Literatura académica sobre el tema "Métabolisme des xénobiotiques/odorants"
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Artículos de revistas sobre el tema "Métabolisme des xénobiotiques/odorants"
Mansuy, Daniel. "Le métabolisme des xénobiotiques : effets bénéfiques, effets néfastes". Biologie Aujourd'hui 207, n.º 1 (2013): 33–37. http://dx.doi.org/10.1051/jbio/2013003.
Texto completoLe Daré, Brendan, Pierre-Jean Ferron y Thomas Gicquel. "Il était une fois l’hépatotoxicité…". médecine/sciences 37, n.º 3 (marzo de 2021): 235–41. http://dx.doi.org/10.1051/medsci/2021009.
Texto completoGicquel, Thomas, Romain Pelletier, Brendan Le Daré, Thomas Kerforne, Angéline Kernalleguen, Isabelle Morel, Anne Corlu y Michel Rayar. "Étude du métabolisme hépatique des xénobiotiques à l’aide d’un modèle de foie porcin perfusé ex vivo : exemple du tramadol". Toxicologie Analytique et Clinique 36, n.º 2 (junio de 2024): S50—S51. http://dx.doi.org/10.1016/j.toxac.2024.03.076.
Texto completoLecompte, Yannick, Camille Richeval, Luc Humbert, Martine Perrin y Patrick Arpino. "Étude du métabolisme de xénobiotiques inconnus par spectrométrie de masse hybride « quadripôle-temps de vol » : à propos de la méthoxyisoflavone". Toxicologie Analytique et Clinique 26, n.º 2 (junio de 2014): 51–60. http://dx.doi.org/10.1016/j.toxac.2014.04.001.
Texto completoCabaret, O., O. Puel, F. Botterel, M. Pean, M. Delaforge y S. Bretagne. "Rôle des enzymes du métabolisme des xénobiotiques dans la toxicité pulmonaire de deux mycotoxines d ’Aspergillus versicolor et d’ Aspergillus nidulans". Journal de Mycologie Médicale 22, n.º 3 (septiembre de 2012): 275. http://dx.doi.org/10.1016/j.mycmed.2012.07.014.
Texto completoAninat, C., A. Piton, D. Glaise, T. Le Charpentier, S. Langouët, F. Morel, C. Guguen-Guillouzo y A. Guillouzo. "CA50 - Expression d’enzymes de phase 1 et de phase 2 du métabolisme des xénobiotiques dans les cellules heparg dérivées d’un carcinome hépatocellulaire humain". Gastroentérologie Clinique et Biologique 29, n.º 8-9 (agosto de 2005): 924. http://dx.doi.org/10.1016/s0399-8320(05)86447-4.
Texto completoCHILLIARD, Y., J. J. COLLEAU, C. DISENHAUS, C. LERONDELLE, C. MOUCHET y A. PARIS. "L’hormone de croissance recombinante : intérêt et risques potentiels de son utilisation pour la production laitière bovine". INRAE Productions Animales 11, n.º 1 (2 de febrero de 1998): 15–32. http://dx.doi.org/10.20870/productions-animales.1998.11.1.3913.
Texto completoTesis sobre el tema "Métabolisme des xénobiotiques/odorants"
Mérignac-Lacombe, Jeanne. "Approches innovantes dans la caractérisation des enzymes du métabolisme des xénobiotiques dans les muqueuses nasales : du modèle animal à l’ingénierie tissulaire". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCI003.
Texto completoOur sensitive olfaction relies on Xenobiotic Metabolizing Enzymes (XMEs) that protect the nasal tissue from potentially harmful volatile compounds, but also quickly terminate the olfactory signal to prepare olfactory receptors to detect new odorant stimuli. Some of them also generate metabolites that participate in the odorant signal, hence their other name Odorant Metabolizing Enzymes (OMEs). The objective of this thesis was to study the nasal XMEs using two innovative models that aim to comply as much as possible with the 3R principles (Replacement, Reduction, and Refinement of animal experiments). While rat olfactory explants showed some limitations in investigating XME gene expression, human nasal respiratory mucosa tissue models were promising in vitro tools for the odorant metabolism field. These models express around 80 XME isoforms and efflux transporters. Selected XME genes were not regulated by the compounds chosen for the thesis, however, they were able to metabolize odorants, such as benzaldehyde and 3,4-hexanedione. Overall, protocols were created and adapted to use tissue models to study the implication of the respiratory epithelium in odorant metabolism in humans. This work provides novel knowledge on the involvement of the human respiratory tissue in odorant metabolism and contributes to the reduction of animal experiments
Minn, Anne-Laure. "Caractérisation des enzymes et des transporteurs impliqués dans le métabolisme des xénobiotiques dans les tissus olfactifs". Dijon, 2005. http://www.theses.fr/2005DIJOPE01.
Texto completoRobert-Hazotte, Aline. "Impact du métabolisme des molécules odorantes sur la perception olfactive chez l'Homme". Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCK073.
Texto completoThe sense of smell permits the perception of volatile substances commonly known as odors. This sense plays an important role in the feeding and wellness of individuals because it involves exchanges with their environment (search for food or partners, predators detection…). The efficiency of the olfactory system mainly relies on its sensitivity depending on the odorant affinity for their olfactory receptors but also on an enzymatic clearance mechanism of odorants which involves the Odorant metabolizing Enzymes (OME) to avoid the saturation of the receptors. Recent studies have shown that the biotransformation of odorants by EMO, in the olfactory epithelium, participates in the olfactory perception. Indeed, OME catalyse the deactivation of the odorants and their subsequent elimination which led to the termination of the olfactory signal. In this context, this work aims to provide a better understanding of the enzymatic mechanisms of the OME in mammal olfactory perception and to study more specifically these mechanisms in human.The first axis of this work, based on physicochemical analysis, has consisted to develop an innovative proton transfer reaction mass spectrometry technique (PTR-MS) to allow the analysis in real time of the odorants biotransformation by OME. This technique was first applied ex vivo using rats and rabbits olfactory epithelium and olfactory mucus but also in vivo directly inside the human nasal cavity. Thus, we have demonstrated that the olfactory biotransformation of odorants catalyzed by different enzymes like glutathione transferases, carboxylesterases and dicarbonyl xylulose reductases (DCXR), is a very fast mechanism (few milliseconds). This very high velocity is perfectly consistent with the physiological dynamics of the olfactory process. Moreover, PTR-MS analyzes revealed that the odorants biotransformation could produce volatile metabolites with odorous properties which could participate in the global olfactory perception by interacting also with olfactory receptors. These various metabolites have been formally identified by a gas chromatography-mass spectrometry technique (GC-MS).The second axis, based on psychophysical method, evaluated the impact of the odorant metabolism in the human olfactory perception. For this purpose, an original approach recently developed in the lab, consisting of the modulation of the olfactory perception through a competition between odorants metabolized by the same EMO was transposed from the rabbit model to the human. The metabolic competition between several diketones toward DCXR was first demonstrated by biochemical analysis using the corresponding human recombinant enzyme. Then, an olfactometric study carried out on a 40 subjects panel demonstrated that this competition mechanism between odorants induces modulations of the biotransformation of these molecules and thus leads to modifications of their relative bioavailability and in fine of their perception. These new and significant results demonstrate that modulations impacting odorants metabolism leads immediately to changes in their olfactory perception. This thesis highlights on the function of EMO in mammals and reveals for the first time in human a significant role of the odorant metabolism in olfactory perception
Thiebaud, Nicolas. "Caractérisation des enzymes du métabolisme des xénobiotiques olfactives chez le rat : régulation et rôle dans la détection périphérique des molécules odorantes". Thesis, Dijon, 2010. http://www.theses.fr/2010DIJOS024.
Texto completoXenobiotic metabolizing enzymes (XMEs) play a central role in the biotransformation and the elimination of foreign compounds reaching the body. Organized as a biotransformation network, these enzymes catalyze various reactions (oxidations, conjugations …) in order to increase the water solubility of compounds. XMEs are highly expressed in the mammalian olfactory epithelium and in vitro studies showed that they have important activities. Besides a role in the metabolism of toxic compounds, a role in the peripheral regulation of the olfactory process has been hypothesized. XMEs could contribute to maintain the sensibility of the olfactory system, by eliminating or inactivating odorant molecules present in the perireceptor space. However, scientific proofs of such a role are still limited. In a first study, we demonstrated that olfactory XMEs can be modulated by chemical treatments identified to induce the enzyme expression in the liver (dexamethasone, Aroclor …). The intensities of the effects were lower in the OM than in the liver. Dexamethasone, a synthetic glucocorticoid, was found to increase significantly the expression of several enzymes and transporters in the olfactory mucosa. This study suggests that the expression of olfactory XME is controlled by tissue-specific mechanisms. In the second part, the metabolism of some odorant molecules was studied in vitro. We observed that the olfactory mucosa of rats possesses a high metabolic capacity and catalyses the formation of hydroxylated metabolites. Finally, the consequences of this metabolism were evaluated by recording electro-olfactograms (EOG) from the olfactory mucosa of rats. We showed that, at same concentrations, amplitudes of EOG signals generated by the metabolites were lower than those elicited by the parent molecules. Moreover, the perfusion of the mucosa with specific inhibitors of cytochromes P450 or carboxylesterases induced a significant modification of EOG signals. These studies demonstrate that the biotransformation of odorant molecules have an impact on the olfactory signal. Taken together, these studies support the hypothesis that XME are involved in the first stage of the olfactory perception. These enzymes could catalyze the biotransformation of odorant molecules in order to avoid the saturation of the olfactory system
Schoumacker, Rachel. "Perception du gras : variabilité interindividuelle et origine". Thesis, Dijon, 2016. http://www.theses.fr/2016DIJOS030/document.
Texto completoTo reduce the fat content in food products as recommended by the National Nutrition and Health Plan, it is necessary to understand the fat perception mechanisms. In this context, this thesis work aimed to contribute to the understanding of fat perception through the study of interindividual variability in fat perception and the research of its origin.For this purpose, a multidisciplinary approach combining physico-chemistry of “fatty” aroma molecules, subjects’ oral physiology, food oral processing and sensory perception during food consumption has been established. A particular focus has been done on the olfactory component of fat perception, especially on the potential contribution of the metabolites produced in the human nasal cavity from odorous volatile compounds.This work shows that reducing fat content in cottage cheese decreases the perception of the cream aroma, increases bitterness and astringency and decreases the perceived greasy film. The results confirmed the multidimensional nature of fat perception. This work also shows that fat perception is related to the lipid content of the mouth coating as well as the aroma compounds composition of the food matrix.It highlights three groups of subjects with significant difference in fat sensitivity. These groups also differ in several physiological and anatomical parameters which can impact tactile, taste and smell sensations and therefore potentially fat perception. Finally, this work proves the existence in the human olfactory mucosa of enzymes capable of metabolizing odorous compounds into volatile metabolites. These metabolites proved to be themselves odorants could be involved in fat perception or its modulation
Souhaili-El, Amri Hajar. "Albendazole : métabolisme et régulation des enzymes hépatiques du métabolisme des xénobiotiques". Nancy 1, 1988. http://www.theses.fr/1988NAN10122.
Texto completoLakehal, Fatima. "Métabolisme et toxicité des xénobiotiques dans l'épithélium biliaire". Paris 5, 2000. http://www.theses.fr/2000PA05N021.
Texto completoLe, Daré Brendan. "Xénobiotiques hépatotoxiques : études de métabolisme et mécanismes d’action". Thesis, Rennes 1, 2021. http://www.theses.fr/2021REN1B005.
Texto completoXenobiotic-induced hepatotoxicity is an extremely rich subject, given the multiple mechanisms and actors involved. This translational work aims to improve ethanol and amanitins (powerful fungal toxins) hepatotoxic mechanisms understanding, in order to provide new elements to optimize the therapeutic management of intoxicated patients. In a first step, we provide additional elements of understanding on macrophages response mechanisms to ethanol. These xenobiotic-cell interactions, shown through the P2X7 receptor induction example, seem to contribute in alcoholic liver damage severity, and testify to the macrophages plasticity in pathological situations. These results suggest in particular the interest of P2X7 receptor antagonist’s development in the treatment of alcoholism. In a second step, we are applied molecular networking, which allows the visualization of complex data acquired by LC-MS/MS, to xenobiotic metabolism study. The acebutolol metabolism example, in the context of voluntary drug intoxication on the one hand, and the in vitro quetiapine metabolism study on the other hand, have provided consistent evidence concerning molecular network interest in this context. In a third and final step, the molecular network application allowed us to rule out the hypothesis of an in vivo and in vitro amanitins metabolism. Moreover, our results show that the hepatocyte-like cellular model of differentiated HepaRG is a relevant model in amanitins study, and show the mitochondrial ROS production implication in these substances toxicity
Chraibi-Ben, Moubarik Soumaya. "Contribution à l'étude de l'influence de chaines ramifiées courtes sur le métabolisme des xenobiotiques". Rouen, 1999. http://www.theses.fr/1999ROUEM007.
Texto completoRésume en anglais
Waziers, Isabelle de. "Le Métabolisme intestinal des xénobiotiques et la cancérogénèse colorectale". Paris 5, 1994. http://www.theses.fr/1993PA05P602.
Texto completoLibros sobre el tema "Métabolisme des xénobiotiques/odorants"
Baselt, Randall C. Disposition of toxic drugs and chemicals in man. 6a ed. Foster City, Calif: Biomedical Publications, 2002.
Buscar texto completoAlbert, Adrien. Xenobiosis: Foods, drugs and poisons in the human body. London: Chapman and Hall, 1987.
Buscar texto completoBaselt, Randall C. Disposition of toxic drugs and chemicals in man. 5a ed. Foster City, Calif: Chemical Toxicology Institute, 2000.
Buscar texto completoColeman, Michael. Human Drug Metabolism. New York: John Wiley & Sons, Ltd., 2006.
Buscar texto completoN, Kotsonis Frank, Mackey Maureen A. 1955- y Hjelle Jerry J, eds. Nutritional toxicology. New York: Raven Press, 1994.
Buscar texto completoEmel, Arinç, Schenkman John B, Hodgson Ernest 1932- y NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 : Kus̜adası, Turkey), eds. Molecular aspects of oxidative drug metabolizing enzymes: Their significance in environmental toxicology, chemical carcinogenesis, and health. Berlin: Springer-Verlag, 1995.
Buscar texto completoBaselt, Randall C. Disposition of Toxic Drugs and Chemicals in Man. Biomedical Pubns, 2008.
Buscar texto completoBaselt, Randall C. Disposition of Toxic Drugs & Chemicals in Man. 7a ed. Biomedical Publications, 2004.
Buscar texto completoConnell, Des W. Bioaccumulation of Xenobiotic Compounds. Taylor & Francis Group, 2018.
Buscar texto completoConnell, Des W. Bioaccumulation of Xenobiotic Compounds. Taylor & Francis Group, 2017.
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