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Tesis sobre el tema "Mycobacterium tuberculosis σ Factors"

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Publicado: 6 de septiembre de 2023

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1

Moses, Lorraine. "Phenotypic factors influencing Mycobacterium tuberculosis phenotype." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52997.

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2

Davies, Angharad Puw. "A study of resuscitation-promoting factors in Mycobacterium tuberculosis." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445460/.

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Tuberculosis is a major threat to human health. About one third of the world's population is latently infected with Mycobacterium tuberculosis . In these cases the bacillus is in a state of low metabolic activity, making eradication difficult with conventional chemotherapy, which targets actively metabolizing organisms. The mechanisms by which M. tuberculosis reactivates to cause disease are currently unknown but a better understanding could greatly improve the treatment of tuberculosis. Resuscitation-promoting factor is a protein first identified in the supernatant of stationary phase culture
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3

Hanekom, Madeleine. "The molecular epidemiology of Mycobacterium tuberculosis : host and bacterial factors perpetuating the epidemic." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4821.

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Thesis (PhD (Biomedical Sciences. Molecular Biology and Human Genetics))--University of Stellenbosch, 2009.<br>Dissertation presented for the degree of Doctor of Philosophy at Stellenbosch University.<br>ENGLISH ABSTRACT: This study describes the molecular epidemiology of Mycobacterium tuberculosis strains with the Beijing genotype. This genotype has received clinical prominence due to its global distribution and the hypothesis that these strains have acquired the ability to evade the protective effect of BCG vaccination, spread more readily, acquire drug resistance and cause severe forms o
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4

Tanina, ABDALKARIM. "Structural analysis of transcription factors involved in Mycobacterium tuberculosis mycolic acid biosynthesis." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/309485.

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Tuberculosis (TB) remains the leading cause of death due to a single infectious agent with more than 1.5 million people killed each year. In 2018, the World Health Organization (WHO) estimated that one third of the world’s population was infected with Mycobacterium tuberculosis (Mtb), the pathogen responsible for the disease.In 2000, EthR, a mycobacterial transcriptional repressor, was identified as a key modulator of ethionamide (ETH) bioactivation. ETH is one of the main second-line drugs used to treat drug-resistant strains and it is a prodrug that is activated in Mtb by the mono-oxygenase
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5

AlcÃntara, Cid Carlos Soares de. "Fatores associados ao diagnÃstico de tuberculose pulmonar entre suspeitos da doenÃa na rotina de unidades de saÃde de Fortaleza, CE." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5815.

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A Tuberculose (Tb) à uma doenÃa que tem desafiado a humanidade desde a antiguidade. Acreditava-se que com as novas tecnologias, as doenÃas infecto-contagiosas seriam facilmente controladas e banidas. A realidade, porÃm tem-se apresentado de modo diferente; apesar dos avanÃos no conhecimento da tuberculose e tecnologia disponÃvel para seu controle, o quadro atual encontra-se muito distante das metas estabelecidas pelos governos. à essencial o estudo dos fatores associados à tuberculose pulmonar, uma vez que eles estÃo presentes na primo-infeccÃÃo, na recidiva e na Tb pulmonar multi-resistente.
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6

Crossman, David K. "Characterization of a novel acetyltransferase found only in pathogenic strains of Mycobacterium tuberculosis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007r/crossman.pdf.

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7

Kocabas, Evren. "Identification of native co-factors of MshB and MCA from Mycobacterium species." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/44457.

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Mycothiol (MSH), a low-molecular- weight thiol, is a primary reducing agent and essential for the survival of mycobacteria. The full pathway of MSH biosynthesis and detoxification includes various promising drug targets. Several metalloenzymes are involved in this pathway, such as a deacetylase (MshB) and mycothiol S-conjugate amidase (MCA). MshB catalyzes the deacetylation of GlcNAc-Ins to form GlcN-Ins and acetate. Mycothiol S-conjugate amidase (MCA) cleaves the amide bond of mycothiol S-conjugates of various drugs and toxins. The identification of the native co-factor is critical for the de
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8

Dupont, Maeva. "Identification of novel factors involved in the exacerbation of HIV-1 infection and spread among macrophages in the tuberculosis context." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30211.

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Mycobacterium tuberculosis (Mtb), la bactérie responsable de la tuberculose (TB), et le virus de l'immunodéficience humaine (VIH-1), l'agent du syndrome de l'immunodéficience acquise (SIDA), accélèrent leurs progressions mutuelles chez les patients co-infectés. Alors que de nombreuses données cliniques rapportent une augmentation de la charge virale dans les sites anatomiques co-infectés, les mécanismes qui en sont responsables restent insuffisamment décrits. Mtb cible principalement les macrophages. Nous émettons l'hypothèse que l'infection des macrophages par Mtb créé un microenvironnement p
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9

Bortoluzzi, Alessio. "Structural characterization of Mycobacterium tuberculosis RNA polymerase binding protein A (RbpA) and its interactions with sigma factors." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28401.

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The RNA polymerase binding protein A (RbpA) is a 13 kDa protein, encoded by the gene Rv2050, that was shown to be essential for the growth and survival of the important human pathogen Mycobacterium tuberculosis. Although is not clear yet why RbpA is essential in M. tuberculosis, significant progress has been made in the characterization of the protein. For instance, it was shown that RbpA binds to the β-subunit of the RNA polymerase (RNAP) and activates transcription. Interestingly, it was reported that RbpA can enhance the transcription activity of the RNAP containing the primary σ-subunit σ[
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10

Molino, Lucilia Pereira Dutra. "Infecção latente por Mycobacterium tuberculosis entre contatos de pacientes com tuberculose pulmonar cavitária e não cavitária." Universidade Federal do Espírito Santo, 2009. http://repositorio.ufes.br/handle/10/5917.

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Made available in DSpace on 2016-12-23T13:56:04Z (GMT). No. of bitstreams: 1 DISSERTACAO FINAL.pdf: 1304058 bytes, checksum: 22df93a24605e7e83e388686a27fb38f (MD5) Previous issue date: 2009-05-29<br>The tuberculosis continues to represent a severe worldwide public health issue, particularly in developing countries. Besides early diagnosis and therapy, one of the great challenges for its control is the scarce knowledge available about the transmission mechanisms and the related risks. The retrospective cohort described in this study aims to evaluate the risk of Mycobacterium tuberculosis infe
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11

Liu, Dien. "Effects of R294C mutation on expression and stability of interferon regulatory factor-8 in BXH-2 mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116090.

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Interferon regulatory factor-8 (Irf-8), a hematopoietic transcriptional regulator, controls myeloid-cell proliferation and coordinates innate and adaptive host immune responses. Mice from the BXH-2 recombinant inbred strain carry an endogenous R294C mutation in Irf-8. This loss-of-function mutation induces clonal infiltration of undifferentiated Mac-1+/Gr-1 + granulocytic precursors in BXH-2 mice, extramedullary hematopoiesis, and splenomegaly similar to those seen in human chronic myeloid leukemia. It also renders the host permissible to the otherwise avirulent Mycobacterium bovis (BCG), and
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12

Kelly, Robert Francis. "Epidemiology of bovine tuberculosis and influence of liver fluke co-infection in Cameroon, Central Africa." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29560.

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Despite Africa accounting for ~20% of the global cattle population, prevalence estimates and related risk factors of bovine tuberculosis (bTB), caused by Mycobacterium bovis, are still poorly quantified in many countries across the continent. Control of bTB in Africa is difficult due to poor monitoring of cattle movements and limited abattoir surveillance. Also M. bovis is zoonotic and risk factors for transmission include living in close contact with cattle and consumption of unpasteurised milk. Cattle keeping is integral to some rural populations in Cameroon and understanding the epidemiolog
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13

Carvalho, BrÃulio Matias de. "Epidemiological study and resistance patterns to the anti-tuberculosis drugs in mycobacteria and hiv co-infected patients in a reference hospital in Fortaleza, CearÃ." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2504.

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nÃo hÃ<br>The HIV infection and the tuberculosis (TB) are together the main causes of death for infectious agents in the world, being approximately 13 million people infected with both causative agents. The HIV-infected individuals show increased susceptibility for active tuberculosis, being the imunosupression caused by the virus the main risk factor for the development for active TB. This study investigated the profile of Mycobacterium tuberculosis drug resistance and evaluated the factors related to the development of TB in HIV infected patients who were treated at HSJ, which is a reference
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14

Alvarez, Martinez Jesus Antonio. "Role of [gamma][delta]-T cells in mycobacterial infection and inflammation /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcitt?p9999268.

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15

Andriuška, Algirdas. "Vaikų tuberkuliozės kontrolės galimybės vykdant valstybinę tuberkuliozės profilaktikos ir kontrolės 2003–2006 m. programą." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050610_093210-17713.

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SUMMARY Aim of the study. To evaluate the possibilities of control of the children tuberculosis in Kaunas County. Objectives. 1. To evaluate the epidemiological situation of the children tuberculosis in Kaunas County in 1996 – 2003. 2. To evaluate the problems of early diagnostics and treatment of the children tuberculosis. 3. To propose the possible means of control of the children tuberculosis. Methods. Study objects were the patients with active tuberculosis treated in the Department of Children Pulmonology of Kaunas II hospital during 1996–2003 and general practitioners (GP) working in Pri
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16

Awah, Ndukum Julius. "Epidemiology and public health significance of bovine tuberculosis in cattle in the highlands of Cameroon." Thesis, University of Plymouth, 2012. http://hdl.handle.net/10026.1/913.

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Bovine tuberculosis (TB) is a contagious neglected zoonosis of cattle that is prevalent but under-investigated in Cameroon, hence this study was designed to assess the epidemiology of bovine TB in cattle, risks for M. bovis infection in cattle and humans; and public health implications of zoonotic bovine TB in the highlands of Cameroon. A retrospective study of meat inspection records (1994 – 2010) was done to estimate the prevalence of TB lesions in slaughtered cattle in the North West region. The prevalence of bovine TB and anti-bovine TB antibodies in live cattle based on tuberculin skin te
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17

Hartman, Michelle L. "M.tb Killing by Macrophage Innate Immune Mechanisms: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/606.

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Macrophages infected with a heavy burden of M.tb Erdman undergo a cell death that initially resembles apoptosis but quickly transitions to necrosis. Unlike the previously reported TNF dependent apoptosis induced by avirulent Mycobacterium [1], this form of macrophage cell death is not microbicidal [2]. Microbicidal effects are observed however, when the heavily infected macrophage encounters an uninfected naïve macrophage. My studies describe in part, the crosstalk between the uninfected and infected macrophage that results in the killing of the intracellular M.tb Cell contact between the two
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18

Jamithireddy, Anil Kumar. "Biophysical Studies on Mycobacterium Tuberculosis σ Factor – Regulatory Protein Complexes". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4170.

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Adaptation to external environmental conditions is essential for the survival of a bacterial cell. Bacteria have thus evolved multiple mechanisms to sense environmental stimuli and to couple this information into an appropriate cellular response. The cellular response, in its simplest sense involves a change in the cellular content which is achieved by regulating gene expression. Gene expression in bacteria is primarily regulated at the first step, also referred to as transcription initiation. Extensive studies on this mechanism over the past two decades provide a molecular picture of this p
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19

Goutam, Kapil. "Structural and Functional Studies on the Mycobacterium tuberculosis σ factor σJ". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/3566.

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Regulation of transcription in prokaryotes is primarily governed at the transcription initiation step. This feature has been extensively characterized in model prokaryotes notably Escherichia coli and Bacillus subtilis. Transcription initiation was initially thought to be governed primarily by initiation factors that recruit the RNA polymerase (RNAP) enzyme to initiate expression of given gene. Recent studies reveal multiple mechanisms at play including additional protein factors that can modulate gene expression. Nonetheless, understanding transcription factors is key to rationalize the nuanc
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20

Goutam, Kapil. "Structural and Functional Studies on the Mycobacterium tuberculosis σ factor σJ". Thesis, 2017. http://etd.iisc.ernet.in/2005/3566.

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Regulation of transcription in prokaryotes is primarily governed at the transcription initiation step. This feature has been extensively characterized in model prokaryotes notably Escherichia coli and Bacillus subtilis. Transcription initiation was initially thought to be governed primarily by initiation factors that recruit the RNA polymerase (RNAP) enzyme to initiate expression of given gene. Recent studies reveal multiple mechanisms at play including additional protein factors that can modulate gene expression. Nonetheless, understanding transcription factors is key to rationalize the nuanc
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21

Shukla, Jinal K. "Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK". Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3904.

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A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host suggests an adaptive mechanism in M. tuberculosis that can cope with a variety of environmental stresses and other host stimuli. Extensive genomic studies and analysis of knock-out phenotypes revealed elaborate cellular machinery in M. tuberculosis that ensures a rapid cellular response to host stimuli. Prominent amongst these are two-component systems and σ factors that ex
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22

Shukla, Jinal K. "Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK". Thesis, 2013. http://etd.iisc.ernet.in/2005/3904.

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A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host suggests an adaptive mechanism in M. tuberculosis that can cope with a variety of environmental stresses and other host stimuli. Extensive genomic studies and analysis of knock-out phenotypes revealed elaborate cellular machinery in M. tuberculosis that ensures a rapid cellular response to host stimuli. Prominent amongst these are two-component systems and σ factors that ex
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23

Gopal, Krishan. "Structural And Biophysical Analysis Of The Regulatory Mechanism Of Mycobacterium Tuberculosis Sigma Factors." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/958.

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Mycobacterium tuberculosis has one ribosomal RNA operon. The survival of this bacillus thus depends on a transcription mechanism that can effectively couple gene expression to changes in the environment. σ factors are transcription proteins that bind to the RNA polymerase (RNAP) and dictate gene expression. Extra Cytoplasmic Function σ factors (ECF) are a subset of σ factors that coordinate environment-induced changes in transcription. The environment specific binding of ECF σ factors to the RNAP presents an effective mechanism for the bacillus to modulate gene expression. ECF σ factors, i
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24

Gopal, Krishan. "Structural And Biophysical Analysis Of The Regulatory Mechanism Of Mycobacterium Tuberculosis Sigma Factors." Thesis, 2009. http://hdl.handle.net/2005/958.

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Mycobacterium tuberculosis has one ribosomal RNA operon. The survival of this bacillus thus depends on a transcription mechanism that can effectively couple gene expression to changes in the environment. σ factors are transcription proteins that bind to the RNA polymerase (RNAP) and dictate gene expression. Extra Cytoplasmic Function σ factors (ECF) are a subset of σ factors that coordinate environment-induced changes in transcription. The environment specific binding of ECF σ factors to the RNAP presents an effective mechanism for the bacillus to modulate gene expression. ECF σ factors, i
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25

Carmo, Nuno Baltazar do 1976. "Human factors required for mycobacterium tuberculosis macrophage infection." Doctoral thesis, 2013. http://hdl.handle.net/10451/15626.

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Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Tuberculosis is a pathological manifestation of the infection by Mycobacterium tuberculosis in humans. Facultative intracellular parasites, like M. tuberculosis, evolved mechanisms to subvert the proper functioning of their host cells to their benefit. In this thesis we token advantage of the characteristics of the fluorescent proteins to develop methodologies based on fluorimetry to quantify the macrophage internalization and the number of intracellular mycobacteria. The appli
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26

Mapela, Lusanda Thato. "Characterization of resuscitation promoting factors in Mycobacterium smegmatis." Thesis, 2012. http://hdl.handle.net/10539/11937.

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Mycobacterium tuberculosis, the causative agent of tuberculosis (TB) has infected one third of the world’s population and continues to claim more lives annually than any other infectious disease agent. A significant proportion of individuals carry latent TB infection (LBTI) which is characterized by the absence of clinical symptoms and it has been postulated that the tubercle bacilli are in a dormant-like state during this type of infection. Resuscitation promoting factors (Rpfs) are cell wall hydrolases which cleave glycosidic bonds within the peptidoglycan (PG), a mechanism thought to
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27

Hsu, Ai-Hsi, and 胥愛璽. "The Study of Host-Related Factors in Infection of Mycobacterium tuberculosis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/76522430679624501243.

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博士<br>慈濟大學<br>醫學科學研究所<br>101<br>The annual incidence of new pulmonary tuberculosis cases in Eastern Taiwan was significantly higher than average incidence across Taiwan. In the first chapter, the theme of the research is to explore Mycobacterium tuberculosis (Mtb) outbreaks amongst hosts. Take advantage of the molecular tools combined spoligotying and mycobacterial interspersed repetitive unit-variable tandem-repeat (MIRU-VNTR), two PCR-based techniques, we may identify Mtb genotype and explore the multi drug-resistant tuberculosis (MDRTB) transmission in Eastern Taiwan. The results showed a 6
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28

Pope, Steven Scott. "Roles of transcription factors, RBPA and SIGF, in the mycobacterium tuberculosis." Thesis, 2015. https://hdl.handle.net/2144/16201.

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The mechanism of prokaryotic transcription has been characterized primarily in the classic system, Escherichia coli, and cannot be confidently extended to include other prokaryotic species, such as those of the Actinobacteria phylum. Actinobacteria represents a diverse group of Gram-positive species that range from soil dwellers to obligate pathogens, such as Mycobacterium tuberculosis (Tb). These species encode RNA polymerase (RNAP) binding proteins that are not present in model organisms, and therefore present a unique lens through which the basic mechanism of transcription can be further ex
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Shahbaaz, Mohd. "Computational and experimental studies of putative virulence factors of Mycobacterium tuberculosis H37Rv." Thesis, 2017. http://hdl.handle.net/10321/2661.

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Submitted in fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry, Durban University of Technology, Durban, South Africa, 2017.<br>In drug discovery and development of anti-tubercular therapeutics, it is necessary to study the physiology and genetics of the molecular mechanisms present in the Mycobacterium tuberculosis. The virulence of M. tuberculosis is attributed to its unique genome, which contains a high frequency of glycine-rich proteins and genes involved in the metabolism of the fatty acids. Consequently, the presence of a diversity of the pathogenic path
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30

Weng, Shang-Hui, and 翁上惠. "Bacterial Factors Involved in Mycobacterium marinum and Mycobacterium tuberculosis Type VII Secretion System Induced NLRP3 Inflammasome Activation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/598j62.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>107<br>Human tuberculosis, also known as "the white plague", mainly results from Mycobacterium tuberculosis infection which was found in early human history. Due to the long incubation period and drug resistance of M. tuberculosis, the researches of diagnosis and treatment in tuberculosis still remain a considerable development space. Generally, many studies on M. tuberculosis and tuberculosis use Mycobacterium marinum with higher safety and faster growth rate as a model in laboratory works. M. marinum shows high conservation with M. tuberculosis in genetic relations
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31

Leung, Andrea. "Genetic Factors Influencing BCG Vaccine Properties." Thesis, 2010. http://hdl.handle.net/1807/25756.

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Tuberculosis is a re-emerging global health problem. Bacille Calmette-Guerin (BCG), the available vaccine against the disease, is only effective short term and is associated with adverse reactions clinically. The development of new effective vaccines will require an understanding of virulence, immunogenic factors and the beneficial immune responses induced in the human host. My thesis investigates phoP and whiB3, two genes associated with virulence and immunogenicity in Mycobacterium tuberculosis. Study of PhoP in a natural phoP mutant, BCG-Prague, and in the clinically safe BCG-Japan, sho
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Timóteo, Pedro Manuel Dias 1990. "Deciphering host factors for mycobacteria internalization during phagocytosis." Master's thesis, 2013. http://hdl.handle.net/10451/9472.

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Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2013<br>A tuberculose é uma doença infecciosa que tem acompanhado historicamente a Humanidade. Caracteriza-se tipicamente por uma infecção pulmonar, manifestando-se através de tosse persistente, febre e especialmente por uma fraqueza generalizada. Apesar da sua ancestralidade, é ainda hoje a doença infecciosa responsável pelo maior número de mortes a nível mundial. O agente etiológico da tuberculose é uma bactéria, Mycobacterium tuberculosis, descrita pela primeira vez por Robert Koch no século
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"A multilevel analysis of factors associated with clustered strains of Mycobacterium tuberculosis in Louisiana." Tulane University, 2007.

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Ndwandwe, Duduzile Edith. "Mechanisms of mutagenesis in Mycobacterium tuberculosis: structural and functional characterisation of the DNA polymerase accessory factors encoded by Rv3394c and Rv3395c." Thesis, 2013. http://hdl.handle.net/10539/12918.

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A thesis submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Doctor of Philosophy February 2013<br>Mycobacterium tuberculosis is presented with environmental host assaults that damage its DNA during infection. Tubercle bacilli possess mechanisms to protect against moststresses imposed by the host, including genotoxic stress. However, tolerance of DNA lesions that have escaped the normal repair processes requires the function of specialist DNA polymerases that can introduce mutations during translesion s
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Wolf, Andrea J. "In vivo analysis of factors affecting the dynamics of the adaptive immune response to Mycobacterium tuberculosis and contributing to bacterial persistence." Diss., 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3289328.

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Mitra, Anirban. "Insights into Occurrence and Divergence of Intrinsic Terminators and Studies on Rho-Dependent Termination in Mycobacterium Tuberculosis." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3382.

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Two mechanisms, intrinsic and factor-dependent, have evolved for accomplishing the termination of transcription in eubacteria. In this thesis, the first chapter is an introduction to the topic that presents what is known about the mechanisms of termination. The properties of the primary and secondary ‘players’- intrinsic terminators, Rho protein, rho-dependent terminators, RNA polymerse and Nus factors - are presented and the known mechanisms by which termination functions are discussed. In Chapter 2, a detailed analysis of intrinsic terminators – their differential distribution, similarity an
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37

Mitra, Anirban. "Insights into Occurrence and Divergence of Intrinsic Terminators and Studies on Rho-Dependent Termination in Mycobacterium Tuberculosis." Thesis, 2013. http://etd.iisc.ernet.in/2005/3382.

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Two mechanisms, intrinsic and factor-dependent, have evolved for accomplishing the termination of transcription in eubacteria. In this thesis, the first chapter is an introduction to the topic that presents what is known about the mechanisms of termination. The properties of the primary and secondary ‘players’- intrinsic terminators, Rho protein, rho-dependent terminators, RNA polymerse and Nus factors - are presented and the known mechanisms by which termination functions are discussed. In Chapter 2, a detailed analysis of intrinsic terminators – their differential distribution, similarity an
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38

Jha, Rajiv Kumar. "Insights into the Regulation of Transcription Initiation of DNA Gyrase and Role of Transcription Factor Gre from Mycobacterium tuberculosis." Thesis, 2017. https://etd.iisc.ac.in/handle/2005/4681.

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Genus Mycobacterium comprises a large number of species including many pathogens such as Mycobacterium leprae, Mycobacterium abscessus and Mycobacterium tuberculosis (Mtb), the last one is the causative agent of the fatal disease tuberculosis. The unique features of the deadly organism viz, slow growing, tough cell wall, latency and resistance to various drugs demand a systematic understanding of many essential molecular processes including transcription. Studies have been undertaken to understand several aspects of transcription in mycobacteria which revealed its machinery to be conserved wit
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39

Moiane, Ivânia Cláudia. "Prevalence and risk factors of bovine tuberculosis in cattle in rural areas of Govuro district in the southeast of Mozambique." Master's thesis, 2013. http://hdl.handle.net/1822/45376.

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Dissertação de Mestrado em Ciências da Saúde<br>In Mozambique, bovine tuberculosis (BTB) is a serious problem for livestock development; however, surveillance and control programs are not applied consistently and systematically. This disease has direct economic repercussions on livestock due to lower productivity of infected animals, as well as the increased rejection of carcasses at the slaughterhouses. Due to the direct economic repercussions and indirect consequences for human health, knowing the precise distribution of the disease throughout the country is essential to define an effec
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40

Prakhar, Praveen. "Wnt/β-Catenin-dependent Epigenetic Factors Shape Host Immune Responses During Mycobacterial Infection". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4226.

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The genus mycobacterium has more than 120 species of bacteria; one being M. tuberculosis (Mtb), the etiological agent of tuberculosis (TB). During infection, the host mounts a heightened immune response to contain the spread of the pathogen. Facilitating the response mediated by the host, PRRs (Pattern Recognition Receptors), upon their interaction with cognate ligands set forth a plethora of signaling cascades that effectuate responses like inflammation, apoptosis or autophagy to eradicate mycobacteria from the system. The early responses against Mtb are brought about by macrophages, dendriti
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Ackah, Shiroma. "The association of demographics and occupational factors with latent tuberculosis infection in radiology staff at public sector hospitals in the eThekwini health district." Thesis, 2015. http://hdl.handle.net/10321/1422.

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Submitted in fulfillment of the requirements for the degree of Master’s of Technology: Radiography, Durban University of Technology, Durban, South Africa, 2015.<br>Introduction Tuberculosis remains a leading cause of death, second to the Human Immunodeficiency Virus. The risk of latent tuberculosis infection and active tuberculosis disease is a known occupational hazard. In South Africa, a high tuberculosis burden country, the potential of Mycobacterium tuberculosis transmission to health care workers is high. This includes diagnostic radiographers and other radiology staff working in radiolo
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