Tesis sobre el tema "Mechanical ventilators"
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Austin, Paul Nelson. "Imposed Work of Breathing and Breathing Comfort of Nonintubated Volunters Breathing with Three Portable Ventilators and a Critical Care Ventilator". University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997382634.
Texto completoLoan, Lori A. "The relationship between ventilator inspired gas temperature and tracheal injury in neonates /". Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/7316.
Texto completoMaia, Nathalia Parente de Sousa. "A new method based on heuristic evaluation and realistic simulation for the development of mechanical ventilators centered on the user interface". Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13680.
Texto completoIntroduction: New human-machine interfaces have been developed to incorporate the new modes and ventilatory parameters. Multiple monitoring data and alarms are presented in graphical interfaces, which many consider still far from ideal for the primary users, healthcare professionals. Hypothesis: Noncompliance with the heuristic human machine interaction can compromise the usability of lung mechanical ventilators by users (doctors, nurses, physiotherapists) Objectives: To develop a new methodology for evaluating and implementing improvements on a ventilator interface pulmonary mechanical intensive care unit (ICU) second heuristic principles. Methods: An experimental study, using two methodologies: one centered on heuristic evaluation by an expert, and the second one focused on a comparative assessment by non-experts. Was held during the period from January 2013 to March 2014, the Laboratory of Respiratory (RespLab). The research was divided into three steps: 1st) evaluating the usability of six habilities (connect, adjust or alter ventilation modes and their parameters; adjust and react appropriately to different types of alarms, monitor respiratory mechanical parameters, and set the trigger mode non-invasive) ventilation interface for experts users; 2nd) Implementation of suggestions for improvements to the interface by a team of specialist engineers in mechanical ventilation (MV); 3rd) Comparison between interfaces (old and new), for users not experts, assessing six tasks (call, adjust the patient, adjust the volume control ventilation (VCV), measurement of mechanical, adjust the pressure control ventilation (PCV), pressure suport ventilation adjustment (PSV). The analysis of the 1st step was descriptive. The outcomes of the 3rd step were: executionÂs runtime and successes of tasks and usability score by analogic visual scale (AVS). Results: Step 1: Participants 8 professional experts. 93 problems were listed. The most violated principles: 5 (error prevention), 1 (Visibility of System Status) and 7 (Flexibility and efficiency of use). 2nd step: passed on and discussed all reports completed by experts users. Changes in the interface were performed following the suggestions and principles heuristics. 3rd step: VCV adjustment, mechanical ventilation and PSV adjustment required longer time to execute; p = 0.02 for the runtime of the task of connecting when first used, to the old interface; p = 0.02 for correct setting of PSV when first held in the new interface; p = 0.08 for the usability score, favoring the new interface. Conclusion: It was possible to develop a new methodology for evaluating and implementing improvements on a mechanical ventilator in ICU interface according to the heuristics.
IntroduÃÃo: Novas interfaces homem-mÃquina foram desenvolvidas para incorporar os novos modos ventilatÃrios e parÃmetros de ventilaÃÃo. MÃltiplos dados de monitorizaÃÃo e alarmes sÃo apresentados nas interfaces grÃficas, que muitos consideram ainda longe da ideal para os usuÃrios primÃrios, os profissionais de saÃde. HipÃtese: O nÃo atendimento aos princÃpios heurÃsticos da interface homem-mÃquina pode comprometer a usabilidade de ventiladores pulmonares por seus usuÃrios (mÃdicos, enfermeiros, fisioterapeutas) Objetivos: Desenvolver uma nova metodologia de avaliaÃÃo e implementaÃÃo de melhorias na interface de um ventilador pulmonar mecÃnico de uma unidade de terapia intensiva (UTI) segundo princÃpios heurÃsticos. MÃtodos: Estudo experimental, utilizando-se duas metodologias: uma centrada na avaliaÃÃo heurÃstica por expert, e a segunda, centrada em uma avaliaÃÃo comparativa por nÃo experts. Realizou-se durante o perÃodo de janeiro de 2013 a marÃo de 2014, no LaboratÃrio da RespiraÃÃo (RespLab). A pesquisa dividiu-se em 3 fases: 1Â) avaliaÃÃo da usabilidade de seis habilidades (ligar; ajustar ou alterar modos ventilatÃrios e seus parÃmetros; ajustar e reagir apropriadamente os diferentes tipos de alarmes ; monitorar parÃmetros de mecÃnica respiratÃria, acionar e ajustar o modo de ventilaÃÃo nÃo invasiva) da interface por usuÃrios experts; 2Â) ImplementaÃÃo das sugestÃes de melhorias na interface por uma equipe de engenheiros especialistas em ventilaÃÃo mecÃnica; 3Â) ComparaÃÃo entre interfaces (antiga e nova), por usuÃrios nÃo experts, avaliando 6 tarefas (ligar, ajuste do paciente, ajuste do modo de ventilaÃÃo a volume controlado (VCV), mensuraÃÃo da mecÃnica, ajuste do modo de ventilaÃÃo a pressÃo controlada (PCV), ajuste do modo de ventilaÃÃo a pressÃo de suporte (PSV). A anÃlise da 1Â fase foi descritiva. Os desfechos da 3Â fase foram: tempo de execuÃÃo e acertos das tarefas, e escore de usabilidade atravÃs da Escala Visual AnalÃgica (E.V.A.). Resultados: 1Â fase: Participaram 8 profissionais experts. Ao total, foram listados 93 problemas. Os princÃpios mais infringidos foram: 5 (PrevenÃÃo de erro), 1 (Visibilidade do Status do Sistema) e 7 (Flexibilidade e eficiÃncia de utilizaÃÃo). 2Â fase: repassados e discutidos todos os relatÃrios preenchidos pelos usuÃrios experts. ModificaÃÃes na interface foram realizadas seguindo as sugestÃes e princÃpios heurÃsticos. 3Â fase: ajuste do VCV, mecÃnica ventilatÃria e ajuste do PSV necessitaram de maior tempo para execuÃÃo; p=0,02 para o tempo de execuÃÃo da tarefa de ligar, quando usado pela primeira vez, para a interface antiga; p=0,02 para o ajuste correto do PSV quando realizado pela primeira vez na interface nova; p=0,08 para o escore de usabilidade, favorecendo a interface nova. ConclusÃo: Foi possÃvel desenvolver uma nova metodologia de avaliaÃÃo e implementaÃÃo de melhorias na interface de um ventilador pulmonar mecÃnico de UTI segundo os princÃpios heurÃsticos.
Almgren, Birgitta. "Endotracheal Suction a Reopened Problem". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4798.
Texto completoLemoignan, Josée. "Decision-making for assisted ventilation in amyotrophic lateral sclerosis". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101862.
Texto completoJohnson, Patricia Lee y n/a. "Being At Its Most Elusive: The Experience of Long-Term Mechanical Ventilation in a Critical Care Unit". Griffith University. School of Nursing, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030926.154232.
Texto completoJohnson, Patricia Lee. "Being At Its Most Elusive: The Experience of Long-Term Mechanical Ventilation in a Critical Care Unit". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/368088.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Nursing
Full Text
Lindahl, Berit. "Möten mellan människor och teknologi : berättelser från intensivvårdssjuksköterskor och personer som ventilatorbehandlas i hemmet /". Umeå : Department of Nursing, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-495.
Texto completoSaraiva, Mateus Sasso. "Manobra de hiperinsuflação com ventilador mecânico : uma revisão sistematica com metanálise". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/159642.
Texto completoBackground: Mechanical ventilation (MV) is one of the supports used during intensive care unit admission. However, the change in the physiological mechanism of mucociliary clearance is one of the deleterious effects caused by MV and endotracheal prosthesis. Thus, respiratory physiotherapy aims to maintain the patent airways and expanded alveolar units, facilitating pulmonary ventilation and for this can be used maneuvers such as manual hyperinflation (HM) or hyperinflation with mechanical ventilator (HVM). Objective: To systematically review the effects of HVM compared with HM on the volume of depurated secretion, MV-associated pneumonia and MV time in adult patients in invasive MV; and secondarily to determine HVM effects on respiratory and hemodynamic variables. Methods: A systematic search was performed in the Cochrane CENTRAL, MEDLINE, Lilacs, PEDro and Embase databases, as well as a manual search in references of studies published up to August 2016. Randomized clinical trials (RCTs) were included, with adult patients in MV, that were submitted to the HVM maneuver comparing with HM maneuver. Two independent reviewers selected the studies, extracted data and assessed the methodological quality. Results: Of the total of 3,949 articles, three RCTs were included, totaling 96 individuals. It was observed that both interventions improved the respiratory variables: volume of secretion (0.08g, 95% CI: -0.70 to 0.85), static compliance (1.01ml / cmH2O, 95% CI: -5.80 to 7 , 83%), dynamic compliance (1.47 cmH2O, 95% CI: -3.43 to 6.36), PaO2 / FiO2 ratio (11.18; 95% CI: -26.28 to 48.65), and blood pressure Of carbon dioxide (-0.38 mmHg, 95% CI: -2.78 to 2.03), with no difference between HVM and HM. None of the included studies evaluated the variables pneumonia associated with MV and time of MV. Conclusions: This systematic review with meta-analysis has shown that both interventions improve the secretion volume, static compliance, dynamic compliance, PaO2 / FiO2 ratio and blood pressure of carbon dioxide and that there is no difference between them, however, due to limitations of the included studies, further studies are needed to confirm the findings.
Nemer, Sérgio Nogueira. "Avaliação da força muscular inspiratória (Pi Max), da atividade do centro respiratório (P 0.1) e da relação da atividade do centro respiratório/força muscular inspiratória (P 0.1 / Pi Max) sobre o desmame da ventilação mecânica". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-02082007-104326/.
Texto completoIntroduction: We hypothesized that maximal inspiratory pressure (Pi Max), airway tracheal occlusion pressure (P 0.1) and its ratio (P 0.1/Pi Max) can be used to predict weaning outcome in a mixed ICU mechanically ventilated patients. Methods: Pi Max, P 0.1 and P 0.1 / Pi Max ratio were measured in seventy consecutive intubated or tracheostomized, mechanically ventilated patients, who fulfilled weaning criteria. After these measurements of Pi Max, P0.1, respiratory rate and expiratory tidal volume (L) with the calculation of f / Vt ratio and the product P0.1x f / Vt , the patients were submitted to a spontaneous breathing trial (SBT) . Those who were able to sustain the SBT and had no need to return to mechanical ventilation in the following 24 hours were considered weaned. The sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy and Receiver- operating-characteristics (ROC) curves for this population were calculated. Results: The mean value of P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC e P 0.1 x FR /VC were 2,49 ±1,2, -34,6± 13, 0,07± 0,01, 75,4±33 and 184,6±123 respectively for the weaned patients and 4,36± 2,0, -32,1±11,0 , 0,15± 0,09, 148,4± 42 e 652,9± 358 for the not weaned patients. All the indexes distinguished between the weaned and not weaned patient, except for the Pi Max. The sensitivity for the P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC and P 0.1 x FR /VC were respectively 78,85, 65,38, 80,77, 82,69, 88,46. The specificity for P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC and P 0.1 x FR /VC were 72,2, 38,8, 72,2, 83,3, 72,2 respectively. The positive predictive value for P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC and P 0.1 x FR /VC were respectively 89,1, 75,5, 89,3, 93,4 e 90,2. The negative predictive value for P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC and P 0.1 x FR /VC were respectively 54,1, 28,0, 56,5, 62,5 e 68,4. The diagnostic accuracy for P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC and P 0.1 x FR /VC were respectively 77,1, 58,5, 78,5, 82,8 e 84,2. The area under the ROC curves for P 0.1 , Pi Max, P 0.1 / Pi Max, FR / VC and P 0.1 x FR /VC were respectively 0,76± 0,06, 0,52±0,08 , 0,78±0,06, 0,90±0,04 e 0,84±0,05. The comparison among the areas under the ROC curves showed that the best weaning indexes were f / Vt ratio, the product P 0.1 x f / Vt and the P0.1/ Pi Max ratio with no statistic differences among them. The Pi Max presented the smaller area under the ROC curve. The weaning indexes P 0.1, Pi Max e P 0.1/ Pi Max were not statistically different between intubated or tracheostomized patients. Conclusion: The best weaning indexes were f/Vt ratio , the product P 0.1 x f/Vt and the P 0.1 / Pi Max ratio with no statistically difference among them.
Nakamura, Maria Aparecida Miyuki. "Desempenho dos ventiladores convencionais em ventilação não invasiva: impacto da máscara total face® em modelo mecânico". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-29012009-111311/.
Texto completoBACKGROUND: The success of therapy with noninvasive ventilation with positive pressure (VNIPP) is associated with interface choice. The Total face® mask (TFM) is an interface considered more comfortable than other, but it has a large dead space (875 ml) and constant high leakage. However, intensive care ventilators have been usually used for noninvasive ventilation in the ICU environment, their ability to operate with high air leakage is not known. OBJECTIVES: To evaluate the performance of nine ICU ventilators using TFM and compare them with a VNIPP mode only ventilator (Respironics BiPAP Vision). METHODS: a mechanical respiratory system simulator with two compartments was adapted to TFM what was connected to tested ventilators. The inspiratory effort was simulated using pressure control mode in Newport E500 ventilator. The ventilators were tested in spontaneous mode being adjusted at two values of PEEP (5 and 10cmH2O) and 3 values of pressure support (5, 10 and 15 cmH2O). It was tested if ventilators worked properly with TFM and its performance to compensation for leakage, its pressurization, the capability to reach peak flow target, and trigger and cycling delays. RESULTS: The Vision ventilator worked properly in all situations. Four conventional ventilators (Horus, Vela, E500 and Servo) worked. The main problem with failed ventilator was auto triggering and inspiratory flow turning off. Among worked ventilators, peak inspiratory leakage average was greater than 1L / s , generated peak flow reached maximum capacity in some settings with NIV mode only ventilator. The ability to compensate for leak was variable between ventilators, but those with greater difficulty (E500 and Horus) maintained the lowest values of PEEP and also had great trigger delays, the other ventilators showed trigger delays smaller than 100ms. The cycling occurred by security criteria on Horus, Vela and E500 ventilators in some settings. The ability of pressurization was evaluated by calculating the PTP with 500ms and 1 second. The area of pressurization with 1 second remained below 50% of target area for all ventilators, including for Vision, specifically for VNIPP. Horus ventilator has the worst pressurization performance. CONCLUSIONS: Among nine conventional tested ventilators, only four worked with the TFM. The performance among the ventilators was variable; as a result some of them were not suitable for use with NIV using TFM. The greatest difficulty for conventional ventilator operation was dealing with the large leakage, occurring auto triggering or inspiratory flow turning off, alarming disconnection. The air leakage through the mask holes (exhalation port) was high. Horus and E500 ventilators had trigger delays greater than 100ms and cycling occurred by security criteria for all conventional ventilators, except the Servo, in some setting
Couto, Lara Poletto. "Estudo do funcionamento da ventilação assistida proporcional plus em um sistema pulmonar mecânico". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-25102012-164038/.
Texto completoBACKGROUND: Proportional assist ventilation plus (PAV+) is a new concept of assist ventilatory support conceived to act according to the levels of inspiratory efforts, respiratory mechanics and percentages levels of assistance. This complex interaction among the factors commanding its function is difficult to detect in clinical setting. This study aimed to provoke changes in compliance, resistance and inspiratory efforts in a lung simulator to understand the responses of PAV+ support. METHODS: In the Mechanical Ventilation Laboratory at University of São Paulo, an Inter Plus ventilator (Intermed ®) connected to lung simulator (Michigan Instruments Inc) acted triggering Puritan-Bennett 840 ventilator (Covidien ®) at different levels of inspiratory efforts. Expiratory tidal volumes were measured and compared (ANOVA-2-way) at 10 levels of PAV+ support (from 5% to 95%), 3 levels of lung simulator compliance (50, 100, 150 mL/cmH20), 3 levels of airway resistance (5, 20, 50 cmH20/L/s) and 4 levels of inspiratory effort ( -2, -5, -8, -15 cmH20). RESULTS: A total of 360 tidal volumes were measured. They increased significantly during increment of inspiratory efforts and during higher inspiratory efforts with higher compliances. They decreased significantly during respiratory resistance increments, especially when combined with low inspiratory efforts and compliances. Runaway occurred during PAV+ support of 95% combined with high respiratory resistance and compliance. CONCLUSIONS: PAV+ responded adequately to provoked changes in the tested respiratory compliances and inspiratory efforts. It responded to very high resistance only when associated with high inspiratory efforts. There was no runaway phenomenon during PAV+ assistance below 95%.
Elshafie, Ghazi Abdelgadir E. "Ventilatory mechanics in thoracic surgery". Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7141/.
Texto completoYoung, Peter Jeffrey. "Pulmonary aspiration in mechanical ventilation". Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323263.
Texto completoPowelson, Stephen K. (Stephen Kirby). "Design and prototyping of a low-cost portable mechanical ventilator". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59954.
Texto completoCataloged from PDF version of thesis.
Includes bibliographical references (p. [10]).
This paper describes the design and prototyping of a low-cost portable mechanical ventilator for use in mass casualty cases and resource-poor environments. The ventilator delivers breaths by compressing a conventional bag-valve mask (BVM) with a pivoting cam arm, eliminating the need for a human operator for the BVM. An initial prototype was built out of acrylic, measuring 11.25 x 6.7 x 8 inches (285 x 170 x 200 mm) and weighing 9 lbs (4.1 kg). It is driven by a stepper motor powered by a 14.8 VDC battery and features an adjustable tidal volume of up to 900 mL, adjustable breaths per minute (bpm) of 5-30, and inhalation to exhalation time ratio (i:e ratio) options of 1:2, 1:3 and 1:4. Tidal volume, breaths per minute and i:e ratio are set via user-friendly knobs, and the settings are displayed on an LCD screen. The prototype also features an assist-control mode and an alarm to indicate over-pressurization of the system. Future iterations of the device will be fully calibrated to medical standards and include all desired ventilator features. Future iterations will be further optimised for low power-consumption and will be designed for manufacture and assembly. With a prototyping cost of only $420, the bulk-manufacturing price for the ventilator is estimated to be less than $100. Through this prototype, the strategy of cam-actuated BVM compression is proven to be a viable option to achieve low-cost, low-power portable ventilator technology that provides essential ventilator features at a fraction of the cost of existing technology. Keywords: Ventilator, Bag Valve Mask (BVM), Low-Cost, Low-Power, Portable and Automatic.
by Stephen K. Powelson.
S.B.
Sperber, Jesper. "Protective Mechanical Ventilation in Inflammatory and Ventilator-Associated Pneumonia Models". Doctoral thesis, Uppsala universitet, Infektionssjukdomar, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282602.
Texto completoGrano, Joan. "Ventilator-Associated Complications in the Mechanically Ventilated Veteran". Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5749.
Texto completoPh.D.
Doctorate
Nursing
Nursing
Nursing
Lyazidi, Aissam. "Évaluation des performances et des limitations des ventilateurs sur banc d'essai". Thesis, Paris Est, 2010. http://www.theses.fr/2010PEST1073.
Texto completoThe ventilators have markedly improved thanks to progress in respiratory physiology, in informatics and miniaturization. However, their intrinsic performances remain unequal. The aim was to evaluate ventilators performances on reproducible bench test studies adapted to clinical questions. Tests show that 1) the error of really delivered volume is approximately 1 ml/kg of additional volume; the tidal volume (VT) indicated on the ventilators was lower than the real delivered VT ; 2) Performances of new ventilators are comparable to the best ventilators tested in 2000 ; turbine ventilators are quite similar to best conventional ventilators ; 3) The ventilators dedicated to non invasive ventilation showed better performances to cope with leaks 4) The intrapulmonary percussive ventilation superimposed on conventional ventilation can reduce humidity, increase volumes and can generate intrinsic positive expiratory pressure. The bench tests showed a large heterogeneity of performances. A technological watch seems essential to evaluate all new ventilators
Balaji, Ravishankar. "Breathing Entrainment and Mechanical Ventilation in Rats". Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307743446.
Texto completoMortimer, A. J. "High frequency jet ventilation : Mechanics and gas exchange". Thesis, University of Newcastle Upon Tyne, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373490.
Texto completoClochesy, John Michael. "Factors influencing weaning adults from long-term positive pressure mechanical ventilatory support". Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057080137.
Texto completoCoisel, Yannaël. "Ventilation mécanique en anesthésie réanimation : évaluation des nouveaux modes ventilatoires en médecine péri-opératoire". Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T011/document.
Texto completoIn case of respiratory failure, the patient's respiratory muscles are put at rest. The patient is then linked to an artificial ventilator, which makes him breath. There are a huge number of artificial ventilators, of varying quality, and each device offers many different settings : the ventilatory modes. These devices and their ventilatory modes are marketed and used daily, but few of them have ever been evaluated in a clinical situation and their performances still need to be proven. Interactions between these ventilatory modes and respiratory muscles are presently unknown. In this work, we first made an inventory of mechanical ventilation in peri-operative medicine (patients in operating rooms and in intensive care units). Then, we evaluated on a bench test the technical performances of the latest generation of anesthesia and intensive care ventilators, in static conditions (controlled ventilation in different pathologic pulmonary conditions) and in dynamic conditions (assisted spontaneous breathing in different weaning situations), and we established criteria to check before choosing a ventilator. Third, we analysed the behaviour of several advanced ventilatory modes (Neurally Adjusted Ventilatory Assist (NAVA), Proportional Assist Ventilation Plus (PAV+), Adaptive Support Ventilation (ASV), Intellivent, Noisy-PSV) during ventilator weaning of intensive care patients compared to the reference weaning mode : Pressure Support Ventilation. Finally, we present research perspectives and potential benefits from our studies through our experimental and clinical project
Kolandaivelu, Kumaran. "Development of a miniature high frequency ventilator for genetically engineered newborn mice". Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/60745.
Texto completoKilander, Johanna y Madeleine Frisell. "Variable expiration control for an intensive care ventilator". Thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-157761.
Texto completoYuta, Toshinori. "Minimal Model of Lung Mechanics for Optimising Ventilator Therapy in Critical Care". Thesis, University of Canterbury. Mechanical Engineering, 2007. http://hdl.handle.net/10092/1608.
Texto completoArief, Nyimas. "Automated Detection of Incomplete Exhalation as an Indirect Detection of Auto-PEEP on Mechanically Ventilated Adults". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/534.
Texto completoJúnior, Marcus Henrique Victor. "Implementation and assessment of a novel mechanical ventilatory system following a noisy ventilation regime". Instituto Tecnológico de Aeronáutica, 2014. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=3151.
Texto completoKoombua, Kittisak. "Multiscale Modeling of Airway Inflammation Induced by Mechanical Ventilation". VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1841.
Texto completoYeung, Mei-yan y 楊美恩. "Evidence-based guidelines on ventilator-associated pneumonia prevention for mechanically ventilated patients". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44626885.
Texto completoParotto, Matteo. "Studio dei meccanismi coinvolti nel "ventilator-induced lung injury"". Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422171.
Texto completoIntroduzione. La ventilazione meccanica (MV) ha rappresentato un fondamentale passo avanti nell’assistenza dei pazienti sia in terapia intensiva sia in anestesia. Purtroppo però essa può esacerbare, o addirittura iniziare, un danno polmonare acuto. Molti pazienti con Acute Respiratory Distress Sindrome (ARDS) ventilati meccanicamente sviluppano fibrosi polmonare. Abbiamo ipotizzato che la MV possa contribuire mediante diversi meccanismi allo sviluppo di tale fibrosi. Materiali e metodi. In vitro. Cellule epiteliali alveolari umane BEAS-2B sono state sottoposte ad allungamento meccanico ciclico per 24 o 48 ore, e quindi si è analizzata l’espressione di marcatori epiteliali e mesenchimali in esse. In vivo. Topi C57 Bl/6 sono stati randomizzati verso 4 trattamenti: controlli sani; inalazione di acido cloridrico (HCl); inalazione di soluzione di controllo seguita dopo 24 ore da MV; inalazione di HCl seguita dopo 24 ore da MV. Gli animali trattati sono stati quindi seguiti per periodi di 3, 8 e 15 giorni dopo l’inalazione. Si sono analizzate le meccaniche polmonari, l’istologia polmonare, i fibrociti circolanti, i quantitativi di idrossiprolina così come l’espressione di marcatori epiteliali e mesenchimali nei polmoni. Risultati. In vitro. L’allungamento meccanico ciclico ha determinato nelle cellule BEAS-2B una riduzione nell’espressione dei marcatori epiteliali citocheratina 8, E-caderina e pro-proteina del surfattante B (proSPB), ed un aumento dell’espressione di TGF-β1 e β-catenina e dei marcatori mesenchimali α-SMA e vimentina A. In vivo. La MV, da sola o in associazione all’inalazione di HCl, ha determinato alterate meccaniche polmonari, un aumento del contenuto di idrossiprolina e dell’espressione di TGF-β1 e β-catenina e dei marcatori mesenchimali α-SMA e vimentina A, ed una diminuita espressione dei marcatori epiteliali citocheratina 8, E-caderina e proSPB. I fibrociti circolanti non sono stati influenzati dalla MV. L’istologia polmonare ha mostrato aumentata fibrosi negli animali trattati e potenziale transizione epitelio-mesenchimale dopo inalazione di HCl seguita da MV. Conclusioni. Lo stress meccanico determina fibrosi polmonare, e il fenomeno della transizione epitelio-mesenchimale potrebbe giocare un ruolo in questo processo. Se i risultati del nostro lavoro saranno confermati, la modulazione della risposta fibrotica nei pazienti che necessitano di MV potrebbe rappresentare un nuovo, importante bersaglio terapeutico da investigare.
Liu, Hui. "The application of alveolar microscope on alveolar mechanics of ventilator-induced lung injury". [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-61847.
Texto completoHedberg, Malin y Roodsari Leila Tavallaey. ""Gör som ni brukar" : Intensivvårdssjuksköterskors uppfattning om urträning från ventilator". Thesis, Röda Korsets Högskola, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-671.
Texto completoBackground: Weaning onset should be initiated when the patient´s condition permits it, too early or late onset can have negative consequences for the patient. To help the nurse perform weaning, tools such as evidence-based weaning protocols have been developed and results in more consistent treatment shown to shortening duration of ventilator treatment. Differences between health profession, i.e. educational level, experience, responsibilities and organization structure, affect how the weaning is performed. Objective: To describe ICU nurses´ perception of ventilator weaning. Method: An empirical focus group study with a qualitative and descriptive approach was conducted. Six intensive care nurses were included. Data was analyzed using content analysis. Results: Three main categories were revealed, the Organization, the Intensive care nurse and the Patient along with four subcategories, Procedures, Collaboration, Competence and Nursing. Conclusion: For the weaning process to work satisfactorily a clear structure is needed. This can be created with routines, effective collaboration, clear communication and tools such as weaning protocols. For the patients weaning would be facilitated, become more efficient and shorten the duration of treatment. Clinical significance: The study may contribute to the discussion about the conditions needed to conduct effective weaning based on good and reliable evidence-based care. These conditions may contribute to increase patient safety, shorter hospital stay and lower health care costs.
Carteaux, Guillaume. "Optimisation des interactions patient-ventilateur en ventilation assistée : intérêt des nouveaux algorithmes de ventilation". Thesis, Paris Est, 2015. http://www.theses.fr/2015PESC0027/document.
Texto completoDuring assisted mechanical ventilation, patient-ventilator interactions, which are associated with outcome, partly depend on ventilation algorithms.Objectives: : 1) during invasive mechanical ventilation, two modes offered real innovations and we wanted to assess whether the assistance could be customized depending on the patient's respiratory effort during proportional ventilatory modes: proportional assist ventilation with load-adjustable gain factors (PAV+) and neurally adjusted ventilator assist (NAVA); 2) during noninvasive ventilation (NIV): to assess whether NIV algorithms implemented on ICU and dedicated NIV ventilators decrease the incidence of patient-ventilator asynchrony.Methods: 1) In PAV+ we described a way to calculate the muscle pressure value from the values of both the gain adjusted by the clinician and the airway pressure. We then assessed the clinical feasibility of adjusting the gain with the goal of maintaining the muscle pressure within a normal range. 2) We compared titration of assistance between neurally adjusted ventilator assist (NAVA) and pressure support ventilation (PSV) based on respiratory effort indices. During NIV, we assessed the incidence of patient-ventilator asynchrony with and without the use of NIV algorithms: 1) using a bench model; 2) and in the clinical settings.Results: During PAV+, adjusting the gain with the goal of targeting a normal range of respiratory effort was feasible, simple, and most often sufficient to ventilate patients from the onset of partial ventilatory support until extubation. During NAVA, the analysis of respiratory effort indices allowed us to precise the boundaries within which the NAVA level should be adjusted and to compare patient-ventilator interactions with PSV within similar ranges of assistance. During NIV, our data stressed the heterogeneity of NIV algorithms implemented on ICU ventilators. We therefore reported that dedicated NIV ventilators allowed better patient-ventilator synchronization than ICU ventilators, even with their NIV algorithms engaged.Conclusions: During invasive mechanical ventilation, customizing the assistance during proportional ventilatory modes with the goal of targeting a normal range of respiratory effort optimizes patient-ventilator interactions and is feasible with PAV+. During NIV, dedicated NIV ventilators allow better patient-ventilator synchrony than ICU ventilators, even with their NIV algorithm engaged. ICU ventilators' NIV algorithms efficiency is however highly variable among ventilators
Carroll, Nadine. "The use of protriptyline or nocturnal mechanical ventilatory support for respiratory failure in chronic bronchitis and emphysema". Thesis, University of Liverpool, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235493.
Texto completoPUTIGNANO, OSCAR. "Development of a Cherenkov based diagnostic for gamma-rays from fusion plasmas and advanced medical applications". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/402358.
Texto completoAim of this thesis, begun in November 2019, is the development of an innovative Cerenkov detector for measurements of 17 MeV gamma-rays emitted by the D-T fusion reaction in an intense neutron field. With the spread of the COVID-19 pandemics in Northern Italy in February 2020, it became clear that the original program planned for my PhD work had to be significantly changed, since experimental activities to be carried out in the UNIMIB/CNR laboratories in Milan and at the Joint European Torus in the UK had to be cancelled. In agreement with my tutors I volunteered together with other scientists to contribute to a project called Mechanical Ventilator Milan (MVM). The MVM project involved an international team of more than 150 scientists and has produced over the very short period of less than three months a mechanical ventilator approved by the American Food and Drug Administration for use at the intensive care unit of hospitals to treat patients affected by COVID-19. The activities of the MVM project led to the development of a new fast oxygen sensor for medical application, about one year later. The sensor measures the oxygen consumption in real time during a single breath. The thesis is organized in three parts. The first part is focused on the development of a gamma-ray counter optimized for the measurement of the D-T fusion power produced in a magnetic confinement fusion device. The research team I have joined is developing a novel technique for the measurement of DT fusion power in a magnetic confinement device based on the detection of 17 MeV gamma-rays also produced by the D+T->5He* reaction. The 5He* nucleus promptly decays usually emitting an alpha particle and a neutron, but it may de-excite to the ground level emitting a gamma-ray with a probability of the order of 10^-5. These gamma-rays have been detected in the recent DT campaign at JET with a gamma spectrometer based on LaBr3 and a fast digital data acquisition. Since the efficiency of the scintillator to high energy gamma-rays and neutrons are comparable, the use of a dedicated LiH based neutron attenuator to observe the weak gamma-ray signal is needed. To overcome the limitations posed by the sensitivity of LaBr3 detectors to neutrons, I designed a gamma-ray gas detector optimized to work in the presence of an intense neutron field. The detector is based on the Cherenkov effect and simulations indicate that it is 10^6 times more sensitive to gamma-rays than to neutrons. The next step would be to build a prototype of the detector to validate the simulation results and to test it on a D-T neutron source. The second part of the thesis describes the design and build of the IFOx sensor, an ultra-fast oxygen sensor that can be used for lung analysis by working in the so called mainstream configuration. Since the working principle of the IFOx sensor somewhat resembles the one of a scintillator detector, this is an example of knowledge transfer from nuclear diagnostics to a different application. The prototype that was built features excellence time response and was used in a trial study on healthy volunteers to measure the Functional Residual Capacity. The excellent results of the trial study on healthy volunteers has opened up the possibility to carry out a clinical study on intensive care unit patients in the near future, by integrating the oxygen sensor with mechanical ventilators. The last part of the thesis is about the MVM project and describes the ventilator design aimed to the production of a ventilator composed of a few parts so that it can be rapidly built on large scales even during the disruption of the components supply chain. I was able to contribute to the project thanks to my knowledge of gas systems, advanced real time controls, and I participated in the measurement required for the certification. The key results that led to a full certification for usage on patient by the European Commission are also described in this work.
Baudin, Florent. "Ventilation mécanique dans les pathologies obstructives de l'enfant : physiopathologie des interventions ventilatoires et non ventilatoires". Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1056/document.
Texto completoObstructive lung disease in children (asthma and bronchiolitis) are one of the main causes of admission to pediatric intensive care units. For several years, progress has been made to reduce the invasiveness of care resulting in a decrease in associated morbidity. The main objective of the thesis was to propose new ventilatory and non-ventilatory strategies based on physiopathology to optimize the care of such children.In children with severe bronchiolitis we evaluated the impact of prone position associated with non-invasive ventilation. The prone position decreases significantly the inspiratory work of breathing and improves the neuromechanical efficiency of the diaphragm. We also evaluated the effect of neurally adjusted ventilatory assist (NAVA) that is a proportional ventilatory mode based on the electrical activity of the diaphragm. We demonstrated that NAVA improved the patient-ventilator interactions and decrease the work of breathing in comparison with nasal continuous positive airway pressure (nCPAP). We also evaluated the feasibility of high flow nasal cannula as a respiratory support in children with severe asthma attack. These strategies need now to be validated on clinical outcomes and are the subject of two ongoing multicenter randomized trials
Turowski, Paweł [Verfasser]. "Molecular mechanisms of ventilator-induced acute kidney injury : Mechanical ventilation can modulate neutrophil recruitment to the kidney / Paweł Turowski". Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064838820/34.
Texto completoHerbert, Joseph Ames. "The molecular and mechanical mechanisms of the age-associated increase in the severity of experimental ventilator induced lung injury". VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4478.
Texto completoLattuada, Marco. "Effect of Ventilatory Support on Abdominal Fluid Balance in a Sepsis Model". Doctoral thesis, Uppsala universitet, Klinisk fysiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207218.
Texto completoMacDonald, Ian. "Burial mechanics of the Pacific sandfish| The role of the ventilatory pump and physical constraints on the behavior". Thesis, Northern Arizona University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10004157.
Texto completoBurial is an important life history strategy employed by benthic fishes that has not been fully explored in its diversity by the biomechanical literature. This thesis explores the mechanism by which the Pacific sandfish buries as well as the physical limitations of the behavior. We first investigate the role of the ventilatory pump in the burial behavior of sandfish by using high-speed videography, dye, and digital particle image velocimetry (DPIV). We determined that sandfish employ a modification of the ventilatory pump, which is used repeatedly to fluidize the substrate ventral to the head. This modification of the ventilatory pump should reduce the energetic costs associated with burial as it decreases the cost of transport typically associated with ‘shoveling’ substrate. Second, we investigate the physical limitations that are caused by the reliance on the ventilatory pump to fluidize substrate. We used sand beds of varying grain sizes, and therefore varied the minimum velocities of fluidization, to determine how sandfish respond variation in substrata. We determined that sandfish can bury in grains smaller than 1.00mm in diameter but were unable to bury in any substrate larger than 1.00mm. We also determined that there was an increase in the time it took sandfish to bury in those substrates smaller than 1.00mm as grain size increased. There was no change in the frequency of the behavior, however, suggesting that sandfish have very little ability to bury in larger substrates. We also determined that it is probably not the absolute velocity produced by the opercular jet that determines burial success, but the ability burying behavior to maintain the sand’s momentum during the expansive phase that occurs between bouts of opercular jetting.
Micski, Erik y Ulrika Ottosson. "Calculation of Tidal Volume based on EMG-activity of the Diaphragm". Thesis, KTH, Skolan för teknik och hälsa (STH), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210547.
Texto completoSilva, Alexandre Rodrigues da. "Hardware de ventilador pulmonar". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/3/3139/tde-03052012-121527/.
Texto completoThis work aimed to present the development of a pulmonary mechanical ventilator, mainly focusing on the hardware part needed in order for this device to work. Mechanical ventilation is the most important medical mode concerning the care of patients that are critically ill. The ventilator is a device very much used in intensive care units (ICUs), and it basically delivers an air and oxygen mixture to the patients lungs that is normally unable to do so naturally, either because the patient is seriously ill that prevents him/her to do so, or due to surgery, in this case prevented the movement of the diaphragm muscle so the air could be naturally delivered to the lung. This work covered a comprehensive description about this ventilator, its transformation of compressed air and oxygen coming from a cylinder in a controlled mixture of flows that enters the lung for the inspiration of a volume, or to achieve a determined pressure, and the output of this mixture, maintaining a controlled pressure in the lung too. A hardware and firmware prototype was developed for this device. The aim was to show the transformation process from the main idea and the need for a project of a tested and certified device to be used in the market.
Mercene, Tedgardo Pacal. "Improving Quality of Care for Mechanically Ventilated Patients in Long Term Care Through Full Compliance with the Ventilator Bundle Protocol". ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2853.
Texto completoHarvey, Jessica C. "The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial". University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125476.
Texto completoMarjanovic, Nicolas. "Approche globale du support ventilatoire en médecine d'urgence". Thesis, Poitiers, 2020. http://theses.univ-poitiers.fr/64158/2020-Marjanovic-Nicolas-These.
Texto completoAcute respiratory failure is a common complaint of patients visiting the Emergency Department and conventional oxygen therapy is its first-line treatment. Ventilatory support is required when nasal oxygen therapy is not enough or as a first-line treatment in the most severe cases. Ventilatory supports include high-flow and humidified nasal cannula oxygen (HNFO) and mechanical ventilation. Data assessing their values in Emergency Departments (EDs) mainly come from research conducted in Intensive Care Units. In addition, a comprehensive approach of their application and their results in Emergency Departments has never been conducted.The aim of this research is to provide a comprehensive assessment of ventilatory supports in EDs by assessing the place of HFNO, introducing recently in this setting, and the practice of noninvasive and invasive mechanical ventilation in EDs. We assessed first the clinical and biological impact of HFNO in patients admitting to an ED for de novo acute hypoxemic respiratory failure, then in patients admitting for acute hypercapnic respiratory failure secondary to acute heart failure, through two prospective studies. In addition, we provided a matching of data issued from all prospective trials conducted in the EDs. We aimed to determine if early application of HFNO in patients with acute respiratory failure improves outcome. We found HFNO applied early was associated with an improvement in clinical and biological patterns in patients admitted for de novo acute hypoxemic respiratory failure, and similarly in patients admitted for acute hypercapnic respiratory failure due to acute heart failure. However, HFNO was not associated with a reduction of mechanical ventilation requirements or in mortality. In addition, we assessed mechanical ventilation in the ED by analysing three determinants that may influence patient’s outcome. First, we conducted a large bench test assessing performance and usability of all emergency ventilators marketed in Europe or North America and assessing through two distinct studies. Then, we assessed the mechanical ventilation practice in six French EDs and measured the association between mechanical ventilation settings and patients’ outcome. Performance of recent emergency ventilator were closes to ICU ventilators due to high technological improvements in the last decades. These improvements were associated with an increase of their complexity without impairment of their usability. Finally, in six French EDs, most of the patients were treated with a low tidal volume (between 6 and 8 mL/kg of predicted body weight) as recommend by scientific societies. However, a low tidal volume strategy was not associated with a reduction in the acute respiratory distress incidence as well as in mortality. These studies provided a comprehensive assessment of the ventilator support in the ED, including invasive and noninvasive ventilation, through a clinical and technological approach, and an emerging treatment, HFNO, by its clinical, biological and prognostic impact
Aguirre, Bermeo Hernán Marcelo. "Efectos fisiológicos de diferentes estrategias ventilatorias empleadas en pacientes con insuficiencia respiratoria aguda severa". Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664280.
Texto completoThe studies described in this thesis are about the physiological effects of two common strategies that are used in mechanically ventilated patients with acute severe respiratory failure. The first study was about the prolongation of inspiratory pause. This study confirmed that the prolongation of inspiratory pause significantly decreased dead space and PaCO2. Indeed, this study provides a clinical application of this strategy, because the decrease of the PaCO2 allows a significant decrease of tidal volume and helps to set the protective ventilation. The second study analysed the variation of lung volumes and strain with the change from supine position to prone position. This study showed a significant increase in lung volumes and a significant decrease of strain in prone position. These findings could explain the improvement of outcomes with prone position in severe acute respiratory distress syndrome patients. The relative simplicity and safety of these strategies facilitates its application at the bedside. These data could form the basis for future studies in other types of patients and pathologies.
Pastore, C. V. "VENTILAZIONE MECCANICA E VOLUTRAUMA: STUDIO IN VIVO IN UN MODELLO SUINO". Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150177.
Texto completoRozé, Hadrien. "Activité électrique diaphragmatique au cours du sevrage ventilatoire après insuffisance respiratoire aigue". Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0293/document.
Texto completoThe control of breathing results from a complex interaction involving differentrespiratory centers, which feed signals to a central control mechanism that, in turn, provides outputto the effector muscles. Afferent inputs arising from chemo- and mechanoreceptors, related to thephysical status of the respiratory system and to the activation of the respiratory muscles, modulatepermanently the respiratory command to adapt ventilation to the needs. Diaphragm electricalactivation provides information about respiratory drive, respiratory muscle loading, patientventilatorsynchrony and efficiency of breathing in critically ill patients. The use of inappropriatelevel of assist during spontaneous breathing with over or under assist might be harmful withdiaphragmatic dysfunction, alveolar injury and asynchrony. The first study settled NAVA modeaccording to the EAdi recorded during a failed spontaneous breathing trial (SBT). An unexpecteddaily increase of EAdi has been found during SBT until extubation. The second study did not findany increase of the neuroventilatory efficiency during weaning, possibly because of residualsedation. A third study described the inhibition of residual sedation on EAdi and tidal volume at thebeginning of the weaning, and the correlation between them. The last study did not find anyincrease of tidal volume under NAVA after lung transplantation, with denervated lung withoutHerring Breuer reflex, compared to a control group. Moreover tidal volume under NAVA wascorrelated to total lung capacity. These studies highlight the interest of EAdi monitoring duringweaning
Amorim, Raquel Margarida da Cruz. "O Desmame Precoce da Pessoa submetida a Ventilação Mecânica Invasiva: O Impacto das Intervenções de Enfermagem de Reabilitação". Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Saúde, 2019. http://hdl.handle.net/10400.26/29374.
Texto completoA Ventilação Mecânica Invasiva é reconhecida como processo terapêutico adjuvante à pessoa acometida de insuficiência respiratória. Em correlação com os seus benefícios, existe a probabilidade de ocorrência de complicações a nível respiratório e motor. Neste contexto, é realçada a importância de realizar um desmame ventilatório precoce. A eficácia e eficiência do desmame ventilatório, requerem do Enfermeiro Especialista em Enfermagem de Reabilitação as competências para elaborar, desenvolver e implementar um plano de intervenção individual, baseado numa avaliação criteriosa do doente. Este relatório surge no decurso da análise ao processo de aquisição e sedimentação de competências comuns do Enfermeiro Especialista, específicas em Enfermagem de Reabilitação, bem como a obtenção de competências de mestre. Este processo foi realizado através das várias fases do plano de intervenção aplicado ao doente submetido a Ventilação Mecânica Invasiva, com o objetivo de desenvolver competências científicas, técnicas e humanas especializadas, ao longo do processo de desmame ventilatório.
Mechanical Invasive Ventilation is recognized as an adjuvant therapeutic process for the person suffering from respiratory failure. In correlation with its benefits, there is a probability of respiratory and motor complications. In this context, the importance of early weaning is emphasized. The efficacy and efficiency of ventilatory weaning require the Nurse Specialist in Rehabilitation Nursing the skills to design, develop and implement an individual intervention plan, based on a careful evaluation of the patient. This report arises during the analysis of the process of acquisition and solidification of common competences of the Specialist Nurse, specific in Rehabilitation Nursing, as well as the acquisition of master's competences. This process was carried out through the various phases of the intervention plan applied to the patient submitted to Mechanical Invasive Ventilation, with the objective of developing specialized scientific, technical and human skills throughout the ventilatory weaning process.
Craven, Thomas Henry John. "Resolving uncertainty in acute respiratory illness using optical molecular imaging". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29507.
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