Bibliografías temáticas / Mrj

Literatura académica sobre el tema "Mrj"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 26 de abril de 2022

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros

Elija tipo de fuente:

Índice

Consulte las listas temáticas de artículos, libros, tesis, actas de conferencias y otras fuentes académicas sobre el tema "Mrj".

Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.

También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.

Artículos de revistas sobre el tema "Mrj"

1

Dai, Yan-Shan, Jian Xu y Jeffery D. Molkentin. "The DnaJ-Related Factor Mrj Interacts with Nuclear Factor of Activated T Cells c3 and Mediates Transcriptional Repression through Class II Histone Deacetylase Recruitment". Molecular and Cellular Biology 25, n.º 22 (15 de noviembre de 2005): 9936–48. http://dx.doi.org/10.1128/mcb.25.22.9936-9948.2005.

Texto completo
Resumen
ABSTRACT The calcium-regulated protein phosphatase calcineurin (PP2B) functions as a regulator of gene expression in diverse tissues through the dephosphorylation and activation of a family of transcription factors known as nuclear factor of activated T cells (NFAT). Here we show that NFATc3, in addition to being calcium responsive, is regulated through an indirect recruitment of class II histone deacetylases (HDACs). Specifically, yeast two-hybrid screening with the rel homology domain of NFATc3 identified the chaperone mammalian relative of DnaJ (Mrj) as a specific interacting factor. Mrj and NFATc3 were shown to directly associate with one another in mammalian cells and in vitro. Mrj served as a potent inhibitor of NFAT transcriptional activity within the nucleus through a mechanism involving histone deacetylase recruitment in conjunction with heat shock stimulation. Indeed, Mrj was determined to interact with class II histone deacetylases, each of which translocated to the nucleus following heat shock stimulation. Mrj also decreased NFATc3 occupancy of the tumor necrosis factor-α promoter in cardiomyocytes in an HDAC-dependent manner, and Mrj blocked calcineurin-induced cardiomyocyte hypertrophic growth. Conversely, small-interfering-RNA-mediated reduction of Mrj augmented NFAT transcriptional activity and spontaneously induced cardiac myocyte growth. Collectively, our results define a novel response pathway whereby NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj.
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Salazar, Bianca Alves, Mônica Rodrigues Campos y Vera Lucia Luiza. "A Carteira de Serviços de Saúde do Município do Rio de Janeiro e as ações em saúde na Atenção Primária no Brasil". Ciência & Saúde Coletiva 22, n.º 3 (marzo de 2017): 783–96. http://dx.doi.org/10.1590/1413-81232017223.33442016.

Texto completo
Resumen
Resumo Objetivou-se identificar a oferta de ações e procedimentos pelas equipes de saúde da família (eSF), tendo por base a Carteira de Serviços (CS) do Município do Rio de Janeiro (MRJ) e os principais fatores associados a esta oferta, nos diferentes estratos populacionais. Foram utilizados dados do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica, aplicado a 17.202 eSF, de junho a setembro de 2012 no Brasil. Foram variáveis desfecho: eSF pertencer ao MRJ; eSF ofertar todos os nove procedimentos da CS-MRJ. Foram conduzidas análises uni, bi e multivariada. Evidenciou-se melhor desempenho do MRJ em relação aos demais grandes centros urbanos (EP6#) (p < 5%) em 10 das 14 ações de saúde analisadas. O prontuário eletrônico apresentou 96% de implantação nas eSF do MRJ, contrastando com 34% nas dos EP6# e 14% no Brasil. Tanto no MRJ quanto no EP6# encontrou-se baixa oferta de serviços de saúde mental (cerca de 56%). Enquanto a oferta de procedimentos de baixa complexidade foi um problema maior nos grandes centros, a oferta de ações em saúde nas diferentes linhas de cuidado foi um problema maior nos municípios pequenos. No geral, o MRJ mostrou melhor desempenho quando comparado à média de municípios de grande porte. A carteira de serviço pareceu ser um importante instrumento gerencial.
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

DEB, BISWAJIT, KALPESH KAPOOR y SUKANTA PATI. "ON mRJ REACHABILITY IN TREES". Discrete Mathematics, Algorithms and Applications 04, n.º 04 (diciembre de 2012): 1250055. http://dx.doi.org/10.1142/s1793830912500553.

Texto completo
Resumen
Given a tree T, a configuration of T is denoted by [Formula: see text] which represents that there is a robot at the vertex u, a hole at the vertex v and obstacles in the remaining vertices of T. By an mRJ move we mean that the robot is moved from the vertex u to a vertex v having a hole by jumping over m obstacles along a path. The case m = 0 is a simple move of taking the robot from u to the adjacent vertex v with a hole. We investigate the problem of moving a robot from its initial position to all the other vertices using mRJ moves (for some fixed m) in addition to simple moves. A tree is said to be mRJ reachable if there exists a configuration from which it is possible to take the robot to any vertex of the tree using simple or mRJ moves. A connected graph is 1RJ reachable. However, for m ≥ 2 there exists graphs that are not mRJ reachable. We characterize 2RJ and 3RJ reachable trees and give bound for the diameter of mRJ reachable trees.
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Oshima, K., T. Kojima, H. Watanabe, M. Fukushima, O. Dochi, N. Takenouchi, M. Komatsu y N. Yamamoto. "247GENE EXPRESSION OF MAMMALIAN RELATIVE OF DNAJ IN BOVINE ENDOMETRIUM DURING EARLY PREGNANCY". Reproduction, Fertility and Development 16, n.º 2 (2004): 244. http://dx.doi.org/10.1071/rdv16n1ab247.

Texto completo
Resumen
The mammalian relative of DNAJ (MRJ), a member of the molecular chaperones that are known as heat shock proteins, plays an important role in the process of murine chorioallantoic fusion. The objective of this study was to determine the expression pattern of MRJ in the bovine endometrium during early and mid-pregnancy using quantitative RT-PCR. Twenty-eight Japanese Black cows, aged between 1.2 and 15.2 years, with normal estrous cycles, were used in this study. Twenty-one cows were used for study of the level of MRJ during pregnancy. They were artificially inseminated, and their endometrial tissues were collected on Days 16 to 21 (n=7), 30 to 36 (n=6), 48 to 49 (n=4) and 74 to 140 (n=4) of pregnancy. Seven cows were used as controls for the study of cyclic level of MRJ, and their endometrial tissues were collected on Days 13 to 14 (n=4) and 17 to 20 (n=3) of the estrous cycle. The caruncles and the intercaruncles were isolated from the endometrial tissues. All tissues were frozen immediately using liquid nitrogen. Total RNA from these samples was extracted from the tissue using Trizol (Invitrogen Corp., Carlsbad, CA, USA). The first strand of cDNA was synthesized from the total RNA by oligo (dT)12–18 and SuperScript™ II RNase H- Reverse Transcriptase (Invitrogen Corp.) according to the manufacturer’s instructions. Primers and the TaqMan probe for MRJ and glyceraldehyde-phosphate-dehydrogenase (GAPDH) were designed using the primer design software Primer Express™ (Applied Biosystems, Foster City, CA, USA). Bovine GAPDH was used as an internal standard. All PCR reactions were performed using a TaqMan™ PCR Reagent Kit and a MicroAmp Optical 96-Well Reaction Plate and Cap (Applied Biosystems). The assay used an ABI Prism 7700 Sequence Detector (Applied Biosystems). Signals were detected according to the manufacturer’s instructions. The relative level of MRJ expression was calculated on the basis of GAPDH quantity (the method of calculation: relative level=MRJ quantity/GAPDH quantity). Data were analyzed by one-way ANOVA, and means were conpared by Tukey-Kramer’s HSD test. Mammalian relative of DNAJ genes were expressed in all samples examined;; the levels in intercaruncle tended to be greater than those in caruncle. Although MRJ expression level at Days 16 to 21 of pregnancy was greater than at other days during pregnancy, there were no significant differences between the levels at Days 16 to 21 of pregnancy and those of the estrous cycle. These results suggest that MRJ is produced in the endometrium and may play a role in early and mid-pregnancy and the estrous cycle.
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Zhou, Yuan Qi y Liang Yan. "A Jump Diffusion Model for Evaluating of an Oilfield Development Project and its Application". Advanced Materials Research 616-618 (diciembre de 2012): 1563–67. http://dx.doi.org/10.4028/www.scientific.net/amr.616-618.1563.

Texto completo
Resumen
Irreversible investments with largest outlay made with incomplete information are the mainstay of the oilfield development. Real Options Analysis (ROA) is a useful tool for making investment decisions under market uncertainty. Normal information generates continuous mean-reverting process for oil prices, whereas random abnormal information generates discrete jumps of random size. We will evaluate an oilfield development project using Mean-Reversion with Jumps (MRJ). As an example, we compare MRJ and Geometric Brownian Motion (GBM )valuation for the timing of investment and the optimization problem. This article concludes MRJ in some cases can induce better corporate decisions than GBM.
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Zhou, Yuan Qi y Liang Yan. "Comparing Two Models for Evaluating an Oilfield Development Project: Mean-Reversion with Jumps, Geometric Brownian Motion". Advanced Materials Research 616-618 (diciembre de 2012): 1568–72. http://dx.doi.org/10.4028/www.scientific.net/amr.616-618.1568.

Texto completo
Resumen
With incomplete information, the oilfield development is a high-risk venture and requires the largest outlay which is not Irreversible. Real Options Analysis (ROA) is a useful tool for making investment decisions under market uncertainty. We evaluate an oilfield development project using Mean-Reversion with Jumps (MRJ) and Geometric Brownian Motion (GBM). As an example, we compare GBM and MRJ valuation for the timing of investment and the optimization problem. Furthermore, we investigate the impact of different parameters of the two stochastic oil price models. This article concludes MRJ has a better risk management ability than GBM has, especially in a higher market oil price of risk.
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Mahmood, Abid, Tanvir Shahzad, Sabir Hussain, Qasim Ali, Hayssam M. Ali, Sanaullah Yasin, Muhammad Ibrahim, Mohamed Z. M. Salem y Muhammad Khalid. "Evaluation of Symbiotic Association between Various Rhizobia, Capable of Producing Plant-Growth-Promoting Biomolecules, and Mung Bean for Sustainable Production". Sustainability 13, n.º 24 (14 de diciembre de 2021): 13832. http://dx.doi.org/10.3390/su132413832.

Texto completo
Resumen
To feed the increased world population, sustainability in the production of crops is the need of the hour, and exploration of an effective symbiotic association of rhizobia with legumes may serve the purpose. A laboratory-scale experiment was conducted to evaluate the symbiotic effectiveness of twenty wild rhizobial isolates (MR1–MR20) on the growth, physiology, biochemical traits, and nodulation of mung bean to predict better crop production with higher yields. Rhizobial strain MR4 resulted in a 52% increase in shoot length and 49% increase in shoot fresh mass, while MR5 showed a 30% increase in root length, with 67% and 65% improvement in root fresh mass by MR4 and MR5, respectively, compared to uninoculated control. Total dry matter of mung bean was enhanced by 73% and 68% with strains MR4 and MR5 followed by MR1 and MR3 with 60% increase in comparison to control. Rhizobial strain MR5 produced a maximum (25 nodules) number of nodules followed by MR4, MR3, and MR1 which produced 24, 23, and 21 nodules per plant. Results related to physiological parameters showed the best performance of MR4 and MR5 compared to control among all treatments. MR4 strain helped the plants to produce the lowest values of total soluble protein (TSP) (38% less), flavonoids contents (44% less), and malondialdehyde (MDA) contents (52% less) among all treatments compared to uninoculated control plants. Total phenolics contents of mung bean plants also showed significantly variable results, with the highest value of 54.79 mg kg−1 in MR4 inoculated plants, followed by MR5 and MR1 inoculated plants, while the minimum concentration of total phenolics was recorded in uninoculated control plants of mung bean. Based on the results of growth promotion, nodulation ability, and physiological and biochemical characteristics recorded in an experimental trial conducted under gnotobiotic conditions, four rhizobial isolates (MR1, MR3, MR4, and MR5) were selected using cluster and principal component analysis. Selected strains were also tested for a variety of plant-growth-promoting molecules to develop a correlation with the results of plant-based parameters, and it was concluded that these wild rhizobial strains were effective in improving sustainable production of mung bean.
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Urban, Boris y Jabulile Galawe. "The mediating effect of self-efficacy on the relationship between moral judgement, empathy and social opportunity recognition in South Africa". International Journal of Entrepreneurial Behavior & Research 26, n.º 2 (13 de noviembre de 2019): 349–72. http://dx.doi.org/10.1108/ijebr-05-2019-0271.

Texto completo
Resumen
Purpose Scholars researching entrepreneurship argue that the distinct characteristics of social entrepreneurs, together with the particular category of opportunities they pursue, invite us to further understand social entrepreneurship (SE) as a distinct field of investigation. The purpose of this paper is to investigate opportunity recognition behaviour of social entrepreneurs and closely related unique attributes of empathy, moral judgement (MRJ) and self-efficacy, in an emerging market African context. Design/methodology/approach A survey was administered to social entrepreneurs across two of the largest provinces in South Africa, namely Cape Town and Gauteng. Hypotheses were statistically tested using correlational analysis and hierarchical regression with mediation effects. Findings Results reveal that social entrepreneurial self-efficacy (ESE) plays a significant mediating effect in the relationship between MRJ and social opportunity recognition. Moreover, perceived MRJ and social ESE act as important determinants of increased social opportunity recognition. Originality/value This study has brought to attention the relevance of opportunity recognition to social entrepreneurs, while recognising their distinctive features in terms of empathy and MRJ. While self-efficacy and opportunity recognition are relatively well established in the traditional entrepreneurship literature, this study extends the reach of these variables into the SE domain.
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Hunter, P. J., B. J. Swanson, M. A. Haendel, G. E. Lyons y J. C. Cross. "Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development". Development 126, n.º 6 (15 de marzo de 1999): 1247–58. http://dx.doi.org/10.1242/dev.126.6.1247.

Texto completo
Resumen
We have identified a novel gene in a gene trap screen that encodes a protein related to the DnaJ co-chaperone in E. coli. The gene, named Mrj (mammalian relative of DnaJ) was expressed throughout development in both the embryo and placenta. Within the placenta, expression was particularly high in trophoblast giant cells but moderate levels were also observed in trophoblast cells of the chorion at embryonic day 8.5, and later in the labyrinth which arises from the attachment of the chorion to the allantois (a process called chorioallantoic fusion). Insertion of the ROSAbetageo gene trap vector into the Mrj gene created a null allele. Homozygous Mrj mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, which precluded formation of the mature placenta. At embryonic day 8.5, the chorion in mutants was morphologically normal and expressed the cell adhesion molecule beta4 integrin that is known to be required for chorioallantoic fusion. However, expression of the chorionic trophoblast-specific transcription factor genes Err2 and Gcm1 was significantly reduced. The mutants showed no abnormal phenotypes in other trophoblast cell types or in the embryo proper. This study indicates a previously unsuspected role for chaperone proteins in placental development and represents the first genetic analysis of DnaJ-related protein function in higher eukaryotes. Based on a survey of EST databases representing different mouse tissues and embryonic stages, there are 40 or more DnaJ-related genes in mammals. In addition to Mrj, at least two of these genes are also expressed in the developing mouse placenta. The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities.
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Miyamura, Koichi, Masahide Osaki, Tatsunori Goto, Takanobu Morishita y Yukiyasu Ozawa. "Optimal Interval for Detection of Molecular Relapse after Stop of Tyrosine Kinase Inhibitor (TKI) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) Caliculated By Kinetics of BCR-ABL Transcripts". Blood 136, Supplement 1 (5 de noviembre de 2020): 21. http://dx.doi.org/10.1182/blood-2020-141480.

Texto completo
Resumen
Background In Ph+ALL patients, prophylactic/maintenance administrations of TKI are used after the protocol treatment. Unlike Chronic myelogenous leukemia (CML), after TKI stopped, there is no consensus about how often to monitor to detect molecular relapse. In the current study, from clinical data of 31 patients we tried to determine the optimal frequency of MRD monitor for better prognosis using a mathematical model. Methods Doubling time (DT) and Growth rate (GR) were retrospectively calculated by the increase of BCR-ABL from 99 kinetic data from 31 patients with Ph+ALL at molecular relapse. Measurement of amount BCR-ABL was performed by RQ-PCR. Mimicking CML, we defined BCR-ABL/ABL ratio of 0.1% as "MR3 (Major molecular response)" and undetectable levels of BCR-ABL transcript as "MR5 (Complete molecular response)". In order to investigate the relationship between tumor burden (BCR/ABL) at the time of MRD detection and prognosis, it was divided into 3 groups, BCR/ABL&lt;0.1% (MR3), 0.1%&lt;BCR/ABL&lt;1% (MR2) and BCR/ABL&gt;1% (MR1). This study was approved by the institutional review committee. Results The doubling time was 1.3 days (GR 0.7%/day) to 95.4 days (70.8%/day) with a median of 12.3 days (5.8%). The rate of increase was compared by three groups of tumor burden. The DT among patients in MR1 was shorter than those in MR3 and MR2 (7.7 days vs 15.2 days in median, t-test p&lt;0.01). There were no differences of DT in sex, age, treatments and BCR/ABL mutation. Most patient had multiple kinetic data and the smallest amount of BCR/ABL was used in each patient. Among 8 patients who showed MR3 (MR3pt) and 11 who showed MR2 (MR2pt), 14 are alive at this analysis, while among 10 patients who showed MR1 (MR1pt), only 1 patient is alive.(Log-rank test, p&lt;0.1) (Figure) Median survival time is 882 days, 330 days and 16 days in MR3pt, Mr2pt and MR1pt, respectively. All patients died of progression of the disease. Finding molecular relapse before MR2 may related to better results. Optimal interval of MRD detection We set several hypotheses to determine the optimal frequency to detect early recurrence of leukemia. We estimated that patients with MR2 and MR5 have 1010 and 107 Ph+ cells in body, respectively. We defined "MR2" and "MR5" as "optimal intervention threshold" and "detection threshold". From our clinical data, we tentatively determined that doubling time of leukemia growth is distributed between 1 day (GR 100%/day) and 100days (0.7%). Also, we assumed that single cell has a relapse potency and the GR is constant during observation in each patient. The number of Ph+ cells in a MR5 patient who would potentially relapse might be distributed between 1 cell and 1 x 107 (MR5). "Success" was defined as if molecular relapse is detected between M5 and MR2 and "Failure" was defined as if detected more than MR2. According to the daily clinical practice, the optimal examination interval is tentatively every 7 days, every 14 days, every 28 days, every 56 days, every 84 days, every 6 months, and every year. First, in order to calculate the growth rate that would be successful at 7-day intervals, the rate of 168%/day for 1 cell to increase 107 (MR5) in 7 days was calculated. This rate is faster than the maximum rate of 100%/day in this study, so an interval of 7 days is good for the initial period. Similarly, at 14-day intervals, 68%/day is calculated, and in this case, it requires 32 days to increase 107 (MR5) from 1 cell. As a result, after 32.7 days, 14-day intervals are acceptable. Similarly, the calculated results for 28 days, 56 days, 84 days, 6 months, and 1 year are shown in the Table. MRD can be found before M3 (success) with 28-day intervals after 65 days, 56-day intervals after 131 days, 84-day intervals after 196 days, 6-month intervals after 419 days and 1-year intervals after 852 days. Conclusion Taken together, soon after stop of TKI, more frequent monitoring of MRD than in "treatment free remission" in CML is needed. The interval can be prolonged with the passage of time. In several patients, hematopoietic stem cell transplantation (HSCT) was possible due to early intervention by changing TKI and chemotherapy. After HSCT, TKI combined with rapid reduction of immune-suppressants and donor lymphocyte infusion successfully related with long term survival. (data will be shown in ASH) Thus, the tight monitoring according to the mathematical model is important. The current strategy may be applied to other leukemia in which MRD monitoring by PCR is established. Disclosures Miyamura: Bristol-Myers Squibb Co., Ltd.:Honoraria;Celgene Co., Ltd.:Honoraria;Daiichi-Sankyo Co., Ltd.:Honoraria;Otsuka Co., Ltd.:Honoraria;Pfizer Co., Ltd.:Honoraria;Novartis Co., Ltd.:Honoraria.Goto:Takeda Pharmaceutical Co., Ltd:Honoraria;Novartis Pharma Co., Ltd.:Honoraria.Morishita:Bristol-Myers Squibb Co., Ltd.:Honoraria.Ozawa:Novartis Co., Ltd.:Honoraria.
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Tesis sobre el tema "Mrj"

1

Hunter, Patricia Jean. "A Dnaj-related co-chaperone, Mrj, is required for placental devlopment in mice". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0001/MQ40792.pdf.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

de, Bock Charles Edo St George Clinical School UNSW. "Novel protein interactors of urokinase-type plasminogen activator receptor". Awarded by:University of New South Wales. St George Clinical School, 2005. http://handle.unsw.edu.au/1959.4/23009.

Texto completo
Resumen
The plasminogen activator (PA) system plays an important role in cell adhesion, migration and invasion, and may require the coordinated expression of various proteins. The human urokinase-type plasminogen activator (uPA) receptor (uPAR) is a central protein component of the PA system. By binding its ligand uPA, uPAR can direct proteolysis of the extracellular matrix. Also, it is now apparent that uPAR can initiate proteolytic independent signal transduction to influence angiogenesis, inflammation, wound repair and tumour progression. To determine whether any novel proteins interacted with uPAR, a yeast two-hybrid screening analysis was undertaken using alternate uPAR domain constructs as baits. These included full-length three domain uPAR (uPAR-DIDIIDIII), two domain uPAR (uPAR-DIIDIII), and each individual uPAR domain (uPAR-DI, uPAR-DII and uPAR-DIII). A number of proteins were identified as putative candidate interactors for the alternate constructs, with two of special interest for uPAR-DIDIIDIII. These were the heat shock protein Mrj, and the extracellular matrix protein fibulin-2. The protein Mrj was shown to bind uPAR both in vitro and in vivo using GST-pull down and co-immunoprecipitation assays respectively. The GST-pull down assay identified the interaction between Mrj and uPAR dependent on the C-terminal domain of Mrj and DI of uPAR. Using in vivo co-immunoprecipitation analysis, Mrj also bound to uPAR. Preliminary data suggest the association between uPAR and Mrj may play a role in the regulation of apoptosis. In regard to the uPAR interactor of fibulin-2, a calcium dependent binding interaction with uPAR was identified using the GST-pull down assay. However due to the large molecular weight and stringent conditions needed to solubilise fibulin-2, it was not possible to co-immunoprecipitate both uPAR and fibulin-2. Together, the identification of both Mrj and fibulin-2 amongst other candidate interactors of uPAR presented here provides further insight into the intricate relationship between uPAR and other proteins which may influence a range of biological functions.
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Lin, Zhen St George Clinical School UNSW. "Molecular mechanism of cancer related to urokinase receptor: DNAzyme-mediated inhibition and Novel protein interactors of urokinase receptor". Awarded by:University of New South Wales. St George Clinical School, 2007. http://handle.unsw.edu.au/1959.4/31893.

Texto completo
Resumen
The urokinase receptor (uPAR) plays a central role in metastatic process. It???s evident uPAR is overexpressed across a variety of tumour cells and leads to the increased aggressiveness and poor prognosis of cancer. Inhibition of uPAR expression can block metastatic potential in many tumours. In addition, besides uPA, there are several other proteins which have been confirmed to interact with uPAR, such as vitronectin and integrins. These interactions also contribute to signal transduction and the functions of uPAR complex. Therefore, downregulation of uPAR expression by targeting uPAR mRNA or protein, or by regulating the uPAR partners would be potential therapeutic strategies for prevention of cancer metastasis. There are two main aspects contained in this thesis. Firstly, three specific DNAzymes targeting uPAR mRNA were designed to downregulate uPAR expression in vitro and their effects to decrease cancer cell invasion studied in a human osteosarcoma cell line Saos-2. The results showed that two of them (Dz483 and Dz720) cleaved uPAR transcript in vitro with high efficacy and specificity and the Dz720 inhibited uPAR protein levels by 55% in Saos-2 cells. Besides, the Dz720 significantly suppressed Saos-2 cell invasion using an in vitro matrigel assay. Secondly, two potential uPAR partners from yeast two-hybrid screening, a heat shock protein MRJ and an anti-apoptosis protein HAX-1, were characterised and their functions binding with uPAR investigated. The interactions were confirmed by co-immunoprecipitation, GST-pull down assay and confocal microscopy in cancer cells. In addition, there was a 50% increase in cell adhesion after transfection with MRJ. This increase in adhesion is dependent on the uPAR/full length MRJ interaction as cells transfected with the mutant construct containing only N-terminal region or C-terminal region of MRJ had no increase in cell adhesion. The observed increase in adhesion to vitronectin by MRJ was also blocked by an anti-uPAR domain I antibody suggesting that the induced adhesion is at least in part contributed by uPAR on the cell surface. Together, the identification of both MRJ and HAX-1 as uPAR interactors provides further insight into the intricate relationship between uPAR and other proteins which may develop potential approaches for cancer therapy.
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Slovak, Peter Michael. "Characterisation of the mre and mrd loci of Rhodobacter sphaeroides". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414270.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Inturi, Satya Prakash Reddy y Chaitanya Macherla. "System Performance of MIMO MRT/MRC System under Perfect CSI". Thesis, Blekinge Tekniska Högskola, Institutionen för datavetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-21137.

Texto completo
Resumen
Multiple Input and Multiple Output (MIMO) is one of the techniques used tiimprove the system performance. In this thesis, we improve and evaluate the system performance of MIMO deploying MRT technique at the transmitter and MRCtechnique at the receiver with an assuming that the system can obtain perfect CSI.We derived expressions for outage probability and symbol error rate and simulationgraphs for SISO, SIMO, MISO, and MIMO in terms of outage probability. Our results show that the MIMO system performance is better than other configurations.We also observed that SISO have the least performance where SIMO and MISOhave same performance. The performance also increases as the number of antennasincrease in the system and it is suggested to use MIMO when performance is givehigh priority than cost.
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Chalmers, Kirsten Hardie. "Fluorinated paramagnetic probes for 19-F and 1-H MRS/MRI". Thesis, Durham University, 2011. http://etheses.dur.ac.uk/879/.

Texto completo
Resumen
Novel CF3-labelled lanthanide(III) complexes have been synthesised for use as probes for 19-F and 1-H magnetic resonance spectroscopy and imaging. The syntheses and evaluation of two classes of fluorinated paramagnetic complexes are defined. Notably, the 19-F magnetic resonance relaxation processes for the complexes have been assessed, allowing for the analysis of the interplay between applied field, Ln(III) ion and rotational correlation time on relaxation properties. Strategies employed to enhance signal intensity are discussed, examining a number of different of fluorinated mono- and di-amide cyclen ligands. Systems incorporating phosphinate pendant arms are of particular interest, resulting in complexes with favourable isomer distributions, faster longitudinal relaxation rates and narrower linewidths. Finally, the synthesis of high molecular weight conjugates with paramagnetic fluorinated complexes is described. Three different classes of medium to high molecular adducts were considered, with the merits and limitations of each assessed. The desirable formation of one species in solution, ease of solubility and attractive 19F and 1H relaxometric properties render the chitosan conjugates promising candidates for future use as imaging probes.
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Ramamurthy, Senthil. "Localized double-quantum filtered correlated spectroscopy on 3T MRI/MRS scanner". Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=4012.

Texto completo
Resumen
Thesis (M.S.)--West Virginia University, 2005.
Title from document title page. Document formatted into pages; contains ix, 69 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 65-69).
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Chao, Hui Ph D. Massachusetts Institute of Technology. "Multi-echo methods for fast MRI and MRS of ³¹P containing compounds". Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43335.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Chen, Hua Hsuan. "The application of MRI and MRS in psychiatry and performance evaluation of magnetic field homogeneity in MRI : a dissertation /". San Antonio : UTHSC, 2006. http://proquest.umi.com/pqdweb?did=1155567931&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Hejtmánek, Ondřej. "Projekt datového centra - strukturovaná kabeláž". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219768.

Texto completo
Resumen
This master’s thesis is concerned with analysis of cabling and cabling systems in data center and with their projection as follows. The part of the work is aimed at the measurement parameters of metal cables which are used in data center with noise. The first part is focused on analyzing the structure of the data center and cabling used in it. The structure of the data center is based on the TIA-942 and consists of an entrance room, main distribution area MDA, horizontal distribution area HDA , zone distribution area ZDA and the equipment distribution area EDA. Divided into backbone cabling and horizontal cabling and use standard and pre-terminated cabling. The measurement results of structured metal cabling with noise are discussed in the next part. There were used these types of cables UTP, FTP and S/FTP. The measurement was performed in the electricity substation and in the laboratory of electromagnetic compatibility. The third part of this work deals with the actual design of structured cabling for the data center. In the first design we use the standard installation, the second preterminated cabling. For both types of installation cost statement is processed (CAPEX). Thesis is also completed with DC design drawings and rack drawings.
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Libros sobre el tema "Mrj"

1

Hunter, Patricia Jean. A Dnaj-related co-chaperone, Mrj, is required for placental development in mice. Ottawa: National Library of Canada, 1998.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Nangyāl, Isḥāq. Sīndūnah ham mrī: Sinduna ham mri. Kabul]: Yawn Kulturī Yawn, 2008.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Siṅkha, Maṅʻʺ. Mre lyhokʻ vijjā Rvhe Mra Sā: Mahāgandhārī vatthu krīʺ. Camʻʺ khyoṅʻʺ, [Rangoon]: Manomaya Cā pe, 1997.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

vanʻʺ, Cuinʻ. Pi tokʻ mre ka ma he sī naiʹ rhve a mru te. Ranʻ kunʻ mruiʹ: Raññʻ mvanʻ Ūʺ Cā pe, 2004.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Mollie's memories: The life story of Mrs. M.J. Holmes, OBE, JP, Ballymoney. Ballycastle [Northern Ireland]: Impact Publishers, 2006.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Mraṅʻʹ, Taṅʻ. Sa ra phī kruiṅʻ lhuiṅʻ saṅʻʺ pā taiʹ vaṅʻʺ mra raññʻ mre. [Rangoon]: Ūʺ ʼUnʻʺ Moṅʻ, 2001.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Bjelica, Isidora. Moj život, moj skandal. Beograd: Izdavačka kuča "Draganić", 2005.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Paunović, Oliver. Moj city, moj Niš. Niš: City Marketing Centar [sic], 2008.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Dimeski, Vasile. Tatko moj tatko moj. Skopje: Dijalog, 2011.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Paunović, Oliver. Moj city, moj Niš. Niš: City Marketing Centar [sic], 2008.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Capítulos de libros sobre el tema "Mrj"

1

Zhu, Meicai, Chenggang Liu, Ying Liu, Yinjing Wang, Tao Chen, Xinhua Zhao y Yaning Liu Liu. "Bioluminescence Assay for the Human Chaperone MRJ Facilitated Refolding of Luciferase in Vitro". En Biophotonics, 99–107. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-24996-6_8.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Kim, Denise S., Remy R. Lobo y Alon Kahana. "Orbital MRA/MRV". En Atlas of Orbital Imaging, 1–4. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-41927-1_87-1.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Kim, Denise S., Remy R. Lobo y Alon Kahana. "Orbital MRA/MRV". En Atlas of Orbital Imaging, 117–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62426-2_87.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Chang, David S., Foster D. Lasley, Indra J. Das, Marc S. Mendonca y Joseph R. Dynlacht. "MRI-Linear Accelerator (MRL)". En Basic Radiotherapy Physics and Biology, 175–84. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-61899-5_17.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Kaiser, Werner A. "Introduction". En MR Mammography (MRM), 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77256-6_1.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Kaiser, Werner A. "Basic Concepts". En MR Mammography (MRM), 3–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77256-6_2.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Kaiser, Werner A. "Brief Review of the Development of Magnetic Resonance Mammography". En MR Mammography (MRM), 23–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77256-6_3.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Kaiser, Werner A. "Present Indications for MRM". En MR Mammography (MRM), 27. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77256-6_4.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Kaiser, Werner A. "Optimum Procedure for the MRM Examination". En MR Mammography (MRM), 29–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77256-6_5.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Kaiser, Werner A. "Clinical Aspects". En MR Mammography (MRM), 37–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77256-6_6.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.

Actas de conferencias sobre el tema "Mrj"

1

Robin, Michael, Thomas Brogan y Eric Cardiff. "An Ammonia Microresistojet (MRJ) for Micro satellites". En 44th AIAA/ASME/SAE/ASEE Joint Propulsion Conference & Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2008. http://dx.doi.org/10.2514/6.2008-5288.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Ribeiro, Maria Clara da Cunha, Marina Andrade Chavarri Gomes, Júlia Freire Carvalho, Maria de Nazareth Smith Pereira da Silva y Luciana Freire de Carvalho. "Um olhar sobre a saúde materna no município do Rio de Janeiro: perspectivas de raça/cor". En 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311215.

Texto completo
Resumen
Introdução: O Sistema Único de Saúde (SUS) deve estar orientado e capacitado para a atenção integral à saúde da mulher, contemplando promoção da saúde, necessidades de saúde, controle de doenças e agravos e garantia do direito à saúde. As análises de situação de saúde são úteis para identificar desigualdades e tendências que subsidiem o planejamento, a gestão e a avaliação de políticas públicas. Objetivo: Descrever indicadores de saúde materna no município do Rio de Janeiro (MRJ) entre 1998 e 2018, sob a perspectiva de raça/cor. Método: Estudo descritivo sobre o perfil da saúde materna de residentes no MRJ entre 1998 e 2018. Com dados do Sistema de Informação sobre Nascidos Vivos, Sistema de Informação sobre Mortalidade e Sistema de Informação de Agravos de Notificação, analisaram-se a razão de mortalidade materna (RMM), a taxa de incidência de sífilis em gestantes, a cobertura de consultas de pré-natal e a proporção de partos cesáreos. Para a estratificação foi utilizada a variável raça/ cor, agregando as categorias pretos e pardos a fim de formar a categoria negros. A construção dos indicadores foi realizada com auxílio do software Excel, empregando dados disponíveis no TabNet Municipal - RJ, de acesso público e gratuito. Resultados: A RMM mede o risco de uma mulher morrer por causa relacionada ao ciclo gravídico-puerperal. No MRJ, a RMM apresenta uma tendência de aumento, que pode ser explicada pela melhor investigação dos óbitos de mulheres em idade fértil. No entanto, observa-se que a população negra apresenta, em média, RMM duas vezes maior que a população branca, o que evidencia o impacto das desigualdades sociais na assistência às mulheres. Em relação ao pré-natal, nota-se um avanço na cobertura ao longo do tempo. Em 1998, apenas 52% das gestantes haviam feito sete ou mais consultas; em 2008, verifica- se aumento para 66% e, em 2018, essa cobertura atingiu 81% das gestantes do MRJ. Porém, em 2018, enquanto 88% das gestantes brancas tiveram acesso a sete ou mais consultas, esse resultado é de 78% para as gestantes negras. A proporção de partos cesáreos no MRJ orbita em torno de 50% durante o período, com discreto aumento ao longo do tempo. A frequência de partos cesáreos é, em média, 50% maior na população branca do que na negra. Em relação à morbidade, há importante aumento na detecção de sífilis na gestação ao longo dos anos, de sete casos a cada 100 mil nascidos vivos em 2009 para 51 casos a cada 100 mil nascidos vivos em 2018. Ao se compararem gestantes brancas com negras, nota-se um risco duas vezes maior de as mulheres negras contraírem sífilis durante a gestação. Conclusão: Na análise de indicadores de saúde materna sob a perspectiva de raça/ cor, observa-se a influência de condições socioeconômicas nos desfechos obstétricos. Isso pode evidenciar desigualdades sociais, bem como dificuldades do sistema de saúde em oferecer acesso a todas as mulheres. Este trabalho pode fomentar discussões sobre o tema e fornecer subsídios para a proposição de políticas públicas locais.
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Menezes, Mitchell E., Aparna Mitra, Lalita A. Shevde y Rajeev S. Samant. "Abstract 997: Stability of β-catenin decides the tumor suppressive effect of MRJ". En Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-997.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Samant, Rajeev S., Aparna Mitra, Mitchell E. Menezes y Lalita A. Shevde. "Abstract 2289: MRJ(L) reverts mesenchymal phenotype and restricts malignancy by inhibiting Wnt/β-catenin signaling". En Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2289.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Benson, Michael, Daniel Chung, Gabriel Fuhrman, David Helmer, Ty Homan, Lynne Mooradian, Joshua Rhee, Christopher Elkins y Andrew Banko. "Three-Dimensional Concentration and Velocity Measurements of a Pulsatile Contaminant Release in a Model of Oklahoma City". En ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-23648.

Texto completo
Resumen
Abstract Motivated by the Joint Urban 2003 field project and subsequent studies, magnetic resonance imaging (MRI) techniques were used to collect full-field measurements of three-dimensional fluid velocity and concentration across a scaled model of 2003 Oklahoma City. The study was intended to develop, test, and demonstrate a repeatable puff release with MRI compatible equipment. In order to accomplish this, a contaminant was injected through the floor of a city model in discrete puffs using a solenoid valve. Sealed to fit inside a water channel, the 1:2,206 scale city model covered the central business district of the city as it was in 2003. The main flow was fully turbulent with a Reynolds number of 36,000, while vertical puff injection occurred at a Reynolds number of 2,642. Using MRV and MRC methods, the three components of velocity and concentration were measured at more than 2 million locations for each of the 12 phases of the injection period. MRV measurements examined the fluid flow with respect to building geometry. Collected at heights corresponding to this MRV data, MRC measurements enabled the analysis of the vertical and lateral dispersion of the contaminant. Ultimately, the study demonstrated a novel MRI technique through contaminant puff release and can be used for the validation of urban contaminant dispersion models.
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Benson, Michael J., Bret P. Van Poppel, Christopher J. Elkins y Mark Owkes. "Three Dimensional Velocity and Temperature Field Measurements of Internal and External Turbine Blade Features Using Magnetic Resonance Thermometry". En ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-76874.

Texto completo
Resumen
Magnetic Resonance Thermometry (MRT) is a maturing diagnostic used to measure three-dimensional temperature fields. It has great potential for investigating fluid flows within complex geometries leveraging medical grade MRI equipment and software along with novel measurement techniques. The efficacy of the method in engineering applications increases when coupled with other well established MRI-based techniques such as Magnetic Resonance Velocimetry (MRV). In this study, a challenging geometry is presented with direct application to a complex gas turbine blade cooling scheme. Turbulent external flow with a Reynolds number of 136,000 passes a hollowed NACA-0012 airfoil with internal cooling features. Inserts within the airfoil, fed by a second flow line with an average temperature difference of 30 K from the main flow and a temperature-dependent Reynolds number in excess of 1,800, produce a conjugate heat transfer scenario including impingement cooling on the inside surface of the airfoil. The airfoil cooling scheme also includes zonal recirculation, surface film cooling, and trailing edge ejection features. The entire airfoil surface is constructed of a stereolithography resin — Accura 60 — with low thermal conductivity. The three-dimensional internal and external velocity field is measured using MRV. The fluid temperature field is measured within and outside of the airfoil with MRT and the results are compared with a computational fluid dynamics (CFD) solution to assess the current state of the art for combined MRV/MRT techniques for investigating these complex internal and external flows. The accompanying CFD analysis provides a prediction of the velocity and temperature fields, allowing for errors in the MRT technique to be estimated.
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Yashaa, Ammar S. y Souran Manoochehri. "Fabrication and Characterization of Micro-Patterned Magnetorheological Elastomeric Structures". En ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-64535.

Texto completo
Resumen
This paper presents fabrication and characterization of micro-patterned magnetorheological elastomeric structures composed of magnetorheological fluid (MRF) sandwiched with magnetorheological elastomeric (MRE) materials. The MRE structures are made of polydimethylsiloxane (PMDS) with and without an additive of carbonyl iron (CI) particles with a size range of 6–9 um and the MRF is composed of silicon fluid mixed with the CI particles of the same size range. Three different SU-8 master molds of plain, longitudinal, and latitudinal patterns are constructed. Also, four MR elastomeric structures of different CI particle arrangements of isotropic MRE, anisotropic top-to-bottom-aligned MRE, anisotropic side-to-side-aligned MRE, and pure PDMS for each SU-8 master mold are fabricated. MRE structures are then characterized by using a tensile testing machine under a normal condition (off-state) and a low magnetic field condition (on-state). The tensile tests were performed to experimentally investigate their tunable properties. Later, the data gathered are compared for different conditions.
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Clayton, Erik H. y Philip V. Bayly. "Brain Response to Extracranial Acoustic Loads: Shear Wave Propagation Characterized by Vector Fields". En ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-63245.

Texto completo
Resumen
Traumatic brain injuries (TBI) due to blast are common in modern combat situations, and often lead to permanent cognitive impairment. Despite the prevalence and severity of blast-induced TBI, the condition remains poorly understood. Computer simulations of blast and blast injury mechanics offer enormous potential; however, computer models require accurate descriptions of tissue mechanics and boundary conditions in vivo. To gain insight into the mechanisms of blast injury, we applied direct (light) oscillatory pressure loading to the skulls of human volunteers, and measured displacement and strain fields using the methodology of magnetic resonance elastography (MRE). MRE is a non-invasive imaging modality that provides quantitative spatial maps of tissue stiffness. MRE is performed by inducing micron-amplitude propagating shear waves into tissue and imaging the resulting harmonic motion with standard clinical MRI hardware. Shear waves are initiated by an MR-compatible actuator and detected by a specialized “motion-sensitive” MRI pulse sequence (software). Motion sensitized MR images provide displacement field data which can be inverted to estimate material stiffness by invoking a restricted form of Navier’s equation. Clinical interest in MRE has largely been driven by the empirical relationship between tissue stiffness and health. However, the “raw” MRE data (3-D displacement measurements) themselves can elucidate loading paths, anatomic boundaries and the dynamic response of the intact human head. In this study, we use the MRE imaging technique to measure in vivo displacement fields of brain motion as the cranium is exposed to acoustic frequency pressure excitation (45, 60, 80 Hz) and we calculate the resulting shear-strain fields (2-D). We estimate the Poynting vector (energy flux) field to illuminate the directions of internal wave propagation, and to identify the energy absorbing and reflecting regions within the brain.
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Gu, Xiaoyu y Yancheng Li. "Comprehensive Investigations on Magnetic Field Distribution in a Solenoid". En ASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/smasis2013-3038.

Texto completo
Resumen
Finding engineering applications for a new class of smart material, magnetorheological elastomer (MRE), has been a major task for researchers in this field. Novel MRE devices, such as vibration absorbers and vibration isolators, have been proposed and fabricated to pioneer its engineering applications. In civil engineering, the author has proposed a novel MRE based isolator to be used in the base isolation system for mitigating the devastating effects of earthquakes on civil structures. For any MRE-based device, electromagnetic coil is evitable involved to provide magnetic field for the MRE materials. Comparing with magnetic circuit design in magnetorheological fluid (MRF) device, i.e. MR damper, MRE devices normally need a larger coil to energize the MRE materials, particularly for a large-scale MRE device. Therefore, investigation of the solenoid on the magnetic field distribution is of great importance for the design and development of MRE based device. In particular, provision of sufficient and uniform magnetic field is essential towards the success in designing MRF/MRE devices. To understand the mechanism of magnetic field generation in a solenoid is the key for device design and optimization. The main objective of this paper is to analytically investigate and experimentally validate the magnetic field distribution in a solenoid. The theoretical investigation starts from the analysis on an ideally thin cylindrical solenoid in order to obtain analytical results. To stimulate the coil which can be used in the design of MRE device, theoretical investigation is to conduct on a thick-wall cylindrical solenoid. Finite element analysis is also used to examine the magnetic field distribution in the solenoid. In order to verify the theoretical findings, experimental testing is conducted to acquire the magnetic field distribution in a sample solenoid. Results from analytical solution, finite element analysis and experimental testing agree very well. The findings provide valuable information for the design and optimization of the MRE device in which a solenoid is inevitably involved.
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Xu, Jing, Xiaofei Hu, Haiying Tang, Richard Kennan y Karim Azer. "Water-Fat Decomposition by IDEAL-MRI With Phase Estimation: A Method to Determine Chemical Contents In Vivo". En ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19296.

Texto completo
Resumen
High-resolution Magnetic Resonance Imaging (MRI) of humans and animals in vivo is routine and non-invasive. Identifying and quantifying chemical composition of tissue from acquired images is a challenge. MR spectroscopy (MRS) may be used to identify chemical components accurately over a finite volume in the tissue. However, the temporal and spatial resolutions are limited. Multi-spectral MRI exploits the multiple modes of MR such as T1, T2 and proton density maps and classifies voxels into different tissue types, but the chemical identity of the tissue remains unknown. Many fat suppression methods were developed because the unwanted fat signal often compromises image interpretability in clinical MRI, but these techniques are sensitive to MR field inhomogeneity. Multi-point Dixon methods separate MR images into water and fat images and are less sensitive to field inhomogeneity [1] and IDEAL-MRI (iterative decomposition of water and fat with echo asymmetry and least-squares estimation) improved upon the Dixon methods by avoiding the problem of phase unwrapping [2]. However, special care has to be taken when estimating the field map to avoid erroneous solutions to the least-squares estimation problem which lead to artifacts such as swapping of water and fat. The use of region growing schemes (with a reliable seed) mitigates this problem as demonstrated in previous studies [3][4]. However, the seed is not always reliable and growing schemes can be sensitive to phase discontinuities. Moreover, although the technology was successfully demonstrated on many clinical scanners, only limited applications were found in preclinical scanners with high MR field where the field inhomogeneity can be far worse [5]. We developed a robust and accurate algorithm to compute water and fat content on an 11.7T small animal scanner by improving upon existing phase estimation methods through multiple starting pixels and consensus-based region growing. The method, after further validation, has the potential of providing a translatable assay to study disease progression and regression related to fat and water contents in various animal models, such as studying atherosclerotic plaque composition.
Los estilos APA, Harvard, Vancouver, ISO, etc.

Informes sobre el tema "Mrj"

1

Hena, Ismat, Ubaidur Rob, Nargis Sultana, Md Hossain, Reena Yasmin, Tapash Das y Farid Ahmed. Introducing medical MR in Bangladesh: MRM final report. Population Council, 2013. http://dx.doi.org/10.31899/rh4.1061.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Espy, Michelle A. Portable MRI. Office of Scientific and Technical Information (OSTI), junio de 2012. http://dx.doi.org/10.2172/1045388.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Esserman, Laura J., Shelley Hwang y Nola Hylton. A New Perspective on DCIS Using MRI: Correlation of Tumor and Vessel Proliferation with MR Signal Enhancement. Fort Belvoir, VA: Defense Technical Information Center, octubre de 2001. http://dx.doi.org/10.21236/ada406087.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Esserman, Laura J. y Nola Hylton. A New Perspective on DCIS Using MRI: Correlation of Tumor and Vessel Proliferation with MR Signal Enhancement. Fort Belvoir, VA: Defense Technical Information Center, octubre de 2002. http://dx.doi.org/10.21236/ada412770.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Esserman, Laura J. A New Perspective on DCIS Using MRI: Correlation of Tumor and Vessel Proliferation with MR Signal Enhancement. Fort Belvoir, VA: Defense Technical Information Center, abril de 2004. http://dx.doi.org/10.21236/ada425879.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Phillips, Peter C. Early Detection of NF1 Brain Tumor Growth and Treatment Response by MRI, MRS and PET in a Trial of Novel Antitumor Drugs. Fort Belvoir, VA: Defense Technical Information Center, octubre de 1997. http://dx.doi.org/10.21236/ada376214.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Russell, Stuart. Complete Guide to MRS,. Fort Belvoir, VA: Defense Technical Information Center, junio de 1985. http://dx.doi.org/10.21236/ada328568.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Fritts, J. E. y J. P. McCord. Summary of field operations Magazine Road North Wells MRN-1 and MRN-2. Office of Scientific and Technical Information (OSTI), marzo de 1996. http://dx.doi.org/10.2172/231427.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Pavel Polozov et al. Fiber positioning and MRS response. Office of Scientific and Technical Information (OSTI), mayo de 2004. http://dx.doi.org/10.2172/823951.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Litman, Neal. Multiple-Unit MRE Leak Detector. Fort Belvoir, VA: Defense Technical Information Center, julio de 2000. http://dx.doi.org/10.21236/ada423409.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
También puede estar interesado en las bibliografías ampliadas sobre el tema "Mrj" para tipos de fuentes particulares:
Artículos de revistas Tesis Libros
Ofrecemos descuentos en todos los planes premium para autores cuyas obras están incluidas en selecciones literarias temáticas. ¡Contáctenos para obtener un código promocional único!

Pasar a la bibliografía