Bibliografías temáticas / Nanomagnetism - Small Molecular Organic Ligands

Literatura académica sobre el tema "Nanomagnetism - Small Molecular Organic Ligands"

Autor: Grafiati
Publicado: 7 de septiembre de 2023

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Artículos de revistas sobre el tema "Nanomagnetism - Small Molecular Organic Ligands"

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Milanesi, Eva, Paola Costantini, Alberto Gambalunga, Raffaele Colonna, Valeria Petronilli, Anna Cabrelle, Gianpietro Semenzato, Andrea M. Cesura, Emmanuel Pinard y Paolo Bernardi. "The Mitochondrial Effects of Small Organic Ligands of BCL-2". Journal of Biological Chemistry 281, n.º 15 (14 de febrero de 2006): 10066–72. http://dx.doi.org/10.1074/jbc.m513708200.

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2

Nilsson, K. Peter R. "Small organic probes as amyloid specific ligands - Past and recent molecular scaffolds". FEBS Letters 583, n.º 16 (17 de abril de 2009): 2593–99. http://dx.doi.org/10.1016/j.febslet.2009.04.016.

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3

Reiner, Thomas, Sarah Earley, Anna Turetsky y Ralph Weissleder. "Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells". ChemBioChem 11, n.º 17 (21 de octubre de 2010): 2374–77. http://dx.doi.org/10.1002/cbic.201000477.

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4

Wijtmans, Maikel, Dennis Verzijl, Rob Leurs, Iwan J. P. de Esch y Martine J Smit. "Towards Small-Molecule CXCR3 Ligands with Clinical Potential". ChemMedChem 3, n.º 6 (16 de junio de 2008): 861–72. http://dx.doi.org/10.1002/cmdc.200700365.

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5

Blalock, J. E. "On the evolution of ligands: did peptides functionally precede metals and small organic molecules?" Cellular and Molecular Life Sciences (CMLS) 55, n.º 4 (1 de abril de 1999): 513–18. http://dx.doi.org/10.1007/s000180050309.

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6

Scodeller, Pablo y Eliana K. Asciutto. "Targeting Tumors Using Peptides". Molecules 25, n.º 4 (13 de febrero de 2020): 808. http://dx.doi.org/10.3390/molecules25040808.

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To penetrate solid tumors, low molecular weight (Mw < 10 KDa) compounds have an edge over antibodies: their higher penetration because of their small size. Because of the dense stroma and high interstitial fluid pressure of solid tumors, the penetration of higher Mw compounds is unfavored and being small thus becomes an advantage. This review covers a wide range of peptidic ligands—linear, cyclic, macrocyclic and cyclotidic peptides—to target tumors: We describe the main tools to identify peptides experimentally, such as phage display, and the possible chemical modifications to enhance the properties of the identified peptides. We also review in silico identification of peptides and the most salient non-peptidic ligands in clinical stages. We later focus the attention on the current validated ligands available to target different tumor compartments: blood vessels, extracelullar matrix, and tumor associated macrophages. The clinical advances and failures of these ligands and their therapeutic conjugates will be discussed. We aim to present the reader with the state-of-the-art in targeting tumors, by using low Mw molecules, and the tools to identify new ligands.
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7

Kim, Hyeon Jin, Mi Suk Jeong y Se Bok Jang. "Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors". International Journal of Molecular Sciences 22, n.º 13 (27 de junio de 2021): 6904. http://dx.doi.org/10.3390/ijms22136904.

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Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage-associated molecular pattern molecules), such as AGEs, HMGB1, and S100/calgranulins, and as an innate immune sensor, can recognize microbial PAMPs (pathogen-associated molecular pattern molecules), including bacterial LPS, bacterial DNA, and viral and parasitic proteins. RAGE and its ligands stimulate the activations of diverse pathways, such as p38MAPK, ERK1/2, Cdc42/Rac, and JNK, and trigger cascades of diverse signaling events that are involved in a wide spectrum of diseases, including diabetes mellitus, inflammatory, vascular and neurodegenerative diseases, atherothrombosis, and cancer. Thus, the targeted inhibition of RAGE or its ligands is considered an important strategy for the treatment of cancer and chronic inflammatory diseases.
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8

Tassinari, Martina, Alberto Lena, Elena Butovskaya, Valentina Pirota, Matteo Nadai, Mauro Freccero, Filippo Doria y Sara Richter. "A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety". Molecules 23, n.º 8 (27 de julio de 2018): 1874. http://dx.doi.org/10.3390/molecules23081874.

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G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and infectious diseases; however, G4 targeting compounds still need implementation in terms of drug-like properties and selectivity in order to reach the clinical use. So far, G4 ligands have been mainly identified through high-throughput screening methods or design of molecules with pre-set features. Here, we describe the development of new heterocyclic ligands through a fragment-based drug discovery (FBDD) approach. The ligands were designed against the major G4 present in the long terminal repeat (LTR) promoter region of the human immunodeficiency virus-1 (HIV-1), the stabilization of which has been shown to suppress viral gene expression and replication. Our method is based on the generation of molecular fragment small libraries, screened against the target to further elaborate them into lead compounds. We screened 150 small molecules, composed by structurally and chemically different fragments, selected from commercially available and in-house compounds; synthetic elaboration yielded several G4 ligands and two final G4 binders, both embedding an amidoxime moiety; one of these two compounds showed preferential binding for the HIV-1 LTR G4. This work presents the discovery of a novel potential pharmacophore and highlights the possibility to apply a fragment-based approach to develop G4 ligands with unexpected chemical features.
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9

Gómez-Santacana, Xavier, Sabrina M. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans y Rob Leurs. "A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light". Beilstein Journal of Organic Chemistry 15 (23 de octubre de 2019): 2509–23. http://dx.doi.org/10.3762/bjoc.15.244.

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We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3. A series of photoswitchable azobenzene ligands was prepared through various synthetic strategies and multistep syntheses. Photochemical and pharmacological properties were used to guide the design iterations. Investigations of positional and substituent effects reveal that halogen substituents on the ortho-position of the outer ring are preferred for conferring partial agonism on the cis form of the ligands. This effect could be expanded by an electron-donating group on the para-position of the central ring. A variety of efficacy differences between the trans and cis forms emerges from these compounds. Tool compounds VUF15888 (4d) and VUF16620 (6e) represent more subtle efficacy switches, while VUF16216 (6f) displays the largest efficacy switch, from antagonism to full agonism. The compound class disclosed here can aid in new photopharmacology studies of CXCR3 signaling.
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10

Porter, John, Andrew Payne, Ian Whitcombe, Ben de Candole, Daniel Ford, Rachel Garlish, Adam Hold et al. "Atropisomeric small molecule Bcl-2 ligands: Determination of bioactive conformation". Bioorganic & Medicinal Chemistry Letters 19, n.º 6 (marzo de 2009): 1767–72. http://dx.doi.org/10.1016/j.bmcl.2009.01.071.

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Tesis sobre el tema "Nanomagnetism - Small Molecular Organic Ligands"

1

Soules, Régis. "Proprietes cooperatives de complexes polymetalliques des ligands squarate et thiosquarate". Toulouse 3, 1987. http://www.theses.fr/1987TOU30178.

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Etude de l'emploi d'un coordinat assembleur qui puisse par coordination avec le centre metallique utilise (metaux de transition du groupe viii) aboutir a un agencement a une dimension des motifs moleculaires par empilement d'entites monomeres ou par formation de chaines. Par utilisation du coordinat squarate sous ses formes oxygenees et soufrees, obtention d'un certain nombre de complexes de pt, pd, ni et cu repondant aux criteres fixes. Etude des structures de ces composes, de leurs proprietes physiques et de la relation structure-propriete. La nature du coordinat comme le caractere specifique de l'arrangement structural ont ete discutes pour une approche de la comprehension de la nature de ces proprietes physiques
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