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Artículos de revistas sobre el tema "Non-clinical studies"

Autor: Grafiati
Publicado: 25 de mayo de 2024

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1

Sitruk-Ware, R. "Non-clinical studies of progesterone". Climacteric 21, n.º 4 (23 de mayo de 2018): 315–20. http://dx.doi.org/10.1080/13697137.2018.1463982.

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Swanson, Steven J. y Jeanine Bussiere. "Immunogenicity assessment in non-clinical studies". Current Opinion in Microbiology 15, n.º 3 (junio de 2012): 337–47. http://dx.doi.org/10.1016/j.mib.2012.05.015.

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3

Molinier, B., M. Henriquet, N. Fourcine y B. Remandet. "Functional immunotoxicity assays in non-clinical studies". Toxicology Letters 205 (agosto de 2011): S149. http://dx.doi.org/10.1016/j.toxlet.2011.05.528.

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4

Franco, Raúl, Juan M. Rodriguez, Fernanda Elías, Andrés Hernando-Insúa, Juan Fló, Ricardo López, Carlos Nagle et al. "Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide". Nucleic Acid Therapeutics 24, n.º 4 (agosto de 2014): 267–82. http://dx.doi.org/10.1089/nat.2013.0479.

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5

Le Tourneau, C., M. Kamal, O. Tredan, C. Gomez-Roca, M. Campone, A. Goncalves, N. Isambert et al. "Poster session 7. Clinical Studies - non-phase 1". Annals of Oncology 24, suppl 1 (1 de marzo de 2013): i36. http://dx.doi.org/10.1093/annonc/mdt049.

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6

Singer, C. R. J. y A. H. Goldstone. "Clinical studies of ABMT in non-Hodgkin's lymphoma". Clinics in Haematology 15, n.º 1 (febrero de 1986): 105–50. http://dx.doi.org/10.1016/s0308-2261(86)80008-x.

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7

AWAZU, Shoji. "ISSUES ABOUT CURRENT “GUIDELINES FOR NON - CLINICAL PHARMACOKINETIC STUDIES”". Drug Metabolism and Pharmacokinetics 11, supplement (1996): 5126–27. http://dx.doi.org/10.2133/dmpk.11.supplement_5126.

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8

AWAZU, Shoji. "Issues about Current "Guidelines for Non-Clinical Pharmacokinetic Studies"." Drug Metabolism and Pharmacokinetics 12, n.º 3 (1997): 217–18. http://dx.doi.org/10.2133/dmpk.12.217.

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9

Parnham, Michael J., Janice Schindler-Horvat y Marija Kozlović. "Non-Clinical Safety Studies on Biosimilar Recombinant Human Erythropoietin". Basic & Clinical Pharmacology & Toxicology 100, n.º 2 (22 de enero de 2007): 73–83. http://dx.doi.org/10.1111/j.1742-7843.2007.00028.x.

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10

SCHMITT, GERHARD J. "Principles for the conduct of non-drug clinical studies". International Journal of Cosmetic Science 16, n.º 1 (febrero de 1994): 39–43. http://dx.doi.org/10.1111/j.1467-2494.1994.tb00080.x.

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11

Bonomi, Philip. "Clinical studies with non-iressa EGFR tyrosine kinase inhibitors". Lung Cancer 41 (agosto de 2003): 43–48. http://dx.doi.org/10.1016/s0169-5002(03)00141-7.

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12

Makin, Andrew, Christina Skytte y Nanna Grand. "Use of minipigs in non-clinical juvenile toxicology studies". Toxicology 278, n.º 3 (diciembre de 2010): 373–74. http://dx.doi.org/10.1016/j.tox.2010.08.135.

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13

Barton, Bette Lee. "FDA's Inspections of US and Non-US Clinical Studies". Drug Information Journal 24, n.º 3 (julio de 1990): 463–68. http://dx.doi.org/10.1177/009286159002400303.

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14

Broome, Joseph L. "Main Non-Clinical Factors Influencing Endodontic Referral". Primary Dental Journal 5, n.º 3 (agosto de 2016): 64–69. http://dx.doi.org/10.1177/205016841600500307.

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Specialisation in endodontics allows for endodontic referrals by general dental practitioner (GDPs) and the study of factors influencing referral. These centre on a triad consisting of the referral process, non-clinical and clinical reasons for referral. Many non-clinical factors have been identified which may influence the referral process to the endodontist. A systematic review study was undertaken into the main non-clinical factors influencing endodontic referral by general dental practitioners to endodontists. Such awareness and appreciation of these factors benefits the commercial aspect of the referral practice, increases access by reducing barriers to care, and ultimately improves patient care. A literature search yielded three papers that met the eligibility criteria. All studies included were cross sectional survey studies completed by GDPs. The main non-clinical factors seen from the studies include: • Availability. • Personality, relationships and communication. • Location. Availability presented as a common thread throughout all the studies. In conclusion, endodontic referral is multifactorial and influenced by several factors, that are not related to the nature of the endodontic disease, and this is a dynamic process. Due to the lack of high level studies, and limitations of the available studies, further research is suggested into relevant area of non-clinical endodontic factors for endodontic referral and thus allowing for further analysis.
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15

Asiamah, Nestor, Henry Kofi Mensah y Eric Fosu Oteng-Abayie. "Non-Probabilistic Sampling in Quantitative Clinical Research". International Journal of Applied Research on Public Health Management 7, n.º 1 (enero de 2022): 1–18. http://dx.doi.org/10.4018/ijarphm.290379.

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Quantitative researchers need a probabilistic sample to generalise their findings, but research constraints often compel them to use non-probabilistic samples. The use of non-probability sampling methods in quantitative studies has therefore become a norm. Interestingly, even studies published in top-quality journals compromise best practices that the use of non-probabilistic samples requires. Based on a thorough review of relevant studies, we developed a typology of non-probability sampling methods used in quantitative health studies. An attempt was made to discuss the limit of inference under each type of non-probability sampling method. Non-probability sampling in quantitative research was also delineated as a way to maximise response rate. This study is expected to guide students and early career epidemiologists to understand how to apply non-probabilistic sampling methods in quantitative approaches and plausibly document or report their chosen methods.
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16

Sasahara, Kunihiro. "Timing of Non-Clinical Safety Studies for Conduct of Clinical Trials -Pharmacokinetic Considerations". Drug Metabolism and Pharmacokinetics 12, supplement (1997): 140. http://dx.doi.org/10.2133/dmpk.12.supplement_140.

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17

Weingand, K. W. "International harmonisation of clinical pathology testing for non-clinical toxicity and safety studies". Comparative Haematology International 3, n.º 3 (septiembre de 1993): 164–67. http://dx.doi.org/10.1007/bf00186101.

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18

Sacaan, Aida, Satoko Nonaka Hashida y Nasir K. Khan. "Non-clinical combination toxicology studies: strategy, examples and future perspective". Journal of Toxicological Sciences 45, n.º 7 (2020): 365–71. http://dx.doi.org/10.2131/jts.45.365.

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19

Tim, Richard W., John R. Gilbert, Jeffrey M. Stajich, Evadnie Rampersaud, Kristi D. Viles, Rabi Tawil, George W. Padberg et al. "Clinical Studies in Non-chromosome 4-Linked Facioscapulohumeral Muscular Dystrophy". Journal of Clinical Neuromuscular Disease 3, n.º 1 (septiembre de 2001): 1–7. http://dx.doi.org/10.1097/00131402-200109000-00001.

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20

Stephan-Gueldner, M., H. Buergin, J. Funk, H. P. Grimm, M. Sanders, T. S. Zabka, T. Singer y M. Bergstroem. "Opportunities for in vivo imaging in non-clinical safety studies". Toxicology Letters 205 (agosto de 2011): S24. http://dx.doi.org/10.1016/j.toxlet.2011.05.097.

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21

Champeroux, Pascal, Eric Martel, John Sinclair Lawrence Fowler, Anne Maurin, Marie Laure Sola, Sébastien Jude, Francine Elamrani et al. "Calculation of QT shift in non clinical safety pharmacology studies". Journal of Pharmacological and Toxicological Methods 59, n.º 2 (marzo de 2009): 73–85. http://dx.doi.org/10.1016/j.vascn.2008.11.001.

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22

Champeroux, Pascal, Eric Martel, Anne Maurin, Marie Laure Sola, Sbastien Jud, Francine El Amrani, Andre Anne Weyn, Arnaud Laveissire, Patricia Lala y Serge Richard. "Calculation of QT shift in non clinical safety pharmacology studies". Journal of Pharmacological and Toxicological Methods 62, n.º 2 (septiembre de 2010): e20. http://dx.doi.org/10.1016/j.vascn.2010.11.069.

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23

Matsumoto, Mineo, Shinichi Komatsu, Mayumi Tsuchimoto, Hajime Matsui, Kazuto Watanabe, Kazuichi Nakamura, Kohei Amakasu et al. "Considerations for non-clinical safety studies of therapeutic peptide vaccines". Regulatory Toxicology and Pharmacology 70, n.º 1 (octubre de 2014): 254–60. http://dx.doi.org/10.1016/j.yrtph.2014.06.029.

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24

Stamatas, G. "Dermal Penetration: Models and Non-Invasive Measurements for Clinical Studies". Toxicology Letters 238, n.º 2 (octubre de 2015): S50. http://dx.doi.org/10.1016/j.toxlet.2015.08.140.

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25

Leighton, John K., Joseph DeGeorge, David Jacobson-Kram, James MacGregor, Donna Mendrick y Alexandra Worobec. "Pharmacogenomic data submissions to the FDA: non-clinical case studies". Pharmacogenomics 5, n.º 5 (julio de 2004): 507–11. http://dx.doi.org/10.1517/14622416.5.5.507.

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26

Guangying, Du, Ma Shuzhi, Zhu Xiaoyin, Yu Pengfei, Yu Xin, Ye Liang, Shao Xin et al. "Non-clinical pharmacology and toxicology studies of bevacizumab biosimilar LY01008". European Journal of Pharmacology 936 (diciembre de 2022): 175383. http://dx.doi.org/10.1016/j.ejphar.2022.175383.

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27

Bailly, M., C. Perret, N. Truchot, L. Penard y E. Drevon-Gaillot. "Retrospective analysis on the tolerability of non-standard used vehicles in non-clinical studies". Toxicology Letters 350 (septiembre de 2021): S177. http://dx.doi.org/10.1016/s0378-4274(21)00659-7.

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28

Vas, A. y B. Gulyas. "Clinical and non clinical positron emission tomography (PET) studies on vinpocetine, a neuroprotective drug". Journal of the Neurological Sciences 283, n.º 1-2 (agosto de 2009): 266. http://dx.doi.org/10.1016/j.jns.2009.02.107.

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29

Derakhchan, Katayoun, Zhen Lou, Hong Wang y Robert Baughman. "Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies". Drugs in Context 12 (27 de febrero de 2023): 1–16. http://dx.doi.org/10.7573/dic.2022-6-1.

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30

Bulli, Francesco, Gabriele Melli, Claudia Carraresi, Eleonora Stopani, Alberto Pertusa y Randy O. Frost. "Hoarding Behaviour in an Italian Non-Clinical Sample". Behavioural and Cognitive Psychotherapy 42, n.º 3 (4 de enero de 2013): 297–311. http://dx.doi.org/10.1017/s1352465812001105.

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Background: Hoarding is associated with significant impairment. Although traditionally considered as a symptom of obsessive-compulsive disorder (OCD), some authors have proposed that pathological hoarding could be considered as a stand alone condition. The prevalence of pathological hoarding behaviour has been shown to be high in some countries, but little is known about the prevalence and correlates of hoarding in the non-clinical population in Italy. Method: We studied the prevalence of self-reported hoarding behaviour using the Italian version of the Saving Inventory-Revised, as well as the association between hoarding and various clinical correlates, including obsessive-compulsive symptoms, compulsive buying, anxiety, and depression. Results: The prevalence of pathological hoarding behaviour in two studies was between 3.7 and 6.0%. No differences were found between hoarding and non-hoarding participants with regard to gender, age, marital status, level of education, and employment status. Significant correlations were found between compulsive hoarding and obsessive-compulsive symptoms and also between hoarding and a measure of compulsive buying, even after controlling for anxiety and depressive symptoms. Conclusions: These results indicate that pathological hoarding may also be prevalent in Italy and highlight the need for further epidemiological studies using validated instruments to assess hoarding disorder.
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31

IVANOVA, S. N., L. A. GALASHEVSKAYA y V. O. MARTYNOV. "Clinical manifestations of non-compact left ventricular myocardium". Practical medicine 21, n.º 4 (2023): 132–35. http://dx.doi.org/10.32000/2072-1757-2023-4-132-135.

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The purpose — to present the data of a clinical case of non-compact left ventricular myocardium complicated by severe cardiac arrhythmias and heart failure. Material and methods. The diagnosis of non-compact myocardium of the left ventricle became possible since 1990s after the introduction of echocardiography as a diagnostic method. The disease genesis is still unclear, starting with clinical manifestations of complications: cardiac arrhythmia or heart failure or thromboembolism, leading to fatal outcomes. Conclusions. The article is of interest to practitioners, since non-compact myocardium of the left ventricle is a rare disease, which presumably has both a «family» and a «non-family» character, with the possible occurrence of a triad of syndromes or an asymptomatic course without sufficient evidence for the treatment of this pathology.
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32

Vokes, Everett E. y Mark R. Green. "Clinical Studies in Non-small Cell Lung Cancer: The CALGB Experience". Cancer Investigation 16, n.º 2 (enero de 1998): 72–79. http://dx.doi.org/10.3109/07357909809039760.

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33

Calabrò, Luana, Riccardo Danielli, Luca Sigalotti y Michele Maio. "Clinical Studies With Anti–CTLA-4 Antibodies in Non-melanoma Indications". Seminars in Oncology 37, n.º 5 (octubre de 2010): 460–67. http://dx.doi.org/10.1053/j.seminoncol.2010.09.006.

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34

Hammond, D. W., B. W. Hancock y M. H. Goyns. "Clinical implications of molecular and cytogenetic studies of non-Hodgkin's lymphomas". Cancer Treatment Reviews 24, n.º 2 (abril de 1998): 157–63. http://dx.doi.org/10.1016/s0305-7372(98)90080-9.

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35

Hardy, Russell y Sandra J. Horning. "Molecular Biologic Studies in the Clinical Evaluation of Non-Hodgkin’s Lymphoma". Hematology/Oncology Clinics of North America 5, n.º 5 (octubre de 1991): 891–900. http://dx.doi.org/10.1016/s0889-8588(18)30391-5.

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36

Smith, James D., Padmakumar Narayanan y Nianyu Li. "Biomarkers of platelet dysfunction in non-clinical safety studies and humans". Current Opinion in Toxicology 17 (octubre de 2019): 41–49. http://dx.doi.org/10.1016/j.cotox.2019.11.001.

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37

KAWAURA, Mitsuhiro, Yukio INUYAMA, Masao TOJI, Kazuhito TANAKA, Masato FUJII, Juichi TANAKA, Tetsuro TAKAOKA y Hyounosuke HOSODA. "Clinical Studies on Non-epithelial Malignant Tumors of Head and Neck". Japanese jornal of Head and Neck Cancer 15, n.º 2 (1989): 42–47. http://dx.doi.org/10.5981/jjhnc1974.15.2_42.

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38

Parker, G., G. Tavella, T. Ricciardi y D. Hadzi‐Pavlovic. "Differentiating clinical and non‐clinical depression: a heuristic study offering a template for extension studies". Acta Psychiatrica Scandinavica 141, n.º 4 (5 de diciembre de 2019): 340–49. http://dx.doi.org/10.1111/acps.13130.

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39

Picardi, Angelo, Mauro Pallagrosi, Laura Fonzi, Giovanni Martinotti, Emanuele Caroppo, Giulio Nicolò Meldolesi, Giancarlo Di Gennaro, Marco De Risi y Massimo Biondi. "Attachment in Patients with Bipolar and Unipolar Depression: A Comparison with Clinical and Non-clinical Controls". Clinical Practice & Epidemiology in Mental Health 15, n.º 1 (31 de diciembre de 2019): 143–52. http://dx.doi.org/10.2174/1745017901915010143.

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Background: A link between depression and insecure attachment has long been postulated. Although many studies examined the relationship between depressive symptoms and attachment, relatively few studies were performed on patients diagnosed with depression. Also, research on patients with bipolar disorder is scarce. Objective: We aimed at testing the association between attachment insecurity and unipolar and bipolar depression. Methods: We studied 21 patients with bipolar disorder, current episode depressed, and three age- and sex-matched groups, each consisting of 21 individuals: patients with major depressive disorder, recurrent episode; patients with epilepsy; non-clinical participants. The Experience in Close Relationships questionnaire was used to assess adult attachment style. Results: Patients with both bipolar and unipolar depression displayed significantly higher scores on attachment-related avoidance as compared with patients with epilepsy and non-clinical participants. Also, patients with bipolar depression scored significantly higher on attachment-related anxiety than all other groups. In both psychiatric groups, attachment dimensions were not significantly correlated with global clinical severity or severity of depression. Conclusion: Despite some study limitations, our results are consistent with some previous studies and provide support to Bowlby's seminal hypothesis that attachment insecurity may predispose to depression. Attachment theory may provide a valuable theoretical framework for future research and for guiding treatment.
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40

Ebbehoj, Andreas, Mette Østergaard Thunbo, Ole Emil Andersen, Michala Vilstrup Glindtvad y Adam Hulman. "Transfer learning for non-image data in clinical research: A scoping review". PLOS Digital Health 1, n.º 2 (17 de febrero de 2022): e0000014. http://dx.doi.org/10.1371/journal.pdig.0000014.

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Background Transfer learning is a form of machine learning where a pre-trained model trained on a specific task is reused as a starting point and tailored to another task in a different dataset. While transfer learning has garnered considerable attention in medical image analysis, its use for clinical non-image data is not well studied. Therefore, the objective of this scoping review was to explore the use of transfer learning for non-image data in the clinical literature. Methods and findings We systematically searched medical databases (PubMed, EMBASE, CINAHL) for peer-reviewed clinical studies that used transfer learning on human non-image data. We included 83 studies in the review. More than half of the studies (63%) were published within 12 months of the search. Transfer learning was most often applied to time series data (61%), followed by tabular data (18%), audio (12%) and text (8%). Thirty-three (40%) studies applied an image-based model to non-image data after transforming data into images (e.g. spectrograms). Twenty-nine (35%) studies did not have any authors with a health-related affiliation. Many studies used publicly available datasets (66%) and models (49%), but fewer shared their code (27%). Conclusions In this scoping review, we have described current trends in the use of transfer learning for non-image data in the clinical literature. We found that the use of transfer learning has grown rapidly within the last few years. We have identified studies and demonstrated the potential of transfer learning in clinical research in a wide range of medical specialties. More interdisciplinary collaborations and the wider adaption of reproducible research principles are needed to increase the impact of transfer learning in clinical research.
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41

Murazov, Ia G., M. A. Kovaleva, M. N. Makarova y V. G. Makarov. "Introduction of multicenter design in the non-clinical phase to overcome translational barriers in clinical trials". Translational Medicine 10, n.º 1 (7 de abril de 2023): 52–63. http://dx.doi.org/10.18705/2311-4495-2023-10-1-52-63.

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Background. The translating of individual preclinical studies (PCTs) results into clinical practice is accompanied by a significant number of failures and is associated with significant time and financial costs. The unsatisfactory design of individual non-clinical studies and the reports submitted after having done in vivo experiments at one laboratories do not allow overcoming translational barriers and increasing the results reproducibility. To conduct multicenter non-clinical trials is relevant to to confirm the effectiveness of medicines and increase the chances of successful translation of non-clinical results into clinical practice.Objective. To analyze the scientific literature devoted to multicenter non-clinical studies in the research of the pharmacological activity of new drugs.Design and methods. The research was done using PubMed and Google Scholar databases. The review included available publications as of October 16, 2022.Results. It was discovered that single-center studies did not allow predicting the magnitude of the effect accurately, and large sample sizes made the estimation of the magnitude of the effect even less precise.Conclusions. The main purpose of multicenter non-clinical studies rather should be assessing the direction of the effect, including its “stability”, as well as to identify sources of heterogeneity between studies conducted in different laboratories (centers) than performing a quantitative assessment of the effect on several laboratories, as it tend to be in foreign non-clinical practice.
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42

Nosé, Michela, Corrado Barbui, Richard Gray y Michele Tansella. "Clinical interventions for treatment non-adherence in psychosis: Meta-analysis". British Journal of Psychiatry 183, n.º 3 (septiembre de 2003): 197–206. http://dx.doi.org/10.1192/bjp.183.3.197.

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BackgroundStudies investigating the efficacy of clinical interventions for reducing treatment non-adherence have generated contrasting findings, and treatment non-adherence remains common in clinical practice.AimsTo systematically review whether there are effective clinical interventions that community psychiatric services can implement to reduce non-adherence.MethodSystematic review and metaregression analysis of randomised controlled trials (RCTs) and controlled clinical trials (CCTs) were used to assess the efficacy of interventions to enhance adherence.ResultsWe reviewed 24 studies, more than half of which were RCTs. In 14 studies the experimental intervention was an educational programme. Five studies evaluated pre-discharge educational sessions, three studies explored the benefit of psychotherapeutic interventions and two studies looked at the effect of telephone prompts. The overall estimate of the efficacy of these interventions produced an odds ratio of 2.59 (95% Cl 2.21–3.03) for dichotomous outcomes, and a standardised mean difference of 0.36 (95% Cl 0.06–0.66) for continuous outcomes.ConclusionsCommunity psychiatric services can potentially use effective clinical interventions, backed by scientific evidence, for reducing patient non-adherence.
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43

Sharma, Deepa, Laurentius Oscar Osapoetra y Gregory J. Czarnota. "Implementation of Non-Invasive Quantitative Ultrasound in Clinical Cancer Imaging". Cancers 14, n.º 24 (16 de diciembre de 2022): 6217. http://dx.doi.org/10.3390/cancers14246217.

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Quantitative ultrasound (QUS) is a non-invasive novel technique that allows treatment response monitoring. Studies have shown that QUS backscatter variables strongly correlate with changes observed microscopically. Increases in cell death result in significant alterations in ultrasound backscatter parameters. In particular, the parameters related to scatterer size and scatterer concentration tend to increase in relation to cell death. The use of QUS in monitoring tumor response has been discussed in several preclinical and clinical studies. Most of the preclinical studies have utilized QUS for evaluating cell death response by differentiating between viable cells and dead cells. In addition, clinical studies have incorporated QUS mostly for tissue characterization, including classifying benign versus malignant breast lesions, as well as responder versus non-responder patients. In this review, we highlight some of the important findings of previous preclinical and clinical studies and expand the applicability and therapeutic benefits of QUS in clinical settings. We summarized some recent clinical research advances in ultrasound-based radiomics analysis for monitoring and predicting treatment response and characterizing benign and malignant breast lesions. We also discuss current challenges, limitations, and future prospects of QUS-radiomics.
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44

Nekhaeva, T. L., A. A. Kamaletdinova, M. F. Lutfullin y T. V. Tabanskaya. "Current approaches to quality assessment, non-clinical and clinical studies of dendritic cell vaccines in oncology". Biological Products. Prevention, Diagnosis, Treatment 23, n.º 2 (28 de abril de 2023): 148–61. http://dx.doi.org/10.30895/2221-996x-2023-23-2-148-161.

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At present, personalised cellular immunotherapy is considered a promising approach to the treatment of malignant neoplasms. The effectiveness of these cellular immunotherapy methods is evaluated in the context of clinical and biological tumour characteristics and the state of the immune system of a particular patient. One of the immunotherapy options for cancer is the development of autologous dendritic cell vaccines.The aim of this study was to analyse current methodological approaches to the evaluation of the quality, efficacy, and safety of dendritic cell cancer vaccines.This review describes the functional role of dendritic cells in immune response regulation. The paper presents the results of literature analysis covering current approaches to obtaining dendritic cell vaccines with specific characteristics, quality assessment, studies of the anti-tumour efficacy of cell therapy products, and the experience of conducting non-clinical and clinical studies. The review highlights specific aspects of international experience in the registration and clinical use of cell therapy products. The authors discuss methodological approaches to non-clinical studies of dendritic cell vaccines, which should aim to obtain information to select the dose, route, and mode of administration and to identify immunological markers correlating to the clinical efficacy of cell therapy products. The paper covers international experience in conducting clinical trials of dendritic cell vaccines for various malignant neoplasms. The authors propose a list of quality attributes of human somatic cell-based medicinal products for further clinical use.
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45

Onishi, Akemi, Akifumi Kogame, Yoshihiko Tagawa, Takahiro Kondo y Satoru Asahi. "Evaluation of low background liquid scintillation counter for non-clinical ADME studies". Xenobiotica 43, n.º 6 (21 de diciembre de 2012): 520–26. http://dx.doi.org/10.3109/00498254.2012.744861.

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CHEN, Conrad H. "Non-Clinical Studies of Botanical Medicines as New Drugs-U.S. Regulatory Perspectives". Kampo Medicine 56, n.º 2 (2005): 221–30. http://dx.doi.org/10.3937/kampomed.56.221.

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Adamo, Maria, Louise Pouliot, Stephanie Barbeau, R. Samadfam, A. Varela, I. Primakova, Susan Y. Smith y Keith Robinson. "Assessing postnatal skeletal development in non-clinical reproductive toxicology and pediatric studies". Reproductive Toxicology 30, n.º 2 (septiembre de 2010): 233. http://dx.doi.org/10.1016/j.reprotox.2010.05.047.

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K., Kawaguchi, Sato J., Matsuura M. y Seto K. "Clinical studies of mandibular reconstruction using vascularized and non-vascularized iliac crest". International Journal of Oral and Maxillofacial Surgery 26 (enero de 1997): 213. http://dx.doi.org/10.1016/s0901-5027(97)81472-5.

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SENNA, P., A. DEL BEL CURY y C. RÖSING. "Non-carious cervical lesions and occlusion: a systematic review of clinical studies". Journal of Oral Rehabilitation 39, n.º 6 (21 de marzo de 2012): 450–62. http://dx.doi.org/10.1111/j.1365-2842.2012.02290.x.

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THOMPSON, R., A. MCGHIE, K. MOSER, J. OKEEFE, N. FRITSCH y T. BATEMAN. "Coronary calcium scoring after non-ischemic myocardial perfusion imaging studies, clinical usefulness". Journal of Nuclear Cardiology 12, n.º 2 (marzo de 2005): S37. http://dx.doi.org/10.1016/j.nuclcard.2004.12.263.

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