Literatura académica sobre el tema "Meninges, neural stem cells, postnatal neurogenesis"

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Artículos de revistas sobre el tema "Meninges, neural stem cells, postnatal neurogenesis"

1

Ban, Jelena, and Miranda Mladinic. "Spinal cord neural stem cells heterogeneity in postnatal development." STEMedicine 1, no. 1 (2020): e19. http://dx.doi.org/10.37175/stemedicine.v1i1.19.

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Neural stem cells are capable of generating new neurons during development as well as in the adulthood and represent one of the most promising tools to replace lost or damaged neurons after injury or neurodegenerative disease. Unlike the brain, neurogenesis in the adult spinal cord is poorly explored and the comprehensive characterization of the cells that constitute stem cell neurogenic niche is still missing. Moreover, the terminology used to specify developmental and/or anatomical CNS regions, where neurogenesis in the spinal cord occurs, is not consensual and the analogy with the brain is
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2

Kulcenty, Katarzyna Ida, Joanna Patrycja Wróblewska, and Wiktoria Maria Suchorska. "Response of neural stem cells to ionizing radiation." Letters in Oncology Science 15, no. 4 (2019): 157–60. http://dx.doi.org/10.21641/los.15.4.115.

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Adult neurons are believed to be in a state of growth arrest. The generation of neurons is complete at the time of birth in most of the brain regions. However neurogenesis is present through life in the dentate gyrus of hippocampus and the lateral ventricles due to the presence of neural stem cells (NSC). This postnatal neurogenesis in hippocampus plays a critical role in cognitive development mainly in learning and memory functions. NSC are self-renewing, multipotent cells that generate the neurons and glia of the nervous system. Due to their high proliferation, NSC are highly sensitive to io
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3

Tsupykov, O. "Neural stem cell niches in the adult mammalian brain." Cell and Organ Transplantology 3, no. 2 (2015): 190–94. http://dx.doi.org/10.22494/cot.v3i2.13.

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Stem cells of the central nervous system have received a great deal of attention in neurobiology in the last decade. It has been shown that neurogenesis occurs in the postnatal period in specialized niches of the adult mammalian brain. The niche is a key regulator of stem cell behavior. Recent data underscore the complexity and heterogeneity of the different components of the niche, and the presence of local signaling microdomain. The review is devoted to recent views on the structural organization of neurogenic niches and regulatory factors involved at different stages of neurogenesis in the
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4

Nieto-González, Jose L., Leonardo Gómez-Sánchez, Fabiola Mavillard та ін. "Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α". Proceedings of the National Academy of Sciences 116, № 16 (2019): 8000–8009. http://dx.doi.org/10.1073/pnas.1817183116.

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Neural stem cells continuously generate newborn neurons that integrate into and modify neural circuitry in the adult hippocampus. The molecular mechanisms that regulate or perturb neural stem cell proliferation and differentiation, however, remain poorly understood. Here, we have found that mouse hippocampal radial glia-like (RGL) neural stem cells express the synaptic cochaperone cysteine string protein-α (CSP-α). Remarkably, in CSP-α knockout mice, RGL stem cells lose quiescence postnatally and enter into a high-proliferation regime that increases the production of neural intermediate progen
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5

Li, Jingzheng, Yafang Shang, Lin Wang, et al. "Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia." Science Advances 6, no. 44 (2020): eaba0682. http://dx.doi.org/10.1126/sciadv.aba0682.

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Endogenous DNA double-strand breaks (DSBs) formation and repair in neural stem/progenitor cells (NSPCs) play fundamental roles in neurogenesis and neurodevelopmental disorders. NSPCs exhibit heterogeneity in terms of lineage fates and neurogenesis activity. Whether NSPCs also have heterogeneous regulations on DSB formation and repair to accommodate region-specific neurogenesis has not been explored. Here, we identified a regional regulator Filia, which is predominantly expressed in mouse hippocampal NSPCs after birth and regulates DNA DSB formation and repair. On one hand, Filia protects stall
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6

Anesti, Maria, Stavroula Magkafa, Efstathia Prantikou, and Ilias Kazanis. "Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays." Cells 11, no. 11 (2022): 1743. http://dx.doi.org/10.3390/cells11111743.

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Two main stem cell pools exist in the postnatal mammalian brain that, although they share some “stemness” properties, also exhibit significant differences. Multipotent neural stem cells survive within specialized microenvironments, called niches, and they are vulnerable to ageing. Oligodendroglial lineage-restricted progenitor cells are widely distributed in the brain parenchyma and are more resistant to the effects of ageing. Here, we create polymorphic neural stem cell cultures and allow cells to progress towards the neuronal and the oligodendroglial lineage. We show that the divergence of c
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7

Lim, Daniel A., Yin-Cheng Huang, Tomek Swigut, et al. "Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells." Nature 458, no. 7237 (2009): 529–33. http://dx.doi.org/10.1038/nature07726.

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8

Brooks, Arrin C., and Brandon J. Henderson. "Systematic Review of Nicotine Exposure’s Effects on Neural Stem and Progenitor Cells." Brain Sciences 11, no. 2 (2021): 172. http://dx.doi.org/10.3390/brainsci11020172.

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While various modalities of chronic nicotine use have been associated with numerous negative consequences to human health, one possible benefit of nicotine exposure has been uncovered. The discovery of an inverse correlation between smoking and Parkinson’s disease, and later Alzheimer’s disease as well, motivated investigation of nicotine as a neuroprotective agent. Some studies have demonstrated that nicotine elicits improvements in cognitive function. The hippocampus, along with the subventricular zone (SVZ), is a distinct brain region that allow for ongoing postnatal neurogenesis throughout
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9

Bonfanti, Luca. "The (Real) Neurogenic/Gliogenic Potential of the Postnatal and Adult Brain Parenchyma." ISRN Neuroscience 2013 (February 6, 2013): 1–14. http://dx.doi.org/10.1155/2013/354136.

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During the last two decades basic research in neuroscience has remarkably expanded due to the discovery of neural stem cells (NSCs) and adult neurogenesis in the mammalian central nervous system (CNS). The existence of such unexpected plasticity triggered hopes for alternative approaches to brain repair, yet deeper investigation showed that constitutive mammalian neurogenesis is restricted to two small “neurogenic sites” hosting NSCs as remnants of embryonic germinal layers and subserving homeostatic roles in specific neural systems. The fact that in other classes of vertebrates adult neurogen
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10

Shah, Kushani, Gwendalyn D. King, and Hao Jiang. "A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells." Journal of Molecular Cell Biology 12, no. 1 (2019): 4–16. http://dx.doi.org/10.1093/jmcb/mjz036.

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Abstract It remains unknown whether H3K4 methylation, an epigenetic modification associated with gene activation, regulates fate determination of the postnatal neural stem and progenitor cells (NSPCs). By inactivating the Dpy30 subunit of the major H3K4 methyltransferase complexes in specific regions of mouse brain, we demonstrate a crucial role of efficient H3K4 methylation in maintaining both the self-renewal and differentiation capacity of postnatal NSPCs. Dpy30 deficiency disrupts development of hippocampus and especially the dentate gyrus and subventricular zone, the major regions for pos
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