Literatura académica sobre el tema "Linker-less"
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Artículos de revistas sobre el tema "Linker-less"
Plater, M. John, Abbie J. Esslemont y William T. A. Harrison. "Porous and Close Packed Supramolecular Assemblies from 2,4-Difluoronitrobenzene with Three Different Linkers and an n-Butylamine Cap". International Journal of Molecular Sciences 24, n.º 19 (28 de septiembre de 2023): 14683. http://dx.doi.org/10.3390/ijms241914683.
Texto completoThielen, Nathalie, Margot Neefjes, Renske Wiegertjes, Guus van den Akker, Elly Vitters, Henk van Beuningen, Esmeralda Blaney Davidson et al. "Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region". International Journal of Molecular Sciences 22, n.º 15 (29 de julio de 2021): 8124. http://dx.doi.org/10.3390/ijms22158124.
Texto completoThiriet, C. y J. J. Hayes. "Assembly into chromatin and subtype-specific transcriptional effects of exogenous linker histones directly introduced into a living Physarum cell". Journal of Cell Science 114, n.º 5 (1 de marzo de 2001): 965–73. http://dx.doi.org/10.1242/jcs.114.5.965.
Texto completoBLACK, Gary W., Jane E. RIXON, Jonathan H. CLARKE, Geoffrey P. HAZLEWOOD, Michael K. THEODOROU, Philip MORRIS y Harry J. GILBERT. "Evidence that linker sequences and cellulose-binding domains enhance the activity of hemicellulases against complex substrates". Biochemical Journal 319, n.º 2 (15 de octubre de 1996): 515–20. http://dx.doi.org/10.1042/bj3190515.
Texto completoMathur, Rajesh, Jie Zheng, Yangyang Yan y Fred J. Sigworth. "Role of the S3-S4 Linker in Shaker Potassium Channel Activation". Journal of General Physiology 109, n.º 2 (1 de febrero de 1997): 191–99. http://dx.doi.org/10.1085/jgp.109.2.191.
Texto completoTomar, Rachana, Pankaj Sharma, Ankit Srivastava, Saurabh Bansal, Ashish y Bishwajit Kundu. "Structural and functional insights into an archaealL-asparaginase obtained through the linker-less assembly of constituent domains". Acta Crystallographica Section D Biological Crystallography 70, n.º 12 (22 de noviembre de 2014): 3187–97. http://dx.doi.org/10.1107/s1399004714023414.
Texto completoAl-Kutubi, Hanan, Alla Dikhtiarenko, Hamid Reza Zafarani, Ernst J. R. Sudhölter, Jorge Gascon y Liza Rassaei. "Facile formation of ZIF-8 thin films on ZnO nanorods". CrystEngComm 17, n.º 29 (2015): 5360–64. http://dx.doi.org/10.1039/c5ce00590f.
Texto completoShi, Fei, Song Qin y Yin-Chu Wang. "The Coevolution of Phycobilisomes: Molecular Structure Adapting to Functional Evolution". Comparative and Functional Genomics 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/230236.
Texto completoBašić, Ivana y Irena Zovko Dinković. "Sintaktički, značenjski i uporabni status složenog veznika kao i". Jezikoslovlje 23, n.º 2 (11 de enero de 2023): 281–99. http://dx.doi.org/10.29162/jez.2022.11.
Texto completoZhang, Shaodong, Ralph-Olivier Moussodia, Sabine Vértesy, Sabine André, Michael L. Klein, Hans-Joachim Gabius y Virgil Percec. "Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface". Proceedings of the National Academy of Sciences 112, n.º 18 (20 de abril de 2015): 5585–90. http://dx.doi.org/10.1073/pnas.1506220112.
Texto completoTesis sobre el tema "Linker-less"
Turelli, Lorenzo. "Étude de nouveaux motifs d'espaceurs dans la construction de conjugués anticorps-médicaments". Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAF063.
Texto completoThe class of Antibody Drug Conjugates (ADCs) represents one of the most fast-growing treatments in oncology therapeutics, enabling the use of highly cytotoxic compounds covalently linked to a monoclonal antibody (mAb) which can selectively get attached to an antigen expressed on the surface of the cancer cell, assuring the precision of this therapy. The linker motif, connecting the mAb to the drug, is key to dictate the modality of the drug’s release as for the pharmacokinetic and pharmacodynamic of the whole conjugate. However, the development of a novel linker is a costly and time-consuming process, in which the ideal motif has to assure both the stability in blood circulation and a fast kinetic in the release of the warhead inside the cancer cell. The work here described aims at addressing the limitations present in this field in two different ways: first by introducing a novel acid sensitive cleavable linker with excellent extracellular stability and selective cleavability in the cancer cell; secondly, embracing a linker-less approach, by introducing a new format of ADC, coined Self Drugged Antibody (SDA), in which the drug is built on the mAb through a Ugi multicomponent reaction
Actas de conferencias sobre el tema "Linker-less"
Kellie, Benjamin y Shaurya Prakash. "Fabrication of Ceramic High Temperature Microsystems". En ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64476.
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