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Literatura académica sobre el tema "Ligand-DNA adducts"

Autor: Grafiati

Publicado: 10 de marzo de 2023

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Artículos de revistas sobre el tema "Ligand-DNA adducts"

Astarina, Astrid, Mun Juinn Chow y Wee Han Ang. "Transcription Inhibition by Organometallic Ruthenium - Arene Anticancer Complexes in Live Mammalian Cells". Australian Journal of Chemistry 65, n.º 9 (2012): 1271. http://dx.doi.org/10.1071/ch12059.

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Organometallic ruthenium–arene RAPTA complexes, currently being actively pursued as potential anticancer agents, interact with intracellular biological targets to form covalent adducts. Because their mode of action is still unclear, we investigated their binding with DNA and the ability of ruthenated-DNA adducts to elicit cellular responses such as transcription inhibition and repair. To investigate the influence of the spectator arene ligands on RAPTA activity, a novel RAPTA complex containing the bulky 1,3,5-triisopropylbenzene ligand was synthesized and characterized. Transcription experiments carried out in live mammalian cells using ruthenated plasmid probes revealed that increasing steric bulk of the arene ligand did not improve its ability to arrest transcription.

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Gómez-Bosquet, M., V. Moreno, M. Font-Bardía y X. Solans. "Pd(II) and Pt(II) Complexes of Schiff Thiobases Derived From 2-Carbonylpyridine". Metal-Based Drugs 5, n.º 3 (1 de enero de 1998): 161–70. http://dx.doi.org/10.1155/mbd.1998.161.

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Pd(ll) and Pt(ll) complexes of three series of Schiff thiobases derived from 2- carbonylpyridine have been synthesized and characterized. The crystal structure of the Pt(ll) derivative of methyl-3-(2-pyridylmethylene)hydrazinecarbodithioate (HFp) was resolved. The ligand coordinates the platinum ion in tridentate fashion by heterocycle and imine nitrogen and thiocarbonyl sulfur. The fourth ligand is a chloride ion. The structure of the complexes is suitable for the formation of monofunctional adducts with DNA. Studies on the interaction of the complexes with Calf thymus DNA by CD reveal modifications in the B form of lineal DNA. Interaction with plasmid DNA was also confirmed in the images obtained by atomic force microscopy.

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Babu, Surendra, Pitchika Krishna, Hussain Reddy y G. H. Philip. "Synthesis, characterization and DNA cleavage activity of nickel(II) adducts with aromatic heterocyclic bases". Journal of the Serbian Chemical Society 75, n.º 1 (2010): 61–74. http://dx.doi.org/10.2298/jsc1001061b.

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Mixed ligand complexes of nickel(II) with 2,4-dihydroxyacetophenone oxime (DAPO) and 2,4-dihydroxybenzophenone oxime (DBPO) as primary ligands, and pyridine (Py) and imidazole (Im) as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II) complexes.

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Caron, Coralie, Xuan N. T. Duong, Régis Guillot, Sophie Bombard y Anton Granzhan. "Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand–DNA Adducts". Chemistry – A European Journal 25, n.º 8 (16 de enero de 2019): 1949–62. http://dx.doi.org/10.1002/chem.201805555.

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Suzuki, Yasuhito, Hulin Tai, Kaori Saito, Tomokazu Shibata, Masashi Kinoshita, Akihiro Suzuki y Yasuhiko Yamamoto. "Structural characterization of imidazole adducts of heme-DNA complexes". Journal of Porphyrins and Phthalocyanines 18, n.º 08n09 (agosto de 2014): 741–51. http://dx.doi.org/10.1142/s1088424614500515.

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Ternary complexes composed of protoheme (heme( Fe 3+)) or 13,17-bis(2-carboxylatoethyl)-3,7-diethyl-12,18-trimethyl-2,8-ditrifluoromethylporphyrinatoiron(III) (2,8-DPF( Fe 3+)), a parallel G-quadruplex DNA formed from a single repeat sequence of the human telomere, d(TTAGGG), and imidazole (Im), in a ratio of 1:1:1, were prepared and their structures were characterized using optical, circular dichroism, and NMR spectroscopies. The study revealed that heme( Fe 3+) and 2,8-DPF( Fe 3+) stack onto the 3′-terminal G-quartet of the G-quadruplex DNA, ~0.4 nm apart, and that Im is coordinated to the Fe atom on the side of the heme opposite to the G-quartet in the complex. The stacking of the pseudo-C2 symmetric heme( Fe 3+) onto the C4 symmetric G-quartet in the complex resulted in the formation of two isomers with heme orientations differing by 180° about the pseudo-C2 axis, with respect to the DNA. The Im affinity of the 2,8-DPF( Fe 3+)-DNA complex was higher by a factor of ~2 than that of the heme( Fe 3+)-DNA one, which is possibly due to the stronger ligand-to-metal π donation in the 2,8-DPF( Fe 3+) as a result of a decrease in the electron density of the heme Fe atom caused by substitution of the two strongly electron-withdrawing trifluoromethyl groups.

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Nishino, Satoshi, Teruyuki Kobayashi, Mami Kunita, Sayo Ito y Yuzo Nishida. "Structural Variety of Copper(II)-Peroxide Adducts and Its Relevance to DNA Cleavage". Zeitschrift für Naturforschung C 54, n.º 1-2 (1 de febrero de 1999): 94–99. http://dx.doi.org/10.1515/znc-1999-1-216.

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The reactivity of copper(II) compounds with several tetradentate ligands towards some spin-trapping reagents was studied in the presence of hydrogen peroxide. The compounds used in this study are roughly divided into two groups based on the reactivity towards 2 ,2 ,6 ,6 -tetramethyl-4-piperidinol(and also 2,2,6,6-tetramethyl-4-piperidone), which are trapping agents for singlet oxygen, 1O2 (1Δg); The A-group compounds exhibited a high activity to form the corresponding nitrone radical, which was detected by ESR spectroscopy, but corresponding activity of the B-group compounds was very low. The A-group compounds defined as above exhibited high activity for cleavage of DNA(supercoiled Form I) in the presence of hydrogen peroxide, yielding DNA Form II (relaxed circular) or Form III (linear duplex) under our experimental conditions ([Cu(II)]=0.1~0.5 mᴍ). On the other hand, the B-group compounds effected complete degradation of the DNA (double-strand scission) under the same experimental conditions, formation of Form II or Form III DNA was negligible. Two different DNA cleavage patterns observed for A-and B-group compounds were elucidated by the different structural property of the copper(II)-peroxide adducts, which is controlled by the interaction through both DNA and the peripheral group of the ligand system

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Vikulova, Evgeniia S., Taisiya S. Sukhikh, Sergey A. Gulyaev, Igor Yu Ilyin y Natalia B. Morozova. "Structural Diversity of Silver Fluorinated β-Diketonates: Effect of the Terminal Substituent and Solvent". Molecules 27, n.º 3 (20 de enero de 2022): 677. http://dx.doi.org/10.3390/molecules27030677.

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In order to demonstrate the role of the fluorination and some solvents in the structural organization of the Ag(I) coordination polymers with β-diketonate ligands (R1C(O)CαHC(O)R2)− we synthesized a series of the compounds containing tfac- (R1 = CH3, R2 = CF3) and pfpac- (R1 = CH3, R2 = C2F5) anions. Solvent-free [Ag(L)]∞ (L = tfac 1, pfpac 2) compounds and the corresponding acetonitrile and toluene adducts have been characterized by elemental analysis and/or NMR, IR and single-crystal XRD. This series includes five new coordination polymers. Compound 1 is a 3D coordination framework based on Ag–Ochelate/bridge, Ag–Cα bonds, and argentophilic interactions. An increase in the fluorinated group leads to a chain coordination polymer 2 of an unusual structural organization. These chains can be represented as a “DNA-type”, where two intertwined helices based on Ag–Ochelate and Ag–Cα bonds are connected through Ag–Obridge ones. Two structural types of chain coordination polymers, [Ag(tfac)(CH3CN)] and [Ag2(L)2(solvent)], have been revealed for the adducts. The latter structural type differs significantly from the previously studied toluene and acetonitrile adducts of fluorinated Ag(I) β-diketonates of the same stoichiometry. Thermal analysis in helium showed that both 1 and 2 decompose to metallic silver with the compound of pfpac-ligand being slightly more stable.

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Caron, Coralie, Xuan N. T. Duong, Régis Guillot, Sophie Bombard y Anton Granzhan. "Cover Feature: Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand–DNA Adducts (Chem. Eur. J. 8/2019)". Chemistry – A European Journal 25, n.º 8 (17 de enero de 2019): 1837. http://dx.doi.org/10.1002/chem.201806037.

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Alsaedi, Sammar, Bandar A. Babgi, Magda H. Abdellattif, Muhammad N. Arshad, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Abdullah M. Asiri y Mostafa A. Hussien. "DNA-Binding and Cytotoxicity of Copper(I) Complexes Containing Functionalized Dipyridylphenazine Ligands". Pharmaceutics 13, n.º 5 (20 de mayo de 2021): 764. http://dx.doi.org/10.3390/pharmaceutics13050764.

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A set of copper(I) coordination compounds with general formula [CuBr(PPh3)(dppz-R)] (dppz-R = dipyrido[3,2-a:2’,3’-c]phenazine (Cu-1), 11-nitrodipyrido[3,2-a:2’,3’-c]phenazine (Cu-2), 11-cyanodipyrido[3,2-a:2’,3’-c]phenazine (Cu-3), dipyrido[3,2-a:2’,3’-c]phenazine-11-phenone (Cu-4), 11,12-dimethyldipyrido[3,2-a:2’,3’-c]phenazine (Cu-5)) have been prepared and characterized by elemental analysis, 1H-NMR and 31P-NMR spectroscopies as well as mass spectrometry. The structure of Cu-1 was confirmed by X-ray crystallography. The effect of incorporating different functional groups on the dppz ligand on the binding into CT-DNA was evaluated by absorption spectroscopy, fluorescence quenching of EtBr-DNA adducts, and viscosity measurements. The functional groups affected the binding modes and hence the strength of binding affinities, as suggested by the changes in the relative viscosity. The differences in the quenching constants (Ksv) obtained from the fluorescence quenching assay highlight the importance of the functional groups in altering the binding sites on the DNA. The molecular docking data support the DNA-binding studies, with the sites and mode of interactions against B-DNA changing with the different functional groups. Evaluation of the anticancer activities of the five copper compounds against two different cancer cell lines (M-14 and MCF-7) indicated the importance of the functional groups on the dppz ligand on the anticancer activities. Among the five copper complexes, the cyano-containing complex (Cu-3) has the best anticancer activities.

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Colgrave, Michelle L., Paula Iannitti-Tito, Geoffrey Wickham y Margaret M. Sheil. "Rapid Determination of Sequence Selectivity and Stability of Alkylated Oligonucleotide Adducts by Electrospray Tandem Mass Spectrometry". Australian Journal of Chemistry 56, n.º 5 (2003): 401. http://dx.doi.org/10.1071/ch02205.

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The binding of the antitumor antibiotics, duocarmycin C2 (pyrindamycin A), duocarmycin C1 (pyrindamycin B), hedamycin, and DC92-B to self complementary oligonucleotides (ranging from 6 to 14-mers) has been studied using electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). The duocarmycins bind via non-covalent interactions in the minor groove of DNA with subsequent alkylation of the N3 atom of adenine. Hedamycin and DC92-B are intercalating, alkylating agents that target the N7 of guanines within 5′-CGT, and to a lesser extent, 5′-CGG sequences. We show here that the site(s) of alkylation by these ligands are strongly influenced by the location of high affinity binding sites within these short oligonucleotides. These data clearly demonstrate value of using ESI-MS/MS to pre-screen ligand–oligonucleotide complexes prior to performing more detailed structural studies, since subtle selectivity differences have been detected by this technique that were not evident from conventional sequencing studies on larger segments of DNA.

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Más fuentes

Tesis sobre el tema "Ligand-DNA adducts"

Papi, Francesco. "Structural investigations on the adducts formed by natural and synthetic compounds with non-canonical DNA foldings". Doctoral thesis, 2018. http://hdl.handle.net/2158/1114320.

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Non-canonical DNA structures are involved in fundamental biological processes as replication, transcription and repair. Their dysregulation is indeed connected to the development of several human diseases, including cancer. As more and more information about their existence and function in living cells are documented, such DNA structures have emerged as promising therapeutic targets. In the last decades, the G-quadruplex folding has caught the attention of scientists because of its implication in the origin and growth of various cancer forms. The stabilization of G-quadruplex structures at human telomeres is thought to be particularly attractive as it might lead to the identification of potential drug candidates with wide-spectrum anticancer activity and reduced side effects in comparison to classical chemotherapies. The research project underlying this thesis concerns the structural investigation on the interaction of non-canonical DNA foldings, especially of the human telomeric G-quadruplex, with natural and synthetic compounds in order to select potential anticancer drugs. The characterization of ligand-DNA adducts has been carried out primarily by X-ray crystallography which provides detailed structural information. In addition, alternative techniques, as CD spectroscopy and in silico calculations, have supplied complementary data with particular reference to the formation of adducts in solution.

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Libros sobre el tema "Ligand-DNA adducts"

1947-, Hemminki K. y International Agency for Research on Cancer., eds. DNA adducts: Identification and biological significance. Lyon: International Agency for Research on Cancer, 1994.

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K, Hemminki y International Agency for Research on Cancer., eds. DNA adducts: Identification and biological significance. Lyon: IARC, 1993.

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H, Phillips D., Castegnaro M. 1944-, Bartsch H, International Agency for Research on Cancer., United States. Environmental Protection Agency. y Germany Ministry of Health, eds. Postlabelling methods for detection of DNA adducts. Lyon: International Agency for Research on Cancer, 1993.

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(Editor), K. Hemminki, A. Dipple (Editor), D. E. G. Shuker (Editor), F. F. Kadlubar (Editor), D. Segerback (Editor) y H. Bartsch (Editor), eds. DNA Adducts: Identification and Biological Significance (DISCONTINUED (IARC Scient Pub)). IARC Scientific Publications, 1994.

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Phillips, D. H. Postlabelling Methods for Detection of DNA Adducts. IARC Scientific Publications, 1993.

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