Tesis sobre el tema "Microfluidic devices"
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Fiorini, Gina S. "Polymeric microfluidic devices : development of thermoset polyester microfluidic devices and use of poly(dimethylsiloxane) devices for droplet applications /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8627.
Texto completoGallagher, Sarah. "Microfluidic confinement of responsive systems". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648567.
Texto completoChen, Tian Lan. "Thermal digital microfluidic devices for rapid DNA analysis". Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3691869.
Texto completoSun, Han. "Novel microfluidic platform for bioassays". HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/699.
Texto completoFallahi, Hedieh. "Flexible and Stretchable Microfluidics". Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415361.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environment and Sc
Science, Environment, Engineering and Technology
Full Text
Tsai, Long-Fang. "Microfluidic Devices and Biosensors". BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5821.
Texto completoLi, Yi. "Membrane-Based Protein Preconcentration Microfluidic Devices". Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1216.pdf.
Texto completoBrotherton, C. M. "Mixing in polymeric microfluidic devices". Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3256449.
Texto completoEngland, Pinar. "Droplet behaviour in microfluidic devices". Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30138.
Texto completoSun, Xuefei. "Polymeric microfluidic devices for bioanalysis /". Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd2785.pdf.
Texto completoSun, Xuefei. "Polymer Microfluidic Devices for Bioanalysis". BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/1836.
Texto completoHonnatti, Meghana V. "Microfluidic devices for rapid solution exchange /". free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1426068.
Texto completoRazunguzwa, Trust T. "Development of microfluidic devices for proteomics". Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4691.
Texto completoTitle from document title page. Document formatted into pages; contains xiv, 131 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
Hsu, Chia-Hsien. "Elastomeric microfluidic devices for biological studies /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/7029.
Texto completoShah, Jayna J. "Microfluidic devices for forensic DNA analysis". Fairfax, VA : George Mason University, 2007. http://hdl.handle.net/1920/2878.
Texto completoTitle from PDF t.p. (viewed Jan. 22, 2008). Thesis director: Rao V. Mulpuri. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Electrical and Computer Engineering. Vita: p. 159. Includes bibliographical references (p. 145-158). Also available in print.
Chen, Yanli. "Single cell analysis on microfluidic devices". Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/904.
Texto completoTrahan, Daniel Warner. "Simulating DNA behavior in microfluidic devices". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62109.
Texto completoCataloged from PDF version of thesis.
Includes bibliographical references (p. [109]-115).
During most of the twentieth century, direct study of individual polymer molecules was impossible due to their small size. Therefore, polymers were typically studied in bulk solutions, and their behavior and interactions had to be understood through average bulk property measurements. Because the scale of most industrial applications greatly exceeded the size of these molecules, this level of analysis was satisfactory. In the last twenty years, however, the appearance of microfluidic devices, whose smallest length scales are comparable to the size of a polymer molecule, has offered ways to visually study the behavior of individual polymer molecules and made possible new and exciting applications that exploit the precise control afforded by the small size of these devices. One such application is gene mapping, which extracts, at a. coarse level, the information embedded in the base pair sequence of genomic DNA. This technology relies on the ability to manipulate single DNA molecules in order to perform such tasks as separating DNA based on length and stretching DNA away from its entropically coiled equilibrium state. Recently, many novel methods have been proposed to accomplish these tasks using microfabricated devices, and munch experimental work has been focused on identifying and characterizing the underlying physics governing these devices. Current understanding, however, is greatly hampered by the fact that experiments can only provide limited information about the behavior of DNA molecules (e.g., they are unable to resolve details on small time and length scales). Therefore, simulations are an invaluable tool in the study of DNA behavior in microfiuidic devices by complementing and guiding experimental investigations. In this thesis, we present Brownian Dynamics simulations of the single molecule behavior of DNA in microfluidic devices related to gene mapping. In particular, we have considered the use of a post array to "precondition" the configuration of molecules for subsequent stretching in a contraction and compared our results to previous experiments. We found good qualitative agreement between experiments and simulations for DNA behavior in the post array, but our simulations consistently overpredicted the final stretch of molecules at the end of the contraction, which we attributed to nonlinear electrokinetic effects. We also investigate the electrophoretic collision of a DNA molecule with a. large, ideally conducting post. Field-induced compression was shown to play a critical role in the escape process of a molecule trapped on the post surface, and an extensive theoretical analysis is performed, describing both the local field-induced compression and the larger collision problem. Finally, we study the relaxation process of an initially stretched molecule in slit-like confinement. We present the first simulation results that exhibit two distinct relaxation times in the linear force regime, as previously reported in recent experiments. Our analysis is focused on the experimentally inaccessible dynamics in the transverse directions, particularly at short times and on small length scales. Comparisons to the predictions of a recent mechanistic model of confined relaxation were found to be satisfactory.
by Daniel Warner Trahan.
Ph.D.
Weldegebriel, Amos. "A UV detector for microfluidic devices". Thesis, Kansas State University, 2014. http://hdl.handle.net/2097/17626.
Texto completoDepartment of Chemistry
Christopher T. Culbertson
Chemical separation involves selective movement of a component out of a region shared by multiple components into a region where it is the major occupant. The history of the field of chemical separations as a concept can be dated back to ancient times when people started improving the quality of life by separation of good materials from bad ones. Since then the field of chemical separation has become one of the most continually evolving branches of chemical science and encompasses numerous different techniques and principles. An analytical chemist’s quest for a better way of selective identification and quantification of a component by separating it from its mixture is the cause for these ever evolving techniques. As a result, today there are numerous varieties of analytical techniques for the separation of complex mixtures. High Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Capillary Electrophoresis (CE) and Gel Electrophoresis are a few out of a long list. Each these techniques manipulates the different physical and chemical properties of an analyte to achieve a useful separation and thus certain techniques will be suited for certain molecules. This work primarily focuses on the use of Capillary Electrophoresis as a separation technique. The mechanism of separation in Capillary Zone Electrophoresis and principles of UV detection will discussed in chapter one. Chapter two contains a discussion about the application of Capillary Electrophoresis (CE) on microfluidc devices. This will include sections on: microfabrication techniques of PDMS and photosensitized PDMS (photoPDMS), a UV detector for microfluidic devices and its application for the detection of wheat proteins. In Chapter three we report the experimental part of this project which includes; investigations on the effect of UV exposure time and thermal curing time on feature dimensions of photoPDMS microfluidic device, investigations on the injection and separation performances of the device, characterization of a UV detector set up and its application for the separation and detection of wheat gliadin proteins. The results of these investigations are presented in chapter four.
Beauchamp, Michael J. "3D Printed Microfluidic Devices for Bioanalysis". BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8566.
Texto completoLouw, Clementine Juliat. "Microfluidic paper based electrochemical sensing devices". University of the Western Cape, 2019. http://hdl.handle.net/11394/7000.
Texto completoMicrofluidic paper based electrochemical sensing devices (μPEDs) provides a new way for point of care testing (POCT). μPEDs offer an inexpensive, portable, easy to use technology too monitor the environment and diagnose diseases, especially in developing countries in cases where there is not enough infrastructure and a limited trained medical and health professionals. The aim of this work is to develop a paper based electrode which can be further integrated into a microfluidic paper device to develop miniature point of care devices. Paper was used as a substrate for printing of the electrode because it is found everywhere, inexpensive and it is compatible with a number of chemical, biochemical and medical applications. Polyamic acid (PAA) was incorporated into commercial carbon ink and was used to print the working electrode. The first part of the study was conducted using the commercial screen printed carbon electrodes (SPCE) to study and understand the electrochemical behaviour of PAA. Cobalt nanoparticles and cobalt nanoparticles‐polyamic acid composites were electrochemically deposited onto SPCE. The modified electrodes were characterised using cyclic voltammetry. As synthesised polyamic acid were characterised using Scanning Electron Microscopy (SEM) to evaluate the morphology and chemical composition of polyamic acid. Transmission Electron Microscopy (TEM) was used to study the particle size and chemical composition of cobalt nanoparticles. Fourier Transform Infrared Spectroscopy (FTIR) was used to study the chemical nature of polyamic acid and cyclic voltammetry (CV) was used to study the electrochemical behaviour of polyamic acid and cobalt nanoparticle electrodes. The diffusion coefficients and formal potential of the electrodes were calculated. The modified and bare electrodes were also used to electrochemically detect Norfloxacin in an aqueous solution by CV and square wave voltammetry (SWV) and the analytical performance of the electrochemical systems are reported here. The obtained limit of detection for the bare SPCE was 3.7 x 10‐3 M and 14.7 x 10‐3 M for the PAA‐SPCE.
Hamblin, Mark Noble. "Thin Film Microfluidic and Nanofluidic Devices". BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2281.
Texto completoBARBARESCO, FEDERICA. "Microfluidic devices: application for liquid biopsy". Doctoral thesis, Politecnico di Torino, 2021. http://hdl.handle.net/11583/2903504.
Texto completoHuffman, Jamie. "Design of a microfluidic device for lymphatic biology". Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42886.
Texto completoCartas, Ayala Marco Aurelio. "Fabrication process for openable microfluidic devices and externally actuated microfluidic switch". Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46057.
Texto completoIncludes bibliographical references (leaves 140-142).
In this document I discuss the fabrication of metallic, aluminum and aluminum oxide, 3D micro channels, made with standard milling technology, along with two channel closing methods for openable devices: half cured-glued PDMS and Pressure Sensitive Adhesive (PSA) Film. Using the aluminum oxide coated micro channels, along with the half cured-glued PDMS process to close the channels and external fast speed valves for actuation, a microfluidic switch for cell sorting capable of operating at 48 Hz was designed, fabricated and tested. The use of aluminum as a channel substrate provides channel strength and short heat dissipation times, and the use of aluminum oxide enhances light energy absorption, which provides the possibility of further laser actuation. Also, the combination of micro fabrication process and actuation technique makes possible the further scaling and handling of large cells as cardiocytes.
by Marco Aurelio Cartas Ayala.
S.M.
Liu, Jikun. "Fabrication of Polymeric Microfluidic Devices for Protein Analysis". Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1325.pdf.
Texto completoBien, D. C. S. "Micromachined valves and pump for microfluidic applications". Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269168.
Texto completoJong, Jorrit de. "Application of membrane technology in microfluidic devices". Enschede : University of Twente [Host], 2008. http://doc.utwente.nl/58919.
Texto completoBennet, Mathieu A. "Multi-parameter quantitative mapping of microfluidic devices". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5739.
Texto completoDu, X. "Surface acoustic wave devices for microfluidic applications". Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598662.
Texto completoSchabmüller, Christian Georg Johann. "Microfluidic devices for integrated bio/chemical systems". Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396200.
Texto completoPark, Hyesung Ph D. Massachusetts Institute of Technology. "Fabrication of microfluidic devices for artificial respiration". Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40370.
Texto completoIncludes bibliographical references (p. 101-108).
We are developing elastomeric polydimethylsiloxane (PDMS) microfluidic devices incorporated with photoactive thin films to create an implantable artificial respiration platform. Whereas state-of-the-art respiration support machines deliver oxygen gas directly to the blood via external macroscale devices, our technique utilizes a biomimetic photocatalytic process to generate energy from light and thus produce dissolved oxygen from water which is already present in the blood. Blood oxygenation will be achieved by the interaction between the photoactivated metal oxide film and blood in the setting of a molded microfluidic conduit, providing a stable and implantable oxygenation platform. As a basic, scalable building block, we developed a noble "network" design which was structurally similar to the native pulmonary capillary network. The interconnected channel geometry was designed in such a way to minimize shear stress and reduce hemolysis and thrombosis inside the microchannel. It allowed alternative flow pathways in the event of single channel occlusion while minimizing the establishment of detrimental pressure gradients. The hemocompatibility analysis demonstrated that the network construct showed acceptable levels of hemolysis rate (< 8%) and thrombus formation.
(cont.) Critical to the success of this project is the understanding of the manufacture parameters for microfluidic devices molded from elastomeric materials like PDMS. In the initial development of our work, we performed the following three tasks to generate manufacture protocols for elastomeric microfluidic devices that will be ultimately used for biological applications: 1) Curing schedules of the heat-cure PDMS elastomers under various fabrication parameters were characterized. 2) The interlayer bonding chemistry of the double layer PDMS device was analyzed followed by subsequent mechanical analysis. 3) The efficacy of various surface treatment techniques on hydrophobic PDMS surfaces was investigated using fluorescently tagged bacteria (E. Coli) flowed through microchannels as reporter particles to measure non-specific adhesion, which will provide useful information in minimizing channel fouling for biological applications.
by Hyesung Park.
S.M.
Spielberg, Nathan (Nathan A. ). "Maskless photopatterning of cells in microfluidic devices/". Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98762.
Texto completoCataloged from PDF version of thesis.
Includes bibliographical references (pages 91-92).
Upon examining current methods for printing and patterning of live biological cells, there is a need for a method capable of printing with the resolution of single biological cells to organize them into complex structures. In order to fill this need, building upon previous design of a dynamic lithography system, a stop flow lithography system was implemented capable of patterning individual particles with a mean accuracy of 11.92 [mu]m and a standard deviation of 4.63 [mu]m. This was achieved by improving the tracking capability of the software by measuring the exposure vs velocity relationship to anchor the particle as well as implementing a stop flow lithography based software approach. With the goal of producing 3D functionalized tissue, a 3D printing module was constructed for the dynamic lithography system that constructed microscale parts with a minimum layer height 16.42 [mu]m of and planar resolution of 10 [mu]m, comparable to the top available micro-scale 3D printers. To push the capability of the system, I analyzed and presented the limitations of the process via an opto-thermal model, and a computational fluid dynamics model which is then studied through a previously developed throughput analysis to get a theoretical maximum output of the system. In analyzing the limitations of the printing process, maximum input optical system power was characterized, and a theoretical maximum system throughput of 10,000 particles per second was calculated. This work is a step towards voxel based multimaterial printing, leading to printing of living artificial biological organs, better organs on a chip, or even bionic implants that combine electrical and biological elements.
by Nathan Spielberg.
S.B.
Sharma, Amita. "Towards a UV detector for microfluidic devices". Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15690.
Texto completoDepartment of Chemistry
Christopher T. Culbertson
Chemists have been trying to relate the structure and composition of different cereal proteins to their physical properties to better inform their product use for more than 250 years now. Among these cereals, wheat is considered the most important due to its unique ability to form viscoelastic dough and retain gas during fermentation, the latter being important for bread making. This property is due to the endosperm part of wheat that contains proteins mostly gliadins and glutens. It is known that the composition and relative ratio of these proteins is determined by both the growing environment and genetics. Manipulation of the genetics allows one for control of only about 50% of the end use quality of the wheat and the rest is controlled by environment. Currently, the bread making quality of wheat is determined by baking test loaves of bread. This process is time consuming and wasteful. The main goal of this project was to create fingerprints of gliadin proteins for different wheat cultivars as a function of environmental conditions. This would then allow wheat kernels to be analyzed and assessed right after harvest to determine their appropriateness for making the various wheat products. Researchers have tried to create a catalogue of information for individual wheat cultivars by ‘fingerprinting’ the gliadins proteins in wheat using various analytical techniques including capillary electrophoresis (CE). CE offers advantages like high separation efficiency, and faster analysis. Further miniaturization of CE on microfluidic devices has enhanced the speed and efficiency of separation. Furthermore, it is possible to integrate multiple chemical analysis processes like sample preparation, separation and detection in a single microfluidics device. Microfluidic uses micron sized separation channels defined in a glass, quartz or polymer. This dissertation is focused on fabricating multilayer microfluidic devices from Poly(dimethylsiloxane) (PDMS) and using these devices to electrophoretically separate wheat gliadin proteins followed by detection using UV absorption in less than 5 min. PDMS is cheap, easy to fabricate and is optically transparent above ~230nm. Initial results of the UV absorbance detector developed for this device are presented.
Hisey, Colin Lee Hisey. "Microfluidic Devices for Clinical Cancer Sample Characterization". The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1525783108483419.
Texto completoDam, R. Michael van Bockrath Marc William. "Solvent-resistant elastomeric microfluidic devices and applications /". Diss., Pasadena, Calif. : California Institute of Technology, 2006. http://resolver.caltech.edu/CaltechETD:etd-12052005-234258.
Texto completoPadoin, Natan. "Contributions to process intensification in microfluidic devices". reponame:Repositório Institucional da UFSC, 2016. https://repositorio.ufsc.br/xmlui/handle/123456789/175903.
Texto completoMade available in DSpace on 2017-05-23T04:23:06Z (GMT). No. of bitstreams: 1 345246.pdf: 3833045 bytes, checksum: 35d80aaf8c01e7907f32f268d7c127d3 (MD5) Previous issue date: 2016
Abstract : In this work, answers to some gaps found in the literature on the field of process intensification in microfluidic devices were proposed. The behavior of a carbon-based composite photocatalyst, specifically a composite of TiO2 and graphene, immobilized on the inner walls of a microchannel reactor, was evaluated and compared with a system containing pristine TiO2. Additionally, a comprehensive computational simulation was performed, based on fundamental physics of semiconductors and considering the coupling of radiation distribution, fluid flow, mass transport and chemical reactions. Moreover, a numerical study was carried out aiming to determine optimal photocatalytic film thicknesses for different illumination mechanisms (backside illumination, BSI, and front-side illumination, FSI) as a function of relevant operational variables and parameters, namely the incident irradiation, the apparent first-order reaction constant, the effective diffusivity and the absorption coefficient. Finally, the possibility of numerically predict the effect of wall wettability on gas-liquid flow pattern developed in microfluidic devices was investigated.
Dispositivos microfluídicos são baseados em microcanais nos quais o diâmetro efetivo é da ordem de centenas de micrômetros, resultando em elevada razão área/volume. Embora um considerável avanço tenha sido observado nessa área nas últimas décadas, resultando, inclusive, em aplicações industriais comercialmente disponíveis, ainda há importantes questões em aberto. Neste trabalho, respostas a algumas dessas questões foram propostas. Em particular, procurou-se determinar o comportamento de dispositivos microfluídicos aplicados à intensificação de processos fotocatalíticos considerando um fotocatalisador compósito (especificamente um compósito de dióxido de titânio e grafeno) imobilizado nas paredes internas. Tal sistema foi, então, comparado a um equivalente no qual dióxido de titânio puro foi imobilizado. As partículas de dióxido de titânio e do compósito de dióxido de titânio-grafeno foram depositadas por meio de um método térmico. Suspensões de TiO2 e TiO2- grafeno foram preparadas e injetadas ao longo de microcanais de chips microfluídicos comerciais construídos com vidro borossilicato. Os dispositivos foram, então, tratados termicamente para promover a evaporação do solvente (água) e a deposição do fotocatalisador nas paredes internas. O processo foi realizado ciclicamente para promover a formação de múltiplas camadas. A evolução da deposição foi avaliada pelo monitoramento dos perfis óticos dos sistemas. Azul de metileno foi usado como reagente modelo em ensaios de fotodegradação. Ensaios preliminares permitiram determinar o efeito dos fenômenos de adsorção e fotólise sobre o comportamento global. Nos experimentos de reação fotocatalisada observou-se que uma maior velocidade de reação inicial foi obtida no microrreator contendo fotocatalisador composto (TiO2-GR) imobilizado nas paredes internas, mas ambos os sistemas (TiO2 e TiO2- GR) exibiram velocidades de reação similares quando o estado estacionário foi alcançado. Verificou-se que a taxa de descolorização do azul de metileno no chip microfluídico foi, aproximadamente, uma ordem de magnitude maior que aquela reportada em sistemas macroscópicos equivalentes em condições experimentais similares. Além disso, investigou-se, neste trabalho, a possibilidade de avaliar teoricamente o comportamento de sistemas microfluídicos aplicados a processos fotocatalíticos com base na física fundamental de semicondutores, bem como a possibilidade de modelar computacionalmente os fenômenos acoplados (distribuição de intensidade luminosa, escoamento, transporte de massa e reação química) que ocorrem em reatores de microcanais (provendo uma estimativa para o desempenho do reator, dos pontos de vista global e local). O modelo computacional foi validado com os resultados experimentais. Na sequência, o modelo computacional foi aplicado para a predição da melhor espessura para o filme fotocatalítico imobilizado nas paredes internas de dispositivos microfluídicos em diferentes condições de iluminação (backside illumination, BSI, e front- side illumination, FSI) como função de variáveis operacionais e parâmetros relevantes, nomeadamente a irradiação incidente, a constante de velocidade de reação aparente de pseudo-primeira ordem, a difusividade efetiva e o coeficiente de absorção do fotocatalisador. Finalmente, a possibilidade de predizer numericamente o efeito da molhabilidade da parede sobre padrões de escoamento multifásicos desenvolvidos em microcanais foi avaliada. Tal modelo computacional pode ser utilizado como fonte de informação prévia sobre o impacto de diferentes propriedades do filme fotocatalítico na morfologia interfacial de escoamento gás-líquido em microrreatores fotoquímicos. Em particular, escoamentos gás-líquido isotérmicos (Taylor e estratificado) foram avaliados através do modelo volume of fluid (VOF). Microcanais com condições limites de hidrofilicidade e hidrofobicidade foram investigados tomando-se como base um referencial experimental disponível na literatura. Um estudo preliminar detalhado foi conduzido para a determinação da malha computacional ótima, capaz de permitir modelagem adequada do filme líquido formado entre as cavidades de gás e a parede sólida, no caso de Taylor flow. Os resultados numéricos foram comparados com dados experimentais (comprimento máximo de cavidade e área de cavidade, para o caso de Taylor flow, e espessura do filme gasoso no caso de escoamento estratificado) e algumas correlações disponíveis (comprimento máximo de cavidade e perda de carga por cavidade) e boa concordância foi observada. Nas mesmas condições de alimentação, o modelo foi capaz de captar os diferentes padrões de escoamento gás-líquido esperados quando o ângulo de contato da parede foi variado. Portanto, tal modelo computacional pode ser utilizado em estudos de scale out com o objetivo de projetar e otimizar reatores compactos modulares baseados na tecnologia de microcanais nos quais escoamento multifásico, particularmente gás e líquido, é estabelecido. Discussões acerca das limitações e de propostas futuras referentes ao desenvolvimento deste trabalho também são apresentadas.
Rossetto, Nicola. "Materials and methods for modular microfluidic devices". Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422583.
Texto completoQuesto lavoro di tesi tratta dello studio di materiali e metodi che possono essere applicati alla realizzazione di dispositivi microfluidici (DMF). In particolare l’attenzione è rivolta ai dispositivi modulari, piuttosto che a quelli altamente integrati. Le ragioni dietro questa scelta sono spiegate in dettaglio nella Sezione 1.2 di questa tesi, ma possono essere qui sintetizzate nel fatto che anche se i DMF integrati offrono grandi vantaggi in termini di dimensioni finali, i dispositivi modulari sono più versatili, e quindi particolarmente utili per applicazioni nel campo della ricerca. La prima parte del lavoro qui riportato descrive le tecniche di microfabbricazione utilizzate per la realizzazione di moduli microfluidici monofunzionali. I dispositivi sono stati realizzati per replica molding in PDMS a partire da master in SU-8. I master sono stati a loro volta fabbricati tramite litografia UV con maschera oppure per scrittura laser diretta ad uno o due fotoni, a seconda dei requisiti di risoluzione. Il replica molding è un metodo molto rapido ed efficiente per realizzare DMF, ma presenta alcuni limiti per quanto riguarda la forma delle strutture che è possibile replicare con successo. Alla luce di questo, un sol-gel fotopolimerizzabile ibrido organico/inorganico viene qui proposto e testato come materiale alternativo per la fabbricazione di DMF. I risultati della caratterizzazione rivelano che questo materiale è biocompatibile e presenta proprietà meccaniche migliori di quelle del PDMS, ma strutture con più di una dimensione eccedente i pochi micrometri tendono a sviluppare cricche, cosa che impedisce l’utilizzo di questo sol-gel come materiale massivo. Ciononostante, questo sol-gel potrebbe venir efficacemente impiegato per la realizzazione di sottostrutturazioni all’interno di canali microfluidici. Dopo questo studio sui materiali, un modulo microfluidico per il mescolamento è proposto e testato. Dato che le condizioni di flusso laminare sono dominanti all’interno dei microcanali, per ottenere un mescolamento efficiente in un DMF è necessario includere nel dispositivo un miscelatore specificatamente progettato. Il modulo proposto utilizza delle ostruzioni all’interno del microcanale per perturbare il flusso laminare e quindi favorire il mescolamento. Con l’aiuto di alcune simulazioni numeriche, le geometrie più efficienti sono state individuate, e due layout particolarmente promettenti sono stati realizzati e caratterizzati sperimentalmente misurando la diluizione di un fluoroforo (mescolamento tra una soluzione del fluoroforo e puro solvente) attraverso la microscopia confocale di fluorescenza. A seguire, viene riportata la fabbricazione e caratterizzazione di un modulo optofluidico per la deflessione della luce. Questo dispositivo utilizza un flusso segmentato acqua/aria generato da una giunzione a T per trasmettere o riflettere (per riflessione totale interna) alternativamente un fascio laser. Questa alternanza è periodica, e la sua frequenza può essere controllata variando la portata dei flussi iniettati di aria e acqua. Inoltre, il duty cycle del modulo è stato caratterizzato, e viene proposto e verificato un metodo per modularlo attraverso un aumento della temperatura dell’acqua. Infine, vengono descritti alcuni tentativi di generare un PDMS nanoporoso con basso indice di rifrazione. La messa a punto di una procedura efficiente per la fabbricazione di questo genere di materiale porterebbe alla possibilità di usare i classici canali microfluidici come guide d’onda. Al momento questi tentativi hanno avuto solo parziale successo, ma i maggiori punti di criticità sono stati identificati, e vengono proposte alcune strategie per il loro futuro superamento.
Hatch, Anson Verlin. "Diffusion based analysis of molecular binding reactions in microfluidic devices /". Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8014.
Texto completoFoley, John J. "Microfluidic Electrical Impedance Spectroscopy". DigitalCommons@CalPoly, 2018. https://digitalcommons.calpoly.edu/theses/1950.
Texto completoKong, Tiantian y 孔湉湉. "Microfluidic fabrication of polymer-based microparticles for biomedical applications". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196008.
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Mechanical Engineering
Doctoral
Doctor of Philosophy
Jang, Ling-Sheng. "Microfluidic mixing technology for biological applications /". Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/7152.
Texto completoKlasner, Scott A. "Novel capillary and microfluidic devices for biological analyses". Diss., Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3747.
Texto completoParra, Cabrera César Alejandro. "Microfluidic devices with integrated biosensors for biomedical applications". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/284758.
Texto completoEn años recientes, la comunidad de LOC ha enfocado todos sus esfuerzos en la investigación de nuevas aplicaciones para la biomedicina y biotecnología. Algunos países en vías de desarrollados no tienen tecnologías de diagnóstico adecuadas, además el suministro y almacenamiento de los reactivos es en muchos casos limitado, y en ocasiones cuentan con un acceso limitado al consumo de energía. Por otra parte, los países desarrollados se han encontrado con una población envejecida, y por lo tanto se ha generado la necesidad de contar con nuevas tecnologías para el diagnóstico de enfermedades las cuales sean accesibles y orientadas a una terapia más personalizada. Tanto la microfluídica como los LOC han permitido la integración de funciones de análisis complejas capaces de desarrollar herramientas de diagnostico más precisas, de bajo coste y confiables. Actualmente toda la atención se ha centrado en el diseño de aplicaciones para administración de fármacos 1, análisis celular 2 y diagnostico de enfermedades 3. La introducción de la microfluídica ha servido para mejorar el desarrollo de nuevos dispositivos point-of-care, pero todavía existen algunos problemas que han evitado la producción masiva de estos LOC. Las áreas en las que se pretende conseguir una mejora son la recolección de la muestra, mejora de la interfaz entre el chip y el usuario, tratamiento previo de la muestra, mejorar la estabilidad de los reactivos, trabajo con muestras complejas, detección múltiple de biomarcadores y simplificación del sistema de medida 4. Nuestros esfuerzos se han dedicado en desarrollar un sistema LOC con capacidad de detección electroquímica ajustable a cualquier biomarcador, dependiendo únicamente en la cantidad de muestra y los tiempos de análisis. Nuestros dispositivos microfluídicos cuentan con biosensores integrados de bajo coste con capacidad de auto-funcionalización. La funcionalización de los biosensores se realiza in-situ y selectivamente, antes de la detección, manteniendo el área de detección inerte hasta el inicio de la prueba. Los reactivos y el área de detección se almacenan por separado y entran en contacto hasta el inicio del experimento, lo cual facilita el método de fabricación. Se ha podido desarrollar este trabajo gracias a los estudios previos realizados en nuestro grupo en distintas disciplinas, tales como: microfluídica 5-8, funcionalización de superficies 9-14 y biosensores electroquímicos 15-19. Bibliografía 1. I. U. Khan, C. A. Serra, N. Anton and T. Vandamme, Journal of Controlled Release, 2013, 172, 1065-1074. 2. H. Andersson and A. Van den Berg, Sensors and Actuators B: Chemical, 2003, 92, 315-325. 3. M. J. Cima, Annual Review of Chemical and Biomolecular Engineering, 2011, 2, 355-378. 4. C. D. Chin, V. Linder and S. K. Sia, Lab on a Chip, 2012, 12, 2118-2134. 5. R. Rodriguez-Trujillo, C. A. Mills, J. Samitier and G. Gomila, Microfluidics and Nanofluidics, 2007, 3, 171-176. 6. R. Rodriguez-Trujillo, O. Castillo-Fernandez, M. Garrido, M. Arundell, A. Valencia and G. Gomila, Biosensors and Bioelectronics, 2008, 24, 290-296. 7. O. Castillo-Fernandez, R. Rodriguez-Trujillo, G. Gomila and J. Samitier, Microfluidics and Nanofluidics, 2014, 16, 91-99. 8. J. Comelles, V. Hortigüela, J. Samitier and E. Martínez, Langmuir, 2012, 28, 13688-13697. 9. E. Prats-Alfonso, F. García-Martín, N. Bayo, L. J. Cruz, M. Pla-Roca, J. Samitier, A. Errachid and F. Albericio, Tetrahedron, 2006, 62, 6876-6881. 10. J. Vidic, M. Pla-Roca, J. Grosclaude, M.-A. Persuy, R. Monnerie, D. Caballero, A. Errachid, Y. Hou, N. Jaffrezic-Renault, R. Salesse, E. Pajot-Augy and J. Samitier, Analytical Chemistry, 2007, 79, 3280-3290. 11. Y. Hou, S. Helali, A. Zhang, N. Jaffrezic-Renault, C. Martelet, J. Minic, T. Gorojankina, M.-A. Persuy, E. Pajot-Augy, R. Salesse, F. Bessueille, J. Samitier, A. Errachid, V. Akimov, L. Reggiani, C. Pennetta and E. Alfinito, Biosensors and Bioelectronics, 2006, 21, 1393-1402. 12. S. Rodríguez Seguí, M. Pla, J. Minic, E. Pajot‐Augy, R. Salesse, Y. Hou, N. Jaffrezic‐Renault, C. A. Mills, J. Samitier and A. Errachid, Analytical Letters, 2006, 39, 1735-1745. 13. A. Lagunas, J. Comelles, E. Martínez and J. Samitier, Langmuir, 2010, 26, 14154-14161. 14. A. Lagunas, J. Comelles, S. Oberhansl, V. Hortigüela, E. Martínez and J. Samitier, Nanomedicine: Nanotechnology, Biology and Medicine, 2013, 9, 694-701. 15. M. Castellarnau, N. Zine, J. Bausells, C. Madrid, A. Juárez, J. Samitier and A. Errachid, Materials Science and Engineering: C, 2008, 28, 680-685. 16. M. Castellarnau, N. Zine, J. Bausells, C. Madrid, A. Juárez, J. Samitier and A. Errachid, Sensors and Actuators B: Chemical, 2007, 120, 615-620. 17. M. Kuphal, C. A. Mills, H. Korri-Youssoufi and J. Samitier, Sensors and Actuators B: Chemical, 2012, 161, 279-284. 18. D. Caballero, E. Martinez, J. Bausells, A. Errachid and J. Samitier, Analytica Chimica Acta, 2012, 720, 43-48. 19. M. Barreiros dos Santos, J. P. Agusil, B. Prieto-Simón, C. Sporer, V. Teixeira and J. Samitier, Biosensors and Bioelectronics, 2013, 45, 174-180.
Jiang, Guifeng. "Developing microfluidic devices for genetic and biochemical analyses". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60304.pdf.
Texto completoAndersson, Helene. "Microfluidic devices for biotechnology and organic chemical applications". Doctoral thesis, Stockholm, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3248.
Texto completoNikcevic, Irena. "Development of techniques and materials for microfluidic devices". Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1212155007.
Texto completoAuroux, Pierre-Alain. "Microfluidic devices used for shunting polymerase chain reactions". Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416943.
Texto completoAtkins, Nigel Philip. "Microfluidic PCR devices with electrochemical detection of DNA". Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/4880/.
Texto completoNIKCEVIC, IRENA. "Development of techniques and materials for microfluidic devices". University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212155007.
Texto completoOlabanji, Olumuyiwa. "The study and characterisation of plasma microfluidic devices". Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/6533/.
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