Tesis sobre el tema "NMR spectroscopy"
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Dücker, Eibe Behrend. "Enhancement Strategies in NMR Spectroscopy". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E3E4-9.
Texto completoStonehouse, Jonathan. "New techniques in NMR spectroscopy". Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360628.
Texto completoHughes, Colan Evan. "New techniques in NMR spectroscopy". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297524.
Texto completoFulwood, Russell. "Chiral analysis by NMR spectroscopy". Thesis, Durham University, 1992. http://etheses.dur.ac.uk/5979/.
Texto completoEdden, Richard Anthony Edward. "New methods in NMR spectroscopy". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613719.
Texto completoZhu, Jian-Ming. "Spatially localized proton NMR correlation spectroscopy". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23681.pdf.
Texto completoNordstierna, Lars. "Molecular Association Studied by NMR Spectroscopy". Doctoral thesis, Stockholm : Physical Chemistry, Department of Chemistry, Royal Institute of Technology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3947.
Texto completoKenwright, A. "Applications of NMR spectroscopy to solids". Thesis, University of East Anglia, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.482971.
Texto completoHa, Dongwan. "Scalable NMR Spectroscopy with Semiconductor Chips". Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11635.
Texto completoEngineering and Applied Sciences
Warne, Mark Anthony. "Theoretical studies in proton NMR spectroscopy". Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321165.
Texto completoSmith, Timothy Andrew David. "Conformational analysis studies in NMR spectroscopy". Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243220.
Texto completoStott, Katherine Mary. "Pulsed field gradients in NMR spectroscopy". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627246.
Texto completoAmero, Carlos D. "Protein Function Study by NMR Spectroscopy". The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1205431343.
Texto completoFauré, De la Barra Nicole Eloísa. "Understanding immobilised enzymes by NMR spectroscopy". Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7319/.
Texto completoKhajeh, Maryam. "Kinetic measurements using time-resolved NMR spectroscopy". Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/kinetic-measurements-using-timeresolved-nmr-spectroscopy(aae85bb3-de19-450a-96ab-50e2dfd89da7).html.
Texto completoKrishnan, Mangala Sunder. "Applications of irreducible spherical tensor operators to NMR and NQR spectroscopy". Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75771.
Texto completoSäwén, Elin. "NMR spectroscopy and MD simulations of carbohydrates". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-61569.
Texto completoBergin, Paul Gerald. "Applications of tritium and tritium NMR spectroscopy". Thesis, University of Surrey, 2002. http://epubs.surrey.ac.uk/842709/.
Texto completoHu, Song 1969. "Thrombin exosite interactions studied by NMR spectroscopy". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23897.
Texto completoVarma, S. C. "Polymer end-group studies using NMR spectroscopy". Thesis, Lancaster University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374665.
Texto completoZagdoun, Alexandre. "Dynamic Nuclear Polarisation Surface Enhanced NMR Spectroscopy". Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2014. http://tel.archives-ouvertes.fr/tel-01065554.
Texto completoEyles, Stephen J. "Studies of protein folding by NMR spectroscopy". Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:06b8fb16-790c-4b72-80d0-8317920655fe.
Texto completoGrieves, R. A. "Multinuclear NMR spectroscopy of transition metal complexes". Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372167.
Texto completoEdgar, Mark. "Studies in proton and flourine NMR spectroscopy". Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240501.
Texto completoCantalapiedra, Nuria Aboitiz. "Intramolecular hydrogen-bonding studies by NMR spectroscopy". Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366715.
Texto completoKraft, Robert A. (Robert Arthur) 1970. "In vivo two-dimensional NMR correlation spectroscopy". Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85271.
Texto completoGao, Chun. "19F DOSY Diffusion NMR Spectroscopy of Fluoropolymers". University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1447069266.
Texto completoRogerson, Alexandria. "New techniques in diffusion-ordered NMR spectroscopy". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/new-techniques-in-diffusionordered-nmr-spectroscopy(aa3eaee0-984b-4434-b460-8c3118a7c3b2).html.
Texto completoInglis, Benjamin Alastair. "In vivo NMR spectroscopy of the brain". Thesis, Queen Mary, University of London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644797.
Texto completoMiletti, Teresa. "Enzyme flexibility studied by solution NMR spectroscopy". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119414.
Texto completoLe lien important entre la dynamique, la structure et la fonction des enzymes n'est pas encore bien défini et est donc une relation intéressante à étudier. Dans cette thèse, les enzymes NADH oxydase (NOX) de Thermus thermophilus et mycobacterium tuberculosis protéine tyrosine phosphatase B (PtpB) sont les systèmes choisis pour étudier l'influence des conditions de solution sur la structure et la flexibilité des protéines par rapport à leur activité catalytique. Les techniques de résonance magnétique nucléaire (RMN) et de calorimétrie de titration isothermique (ITC) ont été utilisées dans l'étude de NOX. La RMN et la fluorimétrie différentielle à balayage (DSF) ont été utilisées pour évaluer la stabilité de l'échantillon de PtpB dans diverses conditions de tampons. NOX est une enzyme homodimérique avec de nombreuses applications biotechnologiques potentielles. NOX accepte les cofacteurs flavine mononucléotide (FMN) ou flavine adénine dinucléotide (FAD). L'enzyme a une stabilité thermique élevée et son activité augmente avec l'addition de faibles concentrations d'urée. Utiliser des enzymes in vitro donne beaucoup de liberté pour contrôler leur environnement, utile pour examiner les changements qui se produisent dans différentes conditions. Ainsi, RMN nous a permis d'étudier ces caractéristiques intéressantes sur la dynamique et la structure de NOX. Lorsque Mtb infecte les cellules, il secrète PtpB qui perturbe les voies de signalisation et affaibli les réponses immunitaires. PtpB contient un couvercle de deux hélices qui enterre complètement le site actif et il est proposé qu'il ait évolué ainsi en protection contre les défenses chimiques et permet un accès au substrat. Une étude de la dynamique du domaine du couvercle de PtpB utilisant la RMN éluciderait la relation entre la conformation et la fonction de PTPB et contribuerait au développement d'inhibiteurs en tant que médicaments potentiels. Pour ceci, il est essentiel d'obtenir un échantillon stable qui donnera des spectres RMN de qualité optimale. RMN et DSF ont été utilisés pour optimiser les conditions d'échantillonnage de PtpB pour la RMN et la qualité spectrale. Nous avons utilisé une suite de nouvelles expériences de relaxation de 15N par RMN pour estimer l'ampleur de l'élargissement des signaux en raison de mouvements à l'échelle de temps des microsecondes et de mesurer les taux de relaxation transversale sans échange pour chaque résidu de NOX. Ces mesures nous ont permis d'identifier plusieurs résidus impliqués dans les processus dynamiques. De plus, les paramètres d'ordre, S2, déterminées à partir des expériences standards de T1, T2 et NOE, ont permis d'identifier des résidus additionnels caractérisés par des mouvements sur des échelles de temps de nanosecondes à picosecondes. Nous avons ensuite étudié les effets de la température, urée, la liaison de cofacteur et du produit à NOX en utilisant la RMN et le ITC. Pour chaque condition étudiée, la variation de déplacement chimique des signaux RMN n'est significative par rapport à tous les autres signaux que pour un petit sous-ensemble récurrent de résidus. Cet amas de résidus est situé autour du site actif de l'enzyme et ainsi, suggère preuve d'une relation entre un réarrangement conformationnel concertée de la structure de NOX et de son activité catalytique. Une augmentation de la qualité spectrale de RMN et un échantillon de PtpB pour la RMN avec une meilleure stabilité thermique, des rendements plus élevés et une agrégation réduite ont été obtenus pour de futures expériences dynamiques par RMN. Ceci a été réalisé en optimisant les conditions de l'échantillon en effectuant plusieurs titrages par RMN et des expériences de DSF. L'évaluation de la stabilité thermique des enzymes avec différents additifs à l'aide de DSF pourrait facilement être introduit lors de l'élaboration de protocoles de purification de protéines comme une méthode routinière pour optimiser les conditions d'échantillons pour les études par RMN.
Le, Guennec Adrien. "Fast 2D NMR spectroscopy for complex mixtures". Palaiseau, Ecole polytechnique, 2015. https://theses.hal.science/tel-01191697/document.
Texto completoMetabolomics is a recent area of research, which aims at analyzing the entirety of molecules involved in chemical reactions in an organism. Nuclear Magnetic Resonance (NMR) is widely used in metabolomics nowadays thanks to a methodology based on one-dimensional (1D) NMR. However, 1D spectra of complex mixtures, like biological extracts or fluids, are characterized by important overlap between peaks, which can be detrimental to the identification and quantification of molecules of interest. Two-dimensional (2D) NMR can be used to reduce the risk of overlap. However, the duration of 2D experiments is often prohibitive for metabolomics studies. Several approaches exist to reduce the duration of 2D experiments, but they have not been evaluated so far for metabolomics. In this thesis, we have shown the usefulness of fast 2D NMR for metabolomics and optimized its performances. Two fast 2D NMR approaches have been evaluated, ultrafast 2D NMR and non-uniform sampling. In a study with synthetic samples, we first demonstrated the usefulness of 2D NMR compared to 1D NMR, then we showed that the experimental time of 2D spectra could be reduced with fast 2D NMR approaches without loss of information. Then we optimized the use of fast 2D NMR for complex mixture analysis. First, we developed a new pulse sequence with ultrafast 2D NMR of proton, in order to suppress the diagonal peaks, which can overlap with correlation peaks and therefore reduce the information content of 2D spectra. Then non-uniform sampling was used to increase up to 32 times the resolution in the indirect dimension without increasing the experimental time and without loss of sensitivity or repeatability. Finally, we worked on automating the determination of relaxation constants in complex mixture. These tools open promising perspectives for high-throughput metabolomics of complex biological samples
Davis, Adrian Lawrence. "Restriction of coherence transfer in NMR experiments". Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239203.
Texto completoBonet, i. Figueredo Roman. "Structural studies on FF domains by NMR spectroscopy". Doctoral thesis, Universitat Autònoma de Barcelona, 2009. http://hdl.handle.net/10803/3609.
Texto completoEn el nostre grup es va començar a estudiar els dominis FF a partir de l'observació que aquests dominis es troben sovint en proteïnes que també contenen WW, un petit domini d'interacció proteïna-proteïna que ha estat i continua sent la línia d'investigació principal del grup, i del qual s'han realitzat nombrosos i detallats estudis.
En canvi, el dominis FF han estat identificats fa poc temps i la informació estructural i funcional de la qual es disposa és, a dia d'avui, escassa. En part, el pocs estudis realitzats amb aquests dominis pot ser conseqüència de que només els trobem en un conjunt reduït de proteïnes. De fet, la seva presència es limita a tres famílies de proteïnes: els factors d'splicing FBP11, Prp40 i URN1, el factor de transcripció CA150 i una família de proteïnes reguladores de RhoGTPases, les p190 RhoGAPs.
Al meu grup, l'estudi amb dominis FF es va iniciar amb la resolució de l'estructura tridimensional del primer FF de la proteïna Prp40 de llevat, que va representar la segona estructura resolta per a un domini FF. En aquest treball l'objectiu ha estat aprofundir en el coneixement dels dominis FF, bàsicament des d'un punt de vista estructural utilitzant com a tècnica principal la resonànica magnètica nuclear (RMN).
Aquesta tesi doctoral s'ha dividit en tres parts i en cada una d'elles s'ha treballat amb els dominis FF de les tres famílies de proteïnes esmentades anteriorment. L'enfoc també ha estat lleugerament diferent a cada part. Així, en el primer capítol, centrat en els dominis FF presents als factors d'splicing URN1 i Prp40, el gruix de la feina va ser l'obtenció de noves estructures tridimensionals per RMN d'aquests dominis. En canvi, en el segon capítol ens vam centrar en l'estudi de la interacció dels dominis FF de CA150 amb el seu primer lligand descrit, un motiu doble fosforilat del domini C-terminal de la RNA-polimerasa II (fosfo-CTD). Finalment, en la tercera part l'interès es va dirigir a l'estudi de la regulació de l'associació dels dominis FF de p190-A RhoGAP amb el factor de transcripció TFII-I, per mitjà d'una fosforilació sobre el primer FF de p190-A RhoGAP.
The present work has been done in the protein NMR group from the Structural and Computational Biology at the IRB Barcelona, under the direction of Dr. Maria J. Macias.
The group's main interest is the structural determination of protein domains, in the study of their interactions and in the understanding of the mechanisms for their regulation. In particular, this work is focused in the structural study of FF domains.
In our group, the study of FF domains began from the observation that these domains are often found in proteins that also contain WW domains, a small protein-protein interaction domain that has been, and continues to be the central research line of the group and that has been object of numerous and detailed studies.
Conversely, FF domains have been recently identified and the structural and functional information available on them is, to date, limited. One of the reasons of the few studies reported for these domains could be consequence of their reduced presence in proteins. In fact, FF domains are only present in three protein families: the splicing factors FBP11, Prp40 and URN1, the transcription factor CA150 and a family of RhoGTPase regulators, the p190 RhoGAPs.
In our group, the work with FF domains started with the solution of the three-dimensional structure of the first FF domain from yeast Prp40, which just represented the second solved structure for an FF domain. In the present work the aim has been to gain insight into FF domain knowledge, basically from a structural point of view, using nuclear magnetic resonance (NMR) as the principal methodology for the structural studies.
This thesis has been divided in three parts, and in each of them we have work with FF domains from the different families mentioned above. The subject of study has been also slightly different in each part. In the first chapter, focused in FF domains present in Prp40 and URN1 splicing factors, the principal work consisted in the obtaining of novel three-dimensional structures for these domains by NMR. In contrast, in the second chapter the main interest was the study of the interaction of CA150 FF domains with their first described ligand, a doubly phosphorylated motif of the RNA polymerase II C-terminal domain (phospho-CTD). Finally, in the last part our efforts were focused in the study of the regulation of p190-A RhoGAP FF domains association with the general transcription factor TFII-I through phosphorylation on the first FF domain of p190-A RhoGAP.
Frise, Anton. "Nano-segregated soft materials observed by NMR spectroscopy". Doctoral thesis, KTH, Fysikalisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-30337.
Texto completoQC 20110225
Koskela, H. (Harri). "Some aspects of polarisation transfer in NMR spectroscopy". Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277988.
Texto completoTalagala, Sardha Lalith. "Aspects of NMR imaging and in vivo spectroscopy". Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/27550.
Texto completoScience, Faculty of
Chemistry, Department of
Graduate
Khan, Amjad. "NMR spectroscopy studies of enzyme function and inhibition". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:698d69c7-d4f1-4bc7-bf0b-3b9e7fb3a4fe.
Texto completoFeng, Xiaolong. "Estimating molecular conformations by solid-state NMR spectroscopy /". Stockholm : Eigenverl, 1998. http://www.gbv.de/dms/goettingen/265942721.pdf.
Texto completoGlaubitz, Clemens. "Magic angle sample spinning NMR spectroscopy on biomembranes". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267922.
Texto completoDowell, Nicholas G. "Further developments in high-resolution quadrupolar NMR spectroscopy". Thesis, University of Exeter, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407274.
Texto completoLesperance, Leann M. (Leann Marie). "Compositional studies of cartilage matrix using NMR spectroscopy". Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/17331.
Texto completoIncludes bibliographical references (leaves 142-150).
by Leann Marie Lesperance.
Ph.D.
Orr, Robin Macnab. "Measuring anisotropic interactions using solid-state NMR spectroscopy". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612898.
Texto completoOdedra, Smita. "Some novel developments in high-resolution NMR spectroscopy". Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5772/.
Texto completoZhu, Xu Carleton University Dissertation Chemistry. "129Xe NMR spectroscopy of xenon in coal micropores". Ottawa, 1994.
Buscar texto completoAsami, Sam. "Method development for biomolecular solid-state NMR spectroscopy". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/17044.
Texto completoIn this thesis, a novel labeling scheme for solid-state NMR spectroscopy, the Reduced Adjoining Protonation (RAP) scheme, is introduced, which allows proton detection of all aliphatic sites, as shown for the microcrystalline SH3 domain of alpha-spectrin. These samples yield high-resolution, 1H-detected 1H,13C correlation spectra. In addition, the benefit of high MAS frequencies was investigated. 1H- and 13C-detected 3D assignment experiments are implemented, which allowed us to assign 90% of all aliphatic resonances of alpha-spectrin SH3. As the chemical shift is dependent on the structural motif, it can be employed to derive secondary structure information. Furthermore, a 1H-detected H(H)CH 3D experiment is introduced, to obtain long-range 1H,1H contacts, which can be used for the determination of the tertiary structure. To obtain artifact-free relaxation data, the RAP labeling scheme was modified to obtain sparsely proton labeled, 13C dilute samples, in which spin diffusion is suppressed. To probe sub-microsecond dynamics, we report experiments to determine 13C T1 relaxation times and 1H,13C dipolar coupling tensors for backbone and side chain resonances, respectively. Furthermore, we show, that the RAP labeling scheme can be applied to non-crystalline systems, such as amyloid fibrils of the Alzheimer’s disease peptide Abeta1-40. Using 1H-detection, we obtained high-resolution 1H,13C correlation spectra. Finally, we applied the perdeuteration approach to the L7Ae-box C/D protein-RNA complex from P. furiosus. We obtained high-resolution, 1H-detected 1H,15N, as well as 13C,13C correlation spectra of the protein-RNA complex. In addition, we established a methodology to determine accurate distance and angular restraints for the protein-RNA interface and propose approaches for the chemical shift assignment of RNA resonances.
Wu, Xi-Li. "New techniques in nuclear magnetic resonance spectroscopy". Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385872.
Texto completoLucena, Alcalde Guillermo. "New developments in chromatographic NMR". Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/76636/.
Texto completoDvoyashkina, Nina, Dieter Freude, Christopher F. Seidler, Michael Wark y Jürgen Haase. "Composite fuel cell materials studied by MAS PFG NMR diffusometry and MAS NMR spectroscopy". Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-198097.
Texto completoDvoyashkina, Nina, Dieter Freude, Christopher F. Seidler, Michael Wark y Jürgen Haase. "Composite fuel cell materials studied by MAS PFG NMR diffusometry and MAS NMR spectroscopy". Diffusion fundamentals 24 (2015) 12, S. 1, 2015. https://ul.qucosa.de/id/qucosa%3A14526.
Texto completoBrough, Adrian R. "Solid state NMR studies of inorganic materials". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239312.
Texto completo