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Tesis sobre el tema "Liver sinusoidal endothelial cell"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 21 de febrero de 2023

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1

Cheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/2802.

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Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morpho

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Cheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells." University of Sydney, 2008. http://hdl.handle.net/2123/2802.

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Doctor of Philosophy(PhD)<br>Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has

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3

Akingbasote, J. A. "The potential role of liver sinusoidal endothelial cells in drug-induced liver injury." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3005113/.

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Liver sinusoidal endothelial cells (LSEC) constitute a unique population of endothelial cells with specialised liver-specific morphologic features and functions. LSEC are the only endothelial cells with fenestrations and which lack an organised basement membrane. They are involved in hepatic stellate cell (HSC) quiescence, endocytosis of small particles, selective transfer of substances from the blood, in the hepatic sinusoid, to the parenchymal cells and in liver regeneration. As the group of cells that form the inner lining of the capillaries of the liver sinusoids, and being the first to be

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4

O'REILLY, Jennifer. "The role and ultrastructure of the liver sinusoidal endothelial cell in fasting, hepatoxicity, and ageing." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10550.

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The majority of liver studies focus on the hepatocyte however the work of this thesis investigates the vital role of the liver sinusoidal endothelial cell (LSEC). LSECs line the liver sinusoids forming a protective barrier between the blood and hepatocytes. The LSEC cytoplasm resembles a sieve, perforated with thousands of transcellular pores of approximately 50-150 nm in diameter called fenestrations, and is underlined by a very sparse extracellular matrix. This facilitates the virtually unimpeded passage of fluid and substances smaller than fenestrations from the blood such as drugs and nutr

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5

Rowe, Ian Alston Cooper. "The role of liver sinusoidal endothelial cells in hepatitis C virus infection." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4123/.

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Hepatitis C virus (HCV) infection is a major cause of global morbidity, causing chronic liver injury that can progress to cirrhosis and hepatocellular carcinoma. The liver is a large and complex organ containing multiple cell types, including hepatocytes, sinusoidal endothelial cells (LSEC), stellate cells, Kupffer cells and biliary epithelial cells. Hepatocytes are the major reservoir supporting HCV replication, however, the role of non-‐parenchymal cells in the viral lifecycle remain largely unexplored. Endothelial cell hepatocyte co-‐cultures were established to study the role of LSEC in

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6

Mohamad, Mashani. "The Role of the Liver Sinusoidal Endothelial Cells in the Pathophysiology of Insulin Resistance." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15716.

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Ageing is associated with increased prevalence of metabolic syndrome, as well as impaired glucose metabolism, hyperinsulinemia and insulin resistance. The mechanism underlying these associations is poorly understood and is likely to be complex and multifactorial. The liver is the key target for insulin action and while the endothelium has been shown to influence insulin activity in muscle and fat, the role of the liver sinusoidal endothelium on the action of insulin in the liver is unknown. The liver sinusoidal endothelium is unique: it is perforated with transcellular pores called fenestratio

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7

Banga, Neal Roop. "Effects of Ischaemia-Reperfusion Injury and Ischaemic Preconditioning on Human Liver Sinusoidal Endothelial Cells." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515298.

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8

Kojima, Hidenobu. "Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells." Kyoto University, 2018. http://hdl.handle.net/2433/233836.

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9

Yagi, Toshikazu. "The protective effects of prostaglandin E1 on sinusoidal endothelial cells in xenogeneic pig liver perfusion." Kyoto University, 1998. http://hdl.handle.net/2433/182254.

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10

Miyachi, Yosuke. "Causes of liver steatosis influence the severity of ischemia reperfusion injury and survival after liver transplantation in rats." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263516.

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11

Ford, Andrew Joseph. "Investigating the Interplay between Inflammation and Matrix Stiffness: Evaluation of Cell Phenotype and Cytoplasmic Stiffness In Vitro." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96711.

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The cellular microenvironment in vivo consists of both mechanical and chemical signals, which drive cell function and fate. These signals include the composition, architecture, and mechanical properties of the extracellular matrix (ECM), signaling molecules secreted by cells into their surroundings, as well as physical interactions between neighboring cells. Cells are able to interact with their surroundings through a number of different mechanisms such as remodeling of the ECM through adhesion, contraction, degradation, and deposition of proteins, as well as the secretion of pro- or anti-in

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12

Yassin, Abdallah [Verfasser], Percy A. [Akademischer Betreuer] Knolle, Percy A. [Gutachter] Knolle, and Angelika [Gutachter] Schnieke. "NKT cells crosstalk with liver sinusoidal endothelial cells is triggering induction of polyclonal T-cell and NK cell immunity / Abdallah Yassin ; Gutachter: Percy A. Knolle, Angelika Schnieke ; Betreuer: Percy A. Knolle." München : Universitätsbibliothek der TU München, 2021. http://d-nb.info/1239812590/34.

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13

Zierow, Johanna [Verfasser], and Jonathan [Akademischer Betreuer] Sleeman. "Investigation of liver sinusoidal endothelial cells - characterisation and application of new transgenic mouse models / Johanna Zierow ; Betreuer: Jonathan Sleeman." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177252686/34.

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14

Pasarín, Castellanos Marcos. "Resistència a la insulina i disfunció endotelial sinusoïdal a la malaltia hepàtica per dipòsit de greix." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83491.

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La malaltia hepàtica per dipòsit de greix (MHDG) constitueix la manifestació hepàtica de la síndrome metabòlica. La seva incidència augmenta en les societats occidentals paral·lelament a la de l'obesitat. El dipòsit de greix intrahepàtic pot conduir al desenvolupament de dany hepatocitari, inflamació, fibrosi i cirrosi, però no es coneixen els mecanismes que promouen la progressió de la malaltia. No existeix un tractament farmacològic eficaç per a aquesta malaltia. La resistència a la insulina, el fet fisiopatològic subjacent a la síndrome metabòlica, condueix al desenvolupament de disfunc

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15

Takeda, Yoshihisa. "Morphologic alteration of hepatocytes and sinusoidal endothelial cells in rat fatty liver during cold preservation and the protective effect of hepatocyte growth factor." Kyoto University, 1999. http://hdl.handle.net/2433/181710.

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16

Cao, Peter. "Age-related structural changes in the liver of old mice with SIRT1 overexpression in conjunction with NMN supplementation." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16872.

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Ageing is associated with ultrastructural changes in the liver, including a reduction in hepatocyte mitochondrial number density and porosity of the liver sinusoidal cells. Histologically-verifiable changes include lipid and collagen accumulation, and increased perisinusoidal von Willebrand factor (VWF) expression. Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, is renowned for its range of anti-ageing actions. This study evaluated whether the anti-ageing effects of SIRT1 would extend to these liver ageing characteristics. Here the effects of whole-body SIRT1 overexpression on the livers of

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17

Hammoutene, Adel. "Rôle de l’autophagie dans les cellules endothéliales du foie dans le développement de la stéatohépatite non alcoolique A defect in autophagy in liver sinusoidal endothelial cells occurs in NASH and promotes inflammation and fibrosis." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB179.

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Contexte et hypothèse : La stéatohépatite non alcoolique (NASH) est définie par une accumulation excessive de lipides dans le foie (stéatose), une atteinte hépatocytaire et une inflammation hépatique avec ou sans fibrose. La NASH peut évoluer vers la cirrhose et le carcinome hépatocellulaire. De récentes études suggèrent que des altérations microvasculaires et une dysfonction endothéliale sinusoïdale précèdent l'atteinte fibreuse et inflammatoire de la NASH. L'autophagie est un processus cellulaire par lequel du matériel cytoplasmique rejoint les lysosomes pour dégradation. L'autophagie a été

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18

Neumann, Katrin. "Modulation der gewebespezifischen Migration von CD4+ T-Zellen durch das Lebersinusendothel." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16587.

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Die Einwanderung von T-Zellen in ein Gewebe wird durch selektive Wechselwirkungen mit vaskulären Endothelzellen kontrolliert. In der vorliegenden Arbeit wurde der Frage nachgegangen, ob Interaktionen zwischen Lebersinusendothelzellen (LSEC) und CD4+ T-Zellen die gewebespezifische Migration von CD4+ T-Zellen beeinflussen und damit Relevanz für den Verlauf spezifischer Immunantworten haben. Die Präsentation von Antigenen durch zytokinaktivierte LSEC erhöhte die Adhäsion und Transmigration antigenspezifischer CD4+ T-Zellen. Die Daten deuten auf eine Rolle des Lebersinusendothels bei der entzündun

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19

Warren, Alessandra. "Hepatic sinusoidal cells in liver immunology and ageing." Thesis, The University of Sydney, 2005. https://hdl.handle.net/2123/27902.

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The liver has a key role both from a metabolic and an immunological viewpoint. It is involved in the metabolism, or degradation of different molecules absorbed by the intestine, including xenobiotics, drugs and lipids, the synthesis and turnover of plasma proteins, the production of bile and the storage of glycogen and vitamin A. Unique amongst solid organs, the sinusoidal endothelium of the liver is perforated with pores, or fenestrations, and is not separated from hepatocytes by a basal lamina. It has been proposed that the fenestrations, also termed the ’liver sieve’, function as a bio-fil

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20

Nörenberg, Astrid [Verfasser], and Michael [Akademischer Betreuer] Ott. "Generation of proliferating hepatocytes, liver sinusoidal endothelial cells and stellate cells and establishment of a genotoxicity assay based on proliferating hepatocytes / Astrid Nörenberg. Klinik für Gastroenterologie, Hepatologie und Endokrinologie AG für Experimentelle und Klinische Infektionsforschung der Medizinische Hochschule Hannover. Betreuer: Michael Ott." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2014. http://d-nb.info/1050006968/34.

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21

Johnson, Sarah J. "Sinusoidal cell responses to experimental liver injury." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320389.

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22

Moriga, Takeo. "Protection by vascular endothelial growth factor against sinusoidal endothelial cell damage and apoptosis induced by cold preservation." Kyoto University, 2000. http://hdl.handle.net/2433/151416.

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23

Knight, Tamara, and Hartmut Jaeschke. "Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice." BioMed Central, 2004. http://hdl.handle.net/10150/610125.

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INTRODUCTION:Vascular injury and accumulation of red blood cells in the space of Disse (hemorrhage) is a characteristic feature of acetaminophen hepatotoxicity. However, the mechanism of nonparenchymal cell injury is unclear. Therefore, the objective was to investigate if either Kupffer cells or intracellular events in endothelial cells are responsible for the cell damage.RESULTS:Acetaminophen treatment (300 mg/kg) caused vascular nitrotyrosine staining within 1 h. Vascular injury (hemorrhage) occurred between 2 and 4 h. This paralleled the time course of parenchymal cell injury as shown by th

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24

Masek, Lisa Christina. "The study of adhesive interactions between haemopoietic progenitor cells and bone marrow sinusoidal endothelial cells." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242854.

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25

Schrage, Arnhild. "Interaktion von T-Zellen mit sinusoidalen Endothelzellen der Leber." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2006. http://dx.doi.org/10.18452/15557.

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Auch unter physiologischen Bedingungen finden sich T-Zellen und andere Leukozyten nicht nur in den Sinusoiden, sondern auch im Parenchym der Leber. Da die Leber u. a. verschiedene Aufgaben für das Immunsystem übernimmt (z. B. Deletion aktivierter T Zellen, Induktion peripherer Toleranz), könnte die Akkumulation der T-Zellen in der Leber - neben der immunologischen Überwachung der Leber - Voraussetzung für ihre Modulation sein. In der vorliegenden Arbeit wurde der Einfluss von Leber-sinusoidalen Endothelzellen (LSEC), der Barriere zwischen Blut und Leber-Parenchym, auf CD4+ T-Zellen untersucht.

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26

Legrand, Alain. "Liposomes cibles et vecteurs retroviraux pour le transfert et l'expression du gene de la preproinsuline i de rat dans des cellules eucaryotes." Orléans, 1987. http://www.theses.fr/1987ORLE2011.

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Encapsulation d'adn dans des liposomes contenant du lactosylceramide dont le sucre terminal est reconnu specifiquement par des recepteurs presents sur la membrane plasmique des cellules visees, c. A. D. , les hepatocytes et les cellules endotheliales du foie et egalement les lymphocytes de la rate. Injection par voie intraveineuse des liposomes. Role de l'endocytose, dans leur internalisation. Modele genetique constitue du gene de la preproinsuline i de rat insere dans des vecteurs retroviraux permettant l'expression du gene dans des celules non insulogenes

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27

Sun, Yu-Wen, and 孫毓雯. "Study on the Combined Transplantation of Mesenchymal Stem Cell and Liver Sinusoidal Endothelial Cell to Promote Liver Regeneration." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/84sr3g.

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碩士<br>國立陽明大學<br>臨床醫學研究所<br>102<br>Non-parenchymal cells including liver sinusoidal endothelial cell (LSECs), kupffer cell and stellate cell, especially LSECs, have been known to respond to the microenvironment and promote liver regeneration through mediating the secretion levels of cellular secretomes such as hepatocyte growth factor (HGF), Wnt2, transforming growth factors (TGFs), tumour necrosis factor (TNF-α) and interleukin 6 (IL-6). Mesenchymal stem cells (MSCs) not only have multi-differentiation potential but also contribute to tissue regeneration both in vivo and vitro by paracrine sig

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28

Kim, Andrew. "Organ transplantation and the liver tolerance effect: history, mechanisms, and potential implications for the future of transplant care." Thesis, 2017. https://hdl.handle.net/2144/23827.

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Chronic immune insult and immunosuppressant-related toxicities have remained an enduring challenge in organ transplantation. Long-term survival of transplant patients has improved marginally in recent decades due to these challenges. To circumvent these issues, transplant investigators have researched immune tolerance mechanisms that demonstrate potential to induce immunosuppression and rejection-free survival in the clinic. One mechanism in particular, the liver tolerance effect, has already demonstrated this experimentally and clinically. Liver transplants in experimental models and human pa

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29

Chen, Shin-Wei, and 陳欣蔚. "The differentiation of liver sinusoidal endothelium cells from human induced pluripotent stem cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/49410032614909348064.

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碩士<br>國立臺灣大學<br>生化科技學系<br>101<br>Hemophilia A is the most common type of hemophilia and is also known as factor VIII (FVIII) deficiency. FVIII is an essential blood clotting factor, and its defects result in the formation of fibrin deficient clots, causing bleeding. liver is a major source of FVIII and the liver sinusoidal endothelial cells (LSEC) are endothelial cells (EC) that line the hepatic microvasculature, sinusoids, which are the major cell type of FVIII production. Previous reports showed that transplantation of LSEC improved the hemophilia phenotype of mice deficient for FVIII. Thus

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30

Bleau, Christian. "Rôle des cellules endothéliales dans l’immunité innée précoce induite lors d’infections par des coronavirus murins." Thèse, 2015. http://hdl.handle.net/1866/13913.

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Les cellules endothéliales (EC) constituent une première barrière physique à la dissémination de virus pléiotropiques circulant par voie hématogène mais leur contribution à la défense innée anti-virale est peu connue. Des dysfonctions des EC de la barrière hémato-encéphalique (BMEC) et des sinusoïdes hépatiques (LSEC) ont été rapportées dans des neuropathologies et des hépatites aiguës ou chroniques d’origine virale, suggérant que des atteintes à leur intégrité contribuent à la pathogenèse. Les sérotypes de coronavirus de l’hépatite murine (MHV), se différenciant par leur capacité à induire de

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31

Papadimitriou, Minas N. B. "Adhesion of murine RAW117 lymphoma cells to hepatic sinusoidal endothelial cells: Study of surface molecule interactions under flow and effect of cyclooxygenase and lipoxygenase inhibitors." Thesis, 2000. http://hdl.handle.net/1911/19545.

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Adhesion of malignant tumor cells under flow conditions to the endothelial monolayer lining the interior of the blood vessels is an important step in the metastatic cascade. This project examined the adhesive interactions of murine RAW117 large-cell lymphoma cells to murine hepatic sinusoidal endothelial cells (HSE). Flow cytometric analysis demonstrated constitutive-expression of VCAM-1, ICAM-1, PECAM-1 and beta1 integrin subunit on the surface of both HSE and RAW117 cells. Additionally, alpha4 and beta 7 integrin subunits and MAdCAM-1 were present on the RAW117 cell surface. The dynamic adhe

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32

Hsiao, Yu-Ling, and 蕭玉翎. "Pathological effects of antibodies against dengue virus nonstructural protein 1 in liver damage and endothelial cell activation." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/20832160480205379025.

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碩士<br>國立成功大學<br>微生物暨免疫學研究所<br>91<br>Dengue virus (DV) infection causes dengue fever or severe life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). However, the pathogenesis of DHF/DSS is still not well understood. Previous studies in our laboratory showed that the AST and ALT, but not BUN, in mouse sera increased after either active immunization with DV nonstructural protein 1 (NS1) or passive administration with anti-DV NS1 antibodies (Abs). Furthermore, anti-DV NS1 Abs could bind to mouse vessel endothelium in inferior vena. In this study, we investigate the potential p

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33

Hu, Shu-Bauh, та 胡淑寶. "Effects of Interferon-α on Vascular Endothelial Growth Factor and E-cadherin Expression in Liver Cancer Cell Lines". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/27512200453751108473.

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碩士<br>高雄醫學大學<br>藥學研究所碩士在職專班<br>92<br>Purpose: Vascular endothelial growth factor(VEGF) and E-cadherin have been examined and taken for indicators of angiogenesis and metastasis respectively. In our study, we evaluated the in vitro effects of IFN-α treatment on the tumorigenicity of liver cancer cell lines. From the changes of the expression of VEGF and E-cadherin, we expected to evaluate the prognostic markers. Materials and Methods: Two well differentiated (Hep G2, Hep 3B) and one poor differentiated (SK-Hep I) human liver cancer lines were used. Cells were incubated with Interferon-α to eva

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34

Lightstone, Noam S. "Design of a Bioreactor to Mimic Hemodynamic Shear Stresses on Endothelial Cells in Microfluidic Systems." Thesis, 2014. http://hdl.handle.net/1807/65572.

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The mechanisms behind cardiovascular disease (CVD) initiation and progression are not fully elucidated. It is hypothesized that blood flow patterns regulate endothelial cell (EC) function to affect the progression of CVDs. A system that subjects ECs to physiologically-relevant shear stress waveforms within microfluidic devices has not yet been demonstrated, despite the advantages associated with the use of these devices. In this work, a bioreactor was designed to fulfill this need. Waveforms from regions commonly affected by CVDs including were derived. Pump motion and fluid flow profiles were

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Burns, C. J., E. Fantino, A. K. Powell, Steven D. Shnyder, Patricia A. Cooper, S. Nelson, C. Christophi, et al. "The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo." 2011. http://hdl.handle.net/10454/5902.

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The orally active microtubule-disrupting agent (S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2- yl)phenyl)urea (CYT997), reported previously by us (Bioorg Med Chem Lett 19:4639-4642, 2009; Mol Cancer Ther 8:3036-3045, 2009), is potently cytotoxic to a variety of cancer cell lines in vitro and shows antitumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterize the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the com

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