Tesis sobre el tema "Métabolisme de la proline"
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Le, Dinh Thien. "Métabolisme de la proline chez les mammifères". Paris 5, 1988. http://www.theses.fr/1988PA05P216.
Texto completoOlivares, Orianne. "Etude de la reprogrammation métabolique de l' adénocarcinome canalaire pancréatique". Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4000.
Texto completoPancreatic ductal adenocarcinoma (PDAC) has a compact architecture wherein the tumor cells are organized in glands and trapped in a fibrotic shield (stroma) made of up to 50% of collagen. This shield prevents blood supply, limits nutrients and oxygen intake. Many cells die, but some survive, and proliferate particularly by reprogramming their metabolism. The most studied metabolic reprogramming remains tumor cells addiction to glucose and the constitutive use of glycolysis, regardless of the presence of oxygen (Warburg effect). We show that the hypoxic population of PDAC also depends on glutamine degradation, and the concomitant activity of both glycolysis and glutaminolysis reactivates the hexosamine biosynthetic pathway. These compounds contribute to tumor proliferation by stabilizing glucose transporters, or oncogenes. The intense glycolytic activity of hypoxic cells allows the synthesis of lactate. Excreted in the microenvironment, it serves as a nutritive resource to oxygenic cells adjacent to the hypoxic population and enables their proliferation. We show that some oxygenated cells are also able to survive under nutrient stress by degrading collagen (ecophagy) and use proline it contains. Tumor cells intake and degrade collagen fragments to survive. Isotopic tracer experiments using labeled collagen support the idea that proline comes from the extracellular collagen. This proline is degraded and converted into glutamate, fueling the Krebs cycle for anaplerosis and promotes tumor survival. These studies therefore show the importance to study the metabolic reprogramming of PDAC, and the role of hypoxia or collagen matrix in tumor progression
Dourmap, Corentin. "Étude des interactions entre le catabolisme de la proline et le métabolisme de l'azote dans le développement de la graine chez Arabidopsis thaliana". Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS312.pdf.
Texto completoProline is a proteinogenic amino acid with numerous functions in plants especially in stress adaptations and development. Its metabolism is now well described but some of its physiological roles remained enigmatic. Synthesized in the cytosol from glutamate, proline is catabolized in the mitochondrion by the sequential action of two enzymes: proline dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH). Preliminary experiments showed weak germination rates for p5cdh mutants and weak nitrogen remobilization rate during senescence. The objectives of this thesis were to charaterize this remobilization defect and its impact on seed development. We have shown that p5cdh mutant presented a remobilization defect for nitrogen and carbon, especially when plants were grown under non limiting concentration of nitrates. Seeds produced by this mutant are out of shape and lighter. Imagery analysis have shown that embryo development of p5cdh mutant is blocked at the transition between embryogenesis and maturation phase when it is grown under high concentrations of nitrates. Embryo is blocked in its develoment in torpedo stage et is surrounded by endosperm. During the dehydration phase, embryo dies. In order to identify the role of P5CDH in seed development, developmental, metabolomics and proteomics studies were performed on maturing and dehydrating seeds. These studies have shown that during seed development, the first sign of disturbance in p5cdh mutant is visible at the beginning of the maturation phase with a weak and shorter greening phase compared to the wild-type. It is followed by a limited lipids accumulation and storage proteins. But an important accumulation of free proline were measured. These studies have also revealed an accumulation of free amino acids in p5cdh mutant's seeds and a marked disturbance of carbon metabolism. Numerous markers of anaerobic energy metabolism are induced probably linked to the loss of photosynthetic capacities of the embryo. The lower content in HSP and LEA proteins and in non-reducting sugars in p5cdh mutant reinforce the idea that the seed is not prepared to be dehydrated. Since the processes of maturation and dehydration are strongly energy demanding processes, the arrest of seed development in p5cdh mutant could be linked to a lack of energy. This lack of energy seems affect also the development of the male gametophyte since 50% of p5cdh pollen grain die during its maturation. This study shows that proline catabolism is essential to seed and pollen development, especially after the embryogenesis by provinding reduced power and ATP. It confirms the numerous hypothesis about the importance of proline and its catabolism in energy production during growth recovery after a stress but also in fast growth organs like pollen tube, root tip or cancer cells in animal models
Demange, Luc. "Etude de l'isomérisation cis-trans de la liaison aminoacyl-proline : conception de nouveaux inhibiteurs de la cyclophiline hCyp-18". Paris 11, 2001. http://www.theses.fr/2001PA112318.
Texto completoThe study reported in this manuscript was carried out in the "Département d'Ingénierie et d'Etudes des Protéines" (DIEP) of the CEA/Saclay. This work deals with a study of an enzyme catalytic mechanism and with the development of new transition-state based inhibitors : the subject was at the interface of chemistry and biology. We choosed to study the cytosolic and ubiquitous human cyclophilin hCyp-18. This enzyme catalyses the cis-trans interconversion of the aminoacyl-proline peptide bond, one of the very slow and rate-limiting steps of protein folding ; hCyp-18 is involved in many cellular functions. This enzyme is implicated in one of the numerous way of immunosuppression, and it plays a critical role during infection by HIV-1 viruses. Therefore, hCyp-18 is an interesting new therapeutic target to fight AIDS. This work began with a study of the molecular interactions between hCyp-18 and its substrates. Using small modified peptides, we found that the active site of this enzyme is divided in two functionnaly independent subsites. .
El, Moukhtari Ahmed. "Étude de l’effet d’apports exogènes de silicium et / ou de proline dans l’amélioration de la tolérance de la symbiose Medicago - Ensifer meliloti aux contraintes salines". Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS234.pdf.
Texto completoThe effects of silicon (Si) and/or proline on the tolerance to salt stress were investigated in alfalfa Medicago sativa L. and Medicago truncatula Gaertn. Two Moroccan M. sativa varieties, Oued Lmalah (OL) and Demnate 201 (Dm), and a European M. sativa variety NS Mediana ZMS V (NS Med) originating from Serbia were used. Experiments were carried out at different stages of development. Results showed that salt stress reduced seed germination and embryo viability and inhibited reserve mobilization, particularly in the NS Med variety. The restricted germination is concomitant with an oxidative stress reflected by high levels of malonyldialdehyde (MDA) and hydrogen peroxide (H2O2) and ionic toxicity indicated by lower K+/Na+ ratio. However, Si supply induces a significant accumulation of proline and improves seed germination, embryo viability and reserve mobilization. Si also triggers high catalase (CAT) and superoxide dismutase (SOD) activities and reduces MDA and H2O2 contents. During plant growth, salinity reduces plant growth and nodulation in all of the varieties. Growth restriction is accompanied by a significant decrease in leaf chlorophyll content, chlorophyll fluorescence (Fv/Fm) and stomatal conductance. Salinity also reduces plant nitrogen and K+ and increases Na+. Among the three alfalfa varieties, the European variety NS Med is the most affected. Exogenous supply of Si and proline results in a considerable accumulation of some compatible solutes, such as proline, glycine betaine and soluble sugars together with an enhanced antioxidant enzyme activity, such as SOD, CAT, ascorbate peroxidase and glutathione reductase. This improved leaf relative water content, reduced oxidative stress and therefore restores growth and photosynthetic activity of salt-stressed plants. Similarly, using the model legume M. truncatula, the application of proline and Si modulates the expression of genes encoding enzymes of proline metabolism, such as Pyroline-5-carboxylate synthetase 1 (P5CS1), P5CS2, Ornithine aminotransferase, Proline dehydrogenase 1, and P5C dehydrogenase as well as Low silicon 2 gene encoding a silicon transporter. In conclusion, separate application of proline and Si is more beneficial for improving M. sativa salt tolerance while the combined application of the two molecules is beneficial for M. truncatula
Ben, Rejeb Kilani. "Implication des espèces réactives de l'oxygène (ero) dans la régulation de la capacité antioxydante et du métabolisme de la proline chez Arabidopsis Thaliana sous contraintes hydriques". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066307/document.
Texto completoCharacterization of salt stress response in A. thaliana p5cs1-4 mutant defective in proline biosynthesis showed that no significant difference was observed in the leaf water status and Na+/K+ ratio between salt-treated WT and p5cs1-4 seedlings, suggesting that the salt hypersensitivity of the mutant was not due to the disruption of water uptake or Na+/K+ homeostasis. Foliar application of proline under salt stress increased the antioxidant activity in the p5cs1-4 mutant and restored its photosynthetic activity. The analysis of the relationship between the early production of H2O2 by the NADPH oxidase and the antioxidant defense in A. thaliana subjected to salinity showed that short-term salt exposure led to a transient and significant increase of H2O2 concentration, followed by a marked increase in Catalase, Ascorbate peroxidase and Glutathion reductase activities, pre-treatment with either dimethylthiourea, a chemical trap for H2O2, or two NADPH oxidase inhibitors such as imidazol and diphenylene iodonium, significantly decreased the above-mentioned enzyme activities under salinity. atrbohd/f double mutant plants failed to induce the antioxidant response under the culture conditions. The better performance of the WT was related to the plant ability to deal with the salt-induced oxidative stress as compared to atrbohd/f. In addition NaCl or mannitol stress resulted in a transient increase in H2O2 content followed by an accumulation of proline upon stress. In contrast DMTU and DPI were found to significantly inhibit proline accumulation. Expression level of the key enzyme involved in the biosynthesis of proline was observed to be diminished by DPI and in atrboh mutants
Thiery, Laurent. "Etude de la régulation du métabolisme de la proline au cours d'un stress hyperosmotique chez Arabidopsis thaliana : rôle du calcium et des phospholipases D". Paris 6, 2003. http://www.theses.fr/2003PA066320.
Texto completoParre, Elodie. "La signalisation lipidique et le métabolisme de la proline en réponse à des contraintes hydriques : rôles des phospholipases C et D chez Arabidopsis thaliana". Paris 6, 2008. http://www.theses.fr/2008PA066213.
Texto completoZheng, Yao. "Identification of interacting mitochondrial enzymes involved in pyrroline-5-carboxylate metabolism in Arabidopsis thaliana". Electronic Thesis or Diss., Sorbonne université, 2021. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2021SORUS269.pdf.
Texto completoThe proteinogenic amino acid proline plays a crucial role for cellular metabolism in living organisms. In mitochondria, proline is oxidized to glutamate by the sequential action of proline dehydrogenase (ProDH) and pyrroline-5-carboxylate (P5C) dehydrogenase (P5CDH). In addition, ornithine δ-aminotransferase (δOAT) also participates in P5C formation through the conversion of ornithine and α-ketoglutarate into glutamate and P5C. Using mutants and biochemical approaches, ProDH1, P5CDH and δOAT were shown to be involved during dark-induced leaf senescence (DIS) in Arabidopsis thaliana. Striking accumulation of P5C and proline was observed in p5cdh mutant and to a lesser extent in prodh1prodh2 mutant, suggesting a putative proline-P5C cycle. Metabolomic analysis indicated that prodh1prodh2 and p5cdh have a similar metabolomic profile, but significantly different from wild-type and oat mutant, demonstrating the role of proline oxidation during DIS. ProDH1 was shown to be preferentially associated to the mitochondrial membrane fraction, while P5CDH and δOAT are more evenly distributed between matrix and membrane fractions. Homo- and hetero-oligomerizations of ProDH1, P5CDH, and δOAT were revealed using Bimolecular Fluorescence Complementation (BiFC) assay of infiltrated tobacco leaves. Interactions between P5C metabolism enzymes were further highlighted in DIS leaves using proteomics approaches coupled with mass spectrometry. Our work demonstrates that these three enzymes form P5C metabolic complex(es) involved in the oxidation of proline to fuel mitochondrial electron transfer chain to support the energy needs of senescent cells
Gouirand, Victoire. "Etude de la reprogrammation des voies métaboliques des acides aminés au cours de la carcinogenèse pancréatique". Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0673.
Texto completoThe malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, depriving tumor cells from oxygen and nutrients, which forces tumor cells to adapt their metabolism to proliferate. The thesis purpose is to define the metabolic changes related to ADKP. Using a transcriptomic analysis of PDAC from mice model, we established the PDAC metabolic profile. Focusing on amino acid metabolic pathways, we identified the metabolic pathways of proline and the branched-chain amino acid, especially the leucine catabolism, as the most deregulated in ADKP compared to the normal pancreas. We demonstrated that tumor cells take up collagen-derived fibroblasts, thanks macropinocytosis, when they are nutrient deprived. Once collagen is internalized, its subsequent digestion supplies TCA with proline. Also, inhibition of proline degradation leads to a decrease in tumor proliferation in vitro and in vivo. We have shown leucine catabolism is specific to tumor cells and the final degradation products: the β-hydroxybutyrate (βOHB) appears as a key element of this metabolism. To produce βOHB, tumor cells use HMGCL, a crucial enzyme involved in leucine degradation. In our work we demonstrated that HMGCL suppression in PDAC cells decreases their oncogenic and metastatic capacities in vitro and in vivo. In addition, we have demonstrated in vivo that βOHB increases tumor growth and metastasis formation. Thus, our works show 1/ the metabolic plasticity of cells, 2/the influence of microenvironment on tumor cell metabolism, 3/ the importance to study tumor metabolism for the finding of new therapeutic targets
Thivolle-Cazat, Alain. "Dynamique de l'azote dans les jeunes plants d'épicea commun (Picea Abies (L. ) Karsten)". Nancy 1, 1992. http://docnum.univ-lorraine.fr/public/SCD_T_1992_0014_THIVOLLE_CAZAT.pdf.
Texto completoBen, Rejeb Kilani. "Implication des espèces réactives de l'oxygène (ero) dans la régulation de la capacité antioxydante et du métabolisme de la proline chez Arabidopsis Thaliana sous contraintes hydriques". Electronic Thesis or Diss., Paris 6, 2015. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2015PA066307.pdf.
Texto completoCharacterization of salt stress response in A. thaliana p5cs1-4 mutant defective in proline biosynthesis showed that no significant difference was observed in the leaf water status and Na+/K+ ratio between salt-treated WT and p5cs1-4 seedlings, suggesting that the salt hypersensitivity of the mutant was not due to the disruption of water uptake or Na+/K+ homeostasis. Foliar application of proline under salt stress increased the antioxidant activity in the p5cs1-4 mutant and restored its photosynthetic activity. The analysis of the relationship between the early production of H2O2 by the NADPH oxidase and the antioxidant defense in A. thaliana subjected to salinity showed that short-term salt exposure led to a transient and significant increase of H2O2 concentration, followed by a marked increase in Catalase, Ascorbate peroxidase and Glutathion reductase activities, pre-treatment with either dimethylthiourea, a chemical trap for H2O2, or two NADPH oxidase inhibitors such as imidazol and diphenylene iodonium, significantly decreased the above-mentioned enzyme activities under salinity. atrbohd/f double mutant plants failed to induce the antioxidant response under the culture conditions. The better performance of the WT was related to the plant ability to deal with the salt-induced oxidative stress as compared to atrbohd/f. In addition NaCl or mannitol stress resulted in a transient increase in H2O2 content followed by an accumulation of proline upon stress. In contrast DMTU and DPI were found to significantly inhibit proline accumulation. Expression level of the key enzyme involved in the biosynthesis of proline was observed to be diminished by DPI and in atrboh mutants
Paulhe, Frédérique. "Régulation différentielle du métabolisme des phosphoinositides par les intégrines αvβ3 et αvβ5 lors de la migration des cellules musculaires lisses". Paris 7, 2002. http://www.theses.fr/2002PA077140.
Texto completoGhars, Mohamed Ali. "Étude de la variabilité physiologique de la réponse au sel et caractérisation de voies de signalisation impliquées dans la régulation du métabolisme de la proline en réponse à des contraintes hydriques chez Thellungiella halophila et Arabidopsis thaliana". Paris 6, 2008. http://www.theses.fr/2008PA066157.
Texto completoHsueh, Li-Ching. "Studies on proline hydroxylases". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365805.
Texto completoKüllchen, Felix B. "Studies on proline 3-hydroxylase". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269221.
Texto completoSchulz, Daniel [Verfasser]. "L-Proline and Glutamatergic Neurotransmission : Clarifying the Modulatory Role of Neuronal L-Proline Transporter / Daniel Schulz". Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044971096/34.
Texto completoLawrence, Christopher C. "Studies on bacterial proline 4-hydroxylase". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358610.
Texto completoHu, Chien-an Andy. "Osmoregulation and proline biosynthesis in plants /". The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487843688956923.
Texto completoTownsend, David E. Wilkinson Brian J. "Proline transport and biosynthesis in Staphylococcus aureus". Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9311291.
Texto completoTitle from title page screen, viewed February 6, 2006. Dissertation Committee: Brian J. Wilkinson (chair), Radheshyam Jayaswal, Herman E. Brockman, Robert L. Preston, Philip D. Morse. Includes bibliographical references (leaves 107-112) and abstract. Also available in print.
Habibi-Najafi, Mohammad B. (Mohammad Bagher). "Proline-specific peptidases from Lactobacillus casei subspecies". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28455.
Texto completoStorage stability of x-prolyl dipeptidyl peptidase and proline iminopeptidase in crude extract, with and without stabilizers showed no significant loss in activity of these two enzymes at 4$ sp circ$C for 9 days without adding any stabilizers. The levels of x-prolyl dipeptidyl peptidase, proline iminopeptidase, and post proline endopeptidase activities of cells grown in whey did not vary markedly from cells grown in MRS broth. X-prolyl dipeptidyl peptidase and proline iminopeptidase were purified from crude cell-free extract of Lactobacillus casei ssp. casei LLG by Fast Protein Liquid Chromatography (FPLC) equipped with ion-exchange and gel-filtration columns. X-prolyl dipeptidyl peptidase was found to be a serine-dependent enzyme with molecular mass of 79 kDa. The pH and the temperature optima by the purified enzyme were 7.0 and 50$ sp circ$C, respectively. Proline iminopeptidase was sulfhydryl enzyme with molecular mass of 46 kDa. The maximum enzyme activity was observed at pH 7.5 and 40$ sp circ$C. This is the first report describing the purification and characterization of x-prolyl dipeptidyl peptidase and proline iminopeptidase from Lactobacillus casei to homogeneity.
The debittering of tryptic digests from $ beta$-casein by x-prolyl dipeptidyl peptidase was studied by reversed phase high performance liquid chromatography (RP-HPLC) and liquid chromatography/mass spectrometry. The results showed that two bitter peptides (f53-97 and f03-209) containing X-Pro-Y-Pro in their amino acid residues were completely hydrolyzed and many other peptides with high hydrophobicity were decreased in peak area. The addition of purified x-prolyl dipeptidyl peptidase on bitter enzyme-modified cheese (EMC) also showed that at least one bitter peptide with X-Pro-Y derived from $ alpha$-casein hydrolysis was removed.
Walters, Nicola Jane. "Arginine and proline catabolism in Schizosaccharomyces pombe". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257192.
Texto completoRobinson, Kenneth J. "Bio-organic studies on proline 4-hydroxylase". Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320660.
Texto completoJones, Iwan Gwynedd. "Desymmetrization of meso-anhydrides by proline esters". Thesis, Bangor University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265515.
Texto completoDaly, D. J. "Post-proline cleaving enzymes in skeletal muscle". Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304040.
Texto completoD'Rozario, Robert S. G. "Conformational dynamics of proline-containing transmembrane helices". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670181.
Texto completoPike, Claire Victoria Sarah. "The proline isomerase FKBP25 as a chromatin modifier". Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/252175.
Texto completoVerbruggen, Nathalie. "Proline accumulation after salt-stress in arabidopsis thaliana". Doctoral thesis, Universite Libre de Bruxelles, 1992. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212895.
Texto completoDikic, Inga. "Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5316-3/.
Texto completoNorris, Simon Richard. "Studies towards the synthesis of useful proline derivatives". Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315897.
Texto completoBess, Kirstin. "Transcriptional repression by the proline rich homeodomain protein". Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390994.
Texto completoOmar, Muhiadin. "Biotransformations of proline by 2-oxoglutarate-dependent hydroxylases". Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19532/.
Texto completoShibasaki, Takeshi. "SCREENING AND APPLIED STUDIES OF MICROBIAL PROLINE HYDROXYLASES". Kyoto University, 2001. http://hdl.handle.net/2433/150792.
Texto completoWhite, Tommi Anna. "Structural and functional studies of proline catabolic enzymes". Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4760.
Texto completoThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 24, 2009) Vita. Includes bibliographical references.
UEDA, Akihiro, Weiming SHI, Takiko SHIMADA, Hiroshi MIYAKE y Tetsuko TAKABE. "Altered expression of barley proline transporter causes different growth responses in Arabidopsis". Springer, 2007. http://hdl.handle.net/2237/8780.
Texto completoEriksen, Heidi Sofie. "The synthesis and use of polymer supported β amino sulfur containing catalysts". Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248596.
Texto completoNguyen, Thi-Huong. "Synthèse de nouveaux catalyseurs chiraux à base de la L-proline. Applications en catalyse asymétrique". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112382.
Texto completoFor many years, multifunctional chiral phosphines have proven to be powerful synthetic tools in asymmetric organocatalysis. These catalysts, containing Lewis basic and Brnsted acidic sites, have received considerable attention owing to their highly efficiency to create C-C bond by asymmetric organocatalysis. To our knowledge, the synthesis of organocatalysts type thiourea-phosphine derivatives (L) -proline have never been described in the literature. In this work, we wish to report the synthesis of new family of bifunctional chiral thiourea-phosphine organocatalyst derived from L-proline, a natural available product. We developed efficient methods to prepare three families of phosphine thiourea derived from L-proline. Thus, Seven new enantiopure compounds were synthesized in this study. They were used as catalyst asymmetric reaction catalyzed by phosphines: [3+2] cyclisation, Baylis-Hillman reaction, Friedel-Crafts reaction and nucleophilic substitution
Picard, François J. "Genetics of arginine and proline biosynthesis in Neisseria gonorrhoeae". Thesis, University of Ottawa (Canada), 1991. http://hdl.handle.net/10393/7669.
Texto completoDigennaro, Angela [Verfasser]. "Proline-Quaterthiophene hybrids: Synthesis and self-assembly / Angela Digennaro". Ulm : Universität Ulm, 2017. http://d-nb.info/112490249X/34.
Texto completoWood, Nicholas James. "The role of proline in osmoregulation by a streptomycete". Thesis, University of Warwick, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319812.
Texto completoMurray, Nicola Jane. "NMR studies of salivary proline-rich proteins and tannins". Thesis, University of Sheffield, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284595.
Texto completoSwingler, Tracey. "Transcriptional repression by the proline rich homeodomain protein (PRH)". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419215.
Texto completoRoosens, Nancy. "Proline biosynthesis related to salt stress in higher plants". Doctoral thesis, Universite Libre de Bruxelles, 1999. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211926.
Texto completoObayashi, Yoko. "Novel physiological function of proline and mTOR regulator tuberin". Kyoto University, 2018. http://hdl.handle.net/2433/232154.
Texto completoAillard, Boris. "Small molecule mimics of trans-proline : synthesis and applications". Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/367097/.
Texto completoVoss, Emelyne. "Synthèse d’Analogues Bis-azotés de la Proline et Applications". Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL059N/document.
Texto completoThe peptidic bond in a peptide or a protein is usually flat and in trans conformation for the majority of amino acids. The situation is a little bit different upstream the proline: the thermodynamic barrier which opposes the rotation of the amide bond is weaker and the tendency of the bond to remain flat is lesser. So, this AA-Pro bond can adopt a cis conformation, leading to the formation of a turn in the peptidic chain. This work describes the synthesis and the chemical reactivity of new bis-nitrogen analogous of proline in solution to facilitate the cis conformation of a AA-PΨPro bond. The conformational impact that these residues may generate in pseudopeptides is also exposed.Initially, a new access road to the orthogonally protected and enantiomerically pure δ-azaproline has been developed by exploiting previous work on the synthesis of α- hydrazinoesters and N-aminodipeptides. The study of the reactivity of this pseudoproline helped define the best conditions for forming pseudotripeptides of formula P1-AA1--δ-azaPro-AA3-P3. It also guided the work, in a second step, towards the synthesis of pseudopeptide incorporating a pyrazole acid motif. Finally, the structure of the prepared compounds was analyzed by NMR, IR and molecular modeling. Examination of the P1-AA1-δ-azaPro(Boc)-AA3-P3 revealed the formation of a pseudocycle C7 by a Hydrogen bond, favoring the trans conformation of the AA1-δ-azaPro bond, while the absence of Boc function seems to favor the cis conformation of this bond
Voinchet, Anne. "Métabolisme du cristallin". Paris 5, 1990. http://www.theses.fr/1990PA05P053.
Texto completoZhang, Min. "Crystallographic studies of the E. coli puta proline dehydrogenase domain /". free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1426119.
Texto completoLilley, Ian Andrew. "Synthetic studies using chiral stabilised azomethine ylids". Thesis, University of Oxford, 1995. https://ora.ox.ac.uk/objects/uuid:64d5745b-e6ef-4a77-8abe-b01f1c627e8f.
Texto completoTouchal, Samira. "Synthèse de nouveaux matériaux polymères hydrosolubles : application à la séparation de mélanges de solvants organiques de type alcool / éther par pervaporation". Vandoeuvre-les-Nancy, INPL, 2003. http://docnum.univ-lorraine.fr/public/INPL_T_2003_TOUCHAL_S.pdf.
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