Literatura académica sobre el tema "Modular PKS engineering"
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Artículos de revistas sobre el tema "Modular PKS engineering"
Beck, Charlotte, Jaime Felipe Guerrero Garzón y Tilmann Weber. "Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines". Biotechnology and Bioprocess Engineering 25, n.º 6 (diciembre de 2020): 886–94. http://dx.doi.org/10.1007/s12257-020-0265-5.
Texto completoWesener, Shane R., Vishwakanth Y. Potharla y Yi-Qiang Cheng. "Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase". Applied and Environmental Microbiology 77, n.º 4 (23 de diciembre de 2010): 1501–7. http://dx.doi.org/10.1128/aem.01513-10.
Texto completoMusiol-Kroll, Ewa y Wolfgang Wohlleben. "Acyltransferases as Tools for Polyketide Synthase Engineering". Antibiotics 7, n.º 3 (18 de julio de 2018): 62. http://dx.doi.org/10.3390/antibiotics7030062.
Texto completoRascher, Andreas, Zhihao Hu, Greg O. Buchanan, Ralph Reid y C. Richard Hutchinson. "Insights into the Biosynthesis of the Benzoquinone Ansamycins Geldanamycin and Herbimycin, Obtained by Gene Sequencing and Disruption". Applied and Environmental Microbiology 71, n.º 8 (agosto de 2005): 4862–71. http://dx.doi.org/10.1128/aem.71.8.4862-4871.2005.
Texto completoHe, Yunlong, Yuhui Sun, Tiangang Liu, Xiufen Zhou, Linquan Bai y Zixin Deng. "Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification". Applied and Environmental Microbiology 76, n.º 10 (26 de marzo de 2010): 3283–92. http://dx.doi.org/10.1128/aem.02262-09.
Texto completoHaydock, Stephen F., Anthony N. Appleyard, Tatiana Mironenko, John Lester, Natasha Scott y Peter F. Leadlay. "Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449". Microbiology 151, n.º 10 (1 de octubre de 2005): 3161–69. http://dx.doi.org/10.1099/mic.0.28194-0.
Texto completoAgergaard, Julie Krogh, Kristoffer Wernblad Sigsgaard, Niels Henrik Mortensen, Simon Didriksen, Kasper Barslund Hansen y Jingrui Ge. "MODULAR MAINTENANCE DECISION ARCHITECTURE". Proceedings of the Design Society 3 (19 de junio de 2023): 2715–24. http://dx.doi.org/10.1017/pds.2023.272.
Texto completoWang, Guimei, Lijie Yang y Yong Shuo Zhang. "Modularized design of coal-mine paste filling station based on fuzzy theory". World Journal of Engineering 15, n.º 6 (3 de diciembre de 2018): 743–50. http://dx.doi.org/10.1108/wje-01-2018-0006.
Texto completoRana, Vighneshkumar y Vishal Singh. "Analyzing the dimensional aspects of 3D volumetric spaces: a product-oriented perspective". Proceedings of the Design Society 4 (mayo de 2024): 2433–42. http://dx.doi.org/10.1017/pds.2024.246.
Texto completoBreimann, Richard, Christoph Rennpferdt, Sven Wehrend, Eckhard Kirchner y Dieter Krause. "EXPLOITING THE SUSTAINABILITY POTENTIAL OF MODULAR PRODUCTS BY INTEGRATING R-IMPERATIVES INTO PRODUCT LIFE PHASES". Proceedings of the Design Society 3 (19 de junio de 2023): 1785–94. http://dx.doi.org/10.1017/pds.2023.179.
Texto completoTesis sobre el tema "Modular PKS engineering"
Su, Li. "Generation of analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches". Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0081.
Texto completoThe polyketide secondary metabolites of bacteria are a rich source of bioactive agents, with notable applications in anti-infective and anti-cancer therapy. However, their structures often need to be optimized in order to tailor their therapeutic and biophysical properties. The 51-membered macrolide stambomycins, among the largest of known polyketides, were recently discovered by genome mining in Streptomyces ambofaciens ATCC23877, and notably exhibit promising anti-cancer activity. The family encompasses six members which differ from each other in the alkyl functionality at C-26, due to the alternative choice of extender units by an exceptional acyl transferase domain (AT12) of the modular polyketide synthase (PKS) responsible for synthesizing the stambomycin core. Given their enormous size of the stambomycins and the intrinsic promiscuity of AT12, there is substantial interest in accessing ring-contracted and C-26 substituted derivatives of this compounds which might retain the bioactivity of the parental structures, or exhibit improved or even new properties. In this work, we have leveraged our current understanding of modular PKS systems to internally contract the stambomycin assembly line, leading to the successful generation, albeit at low yield, of target smaller derivatives (37-membered ‘mini-stambomycins’). By careful analysis, we could identify multiple factors contributing to the low titers, information which should inform future engineering strategies. Furthermore, using a mutasynthesis strategy, we were able to exploit the broad specificity of the AT12 domain to create 6 novel C-26 substituted stambomycin analogues. Finally, we unexpectedly identified three series of novel desferrioxamine siderophores produced by S. ambofaciens. As a number of key metabolites generated in this work have potential interest for therapeutic applications, they will be targeted for purification, structural characterization and biological evaluation
Zarzoso, Vicente. "Traitement aveugle et semi-aveugle du signal pour les télécommunications et le génie biomédical". Habilitation à diriger des recherches, Université de Nice Sophia-Antipolis, 2009. http://tel.archives-ouvertes.fr/tel-00486872.
Texto completoCapítulos de libros sobre el tema "Modular PKS engineering"
JianBing, Chen. "PEEK and PES ☆". En Reference Module in Materials Science and Materials Engineering. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-803581-8.02607-2.
Texto completoGlinsky, Albert. "A Eunuch in a Harem". En Switched On, 80—C8.P38. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/oso/9780197642078.003.0008.
Texto completoSubirats, X., E. Fuguet, M. Rosés, E. Bosch y C. Ràfols. "Methods for pKa Determination (I): Potentiometry, Spectrophotometry, and Capillary Electrophoresis". En Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11559-8.
Texto completoQin, Weijin, Ya Liu y Xuhai Yang. "Performance Analysis on a Traceable Precise Satellite Timing". En Advances in Transdisciplinary Engineering. IOS Press, 2022. http://dx.doi.org/10.3233/atde221204.
Texto completoFuguet, E., X. Subirats, C. Ràfols, E. Bosch y M. Rosés. "Methods for pKa Determination (II): Sparingly Soluble Compounds and High-Throughput Approaches". En Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11631-2.
Texto completoActas de conferencias sobre el tema "Modular PKS engineering"
Zhang, Dan, Lihui Wang y Sherman Y. T. Lang. "Modelling and Control of PKM in an Integrated Environment". En ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/cie-48178.
Texto completoKitzmiller, John T., Richard G. Anderson, Laura L. Genutis y Dennis M. Popp. "Effects on Core Damage Frequency to Sensitivity of Instrumentation and Control Reliability". En 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75413.
Texto completoHan, Changwan, Seonghun Park y Hanjong Kim. "Dynamic Response of Polyvinyl Alcohol(PVA)-Hydrogel With Different PVA Concentrations". En ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37811.
Texto completoEilmus, Sandra y Dieter Krause. "Product Life-Oriented Development of Component Commonality and Variety". En ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-63619.
Texto completoMüller, Andreas. "A Lie Group Approach to the Modular Modeling of Kinematically Non-Redundant Parallel Mechanisms". En ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-98283.
Texto completoZhang, Dan, Lihui Wang y Sherman Y. T. Lang. "An Integrated Virtual Validation System for Parallel Kinematic Machine Analysis Design". En ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/dac-48825.
Texto completoChen, Hui y Zhixing Wang. "Computer Aided Manufacturing of Marine Propellers by Parallel Kinematics Machine". En ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-41727.
Texto completoPradhan, A. K., A. Routray y A. Behera. "Power quality disturbance classification employing modular wavelet network". En 2006 IEEE Power Engineering Society General Meeting. IEEE, 2006. http://dx.doi.org/10.1109/pes.2006.1709452.
Texto completoWehlin, Camilla, Olle Vidner, Leon Poot y Mehdi Tarkian. "Integrating Sales, Design and Production: A Configuration System for Automation in Mass Customization". En ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-68426.
Texto completoYu, Mingrui, Hongliang Wang, Zhuo Liu, Yu Feng, Xu Han y Yidan Yuan. "Experimental Research on Drag Characteristic of Air Flow Path for ACP-100 Passive Containment Air Cooling System". En 2022 29th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/icone29-91504.
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