Tesis sobre el tema "LDL transport"
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Weinert, Sönke. "Der interzelluläre Transport Lipid-geladener Lysosomen aus Makrophagen in glatte Gefäßmuskelzellen führt zur phänotypischen Veränderung der Gefäßmuskelzellen in einen schaumzellartigen Phänotyp". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-150397.
Texto completoCurmi, Patrick. "Transport des lipoproteines de basse densite dans la paroi arterielle. Role fonctionnel des recepteurs ldl, effets de l'hyperpression arterielle". Paris 11, 1991. http://www.theses.fr/1991PA112127.
Texto completoDachet, Christiane. "Mode d'action d'un médicament hypolipidémiant , le Probucol : transport et catabolisme des LDL, modifications des propriétés physico-chimiques des lipoprotéines plasmatiques". Paris 12, 1987. http://www.theses.fr/1987PA120055.
Texto completoDachet, Christiane. "Mode d'action d'un médicament hypolipidémiant, le Probucol transport et catabolisme des LDL, modification des propriétés physico-chimiques des lipoprotéines plasmatiques /". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376042497.
Texto completoMorris, Evan Daniel. "The role of the low-density lipoprotein receptor in transport and metabolism of LDL through the wall of normal rabbit aorta in vivo. Estimation of model parameters from optimally designed dual-tracer experiments". Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055528562.
Texto completoJesionek, Katarzyna. "Proces transportu lipoprotein niskiej gęstości (LDL) w ścianach naczyń krwionośnych". Doctoral thesis, Katowice: Uniwersytet Śląski, 2017. http://hdl.handle.net/20.500.12128/5753.
Texto completoLuvualo, Nginamau Engrácia Simão. "Recrutamento e seleção na Macon Transportes, LDA". Master's thesis, Instituto Superior de Economia e Gestão, 2016. http://hdl.handle.net/10400.5/12534.
Texto completoO presente Trabalho Final de Mestrado reflete no desenvolvimento de um estágio curricular, com duração de três meses na área de Recursos Humanos, departamento de Recrutamento e Seleção da empresa Macon Transportes Lda. O objetivo deste trabalho passa pela apresentação detalhada das atividades relacionadas com o processo de recrutamento e seleção desenvolvidas na empresa Macon. O desafio atual é a condução do processo de contratação que, na maioria das vezes é falho por falta de critérios e instrumentos adequados e que na maioria das vezes pode gerar grandes perdas financeiras e perda de tempo. Desta feita, a primeira parte do relatório é dedicado ao enquadramento teórico, seguindo-se uma breve apresentação da instituição (MACON Transportes, Lda.), na terceira parte, foram apresentadas e detalhadas as atividades realizadas ao longo do estágio, e subsequentemente na quarta foram pormenorizadas as atividades desenvolvidas na empresa no período do estágio e por fim, foram elaboradas as discussões e conclusões e apresentadas as limitações e sugestões. O objetivo final do relatório de estágio é descrever as funções exercidas e as tarefas efetuadas, explicitando a relação entre a formação obtida ao longo do curso de mestrado e a sua aplicação no trabalho na empresa.
This present Masters Degree Final Work, reflects the development of an curricular internship, with a duration of three months in Human Resources area, department of Recruitment and selection of Macon Transport Lda company. The objective of this work goes through the detailed presentation of activities related to the procedure for recruitment and selection developed in Macon Company. . The current challenge is to leading the hiring process that most of the times it´s flawed for lack of criteria and instrument that in most of the times can cause great financial and time losses. By this, the first part of the report is dedicated to the theoretical framework, followed by a brief presentation of the institution (MACON Transportes, Lda.), in the third part, we were presented and detailed the activities carried out throughout the internship, and subsequently in the fourth they were detailed the activities developed at the company at internship period and finally were prepared the discussions and conclusions and brought the limitations and suggestions. The ultimate goal of internship report is to describe the functions exercised and performed tasks, explaining the relation between the training obtained along master course and its application at work in the company
Yang, Xiao. "Green Hub Location-Routing Problem for LTL transport". Thesis, Nantes, 2018. http://www.theses.fr/2018NANT4034/document.
Texto completoWe study the Hub Location-Routing Problem (HLRP) aiming at the design of an efficient freight transportation network for LTL (less-than-truck) transport between many origins (suppliers) and destinations (clients). Such a network relies on the location of consolidation hubs, the organization of routings for the collection/distribution of freight from suppliers to hubs and from hubs to clients, as well as direct shipment of consolidated freight between hubs. We focus on the Capacitated Single Allocation Hub Location-Routing Problem (CSAHLRP) in the case of distinct collection and delivery processes. We propose mixed integer linear programming (MILP) model and a Memetic Algorithm (MA) to solve the problem for minimizing the total cost of the network. Then we extend the model into a bi-objective model for minimizing both the total cost and CO2 emissions of transport. A modified memetic algorithm (MA) combined with a fast elitist non-dominated sorting genetic algorithm (NSGAII) is developed to capture the trade-off between minimizing total cost and CO2 emissions and exhibit approximations of the Pareto front. At last, a two step procedure is proposed to solve the single-objective HLRP based on a hub location problem (HLP) and two distinct vehicle routing problems for suppliers and clients allocated to each hub by the first step. Our single objective MILP model is decomposed accordingly and our MA is adapted to solve the HLRP following these two steps. A data base of instances of different sizes and characteristics has been developed in order to conduct extensive experiments for solving all these problems using the different solution techniques and validate our approaches
Mebrahtu, Fanuel M. "Transport and extraction of Au(lll) using thiourea ligands". Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/50206.
Texto completoENGLISH ABSTRACT: A series of di- and mono-substituted acyl(aroyl) thioureas were examined for the extraction and transportation of Au(III). Two-phase metal ion extraction experiments were employed to investigate the extraction behaviour of these ligands. The effect of varying ligand concentration on the extraction trend of these ligands was investigated. The results show that the different substituent groups on the benzoyl ring can affect the extraction pattern of the metal. Furthermore, the alkyl substituents on the thiourea moiety and varying the ligand concentration have an influence on the percentage of metal ion extracted. With the exception of the H2L2(N,N-di-propyl-N'- benzoylthiourea ) ligand the di-alkyl substituted thioureas were more efficient for the metal ion extraction than the mono-alkyl ligands. In almost all the experimental set ups there was reduction of the Au(lIl) to Au(l) and Au(O) but it was more pronounced with HL3 (N,N-di-(2-hydroxyethyl)-N'-benzoylthiourea). Transport experiments were also conducted, the experimental set up for transportation was a concentric type cell involving a 3-phase system - 2 aqueous phases ( source and receiving phase) separated by a chloroform membrane incorporating the ligand. The transport results however only gave a satisfactory result of about 5% of gold transported by the HL1 (N,N-dibutyl-N'-benzoylthiourea). All other ligands attempted resulted in metal ion being present in the organic phase, but no metal ion present in the receiving phase. To help drive the transport of the metal ion to the receiving phase CN-, S203 2- and perchloric acid were incorporated into the receiving phase. The transport results were not enhanced with these substances being present in the aqueous receiving phase. The aqueous source and receiving phases were analyzed by flame atomic absorption spectroscopy (FAAS). Finally the N,N-diethyl-N'-camphanoylthiourea (HL10) ligand and its complex with Au(l) were synthesised. Single crystals of the complex were grown for X-ray crystallography and the crystal and molecular structure of the complex was determined. The complex crystallizes in the monoclinic space group P21. The cell parameters are a = 10.7356(7)A b = 16.3443(11)A c = 10.9268(7)A f3 = 103.1450(10t , and final R-factor of 1.76%. The coordination sphere around Au(l) shows a nearly linear arrangement of sulphur and chloride.
AFRIKAANSE OPSOMMING: In hierdie proefskrif is In aantal mono- en di-gesubstitueerde asiel(ariel) thioureums ondersoek vir die transportasie en ekstraksie van Au(III). Twee-fase metaalioon vloeistof-vloeistof ekstraksie eksperimente is gebruik om die ekstraksie patroon van hierdie ligande te ondersoek. Die effek van verskillende ligand konsentrasies op die ekstraksie neiging van hierdie ligande is ondersoek. Resultate toon dat die verskillende substituente op die benziel ring die ekstraksie patroon van die metaalioon beïnvloed. Verder, is gevind dat die alkiel substituente op die thioureum saam met varierende ligand konsentrasies geensins die metaalioon ekstraksie beïnvloed nie. Met die uitsondering van H2L2 (N,N-dipropiel-N'-benzielthioureum) is die di-alkiel gesubstitueerde ligande meer effektief vir metaalioon ekstraksie in vergelyking met die mono-alkiel ligande. In baie van die eksperimente is In reduksie van Au(llI) na Au(l) en Au(O) gesien en dit is baie duidelik met ligand HL3 (N,N-di(2- hidroksie-etiel)N'-benzielthioureum). Alle waterige fases is ge-analiseer met gebruik van Atoomabsorpsie Spektroskopie (AAS). Transportasie eksperimente is ook uitgevoer met gebruik van In drie-fase selsisteem. Twee waterige fases (bron- en ontvang-fase) is geskei met die chloroform membraan fase wat die ligande bevat. Hierdie eksperimente het net In 5% Au(lll) transportasie getoon met HL1(N,N-dibutiel-N'-benzielthioureum). Daar was geen transportasie van Au(lIl) met enige van die ander ligande. Analise van die twee waterige fases het getoon dat die metaalioon eindelik goed ge-ekstraeer is en is teenwoordig in die membraan fase. Om die transportasie van Au(lIl) aan te spoor, is CN-, s2ol- en perchloorsuur in die ontvang-fase geinkorporeer. Die resultate was geensins beïnvloed nie. N,N-di-etiel-N'-kamfonielthioureum (HL10)ligande en die kompleks daarvan met Au(l) is ook gesintetiseer. Enkel-kristalle van die kompleks is verkry en X-straal kristallografiese analiese is onderneem. Hierdie kompleks kristalliseer in die monokliniese ruimtegroep P21,met a =10.7356(7)Á, b=16.3443(11)Á, c=10.9268(7)Á en ~=103.1450(10t. Die finale R-faktor is 1.76%. Die koordinasie om Au(l) toon In liniêre geometrie met swael en chloor.
Wirbeleit, Frank. "Arsenic diffusivity study by comparison of post-Surface and post-implant diffusion in silicon with Local Density Diffusion (LDD-) model approximation". Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-186124.
Texto completoTorelli, Daniele. "Functionals for TDDFT description of electron transport in nanostructures". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11143/.
Texto completoCunningham, Gavin James. "Predicting entrainment of mixed size sediment grains by probabilistic methods". Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU122469.
Texto completoWirbeleit, Frank. "Arsenic diffusivity study by comparison of post-Surface and post-implant diffusion in silicon with Local Density Diffusion (LDD-) model approximation". Diffusion fundamentals 15 (2011) 3, S. 1-10, 2011. https://ul.qucosa.de/id/qucosa%3A13836.
Texto completoPrado, André Alarcon de Almeida. "Modelagem do problema de localização/roteirização para o transporte de carga fracionada". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/3/3138/tde-24022017-080052/.
Texto completoIn the Less Than Truck Load (LTL) operations both the location of facilities and the routing of vehicles are important decisions for the optimal design of the related logistics network. Two interdependent problems arise: the Location Allocation Problem (LAP) and the Vehicle Routing Problem (VRP). This paper presents a mathematical model to solve the LAP and the VRP simultaneously on an integrated way, such as the so-called Location-Routing Problem (LRP). According to the literature the LRP integrated approach provides better results than considering the LAP and the VRP separately. The model was tested and applied to a real case of Many-to-Many with Multi-Echelons LTL Location-Routing Problem respecting the constraints and the required service level standard and provided better results for the company in which it was tested. The model results also were better than the results presented by market-leading software.
Guichard, Romain. "Dynamique d'un aérosol de nanoparticules : modélisation de la coagulation et du transport d'agrégats". Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0137/document.
Texto completoA complete CFD model for nano-aerosol dynamics is presented and discussed. It consists in an Eulerian "Diffusion-Inertia" equation including a coagulation source term which is rewritten in terms of moments. Deposition phenomenon is taken into account by means of a boundary condition on the flux of moments at walls. The moment transformation allows good computational performances and makes thus the model tractable for industrial and occupational health applications. The implementation of this approach into a CFD code is assessed for simple cases by comparison with sectional approach results and experimental data. These comparisons show that the method of moments does not induce particular bias and that numerical results are in good agreement with available experimental data. An experimental set-up, which consists in a ventilated chamber, is also proposed for allowing a good control of the flow and for allowing the investigation of aggregates morphology. The confrontation between numerical and experimental results highlights that the determination of the fractal parameters is a modelling key point
Calala, Paulina Celmira João. "O sistema de remunerações e benefícios empresariais : influência na satisfação no trabalho : caso dos Motoristas da Macon Transportes Lda". Master's thesis, Instituto Superior de Economia e Gestão, 2016. http://hdl.handle.net/10400.5/12530.
Texto completoO presente relatório tem como objetivo central identificar os tipos de recompensas (monetária ou não monetária) utilizadas pela empresa Macon Transportes, Lda, conhecer e identificar a relação existente entre as variáveis em estudo e a satisfação no trabalho dos seus motoristas. Para dar coerência ao raciocínio no decurso do seu desenvolvimento, cedemos privilégio, em primeiro lugar a abordagens acerca dos conceitos sobre o sistema de remunerações, benefício, satisfação, por conseguinte a relação entre as teorias dos conceitos e a aplicação na prática empresarial, dando ênfase à parte prática desenvolvida no decorrer da fase de estágio. Para melhor aprofundamento, percepção, identificação e conhecimento das variáveis em destaque, inquirimos uma amostra que foi costituída por 90 motoristas das várias áreas de serviço, notificados por meio de entrevista (ver guião de entrevista anexo 3 e 4). Os resultados obtidos evidenciam que os colaboradores e particularmente os motoristas da Macon, apesar das dificuldades, estão satisfeitos com o que recebem salarialmente em relação à função que desempenham, e mostram-se mais satisfeitos ainda, com os benefícios e com as condiçoes de trabalho, oferecidas pela organização. Não obstante a atual situação da crise económica do País que assola profundamente quer de forma direta ou indireta as organizações, aos trabalhadores e a população em geral.
This report is mainly aimed to identify the types of rewards (monetary or non-monetary) used by the company Macon Transportes, Lda., Know and identify the relationship between the study variables and job satisfaction of their drivers. To give coherence to the reasoning in the course of its development, we give privilege, first approaches about the concepts of the remuneration system, benefit, satisfaction, therefore the relationship between the theories of concepts and application in business practice, emphasizing the practice of developed during the training phase. For deeper understanding, perception, identification and knowledge of the highlighted variable, we inquire a sample was qu costituida by 90 drivers from various areas of service, contacted through interviews and questionnaires (interview guide in Annex 3 and 4). The results show that the employees and particularly drivers of Macon, despite the difficulties, are satisfied with the salary they receive in relation to their function, and show even more satisfied with the benefits and the conditions of work, offered by the organization. Despite the current situation of the country's economic crisis plaguing deeply either directly or indirectly organizations, workers and the general population. Not having many options for employment improvements in the short and medium term.
Sůva, Lukáš. "Námořní kontejnerová přeprava mezi Čínou a Evropou na příkladu firmy DB Schenker". Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-264558.
Texto completoSalisu, Nadezda y Lina Olsson. "Towards environmentally sustainable development in the food retail industry : A case study of Lidl Sweden". Thesis, Mälardalens högskola, Akademin för ekonomi, samhälle och teknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-25384.
Texto completoPospíchal, Jiří. "Sběrná služba v námořní přepravě a export z ČR". Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-72782.
Texto completoFigueiredo, Roberta Marcondes Machado. "Efeito dos ácidos graxos saturados, poli-insaturados e trans no desenvolvimento de aterosclerose e esteatose hepática em camundongos com ablação gênica do receptor de LDL". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-18012013-145918/.
Texto completoIntroduction: The amount and type of dietary fat play important roles on the development of cardiovascular disease (CVD) and on the development of hepatic steatosis. Saturated (SAT) and trans (TRANS) fatty acids are known as pro-atherogenic, while the polyunsaturated (POLY) fats seem to exert an antiatherogenic action. Regarding hepatic steatosis, it is known that SAT are associated with its development, however, the role of TRANS in the genesis and development of hepatic steatosis is not fully undestood. This study evaluated the effect of the intake of diets enriched with SAT, POLY or TRANS on the parameters involved in the progression of the atherosclerotic plaque and also on the development of the nonalcoholic fatty liver disease (NAFLD). Methods: LDL receptor knock-out (LDLR-KO) male mice were fed for 16 weeks a high fat diet (40% of calories as fat) enriched with SAT, POLY or TRANS, for 16 weeks. The following parameters were mesured: 1) plasma: total cholesterol (TC), triglyceride (TG), insulin, glucose, aspartate aminotransferase (AST) and alanine amino transferase (ALT), interleukin-6 (IL-6), tumor necrosis factor- ? (TNF-?) and lipoprotein profile; 2) atherosclerotic lesion - lesion area (Oil Red-O), ATP-binding cassette transporter A1 (ABCA1) content and macrophage infiltration (immunohistochemistry), co-localization of ABCA1 and macrophages (confocal microscopy) and collagen content (Picrosirius-Red); 3) TC, cholesteryl ester (CE) and free cholesterol (FC) content of the total aorta; 4) interleukin-6 and 10 (IL-6 and IL-10) and TNF-alfa in the culture medium of peritoneal macrophages after treatment with lipopolysaccharide (LPS); 5) liver: degree of fat liver disease, concentration of TC and TG and mRNA expression (RT-qPCR) of PPAR-gama, PPAR-gama, SREBP-1c, MTP, ABCA1 and CPT-1; 6) visceral and subcutaneous adipose tissue contents in the carcass of the animals. Results: Food intake did not differ amongst the groups, however, compared to POLY, TRANS induced less weight gain, due to lower adipose tissue content. TRANS induced hepatomegaly, nonalcoholic steatohepatitis (NASH) and worsening of insulin sensitivity, as evidenced by the index HOMAIR. The concentrations of ALT and AST did not differ among groups. TRANS increased the mRNA expression of the hepatic lipogenic genes (PPAR-gama and SREBP-1c) compared to the SAT and POLY and reduced the mRNA expression of MTP compared to POLI. There was no difference among the groups regarding the mRNA expression of genes involved in hepatic lipid oxidation (PPAR-gama and CPT-1). Plasma concentrations of TC and TG were higher in TRANS compared to SAT and POLY. POLY showed lower arterial lesion area, macrophage infiltration and ABCA1 content compared to SAT and TRANS. ABCA1 and macrophages did not colocalize in the lesion area. The TC content in the arterial wall was lower on POLY compared to TRANS; FC was lower on POLY compared to SAT and TRANS; CE did not differ among groups. Compared to POLY, SAT and TRANS showed higher collagen content and necrotic core in atherosclerotic plaques. The plasma concentration of IL-6 did not differ among groups, however, TNF-alfa plasma concentration was higher in POLY and TRANS compared to SAT. Regarding the macrophage inflammatory response to LPS, POLY and TRANS showed higher concentrations of IL-6 and TNF-alfa compared to SAT. Moreover, POLY had the lowest concentration of the anti-inflammatory cytokine IL-10. The hepatic expression of ABCA1 did not differ amongst the groups. Conclusion: TRANS induced pro-atherogenic lipid profile, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, and severe atherosclerosis, and in addition, elicted hepatomegaly, increased hepatic lipid accumulation and NASH. On the other hand, POLY prevented the development of atherosclerosis, independently of their pro-inflammatory activity.
LI, PETRI Giovanna. "SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES AS ANTICANCER AND ANTIBIOFILM AGENTS, AND PRECLINICAL INVESTIGATION OF ANTI-LDH-A COMPOUNDS AGAINST MALIGNANT MESOTHELIOMA". Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395253.
Texto completoAndersson, Harald. "Numerical and experimental study of confluent jets supply device with variable airflow". Licentiate thesis, Högskolan i Gävle, Energisystem och byggnadsteknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-29271.
Texto completoUnder senare tid har applikation av Confluent jets för design av tilluftsdon studerats. Många studier har även utförts över potentialen av att applicera variabelt luftflöde (VAV) för att minska energianvändningen i ventilationssystem. Denna studie undersöker möjligheten att kombinera Confluent jets-don med VAV, både med avseende på den lokala flödesbilden och dess påverkan på termisk komfort, luftkvalitet och energieffektivitet i en klassrumsmiljö där luftflödes varieras. Denna studie baseras dels på en experimentell fältstudie där tilluftsdon baserade på Confluents jets jämfördes med befintliga deplacerande tilluftsdon. Fältstudien utvärderade energieffektiviteten, den termiska komforten och luftkvaliteten för båda typerna av tillluftsdon. Confluent jets-donen testades under varierat luftflöde för att se påverkan av flödesvariationen på ventilationens prestation under de olika flödena. Utöver fältstudien testades Confluent jets-donen experimentellt och numeriskt i ett välisolerat test-rum för få den detaljerade flödeskarakteristiken för den här typen tilluftsdon vid varierat luftflöde. Resultaten från fältstudien visar på en jämn fördelning av den lokala luftsmedelåldern i vistelsezonen, även för fallen med relativt låga luftflöden. Luftflöden har ingen signifikant effekt på omblandningen. Den termiska komforten i klassrummet ökade när luftflödet anpassades efter värmelasten jämfört med de deplacerande donen. Slutsatsen från fältstudien är att kombinationen av VAV och Confluent jets-don kan användas för att minska energianvändningen på skolan och bevara luftkvaliteten och den termiska komforten i vistelsezonen. Resultaten från den experimental och numeriska studien visar luftflödet och lufthastigheten i varje enskild dysa är direkt beroende på det totala luftflödet genom donet. Dock är flödesfördelningen mellan dysorna oberoende av de tre olika luftflödena. Den numeriska undersökningen visar att flödesprofilen för varje dysa är konstant trots att flödet varieras, men amplituden för varje profil ökar med en höjning av luftflödet. Det betyder att tilluftsdon av den här typen kan användas med VAV för att producera Confluent jets för olika luftflöden. Resultaten från båda studierna visar att luftflöde inte påverkar fördelningen av luften vare sig längs luftdonen eller på rumsnivå. Fördelningen av luften är nästan helt jämn längs donen och på rumsnivå är omblandningen och luftkvalitet den samma för varje luftflöde. Det betyder att det finns potential för att kombinera det här två teknikerna för att designa luftdistribueringssystem med hög energieffektivitet och hög termisk komfort med god luftkvalitet.
Jenty, Marion. "Rôle de la signalisation LRP1/Wnt5a dans le métabolisme du cholestérol". Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ025/document.
Texto completoProtects against intracellular cholesterol accumulation and we identified the secreted protein Wnt5a as a partner of this inhibitory effect of LRP1. The aim of this thesis is to determine the molecular mechanisms by which the LRP1/Wnt5a signaling pathway prevents cholesterol accumulation in cells and to study the antiatherogenic potential of Wnt5a. We first showed in vitro and in vivo that Wnt5a decreases cellular cholesterol content by stimulating its efflux through the induction of cholesterol transporters expression and by down-regulating the expression of HMGCoA-reductase. Then we used mice deleted for Wnt5a specifically in smooth muscle cells, which present more atherosclerotic lesions than control mice after a high cholesterol diet. This confirms that Wnt5a protects against atherosclerosis and could be an interesting therapeutic target in the treatment of the disease
Chin, Trow-Wey y 秦作威. "Transendothelial Transport of Low Density Lipoprotein (LDL) in Association with Cell Death in Rat Aorta". Thesis, 1998. http://ndltd.ncl.edu.tw/handle/51704901055395896259.
Texto completoWeinert, Sönke. "Der interzelluläre Transport Lipid-geladener Lysosomen aus Makrophagen in glatte Gefäßmuskelzellen führt zur phänotypischen Veränderung der Gefäßmuskelzellen in einen schaumzellartigen Phänotyp". Doctoral thesis, 2013. https://tud.qucosa.de/id/qucosa%3A28238.
Texto completoGolatkar, Poorva. "Modeling Of Transport Phenomena In Arteries". Thesis, 2010. http://etd.iisc.ernet.in/handle/2005/2001.
Texto completoTall, Renee Danielle. "Intracellular trafficking of influenza hemagglutinin and members of the low density lipoprotein receptor family". 2004. http://edissertations.library.swmed.edu/pdf/TallR121504/TallRenee.pdf.
Texto completoSengupta, Bhaswati. "Validation of a novel hypothesis of generating foam cells by its use to study reverse cholesterol transport". Doctoral diss., 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6176.
Texto completoPh.D.
Doctorate
Molecular Biology and Microbiology
Medicine
Biomedical Sciences
Jang, Shyh-ing. "Low-density lipoprotein (LDL) as transporter for 2,2',4,4',5,5'-hexabromobiphenyl (HBB) into the cell". 1992. http://books.google.com/books?id=l2I9AAAAMAAJ.
Texto completoPiriquito, Dinis Narciso Nascimento Reis. "Caso de sucesso: empresa de transportes Heitor & Carlos, LDA". Master's thesis, 2010. http://hdl.handle.net/10071/2808.
Texto completoThe case study herein presented aims its goal to a thorough analysis at the grounded strategy operated by the company Transportes Heitor & Carlos, Lda., from its establishment up to the present day, outstanding and depicting its surroundings. Based upon revised literature namely on the transaction cost theory, the Uppsala School model, the networking theory and Michael Porter’s studies, it was possible to accomplish a detailed and grounded analysis of THC. A first approach was devoted to the study of the evolution of the national and Europeanwide freight transport sector, focusing on the crescent importance of highways in road transports operations. A characterization of the logistical sector was carried out for it represents a more narrowed market with a high-level potential, thus allowing a more value-added service offered to the client. The inside analysis of the company gave the definition of the vision, mission, values and policies adopted, aiming the potential business growth through the positive association of the strongest key points and opportunities, and questing for the minimization of negative association of possible threats and weaknesses. The internationalization process of THC is a basic result of a follow-up client strategy that conducts to a company-client relationship improvement thus excluding barriers. At the same time, the firm reinforces its posture in the Iberian Peninsula and becomes closer to the centre of Europe.
LIAO, CHEN-HONG y 廖宸宏. "Based on DFB and VCSEL LDs associated with injection locked building ROF transport system". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/y6jhff.
Texto completo明志科技大學
電機工程系碩士班
104
In recent years, there are many new technologies such as optical communication, cloud technology, smart appliances, etc. These techniques often require high bandwidth capacity in fiber-optic transmission systems. The traditional optical double sideband (ODSB) modulation could cause severe optical dispersion in radio-on-fiber (ROF) system. Optical single sideband (OSSB) modulation is usually used to solve it. OSSB modulation can suppress the power dissipation effectively and extend the signal transmission distance. In addition a new cutting edge technology, Free-Space Optical (FSO), is born to fulfill the needs of high speed transmission. FSO is able to avoid the radio jam problem. We propose two kinds of architectures in this paper. Architecture I:In the proposed scheme, the downlink signal is modulated by the optical single sideband (OSSB) signal. The downlink wavelength is reused for uplink in Base station (BS). Based on injection-locked Distributed Feedback (DFB) Lasers and stimulated Brillouin scattering (SBS) achieve OSSB modulation. The two kinds of technologies fall on frequency band approximately nearby 10.8 GHz. The frequency band is used to enhance OSSB signal. After pass through an optical interleaver (IL). The even and odd port of the IL is used to separate the downstream and upstream signal, respectively. In our proposed bidirectional transmission system, the performances of bit error rate analysis are good. Architecture II:Vertical-cavity surface-emitting laser (VCSEL) based free-space optical (FSO) communication employing three-stage injection-locked technique and the afocal scheme is proposed and experimentally demonstrated. The three-stage injection-locked technique, which can significantly increase the resonant frequency of the VCSEL, is expected to provide higher transmission rate in FSO communication. The afocal scheme, which can reduce the beam size of laser beam, is expected to provide longer free-space link in FSO communication. Such VCSEL based FSO communication provides the advantages of optical wireless links for longer transmission distance and higher transmission rate, which is thoroughly useful for high-speed light-based WiFi (LiFi) applications.
Fen, Chun-Chen y 范純禎. "Employing Mutually Injection-Locked FP LDs Scheme over Full-Duplex Radio-on-Fiber Transport Systems". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/qryejh.
Texto completo國立臺北科技大學
光電與通訊產業研發碩士專班
97
A full-duplex ROF transport system based on mutually FP LDs is proposed and demonstrated. Transmission performances over a-40 km standard SMF for full-duplex transmission were investigated. Good performance of BER was achieved in our proposed systems. We directly modulate the FP LDs in mutually injection-locked scheme instead of using expensive external modulator and sophisticated optical carrier suppression technique; it reveals an outstanding alternative with advantages in simplicity and cost.
Cocchiaro, Jordan Lindsey. "Chlamydia Subversion of Host Lipid Transport: Interactions with Cytoplasmic Lipid Droplets". Diss., 2009. http://hdl.handle.net/10161/1219.
Texto completoThe
We find that LDs are recruited to the
In these studies, we identify eukaryotic lipid droplets (LDs) as a novel target organelle important for
Dissertation
Cascão, Pedro Daniel Vieira. "Abordagem Lean a uma oficina mecânica caso prático : transportes Cascão e Manuela, Lda". Master's thesis, 2018. http://hdl.handle.net/10400.26/29606.
Texto completoEiras, Guida Eduarda Martins. "Estudo de caso: transporte e comercialização de leite no âmbito empresarial". Master's thesis, 2014. http://hdl.handle.net/10198/11581.
Texto completoMilk is a product of high nutritional quality, filling a tangible place in the human diet particularly during childhood. It is constituted mainly by water, yet having a significant content of protein and fat, and the value of these parameters varies considering the producing species. This food product has to reach its consumers in the best salubrity and safety circumstances and should be guaranteed conditions of temperature and performance procedures capable of ensuring such an outcome. The entire production process must be monitored, wherein the realization of this internship focused on the process of milk collection and transportation. At the host institution, Transportes Quintino Augusto Branco & Filhos Lda, various procedures with the ultimate aim of ensuring product quality at the time of delivery to the industry were conducted. The treatment of relevant documentation or issuance of payment orders were some of the activities undertaken. On a more practical component were carried out procedures to control quality parameters’, including temperature monitoring at key moments and the study of chemical analyzes performed after collecting the milk. For the latter was conducted a statistical analysis of the results produced over nine months to parameters such as fat, protein, dry matter, somatic cells, microbial count and cryoscopic index. The results indicate the influence of the month of collection in the values obtained for the evaluated criteria, where most of these suffered a decrease in the cold months. The microbial and somatic cell count are values considered by the Company. The first presents itself positive, does not occur any penalizations unlike the second case where penalization is the average classification should be taken into account performing procedures for locating possible procedural flaws. This period proved to be a stage of intense learning enabling a greater understanding of the functioning of the milk transporting sector and the importance and advantages of the control of quality parameters throughout the entire production process.
Jena, Hrudananda. "Ionic Transport And Structural Investigations On Selected Perovskites Synthesized By Wet Chemical Methods". Thesis, 2004. http://etd.iisc.ernet.in/handle/2005/1260.
Texto completoRenaud, Julien. "Caractérisation des fonctions de transport du cholestérol des sous-types de macrophages M1 et M2 issus de cellules THP-1". Thèse, 2018. http://hdl.handle.net/1866/21374.
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