Tesis sobre el tema "Mitotic spindle orientations"
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Dunsch, Anja Katrin. "Control of the mitotic spindle by dynein light chain 1 complexes". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:b2fd5670-a035-42ca-aaef-78a30aeaa084.
Texto completoHüls, Daniela. "Structural and functional studies on mitotic spindle orientation in Saccharomyces cerevisiae". Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-141524.
Texto completoGolub, Ognjen. "Molecular Mechanisms Regulating Subcellular Localization and Function of Mitotic Spindle Orientation Determinants". Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/20711.
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Lu, Michelle. "The Construction and Deconstruction of Signaling Systems that Regulate Mitotic Spindle Positioning". Thesis, University of Oregon, 2013. http://hdl.handle.net/1794/12955.
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Lopes, Cláudia Sofia de Jesus. "Molecular partners for Bud6p-mediated orientation of the mitotic spindle in S. cerevisiae". Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608848.
Texto completoVodicska, Barbara [Verfasser] y Ingrid [Akademischer Betreuer] Hoffmann. "Deciphering the function of MISP in mitotic spindle orientation / Barbara Vodicska ; Betreuer: Ingrid Hoffmann". Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/117704370X/34.
Texto completoFernández, Baldovinos Javier [Verfasser] y Thomas [Akademischer Betreuer] Worzfeld. "Mechanisms of Mitotic Spindle Orientation by Plexin-B2 / Javier Fernández Baldovinos ; Betreuer: Thomas Worzfeld". Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/1228535744/34.
Texto completoPenisson, Maxime. "Mécanismes de LIS1 dans les progéniteurs neuraux contribuant aux malformations de développement du cortex". Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS415.
Texto completoHuman cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Basal radial glia (bRGs), a type of progenitor cells, are limited in lissencephalic species (e.g. the mouse) but abundant in gyrencephalic brains. The LIS1 gene coding for a dynein regulator, is mutated in human lissencephaly, associated also in some cases with microcephaly. LIS1 was shown to be important during cell division and neuronal migration. Here, we generated bRG-like cells in the mouse embryonic brain, investigating the role of Lis1 in their formation. This was achieved by in utero electroporation of a hominoid-specific gene TBC1D3 at mouse embryonic day (E) 14.5. We first confirmed that TBC1D3 overexpression in WT brain generates numerous Pax6+ bRG-like cells that are basally localized. Second, we assessed the formation of these cells in heterozygote Lis1 mutant brains. Our novel results show that Lis1 depletion in the forebrain from E9.5 prevented subsequent TBC1D3-induced bRG-like cell amplification. Lis1 depletion changed mitotic spindle orientations at the ventricular surface, increased the proportion of abventricular mitoses, and altered N-Cadherin expression, altering TBC1D3 function. We conclude that perturbation of Lis1/LIS1 dosage is likely to be detrimental for appropriate progenitor number and position, contributing to lissencephaly pathogenesis
Hüls, Daniela [Verfasser] y Klaus [Akademischer Betreuer] Förstemann. "Structural and functional studies on mitotic spindle orientation in Saccharomyces cerevisiae / Daniela Hüls. Betreuer: Klaus Förstemann". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1021307645/34.
Texto completoQuyn, Aaron J. "The role of the APC protein in mitotic spindle orientation and tissue organisation in gut epithelium". Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505629.
Texto completoSchermuly, Nadine [Verfasser]. "Regulation Of Spindle Orientation By A Mitotic Actin Pathway In Chromosomally Unstable Cancer Cells / Nadine Schermuly". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1221802402/34.
Texto completoMauser, Jonathon. "Regulatory Mechanisms Governing the Establishment of Cell Polarity and Mitotic Spindle Orientation in the Drosophila Neuroblast". Thesis, University of Oregon, 2014. http://hdl.handle.net/1794/18344.
Texto completoGallini, S. "MOLECULAR CONTRIBUTION OF THE AURORA-A KINASE AND THE JUNCTIONAL PROTEIN AFADIN TO ORIENTED CELL DIVISIONS". Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/354581.
Texto completoNemirovsky, Oksana. "The regulation of mitotic spindle orientation by BRCA1 controls the proliferation, polarization and growth arrest of human mammary epithelia". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50210.
Texto completoMedicine, Faculty of
Medicine, Department of
Experimental Medicine, Division of
Graduate
PIROVANO, LAURA. "NUMA:LGN HETERO-HEXAMERS PROMOTE THE ASSEMBLY OF CORTICAL PROTEIN NETWORK TO CONTROL PLANAR CELL DIVISIONS". Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/697169.
Texto completoPeyre, Elise. "Mécanisme et importance développementale de l'orientation du fuseau mitotique des progéniteurs neuraux chez les vertébrés : rôle du complexe Gαi\LGN\NUMA". Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22079.
Texto completoTo maintain tissue architecture, epithelial cells divide in a planar fashion, perpendicular to their main polarity axis. As the centrosome resumes an apical localization in interphase, planar spindle orientation is reset at each cell cycle. We used three-dimensional live imaging of GFP-labeled centrosomes to investigate the dynamics of spindle orientation in chick neuroepithelial cells. The mitotic spindle displays stereotypic movements during metaphase, with an active phase of planar orientation and a subsequent phase of planar maintenance before anaphase. We describe the localization of the NuMA and LGN proteins in a belt at the lateral cell cortex during spindle orientation. Finally, we show that the complex formed of LGN, NuMA, and of cortically located Gái subunits is necessary for spindle movements and regulates the dynamics of spindle orientation. The restricted localization of LGN and NuMA in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance
Ben, M'Barek Karim. "Rôles normal et pathologique des phosphorylations de la huntingtine par Cdk5". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T077/document.
Texto completoHuntington disease (HD) is a fatal neurodegenerative disorder associated with early psychiatric symptoms including anxiety and depression.During my thesis, I have demonstrated that huntingtin, the protein mutated in HD, modulates anxiety/depression-related behaviors through its phosphorylations at serines 1181 and 1201. Indeed, genetic phospho-ablation at serines 1181 and 1201 in mouse reduces basal levels of anxiety/depression-like behaviors in mouse. Suppression of neurogenesis by focal hippocampal irradiation abolishes this reduction of basal levels of anxiety/depression on some behavioral test demonstrating that neurogenesis is involved in this process. Ablation of HTT phosphorylations may stimulate neurogenesis through BDNF transport, release and signaling.I have also shown that ablation of phosphorylations on HTT is sufficient to ameliorate the anxiety/depression-like behavior of a mouse model of HD, which develops a behavior indicative of depression–like state.I have finally explored the role of HTT phosphorylation at serines 1181 and 1201 during brain development. During early steps of cortical neurogenesis, I have shown that ablation of HTT phosphorylations affects the mitosis of cortical progenitors, the fate of newly generated cells and the migration of new neurons.The results obtained during my thesis support the notion that HTT regulates key molecular mechanisms during neurogenesis both in adult and embryo. It also supports the notion that huntingtin participates to anxiety and depression-like behavior with potential consequences for the etiology of mood disorders and anxiety/depression in HD
Schermuly, Nadine. "Regulation Of Spindle Orientation By A Mitotic Actin Pathway In Chromosomally Unstable Cancer Cells". Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-14F2-3.
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