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Bortolloti, Ligia Franciele. "Adaptação transcultural e avaliação das propriedades psicométricas da moorong self efficacy scale (MSES) para a língua portuguesa e cultura brasileira : MSES ? Brasil". Universidade Estadual de Londrina, Universidade Norte do Paraná. Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Reabilitação, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000193118.
Texto completoIntroduction: spinal cord injury (SCI) is one of the greatest physical and emotional challenges that human beings can cope with devastating changes to the physical functioning of the individual, independence, social roles, professional and sexual, and lifestyle. Psychological variables are well recognized to influence health outcomes after SCI, a variable that has been the subject of recent studies regarding health outcomes in people with a range of medical conditions is self-efficacy. The Moorong Self- Efficacy Scale (MSES) is a scale that assesses a number of specific self-efficacy in individuals with SCI items. Objective: to conduct a cross-cultural adaptation and evaluation of the psychometric properties of the MSES for the Portuguese language and Brazilian culture in a sample of patients with SCI, and the evaluation of the psychometric properties involves reproducibility (intra and inter-observer reliability), construct validity (correlation with Medical Outcomes Study 36 Item from Health Survey - SF-36 and the Functional Independence Measure - FIM) and responsiveness (3 and 6 months). Method: 10 subjects participated in the stage for cultural adaptation and to the stage of evaluation of the psychometric properties were 72. Intra and inter- observer reliability was conducted with the first 20 patients. In the initial evaluation MSES was applied by the researcher and a second interviewer 15 minutes later, yielding the inter-observer reliability. After 5-7 days MSES - Brazil was again applied by the researcher and it got to intra-observer assessment. All 72 patients were interviewed in the initial rating, beyond the MSES - Brazil, with the SF-36 and FIM for the assessment of construct validity. After 3 and 6 months of the initial evaluation 72 patients were reevaluated with the MSES - Brazil for obtaining responsiveness. Results: the cross-cultural adaptation generated MSES - Brazil version that had the same number of items, areas, allocation of items, format and response patterns of the original version. The intra-observer reproducibility had an ICC of 0.97 and inter 0.98. Internal consistency in the initial application time was 0.835, after 3 months was 0.890 and 6 months later the Cronbachs α was 0.880. There was no ceiling and floor effects. Correlations of construct validity (rho) were obtained in physical functioning domain of the SF-36 and self-care, transfers, motor and total FIM score. Responsiveness limitations presented during follow-up (P=0.865). Conclusion: the MSES - Brazil showed acceptable psychometric measures, showing that is a scale with good internal consistency, reproducibility, validity, and a tool for rapid administration and easy to understand.
Quea, Camila, Karla Sánchez, David Mauricio, Carlos Raymundo y Francisco Dominguez. "Agile and sustainable methods to implement 6S in textile manufacturing MSEs". International Institute of Informatics and Systemics, IIIS, 2019. http://hdl.handle.net/10757/656358.
Texto completoMejia, Katherine, Henry Quintanilla, Carlos Cespedes, Jose Rojas y Carlos Raymundo. "Application of a management model based on DMAIC methodology to an MSE in the personal beauty sector to increase profitability". Springer Verlag, 2020. http://hdl.handle.net/10757/656357.
Texto completoMicro and Small Enterprise (MSEs) are the primary employment driving force in Peru; however, their low level of management does not allow for their long-term sustainable development. This situation has led such companies to incur unnecessary costs and expenses. In this study, we deal with the case study of a microenterprise of services in the personal beauty sector, which applied a Management Model based on define, measure, analyze, improve, and control (DMAIC) method. That excellent methodology helps to improve processes through the philosophy of continuous improvement, with the aim of proposing improvements to increase profitability and growth. Moreover, the integration of various techniques and tools at each stage of the DMAIC methodology was proposed with a focus on human management processes, inventories, and operational services, which have greater impact on most companies of this type.
Perlacios, Edward, Alexandra Astete, Fernando Sotelo, Carlos Raymundo y Francisco Dominguez. "Management model for the improvement of logistics productivity in pecan producing MSEs in Ica". International Institute of Informatics and Systemics, IIIS, 2019. http://hdl.handle.net/10757/656254.
Texto completoEl propósito de este documento de investigación es proponer un modelo de gestión logística en Mypes productoras de pecana ubicadas en el departamento de Ica, Perú, para esto se realizó un censo a un total de 18 huertos. Este estudio analiza el ámbito de la productividad de las pecanas peruanas en Ica. El modelo es presentado en dos partes: el diagnóstico de las Mypes productoras de pecana en relación al proceso logístico donde se muestran las deficiencias y brechas existentes en comparación con países productores con mayor experiencia y antigüedad en el rubro; así mismo se presenta la propuesta del modelo logístico el cual es desglosado en 3 subprocesos: subproceso de compras, almacenado de materia prima e insumos y almacenado de producto terminado. El desarrollo de los subprocesos se realizó a través de herramientas de gestión por procesos y buenas prácticas logísticas. El principal aporte de la investigación es proponer un modelo en el cual el agricultor pueda adoptar las buenas prácticas, utilizar los indicadores y procedimientos propuestos para tener un control del proceso logístico. El modelo se validó mediante el juicio de expertos y posterior simulación.
Campana, Mateus Betanho 1978. "Tradução, adaptação cultural e validação da escala Moorong Self-Efficacy Scale (MSES) para o português no Brasil = Translation, cultural adaptation and validation of Moorong Self-Efficacy Scale (MSES) into Brazilian Portuguese". [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/275097.
Texto completoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Educação Física
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Resumo: A Lesão da Medula Espinhal (LME) e considerada uma das mais graves incapacidades que podem acometer uma pessoal, podendo causar complicações motoras, sensitivas, metabólicas e psicossociais. Auto-eficácias, que pode ser definida como a convicção que uma pessoa tem em poder realizar certos comportamentos, e um dos fatores que auxiliam no processo de reabilitação da pessoa com LME na medida em que o convívio com outras pessoas que passam por situação semelhante promove a troca de informações e experiências e a imagem de incapacidade vai se transformando em uma imagem de potencialidade e produtividade, frente às experiências motoras significativas vivenciadas nesse novo corpo, alem de reduzir a morbidade e a mortalidade por doenças secundaria decorrentes da LME. O objetivo desse estudo foi trazer para o contexto brasileiro um instrumento de medida para avaliar a Auto-eficácias numa população de pessoas com LME no Brasil. Para isso traduzimos, adaptamos culturalmente e validamos a Moorong Self-Efficacy Scale (MSES) para o português no Brasil através da Analise Fatorial Exploratória. O processo de tradução e adaptação cultural seguiu as recomendações do guideline proposto por Beaton, Bombardier e Guillemin (2002). A partir da validação da MSES, que ocorreu através da Analise Fatorial Exploratória numa amostra não probabilística de 71 sujeitos com LME, pudemos encontrar uma solução composta por 4 fatores que explicavam 65,25% da variância da escala. Acreditamos que a versão em português do Brasil da MSES possa ser utilizada em uma população de homens que praticam atividade física regular, podendo contribuir para que haja um melhor juízo sobre a Auto-eficácias das pessoas com LME no Brasil. Recomendamos que a escala devesse passar por outros processos de validação para ser utilizada em outras populações, como homens e mulheres não praticantes de atividade física
Abstract: Spinal Cord Injury (SCI) is considered one of the most severe disabilities that can affect a person, and may cause motor, sensory, metabolic and psychosocial dysfunctions. Self-efficacy, which can be defined as the belief that a person has to be able to perform certain behaviors, is one of the factors that assist in the rehabilitation of people with SCI once that the socializing with others who go through similar situation promotes the exchange of information and experience and the image of disability is transformed into an image of potentiality and productivity in the face of significant motor experiences lived in this new body, reducing morbidity and mortality from secondary diseases resulting from SCI. The aim of this study was to bring to the Brazilian context a measurement tool to assess Self-Efficacy in a population of persons with SCI in Brazil. For that we translate, culturally adapted and validated the Moorong Self-Efficacy Scale (MSES) to Brazilian Portuguese through an Exploratory Factor Analysis. The process of translation and cultural adaptation followed the guideline proposed by Beaton, Bombardier and Guillemin (2002). From the validation of MSES, which occurred through Exploratory Factor Analysis in a non-probabilistic sample of 71 subjects with SCI, we found a solution composed by 4 factors that explained 65.25% of scale's variance. We believe that the Brazilian version of MSES MSEs can be used in a population of men who have regular physical activity, helping to have a better judgment on the Self-Efficacy of people with SCI in Brazil. We recommend that the scale should go through other processes of validation for use in other populations, such as men and women are not physically active
Doutorado
Atividade Fisica Adaptada
Doutor em Educação Física
Belo, Teresa Freitas. "The relevance of microcredit and its impact om East Timor MSEs and proverty reduction". Doctoral thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/25451.
Texto completoNgatia, Ndiritu. "The influence of Micro-Finance Institutions (MFIs) on Micro and Small Enterprises (MSEs) in Kenya". Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1009436.
Texto completoAlvarado, Lizeth, Juan Díaz, Juan Quiroz y Carlos Raymundo. "Basic production planning and control model based on process management to increase the productivity of mango MSEs in Casma". Springer Verlag, 2020. http://hdl.handle.net/10757/656119.
Texto completoThe department with the greatest economic dependence on the fruit is Ancash, and the Province of Casma is most important in production, as it only produces mango; however, at the productivity level, is a marked difference of 8.2 t/ha compared to the highest worldwide producer, Mexico. Taking this data into consideration, an analysis of the MSEs producing mango in Casma was conducted and problems were seen in the management of resources and processes, both at the levels of planning and control. Considering the problems of MSEs from Casma, a basic Production Planning and Control model was designed based on Process Management and agricultural best practices. The model consists of applying process management tools, such as the flow diagram, the SIPOC turtle, data sheet indicators, procedures, and formats for each sub-process, all with the aim of better understanding the proposal’s development and increasing the productivity of MSEs.
Wong, Edgar, Gianpierre Pajuelo, Fernando Sotelo y Carlos Raymundo. "Implementation of a quality management system (QMS) based on TQM principles for Cocoa MSEs: A case study in Cusco, Perú". Springer Verlag, 2020. http://hdl.handle.net/10757/656137.
Texto completoThe objective of this work is to develop a quality management system focused on the principles of TQM for cocoa micro and small enterprises (MSEs) in the province of La Convención, Cusco - Perú. The diagnosis for this investigation was made using in-depth interviews to the cocoa farmers that facilitated the identification of the current situation of cocoa MSEs. With the results obtained and based on the scientific articles studied, the critical elements in each activity related to the cocoa production process were determined, and it is focused on establishing a quality management system adaptable to the requirements of the plots studied. As a result of the analysis of the experts, the system in question is based on the following principles of TQM: documentation, customer focus, process-based approach and continuous improvement.
Flores-Andrade, K., R. Guardia-Miranda, P. Castro-Rangel, C. Raymundo-Ibañez y M. Perez. "Production management model through MPS and line balancing to reduce the non-fulfillment of orders in lingerie clothing MSEs in Peru". Institute of Physics Publishing, 2020. http://hdl.handle.net/10757/656404.
Texto completoEkblom, Mikaela. "Challenges Facing Food Processing MSEs in Tanzania : A Qualitative Case Study of the Sunflower Oil Industry in Babati, Manyara". Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-30289.
Texto completoIvaneyko, Dmytro, Vladimir Toshchevikov, Marina Saphiannikova y Gert Heinrich. "Mechanical properties of magneto-sensitive elastomers: unification of the continuummechanics and microscopic theoretical approaches". Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36394.
Texto completoAtiase, Victor Yawo. "The impact of FNGO services on the performance of micro and small enterprises : empirical evidence from the Volta Region, Ghana". Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621812.
Texto completoMunroe, Mary K. "The Association Between Child Maltreatment and Adult Revictimization: The Contribution of Early Maladaptive Schemas". Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1398691144.
Texto completoBarboza, José Vinícius Santos. "Análise das micro e pequenas empresas e produtores do segmento agronegócio participantes do prêmio MPE Brasil noEstado do Paraná". Universidade Estadual do Oeste do Parana, 2016. http://tede.unioeste.br:8080/tede/handle/tede/845.
Texto completoMicro and Small Enterprises (MSEs) as well as the Rural Enterprise have great relevance in a regional context. The research aimed to analyze the profile of 121 MPE Brazil Award (Competitiveness Award for Micro and Small Enterprises) in the agribusiness category which is represented by 32% companies and 82% rural producers. Through an exploratory analysis was possible to identify a global overview of the criteria and their respective performances in Leadership (45%), Strategies and Plans (33%), Customers (37%), Society (42%), Information and Knowledge (44 %) People (35%), Processes (45%) and Results (3%). After, data mining techniques were used for analysis by groups; the participants were grouped into four clusters due to their similar characteristics, highlighting the Leadership and Processes criteria with the highest average among all of the criteria. Finally, a detailed analysis by criterion of Excellence was carried out as a way to deepen the results and diagnose the main factors that influence the outcome. It was highlighted some critical factors such as the definition of mission and vision, definition of functions, standardization of processes, availability of information, lack of customer satisfaction assessment, control and then the performance in the social sphere by the entrepreneurs. For these critical factors has been proposed an action plan for results improvement. Among the activities are the executions of courses and workshops, development of management tools, dissemination of good practices, among others. It is suggested the support of entities such as the Sebrae (Brazilian Micro and Small Business Support Service), Senar (Brazilian National Rural Learning Service) and universities. The results show that, as in the literature analyzed, both farmers and micro and small businesses have in common the difficulty in management, development of strategies and management practices. At the same time, there is an increased demand for support services
As Micro e Pequenas Empresas (MPEs) assim como os Empreendimentos Rurais têm grande relevância no cenário regional. A pesquisa objetivou analisar o perfil dos 121 participantes paranaenses do Prêmio MPE Brasil - Prêmio de Competitividade para Micro e Pequenas Empresas, do segmento agronegócio sendo a população representada por 32% empresas e 82% produtores rurais. Por meio de uma análise exploratória foi possível identificar um panorama global dos critérios e os seus respectivos desempenhos (Liderança (45%), Estratégias e Planos (33%), Clientes (37%), Sociedade (42%), Informação e conhecimento (44%), Pessoas (35%), Processos (45%) e Resultado (3%)). Após, foram utilizadas técnicas de data mining (mineração de dados) para uma análise por agrupamentos, sendo os participantes agrupados em quatro clusters por apresentarem características semelhantes, destacando-se os critérios de Liderança e Processos com as maiores médias entre os critérios. Por fim, uma análise detalhada por critério de excelência foi realizada como forma de aprofundar os resultados e diagnosticar os principais fatores que influenciam no resultado. Destacaram-se alguns fatores críticos como a definição da missão e visão, definição de funções, padronização de processos, disponibilidade de informações, ausência de avaliação de satisfação de clientes, controle e por fim atuação no âmbito social por parte dos empreendedores. Para esses fatores críticos foi proposto um plano de ação para que os resultados sejam melhorados. Entre as ações estão a realização de cursos e oficinas, desenvolvimento de ferramentas de gestão, divulgação de boas práticas, entre outros. Sugere-se o apoio de órgãos como exemplo o Sebrae, Senar e Universidades. Os resultados demonstram que, assim como na literatura analisada, os produtores rurais e as micro e pequenas empresas, possuem como característica comum a dificuldade na gestão, na elaboração de estratégias e a práticas administrativas. Ao mesmo tempo ocorre uma procura crescente dos pequenos empreendimentos aos órgãos de apoio.
Freiberg, Jill Maree y n/a. "Topical Talk in General Practice Medical Consultations: The Operation of Service Topics in the Constitution of Orderly Tasks, Patients and Service Providers". Griffith University. School of Cognition, Language and Special Education, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041012.125934.
Texto completoFreiberg, Jill Maree. "Topical Talk in General Practice Medical Consultations: The Operation of Service Topics in the Constitution of Orderly Tasks, Patients and Service Providers". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/366054.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Cognition, Language and Special Education
Faculty of Education
Full Text
Agreda, Chavez Isabel Roxana. "Propuesta de una gestión por procesos de recursos humanos que permita incrementar la competitividad y productividad de las micro y pequeñas empresas del subsector elaboración y conservación de frutas, hortalizas y legumbres en Lima Metropolitana". Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/657326.
Texto completoThis thesis presents a management by processes model of human resources adapted to Micro and Small Enterprises (MSEs) dedicated to the elaboration and conservation of fruits, vegetables, and legumes of Metropolitan Lima. The research was carried out on 41 Micro and Small Enterprises (MSEs) to improve the identification of the difficult situation these companies are going through in terms of human resources, which has been in charge of limiting their sustainability over time and promoting staff rotation. The proposal will allow Micro and Small Enterprises (MSEs) to have the necessary documentation, tools, procedures, and formats to enhance the company's main asset to increase its productivity and competitiveness. The model includes the processes of personnel planning, hiring, training, termination, compensation, and performance evaluation. The validation of the proposal was carried out by experts in management by processes, human resources, and Micro and Small enterprises (MSEs), who, through the qualification granted, determined the viability of the project.
Tesis
Lamboni, Matieyendou. "Analyse de sensibilité pour les modèles dynamiques utilisés en agronomie et environnement". AgroParisTech, 2009. http://www.theses.fr/2009AGPT0087.
Texto completoCunha, Reynaldo Dannecker. "A influência das atividades de marketing na performance de exportação em países emergentes: um estudo sobre micro e pequenas empresas brasileiras". Associação Escola Superior de Propaganda e Marketing, 2012. http://tede2.espm.br/handle/tede/53.
Texto completoThis study analyzes the influence of marketing activities in the internationalization process of micro and small enterprises (MSEs) in emerging countries, focusing on export operations carried out by Brazilian companies. The overall objective is to analyze these activities and check its impact on export performance of MSEs. The specific objectives involve the evaluation of adaptation-standardization strategies, considering the marketing mix (product, price, communication and distribution) on foreign markets; the export performance and its relevance to their business success. To that end, it was developed a conceptual framework that examines company and products characteristics, entrepreneurial marketing and how they influence the marketing activities in the export process. The model is based on a conceptual analysis on export marketing strategy (EMS) and export performance developed by Cavusgil and Zou (1994). In order to understand the context, a comprehensive theoretical review evaluated theories of globalization, marketing and the historical performance of micro and small enterprises in Brazilian exportation. To test the hypothesis a survey was performed with 173 MSEs available at SEBRAE, ABICALÇADOS and Serasa Experian databases; data were analyzed using descriptive and multivariate statistics by structural equation modeling (SEM). It was possible to detect the importance of EMS in the export performance of MSEs studied, mainly by adapting the price to the target market, making it more competitive. It was identified the critical role of international competence of the company for greater success in exporting, as well as the indirect influence of entrepreneurial marketing in export performance, through the impact on EMS. As contributions, the development of the conceptual model adapted to MSEs improves Cavusgil and Zou (1994) model, because this has been tested only in large companies, filling therefore an empirical gap. In addition, studying the export performance of MSEs is aligned with the importance of such company for the Brazilian economy, and the diagnosis on export performance of the same, from economic and strategic criteria, not only contributes to managerial decisions, but to government policies.
Este estudo analisa a influência das atividades de marketing na internacionalização de micro e pequenas empresas (MPEs) em países emergentes, com foco nas operações de exportação desenvolvidas por empresas brasileiras. O objetivo geral é analisar essas atividades e verificar seu impacto na performance de exportação das MPEs. Os objetivos específicos envolvem a avaliação da estratégia de adaptação versus a de padronização, sendo abordado o composto de marketing (produto, preço, comunicação e distribuição) com vistas a mercados externos; a performance de exportação e sua relevância para o sucesso das empresas. Para tanto, foi elaborado um modelo conceitual que analisa as características da empresa, características de seus produtos e o marketing empreendedor, e como estas influenciam as atividades de marketing nos processos de exportação. O modelo está baseado na análise conceitual sobre estratégia de marketing para exportação (EMS) e performance de exportação construído por Cavusgil e Zou (1994). Para contextualizar o campo de estudo, realizou-se uma revisão teórica sobre teorias de internacionalização, sobre marketing e sobre o desempenho histórico das micro e pequenas empresas brasileiras na exportação. Para testar as hipóteses foi realizada uma survey com 173 MPEs oriundas de bases de dados do SEBRAE, da ABICALÇADOS e da Serasa Experian, e os dados obtidos foram analisados utilizando-se estatística descritiva e multivariada, por meio da modelagem de equações estruturais (SEM). Foi possível detectar a importância das EMS na performance de exportação das MPEs estudadas, principalmente pela adaptação do preço ao mercado de destino, tornando-o mais competitivo. Identificou-se o papel decisivo da competência internacional da empresa para obter maior sucesso na exportação, assim como da influência indireta do marketing empreendedor na performance de exportação, por meio dos impactos nas EMS. Como contribuições, a elaboração do modelo conceitual adaptado a MPEs apresenta uma evolução do modelo de Cavusgil e Zou (1994), pois este foi testado apenas em grandes empresas, preenchendo, portanto, um gap empírico. Além disso, estudar a performance de exportação das MPEs está alinhado com a importância desse tipo de empresa para a economia brasileira, e o diagnóstico sobre desempenho de exportação das mesmas, a partir de critérios econômicos e estratégicos, contribui para decisões não apenas gerencias, mas para as políticas do Governo.
Oliveira, Francisco Wildys de. "ContribuiÃÃes da Lei geral das MPEs para a formaÃÃo de empregos no Brasil: uma anÃlise sobre a indÃstria de transformaÃÃo". Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16226.
Texto completoEsta pesquisa analisa os impactos da polÃtica pÃblica de incentivo Ãs MPEs (introduzida no Brasil atravÃs da Lei Complementar n 123, de 2006) na geraÃÃo de emprego e renda na indÃstria de transformaÃÃo entre os anos de 2006 a 2011. Discorre sobre as experiÃncias nacionais e internacionais de incentivo Ãs MPEs e dà Ãnfase ao incremento da participaÃÃo dos pequenos negÃcios na economia nacional como gerador de emprego e renda. O trabalho baseia-se em pesquisa bibliogrÃfica e em dados sobre o nÃmero de estabelecimentos da indÃstria de transformaÃÃo, de acordo com a CNAE 2.0 do IBGE, bem como pessoal ocupado assalariado no banco de dados do IBGE de acordo com o cadastro geral de empresas. Com a finalidade de medir a repercussÃo da Lei Geral na criaÃÃo de empresas e no nÃmero de trabalhadores assalariados nos estados brasileiros, utilizou-se o mÃtodo de diferenÃa em diferenÃas, que à bastante utilizado na avaliaÃÃo de programas de polÃticas pÃblicas dessa natureza. Os resultados sugerem que o impacto na Lei Geral no aumento do nÃmero de estabelecimentos nÃo foi satisfatÃrio, ou seja, houve decrÃscimos de estabelecimentos ME e a quantidade de EPP nÃo foi estatisticamente significante. Constatou-se tambÃm igual efeito do Estatuto das MPEs no nÃmero de trabalhadores assalariados no setor da indÃstria de transformaÃÃo.
This research analyzes the impact of public policy of encouraging MSEs (introduced in Brazil by Complementary Law No. 123, 2006) in generating employment and income in the manufacturing industry between the years 2006 to 2011. Discourses on national experiences and International incentive to MSEs and emphasizes the increased participation of small businesses in the national economy as employment and income generator. The work is based on literature research and data on the number of establishments in the manufacturing industry, according to NCEA 2.0 IBGE, as well as employed persons in the database according to the IBGE of the general business register. In order to measure the impact the General Law on job training and the number of enterprises in the Brazilian states, we used the difference in differences method, which is widely used in the evaluation of public policies such programs. The results suggest that the impact on the General Law on increasing the number of stores was not satisfactory, ie there was a decrease of ME establishments and the amount of EPP was not statistically significant. We also observed the same effect of the Statute of MSEs in the number of employees in the manufacturing sector.
Braga, Juliana Cardoso. "Projeto Caco". Doctoral thesis, Universidade de Lisboa, Faculdade de Arquitetura; Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Arquitetura, Artes e Comuniucação, 2019. http://hdl.handle.net/10400.5/18170.
Texto completoA maior parte das empresas moveleiras existentes no Brasil (97%) são constituídas por Micro e Pequenas Empresas (MPEs). A produção é essencialmente de móveis produzidos por encomenda e sob medida e empregam processos de fabricação semi-artesanais. Os processos de produção não são sustentáveis, o que se traduz em desperdícios e em um grande volume de resíduos. Os resíduos compostos, principalmente, por restos de madeira reconstituída (principalmente de MDF) muitas vezes são eliminados de modo irregular no espaço público, queimados a céu-aberto ou em fornos de padaria. O descarte irregular de resíduos constitui uma ameaça para a saúde pública e para o ambiente, degrada a imagem das periferias e acentua as assimetrias sociais. As ações de fiscalização e de penalização têm sido ineficazes, pelo que urge repensar o problema envolvendo a geração e a disposição de resíduos dessas empresas. A “pulverização” de MPEs do setor por um território muito vasto e a reduzida dimensão dessas estruturas produtivas têm dificultado as ações de sensibilização para uma mudança do paradigma produtivo, porque essas empresas estão, na sua maioria, demasiado preocupadas com a sua subsistência. Essa investigação objetivou identificar e minimizar os desperdícios e o descarte irregular de resíduos por parte das MPEs moveleiras, reduzindo os impactos ambientais, econômicos e sociais provenientes da produção de mobiliário personalizado por meio do design estratégico sustentável. Em termos metodológicos, foi utilizada a Investigação Ativa (Active Research), integrada com um processo participativo entre os stakeholders. O estudo de campo conduziu-se em um contexto local, na região do Triângulo Mineiro, Minas Gerais, Brasil. A partir do diagnóstico realizado em cinco MPEs de mobiliário personalizado da região foi desenvolvido um modelo que propõe a melhoria contínua de produtos, serviços e processos produtivos por meio de um conjunto de estratégias, diretrizes e ferramentas de design estratégico sustentáveis que podem ser implementadas de maneira progressiva. O modelo foi avaliado por um painel de dez especialistas e um plano de ação foi determinado visando sua inserção em uma empresa piloto. O modelo designado Projeto Caco foi parcialmente implementado em uma MPE de mobiliário. Como resultado parcial da investigação verificou-se que em consequência da estratégia de negociação e articulação de interesses públicos e privados promovida pelo Projeto Caco, 60 marcenarias da região do Triângulo Mineiro passaram a destinar os resíduos de modo ambientalmente correto em um aterro industrial licenciado. Os resultados demonstraram que o modelo é um recurso para reduzir os desperdícios e os impactos sociais, ambientais e econômicos das MPEs moveleiras, para incentivar a destinação correta de resíduos, reduzir a degradação do espaço público, gerar economia aos cofres públicos municipais e reduzir os impactos para a sociedade afetada pelo descarte irregular de resíduos.
ABSTRACT: Most of the furniture companies in Brazil (97%) are Small and Medium-sized Enterprises (MSEs). The production is essentially made-to-order and custom-made furniture and applies semi-craft manufacturing processes. Production processes are not sustainable, resulting in waste and a large volume of waste. Residues composed mainly of reconstituted wood residues (mainly MDF) are often disposed irregularly in the public space, burnt in open skies or in bakery ovens. Irregular waste disposal poses a threat to public health and the environment, degrades the image of the peripheries and accentuates social asymmetries. The inspection and penalty actions have been ineffective, so it is urgent to rethink the problem involving the generation and disposal of waste from these companies. The "spraying" of MSEs in the sector over a very wide territory and the small size of these productive structures have made it difficult to raise awareness of a change in the productive paradigm because these companies are, for the most part, too preoccupied with their subsistence. The objective of this investigation was to identify and minimize the waste and the irregular disposal of waste by furniture MSEs, reducing the environmental, economic and social impacts from the production of customized furniture through sustainable strategic design. In methodological terms, Active Research was used, integrated with a participatory process among stakeholders. The field study was conducted in a local context, in the region of Triângulo Mineiro, Minas Gerais, Brazil. Based on the diagnosis made in five MSEs of customized furniture in the region, a sustainable strategic design model was developed, consisting of a set of strategies, guidelines and tools, which proposes the progressive improvement of products, services and production processes. The model was evaluated by a panel of ten experts and a plan of action was determined aiming its insertion in a pilot company. The model named Project Caco was partially implemented in a furniture MSE. As a partial result of the investigation, it was verified that as a consequence of the strategy of negotiation and articulation of public and private interests promoted by the Caco Project, 60 woodworkers from the region of the Triângulo Mineiro began to direct the waste in an environmentally correct way in a licensed industrial landfill. The results demonstrated that the model is a resource to reduce the waste and social, environmental and economic impacts of the MSEs, to encourage the correct disposal of waste, reduce public space degradation, generate savings to municipal public coffers and reduce impacts to the society affected by the irregular waste disposal.
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Ballard, B., T. Degnan, M. Kipp, J. Johnson, D. Miller y M. Minto. "Mine Safety Detection System (MSDS)". Thesis, Monterey, California. Naval Postgraduate School, 2012. http://hdl.handle.net/10945/17457.
Texto completoApproved for public release, distribution unlimited
The search, detection, identification and assessment components of the U.S. Navys organic modular in-stride Mine Countermeasure (MCM) Concept of Operations (CONOPS) have been evaluated for their effectiveness as part of a hypothetical exercise in response to the existence of sea mines placed in the sea lanes of the Strait of Hormuz. The current MCM CONOPS has been shown to be capable of supporting the mine search and detection effort component allocation needs by utilizing two Airborne Mine Countermeasure (AMCM) deployed systems. This adequacy assessment is tenuous. The CONOPS relies heavily upon the Sikorsky MH- 60/S as the sole platform from which the systems operate. This reliance is further compounded by the fact both AMCM systems are not simultaneously compatible on board the MH-60/S. As such, resource availability will challenge the MCM CONOPS as well as the other missions for which the MH-60/S is intended. Additionally, the AMCM CONOPS systems are dependent upon the presence of warfighters in the helicopters above the minefield and as integral participants in the efforts to identify sea mines and to assess their threat level. Model Based System Engineering (MBSE) techniques have been combined with research and stakeholder inputs in an analysis that supports these assertions.m
Hompis, George-Sigfrid. "Studentens Krisberedskap efter MSBs informationsblad". Thesis, Karlstads universitet, Institutionen för hälsovetenskaper (from 2013), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-75406.
Texto completoThe society stands for different kind of crisis and the citizens doesn’t seem to have enough preparation. Municipalities and authorities do play a crucial role for the resident’s safety when a crisis occur but at the same time the residents have their own responsibility regarding preparation for eventual crisis that may occur. MSB year 2018 got a mission from the government to distribute an information flyer to the public for to be able to raze their knowledge about crisis preparation. The information flyer would work as a tool for the public for to be able to take responsibility in a crisis. The purpose of this paper is to examine how students experience that their crisis preparations and which factors affect theirs preparation to a potential crisis. The data has been collected through interviews with students who received the information flyer and the data material has be analyzed with a quality content analysis. The results showed that the information flyer had a little impact on the students interest of purchasing preparedness kit but on the other hand the students had started to get thoughts of preparedness and crisis. Information is a very strong component for the student’s preparedness, but also the students do have a knowledge which regard own responsibility if a crisis should occur. The main responsibility though lays as the students tell on the authorities for the civilian’s safety but also the information which is sent out to them. Beside that the students consider that the civilians have also an own responsibility to make sure that they get the information sent to them from the authorities and the municipalities. As the students say there must be a cooperation between the authorities and the residents. Beside that the students consider that the information which is sent must needs to be obtained from different kind of sources of the media for to be able to get a correct and full information of a situation. Moreover, the student’s surroundings can affect their crisis preparedness due to family and friends. Handling medicine is something that is pointed out the information flyer didn’t include. Some medicines need to be chilled and thus also the it is considered that this question is important. The students mean that the information flyer needs to be more specific for to cover this and have a wider benefit. Leadership is also something that the students see as important due to many of them doesn’t know how or what to do if a crisis should occur. This study could be generalized and affect more respondents beside students. Individuals in many different situations could reflect themselves in the situation the students in the study are in.
Reyes, Angulo Fabrizio y Zevallos Alejandra Paola Muñante. "Propuesta de un modelo de un proceso de gestión de la producción basado en gestión por procesos y buenas prácticas en las MyPes productoras de pecanas en Ica- Pachacutec con la finalidad de incrementar la productividad". Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/653634.
Texto completoThis study proposes a model of a Production Management process based on good practices and developed with process management tools in order to increase the productivity of Pecan crops in Ica region - Pachacútec district as an area study. This study covers the diagnosis and development of the proposed model. The relationship between these stages is the main function for improving the productivity of pecan orchards. With the study carried out it was shown that to increase the productivity of pecans from 0.9 (tn / ha) to 1.40 (tn / ha), as well as to be able to determine the needs of raw material, instruments and / or labor, a standardized pecan production process. The limitations in the study region tend to be accessibility to resources, the number of people that make up the MSEs and their level of study. The main contribution of the research is the proposed pecan nut model, which is based on 3 parts: production planning, production scheduling and production control. The planning of the production will be in charge of carrying out a planning of resources of the micro and small pecan companies in Peru; the production scheduling will be based on the realization of a production resource schedule and the production control will be focused on a control based on cards to keep a basic record for these companies.
Tesis
Abdalla, Mohamed Musa. "Automatic generation of SDL specifications from MSCs". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0017/MQ47822.pdf.
Texto completoLi, Zhaoqiang. "Specification and detection of feature interactions using MSCs". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ47827.pdf.
Texto completoFerreira, Daniela Filipa Alves. "Influence of substrates composition on immunomodulation by MSCs". Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16048.
Texto completoMesenchymal stem cells (MSCs) are non-hematopoietic multipotent stem cells capable to self-renew and differentiate along different cell lineages. MSCs can be found in adult tissues and extra embryonic tissues like the umbilical cord matrix/Wharton’s Jelly (WJ). The latter constitute a good source of MSCs, being more naïve and having a higher proliferative potential than MSCs from adult tissues like the bone marrow, turning them more appealing for clinical use. It is clear that MSCs modulate both innate and adaptive immune responses and its immunodulatory effects are wide, extending to T cells and dendritic cells, being therapeutically useful for treatment of immune system disorders. Mechanotransduction is by definition the mechanism by which cells transform mechanical signals translating that information into biochemical and morphological changes. Here, we hypothesize that by culturing WJ-MSCs on distinct substrates with different stiffness and biochemical composition, may influence the immunomodulatory capacity of the cells. Here, we showed that WJ-MSCs cultured on distinct PDMS substrates presented different secretory profiles from cells cultured on regular tissue culture polystyrene plates (TCP), showing higher secretion of several cytokines analysed. Moreover, it was also shown that WJ-MSCs cultured on PDMS substrates seems to possess higher immunomodulatory capabilities and to differentially regulate the functional compartments of T cells when compared to MSCs maintained on TCP. Taken together, our results suggest that elements of mechanotransduction seem to be influencing the immunomodulatory ability of MSCs, as well as their secretory profile. Thus, future strategies will be further explored to better understand these observation and to envisage new in vitro culture conditions for MSCs aiming at distinct therapeutic approaches, namely for immune-mediated disorders.
As células estaminais mesenquimais (MSCs) são células não-hematopoéticas, multipotentes, capazes de se auto-renovar e de diferenciar em diferentes tipos celulares. As MSCs estão presentes em tecidos mesenquimais e de tecidos extra embrionários, tais como a matriz do cordão umbilical/Wharton’s Jelly(WJ). Estes últimos constituem uma boa fonte de de MSCs, sendo estas mais naive e tendo um maior potencial de proliferação do que as MSCs obtidas de tecidos adultos, como a medula óssea, tornando as MSCs da matriz do cordão umbilical/Wharton’s Jelly sejam mais apelativas para uso clínico. As MSCs possuem a capacidade de modularem tanto o sistema imune inato como o adquirido e os seus efeitos são vastos, afectando todas as células do sistema imune. Esta capacidade é bastante vantajosa para o uso terapêutico destas células em doenças do sistema imunitário. A mecanotransducção é por definição o mecanismos pelo qual as células convertem estímulos mecânicos em uma resposta bioquímica e com mudanças na sua morfologia. Apartir destas observações colocámos a hipotese de que mantendo MSCs in vitro em diferentes substratos poderia influencia a sua capacidade imunomoduladora. Com este trabalho, demonstrámos que ao plaquear MSCs em diferentes substratos de PDMS, estas mostram uma tendência para secretar quantidades diferentes de vários factores soluveis analisados, relativamente a MSCs mantidas em cultura em plataformas convencionais (placas de cultura de células - TCP). Para além disto, foi também observado que MSCs plaqueadas em substratos de PDMS aparentavam possuir uma maior capacidade imunomoduladora quando comparadas com MSCs mantidas em condições convencionais. Em conjunto todos os resultados obtidos sugerem que elementos relacionados com a mecanotransdução parecem influenciar a capacidade imunomoduladora de MSCs e a sua secreção de factores solúveis. Deste modo, estudos futuros poderão elucidar os mecanismos responsáveis por estas observações, de modo a permitir que se possa constitutuir melhores estratégias de cultura de MSCs para futuro uso terapêutico dirigido a doenças do sistema imunitário.
Aktas, Metin. "Lse And Mse Optimum Deconvolution". Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605111/index.pdf.
Texto completoHe, Q. "Peripheral blood derived multi-potent mesenchymal stromal cells (MSCs) in rats : their differentiation and characteristic comparison with bone marrow derived MSCs". Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431597.
Texto completoKratzsch, Fabian, Alexander Lorz, Raimar Kempcke y Tjalf Ziemssen. "Integration Touchscreen-basierter Patientenbefragung in das neurologische Dokumentationssystem MSDS". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-142922.
Texto completoBroadmeadow, James, Francis Dziekan, Francis Frantz, Rodney Gudz, Patrick Kelley, Shawn Kennedy, Christine Moreira et al. "Improved Anti-Submarine Warfare (ASW) effectiveness MSSE Capstone Project". Thesis, Monterey, California. Naval Postgraduate School, 2008. http://hdl.handle.net/10945/6934.
Texto completoRydberg, Adam. "Strukturering av ostrukturerade data : En studie av MSBs kundtjänst". Thesis, Karlstads universitet, Handelshögskolan (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-68094.
Texto completoKratzsch, Fabian, Alexander Lorz, Raimar Kempcke y Tjalf Ziemssen. "Integration Touchscreen-basierter Patientenbefragung in das neurologische Dokumentationssystem MSDS". Technische Universität Dresden, 2010. https://tud.qucosa.de/id/qucosa%3A28025.
Texto completoLin, Paul. "Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)". Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1355278573.
Texto completoTauginas, Tadas. "Formalių metodų panaudojimas, kuriant verslo valdymo sistemas MSBS-Navision terpėje". Master's thesis, Lithuanian Academic Libraries Network (LABT), 2004. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2004~D_20040531_224642-51516.
Texto completoBehnan, Jinan. "The Role of Mesenchymal Stem Cells (MSCs) inBrain Tumor Progression". Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-34468.
Texto completoPolepalli, Susheela. "Discovery of core-periphery structures in networks using k-MSTs". University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573573474759435.
Texto completoGaja, Tomáš. "Návrh anténní řady pro MSPS radar pracující v pásmu L". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316426.
Texto completoHuang, Rong. "The role of MSCs in immunoregulation of macrophages during osteogenesis". Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/123512/1/Rong%20Huang%20Thesis.pdf.
Texto completoBingham, Nathanael G. "Passive Resistance of Abutments with MSE Wingwalls". BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3201.
Texto completoLlinàs, Riera Maria del Carme. "New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications". Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/369849.
Texto completoEn la presente tesis doctoral se describe un procedimiento general para la obtención de nanopartículas mesoporosas de sílice (MSNs) regioselectivamente bifuncionalizadas de forma ortogonal con distintos grupos funcionales. La estrategia sintética consiste en la preparación de MSNs mediande co-condensación, seguido de una posterior funcionalización covalente, mientras el tensioactivo se encuentra todavía presente en la estructura de las MSNs. Siguiendo esta metodología, se han sintetizado las nanopartículas bifuncionalizadas amina-azida (MSN-(NH2)i(N3)o), amina-isotiocianato (MSN-(NH2)i(NCS)o) y amina-aldehído (MSN-(NH2)i(CHO)o), para su uso en aplicaciones biomédicas. En primer lugar, se han sintetizado y caracterizado de forma homogénea y reproducible las nanopartículas aminadas de referencia (MSN-NH2) que permitirán las sucesivas funcionalizaciones, con un tamaño de 50 nm y 100 nm aproximadamente. Estas nanopartículas aminadas se han usado posteriormente para la síntesis de sensores de naftalimida. Se ha conseguido desarrollar un procedimiento general para la introducción de 4-amino-1,8 naftalimidas. Estas naftalimidas han sido probadas como sensores y puertas lógicas para la detección de H + y F-. Por otra parte, se ha descrito un protocolo para preparar amino-azida-MSNs de forma regioselectiva. Estas MSNs han sido funcionalizadas por primera vez con foldámeros catiónicos y su capacidad para cruzar membranas citoplasmáticas y viabilidad ha sido estudiada, así como el uso de estos sistemas para la liberación intracelular de doxorubicina (DOX) de forma controlada. También se ha realizado un nuevo protocolo para preparar MSNs con isotiocianato en su estructura. La metodología sintética es general y puede aplicarse, en principio, a todo tipo de MSNs aminadas. La eficiencia de la funcionalización es comparable a la cicloadición de cobre (CuAAC) evitando los protocolos de aislamiento y de eliminación del metal. Siguiendo esta metodología, se han preparado unas nuevas amino-isotiocianato-MSNs para el diseño de un nano-contenedor capaz de liberar el fármaco Ataluren de forma controlada. Se ha logrado sintetizar amina-aldehído-MSN. Estas MSNs se han aplicado como una nanoplataforma simple y versátil capaz de liberar de forma dual una mezcla CPT/DOX para el tratamiento del cáncer, mediante el uso de estímulos de pH. Mientras un fármaco es absorbido dentro de la superficie interior, el otro está unido covalentemente a la superficie externa, actuando así como fármaco y como agente bloqueante de poro. Este sistema responde a los estímulos de pH y ambos fármacos son solamente liberados en un medio ácido.
In this PhD dissertation, a general procedure for the obtaining of different regioselective orthogonal bifunctionalized mesoporous silica nanoparticles (MSNs) has been carried out. The strategy consists of a covalent functionalization of co-condensed monodispersed and uniform aminated-MSNs, where tensioactive is still present in its structure. Three bifunctionalized MSNs, amine-azide (MSN-(NH2)i(N3)o), amine-isothiocyanate (MSN-(NH2)i(NCS)o) and amine-aldehyde (MSN-(NH2)i(CHO)o), with efficient “click” reactions, have been synthetized for its use in biomedical applications. First, a well characterized batch of precursor aminated-MSNs (MSN-(NH2)) has been prepared. The best conditions for the synthesis of homogenous and reproducible MSN-(NH2) with a size between 50-100 nm have been studied. These aminated-MSNs have been used for the synthesis of naphthalimide sensors where a general procedure for the introduction of 4-amine-1,8-naphthalimides has been developed. These naphthalimides have been tested as potential logic gates for the detection of H+ and F-. A straightforward protocol to prepare amine-azide MSNs has been described. These MSNs have been functionalized with quinolin cationic foldamers for the first time. The ability of these foldamer-MSNs to cross cytoplasmic membranes and its viability has been studied. The penetrating capacity of foldamer-MSNs have been used for intracellular delivery of Doxorubicin (DOX). A new protocol to prepare isothiocyanate functionalized MSNs is described. The synthetic methodology is general and can be applied, in principle, to all type of aminated MSNs. The efficiency of the functionalization is comparable to the copper cycloaddition (CuAAC) avoiding isolation and copper removal protocols. Following this methodology, new amino-isothiocyanate-MSNs have been prepared for the design of a nano-container able to release the drug Ataluren in a controlled manner, for the treatment of Duchenne muscular dystrophy (DMD). Regioselective bifunctionalized amine-aldehyde-MSNs have been synthetized. These MSNs have been applied as a versatile nanoplatform able to release dual synergistic CPT/DOX mixture for cancer treatment only by using pH stimuli. While CPT is absorbed at the inner surface, DOX is covalently linked to the external surface acting both as an active and a capping agent (pH=4).
Schweickert, H. [Verfasser]. "Messung magnetischer Kernmomente kurzlebiger Radionuklide. Beispiel: 408 msec Na²⁰ / H. Schweickert". Karlsruhe : KIT-Bibliothek, 2009. http://d-nb.info/1186905603/34.
Texto completoBarisic, Dominik [Verfasser] y Melanie L. [Akademischer Betreuer] Hart. "Differentiation potential of adult human MSCs into neuro-striated muscle cells". Freiburg : Universität, 2018. http://d-nb.info/1226091318/34.
Texto completoGeraldo, Ângela Margarida Ferreiro. "Substrates effect on Mesenchymal Stem Cells (MSCs) secretome and cellular subproteome". Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16394.
Texto completoMesenchymal stem cells (MSCs) are adult multipotent cells that possess self-renewal capacity, have a high proliferative ability and are able to differentiate into mesodermal cell types. MSCs can be isolated from mesenchymal and extraembryonic tissues such as the umbilical cord matrix. The latter constitutes an attractive and alternative source of MSCs since these cells seem to be more naïve and possess higher proliferation capacity. In vivo, MSCs reside in a specialized microenvironment that is essential for the regulation of signaling, proliferation, migration and differentiation. Through mechanotransduction, mechanical forces of microenvironment are transduced into biochemical responses, which can lead to alterations in phenotype and lineage-specific differentiation, and changes in protein synthesis of MSCs. Based on these observations, this study aimed at exploring the effect of physical and biochemical substrate composition on the secretome and cellular subproteomes of MSCs derived from umbilical cord matrix. The present study revealed the modulation of the secretome and cellular subproteome profiles (soluble and membrane fractions) of MSCs cultured on soft substrates, with several proteins being modulated, namely the up-regulation of antioxidant proteins. Hence, we propose that MSCs cultured on soft substrates may constitute a population of cells with increased antioxidant properties, in principle allowing the cells to cope better with the stressful and hostile environments that they may encounter in vivo in a transplantation context.
As células estaminais mesenquimais (MSCs) são células estaminais adultas, multipotentes, capazes de se auto-renovar e diferenciar em diferentes tipos celulares mesodermais. O isolamento destas células pode ser feito a partir tecidos mesenquimais, bem como de extra embrionários, como por exemplo da matriz do cordão umbilical. Este último constitui uma fonte alternativa e atrativa de MSCs uma vez que estas apresentam características mais naïve e uma maior taxa de proliferação. In vivo, as células mesenquimais têm um microambiente especializado que é essencial à regulação da sinalização, proliferação, migração e diferenciação celular. Através da mecanotransdução, as forças mecânicas do ambiente extracelular são traduzidas em respostas bioquímicas que podem conduzir à alteração de fenótipo e diferenciação em diferentes tipos celulares e, além disso, à alteração da síntese de proteínas. A partir destas observações, este trabalho teve como objetivo o estudo do efeito das propriedades do substrato, tais como a rigidez e composição bioquímica, no secretoma e subproteomas de células estaminais mesenquimais isoladas a partir da matriz do cordão umbilical. Este estudo revelou uma modulação do secretoma e subproteomas celulares (frações solúvel e membranar) quando as MSCs foram mantidas em cultura sobre substratos com menor rigidez, demonstrando a modulação de múltiplas proteínas e nomeadamente o aumento dos níveis de proteínas anti-oxidantes. Deste modo, propomos que células cultivadas em substratos com menor rigidez possuam uma maior atividade anti-oxidante, o que irá permitir que estas apresentem uma melhor resposta face a ambientes hostis in vivo num contexto de transplantação.
Dong, Jun. "MSWs gasification with emphasis on energy, environment and life cycle assessment". Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2016. http://www.theses.fr/2016EMAC0017/document.
Texto completoDue to the potential benefits in achieving lower environmental emissions and higher energy efficiency, municipal solid waste (MSW) pyro-gasification has gained increasing attentions in the last years. To develop such an integrated and sustainable MSW treatment system, this dissertation mainly focuses on developing MSW pyro-gasification technique, including both experimental-based technological investigation and assessment modeling. Four of the most typical MSW components (wood, paper, food waste and plastic) are pyro-gasified in a fluidized bed reactor under N2, steam or CO2 atmosphere. Single-component and multi-components mixture have been investigated to characterize interactions regarding the high-quality syngas production. The presence of plastic in MSW positively impacts the volume of gas produced as well as its H2 content. Steam clearly increased the syngas quality rather than the CO2 atmosphere. The data acquired have been further applied to establish an artificial neural network (ANN)-based pyro-gasification prediction model. Although MSW composition varies significantly due to geographic differences, the model is robust enough to predict MSW pyro-gasification performance with different waste sources. To further enhance syngas properties and reduce gasification temperature as optimization of pyro-gasification process, MSW steam catalytic gasification is studied using calcium oxide (CaO) as an in-situ catalyst. The influence of CaO addition, steam flowrate and reaction temperature on H2-rich gas production is also investigated. The catalytic gasification using CaO allows a decrease of more than 100 oC in the reaction operating temperature in order to reach the same syngas properties, as compared with non-catalyst high-temperature gasification. Besides, the catalyst activity (de-activation and re-generation mechanisms) is also evaluated in order to facilitate an industrial application. 650 oC and 800 oC are proven to be the most suitable temperature for carbonation and calcination respectively, while steam hydration is shown to be an effective CaO re-generation method. Afterwards, a systematic and comprehensive life cycle assessment (LCA) study is conducted. Environmental benefits have been achieved by MSW gasification compared with conventional incineration technology. Besides, pyrolysis and gasification processes coupled with various energy utilization cycles are also modeled, with a gasification-gas turbine cycle system exhibits the highest energy conversion efficiency and lowest environmental burden. The results are applied to optimize the current waste-to-energy route, and to develop better pyro-gasification techniques
Björkvall, Gunilla. "Corpus troporum. 5 : Les deux tropaires d'Apt, mss. 17 et 18 : inventaire analytique des mss. et édition des textes uniques". Doctoral thesis, Stockholms universitet, Humanistiska fakulteten, 1986. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-84111.
Texto completoWinkelmann, Thomas. "Bewegungs- und Mischverhalten hochviskoser Flüssigkeiten im Mehrschneckenextruder MSE /". Aachen : Shaker, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009548736&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Texto completoLam, Shuk-pik y 林淑碧. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085647.
Texto completoBaptista, Christiane Meiler. "MSys: uma ferramenta de acompanhamento de atividades para sistemas de aprendizado eletrônico". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/3/3141/tde-09012008-123220/.
Texto completoE-learning content creation is not an easy task, but its evaluation is even more complex. In order to evaluate if the content is adequate to the students needs, it would be helpful to know how the student assimilated the learning content, how he reacted to it and the period of time spent on the learning object. Besides, considering the different cognitive features of learning and the possibility of adjustment of the didactic content, it could help teacher\'s evaluation in an available online course. This work describes a monitoring system (Msys) that tracks the level of utilization of student\'s activities, and presents summarized and comparative results to the teacher and the student. Even though the widespread use of several LMS (Learning Management System) environments today, the importance of tools capable of offering a detailed monitoring of student\'s activities has not been recognized. This work focus on how the tool was created using current standards on digital content construction, defining functional requirements to its development and presenting simulation results that is a proof-ofconcept. Also, it is presented a prototype of the tool, validating the interfaces of capture and results presentation, showing that is possible to integrate it to online learning systems, bringing benefits to the teacher evaluation.