Artículos de revistas:

1

Vallet-Regí, María, Francisco Balas y Daniel Arcos. "Mesoporous Materials for Drug Delivery". Angewandte Chemie International Edition 46, n.º 40 (8 de octubre de 2007): 7548–58. http://dx.doi.org/10.1002/anie.200604488.

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2

Wang, Yanan, Fang Li, Junbo Xin, Jia Xu, Guanghua Yu y Qin Shi. "Mesoporous Drug Delivery System: From Physical Properties of Drug in Solid State to Controlled Release". Molecules 28, n.º 8 (12 de abril de 2023): 3406. http://dx.doi.org/10.3390/molecules28083406.

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Mesoporous materials, which exhibit great potential in the control of polymorphs and delivery of poorly water-soluble drugs, have obtained considerable attention in the field of pharmaceutical science. The physical properties and release behaviors of amorphous or crystalline drugs may be affected by formulating them into mesoporous drug delivery systems. In the past few decades, an increasing amount of papers have been written about mesoporous drug delivery systems, which play a crucial role in improving the properties of drugs. Herein, mesoporous drug delivery systems are comprehensively reviewed in terms of their physicochemical characteristics, control of polymorphic forms, physical stability, in vitro performance, and in vivo performance. Moreover, the challenges and strategies of developing robust mesoporous drug delivery systems are also discussed.

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3

Wang, Shaobin. "Ordered mesoporous materials for drug delivery". Microporous and Mesoporous Materials 117, n.º 1-2 (enero de 2009): 1–9. http://dx.doi.org/10.1016/j.micromeso.2008.07.002.

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4

Cauda, Valentina y Giancarlo Canavese. "Mesoporous Materials for Drug Delivery and Theranostics". Pharmaceutics 12, n.º 11 (18 de noviembre de 2020): 1108. http://dx.doi.org/10.3390/pharmaceutics12111108.

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5

Katsiotis, Christos S., Michelle Åhlén, Maria Strømme y Ken Welch. "3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs". Pharmaceutics 13, n.º 7 (18 de julio de 2021): 1096. http://dx.doi.org/10.3390/pharmaceutics13071096.

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Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms. In the present study, mesoporous materials were incorporated into a thermoplastic filament produced via hot-melt extrusion and used to produce oral dosage forms via FDM. Mesoporous materials are known to be highly effective for the amorphization and stabilization of poorly soluble drugs, and were therefore studied in order to determine their ability to enhance the drug-release properties in 3D-printed tablets. Celecoxib was selected as the model poorly soluble drug, and was loaded into mesoporous silica (MCM-41) or mesoporous magnesium carbonate. In vitro drug release tests showed that the printed tablets produced up to 3.6 and 1.5 times higher drug concentrations, and up to 4.4 and 1.9 times higher release percentages, compared to the crystalline drug or the corresponding plain drug-loaded mesoporous materials, respectively. This novel approach utilizing drug-loaded mesoporous materials in a printed tablet via FDM shows great promise in achieving personalized oral dosage forms for poorly soluble drugs.

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6

Pasqua, Luigi, Ilaria Ester De Napoli, Marzia De Santo, Marianna Greco, Enrico Catizzone, Domenico Lombardo, Gabriella Montera et al. "Mesoporous silica-based hybrid materials for bone-specific drug delivery". Nanoscale Advances 1, n.º 8 (2019): 3269–78. http://dx.doi.org/10.1039/c9na00249a.

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7

Santos, H. A., J. Salonen, L. M. Bimbo, V. P. Lehto, L. Peltonen y J. Hirvonen. "Mesoporous materials as controlled drug delivery formulations". Journal of Drug Delivery Science and Technology 21, n.º 2 (2011): 139–55. http://dx.doi.org/10.1016/s1773-2247(11)50016-4.

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8

Spiridon, Irene Alexandra, Irina Draga Cӑruntu, Iuliana Spiridon y Radu Brӑescu. "Insight into Potential Biomedical Application of Mesoporous Materials". Pharmaceutics 14, n.º 11 (4 de noviembre de 2022): 2382. http://dx.doi.org/10.3390/pharmaceutics14112382.

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The physicochemical properties of many drugs have a decisive impact on their bioavailability, as well as the pharmacokinetic efficiency in various disease therapeutics. That is why mesoporous materials have attracted a special interest in the drug delivery field, facilitating the loading of drugs into their pores due to their high surface area and porosity. The interfacial interactions established with drug molecules represent the driving force for efficient drug loading and controlled release kinetics. Moreover, these materials offer an optimal design for implantable local-delivery devices or for improving the accuracy of imaging techniques in clinical diagnosis. Their use is validated by improvements in therapeutic outcome and prevention of side effects. This review discusses the role of mesoporous materials in different biomedical applications.

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9

Yang, Piaoping, Shili Gai y Jun Lin. "Functionalized mesoporous silica materials for controlled drug delivery". Chemical Society Reviews 41, n.º 9 (2012): 3679. http://dx.doi.org/10.1039/c2cs15308d.

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10

Moritz, Michał y Małgorzata Geszke-Moritz. "Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements". Pharmaceutics 14, n.º 8 (25 de julio de 2022): 1542. http://dx.doi.org/10.3390/pharmaceutics14081542.

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Interest in the use of mesoporous materials as carriers of medicinal substances has been steadily increasing in the last two decades. Mesoporous carriers have application in the preparation of delivery systems for drugs from various therapeutic groups; however, their use as the carriers of anti-inflammatory agents is particularly marked. This review article, with about 170 references, summarizes the achievements in the application of mesoporous materials as the carriers of anti-inflammatory agents in recent years. This article will discuss a variety of mesoporous carriers as well as the characteristics of their porous structure that determine further use of these materials in the field of medical applications. Special attention will be paid to the progress observed in the construction of stimuli-responsive drug carriers and systems providing site-specific drug delivery. Subsequently, a review of the literature devoted to the use of mesoporous matrices as the carriers of anti-inflammatory drugs was carried out.

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11

Zhang, Yongxiang, Xinmin Liu, Yizhong Lu, Jincai Wang, Tingfang Dong y Xiaohong Liu. "Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers". Journal of Chemistry 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/430459.

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In this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs, but also generates several novel activities such as the enhancement of biocompatibility, selective loading drugs, and dual loading of anticancer drug and bFGF, rendering it a promising candidate to be used as a multifunctional carrier. The strategy of combination of multifunctional mesoporous silica materials with bioactive molecules could be a new effective approach to improve their capabilities in the drug delivery.

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12

Dave, Pragnesh N. y Lakha V. Chopda. "A Review on Application of Multifunctional Mesoporous Nanoparticles in Controlled Release of Drug Delivery". Materials Science Forum 781 (marzo de 2014): 17–24. http://dx.doi.org/10.4028/www.scientific.net/msf.781.17.

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In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.

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13

Sreeharsha, Nagaraja, Manish Philip, Sivadas Swathi Krishna, Vidya Viswanad, Ram Kumar Sahu, Predeepkumar Narayanappa Shiroorkar, Afzal Haq Aasif et al. "Multifunctional Mesoporous Silica Nanoparticles for Oral Drug Delivery". Coatings 12, n.º 3 (8 de marzo de 2022): 358. http://dx.doi.org/10.3390/coatings12030358.

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Nanotechnology has transformed engineering designs across a wide spectrum of materials and applications. Mesoporous Silica Nanoparticles (MSNs) are one of the new fabrications of nanostructures as medication delivery systems. MSNs have pore sizes varying from 2 to 50 nm, making them ideal for a variety of biological applications. They offer unique characteristics such as a tunable surface area, well-defined surface properties, and the ability to improve drug pharmacokinetic characteristics. Moreover, they have the potential to reduce adverse effects by delivering a precise dose of medications to a specific spot rather than the more frequent systemic delivery, which diffuses across tissues and organs. In addition, the vast number of pores allow drug incorporation and transportation of drugs to various sites making MSNs a feasible platform for orally administered drugs. Though the oral route is the most suitable and convenient platform for drug delivery, conventional oral drug delivery systems are associated with several limitations. Surpassing gastrointestinal barriers and the low oral bioavailability of poorly soluble medicines pose a major challenge in the pharmaceutical industry. This review provides insights into the role of MSNs and its mechanism as an oral drug delivery system.

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14

Zhang, Qian, Minying Wu, Yuanyuan Fang, Chao Deng, Hsin-Hui Shen, Yi Tang y Yajun Wang. "Dendritic Mesoporous Silica Hollow Spheres for Nano-Bioreactor Application". Nanomaterials 12, n.º 11 (6 de junio de 2022): 1940. http://dx.doi.org/10.3390/nano12111940.

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Mesoporous silica materials have attracted great research interest for various applications ranging from (bio)catalysis and sensing to drug delivery. It remains challenging to prepare hollow mesoporous silica nanoparticles (HMSN) with large center-radial mesopores that could provide a more efficient transport channel through the cell for guest molecules. Here, we propose a novel strategy for the preparation of HMSN with large dendritic mesopores to achieve higher enzyme loading capacity and more efficient bioreactors. The materials were prepared by combining barium sulfate nanoparticles (BaSO4 NP) as a hard template and the in situ-formed 3-aminophenol/formaldehyde resin as a porogen for directing the dendritic mesopores’ formation. HMSNs with different particle sizes, shell thicknesses, and pore structures have been prepared by choosing BaSO4 NP of various sizes and adjusting the amount of tetraethyl orthosilicate added in synthesis. The obtained HMSN-1.1 possesses a high pore volume (1.07 cm3 g−1), a large average pore size (10.9 nm), and dendritic mesopores that penetrated through the shell. The advantages of HMSNs are also demonstrated for enzyme (catalase) immobilization and subsequent use of catalase-loaded HMSNs as bioreactors for catalyzing the H2O2 degradation reaction. The hollow and dendritic mesoporous shell features of HMSNs provide abundant tunnels for molecular transport and more accessible surfaces for molecular adsorption, showing great promise in developing efficient nanoreactors and drug delivery vehicles.

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15

Tamayo, Aitana, M. Alejandra Mazo, Roberto Ruiz-Caro, Araceli Martín-Illana, Luis Miguel Bedoya, M. Dolores Veiga-Ochoa y Juan Rubio. "Mesoporous silicon oxycarbide materials for controlled drug delivery systems". Chemical Engineering Journal 280 (noviembre de 2015): 165–74. http://dx.doi.org/10.1016/j.cej.2015.05.111.

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16

Manzano, Miguel y María Vallet-Regí. "New developments in ordered mesoporous materials for drug delivery". Journal of Materials Chemistry 20, n.º 27 (2010): 5593. http://dx.doi.org/10.1039/b922651f.

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17

Singh, Pritam y Kamalika Sen. "Contemporary mesoporous materials for drug delivery applications: a review". Journal of Porous Materials 25, n.º 4 (13 de septiembre de 2017): 965–87. http://dx.doi.org/10.1007/s10934-017-0508-9.

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18

Vallet-Regí, María, Isabel Izquierdo-Barba y Montserrat Colilla. "Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 370, n.º 1963 (28 de marzo de 2012): 1400–1421. http://dx.doi.org/10.1098/rsta.2011.0258.

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This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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19

Yun, Hui Suk. "Design of Hierarchically Porous Materials for Bone Tissue Regeneration". Key Engineering Materials 441 (junio de 2010): 139–53. http://dx.doi.org/10.4028/www.scientific.net/kem.441.139.

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Mesoporous materials synthesized using a polymer templating route have attracted considerable attention in the field of bone tissue regeneration because their unique pore textural properties (high specific surface area, pore volume and controllable mesopore structure) can promote rapid bone formation. In addition, their potential use as a drug delivery system has been highlighted. The scaffolds in bone tissue regeneration should contain 3D interconnected pores ranging in size from 10 to 1000 μm for successful cell migration, nutrient delivery, bone in-growth and vascularization. Meso-sized pores are too small to carry out these roles, even though mesoporous materials have attractive functionalities for bone tissue regeneration. Therefore, a technique linking mesoporous materials with the general scaffolds is required. This paper reviews recent studies relating the development of new porous scaffolds containing mesopores for using in bone tissue regeneration. All the suggested methods, such as a combination of polymer templating methods and rapid prototyping technique can provide hierarchically 3D porous bioactive scaffolds with well interconnected pore structures in the nano to macro size range, good molding capability, biocompatibility, and bioactivity. The new fabrication techniques suggested can potentially be used to design ideal scaffolds in bone tissue regeneration.

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20

Limongi, Tania, Francesca Susa, Marco Allione y Enzo di Fabrizio. "Drug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds". Pharmaceutics 12, n.º 9 (8 de septiembre de 2020): 851. http://dx.doi.org/10.3390/pharmaceutics12090851.

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Mesoporous materials are structures characterized by a well-ordered large pore system with uniform porous dimensions ranging between 2 and 50 nm. Typical samples are zeolite, carbon molecular sieves, porous metal oxides, organic and inorganic porous hybrid and pillared materials, silica clathrate and clathrate hydrates compounds. Improvement in biochemistry and materials science led to the design and implementation of different types of porous materials ranging from rigid to soft two-dimensional (2D) and three-dimensional (3D) skeletons. The present review focuses on the use of three-dimensional printed (3DP) mesoporous scaffolds suitable for a wide range of drug delivery applications, due to their intrinsic high surface area and high pore volume. In the first part, the importance of the porosity of materials employed for drug delivery application was discussed focusing on mesoporous materials. At the end of the introduction, hard and soft templating synthesis for the realization of ordered 2D/3D mesostructured porous materials were described. In the second part, 3DP fabrication techniques, including fused deposition modelling, material jetting as inkjet printing, electron beam melting, selective laser sintering, stereolithography and digital light processing, electrospinning, and two-photon polymerization were described. In the last section, through recent bibliographic research, a wide number of 3D printed mesoporous materials, for in vitro and in vivo drug delivery applications, most of which relate to bone cells and tissues, were presented and summarized in a table in which all the technical and bibliographical details were reported. This review highlights, to a very cross-sectional audience, how the interdisciplinarity of certain branches of knowledge, as those of materials science and nano-microfabrication are, represent a growing valuable aid in the advanced forum for the science and technology of pharmaceutics and biopharmaceutics.

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21

Zhang, Wei, Nan Zheng, Lu Chen, Luyao Xie, Mingshu Cui, Sanming Li y Lu Xu. "Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin". Pharmaceutics 11, n.º 1 (23 de diciembre de 2018): 4. http://dx.doi.org/10.3390/pharmaceutics11010004.

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The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.

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22

Manzano, Miguel y María Vallet‐Regí. "Mesoporous Silica Nanoparticles for Drug Delivery". Advanced Functional Materials 30, n.º 2 (6 de septiembre de 2019): 1902634. http://dx.doi.org/10.1002/adfm.201902634.

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23

Siefker, Justin, Pankaj Karande y Marc-Olivier Coppens. "Packaging biological cargoes in mesoporous materials: opportunities for drug delivery". Expert Opinion on Drug Delivery 11, n.º 11 (12 de julio de 2014): 1781–93. http://dx.doi.org/10.1517/17425247.2014.938636.

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24

Yang, Piaoping, Shili Gai y Jun Lin. "ChemInform Abstract: Functionalized Mesoporous Silica Materials for Controlled Drug Delivery". ChemInform 43, n.º 31 (5 de julio de 2012): no. http://dx.doi.org/10.1002/chin.201231267.

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25

Chen, Huangqin, Xin Qiu, Tian Xia, Qing Li, Zhehan Wen, Bin Huang y Yuesheng Li. "Mesoporous Materials Make Hydrogels More Powerful in Biomedicine". Gels 9, n.º 3 (9 de marzo de 2023): 207. http://dx.doi.org/10.3390/gels9030207.

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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26

Tang, Xin De, Fa Qi Yu, Ye Chen y Mei Shan Pei. "Thermo-Sensitive Nanogated System Based on Polymer-Modified Mesoporous Silica Hybrid Nanoparticles". Key Engineering Materials 538 (enero de 2013): 93–96. http://dx.doi.org/10.4028/www.scientific.net/kem.538.93.

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Mesoporous silica nanoparticles (MSNs) have been employed as a versatile solid support for constructing a variety of hybrid materials for controlled drug delivery. Controlled release systems that integrate external stimuli with nanocarriers have attracted much attention for sensors and drug delivery applications. Mesoporous silica nanoparticles grafted with thermo-sensitive polymers on the surface were fabricated via “grafting to” approach through chemical coupling reaction. The encapsulation and release of drug based on the thermo-sensitive nanogated system were investigated. The thermo-sensitive nanogated system can be expected as one of the promising candidates for drug delivery and controlled release.

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27

Zeng, Wei. "Effects of Four Mesostructures on their Drug Release Properties". Advanced Materials Research 645 (enero de 2013): 125–28. http://dx.doi.org/10.4028/www.scientific.net/amr.645.125.

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Five ordered mesoporous materials, SBA-1, MCM-48, SBA-7, MCM-41 and SBA-15, were prepared and tested as mesophase drug delivery systems with an anti-inflammatory drug, ibuprofen. The results of these mesostructures on in vitro ibuprofen delivery indicated that the mesoporous materials with cage-like structure, SBA-1 and SBA-7, had unfavorable load and release properties. MCM-48 also showed fast release rate due to its opening channel. However, the hexagonal mesostructure in MCM-41 and SAB-15 was advantageous for extending drug release rate although a little difference existed between them. Compared with commercial ibuprofen capsule, the release system based on MCM-41 materials displayed the drug efficacy in a longer time.

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28

Petrescu, Marilena, Raul Augustin Mitran, Cristian Matei, Marius Radulescu y Daniela Berger. "Silica-Alginate Beads for Intestinal Ketoprofen Delivery". Revista de Chimie 69, n.º 12 (15 de enero de 2019): 3416–22. http://dx.doi.org/10.37358/rc.18.12.6761.

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Herein, studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported. The influence of surface properties, pore size and geometry of mesoporous silica carriers on the ketoprofen release kinetics was studied by using pristine and 3-aminopropyl functionalized MCM 41 (Mobile Composition of Matter) and MCF (mesocellular foam silica) materials. The ketoprofen loaded mesoporous silica coated with alginate is a pH-triggered system able to slow down the drug release rate in the targeted environment.

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29

Goscianska, Joanna, Aleksander Ejsmont, Anita Kubiak, Dominika Ludowicz, Anna Stasiłowicz y Judyta Cielecka-Piontek. "Amine-Grafted Mesoporous Carbons as Benzocaine-Delivery Platforms". Materials 14, n.º 9 (24 de abril de 2021): 2188. http://dx.doi.org/10.3390/ma14092188.

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Smart porous carriers with defined structure and physicochemical properties are required for releasing the therapeutic drug with precise control of delivery time and location in the body. Due to their non-toxicity, ordered structure, and chemical and thermal stability, mesoporous carbons can be considered modern carriers for active pharmaceutical ingredients whose effectiveness needs frequent dosing algorithms. Here, the novel benzocaine delivery systems based on ordered mesoporous carbons of the cubic structure were obtained with the use of a hard template method and functionalization with amine groups at 40 °C for 8 h. It has been shown that amine grafting strongly modifies the surface chemistry and textural parameters of carbons. All samples indicated good sorption ability towards benzocaine, with evident improvement following the functionalization with the amine groups. The sorption capacity and drug release kinetics were strongly affected by the porosity of carbon carriers and the surface functional groups. The smallest amount of benzocaine (~12%) was released from pristine mesoporous carbon, which could be correlated with strong API–carrier interactions. Faster and more efficient release of the drug was observed in the case of triethylenetetramine modified carbon (~62%). All benzocaine delivery platforms based on amine-grafted mesoporous carbons revealed high permeability through the artificial membrane.

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30

Qin, Yujie, Xiaoqian Shan, Yu Han, Hang Jin y Ying Gao. "Study of pH-Responsive and Polyethylene Glycol-Modified Doxorubicin-Loaded Mesoporous Silica Nanoparticles for Drug Delivery". Journal of Nanoscience and Nanotechnology 20, n.º 10 (1 de octubre de 2020): 5997–6006. http://dx.doi.org/10.1166/jnn.2020.17885.

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Tumor-targeted drug delivery systems represent challenging and widely investigated strategies to enhance cancer chemotherapy. In this study, we introduce a novel high-hydrophilic mesoporous silica nanoparticle system with a pH-sensitive drug release. The resultant composite nanoparticles appear as spheres of uniform size (450±25 nm) with a porous structure, which enables a high drug-loading ratio. Through modification of chitosan and polyethylene glycol monomethyl ether, the modified mesoporous silica was non-toxic to normal cells, but effective at inducing tumor cell death. With regard to the characteristics of drug release, the modified mesoporous silica clearly displayed a pH-stimulated release of the model drug doxorubicin hydrochloride in an acidic phosphate buffer solution (pH 4.0 and 6.0). The release was much greater than that observed in neutral or alkaline phosphate buffer solutions (pH 7.3 and 8.0). Furthermore, the release behavior was in accordance with the Higuchi model, indicating that this modified mesoporous silica drug delivery system can exhibit controlled release. The above results imply that the modified mesoporous silica is an effective drug delivery system for cancer therapy.

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31

Tang, Shaoheng, Xiaoqing Huang, Xiaolan Chen y Nanfeng Zheng. "Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery". Advanced Functional Materials 20, n.º 15 (24 de junio de 2010): 2442–47. http://dx.doi.org/10.1002/adfm.201000647.

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32

Gulzar, Arif, Shili Gai, Piaoping Yang, Chunxia Li, Mohd Bismillah Ansari y Jun Lin. "Stimuli responsive drug delivery application of polymer and silica in biomedicine". Journal of Materials Chemistry B 3, n.º 44 (2015): 8599–622. http://dx.doi.org/10.1039/c5tb00757g.

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33

Vallet-Regí, María. "Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine". ISRN Materials Science 2012 (16 de agosto de 2012): 1–20. http://dx.doi.org/10.5402/2012/608548.

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Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

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34

Almásy, László, Ana-Maria Putz, Qiang Tian, Gennady Kopitsa, Tamara Khamova, Réka Barabás, Melinda Rigó et al. "Hybrid mesoporous silica with controlled drug release". Journal of the Serbian Chemical Society 84, n.º 9 (2019): 1027–39. http://dx.doi.org/10.2298/jsc181109009a.

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The mesoporous silica particles were prepared by the sol?gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammonium bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated precursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.

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35

Li, Dongdong, Yuntao Zhu y Zhiqiang Liang. "Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery". Materials Research Bulletin 48, n.º 6 (junio de 2013): 2201–4. http://dx.doi.org/10.1016/j.materresbull.2013.02.049.

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36

Lengert, Ekaterina, Roman Verkhovskii, Nikolai Yurasov, Elina Genina y Yulia Svenskaya. "Mesoporous carriers for transdermal delivery of antifungal drug". Materials Letters 248 (agosto de 2019): 211–13. http://dx.doi.org/10.1016/j.matlet.2019.04.028.

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37

Dumontel, Bianca, Verónica Conejo-Rodríguez, María Vallet-Regí y Miguel Manzano. "Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery". Pharmaceutics 15, n.º 2 (29 de enero de 2023): 447. http://dx.doi.org/10.3390/pharmaceutics15020447.

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In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New nanotechnological approaches have been developed with the objective of utilizing natural biopolymers as smart materials in drug delivery applications. Natural biopolymers are sensitive to various physicochemical and biological stimuli and are endowed with intrinsic biodegradability, biocompatibility, and low immunogenicity. Their use as biocompatible smart coatings has extensively been investigated in the last few years. This review summarizes the MSNs coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs, which conjugate the nanocarrier features of mesoporous silica with the biocompatibility and controlled delivery provided by natural coatings, have shown promising therapeutic outcomes and the potential to emerge as valuable candidates for the selective treatment of various diseases.

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38

Kesse, Samuel, Kofi Boakye-Yiadom, Belynda Ochete, Yaw Opoku-Damoah, Fahad Akhtar, Mensura Filli, Muhammad Asim Farooq et al. "Mesoporous Silica Nanomaterials: Versatile Nanocarriers for Cancer Theranostics and Drug and Gene Delivery". Pharmaceutics 11, n.º 2 (13 de febrero de 2019): 77. http://dx.doi.org/10.3390/pharmaceutics11020077.

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Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are being thought of by researchers as materials that can be used to effect great change in cancer therapies, gene delivery, and drug delivery because of their optically transparent properties, flexible size, functional surface, low toxicity profile, and very good drug loading competence. Mesoporous silica nanoparticles (MSNPs) show a very high loading capacity for therapeutic agents. It is well known that cancer is one of the most severe known medical conditions, characterized by cells that grow and spread rapidly. Thus, curtailing cancer is one of the greatest current challenges for scientists. Nanotechnology is an evolving field of study, encompassing medicine, engineering, and science, and it has evolved over the years with respect to cancer therapy. This review outlines the applications of mesoporous nanomaterials in the field of cancer theranostics, as well as drug and gene delivery. MSNs employed as therapeutic agents, as well as their importance and future prospects in the ensuing generation of cancer theranostics and drug and therapeutic gene delivery, are discussed herein. Thus, the use of mesoporous silica nanomaterials can be seen as using one stone to kill three birds.

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39

Mirzaei, Masoud, Malihe Babaei Zarch, Mahdieh Darroudi, Khalilollah Sayyadi, Seyed Tahmoures Keshavarz, Jalil Sayyadi, Azadeh Fallah y Hajar Maleki. "Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts". Applied Sciences 10, n.º 21 (26 de octubre de 2020): 7533. http://dx.doi.org/10.3390/app10217533.

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The application of silica mesoporous structures in drug delivery and the removal of pollutants and organic compounds through catalytic reactions is increasing due to their unique characteristics, including high loading capacities, tunable pores, large surface areas, sustainability, and so on. This review focuses on very well-studied class of different construction mesoporous silica nano(particles), such as MCM-41, SBA-15, and SBA-16. We discuss the essential parameters involved in the synthesis of these materials with providing a diverse set of examples. In addition, the recent advances in silica mesoporous structures for drug delivery and catalytic applications are presented to fill the existing gap in the literature with providing some promising examples on this topic for the scientists in both industry and academia active in the field. Regarding the catalytic applications, mesoporous silica particles have shown some promises to remove the organic pollutants and to synthesize final products with high yields due to the ease with which their surfaces can be modified with various ligands to create appropriate interactions with target molecules. In the drug delivery process, as nanocarriers, they have also shown very good performance thanks to the easy surface functionalization but also adjustability of their porosities to providing in-vivo and in-vitro cargo delivery at the target site with appropriate rate.

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40

López, T., Fernando Edgar Krötzsch, E. Ortiz Islas, M. Alvarez Lemus, E. Balsadella, J. Ma Martínez-Blanes y José Antonio Odriozola. "Release Properties and Acute Biosecurity Determination of Collagen-Polyvinylpyrrolidone Loaded in Ordered Mesoporous Silica". Key Engineering Materials 391 (octubre de 2008): 169–84. http://dx.doi.org/10.4028/www.scientific.net/kem.391.169.

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Mesoporous silica type SBA-15 has high specific surface area, well ordered pores and renders larges volumes, reasons for its potential use in controlled drug delivery system; in addition its non toxic nature and good biocompatibility. The aim of this work is to determine the feasibility of loading collagen-polyvinylpyrrolidone (collagen-PVP) molecules into Biocompatible Nanostructured Ordered Mesoporous Silica (BINOM-Silica). Collagen-PVP has several medical uses, such as fibrolytic activity and tissue regeneration. Therefore, this BINOM-Silica/collagen- PVP material could be used as drug delivery system for hypertrophic scarring. Different BINOMSilica materials were prepared using a triblock copolymer in an acid medium and stabilized at 557°C and later, collagen-PVP was loaded into the material. The small angle powder X-ray diffraction patterns of BINOM-Silica materials, in some cases, indicate the existence of a high degree of hexagonal mesoscopic organization. The nitrogen sorption isotherms are type IV typical of mesoporous materials with large surface area. In vitro release of collagen-PVP was carried out by mean of UV/VIS spectroscopy. The cumulative release profiles of Silica-collagen PVP in distilled water indicate a two step release, an initial fast release and a relatively slow subsequent release, indicating an appropriate delivery of collagen-PVP for therapeutic administration. BINOMSilica/ collagen-PVP intradermical administration stimulated inflammatory infiltrates only in an acute phase (day 3), demonstrating that silica materials and their combination with chemical and biological drugs could be safe for therapeutics. The absence of inflammatory infiltrates at day 7 suggested an appropriate integration of BINOM-Silica/collagen-PVP into the tissue. These results indicate that we obtained biocompatible nanostructured ordered mesoporous silica materials useful for delivery systems.

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41

Chen, Minmin, Jinxia Hu, Cancan Bian, Chenghao Zhu, Chen Chen, Zhijun Guo, Zhimin Zhang, Godfred Amfo Agyekum, Zhuoqi Zhang y Xichuan Cao. "pH-Responsive and Biodegradable ZnO-Capped Mesoporous Silica Composite Nanoparticles for Drug Delivery". Materials 13, n.º 18 (7 de septiembre de 2020): 3950. http://dx.doi.org/10.3390/ma13183950.

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As a drug delivery system (DDS), traditional mesoporous silica nanoparticles (MSNs) suffer from bioaccumulation in vivo and premature drug release in systemic circulation due to low degradation rate and lack of protective gatekeeper. Herein, we developed a safe and intelligent DDS with characteristics of pH-responsive biodegradation and controlled drug release based on mesoporous silica composite nanoparticles (MSCNs) capped with ZnO quantum dots (ZnO QDs). Acidic degradable MSCNs were successfully synthesized by doping Ca2+ and PO43− into the MSNs’ framework. The in vitro doxorubicin hydrochloride (DOX) release was inhibited at neutral pH 7.4 but triggered significantly at pH 5.0 due to the dissociation of ZnO caps. The internalization behavior and cytotoxicity of 4T1 cells indicated MSCNs-ZnO could efficiently deliver DOX into the cells with significant antitumor activity. Such a DDS with pH-responsive biodegradation and controlled drug release has promising potential for cancer therapy.

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42

Martínez-Carmona, Marina, Yurii Gun’ko y María Vallet-Regí. "Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection". Pharmaceutics 10, n.º 4 (15 de diciembre de 2018): 279. http://dx.doi.org/10.3390/pharmaceutics10040279.

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Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the multiple ways of action in which MSM can be used to fight bacterial infection, including early detection, drug release, targeting bacteria or biofilm, antifouling surfaces, and adjuvant capacity. This review focus mainly on those that act as a drug delivery system, and therefore that have an essential characteristic, which is their great loading capacity. Since MSM have advantages in all stages of combatting bacterial infection; its prevention, detection and finally in its treatment, we can venture to talk about them as the “nightmare of bacteria”.

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43

Carino, Ida Stefania, Luigi Pasqua, Flaviano Testa, Rosario Aiello, Francesco Puoci, Francesca Iemma y Nevio Picci. "Silica-Based Mesoporous Materials as Drug Delivery System for Methotrexate Release". Drug Delivery 14, n.º 8 (enero de 2007): 491–95. http://dx.doi.org/10.1080/10717540701606244.

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44

Angelos, Sarah, Monty Liong, Eunshil Choi y Jeffrey I. Zink. "Mesoporous silicate materials as substrates for molecular machines and drug delivery". Chemical Engineering Journal 137, n.º 1 (15 de marzo de 2008): 4–13. http://dx.doi.org/10.1016/j.cej.2007.07.074.

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45

Saha, Dipendu, Kaitlyn E. Warren y Amit K. Naskar. "Soft-templated mesoporous carbons as potential materials for oral drug delivery". Carbon 71 (mayo de 2014): 47–57. http://dx.doi.org/10.1016/j.carbon.2014.01.005.

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46

Goscianska, Joanna, Aleksander Ejsmont, Anna Olejnik, Dominika Ludowicz, Anna Stasiłowicz y Judyta Cielecka-Piontek. "Design of Paracetamol Delivery Systems Based on Functionalized Ordered Mesoporous Carbons". Materials 13, n.º 18 (18 de septiembre de 2020): 4151. http://dx.doi.org/10.3390/ma13184151.

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The oxidized ordered mesoporous carbons of cubic and hexagonal structure obtained by two templating methods (soft and hard) were applied for the first time as delivery systems for paracetamol—the most common antipyretic and analgesic drug in the world. The process of carbon oxidation was performed using an acidic ammonium persulfate solution at 60 °C for 6 h. The functionalization was found to reduce the specific surface area and pore volume of carbon materials, but it also led to an increasing number of acidic oxygen-containing functional groups. The most important element and the novelty of the presented study was the evaluation of adsorption and release ability of carbon carriers towards paracetamol. It was revealed that the sorption capacity and the drug release rate were mainly affected by the materials’ textural parameters and the total amount of surface functional groups, notably different in pristine and oxidized samples. The adsorption of paracetamol on the surface of ordered mesoporous carbons occurred according to different mechanisms: donor–acceptor complexes and hydrogen bond formation. The adsorption kinetics was assessed using pseudo-first- and pseudo-second-order models. The regression results indicated that the adsorption kinetics was more accurately represented by the pseudo-second-order model. Paracetamol was adsorbed onto the carbon materials studied following the Langmuir type isotherm. The presence of oxygen-containing functional groups on the surface of ordered mesoporous carbons enhanced the amount of paracetamol adsorbed and its release rate. The optimal drug loading capacity and expected release pattern exhibited oxidized ordered mesoporous carbon with a hexagonal structure obtained by the hard template method.

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47

Sousa, Andreza de y Edésia Martins Barros de Sousa. "Ordered mesoporous silica carrier system applied in nanobiothecnology". Brazilian Archives of Biology and Technology 48, spe2 (octubre de 2005): 243–50. http://dx.doi.org/10.1590/s1516-89132005000700036.

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Ordered mesoporous materials like SBA15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). This particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. The characteristics of SBA-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. The calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. The modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections between mesopores. Aging the materials at a higher temperature resulted in no microporosity and this fact influenced the control of the release of the model drug.

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48

Pandele, Andreea Madalina, Corina Andronescu, Adi Ghebaur, Sorina Alexandra Garea y Horia Iovu. "New Biocompatible Mesoporous Silica/Polysaccharide Hybrid Materials as Possible Drug Delivery Systems". Materials 12, n.º 1 (20 de diciembre de 2018): 15. http://dx.doi.org/10.3390/ma12010015.

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A high number of studies support the use of mesoporous silica nanoparticles (MSN) as carriers for drug delivery systems due to its high biocompatibility both in vitro and in vivo, its large surface area, controlled pore size and, more than this, its good excretion capacity from the body. In this work we attempt to establish the optimal encapsulation parameters of benzalkonium chloride (BZC) into MSN and further study its drug release. The influence of different parameters towards the drug loading in MSN such as pH, contact time and temperature were considered. The adsorption mechanism of the drug has been determined by using the equilibrium data. The modification process was proved using several methods such as Fourier transform-infrared (FT-IR), ultraviolet-visible (UV-VIS), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Since MSN shows a lower drug release amount due to the agglomeration tendency, in order to increase MSN dispersion and drug release amount from MSN, two common biocompatible and biodegradable polymers were used as polymer matrix in which the MSN-BZC can be dispersed. The drug release profile of the MSN-BZC and of the synthesized hybrid materials were studied both in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Polymer-MSN-BZC hybrid materials exhibit a higher drug release percent than the pure MSN-BZC when a higher dispersion is achieved. The dispersion of MSN into the hybrid materials was pointed out in scanning electron microscope (SEM) images. The release mechanism was determined using four mathematic models including first-order, Higuchi, Korsmeyer–Peppas and Weibull.

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49

Song, Wanpeng. "The mechanism and design strategy of metal-organic frameworks in drug delivery". Applied and Computational Engineering 7, n.º 1 (21 de julio de 2023): 188–95. http://dx.doi.org/10.54254/2755-2721/7/20230435.

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In the field of drug transport, the traditional drugs used for drug delivery are organic, inorganic, and complex. The organic polymer system and liposome system can have good biocompatibility, but the porosity of the polymer cannot be determined, and the medicine cannot be given a controlled release. In contrast, inorganic materials such as microporous zeolite and mesoporous silicon can achieve controlled drug release due to their definite relative porosity, but their drug-loading capacity and poor biocompatibility cannot be widely used for drug delivery. The materials of the new MOFs can synthesize the advantages of the two, with controlled drug release, biocompatibility, and good flexibility, that is, the performance of targeted drug delivery. This paper focuses on the mechanism of MOFs in drug transport and the related applications of MOFs in transporting small molecules, macromolecular drugs, and the surface modification methods of MOFs. The present paper concludes that MOFs can be widely used to transport macromolecules and small-molecule drugs and that drug targeting can be improved by surface modification. This paper hopes to provide suggestions and guidance for designing future MOF materials for DDS, to promote the application efficiency of nanomaterials in relevant aspects, and to achieve efficient, highly selective and highly stable drug delivery.

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50

Asefa, Tewodros y Zhimin Tao. "Mesoporous silica and organosilica materials — Review of their synthesis and organic functionalization". Canadian Journal of Chemistry 90, n.º 12 (diciembre de 2012): 1015–31. http://dx.doi.org/10.1139/v2012-094.

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Mesoporous silica and organosilica materials are a class of nanostructured materials that have porous structures with tunable nanometer pores, large surface areas, high pore volumes, and, in some cases, well-ordered mesostructures. Furthermore, in the case of mesoporous organosilicas, the materials possess various types of organic functional groups. This review highlights the different synthetic methods developed for mesoporous silica and organosilica nanomaterials. The review also discusses the various synthetic strategies used to functionalize the surfaces of mesoporous silica materials and produce highly functionalized mesoporous materials. Rational design and synthetic methods developed to place judiciously chosen one or more than one type of functional group(s) on the surfaces of mesoporous silica materials and generate monofunctional and multifunctional mesoporous silica materials are also introduced. These organic functionalization methods have made possible the synthesis of organically functionalized mesoporous silicas and mesoporous organosilicas with various interesting properties and many potential applications in different areas, ranging from catalysis to drug delivery and biosensing.

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