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Artículos de revistas sobre el tema "Molecular imaging applications"

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Autor: Grafiati

Publicado: 11 de marzo de 2023

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1

Ozeki, Yasuyuki. "Molecular vibrational imaging by stimulated Raman scattering microscopy: principles and applications [Invited]". Chinese Optics Letters 18, n.º 12 (2020): 121702. http://dx.doi.org/10.3788/col202018.121702.

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2

Tian, M. "Molecular Imaging: Fundamentals and Applications". Journal of Nuclear Medicine 56, n.º 2 (8 de enero de 2015): 329. http://dx.doi.org/10.2967/jnumed.114.153353.

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3

Li, King C. P., Sunil D. Pandit, Samira Guccione y Mark D. Bednarski. "Molecular Imaging Applications in Nanomedicine". Biomedical Microdevices 6, n.º 2 (junio de 2004): 113–16. http://dx.doi.org/10.1023/b:bmmd.0000031747.05317.81.

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4

Hildebrandt, Isabel Junie y Sanjiv Sam Gambhir. "Molecular imaging applications for immunology". Clinical Immunology 111, n.º 2 (mayo de 2004): 210–24. http://dx.doi.org/10.1016/j.clim.2003.12.018.

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5

Petrik, Milos, Chuangyan Zhai, Hubertus Haas y Clemens Decristoforo. "Siderophores for molecular imaging applications". Clinical and Translational Imaging 5, n.º 1 (11 de octubre de 2016): 15–27. http://dx.doi.org/10.1007/s40336-016-0211-x.

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6

Heneweer, Carola y Jan Grimm. "Clinical applications in molecular imaging". Pediatric Radiology 41, n.º 2 (3 de diciembre de 2010): 199–207. http://dx.doi.org/10.1007/s00247-010-1902-5.

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7

James, Michelle L. y Sanjiv S. Gambhir. "A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications". Physiological Reviews 92, n.º 2 (abril de 2012): 897–965. http://dx.doi.org/10.1152/physrev.00049.2010.

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Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecular imaging agents (i.e., small molecules, peptides, aptamers, engineered proteins, and nanoparticles) and cite examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics (therapy combined with diagnostics). A step-by-step guide to answering biological and/or clinical questions using the tools of molecular imaging is also provided. We conclude by discussing the grand challenges of the field, its future directions, and enormous potential for further impacting how we approach research and medicine.

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8

Cai, Jiong, Zhaofei Liu, Fan Wang y Fang Li. "Phage Display Applications for Molecular Imaging". Current Pharmaceutical Biotechnology 11, n.º 6 (1 de septiembre de 2010): 603–9. http://dx.doi.org/10.2174/138920110792246573.

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9

Zhao, Ming, Xuefeng Wang, Gregory M. Lawrence, Patricio Espinoza y David D. Nolte. "Molecular Interferometric Imaging for Biosensor Applications". IEEE Journal of Selected Topics in Quantum Electronics 13, n.º 6 (2007): 1680–90. http://dx.doi.org/10.1109/jstqe.2007.911002.

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10

Mountz, John D., Hui-Chen Hsu, Qi Wu, Hong-Gang Liu, Huang-Ge Zhang y James M. Mountz. "Molecular imaging: New applications for biochemistry". Journal of Cellular Biochemistry 87, S39 (2002): 162–71. http://dx.doi.org/10.1002/jcb.10434.

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11

Blankenberg, Francis G. y H. William Strauss. "Nuclear medicine applications in molecular imaging". Journal of Magnetic Resonance Imaging 16, n.º 4 (25 de septiembre de 2002): 352–61. http://dx.doi.org/10.1002/jmri.10171.

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12

Chen, Zhi-Yi, Yi-Xiang Wang, Yan Lin, Jin-Shan Zhang, Feng Yang, Qiu-Lan Zhou y Yang-Ying Liao. "Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy". BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/819324.

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Molecular imaging is an emerging field that integrates advanced imaging technology with cellular and molecular biology. It can realize noninvasive and real time visualization, measurement of physiological or pathological process in the living organism at the cellular and molecular level, providing an effective method of information acquiring for diagnosis, therapy, and drug development and evaluating treatment of efficacy. Molecular imaging requires high resolution and high sensitive instruments and specific imaging agents that link the imaging signal with molecular event. Recently, the application of new emerging chemical technology and nanotechnology has stimulated the development of imaging agents. Nanoparticles modified with small molecule, peptide, antibody, and aptamer have been extensively applied for preclinical studies. Therapeutic drug or gene is incorporated into nanoparticles to construct multifunctional imaging agents which allow for theranostic applications. In this review, we will discuss the characteristics of molecular imaging, the novel imaging agent including targeted imaging agent and multifunctional imaging agent, as well as cite some examples of their application in molecular imaging and therapy.

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13

Silindir, Mine, Suna Erdoğan, A. Yekta Özer y Serge Maia. "Liposomes and their applications in molecular imaging". Journal of Drug Targeting 20, n.º 5 (4 de mayo de 2012): 401–15. http://dx.doi.org/10.3109/1061186x.2012.685477.

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14

Miller, Tom. "PET: Molecular Imaging and Its Biological Applications." American Journal of Roentgenology 184, n.º 4 (abril de 2005): 1366. http://dx.doi.org/10.2214/ajr.184.4.01841366.

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15

Son, Joo-Hiuk. "Principle and applications of terahertz molecular imaging". Nanotechnology 24, n.º 21 (25 de abril de 2013): 214001. http://dx.doi.org/10.1088/0957-4484/24/21/214001.

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16

Mahmood, U. "Near infrared optical applications in molecular imaging". IEEE Engineering in Medicine and Biology Magazine 23, n.º 4 (julio de 2004): 58–66. http://dx.doi.org/10.1109/memb.2004.1337950.

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17

Chatterjee, Sushmita. "Applications of lentiviral vectors in molecular imaging". Frontiers in Bioscience 19, n.º 6 (2014): 835. http://dx.doi.org/10.2741/4251.

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18

de la Zerda, Adam. "Photoacoustic Molecular Imaging and its Biophysical Applications". Biophysical Journal 104, n.º 2 (enero de 2013): 185a. http://dx.doi.org/10.1016/j.bpj.2012.11.1044.

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19

Shirshahi, Vahid y Madjid Soltani. "Solid silica nanoparticles: applications in molecular imaging". Contrast Media & Molecular Imaging 10, n.º 1 (3 de julio de 2014): 1–17. http://dx.doi.org/10.1002/cmmi.1611.

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20

Du, Meng, Ting Wang, Yaozhang Yang, Fengyi Zeng, Yue Li y Zhiyi Chen. "Application of Genetically Encoded Molecular Imaging Probes in Tumor Imaging". Contrast Media & Molecular Imaging 2022 (27 de agosto de 2022): 1–9. http://dx.doi.org/10.1155/2022/5473244.

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In recent years, imaging technology has made rapid progress to improve the sensitivity of tumor diagnostic. With the development of genetic engineering and synthetic biology, various genetically encoded molecular imaging probes have also been extensively developed. As a biomedical imaging method with excellent detectable sensitivity and spatial resolution, genetically encoded molecular imaging has great application potential in the visualization of cellular and molecular functions during tumor development. Compared to chemosynthetic dyes and nanoparticles with an imaging function, genetically encoded molecular imaging probes can more easily label specific cells or proteins of interest in tumor tissues and have higher stability and tissue contrast in vivo. Therefore, genetically encoded molecular imaging probes have attracted increasing attention from researchers in engineering and biomedicine. In this review, we aimed to introduce the genetically encoded molecular imaging probes and further explained their applications in tumor imaging.

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21

Kircher, Moritz F. y Jürgen K. Willmann. "Molecular Body Imaging: MR Imaging, CT, and US. Part II. Applications". Radiology 264, n.º 2 (agosto de 2012): 349–68. http://dx.doi.org/10.1148/radiol.12111703.

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22

Tian, M. "Molecular Imaging of Small Animals: Instrumentation and Applications". Journal of Nuclear Medicine 56, n.º 7 (29 de mayo de 2015): 1130. http://dx.doi.org/10.2967/jnumed.115.161281.

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23

Iyer, Meera, Makoto Sato, Mai Johnson, Sanjiv Gambhir y Lily Wu. "Applications of Molecular Imaging in Cancer Gene Therapy". Current Gene Therapy 5, n.º 6 (1 de diciembre de 2005): 607–18. http://dx.doi.org/10.2174/156652305774964695.

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24

Williams, Stephen R., Laura Hausmann y Jörg B. Schulz. "Molecular imaging and its applications: visualization beyond imagination". Journal of Neurochemistry 127, n.º 5 (30 de octubre de 2013): 575–77. http://dx.doi.org/10.1111/jnc.12445.

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25

Hicks, Rodney J. "Clinical applications of molecular imaging in sarcoma evaluation". Cancer Imaging 5, n.º 1 (2005): 66–72. http://dx.doi.org/10.1102/1470-7330.2005.0008.

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26

Sasaki, Makoto. "Magnetic resonance molecular imaging: applications to stroke management". Nosotchu 30, n.º 6 (2008): 822–24. http://dx.doi.org/10.3995/jstroke.30.822.

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27

Hazle, J., L. Clarke, E. Jackson y J. Humm. "TU-D-330D-01: Molecular Imaging II - Applications". Medical Physics 33, n.º 6Part17 (junio de 2006): 2197. http://dx.doi.org/10.1118/1.2241554.

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28

Li, Junwei, Jie Liu, Chen-Wei Wei, Bin Liu, Matthew O'Donnell y Xiaohu Gao. "Emerging applications of conjugated polymers in molecular imaging". Physical Chemistry Chemical Physics 15, n.º 40 (2013): 17006. http://dx.doi.org/10.1039/c3cp51763b.

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29

Vishal, Thumar, MD, Liu, MD Ji-Bin y Eisenbrey, PhD John. "Applications in Molecular Ultrasound Imaging: Present and Future". ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY 3, n.º 3 (2019): 62. http://dx.doi.org/10.37015/audt.2019.190812.

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30

Dimayuga, Vanessa M. y Martin Rodriguez-Porcel. "Molecular Imaging of Cell Therapy for Gastroenterologic Applications". Pancreatology 11, n.º 4 (agosto de 2011): 414–27. http://dx.doi.org/10.1159/000327395.

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31

Wu, Cuichen Sam, Lu Peng, Mingxu You, Da Han, Tao Chen, Kathryn R. Williams, Chaoyong James Yang y Weihong Tan. "Engineering Molecular Beacons for Intracellular Imaging". International Journal of Molecular Imaging 2012 (6 de noviembre de 2012): 1–10. http://dx.doi.org/10.1155/2012/501579.

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Molecular beacons (MBs) represent a class of nucleic acid probes with unique DNA hairpin structures that specifically target complementary DNA or RNA. The inherent “OFF” to “ON” signal transduction mechanism of MBs makes them promising molecular probes for real-time imaging of DNA/RNA in living cells. However, conventional MBs have been challenged with such issues as false-positive signals and poor biostability in complex cellular matrices. This paper describes the novel engineering steps used to improve the fluorescence signal and reduce to background fluorescence, as well as the incorporation of unnatural nucleotide bases to increase the resistance of MBs to nuclease degradation for application in such fields as chemical analysis, biotechnology, and clinical medicine. The applications of these de novo MBs for single-cell imaging will be also discussed.

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32

Cassidy, Paul J. y George K. Radda. "Molecular imaging perspectives". Journal of The Royal Society Interface 2, n.º 3 (10 de mayo de 2005): 133–44. http://dx.doi.org/10.1098/rsif.2005.0040.

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Molecular imaging is an emerging technology at the life science/physical science interface which is set to revolutionize our understanding and treatment of disease. The tools of molecular imaging are the imaging modalities and their corresponding contrast agents. These facilitate interaction with a biological target at a molecular level in a number of ways. The diverse nature of molecular imaging requires knowledge from both the life and physical sciences for its successful development and implementation. The aim of this review is to introduce the subject of molecular imaging from both life science and physical science perspectives. However, we will restrict our coverage to the prominent in vivo molecular imaging modalities of magnetic resonance imaging, optical imaging and nuclear imaging. The physical basis of these imaging modalities, the use of contrast agents and the imaging parameters of sensitivity, temporal resolution and spatial resolution are described. Then, the specificity of contrast agents for targeting and sensing molecular events, and some applications of molecular imaging in biology and medicine are given. Finally, the diverse nature of molecular imaging and its reliance on interdisciplinary collaboration is discussed.

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33

Köse, Gurbet, Milita Darguzyte y Fabian Kiessling. "Molecular Ultrasound Imaging". Nanomaterials 10, n.º 10 (28 de septiembre de 2020): 1935. http://dx.doi.org/10.3390/nano10101935.

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In the last decade, molecular ultrasound imaging has been rapidly progressing. It has proven promising to diagnose angiogenesis, inflammation, and thrombosis, and many intravascular targets, such as VEGFR2, integrins, and selectins, have been successfully visualized in vivo. Furthermore, pre-clinical studies demonstrated that molecular ultrasound increased sensitivity and specificity in disease detection, classification, and therapy response monitoring compared to current clinically applied ultrasound technologies. Several techniques were developed to detect target-bound microbubbles comprising sensitive particle acoustic quantification (SPAQ), destruction-replenishment analysis, and dwelling time assessment. Moreover, some groups tried to assess microbubble binding by a change in their echogenicity after target binding. These techniques can be complemented by radiation force ultrasound improving target binding by pushing microbubbles to vessel walls. Two targeted microbubble formulations are already in clinical trials for tumor detection and liver lesion characterization, and further clinical scale targeted microbubbles are prepared for clinical translation. The recent enormous progress in the field of molecular ultrasound imaging is summarized in this review article by introducing the most relevant detection technologies, concepts for targeted nano- and micro-bubbles, as well as their applications to characterize various diseases. Finally, progress in clinical translation is highlighted, and roadblocks are discussed that currently slow the clinical translation.

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34

Cepeda, Eduardo y Katherine Narváez. "Molecular Photoacoustic Imaging". Bionatura 6, n.º 4 (15 de noviembre de 2021): 2351–55. http://dx.doi.org/10.21931/rb/2021.06.04.34.

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Medicine has gone through several challenges to make it much more accurate and thus prolong the human being's life. A large part of this challenge is diseased, so early detection can help carry out treatment on time. There is a technology that allows detecting an abnormality within the body without using an invasive method. Ultrasound is a diagnostic test used to scan organs and tissues through sound waves. Although this technique has been widely used, the results are not desired because the images generated are not high resolution. On the other hand, X-rays are used because it presents an image with a much higher resolution than other techniques based on light waves or ultrasound; despite this, they are harmful to cells. In consequence of this problem, another method called molecular photoacoustic imaging has been implemented. This technique bridges the traditional depth limits of ballistic optical imaging and diffuse optical imaging's resolution limits, using the acoustic waves generated in response to laser light absorption, which has now shown potential for molecular imaging, allowing the visualization of biological processes in a non-invasive way. The purpose of this article is to give a critically scoped review of the physical, chemical, and biochemical characteristics of existing photoacoustic contrast agents, highlighting the pivotal applications and current challenges for molecular photoacoustic imaging.

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35

He, Cailing, Jiayuan Zhu, Huayue Zhang, Ruirui Qiao y Run Zhang. "Photoacoustic Imaging Probes for Theranostic Applications". Biosensors 12, n.º 11 (1 de noviembre de 2022): 947. http://dx.doi.org/10.3390/bios12110947.

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Photoacoustic imaging (PAI), an emerging biomedical imaging technology, capitalizes on a wide range of endogenous chromophores and exogenous contrast agents to offer detailed information related to the functional and molecular content of diseased biological tissues. Compared with traditional imaging technologies, PAI offers outstanding advantages, such as a higher spatial resolution, deeper penetrability in biological tissues, and improved imaging contrast. Based on nanomaterials and small molecular organic dyes, a huge number of contrast agents have recently been developed as PAI probes for disease diagnosis and treatment. Herein, we report the recent advances in the development of nanomaterials and organic dye-based PAI probes. The current challenges in the field and future research directions for the designing and fabrication of PAI probes are proposed.

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36

Kumamoto, Yasuaki, Menglu Li, Kota Koike y Katsumasa Fujita. "Slit-scanning Raman microscopy: Instrumentation and applications for molecular imaging of cell and tissue". Journal of Applied Physics 132, n.º 17 (7 de noviembre de 2022): 171101. http://dx.doi.org/10.1063/5.0102079.

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In recent years, Raman microscopy has emerged as a molecular imaging tool for cell and tissue analysis. A key reason for this is the development of techniques that significantly increase imaging speed. In this Tutorial, we introduce slit-scanning Raman microscopy, a Raman imaging technique that achieves imaging speeds more than two orders of magnitude faster than conventional confocal Raman microscopy, and its application to cell and tissue imaging and analysis. Recent advances in Raman imaging, particularly further improvements in imaging speed, sensitivity, specificity, and spatial resolution, are also discussed. In addition, we present the prospects of Raman microscopy as a molecular imaging method to aid in new discoveries in life sciences and the potential of high-speed Raman imaging for clinical applications.

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37

Catrysse, Peter B., Francisco H. Imai, Dale C. Linne von Berg y John T. Sheridan. "Imaging systems and applications". Applied Optics 52, n.º 7 (28 de febrero de 2013): ISA1. http://dx.doi.org/10.1364/ao.52.00isa1.

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38

Aljabali, Alaa A. A. y Mohammad A. Obeid. "Inorganic-organic Nanomaterials for Therapeutics and Molecular Imaging Applications". Nanoscience & Nanotechnology-Asia 10, n.º 6 (30 de noviembre de 2020): 748–65. http://dx.doi.org/10.2174/2210681209666190807145229.

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Background:: Surface modification of nanoparticles with targeting moieties can be achieved through bioconjugation chemistries to impart new Functionalities. Various polymeric nanoparticles have been used for the formulation of nanoparticles such as naturally-occurring protein cages, virus-like particles, polymeric saccharides, and liposomes. These polymers have been proven to be biocompatible, side effects free and degradable with no toxicity. Objectives:: This paper reviews available literature on the nanoparticles pharmaceutical and medical applications. The review highlights and updates the customized solutions for selective drug delivery systems that allow high-affinity binding between nanoparticles and the target receptors. Methods:: Bibliographic databases and web-search engines were used to retrieve studies that assessed the usability of nanoparticles in the pharmaceutical and medical fields. Data were extracted on each system in vivo and in vitro applications, its advantages and disadvantages, and its ability to be chemically and genetically modified to impart new functionalities. Finally, a comparison between naturally occurring and their synthetic counterparts was carried out. Results:: The results showed that nanoparticles-based systems could have promising applications in diagnostics, cell labeling, contrast agents (Magnetic Resonance Imaging and Computed Tomography), antimicrobial agents, and as drug delivery systems. However, precautions should be taken to avoid or minimize toxic effect or incompatibility of nanoparticles-based systems with the biological systems in case of pharmaceutical or medical applications. Conclusion:: This review presented a summary of recent developments in the field of pharmaceutical nanotechnology and highlighted the challenges and the merits that some of the nanoparticles- based systems both in vivo and in vitro systems.

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39

Harada, Yoshinori y Tetsuro Takamatsu. "Editorial [Hot Topic Biomedical Applications of Molecular Vibrational Imaging]". Current Pharmaceutical Biotechnology 14, n.º 2 (1 de febrero de 2013): 131–32. http://dx.doi.org/10.2174/1389201011314020001.

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40

Harada, Yoshinori y Tetsuro Takamatsu. "Editorial (Hot Topic: Biomedical Applications of Molecular Vibrational Imaging)". Current Pharmaceutical Biotechnology 14, n.º 2 (1 de febrero de 2013): 131–32. http://dx.doi.org/10.2174/138920113805219421.

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41

Penet, Marie-France, Maria Mikhaylova, Cong Li, Balaji Krishnamachary, Kristine Glunde, Arvind P. Pathak y Zaver M. Bhujwalla. "Applications of molecular MRI and optical imaging in cancer". Future Medicinal Chemistry 2, n.º 6 (junio de 2010): 975–88. http://dx.doi.org/10.4155/fmc.10.25.

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42

Gimi, B., A. P. Pathak, E. Ackerstaff, K. Glunde, D. Artemov y Z. M. Bhujwalla. "Molecular Imaging of Cancer: Applications of Magnetic Resonance Methods". Proceedings of the IEEE 93, n.º 4 (abril de 2005): 784–99. http://dx.doi.org/10.1109/jproc.2005.844266.

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43

Shim, Chi Young y Jonathan R. Lindner. "Cardiovascular Molecular Imaging with Contrast Ultrasound: Principles and Applications". Korean Circulation Journal 44, n.º 1 (2014): 1. http://dx.doi.org/10.4070/kcj.2014.44.1.1.

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44

Abou, D. S., J. E. Pickett y D. L. J. Thorek. "Nuclear molecular imaging with nanoparticles: radiochemistry, applications and translation". British Journal of Radiology 88, n.º 1054 (octubre de 2015): 20150185. http://dx.doi.org/10.1259/bjr.20150185.

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45

Zhang, Rui, Liangliang Zhang, Tong Wu, Ruixue Wang, Shasha Zuo, Dong Wu, Cunlin Zhang, Jue Zhang y Jing Fang. "Continuous-terahertz-wave molecular imaging system for biomedical applications". Journal of Biomedical Optics 21, n.º 7 (12 de julio de 2016): 076006. http://dx.doi.org/10.1117/1.jbo.21.7.076006.

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46

Feng, Jinchao, Wenxiang Cong, Kuangyu Shi, Shouping Zhu y Jun Zhang. "Translational Molecular Imaging Computing: Advances in Theories and Applications". BioMed Research International 2016 (2016): 1–2. http://dx.doi.org/10.1155/2016/1569605.

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47

Reichert, D. "Applications of molecular mechanics to metal-based imaging agents". Coordination Chemistry Reviews 212, n.º 1 (febrero de 2001): 111–31. http://dx.doi.org/10.1016/s0010-8545(00)00367-2.

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48

Mezzanotte, Laura, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun y Clemens W. G. M. Löwik. "In Vivo Molecular Bioluminescence Imaging: New Tools and Applications". Trends in Biotechnology 35, n.º 7 (julio de 2017): 640–52. http://dx.doi.org/10.1016/j.tibtech.2017.03.012.

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49

Ajito, Katsuhiro, Yuko Ueno, Ho-Jin Song, Emi Tamechika y Naoya Kukutsu. "Terahertz Chemical Imaging of Molecular Networks for Pharmaceutical Applications". ECS Transactions 35, n.º 7 (16 de diciembre de 2019): 157–65. http://dx.doi.org/10.1149/1.3571988.

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50

Delli Castelli, Daniela, Eliana Gianolio, Simonetta Geninatti Crich, Enzo Terreno y Silvio Aime. "Metal containing nanosized systems for MR-Molecular Imaging applications". Coordination Chemistry Reviews 252, n.º 21-22 (noviembre de 2008): 2424–43. http://dx.doi.org/10.1016/j.ccr.2008.05.006.

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