Bibliografías temáticas / LC-MS methods / Tesis
Siga este enlace para ver otros tipos de publicaciones sobre el tema: LC-MS methods.

Tesis sobre el tema "LC-MS methods"

Autor: Grafiati
Publicado: 10 de marzo de 2023
Última modificación: 31 de julio de 2025

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros

Elija tipo de fuente:

Consulte los 50 mejores tesis para su investigación sobre el tema "LC-MS methods".

Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.

También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.

Explore tesis sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.

1

Zhao, Ruoxia. "Investigation of Ribonucleic Acid Post-transcriptional Modifications by Optimized LC-MS/MS Methods." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623240214971428.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Sharp, Julia Lynn. "New Statistical Methods for Analyzing Proteomics Data from Affinity Isolation LC-MS/MS Experiments." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/sharp/SharpJ0807.pdf.

Texto completo
Resumen
The field of proteomics is exploding with statistical problems waiting to be explored. To obtain information on protein complexes, interactions between protein pairs is initially examined. This exploration is performed using `bait-prey' protein pull-down assays that use a protein affinity agent and an LC-MS/MS (liquid chromatography-tandem mass-spectrometry)-based protein identifcation method. An experiment generates a protein association matrix wherein each column represents a sample from one bait protein, each row represents one prey protein and each cell contains a presence/absence associat
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Li, Lan. "Development of Quantitative LC-MS/MS Methods for the Pharmacological Studies of Anti-Cancer Drugs." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1299117212.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Nezami, Ranjbar Mohammad Rasoul. "Novel Preprocessing and Normalization Methods for Analysis of GC/LC-MS Data." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73499.

Texto completo
Resumen
We introduce new methods for preprocessing and normalization of data acquired by gas/liquid chromatography coupled with mass spectrometry (GC/LC-MS). Normalization is desired prior to subsequent statistical analysis to adjust variabilities in ion intensities that are not caused by biological differences. There are different sources of experimental bias including variabilities in sample collection, sample storage, poor experimental design, noise, etc. Also, instrument variability in experiments involving a large number of runs leads to a significant drift in intensity measurements. We propose n
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Cai, Xiaohan. "¿¿¿¿¿¿Development of Bioanalytical Methods for Clinical Applications and Drug Screening." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1314982525.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Minten, Johanna. "Development of methods for the analysis of polar compounds in environmental matrices using LC/UV and LC/MS /." Stockholm : Department of applied environmental science (ITM), Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29108.

Texto completo
Resumen
Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Submitted. Härtill 4 uppsatser.
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Abbas, Ioana. "Development of LC-MS/MS methods for the quantitative determination of hepcidin-25, a key regulator of iron metabolism." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19358.

Texto completo
Resumen
Hepcidin-25, ein 2000 entdecktes Peptidhormon, das eine Schlüsselrolle im Eisenstoffwechsel spielt, hat das Verständnis von Eisenerkrankungen revolutioniert. In dieser Studie wurde LC gekoppelt mit einem Triple-Quadrupol MS in einer schnellen und robusten Methode zur Quantifizierung von Hepcidin-25 in menschlichem Serum verwendet, welche letztlich in Routine-Laboratorien genutzt werden soll. Zu diesem Zweck wurden zwei Probenvorbereitungsstrategien und zwei komplementäre LC Bedingungen untersucht, wobei eine saure mobile Phase (0,1% TFA) mit einem neuartigen Ansatz unter der Verwendung einer b
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Barclay, Victoria K. H. "Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171550.

Texto completo
Resumen
This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. A method was also developed for the achiral compounds, diazepam and nordiazepam. The LC-MS/MS methods were validated by the use of the isotope-labeled compounds. As these isotope-labe
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Wabuyele, Simuli Lindah. "DEVELOPMENT OF LC-MS/MS METHODS FOR QUANTITATIVE ANALYSIS OF PLANT-DERIVED ANTICANCER AGENT AND SYNTHETIC ESTROGEN IN COMPLEX MATRICES." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1400262843.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Fujisawa, Alma. "Development of chemical labeling methods for organelle molecule analysis." Kyoto University, 2019. http://hdl.handle.net/2433/243315.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
11

Pingeon, Marine. "Development and validation of analytical methods for therapeutic drug monitoring." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4509.

Texto completo
Resumen
2017 - 2018<br>The U.S. Food and Drug Administration defines as Precision or Personalized Medicine (PM) an innovative therapeutic approach that tailors therapy and prevention on patients based on inter-individual variabilities in molecular or environmental features and in lifestyles. The major goals of PM are to maximize treatment efficacy and to reduce cost, toxicities and therapy failure rates by early identification of patients who might benefit or not of a specific treatment. In this scenario, therapeutic drug monitoring (TDM) is an important laboratory tool for PM because of the poss
Los estilos APA, Harvard, Vancouver, ISO, etc.
12

Wilson, Michael Andrew. "Analysis of complex distributions of bacteriochlorophylls : development and application of HPLC and LC-MS methods." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422530.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
13

Strömqvist, Malin. "Development of quantitative methods for the determination of vemurafenib and its metabolites in human plasma." Thesis, Linköpings universitet, Kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110076.

Texto completo
Resumen
Vemurafenib is a potent serine/threonine kinase inhibitor and is registered as Zelboraf® for the treatment of metastatic melanomas harboring BRAFV600E mutations. There is a large individual variation in drug response and the side effects observed among patients treated with Zelboraf® has proven to be severe.  LC-MS/MS methods were developed to measure vemurafenib and its metabolites in human plasma for prediction of treatment outcome and side effects in order to individualize treatment with Zelboraf®.  A novel, rapid quantification method was developed for vemurafenib using a stable isotope la
Los estilos APA, Harvard, Vancouver, ISO, etc.
14

Upite, Ruta, Susanna Wärmegård, Casper Tiger, Nordén Anna Ivert, Temis Martinez, and Viktor Umenius. "Immunoassays or LC-MS/MS? : A Comparison Revealing the Properties of Modern Methods for Insulin, Pro-insulin, C-peptide and Glucagon Quantification." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384690.

Texto completo
Resumen
The purpose of this report is to compare seven different methods for biomarker detection and quantification based on previously published papers. The methods investigated are ELISA, LC-MS/MS, UPLC-MS/MS, LC-IM/MS, IA-LC-MS/MS, MSIA-HR/AM, HTRF and AlphaLISA ® . The focus lies on biomarkers relevant for diabetes, obesity and cardiovascular diseases.Namely insulin, proinsulin, glucagon and C-peptide. Particular significance is assigned to the comparison of the currently widest used method, ELISA, with various types of LC-MS/MS. The report concludes ELISA being superior to LC-MS/MS methods in ter
Los estilos APA, Harvard, Vancouver, ISO, etc.
15

Ly, Tuan Kiet. "Development of analytical methods of multi-pesticide residues for controlling the tea quality, from tea plantation to consumer." Thesis, Toulouse, INPT, 2020. http://www.theses.fr/2020INPT0059.

Texto completo
Resumen
Le thé est la deuxième boisson la plus consommée au monde, dépassé uniquement par l'eau, en raison de ses bienfaits pour la santé. Cependant, en raison des pratiques de culture en monoculture, l'utilisation de pesticides pendant la culture du thé est courante. Au fil du temps, le nombre de pesticides utilisés a augmenté et, pour protéger la santé des consommateurs, de nombreux pays et régions ont établi des limites maximales de résidus de pesticides pour une variété d'aliments et de boissons, y compris le thé. Par exemple, l'Union européenne (UE) a fixé les limites maximales de résidus (LMR) p
Los estilos APA, Harvard, Vancouver, ISO, etc.
16

Wiegandt, Alena [Verfasser], and Bernd [Akademischer Betreuer] Meyer. "New Methods for Characterization of N-type Glycosylation of Proteins by Integration of LC-MS/MS and NMR / Alena Wiegandt ; Betreuer: Bernd Meyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1209272407/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
17

Bärenfänger, Melissa [Verfasser], and Bernd [Akademischer Betreuer] Meyer. "New Methods for the Characterization of Human Glycoproteins by LC-MS/MStechniques / Melissa Bärenfänger ; Betreuer: Bernd Meyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1205070834/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
18

ZANCHETTA, MARTINA. "Development of analytical methods for therapeutic drug monitoring of first- and second-line therapies for hepatocellular carcinoma." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3015402.

Texto completo
Resumen
Il monitoraggio terapeutico dei farmaci (TDM) è la pratica clinica di misurazione di un farmaco specifico a intervalli di tempo definiti per mantenere le concentrazioni plasmatiche all'interno di una finestra terapeutica mirata, per massimizzare l'efficacia e ridurre al minimo la tossicità. Per rendere fattibile questo approccio sono necessari metodi analitici robusti, sensibili e riproducibili per quantificare i farmaci antitumorali nei fluidi biologici. Questo progetto di dottorato si è concentrato su quattro farmaci antitumorali orali utilizzati per il trattamento di pazienti con HCC avanza
Los estilos APA, Harvard, Vancouver, ISO, etc.
19

Huang, Qianyang. "Development and Validation of UPLC/MS/MS Methods for Quantification of Gangliosides in the Clinical Study of Ganglioside GM3 Synthase Deficiency." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1472042152.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
20

Lehto, T. (Tiina). "Evaluation of new laboratory methods for routine use." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526210759.

Texto completo
Resumen
Abstract Laboratory medicine is under constant pressure from changes in the operating environment. Organisational changes and tendering processes have led to a trend towards shorter turn-around times and more cost-effective choices. Analysis tools that were previously only available at research laboratories, such as the mass spectrometer and polymerace chain reaction (PCR), have now made their way to university hospital laboratories and even mid-sized laboratories. Organisational changes have increased the need to monitor the pre-analytical steps. The specimen can be drawn from the patient in
Los estilos APA, Harvard, Vancouver, ISO, etc.
21

De, Lama Valderrama Noelia Milagros. "Development of new mass spectrometry methods for the characterization of protein impurities in therapeutic antibodies." Electronic Thesis or Diss., Strasbourg, 2025. http://www.theses.fr/2025STRAF008.

Texto completo
Resumen
Les protéines de cellule hôte (HCPs) sont des impuretés indésirables dans la production d’anticorps monoclonaux (mAbs), pouvant compromettre la sécurité, l’efficacité et la stabilité des traitements. Bien que l’ELISA soit couramment utilisée, elle présente des limites de couverture. Cette thèse explore des méthodes complémentaires basées sur la spectrométrie de masse. Une approche d’immuno-capture permet de détecter les HCPs non immune-réactifs, tandis que des workflows LC-MS/MS avancés avec des peptide standards offrent une quantification plus précise. Ces stratégies visent à améliorer le con
Los estilos APA, Harvard, Vancouver, ISO, etc.
22

Zeng, Chun. "The Role of RNASE L in Type I Diabetes and Development of Quantitative LC-MS/MS Methods for the Pharmacological Studies of Anti-Cancer Drug Candidates." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1473178407.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
23

Jakob-Rodamer, Verena [Verfasser], Fritz [Gutachter] Sörgel, Ulrike [Gutachter] Holzgrabe, and Petra [Gutachter] Högger. "Development and validation of LC-MS/MS methods to determine PK/PD parameters of anti-infectives / Verena Jakob-Rodamer. Gutachter: Fritz Sörgel ; Ulrike Holzgrabe ; Petra Högger." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1112040285/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
24

Archibald, Timothy L., Derek Edward Murrell, and Stacy D. Brown. "Chromatographic Methods in Hiv Medicine: Application to Therapeutic Drug Monitoring." Digital Commons @ East Tennessee State University, 2018. https://doi.org/10.1002/bmc.4170.

Texto completo
Resumen
HIV antiretroviral therapy spans several different drug classes, meant to combat various aspects of viral infection and replication. Many authors have argued the benefits of therapeutic drug monitoring (TDM) for the HIV patient including compliance assurance and assessment of appropriate drug concentrations; however, the array of drug chemistries and combinations makes TDM an arduous task. HPLC-UV and LC-MS/MS are both frequent instruments for the quantification of HIV drugs in biological matrices with investigators striving to balance sensitivity and affordability. Plasma, the dominant matrix
Los estilos APA, Harvard, Vancouver, ISO, etc.
25

Rodamer, Michael [Verfasser], and Ulrike [Akademischer Betreuer] Holzgrabe. "Development of practice-oriented LC-MS, MS methods for the determination of important drugs and their application for building PK, PD concepts / Michael Rodamer. Betreuer: Ulrike Holzgrabe." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/102252268X/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
26

NOBILE, MARIA. "DEVELOPMENT AND VALIDATION OF METHODS FOR THE DETECTION OF RESIDUES IN UNCONVENTIONAL AND INNOVATIVE MATRICES THROUGH LC-MS/MS ANALYSES FOR SAFETY OF FOOD OF ANIMAL ORIGIN." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/547683.

Texto completo
Resumen
Successful animal growth depends on a combination of many factors related to health, management and nutrition. The use of veterinary drugs in food-producing animals for therapeutic purposes is regulated (corticosteroids, antibiotics) or banned (anabolic steroids) in the European Union; however, their use as growth promoters cannot be excluded. Moreover, the eventual presence of residues in food constitutes a fraud and a health issue for the consumers. For these reasons the need to find new accumulation matrices and new sensitive, specific and robust methods that are able to reveal the presence
Los estilos APA, Harvard, Vancouver, ISO, etc.
27

Van, Huyssteen Este. "Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology / E. van Huyssteen." Thesis, North-West University, 2010. http://hdl.handle.net/10394/5050.

Texto completo
Resumen
Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which translate to low bioavailability. Mefloquine is eliminated slowly with a terminal elimination half-life of approximately 20 days and has neuropsychiatric side effects. Novel drug delivery systems have been utilised to optimise chemotherapy with currently available antimalarial drugs. Pheroid™ technology is a patented drug delivery system which has the ability to capture, tra
Los estilos APA, Harvard, Vancouver, ISO, etc.
28

Desai, Meera Jay. "Development of Chiral LC-MS Methods for small Molecules and Their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies." Ames, Iowa : Oak Ridge, Tenn. : Ames Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/837266-GaBf1y/webviewable/.

Texto completo
Resumen
Thesis (Ph.D.); Submitted to Iowa State Univ., Ames, IA (US); 19 Dec 2004.<br>Published through the Information Bridge: DOE Scientific and Technical Information. "IS-T 2134" Meera Jay Desai. US Department of Energy 12/19/2004. Report is also available in paper and microfiche from NTIS.
Los estilos APA, Harvard, Vancouver, ISO, etc.
29

Mejait, Anouar. "Evaluation of the environmental fate and impact of organic contaminants using innovative approach coupling high-throughput methods." Electronic Thesis or Diss., Perpignan, 2024. http://www.theses.fr/2024PERP0034.

Texto completo
Resumen
Les contaminants organiques sont des substances nocives présentes dans l'environnement qui peuvent affecter la santé humaine et les écosystèmes. Parmi eux, les composés pharmaceutiques et les pesticides sont liés à de nombreuses maladies chez l'homme. Ils peuvent également affecter des espèces non-cibles dans l'environnement. Dans le cas des pesticides, largement utilisés en agriculture, des alternatives sont à l'étude. Les biopesticides, qui sont des substances complexes dérivées de sources naturelles, représentent une alternative aux pesticides. Ils sont présumés moins nocifs ; cependant, le
Los estilos APA, Harvard, Vancouver, ISO, etc.
30

Abbas, Ioana [Verfasser], Michael [Gutachter] Weller, Maria [Gutachter] Montes-Bayón, and Michael [Gutachter] Linscheid. "Development of LC-MS/MS methods for the quantitative determination of hepcidin-25, a key regulator of iron metabolism / Ioana Abbas ; Gutachter: Michael Weller, Maria Montes-Bayón, Michael Linscheid." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185579397/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
31

Clarke, Rosemary Emily Jane. "The development and application of liquid chromatography/tandem mass spectrometry (LC-MS/MS) methods for the quantification of the gut hormones peptide YY, glucagon-like peptide-1 and oxyntomodulin." Thesis, Imperial College London, 2018. http://hdl.handle.net/10044/1/59038.

Texto completo
Resumen
Our current understanding of gut hormones is limited by our inability to measure their concentration with sufficient specificity and sensitivity. Liquid chromatography tandem mass spectrometry (LC-MS/MS) has already been applied to glucagon quantification and offers a potential solution. This PhD aimed to develop LC-MS/MS methods for the quantification of five peptide gut hormones: glucagon-like peptide-1 (GLP-1) 7-36 amide, GLP-1 9-36 amide, oxyntomodulin, peptide YY (PYY) 1-36 and PYY 3-36. The optimised extraction of the gut hormones from plasma comprised protein precipitation, followed by
Los estilos APA, Harvard, Vancouver, ISO, etc.
32

Smit, Michiel Johannes. "Development and validation of selective and sensitive LC-MS/MS Methods for determination of para-aminosalicyclic acid and cycloserine/terizidone applicable to clinical studies for the treatment of tuberculosis." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29814.

Texto completo
Resumen
A method was validated for the quantification of para-aminosalicylic acid (PAS) in human plasma. The technique consisted of a protein precipitation extraction, followed by high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) detection. Rilmenidine was used as the internal standard (ISTD). Analyte mean extraction yields determined were ~100.3% (CV % = 3.3). The extraction procedure was followed by liquid chromatographic separation using a Phenomenex Synergi Hydro-RP (150 x 2.0 mm, 4µm) analytical column. An isocratic mobile phase containing methanol, water and formic
Los estilos APA, Harvard, Vancouver, ISO, etc.
33

Maria, Aoun. "Development of Analytical methods for the evaluation of the impact of phosphate fertilizer industry on marine environment." Thesis, Pau, 2014. http://www.theses.fr/2014PAUU3033.

Texto completo
Resumen
Développement de méthodes analytiques pour l’évaluation de l'impact de l'industrie de fertilisants chimiques sur le milieu marin<br>Development of Analytical methods for the evaluation of the impact of phosphate fertilizer industry on marine environment
Los estilos APA, Harvard, Vancouver, ISO, etc.
34

The, Matthew. "Statistical and machine learning methods to analyze large-scale mass spectrometry data." Licentiate thesis, KTH, Genteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185149.

Texto completo
Resumen
As in many other fields, biology is faced with enormous amounts ofdata that contains valuable information that is yet to be extracted. The field of proteomics, the study of proteins, has the luxury of having large repositories containing data from tandem mass-spectrometry experiments, readily accessible for everyone who is interested. At the same time, there is still a lot to discover about proteins as the main actors in cell processes and cell signaling. In this thesis, we explore several methods to extract more information from the available data using methods from statistics and machine lea
Los estilos APA, Harvard, Vancouver, ISO, etc.
35

Barreras, Garcia Alvaro. "Food safety: developement of new methods for marine algal toxins detection." Doctoral thesis, Università degli studi di Trieste, 2013. http://hdl.handle.net/10077/8644.

Texto completo
Resumen
2011/2012<br>SUMMARY Biotoxins produced by harmful algae during their proliferation can be accumulated by filter feeding organisms, such as bivalve shellfish, within their flesh. Furthermore, these toxins gradually are transferred to the higher trophic levels in the food chain, posing a threat to human health, after consumption of contaminated seafood. Filter-feeding invertebrates are organisms in which the toxin accumulation is a well-known phenomenon, especially during harmful algal blooms. Mussels, cockles, oysters, and scallops feed on toxic dinoflagellates, transferring them from the
Los estilos APA, Harvard, Vancouver, ISO, etc.
36

Rapholo, Akanyang Annah Faithful. "Comparing diene derivatisation methods of dry blood spot samples for vitamin D metabolites quantification by liquid chromatography-tandem mass spectrometry." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/63038.

Texto completo
Resumen
This dissertation describes the elucidation and implementation of derivatisation in the quantification of biologically active vitamin D metabolites in limited volume serum and dry blood spot samples (DBS) using the liquid chromatography tandem-mass spectrometry (LC-MS/MS) analytical technique. This manuscript describes in detail the development and validation of an analytical methodology, highlighting the role derivatisation and mass spectrometry plays in the structural characterisation and quantification of vitamin D metabolites. The first chapter reviews comprehensively, the history o
Los estilos APA, Harvard, Vancouver, ISO, etc.
37

Westberg, Emelie. "Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates." Doctoral thesis, Stockholms universitet, Institutionen för material- och miljökemi (MMK), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-110490.

Texto completo
Resumen
This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. Analysis by MS methods of stable adducts offers the specificity and accuracy required to generate data on internal dose useful in risk estimation. The primary aim was to develop a method for quantification by LC/MS of bulky adducts to serum albumin (S
Los estilos APA, Harvard, Vancouver, ISO, etc.
38

GOSETTI, FABIO. "Methods of analysis and control in food chemistry by chromatographic techniques with UV-Vis and mass spectrometry detections." Doctoral thesis, Università degli Studi del Piemonte Orientale, 2005. http://hdl.handle.net/10281/255650.

Texto completo
Resumen
Investigation in food science and technology, both by the food industry and governmental agencies, is based on the evaluation of food composition and characteristics. All food products require analysis as part of a quality management program that involves the development, the production processes and the control of the commercial product. The chemical composition and physical properties of food are necessary to evaluate the nutritive value, the functional characteristics and the acceptability of the food product. The nature of the sample and the specific use of the analysis dictate the choice
Los estilos APA, Harvard, Vancouver, ISO, etc.
39

Höfig, Carolin. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16645.

Texto completo
Resumen
Thyronamine (TAM) sind eine neue Molekülklasse, die endokrinologische und metabolische Prozesse miteinander vereinen. Der biologisch aktive Metabolit 3-Iod-L-Thyronamin (3-T1AM) wird durch eine kombinierte Deiodierung und Decarboxylierung von Schilddrüsenhormonen (TH) gebildet. Existierende Methoden zum Nachweis und zur Quantifizierung von 3-T1AM im menschlichen Serum sind immer noch umstritten. Auch die an der Biosynthese vermutlich beteiligte TH-Decarboxylase konnte noch nicht identifiziert werden. Für die Identifizierung und Quantifizierung von TH und TAM Profilen wurde die Flüssigchromatog
Los estilos APA, Harvard, Vancouver, ISO, etc.
40

Alothaim, Ibrahim. "Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=29531.

Texto completo
Resumen
Inflammatory bowel disease (IBD) is a chronic inflammation of all parts of the gastrointestinal tract and is represented by two major variations, ulcerative colitis (UC) and Crohn's disease (CD). It is diagnosed based on the pattern of inflammation. In order to understand the pathology of the disease better urine and saliva samples were collected from patients with IBD, patients in remission and a control group. The metabolomes of the urine and saliva samples were profiled by carrying out chromatography on a ZICpHILIC column in combination with high resolution mass spectrometry. It was possibl
Los estilos APA, Harvard, Vancouver, ISO, etc.
41

Zamani, Leila. "Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics." Doctoral thesis, Stockholms universitet, Institutionen för analytisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-28921.

Texto completo
Resumen
This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. Metabolic fingerprinting and multivariate data analysis (MVDA) can also facilitate early diagnosis of diseases and the effects and toxicity of drugs. Currently, several protein drugs are available on the gl
Los estilos APA, Harvard, Vancouver, ISO, etc.
42

Goodpaster, Aaron M. "Statistical Analysis Methods Development for Nuclear Magnetic Resonance and Liquid Chromatography/Mass Spectroscopy Based Metabonomics Research." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1312317652.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
43

Kim, Dong Hyun. "Investigation of HIV anti-viral drug effect on HPV16 E6 expressing cervical carcinoma cells using advanced metabolomics methods." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-hiv-antiviral-drug-effect-on-hpv16-e6-expressing-cervical-carcinoma-cells-using-advanced-metabolomics-methods(d52b3b66-2a7b-4577-a334-b74bc12b27cc).html.

Texto completo
Resumen
Metabolomics approaches have recently been used to understand the complex molecular interactions of biological systems. One popular area in which these methods are being developed is to understand the biochemical changes during abiotic and biotic stresses; for example, how a cell may respond to a drug. Since metabolites are the end products of gene expression, these can be used to indicate the result of the activities and interaction of the cell or organism with its environment. The investigation of the level and compositional changes of metabolites against metabolic stresses such as chemother
Los estilos APA, Harvard, Vancouver, ISO, etc.
44

Ullah, Shahid. "Improved analytical methods for perfluoroalkyl acids (PFAAs) and their precursors – a focus on human dietary exposure." Doctoral thesis, Stockholms universitet, Institutionen för tillämpad miljövetenskap (ITM), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93719.

Texto completo
Resumen
Per- and polyfluoroalkyl substances are a large group of global environmental contaminants. They can be divided into two sub-groups, 1) perfluoroalkyl acids (PFAAs) and 2) so called precursors, i.e. compounds that can potentially be transformed to form PFAAs. PFAAs are today ubiquitous in wildlife and humans. Food and drinking water are assumed to be the dominant human exposure pathways for PFAAs. The main aim of this doctoral thesis was to develop highly sensitive and fully validated analytical methods for the determination of a range of PFAAs and selected precursors in dietary samples. The m
Los estilos APA, Harvard, Vancouver, ISO, etc.
45

Tollbäck, Johanna. "New methods for determination of airborne pollutants : Focus on tetrabromobisphenol A, organophosphate triesters and polycyclic aromatic hydrocarbons." Doctoral thesis, Stockholms universitet, Institutionen för analytisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-26700.

Texto completo
Resumen
The work presented in this thesis concerns the development and evaluation of new methods of sampling and analysis of organic pollutants in the indoor and outdoor environment. In Paper I, the development of a new method was reported for the determination of the brominated flame retardant tetrabromobisphenol A (TBBPA) in air using sampling with glass fiber filter and polyurethane foam (PUF), ultrasonic solvent extraction and liquid chromatography coupled to electrospray ionisation mass spectrometry (LC-ESI/MS). The MS fragmentation mechanism of TBBPA was thoroughly investigated and different acq
Los estilos APA, Harvard, Vancouver, ISO, etc.
46

Spáčil, Zdeněk. "Mass Spectrometry of Biologically Active Small Molecules : Focusing on polyphenols, alkaloids and amino acids." Doctoral thesis, Stockholms universitet, Institutionen för analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-33233.

Texto completo
Resumen
The foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols (PPs), alkaloids and amino acids published in five appended studies are presented and discussed. High efficiency and well understood principles make LC the method of choice for separating analytes in many kinds of scientific investigations. Moreover, when LC is coupled to an MS instrument, analytes are separated in two stages:
Los estilos APA, Harvard, Vancouver, ISO, etc.
47

Höfig, Carolin [Verfasser], Werner [Akademischer Betreuer] Kloas, Josef [Akademischer Betreuer] Köhrle, and Dagmar [Akademischer Betreuer] Führer-Sakel. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis / Carolin Höfig. Gutachter: Werner Kloas ; Josef Köhrle ; Dagmar Führer-Sakel." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://d-nb.info/1029763844/34.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
48

Carvalho, Jose Joao. "Immunochemical and chromatographic methods for two anthropogenic markers of contamination in surface waters." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16420.

Texto completo
Resumen
Koffein (1,3,7-Trimethylxanthin) und Coprostanol (5beta-cholestan-3beta-ol) wurden im Berliner Oberflächenwasser nachgewiesen. Ihre Konzentrationen korrelierten mit dem Verunreinigungsgrad der Proben, was nahelegt, dass sie sich als Marker für menschliche Aktivität eignen. Bemerkenswerterweise wurde Koffein in jeder einzelnen Oberflächenwasserprobe oberhalb der Bestimmungsgrenze von 0,025 µg/L gefunden. Um Oberflächenwasserproben in größeren Serien zu untersuchen, war die Entwicklung zweier neuer Methoden erforderlich: ein Immunoassay, basierend auf einem monoklonalen Antikörper für Koffein u
Los estilos APA, Harvard, Vancouver, ISO, etc.
49

Utami, Wahyu. "Ion pairing LC-MS/MS method for analysis of intracellular phosphorylated metabolites." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30566/.

Texto completo
Resumen
Nucleoside analogues have been extensively used in medication. The nucleoside analogue cordycepin is the principal bioactive compound found in the caterpillar fungi (Cordyceps and Ophiocordyceps). It has been shown to have biological activity, including anti-inflammatory, immunomodulatory and anti-proliferative activity in many kinds of malignant cells. Intracellular drug interactions at the nucleotide level can be explained by understanding the intracellular metabolism of nucleoside analogues as well as their plasma metabolism since their efficacy of therapy or toxicity does not associate wit
Los estilos APA, Harvard, Vancouver, ISO, etc.
50

Yacoub, Kimberly. "Development of ESI-LC-MS Method for Drug Analysis." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1524040258129489.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
También puede estar interesado en las bibliografías sobre el tema "LC-MS methods" para otros tipos de fuentes:
Artículos de revistas Libros
Ofrecemos descuentos en todos los planes premium para autores cuyas obras están incluidas en selecciones literarias temáticas. ¡Contáctenos para obtener un código promocional único!

Pasar a la bibliografía