Tesis sobre el tema "Nanoparticle injection"
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Rust, Michael J. "Mass-Producible Nanotechnologies Using Polymer Nanoinjection Molding: Nanoparticle Assemblies, Nanoelectrodes, and Nanobiosensors". University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242931328.
Texto completoKrüger, Susanne [Verfasser], Alexander [Akademischer Betreuer] Eychmüller y Michael [Akademischer Betreuer] Wark. "Characterisation of a PbS Nanoparticle sensitized Injection Solar Cell by means of Electrochemical and Frequency-modulated Methods / Susanne Krüger. Gutachter: Alexander Eychmüller ; Michael Wark. Betreuer: Alexander Eychmüller". Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://d-nb.info/1068442751/34.
Texto completoRességuier, Julien. "Étude de la biodistribution de nanoparticules de poly(acide lactique) chez le poisson-zèbre après administration muqueuse et intraveineuse". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1023/document.
Texto completoMedecine shows a growing interest regarding nanobiotechnologies. Among them are poly(lactic acid) (PLA) nanoparticles, which represent a biocompatible and competent nanosystem to heighten the specificity and efficacy of diverse therapeutic and vaccine treatments, following mucosal and intravenous administration. However, the further optimization of such nanosystem is poised by the lack of informations regarding their in vivo biodistribution, especially at the cellular level.The main objective of this PhD is to increment the knowledge about PLA nanoparticles biodistribution in vivo, after muquous and intravenous administration, to further expand their optimisation and use perspectives. The zebrafish model has been utilized to perform this research because of his conserved complexity as well as his suitability for whole-organism studies.To fulfill this project, a precise methodology has been developed to analyze the PLA nanoparticles biodistribution. Which allowed, after bathing administriation, to unveil their robust innate tropism toward mucous dendritic cells. From these data has been established a targeting strategy, utilizing the peanut agglutinin lectin, which has been proved to enhance nanoparticle uptakes by both gills and skin mucosae. Finally, the study of PLA nanoparticles behavior and destiny after intravenous injection, revealed numerous elaborated interactions with the circulatory system.Overall, this work has been able to strengthen our understandings of PLA nanoparticles among living organisms, furthermore highlighting their promizing potential as nanovehicles for mucosal vaccines
Jiang, Pengfei. "Sustained Delivery of Anti-VEGF for Treating Wet Age-related Macular Degeneration". The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1594995217778125.
Texto completoVerry, Camille. "Traitement des métastases cérébrales par radiothérapie et nanoparticule de gadolinium : du modèle pré clinique à l'utilisation chez l'homme Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase 1 study protocol First in man injection of gadolinium-chelated based nanoparticle (AGuIX®) as theranostic agent for treatment of multiple brain metastases by adiotherapy: a case report". Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS029.
Texto completoThe occurrence of multiple brain metastases is a critical evolution of many cancers with a major impact on overall survival. A new gadolinium-based nanoparticle, AGuIX®, has recently demonstrated its efficacy as a radiosensitizer and MRI contrast agent in several preclinical studies. The objective of this thesis is to establish a proof of concept on an animal model and then to perform the first administration of this new drug in humans in a phase 1 trial. The first part of this work consisted of a 6 MeV irradiation after AGuIX® injection of a Fisher rat model carrying 9L cerebral gliomas assessed by MRI. A favorable distribution of nanoparticles was observed by EPR effect (Enhanced Permeability and Retention) with a concentration of gadolinium into the tumor 20 times higher than in healthy brain. The radiosensitizing effect was demonstrated with a significant decrease in tumor size (p=0.02) for the irradiated group with AGuIX® injection. These results, combined with the favorable safety profile in animal models, motivated the transfer of this new drug to humans in a Phase 1 study named NANO-RAD (EudraCT2015-004259-30; NCT02820454). This is a monocentric, open-label study evaluating the feasibility and safety of AGuIX® combined with whole brain radiation therapy (30 Gy, 10 Fr of 3 Gy) for patients with multiple brain metastases. The main objective is to determine the maximum tolerated dose of nanoparticles with a dose escalation scheme by steps of 3 patients at 15, 30, 50, 75 and 100 mg/kg. Secondary objectives are the pharmacokinetics, distribution of AGuIX® by MRI, intracranial progression-free survival and overall survival. The first human administration was performed at Grenoble University Hospital on 18 July 2016 and the last patient (n=15) was included on 06 February 2018. All metastases, whatever the histological type (lung, melanoma, breast) had a uptake of AGuIX® whose concentration in the tumor was proportional to the injected dose. The average blood half-life is 1h09 (± 26 min). Tolerance to the treatment was good with a dose escalation up to 100 mg/kg, which became the dose selected for further clinical trials. Of the 14 evaluable patients, 12 had a clinical benefit of treatment with a decrease in tumor volume. These preliminary results are promising in terms of safety, distribution and efficacy and should be confirmed by the randomized multicenter Phase 2 study planned for the end of 2018
Fallahi, Fahimeh. "Bioaccumulation and Neuroinflammation of GoldNanoparticles in the Central Nervous System". Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1369756360.
Texto completoKrüger, Susanne. "Analyse einer mit PbS-Nanopartikeln sensibilisierten Injektionssolarzelle mittels elektrochemischer und frequenzmodulierter Verfahren". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-85503.
Texto completoBourrinet, Philippe. "Etude de la cinétique sanguine et plasmatique, de la distribution tissulaire et de l'élimination des nanoparticules de méthylidène malonate 2. 1. 2 administrées par voie intraveineuse chez le rat". Paris 5, 1992. http://www.theses.fr/1992PA05P163.
Texto completoKroschwald, Felix. "Prozessintegrierter Transfer von Nanopartikeln auf Polycarbonatoberflächen beim Spritzgießen". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-202485.
Texto completoMikheenko, I., P. Mikheenko, P. Jenkins, G. A. Attard, L. E. Macaskie y T. H. Johansen. "Visualization of Spin Polarized States in Biologically-Produced Ensembles of Ferromagnetic Palladium Nanoparticles". Thesis, Sumy State University, 2012. http://essuir.sumdu.edu.ua/handle/123456789/35337.
Texto completoPape, Elise. "Intérêt de la Rapamycine en Pharmacologie et en Ingénierie articulaires". Thesis, Université de Lorraine, 2021. http://www.theses.fr/2021LORR0290.
Texto completoRapamycin is an mTOR inhibitor currently used as an immunosuppressant, particularly in the field of transplantation. It inhibits the mTOR signaling pathway leading to the restoration of autophagy, a process that is deficient in the pathophysiology of osteoarthritis, making its use interesting in the treatment of degenerative arthropathies. However, rapamycin is responsible for significant systemic adverse drug reactions. To reduce this risk, its local injection, within the joint, is an advantageous alternative. Nevertheless, this route of administration has disadvantages: direct contact of the joint tissue with high concentrations of active drug, its clearance from the joint cavity, and the difficulty of administering such a hydrophobic compound. Therefore, the development of nanoparticles is an attractive alternative to improve its use by intra-articular application. In this work, we evaluated the cytotoxicity of rapamycin on joint cells, namely chondrocytes and synoviocytes at different concentrations and different times. We observed a dose-dependent cytotoxicity, and a higher sensitivity of synoviocytes compared to chondrocytes. Cytotoxicity on bone mesenchymal stem cells, which are used in cartilage engineering, also showed dose-dependent toxicity. Rapamycin at 10 µM, described as delaying cartilage damage in experimental osteoarthritis, does not induce toxicity and reduces the catabolic effect of IL-1ß-induced MMP13 on chondrocytes and synoviocytes. In this study, PLGA nanoparticles were developed to release rapamycin in a sustained manner after intra-articular administration at this concentration. Free and rapamycin-loaded nanoparticles were not responsible for cytotoxicity on chondrocytes, synoviocytes. Finally, we found in vivo that administration of 50 µL of 10 µM rapamycin-loaded nanoparticle intra-articularly in rats increased its half-life and mean retention time in the joint, compared to local administration of the free form, while decreasing its systemic diffusion
Waurisch, Christian. "Thermodynamic and kinetic investigations into the syntheses of CdSe and CdTe nanoparticles". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-91768.
Texto completoNarvekar, Priya P. "Axitinib Loaded PLGA nanoparticles for Age-Related Macular Degeneration". Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7866.
Texto completoEslahpazir, Esfandabadi Roham. "Synthèse de nanoparticules de carbure de fer dans un réacteur à plasma inductif". Mémoire, Université de Sherbrooke, 2009. http://savoirs.usherbrooke.ca/handle/11143/1454.
Texto completoYang, Yiqun. "Integration of photosynthetic pigment-protein complexes in dye sensitized solar cells towards plasmonic-enhanced biophotovoltaics". Diss., Kansas State University, 2016. http://hdl.handle.net/2097/32857.
Texto completoDepartment of Chemistry
Jun Li
Solar energy as a sustainable resource is a promising alternative to fossil fuels to solve the tremendous global energy crisis. Development of three generation of solar cells has promoted the best sunlight to electricity conversion efficiency above 40%. However, the most efficient solar cells rely on expensive nonsustainable raw materials in device fabrication. There is a trend to develop cost-effective biophotovoltaics that combines natural photosynthetic systems into artificial energy conversion devices such as dye sensitized solar cells (DSSCs). In this research, a model system employs natural extract light-harvesting complex II (LHCII) as a light-absorbing sensitizer to interface with semiconductive TiO₂ and plasmonic nanoparticles in DSSCs. The goal of this research is to understand the fundamental photon capture, energy transfer and charge separation processes of photosynthetic pigment-protein complexes along with improving biophotovoltaic performance based on this model system through tailoring engineering of TiO₂ nanostructures, attaching of the complexes, and incorporating plasmonic enhancement. The first study reports a novel approach to linking the spectroscopic properties of nanostructured LHCII with the photovoltaic performance of LHCII-sensitized solar cells (LSSCs). The aggregation allowed reorganization between individual trimers which dramatically increased the photocurrent, correlating well with the formation of charge-transfer (CT) states observed by absorption and fluorescence spectroscopy. The assembled solar cells demonstrated remarkable stability in both aqueous buffer and acetonitrile electrolytes over 30 days after LHCII being electrostatically immobilized on amine-functionalized TiO₂ surface. The motivation of the second study is to get insights into the plasmonic effects on the nature of energy/charge transfer processes at the interface of photosynthetic protein complexes and artificial photovoltaic materials. Three types of core-shell (metal@TiO₂) plasmonic nanoparticles (PNPs) were conjugated with LHCII trimers to form hybrid systems and incorporated into a DSSC platform built on a unique open three-dimensional (3D) photoanode consisting of TiO₂ nanotrees. Enhanced photon harvesting capability, more efficient energy transfer and charge separation at the LHCII/TiO₂ interface were confirmed in the LHCII-PNP hybrids, as revealed by spectroscopic and photovoltaic measurements, demonstrating that interfacing photosynthesis systems with specific artificial materials is a promising approach for high-performance biosolar cells. Furthermore, the final study reveals the mechanism of hot electron injection by employing a mesoporous core-shell (Au@TiO₂) network as a bridge material on a micro-gap electrode to conduct electricity under illumination and comparing the photoconductance to the photovolatic properties of the same material as photoanodes in DSSCs. Based on the correlation of the enhancements in photoconductance and photovoltaics, the contribution of hot electrons was deconvoluted from the plasmonic near-field effects.
Palleau, Etienne. "Assemblage électrostatique dirigé de nanoparticules colloïdales sur des surfaces par nanoxérographie par microscopie à force atomique". Thesis, Toulouse, INSA, 2011. http://www.theses.fr/2011ISAT0013/document.
Texto completoThe study of original properties of colloidal nanoparticles and their integration into nanodevices requires their assembly onto specific areas of solid surfaces. The aim of this thesis work is to develop an innovative method for the directed assembly of colloidal nanoparticles: the nanoxerography process by atomic force microscope (AFM). This technique consists in injecting charges into electrets using an AFM tip. The injected charges are then used to electrostatically trap nanoparticles from suspensions onto the surface. In this context, the charge writing and charge decay in PolyMethyMethAcrylate (PMMA) thin films were studied and the charge density of the charged patterns were quantified using Kelvin force microscope (KFM), an electrical mode of AFM. Assemblies of nanoparticles of different nature (metallic, polymeric (organic and inorganic)), with average sizes extending over a large range (2 nm to 1 µm) and controlled zeta potential were obtained on PMMA thin films. This allowed the analysis of assembly mechanisms and demonstration of the excellent performance of the method. Finally, two techniques of parallel charge writing, viz., the electrical microcontact printing and the electrical nanoimprinting were explored with the prospect of extending the nanoxerography process to industrial scale
Gestraud, Cecilia. "Synthèse, fonctionnalisation et assemblage de nanodisques d'argent". Thesis, Toulouse, INPT, 2019. http://www.theses.fr/2019INPT0112.
Texto completoSilver nanoparticles, used extensively in catalysis, optics and electronics, are now emerging in new applications such as imaging, photonics or chemical and biochemical detection. Among these applications, some require particular morphologies such as rods or disks (conductive films, enhanced Raman spectroscopy) while others mainly involve a large specific surface area such as in heterogeneous catalysis. Anisotropic metal nanoparticles are traditionally produced in two stages, separating the formation of seeds and their growth, in order to better control their morphology. However, the two-stage synthesis makes the transfer on industrial scale difficult because of the long incubation time and the washing steps required. In this context, we decided to focus on the synthesis of anisotropic nanoparticles, in particular silver nanodisks, as well as their assembly in solution and on surfaces. In our work, we adopted an approach that allows to carry out the two stages of the formation of silver nanodisks in the same reaction medium. The principle is based on the use of two reducers, one weak and one strong, with different kinetic reduction rates, allowing the control of anisotropy. This method is simple and fast but requires good control of the experimental parameters. The time between the addition of the two reducers determines the morphology of the formed objects. There is actually an optimal range for this time, which depends particularly on the temperature of the synthesis. In order to vary the optical properties of these nanodisks, different strategies can be considered. We chose to form assemblies both in solution and on surfaces by different deposition techniques. The adsorption of bifunctional organic molecules can provoke the formation of assemblies in solution: one function has an affinity with silver and the other interacts with the free functions of the other nanoparticles through hydrogen or electrostatic bonds for example. Assemblies can also be made on surfaces. We have been working on original deposition method, which allow an oriented assembly of nanodisks through electrostatic forces.We have demonstrated that these assemblies are good candidates for developing micro-structured SERS substrates
Bjørnerud, Atle. "Proton Relaxation Properties of a Particulate Iron Oxide MR Contrast Agent in Different Tissue Systems : Implications for Imaging". Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2150.
Texto completoKnowledge of the relationship between in vivo contrast agent concentration and magnetic resonance (MR) signal response is an important requirement in contrast enhanced MR imaging in general and in MR based perfusion imaging in particular. This relationship is a complex function of the properties of the contrast agent as well as the structure of the target tissue. The aim of the present work was to quantify the effects of the iron oxide nanoparticle based intravascular contrast agent, NC100150 Injection, on proton relaxation rates in different tissue systems in vivo in a pig model and ex vivo in phantoms containing whole blood. Methods that enabled accurate relaxation rate measurements in these organs were developed, and validated. From these measurements, trans-compartmental water exchange rates and blood volume could be estimated and the MR signal response could be predicted as a function of contrast agent concentration under relevant imaging conditions.
Using a 1.5 Tesla clinical MR system, the longitudinal (R1=1/T1) proton relaxation rates in blood, renal cortex, paraspinal muscle and myocardium were measured in vivo as a function of plasma concentration (Cp) of NC100150 Injection. The transverse (R2* = 1/T2*) relaxation rates were measured in vivo in blood, renal cortex and muscle as a function of Cp and ex vivo in blood as a function of Cp and blood oxygenation tension. The proton nuclear MR (NMR) linewidth and lineshape were analysed as a function of Cp and blood oxygen tension ex vivo at 7.05 T.
In muscle and renal cortex, there was a linear correlation between R2* and Cp whereas R2* increased as a quadratic function of Cp in blood. The NMR linewidth increased linearly with Cp in fully oxygenated blood whereas in deoxygenated blood the linewidth initially decreased with increasing Cp, reaching a minimum and then increasing again with further increase in Cp. R1 increased linearly with Cp in blood and from the slope of R1 vs. Cp the T1-relaxivity (r1) of NC100150 Injection in blood at 1.5 T was estimated to be (mean ± SD) 13.9 ± 0.9 s-1mM-1. In tissue, the maximum increase in R1 was limited by the rate of water exchange between the intravascular and interstitial tissue compartments. Using a two-compartment exchange-limited relaxation model, the permeability surface area (PS) product was estimated to be 61.9 ± 2.9 mL/min/g in renal cortex and 10.1 ± 1.5 mL/min/g in muscle and the total myocardial water exchange rate, kt, was 13.5 ± 6.4 s-1. The estimated blood volumes obtained from the same model were 19.1 ± 1.4 mL/100 g, 2.4 ± 1.4 mL/100 g and 11.2 ± 2.1 mL/100 g, respectively in renal cortex, muscle and myocardium.
Current T2* based first-pass MR perfusion methods assume a linear correlation between R2* and Cp both in blood and tissue and our results therefore suggest that quantitative perfusion values can not easily be obtained with existing tracer kinetic models. The correlation between MR signal response and Cp is further complicated in the kidney by a significant first-pass increase in R1 which may lead to an underestimation of Cp. In T1-based perfusion methods, low concentrations of NC100150 Injection must be used in order to maintain a linear dose-response relationship between R1 and Cp. The effect of blood oxygenation on the NMR linewidth in the presence of NC100150 Injection enabled accurate estimation of magnetic susceptibility of deoxyhemoglobin and the effect can potentially be used to determine blood oxygenation status.
In conclusion, NC100150 Injection is well suited as a T2* perfusion agent due to the large magnetisation and intravascular biodistribution of this agent. T1-based perfusion imaging with this agent is limited by water exchange effects and large T2* effects at higher contrast agent concentrations. Quantitative perfusion assessment is unlikely to be feasible with any of these approaches due to the non-linear dose response.
Fortage, Jérôme. "Synthèses et caractérisations d'édifices bisporphyriniques pour la séparation photo-induite de charges : sensibilisation par photo-injection de lacunes électroniques dans des nanoparticules d'oxyde de nickel par des pérylènes imides". Nantes, 2006. http://www.theses.fr/2006NANT2137.
Texto completoThis work deals with photo-induced intramolecular charge separation in bisporphyrinic systems and with the sensitization of p-type semi-conductor for photovoltaic. The first section concerns the synthesis of dyads containing an electron donor and an acceptor connected with a long -conjugated spacer. In these dyads, the donor can be a zinc porphyrin or zinc phthalocyanine and the acceptor can be a gold porphyrin or tin porphyrin. These electronically coupled donor-acceptor systems perform single step a long-range photo-induced electron transfer over nanometer scale. The photophysical study reveals a very fast charge separation and a slower back recombinaison. In the second section, new sensitizers based on perylene unit were grafted on the nickel oxide nanoparticules. The light excitation of sensitizer induces a fast hole injection into the semi-conductor’s valence band. The solar cells based on the sensitization of nickel oxide exhibit promising photovoltaic performances
Caruyer, Céline. "Modélisation de nanomatériaux injectés par voie liquide dans un jet de plasma pour la fabrication de nanostructures". Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14329/document.
Texto completoThe study of the plasma spraying process is investigated in this work, in particular the interaction between a liquid phase and a plasma flow. Different physical phenomena occureas the jet fragmentation, the liquid vaporization and the particles fusion. The numerical simulation is used to better understand the physical phenomena and is an alternative to experimental measurements, which could be locally difficult to perform because of the measurement techniques limitations and the particular characteristics of the plasma. A compressible two-phase model is developped to take into account the compressible effects of the plasma flow. Validations are realized on academic test cases and on a argonjet. Good agreements are obtained between simulations and theory or experiments. Then different mixtures of plasmagen gas, classically used in plasma spraying, are studied :argon/hydrogen and argon/helium. An analysis of unsteady and turbulent character isled and allows seeing the importance of unsteady effects in these flows. Numerical simulations of the injection of a liquid phase into the plasma flow are realized. The influence of the plasmagen gas nature and the injection type is anlysed. Structures observed by experiments are also obtained by the simulations
Freitas, Luiz Guilherme Azevedo de. "Avaliação das alterações retinianas em olhos de coelho após injeções intravítrea de sunitinibe, nanopartículas lipídicas sólidas e nanocápsulas". Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5446.
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To evaluate the safety of single intravitreal injection of 0,1ml of sunitinib (one group with 1mg/ml and the other group with 10mg/ml), 0,1ml of a solution containing solid lipid nanoparticles and 0,1ml of a solution containing nanocapsules analyzing the possible toxic effects by the electrophysiology and histology in the albino rabbits retina. An experimental controlled study was performed with 20 eyes of albino rabbits. It were performed intravitreal injections of 0,1ml (1mg/ml) of sunitinib in 5 eyes, 0,1ml (10mg/ml) of sunitinib in 5 eyes, 0,1ml of nanocapsules solution in 5 eyes and 0,1ml of a solution containing solid lipid nanoparticles in 5 eyes. Contralateral eye did not receive any treatment and was used as control. Changes in electroretinography were not observed in groups of sunitinib (1mg/ml and 10mg/ml) and in the group of solid lipid nanoparticles. However, in the group of the nanocapsules significant changes were found. They were in the morphology and at the electroretinogram. At histological study only the group of nanocapsules degenerative changes were detected. Changes were severe edema and formation of cytoplasmic vacuoles, suggesting retinal toxicity.
O presente estudo teve por objetivo avaliar a segurança da injeção intravítrea de 0,1ml de sunitinibe (um grupo com 1mg/ml e o outro grupo com 10mg/ml), 0,1ml de solução contendo nanocápsulas e 0,1ml de solução contendo nanopartículas lipídicas sólidas analisando os possíveis efeitos tóxicos à retina de coelhos albinos detectados pela eletrofisiologia e histologia por microscopia óptica. Foi realizado estudo experimental, com 20 olhos de coelhos albinos, nos quais foram realizadas injeções intravítreas de 0,1ml (1mg/ml) de sunitinibe (5 olhos), 0,1ml (10mg/ml) de sunitinibe (5 olhos), 0,1ml de solução contendo nanocápsulas (5 olhos) e 0,1ml de solução contendo nanopartículas lipídicas sólidas (5 olhos). Os olhos adelfos não receberam injeção e foram utilizados com o controle. Não foram observadas alterações eletrorretinográficas nos grupos do sunitinibe (1mg/ml e 10mg/ml) e no grupo das nanopartículas lipídicas sólidas. No grupo das nanocápsulas houveram alterações significativas tanto na morfologia quanto na amplitude e tempo das ondas do eletrorretinograma. Ao estudo histológico, somente o grupo das nanocápsulas apresentou alterações degenerativas (núcleos tumefeitos) com acentuado edema e formação de vacúolos citoplasmáticos, sugerindo toxidade retiniana.
Correa, Anabel Laza. "Desenvolvimento de sensores utilizando hidróxidos metálicos mistos nanoestruturados e sua aplicação em sistemas BIA". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-26042018-141249/.
Texto completoMartins, Paulo Roberto. "Preparação de hidróxidos mistos nanoestruturados de níquel/cobalto e desenvolvimento de sensores FIA amperométricos". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-06092012-093005/.
Texto completoNew nanomaterials based on mixed nickel and cobalt hydroxides stabilized in the alpha phase, as well as amperometric sensors based on supramolecular porphyrins and stabilized alpha nickel hydroxide were developed in this thesis. An amperometric FIA sulfite analyzer was also developed in colaboration with of Group of Analytical Instrumentation of IQ-USP, for determination of free SO2 present in liquid samples such as wine, coconut water and fruit juices. The amperometric FIA system is constituted by manual injector, amperometric FIA cell with integrated gas diffusion unit and amperometric sensor based on supramolecular porphyrins, whereas sulfuric acid and electrolyte were used as reactive and carrier solution. Some species such as ascorbic acid, cathecol, glucose and sodium benzoate were evaluated as possible interferents before starting the analyses of real samples. The results were compared with those obtained with the official Monier-Williams method. The concentrations of free SO2 found in fruit juices and coconut water were in accordance with Brazilian law. The amperometric FIA sensors for determination of glucose were based on FTO electrodes modified stabilized alpha nickel hydroxide, which presented excellent linear responses at concentrations below 100 µM. These sensors have shown a very high specific sensitivity for glucose probably associated with their nanostructured nature, and consequent enhanced surface area. Nevertheless, the electrode material was shown to have an increasing tendency to change from alpha to the beta phase as function of the glucose concentration. New materials based on mixed nickel and cobalt hydroxides, stabilized in the alpha phase was prepared and characterized by techniques such as X-ray diffraction, thermogravimetric analysis and Electrochemical Quartz Crystal Microbalance to determine their polymorphic phase. The nanostructured nature of the mixed nickel and cobalt hydroxide materials was confirmed by microscopy techniques such as AFM and SEM. These new materials showed a high specific charge, in fact higher than of nanostructured stabilized alpha nickel hydroxide. An amperometric FIA sulfite analyzer system for liquid samples consisting of solution reservoirs, a sampling system, a solution propulsion system, an amperometric FIA cell with integrated gas diffusion unit, an amperometric sensor based on supramolecular porphyrins, in addition to controller boards, a mini-potentiostat and control software, was developed and tested for determination of free SO2. High reproducibility was achieved for sequential analyses of a sample but the reproducibility after exchange of samples was relatively low, needing further developments in the sampling system.
Rankin, Kelli Margaret. "Novel solvent injection and conformance control technologies for fractured viscous oil reservoirs". Thesis, 2013. http://hdl.handle.net/2152/24793.
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Ho, Cheng-Yu y 何承育. "Spin injection from Ni thin film and Fe3O4 nanoparticle into InGaN/GaN nanorod light-emitting diode". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/68035608835385142199.
Texto completo國立臺灣大學
應用物理所
100
The motivation of this thesis is to compare the performance of the degree of circularly polarized light between conventional thin film spin-LED and nanorod spin-LED. In our experiment, we compare the degree of circularly polarized light for the thin film and nanorod spin-LEDs, which is composed of InGaN/GaN multiple quantum wells, under an external magnetic field by photoluminescence and electroluminescence. We also deposit the Fe3O4 nanoparticles into the space between nanorods in order to enhance the degree of circularly polarized light arising from nanorod spin-LED. The quantum confined stark effect will gradually vanish and confined potential will become more symmetric as the thin film multiple quantum wells are etched into the nanorod structure. Thus the spin coherent time will become longer in quantum well. In addition, the efficiency of spin valve will increase after the deposition of Fe3O4 nanoparticles. Due to the increment for both the spin coherence time and efficiency of spin valve, our results show that the degree of circularly polarized light of the nanorod spin-LED with Fe3O4 nanoparticles under low external magnetic field and room temperature can be more than 10%. Its excellence performance and practical working condition make nanorod spin-LED becomes a potential spin device.
Hsu, Ting Kang y 許庭綱. "Investigation of graphene-nanoparticle nanocomposites and graphene nanoribbons on screen-printed electrodes using flow injection system for biosensor applications". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/14782044696173773535.
Texto completo長庚大學
化工與材料工程學系
100
The screen printing electrode (SPE) has been of great interests recently. In this study, we use the SPE with the help of a flow injection system to study the effects of nanomaterials on biosensing. In the first part of our study, graphene nanoribbons are used for the electrochemical detection of ascorbic acid, dopamine and uric acid. In the second part of our study, the optimized copper oxide/graphene nanocomposites are applied for sensing of glucose. In comparison with traditional electrochemical measurements, we found that the better results can be obtained in terms of the coefficient of the sensitivity and detection limit. Therefore, it is crucial to develop a high-performance and lost cost biosensor system based on SPE.
Qiu, Fangda. "Experimental Study of Solvent Based Emulsion Injection to Enhance Heavy Oil Recovery". Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-05-7952.
Texto completoKroschwald, Felix. "Prozessintegrierter Transfer von Nanopartikeln auf Polycarbonatoberflächen beim Spritzgießen". Doctoral thesis, 2015. https://tud.qucosa.de/id/qucosa%3A29492.
Texto completo黃柏軒. "Characterizations of CuInS2 Nanoparticles and Its Thin Films Prepared by Hot-Injection Method". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/36027528756024872459.
Texto completo國立交通大學
材料科學與工程學系
100
CuInS2 nanoparticles were prepared by injecting the sulfur which had been dissolved in the oleylamine (S-OLA) into the hot oleylamine solution containing copper(I) chloride (CuCl) and indium(III) chloride (InCl3). By adjusting the reactive temperature and time of hot-injection process, CuInS2 nanoparticles about 10 nm in size were successfully formed at 180?aC for 1 hr. X-ray diffraction analysis revealed that the wurtzite phase is suppressed by decreasing the reactive temperature and the crystallinity of chalcopyrite phase improves with the increase of reactive time. The CuInS2 nanoparticles were consequently dispersed in toluene to form the ink for preparing the CuInS2 thin films on the glass subatrate via the dipping-coating process. It was found that the CuInS2 content of ink is crucial to the film quality. Moreover, the incorporation of cyclohexanone was found to improve the wetting property of ink on glass subatrate, which benefits the preparation of uniform and crack-free CuInS2 films. Post annealing study indicates the heat treatments in Ar or vacuum ambient result in the formation of In2O3 phase in thin-film samples and the annealing in Ar+10%H2 ambient is able to eliminate such an undesired oxide phae in CuInS2 thin films. However, further study is required since the carrier concentration of CuInS2 film was still high and impratical for solar cell device fabrication.
Krüger, Susanne. "Analyse einer mit PbS-Nanopartikeln sensibilisierten Injektionssolarzelle mittels elektrochemischer und frequenzmodulierter Verfahren". Doctoral thesis, 2011. https://tud.qucosa.de/id/qucosa%3A25950.
Texto completoHuang, Mao-Cheng y 黃茂誠. "Study on the growth mechanism of high quality Cu2ZnSnS4 nanoparticles synthesized by hot injection method". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/14492182797813808088.
Texto completo國立清華大學
材料科學工程學系
101
The highest efficiency Cu(In,Ga)Se2(CIGS) thin film solar cells have reached 20%. However, the indium and gallium are rare elements in the crust. A promising quaternary semiconductor Cu2ZnSnS4(CZTS) has been proposed to replace CIGS. CZTS is composed of four earth abundant elements, and has some advantages such as high absorption coefficient, direct band gap of 1.5eV, and nontoxic material. The highest CZTS device was fabricated by the solution based hydrazine process. However, hydrazine is a vary toxic and unstable compound, so we choose the hot injection method to synthesize CZTS nanoparticles. We have successfully synthesized high quality CZTS nanoparticles by the hot injection method, and we discussed the CZTS growth mechanism via tuning reaction conditions. We used TEM to observe the size of different nanoparticles, and explained its nucleation and growth mechanism by LaMer model. We also measured CZTS by using XRD and Raman spectrum to identify its structures and phases, and we found that different crystallinity in different reaction condition. Different from other hot injection methods, we used slow injection synthesis to get the high quality CZTS, and we proposed a possible reason to explain why the CZTS nanoparticles possessed different cystallinity. Ostwald ripening and oriented attachment are two mechanisms which may result in different crystallinity during the growth. Moreover, we also observed wurtzite and kesterite CZTS would coexist in the hot injection synthesis.
Hsu, Shun-Ting y 許舜婷. "Effect of Injecting Minor Liquid Carbon Sources on Graphite Encapsulated Nickel Nanoparticles Synthesis and Arc-shape Conversion". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/25537008826060792842.
Texto completo國立臺灣大學
地質科學研究所
104
Graphite Encapsulated Metal (GEM) nanoparticles are spherical core-shell structured composite material with a diameter ranging from 5–100 nm. The core of GEM is metal, and its outer shell is composed of several layers of graphite/graphene which can preserve the inner core in a severe environment, such as from acid erosion and oxidation. It is well known that many different functional groups, including carboxyl and hydroxyl, can be easily attached to the surface of carbon materials. Recently, several studies have revealed that GEM has a great potential to become a novel material including, for example, in hydrogen storage and biomedical materials due to its unique properties. For instance, Wu et al.(2007) used polyethylene glycol and folic acid grafted on Fe-GEM for the heat treatment of cancer, and Chung et al. (2009) used Co-GEM as an electrochemical hydrogenation material. The modified tungsten arc-discharge method was developed by Teng et al. and Dravid et al. in 1995. This is the most practical method for producing a large quantity of GEM because it reduces the amount of carbon debris origin compared to the Krätschmer–Huffman method. However, the encapsulation efficiency of GEM remains low. Until 2012, with the help of the two-step mechanism model, we used n-propanol as the liquid carbon source to synthesize GEM, significantly increasing its encapsulation efficiency from 20–30 wt% to around 80 wt%, and presenting a preliminary method for controlling the particle size of GEM through different liquid carbon sources. However, we faced two difficult issues after switching the carbon source from solid to liquid. First, this method could disturb the arc discharge which causes the discontinuity of the experiment, leading to the lockout unsustainable injection. Second, the consumption rate of the tungsten rod rose from 1 mm/h to 420 mm/h, making it difficult to synthesize large quantities of well-encapsulated GEM. In addition, the detailed mechanism, after entering the liquid carbon source, still remains unclear. The purposes of this study are to realize the changes of arc in the cabin and to resolve problems after using the liquid carbon source. In order to solve the problems, this research has installed a liquid metering pump to regulate the amount and direction of each injection, so that the carbon source can be directed to mainly spray the synthetic region of GEM, which is called the coalescence region. This method avoids the resistance caused by dripping liquid along the tungsten rod, and successfully sustained the experiment. The TEM images show that the synthesized GEMs, using a liquid metering pump, retain a complete core-shell structure, and the utilization of carbon source calculated by TGA data shows significant improvement, from 20% to 64%. Furthermore, we listed the possible reasons causing the high consumption rate of tungsten rod, and verified them by theoretical calculation and manner of experiments, one by one. It can be speculated by OES data that the dominant gas in the center of the arc changed from helium to hydrogen. In the meantime, the arc temperature rose show by the color changing into blue and white, representing the higher arc temperature is the main reason causing the tungsten melting rate to increase 420-fold. After calculating the heat conduction, we confirmed that increasing the diameter of the tungsten rod can immediately solve this problem. Since it is feasible to control the injection rate through the use of a liquid metering pump, we tried to figure out the encapsulation efficiency of GEM over time when synthesizing GEM. Under the same experimental parameters and total liquid injection volume, we compared the results of two different injection rates, 10μL/min and 100μL/min, and found that using the former injection rate can result in 5-fold higher encapsulation efficiency. According to the two-step mechanism of GEM, we speculated that adding liquid carbon source during arc discharge would rapidly increase the carbon proportionate of the coalescence region; however, the carbon vapor will quickly leave the coalescence region via convection. Thus, for the same total liquid injection volume, taking a small amount and injecting it a few times is the best way to inject the liquid carbon source; it can significantly improve the encapsulation efficiency and the utilization rate of the carbon source. Lastly, based on the experiment results, we proposed a model that can explain the transformation of the arc body from bell-shaped to columnar, after injecting the liquid carbon sources. Furthermore, our model raises the potential of employing GEM to fundamental science and applied material fields.
Huang, Yen-Hsiang y 黃彥翔. "Preparation of Amperometric Phenol Sensors by Integrating Multi-Walled Carbon Nanotubes with Silver Nanoparticles (Ag@MWCNTs) and Potential to Apply in the Flow Injection Analysis (FIA) System". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/44898325366478909414.
Texto completo國立臺灣科技大學
化學工程系
103
This study is comprised of two parts: the first part focused on the synthesis of the complexes of Ag@carbon nanotubes (Ag@CNTs) and preparation of horseradish peroxidase (HRP) biosensor. Carbon nanotubes (CNTs) have drawn considerable attention in recent years because of their superior properties that include the larger specific surface area and more electrocatalytic activity, which can significantly enhance the amperometric anodic signal. In this study, the incorporation of Ag nanoparticles on CNTs aimed to enhance the electrical conductivity and reduce the contact resistance. Moreover, various analytical tools were employed to verify the physical-chemical and morphology characteristics of the prepared Ag@CNTs. An amperometric biosensor base on HRP and chitosan- Ag@carbon nanotubes (Ch-Ag@CNTs) on screen printed carbon electrode (SPE). The current responses were detected by phenolic compound at applied voltage -50 mV. The results showed that two sensitivity of phenol detection were 2.37 μA/μM cm2 (0.75 - 100 μM, R2:0.976) and 0.749 μA/μM cm2 (100 - 400 μM, R2:0.979) and limitation of detection was 0.375 μM. It retained 80% of its initial current response after 30 days. For the second part, a custom-made flow channel was applied which mainly plays the role of minimize the required components for reactions and further facilitated the integration, automation, and parallelization for the designated biochemical processes. In addition, the prepared Ch-Ag@CNTs in the first part and HRP were incorporated on SPE for the detection of phenol, which was further combined with a custom-made flow channel, to form “Flow Injection Analysis” (FIA). The FIA designed in this study allows the manipulation of small fluid volume, from micro- down to pico- liter, with exceptional accuracy. In summary, the proposed FIA would have the advantages including low price, rapid response time, high accuracy, and smaller reaction volume that can reduce the thickness of the diffusion layer and effectively convey electronic signals between solid-liquid phases when compared with the conventional system, and could be utilized for a wider range of applications. The results showed that the sensitivity of phenol detection were 2.77 μA/μM cm2 (0.5 - 20 μM, R2:0.974).
Rode, García Teresita. "Étude de l’influence de différentes méthodes de fabrication sur l’architecture et les propriétés physico-chimiques des nanoparticules à base de PEG-b-PLA". Thèse, 2017. http://hdl.handle.net/1866/20551.
Texto completoLe, Renard Pol-Edern. "Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors". Phd thesis, 2011. http://tel.archives-ouvertes.fr/tel-00709676.
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