RS test, in non-thermocycling, the NTP group showed a significantly higher RS value than the Control group (p < 0.05). However, in thermocycling, there was no significant difference between the Control and NTP groups (p > 0.05). In non-thermocycling, comparing with the NTP + Si or NTP + Pr group, there was no significant difference from the Si or Pr group, respectively (p > 0.05). Conversely, in thermocycling, the NTP + Si and NTP + Pr group had significantly lower RS than the Si and Pr group, respectively (p < 0.05). These results suggest that NTP single treatment for the zirconia crown increases the initial RS but has little effect on the long-term RS. Applied with Silane or Z-Prime Plus, NTP pre-treatment has no positive effect on the RS.
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Nayak, Vasudev Vivekanand, Nicholas Alexander Mirsky, Blaire V. Slavin, Lukasz Witek, Paulo G. Coelho y Nick Tovar. "Non-Thermal Plasma Treatment of Poly(tetrafluoroethylene) Dental Membranes and Its Effects on Cellular Adhesion". Materials 16, n.º 20 (10 de octubre de 2023): 6633. http://dx.doi.org/10.3390/ma16206633.
Resumen
Non-resorbable dental barrier membranes entail the risk of dehiscence due to their smooth and functionally inert surfaces. Non-thermal plasma (NTP) treatment has been shown to increase the hydrophilicity of a biomaterials and could thereby enhance cellular adhesion. This study aimed to elucidate the role of allyl alcohol NTP treatment of poly(tetrafluoroethylene) in its cellular adhesion. The materials (non-treated PTFE membranes (NTMem) and NTP-treated PTFE membranes (PTMem)) were subjected to characterization using scanning electron microscopy (SEM), contact angle measurements, X-ray photoelectron spectroscopy (XPS), and electron spectroscopy for chemical analysis (ESCA). Cells were seeded upon the different membranes, and cellular adhesion was analyzed qualitatively and quantitatively using fluorescence labeling and a hemocytometer, respectively. PTMem exhibited higher surface energies and the incorporation of reactive functional groups. NTP altered the surface topography and chemistry of PTFE membranes, as seen through SEM, XPS and ESCA, with partial defluorination and polymer chain breakage. Fluorescence labeling indicated significantly higher cell populations on PTMem relative to its untreated counterparts (NTMem). The results of this study support the potential applicability of allyl alcohol NTP treatment for polymeric biomaterials such as PTFE—to increase cellular adhesion for use as dental barrier membranes.