Tesis sobre el tema "Mannose"
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Pallanca, Jane Emma. "The chemo-enzymic synthesis of GDP-mannose and GDP-mannose analogues". Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294003.
Texto completoJAZIRI, NOUREDDINE. "Analogues de gdp-mannose : inhibiteurs potentiels de la gdp-mannose deshydrogenase". Paris 6, 1992. http://www.theses.fr/1992PA066661.
Texto completoTailford, Louise Elizabeth. "Catalytic recognition of mannose". Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437254.
Texto completoMba, Mintsa Léa. "Synthèse et évaluation angiogénique d'analogues du M6P". Thesis, Montpellier, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCM0028.
Texto completoAngiogenesis is the protector of vascular integrity, through the formation of new blood vessels from pre-existing vessels. The angiogenesis is regulated by the angiogenic factors. Several stimuli are involved in the angiogenic balance’s destabilization, which produces an unusual vascularization. The interest of conventional and targeted therapies is to restore a normal vascularization, by targeting all the factors which are involved in the angiogenic process. It has been demonstrated that the CI-M6PR is involved in this mechanism. This receptor has the distinction of having more binding sites, so a variety of ligands, including the M6P and its analogs. During this study we want to know if the M6P, isostere analog of M6P, interacts with the CI-M6PR. For this, we reappropriated the assay CAM, slightly modified, to confirm at first the pro-angiogenic activity of M6A. In a second step we will use the flow cytometry technique to highlight the interaction between the M6A and CI- M6PR
Castilla, López Javier. "Carbohydrate manipulations towards high-mannose oligosaccharides". Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/87113.
Texto completoThe final goal of this thesis is the development of strategic methods fro the synthesis of well-defined 1,2-linked oligosaccharides and S-linked thio-analogues through different polymerization techniques. These structures form a complex group of biomolecules with an unsurpassed structural diversity, performing a variety of biological functions. In this context, the present work aimed to develop new procedures in carbohydrate chemistry, focusing in the oligomerization reactions. Thus, efficient syntheses have been studied for accessing the suitable carbohydrate based monomers (including epoxides, episulfides, carbonates and tiocarbonates). Unexpectedly, the synthesis of epithiocarbohydrates afforded carbohydrate-derived 1,3-oxazolidine-2-thiones. These compounds have proved to be quite attractive as new enzyme inhibitors for Gaucher disease. All enzyme inhibition studies can be found in the manuscript.
Gazi, Umut. "The mannose receptor in macrophage biology". Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11587/.
Texto completoWilliams, Paula Mary. "Studies towards the chemo-enzymatic synthesis of carba-GDP-mannose; A mannosyl transferase donor substrate analogue". Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534664.
Texto completoVidil, Carole. "Synthèses et évaluations biologiques de phosphonates analogues du mannose 6-phosphate, substrats potentiels du récepteur mannose 6-phosphate". Montpellier 2, 1997. http://www.theses.fr/1997MON20247.
Texto completoNapper, Catherine E. "Functional analysis of the macrophage mannose receptor". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249560.
Texto completoChavele, Konstantia-Marie. "The role of Mannose receptor in glomerul". Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508459.
Texto completoJeanjean, Audrey. "Ciblage du récepteur mannose 6-phosphate cation indépendant par des ligands, monovalents ou bivalents, analogues du mannose 6-phosphate". Montpellier 2, 2005. http://www.theses.fr/2005MON20067.
Texto completoFrancois-Heude, Marc. "Mimes de Haut-Mannoses : synthèse, caractérisation et reconnaissance par les lectines". Amiens, 2014. http://www.theses.fr/2014AMIE0100.
Texto completoHigh-mannoses are natural N-glycan type oligomannoses which are covalently linked to definite proteins and are involved in diverse biological mechanisms. Their synthesis remains difficult and expensive, and the quantities obtained do not allow considering a large scale-up for therapeutic applications. The cheaper and faster mimic production can thus be seen as an alternative. The goal of our mimic (pseudo oligomannose) synthesis strategy is to conserve as much as possible the tridimensional features of natural High-mannoses. It is based on the substitution of the three internal mannose residues by 1,2,3 triazole units allowing the addition of six mannoses/pseudo-mannoses terminal residues in a single 1,3 dipolar cycloaddition step. A mimic library has been generated including the low molecular weight PMan3 (pseudo tri-mannose), PMan4 and PMan5 analogues. In a similar manner the PMan8 and PMan9 have been synthetized at the 100 mg scale. Biochemical ELLA assays using either the Concanavalin A (Con A) or the human macrophage lectin (rhMMR) have shown very similar IC50 values between the natural Man9 and its PMan9 mimic (3 and 7,1 M by using Con A, and 4 et 5,5 M by using rhMMR respectively). The dissociation constants of natural High-mannoses toward Con A have been determined by mass spectrometry and the same analyses are on-going for their mimic counterparts. Moreover, the crystal structure of the PMan9/Con A complex has been resolved and has shown that the terminal mannoses are recognized in a similar manner as the natural oligomannoses. Altogether, our results confirmed that our synthesis strategy leads easily to the production of high-mannose mimics whose biochemical and structural features are closed to their natural counterparts
Carpenter, Chrissie Ann. "Mannaric acid and mannaric acid polyamides synthesis and characterization /". CONNECT TO THIS TITLE ONLINE, 2008. http://etd.lib.umt.edu/theses/available/etd-12112008-141014/.
Texto completoCombemale, Stéphanie. "Nano-objets mannosylés et nouveaux analogues du M6P : application à l'angiogenèse". Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20081.
Texto completoIn 1971, the American Dr. Judah Folkman published the hypothesis : tumor growth depends on angiogenesis. The challenge of current research is to find a way to starve tumors by inhibiting angiogenesis. Angiogenesis is a complex physiological process that involves many receptors, among which is the receptor for mannose-6-phosphate / Insulin-like growth factor II (RM6P/IGF-II). The aim of this work was the synthesis of mannosyl nano-devices and new analogues of Mannose-6-Phosphate (M6P). Evaluation of their angiogenic activity was made by the 'CAM essay' on embryo of chicken and in the model of the explantations of rat's aorta. First, gold nanoparticles functionnalized with M6P analogues were prepared. Those analogues have been chosen among the most interesting candidates as described previously in our laboratory. Secondly, original analogues such as a borate, a boronic acid, a pyrophosphate, a pyrophosphonate as well as the retroisotere analogue of the M6P were synthetized. The RM6P/IGFII can bind two molecules of M6P or a diphosphoryled oligosaccharide molecule by monomer (receptor). Therefore, bidentate molecules, difunctionnalized bolaform compounds and difunctionnalized trisaccharides were synthesized and their biological activity evaluated
杜鈺輝 y Yuk-fai To. "Mannose binding lectin in hepatitis B virus infection". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31225214.
Texto completoLipscombe, Richard John. "Mannose binding protein deficiency : immunochemistry and mutation analysis". Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281662.
Texto completoTo, Yuk-fai. "Mannose binding lectin in hepatitis B virus infection /". Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23435987.
Texto completoVidal, Sébastien. "Synthèse et évaluation biologique d'analogues du mannose 6-phosphate". Montpellier 2, 2000. http://www.theses.fr/2000MON20039.
Texto completoLegler, Patricia Marie. "Kinetic, magnetic, resonance, and mutational studies of the mechanisms of GDP-mannose mannosyl hydrolase, an unusual nudix enzyme". Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3046492.
Texto completoSippelli, Simona. "Nouvelle Voie d'isolement du RM6P : Biosynthèse et synthèse de dérivés du M6P". Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS157.
Texto completoThe cation-indipendent mannose-6-phosphate receptor (CI-MPR) is a trans membrane glycoprotein implicated in numerous biological processes such as the transporting of the lysosomal enzymes to the lysosomes and in the phenomenon known as angiogenesis.The analogues of M6P have proven themselves to be effectors of tumour angiogenesis.The synthesis new bidentates derivatives, functionalised with analogues derivatives of M6P, opens the way to a new method to isolate the CI-MPR.These “biological antennae” will be used to study binding affinity with the receptor CI-MPR. In prospective, a new class of Sepharose derivatives, functionalised with ours bidentates ligands, will be generated to be used in the traditional technique of purifying proteins
Chen, Ce-Belle. "The role of mannose-binding protein-associated serine proteases in complement activation : interactions with mannose-binding protein and mode of substrate recognition". Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400560.
Texto completoRutschow, Synke. "Synthese und Untersuchung membrangängiger Derivate von Mannose-1-Phosphat". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96521334X.
Texto completoSu, Yunpeng Roc. "The glycosylation of mannose receptor determines its functional specialization". Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400449.
Texto completoAbbas, Zaigham. "Development of tools to target antigen through mannose receptor". Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/14132/.
Texto completo葉偉基 y Wai-kee Eddie Ip. "Mannose-binding lectin and systemic lupus erythematosus: molecular studies". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31220952.
Texto completoPalmer, S. "The mannose-resistant adhesion antigens of uropathogenic Escherichia coli". Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380217.
Texto completoXie, Yixuan. "Synthesis And Characterization of Mannose-grafted Peptide-Like Polyesters". University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460383230.
Texto completoIp, Wai-kee Eddie. "Mannose-binding lectin and systemic lupus erythematosus : molecular studies /". Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20577138.
Texto completoStephens, Susan Ann. "Phenotypic and functional characterisation of dendritic cells in bovine afferent lymph (afferent lymph veiled cells)". Thesis, Royal Veterinary College (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251757.
Texto completoClavel, Caroline. "Synthèse et évaluation biologique de dérivés du mannose modifiés en position 6". Montpellier 2, 2004. http://www.theses.fr/2004MON20156.
Texto completoGac, Stéphanie. "Prodrogues macromoléculaires complètes associant la Norfloxacine, le Poly(L-Lysine Citramide) et un résidu mannosyle en vue de l'orientation vers les récepteurs à mannose". Montpellier 1, 1998. http://www.theses.fr/1998MON13505.
Texto completoMcKenzie, Emma Jane. "Improved immune recognition through antigen targeting to the mannose receptor". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424734.
Texto completoLing, Man-to y 凌文韜. "The role of mannose binding lectin in influenza virus infection". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085295.
Texto completoDzwonek, A. B. "The role of mannose binding lectin (MBL) in paediatric infection". Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444154/.
Texto completoLing, Man-to. "The role of mannose binding lectin in influenza virus infection". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085295.
Texto completoJohnson, M. A. "The role of mannose-binding lectin in health and disease". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446069/.
Texto completoCheng, So-kwan Florence. "Genetic susceptibility genes in tuberculosis : mannose binding lectin and interferon gamma /". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25205250.
Texto completoCendret, Virginie. "Mimes de haut-mannose et glycoclusters pour l’étude des interactions sucres-lectines". Amiens, 2010. http://www.theses.fr/2010AMIE0116.
Texto completoCells surface oligosaccharides are at the heart of many recognition processes: they are anchors to which other cells or pathogenic agents can specifically bind. In the N-glycan family, high-mannose type oligosaccharides are for instance the first species involved whenever a virus or a parasite infects a host cell. For research studies, high-mannoses therefore constitute interesting targets. However, the synthesis of these oligosaccharides remains difficult and tedious. In this context, we undertook two projects in parallel. The first one was firstly aimed at the development of a methodology providing faster access to high-mannose analogues. In order to simplify the synthesis, we chose to replace mannosidic units by triazole groups. Thus, we combined the classical glycosylation with a click chemistry reaction and after exploring several routes, we achieved the synthesis of a pseudo-octamannoside. The second stage of this project, that is to say the evaluation of this compound as N-glycans mime, is about to start. The second project stemmed from collaboration between the Laboratoire des Glucides and Dr. Sébastien Vidal team and was devoted to the synthesis of multivalent glycoclusters. In this work, a trimannoside was coupled to multivalent scaffolds such as porphyrins and calixarenes by a click chemistry reaction. Four new glycoclusters were obtained. However, their final deprotection at the end proved non trivial. To solve this problem, the coupling was realized with the free oligosaccharide. The first results are encouraging and suggest that this approach is the most appropriate for the synthesis of the desired glycoclusters. At the end of the biological assays of these compounds, we will be able to conclude about the importance of the ligand density in the carbohydrates-lectins recognition process
Robert, Stéphane. "Contribution à l'étude de la mannose 6-phosphate réductase (E. C. 1. 1. 1. 224), enzyme clé du métabolisme carbonné des plantes supérieures parasites : Purification, caractérisation et recherche d'inhibiteurs". Nantes, 1997. http://www.theses.fr/1997NANT2063.
Texto completoSome hemiparasitic ( Striga, Alectra) and holoparasitic ( Orobanche) flowering plants induce important damage in crops in the mediterranean and intertropical african areas. One of the characteristics of the metabolism of these parasites is that mannitol is the essential compound in carbon metabolism, while this central role is assumed by sucrose in most of Angiosperms. The mannitol biosynthetic pathway, which only occurs in the parasites, may be regarded as a possible metabolic target for selective chemical control. Using celery, one of the few autotrophic mannitol-producing Angiosperms, a method for purification of mannose 6-phosphate reductase (M6PR, E. C. 1. 1. 1. 224), the key enzyme of mannitol production, has been established. This method has then been used to purify the enzyme from different parasites. Steric, physical and kinetic properties of the enzyme purified from different parasites have been determined. Specific features of the M6PR from Orobanche ramosa have been demonstrated, specially the high affinity for its substrate (KmM6P ≈ 1,4 mM) and also a very high value of the optimal temperature (45°C). Inhibitory activity of several molecules structurally related to substrate or product of the enzyme, including phosphonate analogues produced by organic synthesis has also been assessed. The data allow a better understanding of the interactions involved in the recognition of the substrate by the enzyme
Houaidji, Sabrina. "SYNTHESE ET EVALUATION DE DERIVES OSIDIQUES A POTENTIEL ANGIOGENIQUE". Thesis, Montpellier, Ecole nationale supérieure de chimie, 2014. http://www.theses.fr/2014ENCM0021/document.
Texto completoOne of the challenges of the current research is to develop pharmacological tools able to curb tumor growth by specifically targeting the angiogenesis. Angiogenesis is a complex physiological process that involves a large number of receptors, among which the mannose 6-phosphate/insulin-like growth factor II (M6-P/IGF-II) receptor. Previous work conducted in the laboratory has shown that analogues of M6P are effectors of angiogenesis but during administration, these compounds are easily removed due to their hydrophilicity. To increase the lipophilicity of the M6P analogues, we replaced the methyl in position anomeric by other longer chains.We present in this manuscript, the synthesis of mannose 6-phosphate analogues and the evaluation of their angiogenesis activity by the “CAM assay”
Awwad, Azzam. "Synthèse d'analogues du mannose-6-Phosphate : activité anti-angiogénique anti-cancéreuse". Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20011.
Texto completoIn 1971, the American Dr. Judah FOLKMAN published the hypothesis : tumor growth depends on angiogenesis. The challenge of current research is to find a way to starve tumors by arresting the angiogenesis. Angiogenesis is a complex physiological process that involves many receptors, among which is the receptor for mannose-6-phosphate / insulin-like growth factor II (RM6P/IGFII). We present during this thesis, the synthesis of analogues of mannose-6-phosphate (M6P) using two different methods, and assessment of their angiogenic activity by the method of "CAM" and their anticancer activity in a model of induced tumor in mice. In order to locate the receptor, fluorescent derivatives of M6P were also synthesized and tested using the model of "CAM". On the other hand, it was shown that the RM6P/IGFII can bind two molecules of M6P or diphosphoryled oligosaccharide molecule per monomer, so bidentate molecules have been synthesized using "Green Chemistry" for evaluation of angiogenic activity
鄭素君 y So-kwan Florence Cheng. "Genetic susceptibility genes in tuberculosis: mannose binding lectin and interferon gamma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31225779.
Texto completoFidler, Katherine. "The role of mannose binding lectin (MBL) in infection and inflammation". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445448/.
Texto completoArar, Plessis Chantal. "Mr60, lectine specifique du mannose : caracterisation, clonage et regulation de l'expression". Orléans, 1995. http://www.theses.fr/1995ORLE2003.
Texto completoWright, Lisa Michelle. "Biochemical and x-ray crystallographic studies of monocot lectins in their native and ligated states". Thesis, Liverpool John Moores University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263954.
Texto completoJohnson, Claire. "Sensory and chemical analysis of the bitter-sweet taste interaction". Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262530.
Texto completoRouhier, Philippe. "Etude biochimique et activité biologique de polysaccharides et glycoconjugués fongiques". Lyon 1, 1993. http://www.theses.fr/1993LYO10016.
Texto completoZimmer, Heiko. "Untersuchungen von Mikroglia-Zellen und des Mannose-Rezeptors unter einem immunologischen Blickwinkel". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964707810.
Texto completoStorch, Stephan. "Wechselwirkungen von Proteinen mit den zytoplasmatischen Domänen der Mannose-6-Phosphat-Rezeptoren". [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=96367546X.
Texto completoTabona, Peter. "The role and regulation of mannose binding protein : studies in transgenic mice". Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297298.
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