Tesis sobre el tema "Maladie thrombo-Embolique"
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Couturaud, Francis. "Risque de maladie thrombo-embolique veineuse chez les membres de familles au premier degré de patients ayant une maladie thrombo-embolique veineuse idiopathique". Lyon 1, 2006. http://www.theses.fr/2006LYO10184.
Texto completoRational : In patients with idiopathic venous thromboembolism (VTE), the risk of recurrent VTE is high and a large proportion of these patients carry inherited thrombophilia. Our hypothesis is that patients with idiopathic VTE without detectable inherited thrombophilia have a genetic prothrombotic state not yet discovered. Objective : To evaluate the risk of VTE in first degree relatives of patients with idiopathic VTE and with or without inherited thrombophilia. If our hypothesis is true, this risk should be similar, with or without thrombophilia. Methods : In this international multicentre study, 1778 first degree relatives of 348 propositus with objectively diagnosed idiopathic VTE were included. Relatives were classified as having “certain VTE”, “uncertain VTE” or “no VTE” according to a predefined and standardised questionnaire. All the propositus were tested for the Leiden mutation and the G20210A prothrombin gene mutation. Results : In multivariate analysis, when “uncertain VTE” were classified as “No VTE”, we observed a trend of an increased risk of VTE in first degree relatives of probants with an inherited thrombophilia (relative risk of 1,52 [0,98 – 2,37], p = 0,06); when “uncertain VTE” were classified as “certain VTE”, the relative risk of VTE was closed to 1. 0 (1,18 [0,87-1,60], p = 0,3). For each level of VTE diagnosis criteria precision, there was an increased risk of VTE in first degree relatives women and in relatives from younger probants. Conclusion : The presence of an inherited thrombophilia in patients with idiopathic VTE is weakly associated with an increased risk in their first degree relatives. This observation supports our scientific hypothesis. One the main implications of this study is that the prevention of VTE should not be proposed in only first degree relatives of patients with VTE and inherited thrombophilia
Yvorra, Serge. "La maladie veineuse thrombo-embolique ambulatoire : donnees epidemiologiques, etiologiques, et suivi". Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX20856.
Texto completoPérol, Maurice. "Maladie thrombo-embolique pulmonaire chronique, éléments du pronostic : à propos de 27 observations". Lyon 1, 1989. http://www.theses.fr/1989LYO1M360.
Texto completoRiemens, Paul. "La maladie thrombo-embolique et son coût : considérations générales et en long séjour". Bordeaux 2, 1990. http://www.theses.fr/1990BOR25281.
Texto completoChalayer, Emilie. "Myélome multiple et maladie thrombo-embolique veineuse : aspects épidémiologiques, économiques, physiopathologiques et pharmacologiques". Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET007T/document.
Texto completoThe association between multiple myeloma and venous thromboembolic disease is well established. This incidence in myeloma is on average from 10 to 20%. It appears to be higher in newly diagnosed myeloma and immunomodulatory drugs such as thalidomide might significantly increase the risk. However, the risk of thrombosis due to these treatments is not yet well defined. First, we performed a review of these diseases in order to delimit the field of this study through a literature review. Then, we evaluated the incidence of venous thromboembolic disease in patients with myeloma and treated with immunomodulatory, identified the thrombotic risk factors and evaluated the thrombotic risk assessment based on the physicians choice, through an observational, multicenter, prospective French study. Moreover, we performed the medico-economic analysis of the only randomized trial conducted to date on the thrombophylaxis in patients with multiple myeloma treated with thalidomide in the first line of chemotherapy. This analysis showed a gain in quality of life associated with significant cost savings in the prevention of thrombosis by aspirin rather than heparin. Finally we performed two medical studies using thrombin generation test, a global assay that measures the overall tendency of a plasma sample to form thrombin. The first study was conducted to predict patients who will have thrombosis. The second is performed to know if a heparin resistance with the usual doses in this pathology, exists
Lanoy, Léonard Fisch Alain. "Maladie veineuse thrombo-embolique et voyage aérien de courte durée réalités et perspectives /". Créteil : Université de Paris-Val-de-Marne, 2009. http://doxa.scd.univ-paris12.fr:80/theses/th0512111.pdf.
Texto completoSCHAMBRI, YVES. "Maladie thrombo-embolique : quel bilan etiologique ? l'experience du chg de pamiers : 40 cas". Toulouse 3, 1989. http://www.theses.fr/1989TOU31107.
Texto completoBREHM, GAILHARD SYLVIE y FRANCOIS GALLEGO. "Le risque thrombo-embolique chez le sujet age hospitalise : consequences sur l'utilisation des anticoagulants". Toulouse 3, 1988. http://www.theses.fr/1988TOU31194.
Texto completoDESCHLER, SERGE. "L'heparinotherapie dans la prevention de la maladie thrombo-embolique en traumatologie et en orthopedie". Strasbourg 1, 1987. http://www.theses.fr/1987STR10680.
Texto completoLAPEYRE, FRANCOIS. "Filtres caves percutanes et maladie thrombo-embolique : indications et resultats ; revue de 180 observations". Toulouse 3, 1989. http://www.theses.fr/1989TOU31096.
Texto completoDELAHAYE, DOMINIQUE. "Maladie thrombo-embolique et deficit en proteines de la coagulation : a propos de 87 observations". Lille 2, 1988. http://www.theses.fr/1988LIL2M306.
Texto completoBosson, Jean-Luc. "La delta équivalence thérapeutique : le cas des grands échantillons : exemple de la maladie thrombo-embolique veineuse". Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE19004.
Texto completoEL, ALAMI PAYELLE NATHALIE. "Dosage des d. Dimeres en urgence : interet dans le diagnostic de la maladie veineuse thrombo-embolique". Rennes 1, 1992. http://www.theses.fr/1992REN1M033.
Texto completoNoyer, Hélène. "Maladie thrombo-embolique et puerpéralité : à propos de 87 observations sur une série continue sur 5 ans". Bordeaux 2, 1988. http://www.theses.fr/1988BOR25068.
Texto completoCapelle, Pascal. "De la rentabilité des examens complémentaires à visée étiologique dans la maladie veineuse thrombo-embolique : étude bibliographique". Montpellier 1, 2000. http://www.theses.fr/2000MON11072.
Texto completoAMROUNI, NASRADINE. "Interet de l'interruption cave temporaire (filtre thery) dans la maladie thrombo-embolique : a propos de 65 observations". Lille 2, 1988. http://www.theses.fr/1988LIL2M340.
Texto completoORTS, PHILIPPE. "Traitement thrombolytique de la maladie thrombo-embolique : a propos de dix-huit malades traites a l'hopital d'aix-en-provence de 1984 a 1986". Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20236.
Texto completoDELERUE, YVES y PATRICK CHABOT. "Suivi clinique et echographique a long terme de la maladie thrombo-embolique : a propos de 111 cas ; evaluation retrospective des therapeutiques". Lille 2, 1993. http://www.theses.fr/1993LIL2M133.
Texto completoSAMAILLE, STEPHANE y Christophe Alauze. "La maladie thrombo-embolique : une nouvelle methode d'interruption partielle de la veine cave inferieure, le filtre temporaire pieronne". Lille 2, 1988. http://www.theses.fr/1988LIL2M039.
Texto completoGHOUILA, THIERRY. "Maladie thrombo-embolique associée à un déficit en protéines C et S de la coagulation : à propos de 8 observations". Lyon 1, 1991. http://www.theses.fr/1991LYO1M225.
Texto completoTACK, TRIFAULT PASCALE. "La prise en charge de la maladie thrombo-embolique : a propos d'une etude prospective ultrasonographique, plethysmographique et scintigraphique de 104 patients". Nantes, 1988. http://www.theses.fr/1988NANT045M.
Texto completoCREMONA, MASERATI MARIE-NOEL. "Apport du dosage des d-dimeres dans la prevention de la maladie thrombo-embolique en chirurgie orthopedique : experience realisee sur six mois". Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20188.
Texto completoGaboreau, Yoann. "Méthodologies d'aide à la décision chez le patient traité par anticoagulant oral dans une maladie thrombo-embolique à partir d'études observationnelles". Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALS002.
Texto completoThe long-term aim of this thesis is to provide physicians with a strategy for estimating the risk of haemorrhage in 2 types of population: those with atrial fibrillation and those with venous thromboembolism. This strategy is based on statistical evaluation models derived from cohort studies. The first part of this thesis was devoted to a review of the literature on the pathophysiological mechanisms surrounding thrombosis, embolism and atherosclerosis. The modes of action and evidence of clinical efficacy of oral anticoagulants were researched, analysed and compared. The results of the SCORE study conclude this first part. The second part focused on validating the use of haemorrhagic risk scores in a cohort of primary care patients, and then exploring other previously unidentified risk factors (CACAO study). The third part aimed to determine the role of Covid-19 in the occurrence of thromboembolic events, based on an ancillary study of a randomized controlled trial in primary care
GILBERTON, CAILLY JOELLE. "Contribution a l'etiologie de la maladie thrombo-embolique du sujet jeune : a propos d'un cas associant un deficit hereditaire en proteine s et la presence d'une hemoglobine hyperaffine". Lyon 1, 1991. http://www.theses.fr/1991LYO1M086.
Texto completoLabarère, José. "Développement ascendant de recommandations pour la pratique clinique en situation d'incertitude scientifque : apport des arbres d'induction et application à la prévention de la maladie thrombo-embolique veineuse". Université Joseph Fourier (Grenoble), 2003. http://www.theses.fr/2003GRE19012.
Texto completoClinical practice guidelines are systematically developed statements to assist practitioner decisions about appropriate health care for specific clinical circumstances. When robust scientific evidence is lacking, clinical guidelines are derived from expert opinion. This leads to inconsistent guidelines which vary in their advice. This thesis reports the implementation of an ascending method of guideline development based on observational data in the case of prevention for venous thromboembolism. This method reduces the scientific uncertainty by extracting clinical decision rules from physician practice data. For this purpose, we used classification and regression tree methods. The accuracy of the clinical decision rules was illustrated by the rate of an outcome measure in the corresponding subsets of patients. This method reduces expert subjectivity in the process of development and increases the expected validity of the guidelines. Finally, we have demonstrated the impact of these guidelines on both physician practices and deep vein thrombosis, through a before-and-after study design
Proumen, Gérard. "Evaluation d'une héparine de bas poids moléculaire : l'enoxaparine dans la prévention de la maladie thrombo-embolique lors de la chirurgie de la hanche : étude rétrospective à partir de 237 observations". Montpellier 1, 1990. http://www.theses.fr/1990MON11056.
Texto completoAntoni, Guillemette. "Identification de facteurs génétiques modulant deux phénotypes intermédiaires de la maladie thrombo-embolique veineuse : les taux de facteurs VIII et von Willebrand : Intérêt de l’utilisation de différentes approches de recherche pangénomique". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T019/document.
Texto completoThe Venous Thromboembolism (VTE) risk factors are environmental and genetic. The well established risk factors are anti-thrombin, protein C, protein S deficiency, Factor V Leiden and factor II mutation and ABO gene, with A1 and B allele increasing the risk of VTE. While an important part of VTE heritability remains unexplained, contemporary studies fail to discover new susceptibility genes with weaker effects. In order to increase the discovery power, I searched for genetic geterminism of two intermediary phenotypes of VTE : Factor VIII plasmatic activity (FVIII) and von Willebrand factor antigenemia (vWF)First, I performed a linkage study of FVIII and vWF from a sample of 5 large pedigrees (N=255). Four loci have been identified. One included ABO gene. I searched for candidate genes located in the others loci by studying in silico results from o Genome Wide Association Study (GWAS) of the VTE including 419 cases and and 1228 controls. témoins. Two candidate genes were identified : STAB2 et BAI3. Then I performed association studies of five SNPs in BAI3 with FVIII and vWF. One of them was associated to vWF (in a sample of 108 nuclear families and 916 VTE patients), and associated to VTE in two case-controls samples (respectively 916 cases and 801 controls, and 250 cases et 607 controls).Second, I performed a meta-analysis of three GWAS of FVIII and vWF from the same 5 pedigrees and two samples of VTE (N=972 and 570) adjusted on ABO blood group. No polymorphisms were significant after Bonferoni correction (p<10-7). Nevertheless, among 11 genes carrying polymorphisms with a p<10-5, interestingly was STAB2. Futhermore, this study allowed to confirm newly discoverd association with VWF, STXBP5 et STX2
Tromeur, Cécile. "Etude des facteurs de risque cliniques de maladie veineuse thromboembolique chez les femmes : implication sur la réduction des risques liées à la stratégie diagnostique de l'embolie pulmonaire chez les femmes enceintes". Thesis, Brest, 2018. http://www.theses.fr/2018BRES0021/document.
Texto completoIntroduction : The diagnostic strategy for PE during pregnancy is uncertain due to the lack of high quality studies and the risk of radiation exposure with computed tomography pulmonary angiography (CTPA) and ventilationperfusion (V-Q) lung scan. The challenge is to validate diagnostic strategies, and to identify predictive factors to reduce the number of additional imaging tests with radiation exposure.First, we aim to identify pitfalls during the diagnostic strategy of PE (the D-dimer assay threshold, clinical probability scores, imaging) during pregnancy. Second, our objective was to compare the diagnostic efficiency of CTPA and (V-Q) lung scan during pregnancy.Third, our objective was to validate a diagnostic strategy wich reduces the number of imaging tests (adjustment of the D-dimer level on the clinical probability). Finally, the last objective was to set up a research program focused on the weight of the family history of MVTE, that may also reduce the need of additional tests. Conclusion : We identified an ongoing validation protocol with a new diagnostic algorithm in pregnant patients withPE suspicion ; Furthermore, identifying a D-dimer level adjustement as well as a family history of VTE can lead tomore effective diagnostic stragegies with less radiation exposure for pregnant women with suspected PE
Antoni, Guillemette. "Identification de facteurs génétiques modulant deux phénotypes intermédiaires de la maladie thrombo-embolique veineuse : les taux de facteurs VIII et von Willebrand : Intérêt de l'utilisation de différentes approches de recherche pangénomique". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00712143.
Texto completoGaertner, Sébastien. "Impact des facteurs de risque cardio-vasculaire majeurs d'athérosclérose et du vieillissement sur la fonction endothéliale des vaisseaux fémoraux dans le risque de thrombose veineuse". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ119/document.
Texto completoIdentification of risk factors for venous thromboembolism (VTE) is a major concern for the prevention of the disease and its recurrence. We have shown in humans that the cumulative cardiovascular risk factors (CVFR) for atherosclerosis were associated with unprovoked VTE, its severity and the risk of recurrence. Aging, CVRF and VTE risk factor, induced an endothelial dysfunction in the rat femoral vein involving cyclooxygenases (COX) associated with potential pro-thrombogenic prostanoids generation. In the young obese ZSF1 rat, cumulative CVRF induced early venous endothelial dysfunction related to COX-1 and 2. Omega-3 treatment in aging rats modulates arachidonic acid pathway leading to COX-2-mediated formation of less deleterious prostanoids, associated with a decreased thrombogenic risk, making omega-3 a potential adjuvant treatment for VTE