Tesis sobre el tema "Kinases"
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Chetoui, Nizar. "Caractérisation du rôle de la protéine kinase MEK1 dans les voies de transduction des MAP kinases". Thesis, Université Laval, 2005. http://www.theses.ulaval.ca/2005/22589/22589.pdf.
Texto completoGopalbhai, Kailesh. "Régulation négative des MAP kinase kinases par phosphorylation /". [Montréal] : Université de Montréal, 2003. http://wwwlib.umi.com/cr/umontreal/fullcit?pNQ92759.
Texto completo"Thèse présentée à la Faculté des études supérieures en vue de l'obtention du grade de Philosophiae Doctor en Pharmacologie" Version électronique également disponible sur Internet.
Jean, Steve. "Caractérisation fonctionnelle de nouveaux partenaires protéiques des kinases xPAK1 et xMLK2 chez Xenopus laevis". Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25722/25722.pdf.
Texto completoBeggs, James. "The MAP-kinase interacting kinases (Mnks) as targets in cancer". Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/390651/.
Texto completoGatesman, Ammer Amanda. "PKCalpha direct cSrc activation and podosome formation through the adaptor protein AFAP-110". Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3762.
Texto completoTitle from document title page. Document formatted into pages; contains vii, 350 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 322-346).
Gravel, Mathieu. "Rôle du gène Mek1 dans la différenciation des trophoblastes souches et lors du développement embryonnaire". Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25697/25697.pdf.
Texto completoWaskiewicz, Andrew Jan. "Mitogen-activated protein kinase : evolutionary conservation and activation of downstream kinases /". Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9216.
Texto completoSimard-Bisson, Carolyne. "Rôles de la "Dual leucine zipper-bearing Kinase" dans la réorganisation des microtubules et la différenciation des kératinocytes humains". Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/28201.
Texto completoSkin barrier function greatly depends on proper keratinocyte differentiation in the epidermis. During this process, many changes occur within the cell such as decrease in cell proliferation, cytoskeleton reorganization, changes in gene expression, nucleus and organelles elimination as well as cornified envelope formation. Keratinocyte differentiation must be finely orchestrated since misregulation of this process may lead to pathological conditions. The Dual Leucine zipper-bearing Kinase (DLK) is a Mitogen-Activated Protein Kinase Kinase Kinase showing a strong expression in the granular layer, the last layer composed of living cells before reaching the cornified layer. Previous studies revealed DLK capacity to induce keratinocyte terminal differentiation process. However, how DLK promotes such an event remains unknown. The main objective of this thesis is to identify mechanisms and potential effectors of the DLK-induced keratinocyte differentiation. Our hypothesis is that DLK is required for keratinocyte differentiation by promoting microtubule stabilization as well as the expression or the activity of transcription factors involved in this process. In order to test our hypothesis, a tissue-engineered skin (TES) model with a reduced DLK expression was produced using a RNA interference approach. Impaired distribution of cornified envelope proteins such as filaggrin and transglutaminase 1 as well as reduced granular and cornified layers were observed in TES with reduced DLK expression. In those samples, immunofluorescence and electron microscopy analyses pointed out desmosomal and tight junctional defects suggesting a role for DLK in the maintenance of these types of cell junctions. The impact of DLK expression on microtubules was also studied in TES with reduced DLK expression and in keratinocytes in culture overexpressing DLK following gene transduction using adenoviral vectors. These studies led to the conclusion that DLK not only promotes but is also required for microtubules reorganization and stabilization to cell periphery. To explain DLK capacity to induce such a process, effects of DLK depletion or overexpression on microtubule regulators such as LIS1 and HSP27 were investigated by immunofluorescence staining. These analyses revealed that DLK induces and is required for LIS1 and HSP27 relocalization to cell periphery. In additional studies, our results show that DLK expression in normal human keratinocytes in culture not only promotes HSP27 distribution to cell periphery but also induces HSP27 insolubilization and phosphorylation in an ERK-dependent manner. In order to more precisely define the role of microtubules in keratinocyte differentiation process, TES were treated with nocodazole, a microtubule depolymerizing agent. The effect of such a treatment was to reproduce the phenotype of DLK-depleted TES suggesting that microtubules are important effectors of DLK-induced keratinocyte differentiation. In an attempt to describe the impact of DLK on global gene expression, RNA samples of DLK-depleted TES were studied using microarray analyses. This approach revealed a reduction in the expression of many genes coding for cornified envelope proteins. Reductions of c-Jun and C/EBPα immunofluorescence staining were also noted in TES with a reduced DLK expression suggesting this kinase as a c-Jun and C/EBPα regulator in the context of keratinocyte differentiation. Globally, our works show that DLK is required for keratinocyte differentiation since it promotes microtubule reorganization to cell periphery, desmosomes and tight junction consolidation as well as c-Jun and C/EBPα localization to the nucleus.
Guillemette, Stéphanie. "La contribution de Mek2 dans le développement du placenta murin". Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24208/24208.pdf.
Texto completoNadeau, Philippe. "Régulation de la MAP3-kinase Ask1 par oxydoréduction". Doctoral thesis, Université Laval, 2009. http://hdl.handle.net/20.500.11794/21223.
Texto completoDennis, Patrick B. (Patrick Brian). "Autophosphorylation and Autoactivation of an S6/H4 Kinase Isolated From Human Placenta". Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc279364/.
Texto completoGruszczyk, Jakub. "Structural analysis of bacterial protein tyrosine kinases (by-kinases) and their substrates". Paris 11, 2010. http://www.theses.fr/2010PA112135.
Texto completoAtypical bacterial tyrosine kinases (BY-kinases) have been identified as part of a multiprotein transmembrane complex responsible of the biosynthesis and export of capsular polysaccharides. BY-kinases autophosphorylate on a C-terminal tyrosine cluster and phosphorylate endogenous bacterial proteins like UDP-sugar dehydrogenases involved in the synthesis of exopolysaccharide precursors. Available structural and functional data raised the question of the conservation of the oligomerization state and of the autophosphorylation mechanism between BY-kinases from proteobacteria and firmicutes. I thus solved the crystal structure of the cytoplasmic domain of the BY-kinase Wzc from E. Coli. This new structure shows that, like the BY-kinase CapAB from the firmicute S. Aureus, Wzc forms an octameric ring explaining the intermolecular autophosphorylation mechanism. Fluorimetric affinity measurements further allowed me to show that the internal tyrosine Y569, initially supposed to regulate tyrosine-cluster trans-autophosphorylation, is directly involved in nucleotide binding. We also show that a flexible loop rich in basic residues plays an essential role in capsule synthesis, most probably through interaction with other proteins involved in this process. Moreover, I solved the crystal structure of UDP-N-acetylmannosamine dehydrogenase CapO, the substrate of the BY-kinases CapAB from S. Aureus. The structure reveals the formation of a disulfide bridge between the catalytic cysteine C258 and residue C92 and the presence of potential phosphorylation sites, Y89 and Y264, close to these two cysteines. Mutational analysis is underway in order to elucidate the regulatory mechanism of this enzyme. Comparison with the structures of other members of this family of dehydrogenases also allows us to shed light on their specific substrate recognition
Mazharian, Alexandra. "Rôle complémentaire des MAP Kinases ERK2, p38 et JNK1 dans l'activation plaquettaire". Paris 7, 2007. http://www.theses.fr/2007PA077217.
Texto completoThe MAP Kinases belong to a serine/threonine kinase family that include the "Extracellular signal-Regulated Kinases" (ERKs), p38MAPKs and the "c-jun N-terminal Kinases" (JNKs). The study of the MAP Kinase in platelets allows identifying new targets and new rôles in particular in the haemostasis and thrombosis. In the first study, we describe complementary roles of ERK2 and p38MAPK in platelet adhésion and spreading over a collagen matrix. The role of ERK2 is dependent of blood flow and vWF/GPIb interaction. In contrast, the role of the p38MAFK in platelet adhesion is independent of blood flow and involved the α2β1 integrin. In the second study, we show the ERK2 and p38MAPK are involved in platelet spreading on a fibrinogen matrix after PAR4 stimulation. Activation of p38MAPK, required for actin polymerization, is dependent of ADP signalling through its receptor P2Y12, In contrast, ERK2, required for Myosin Light Chain phosphorylation, is dependent on integrin αllbβ3 outside-in signalling and the Rho pathway, Both MAP Kinases act on cytoskeleton rearrangement required for platelet spreading, Lastly, we show for the first time a role of JNKl in platelet aggregation and secretion induced by low concentrations of collagen. In addition, JNKl is required for thrombus growth at high shear involving activation of integrin αllbβ3 and vWF/GPIb interaction. Finally, in vivo, JNKl is involved in a mouse model of arterial thrombosis. In conclusions, our works bring us new knowledge as for the roles of MAP Kinases ERK2, p38MAPK and JNKl in the different stages of platelet activation
Bissonauth, Vickram. "Rôle essentiel de Mek1 dans le développement des tissus extra embryonnaires de la souris". Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23624/23624.pdf.
Texto completoCowan, Richard H. "Refolding of protein kinases". Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3133/.
Texto completoGold, Matthew. "Targeting AGC protein kinases". Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504788.
Texto completoWalker, Valerie Glynis. "Pl3-kinase mediates cSrc activation and podosome formation through the adaptor protein, AFAP-110, in response to PKC[alpha] activation". Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5191.
Texto completoTitle from document title page. Document formatted into pages; contains viii, 306 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Burns, Christopher John. "Tyrosine kinases and mitogen-activated protein kinases : roles in pancreatic β-cell function". Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313990.
Texto completoVaglio, Philippe. "Etude de la relation structure-fonction de la protéine kinase CK2 par mutagenèse dirigée des résidus basiques conservés". Montpellier 1, 1996. http://www.theses.fr/1996MON1T029.
Texto completoRaman, Malavika. "Identification of intracellular signaling pathways regulated by the TAO family of mammalian STE20p kinases". Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=163.
Texto completoMurdoch, Fern E. (Fern Elizabeth). "Occurrence and Structure of an Activating Enzyme for an S6 Kinase Determined by Monoclonal Antibody Analysis". Thesis, North Texas State University, 1987. https://digital.library.unt.edu/ark:/67531/metadc798366/.
Texto completoYoon, Moon-Young. "Studies of the Mechanism of the Catalytic Subunit of cAMP Dependent Protein Kinase". Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc332161/.
Texto completoNadeau, Valérie. "Implication de MEK1 et MEK2 dans la morphogenèse du placenta de souris". Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/25734.
Texto completoThe mammalian genome contains two ERK/MAP kinase kinase genes, Mek1 and Mek2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. In the mouse, the loss of Mek1 function causes embryonic lethality, whereas Mek2 mutants survive with a normal lifespan, suggesting that Mek1 rescues the lack of Mek2 function. The first objective of my thesis was to clarify potential functions of Mek2 during mouse embryogenesis. To do, I have analyzed the loss of Mek2 function in the presence of Mek1 haploinsufficiency. Most Mek1+/-Mek2+/- embryos die during gestation from placenta defects affecting extra-embryonic tissues. Thus, even though Mek1 plays a predominant role, these results enlightened the function of Mek2 in placenta development. The histological characterization of Mek1+/-Mek2+/- placentas revealed a diminution of the vascularization and an aberrant formation of multinucleated trophoblast giant (MTG) cells. Genetic experiments on the SynT-II cellular lineage in vivo demonstrated that MTG cells derive from the aberrant SynT-II differentiation and that their formation results from a cell-autonomous effect. The second objective of my thesis was to determine in which cell types the ERK/MAPK activation is essential for placenta development. Genetic analyses combined with histological studies revealed that MTG formation resulted from the ectopic fusion between both layers of SynT, which normally participate in an independent way in the blood-placental barrier. The blood-placental barrier is constituted of a double layer of SynT and by the cells derived from the allantois, the endothelial cells and their perycites. The deletion of both Mek1 alleles in allantois-derived tissues in a Mek1+/-Mek2+/- placenta environment increases the penetrance and the expressivity of the MTG phenotype. These results demonstrate the role of the ERK/MAPK pathway in defined embryonic and extraembryonic cell populations for correct placenta formation. Using mouse genetics, we also demonstrated that the normal development of syncytiotrophoblasts type I into a thin layer of multinucleated cells depends on the presence of the syncytiotrophoblasts type II. Finally, the combined mutations of Mek1 and Mek2 genes alter the expression of several genes involved in cell fate specification, cell fusion and cell polarity that likely explain the underdeveloped placenta and the MTG phenotype seen in Mek1Mek2 mutants.
Sallam, Hatem. "Pharmacological and analytical studies of the cyclin dependent kinase inhibitors". Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-706-1/.
Texto completoGuthrie, Chris Raymond. "Neural specific isoforms of protein kinase A and the role of protein kinases in neural gene expression /". Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6258.
Texto completoBendjeddou, Lyamin. "Synthèse et évaluation biologique de nouveaux inhibiteurs de kinases : identification d‘inhibiteurs de kinases parasitaires". Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P615.
Texto completoPhosphorylation by protein kinases is one of the most important post-translational modification in cellular processes such as division, differentiation, proliferation and apoptosis. Kinase deregulation is associated with numerous diseases such as cancer or neurodegenerative diseases. Imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine were prepared to inhibit protein kinases involved in diseases targeted in the laboratory. The imidazo[1,2-b]pyridazines were synthesized to identify inhibitors of CLK1 and DYRK1A, potential targets in Alzheimer's disease. Among the imidazo[1,2-b]pyridazines synthesized, several molecules were found selective of DYRKs and CLKs, with IC50 < 100 nM. A structure-activity relationship based on the synthesis of 70 molecules, led to the identification of the structural bases of the selectivity. Products were also evaluated against parasite kinases. It was possible to identify some highly potent inhibitors on PfCLK1. The aim of second part of this thesis was to optimize the synthetic process to obtain imidazo[4,5-b]pyridines, which are close analogues of roscovitine. Derivatives had proved capable of inhibiting the formation of cysts in a cellular model of polycystic kidney disease. A seven-step synthesis has led to several grams of 3,5,7-trisubstituted imidazo[4,5-b]pyridine which is now available for evaluation in vivo
Alexander, Jes. "Roles for motifs of cell cycle regulating kinases beyond substrate selection of individual kinases". Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45313.
Texto completoIncludes bibliographical references.
Errors in the cell cycle, particularly during mitosis, have recently been implicated in tumorigenesis and cancer formation. Several protein kinases, including the major mitotic kinases Cdkl, Aurora A, Aurora B, Nek2, and Plkl, and the Polo-like kinase (Plk) family, Plkl, Plk2, Plk3, and Plk4, are known to play important roles in the regulation of mitosis and other phases of the cell cycle to prevent such errors. However, the mechanisms underlying many of the roles of these kinases are unknown because the appropriate substrates have not been identified. To aid in substrate identification and to gain insight into the role of substrate specificity in the regulation of these kinases, we have determined the motifs of the major mitotic kinases and the Plk family of kinases by Positional Scanning Oriented Peptide Library Screening (PS-OPLS), which gives complete, unbiased motifs. The PS-OPLS motif of Plkl revealed a previously unreported specificity of Plkl leading to the identification of new candidate substrates, including p31/Comet, which is involved in the silencing of the spindle assembly checkpoint for anaphase onset. Additionally, the motifs and the localizations of the major mitotic kinases lead us to put forward a model potentially explaining how the major mitotic kinases, despite having overlapping localizations and access to the same sites on substrates, phosphorylate distinct sites. This model, if true, would suggest that the motifs and localizations of all of the major mitotic kinases coordinately direct the group of kinases to the appropriate substrates. The motifs of the Plk family reveal that Plk2 and Plk3 phosphorylate sites previously primed by phosphorylation by a tyrosine kinase, suggesting that these kinases may integrate tyrosine kinase and serine/threonine kinase signaling in a novel way.
(cont.) Finally, we find that Plk3 has a phosphorylation dependent toggle switch which changes the motif of the kinase. The result suggests that the motif of a kinase is not necessarily static, as was previously thought, and that the motif of certain kinases may be modulated for different roles. These results give us deeper insight into the function of kinases at the level of motifs, substrates, and the regulation of groups of kinases.
by Jes Alexander.
Ph.D.
Kragelj, Jaka. "Structure and dynamics of intrinsically disordered regions of MAPK signalling proteins". Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV060/document.
Texto completoProtein signal transduction pathways allow cells respond to and process signals from the environment. A group of such pathways, called mitogen-activated protein kinase (MAPK) signal transduction pathways, is well conserved in all eukaryotic cells and is involved in regulating many important cell processes. Long intrinsically disordered region (IDRs), present in many MAPKs, have remained structurally uncharacterised. The IDRs of MAPKs are especially important as they contain docking-site motifs which control the interactions between MAPK proteins themselves and also between MAPKs and other interacting proteins containing the same motifs. Nuclear magnetic resonance (NMR) spectroscopy in combination with other biophysical techniques was used to study IDRs of MAPKs. NMR spectroscopy is well suited for studying intrinsically disordered proteins (IDPs) at atomic-level resolution. NMR observables, such as for example chemical shifts and residual dipolar couplings, can be used together with ensemble selection methods to study residual structure in IDRs. Nuclear spin relaxation informs us about fast pico-nanosecond motions. NMR titrations and exchange spectroscopy techniques can be used to monitor kinetics of protein-protein interactions. The mechanistic insight into function of IDRs and motifs will contribute to understanding of how signal transduction pathways work
Le, Ly Thuy Tram. "Benzo[e]pryridoindolones, nouveaux inhibiteurs de kinases hydrosolubles à fort potentiel anti-prolifératif". Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV019/document.
Texto completoBenzo[e]pyridoindoles are novel potent inhibitors of aurora kinases. We performed a SAR study to improve their activity and water solubility. Amino-benzo[e]pyridoindolones were found to be potent hydrosoluble anti-proliferative molecules. They induced a massive arrest in mitosis, prevented histone H3 phosphorylation as well as disorganizing the mitotic spindles. Upon a delay, cells underwent binucleated and finally died. Taking into account their interesting preclinal characteristics, their efficiency towards xenografts in nude mice and their apparent safety in animals, these molecules are promising new anti-cancer drugs. They probably target a metabolic signaling pathway, besides aurora B inhibition. In addition to their possible applications, these inhibitors are tools for cell biology studies. C4, a low ATP affinity inhibitor of aurora B kinase, revealed that the basal activity of the kinase is required for histone H3 phosphorylation in prophase and for chromosome compaction in anaphase. These waves of activation/deactivation of the kinase, during mitosis, corresponded to different conformations of the passenger chromosomal complex
Holland, Pamela M. "Identification, interactions, and specificity of a novel MAP kinase kinase, MKK7 /". Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9262.
Texto completoSaurin, Adrian Thomas. "Protein kinases in myocardial protection". Thesis, King's College London (University of London), 2001. https://kclpure.kcl.ac.uk/portal/en/theses/protein-kinases-in-myocardial-protection(ba5e7b96-cf59-409a-b290-f18fec8be6b1).html.
Texto completoKaser, Matthew R. "Beryllium-sensitive nuclear protein kinases". Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:746dac6e-9609-42b7-a809-82ebc3dd465d.
Texto completoSamuels, Ivy S. "The roles of ERK₁ and ERK₂ MAP kinase in neural development and disease". Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1214495630.
Texto completoPrunier, Chloé. "Evaluation de l’efficacité thérapeutique d’un nouvel inhibiteur des LIM Kinases « Pyr1 » dans le cancer du sein". Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV052/document.
Texto completoBreast cancer is the most common diagnosed cancer in women worldwide with an increase of 20% and 14% in terms of incidence and mortality, respectively, in 2008 (GLOBOCAN, 2012). This increase is mainly due to the lack of therapeutics that target the development of metastasis responsible for 90% of cancer death. Moreover, the development of resistance to available chemotherapies limits their effectiveness. It's an urgent need to find new drugs that target the metastatic process and are efficient on resistant cancers.Our team has identified a new LIM Kinase (LIMK) inhibitor called “Pyr1”. LIM Kinases are implicated in the dynamic regulation of the actin and microtubule cytoskeleton. We previously published data showing that Pyr1 has an anti-mitotic and anti-migratory activity on a cervical cancer cell line. Moreover, a pilot in vivo study has shown that Pyr1 was efficient in a leukemia mouse model where it increases the lifespan of treated compared to control mice (Prudent et al., 2012).LIM Kinases have been shown to be overexpressed in breast cancer. Moreover the chemotherapeutical agents currently used for this kind of cancer belong to the class of taxanes (such as paclitaxel). Taxanes are cytotoxic compound that directly binds to microtubules and stabilizes them. Since Pyr1 treatment also results in microtubules stabilization, with a complete different mechanism of action, we have decided to investigate the anti-cancer effect of Pyr1 on breast cancer cell lines and xenografts, including paclitaxel resistant models.We showed that Pyr1 decreases primary tumor growth and reduces their size. Pyr1 is well tolerated and the anti-tumor effect is also observed on paclitaxel resistant models. We then studied Pyr1 effects on migration and invasion in vitro and in vivo. Intravital imaging of tumors showed that, whereas Pyr1 didn't slow down tumor cell migration, it induced a cell morphological change. Finally, Pyr1 does not affect metastasis spreading but prevents their growth.These results indicate that LIMK inhibitors, such as Pyr1, may represent a pharmacological alternative for taxanes resistant tumors. Moreover, they could be potent agents to reduce the size of metastasis
Grabbe, Caroline. "Protein tyrosine kinases and the regulation of signalling and adhesion in Drosophila melanogaster /". Doctoral thesis, Umeå : Umeå University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-971.
Texto completoMegidish, Tamar. "Sphingosine as second messenger, sphingosine dependent protein kinases and their substrates /". Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9285.
Texto completoCheng, Kai. "Identification of Pctaire1 as a p35-interacting protein and a novel substrate for Cdk5 /". View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20CHENG.
Texto completoIncludes bibliographical references (leaves 153-177). Also available in electronic version. Access restricted to campus users.
Kerkelä, R. (Risto). "Signaling pathways in myocyte hypertrophy:role of GATA4, mitogen-activated protein kinases and protein kinase C". Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269950.
Texto completoRiojas, Ramon Alberto. "Characterization of PDK1 regulation and function in the insulin-stimulated PI3-kinase pathway : a dissertation /". San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1372010131&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Texto completoJacq, Jérôme. "Synthèse et propriétés de nouveaux N-hydroxyimides polyaromatiques". Grenoble 1, 2009. http://www.theses.fr/2009GRE10187.
Texto completoA new route to 1,3-diarylisobenzofurans was developed with the goal to obtain new polyaromatic N-hydroxyimides. It involves the chemoselective addition of aryl magnesium reagents or aryl boronic acids to the aldehyde function of o-aroylbenzaldehydes, themselves obtained by a versatile Kotali reaction. This original method allowed the synthesis of various functionalized 1,3-diarylisobenzofurans and it was applied to the synthesis of 17 new polyaromatic N-hydroxyimides. Diversification reactions without protection of the N hydroxyimide function were successfully performed on these compounds. The biological activity of these compounds was evaluated and allowed the characterization of a new class of Protein Kinase CK2 inhibitors. In addition the synthesized compounds showed a good activity as aerobic oxidation catalysts. All products presented higher activity than NHPI and one of them showed catalytic properties similar to NHTTPI
Gandhi, Payal. "Characterization of the Parkinson's disease associated protein, leucine-rich repeat kinase 2 (LRRK2), as a Ras-related GTPase". Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1195574448.
Texto completoFeneyrolles, Clémence. "Identification et optimisation de nouvelles séries chimiques anti-kinases". Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20238.
Texto completoKinases are an important family among human proteins that include 518 identified members so far. They play key roles in the living functions such as proliferation, survival, migration of cells and apoptosis that make them of tremendous interest as potential and highly studied therapeutical targets. In particular, many cancers are associated with kinase dysfunction, overactivation, overexpression or repression. They are also involved in auto-immune and inflammatory diseases. Kinase inhibitors development is a challenge of modern medicinal chemistry, as the high conservation of their activity domain makes it difficult to design of specific inhibitors as well as mandatory given the broad spectrum of regulated phenomenon through their pathways. We hereby propose to design a specific inhibitor of a therapeutically validated kinase in the field of oncology. That kinase is however and despite the need not specifically targeted by any compound in the market so far. We previously obtained a small and highly derivatizable hit that we decided to optimize step by step in order to obtain new chemical entities of high potential toward that specific kinase
Nemeth, Joseph. "Design and synthesis of chemical probes for the protein kinase B PH domain". Thesis, St Andrews, 2008. http://hdl.handle.net/10023/572.
Texto completoLindzen, Eric Crandall. "Cloning, sequencing, molecular characterization and expression of a cDNA encoding CRK, an atypical protein kinase homologous to plant calcium-dependent protein kinases". Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/25639.
Texto completoSamiei, Mitra. "Characterization of protein kinases in platelets". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/NQ46416.pdf.
Texto completoPage, Timothy C. M. "Mechanism based inhibitors of tyrosine kinases". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260163.
Texto completoKristiansson, Helena. "Enhancing the promiscuity of sugar kinases". Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579758.
Texto completo魏燕萍 y Yin-ping Ngai. "p21-activated kinases in endometrial carcinoma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40738528.
Texto completoKitsios, Georgios. "Characterization of Arabidopsis cyclin dependent kinases". Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426634.
Texto completoChen, Yiyuan. "Regulation studies on human pyruvate kinases". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33175.
Texto completo