Artículos de revistas: "Jin tian"

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Wei, Lian Yu, Hao Li, Jin Liang Zhang y Shi Bin Ma. "Study on Semi-Rigid Road Base Asphalt Pavement Typical Structure of Town Roads". Applied Mechanics and Materials 178-181 (mayo de 2012): 1426–29. http://dx.doi.org/10.4028/www.scientific.net/amm.178-181.1426.

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In this paper, authors analyzed the semi-rigid road base asphalt pavement of towns and studied the optimum design methods of it, combining characteristics of town roads, considering natural conditions, vehicle axle,materialsupply,construction techniques, maintenance, transportation and so on, referring to design experiences of asphalt pavement in Tian Jin area, through indoor and outdoor experiments, applying math methods. In addition,optimum pavement structure function and calculating methods is given out, asphalt pavement structure adapt to Tian Jin area is recommended and CAD program is developed.

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박난영. "Ba Jin and Christianity: Focusing on Tian Huishi". Journal of the research of chinese novels ll, n.º 46 (agosto de 2015): 305–26. http://dx.doi.org/10.17004/jrcn.2015..46.013.

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Saejung, Satit y Kanokwan Wongchan. "Strong Convergence for a Strongly Quasi-Nonexpansive Sequence in Hilbert Spaces". Abstract and Applied Analysis 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/174302.

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We prove a strong convergence theorem for strongly quasi-nonexpansive sequence of mappings in Hilbert spaces. Moreover, we can improve the recent results of Tian and Jin (2011). We also give a simple proof of Marino-Xu’s result (2006).

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Zhang, Fengjiao, Xiaochun Shu, Ning Wang y Zhong Wang. "Jin Ling Tian Cheng: A New Ornamental Lycoris chinensis Cultivar". HortScience 59, n.º 8 (agosto de 2024): 1106–7. http://dx.doi.org/10.21273/hortsci17913-24.

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Song, Hanzhi. "“Ren” and Spatial Design in Ancient Chinese Architecture: A Discussion from the Perspective of Confucian Aesthetic Concepts". Advances in Social Science and Culture 6, n.º 1 (14 de diciembre de 2023): p29. http://dx.doi.org/10.22158/assc.v6n1p29.

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This paper adopts the unique perspective of Confucian aesthetic principles to investigate their profound impact on the interrelationship between “Ren” (benevolence) and spatial design in classical Chinese architecture. Drawing upon core Confucian concepts such as “Ren”, “Tian Ren He Yi” (the unity of man and nature), and “Jin Shan Jin Mei” (the pursuit of perfection), the study meticulously analyzes specific instances of classical architectural layouts and spatial designs, providing a detailed exposition of the manifestation of “Ren”. Subsequently, it elucidates how Confucian aesthetic principles influence classical architecture by inheriting and developing the spirit of benevolence and adeptly applying an aesthetic consciousness of the unity of space and time. Simultaneously, the paper distinctly presents the profound insights of Confucian aesthetic principles on contemporary spatial design and societal development. This influence extends beyond the formal and structural aspects of architecture, permeating deeply into the cultural connotations embedded in architecture. It injects distinctive and valuable design wisdom into contemporary society, contributing not only to the comprehension of the cultural value of ancient architecture but also furnishing a novel framework for contemporary spatial design. In doing so, it offers concrete and far-reaching guidance for the construction of a harmonious society.

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Wang, Shan, Chuanwu Cao y Jian-Hao Chen. "In Situ Tuning of Magnetism in Fe3GeTe2 via Argon Ions Irradiation". Magnetochemistry 9, n.º 5 (9 de mayo de 2023): 125. http://dx.doi.org/10.3390/magnetochemistry9050125.

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We report the continuous argon ions irradiation of itinerant Fe3GeTe2, a two-dimensional ferromagnetic metal, with the modification to its transport properties measured in situ. Our results show that defects generated by argon ions irradiation can significantly weaken the magnetization (M) and coercive field (Hc) of Fe3GeTe2, demonstrating the tunable magnetism of this material. Specifically, at base temperature, we observed a reduction of M and Hc by up to 40% and 62.4%, respectively. After separating the contribution from different mechanisms based on the Tian-Ye-Jin (TYJ) scaling relation, it’s the skew scattering that dominates the contribution to anomalous Hall effect in argon ions irradiated Fe3GeTe2. These findings highlight the potential of in situ transport modification as an effective method for tailoring the magnetic properties of two-dimensional magnetic materials, and provides new insights into the mechanisms underlying the tunable magnetism in Fe3GeTe2.

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Liu, Chao y Natalya Mikhailovna Kuzmishcheva. "Deconstruction of V. Mayakovsky’s satirical play “The Bedbug” in a romantic-utopian and a postmodern version in Chinese reception". Philology. Issues of Theory and Practice 17, n.º 2 (2 de febrero de 2024): 291–99. http://dx.doi.org/10.30853/phil20240041.

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The study aims to identify the influence of V. Mayakovsky’s satire on Chinese drama. The paper examines the works of Chinese authors created under the influence of V. Mayakovsky’s satirical play “The Bedbug”. In Tian Han’s play “The Ballad of the Ming Tombs Reservoir” and in Jin Shan’s eponymous film, the idea of moving into the future determines the plot and the compositional structure. Meng Jinghui’s drama “The Bedbug” (the 2000, 2013 and 2017 productions) repeats the main plot of V. Mayakovsky’s play and retains many lines from the original work. This is the first staging of Mayakovsky’s play in China. The scientific novelty of the study lies in the fact that Mayakovsky’s influence on Chinese drama is for the first time being considered from the cultural and historical perspective and reflects the dynamics of perception of Mayakovsky’s satire in China starting with a romantic-utopian view, associated with the concept of the “Great Leap Forward” (Tian Han), to a postmodern view (Meng Jinghui). The study of the Chinese-language material on the reception of Mayakovsky’s satire, which remains unexplored in Russia, will make it possible to expand the understanding of the attitude to the creative work of the Russian futurist poet and playwright abroad not only among literary scholars, but also the reading public. The study found that the satirical comedy by the Russian poet of the turn of the 19th-20th centuries in the deconstructed versions reflects the problems of the formation of Chinese society in the 20th-21st centuries.

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Zhang, Bo-Lang, Kai-Sheng Chen, Xing Hu y Kun Zhang. "A Variable-Order Dynamic Constitutive Model for Clay Based on the Fractional Calculus". Applied Sciences 12, n.º 13 (24 de junio de 2022): 6416. http://dx.doi.org/10.3390/app12136416.

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To accurately describe the deformation characteristics of clay under long-term cyclic load, based on fractional calculus theory, elastoplastic theory and the basic element model, a variable-order fractional dynamic model designed to predict accumulative strain of clay was exhibited. Firstly, the cyclic load was separated into static and alternating load in accordance with cyclic load characteristics, and the strain of clay under static and alternating load was analyzed. Then, on the basis of the variable-order Abel dashpot model, rheological theory and elastoplastic theory, the expressions of the rheological constitutive model and strain response were both obtained. Finally, in combination with the undrained dynamic triaxial testing of Zhan Jiang clay and Tian Jin soft clay, a series of analyses was carried out on the effectiveness and parameter sensitivity of the model when subjected to long-term cyclic loading. By comparing the dynamic constitutive model with pre-existing models, the superiority of the dynamic constitutive model is revealed. The results show that the dynamic constitutive model can characterize properly the deformation characteristics of clay under the action of long-term cyclic loading, especially in its accelerating stage. The parameter sensitivity of the model exhibits a growing trend with the increment of loading duration.

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Wei, Zhang. "The Discussion on the Content of the Teaching and Learning Evaluation Standard in the Physical Education-Take the Example of Taijiquan Teaching in Tian Jin University Renai College". IOP Conference Series: Materials Science and Engineering 452 (13 de diciembre de 2018): 042043. http://dx.doi.org/10.1088/1757-899x/452/4/042043.

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Xigui, Qiu. "The Early China Forum An Examination of Whether the Charges in Shang Oracle-Bone Inscriptions are Questions*". Early China 14 (1989): 77–114. http://dx.doi.org/10.1017/s0362502800002601.

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Oracle-bone scholars have long uniformly read the charges (i.e., the portion that mentions the event being divined) of Shang oracle-bone inscriptions as questions. Since the 1970's, many foreign oracle-bone scholars have proposed a new view that the charges are never questions, or at least are generally not questions. Whether or not the charges are actually questions is a very important question bearing not only on oracle bone studies, but also on research on ancient divination and on ancient Chinese grammar. Based on an examination of a great number of Shang oracle-bone inscriptions, the author of this essay believes that charges that can now be determined to be questions are mainly those choice-type charges in early inscriptions that contain the final particles yi and zhi, and true-or-false type charges that contain yi. Charges of the type “V bu V” (such as “rain not rain” [yu bu yu]) and “V bu,” regarded by many as choice-type questions, are actually comprised of the charge and a verification or use notation, the “bu V” being a verification and the “bu” being either a verification or a use notation (similar to the notation bu yong, “do not use”). Charges that can now be determined not to be questions are mainly in those inscriptions with complex charges, such as “this *spring the king ought not ally with Wang Cheng to attack Xia Wei, (for if he does) he will not receive divine assistance” (jin ?chun wang wu bi Wang Cheng fa Xia? Wei, fu qi shou you you, and “On ren we ought not hunt, (for if we do) it will rain” (ren wu tian, qi yu), the syntax of which shows that they cannot be questions.

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Tian, Yang, Feng Jiang, Athina Jaffer, Benjamin Hopkins, Jian Jin y Hideo Watanabe. "Abstract 1693: Drug-tolerant persister cells contain heterogeneous subpopulations that utilize lung lineage pathways as drug resistance mechanism". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 1693. http://dx.doi.org/10.1158/1538-7445.am2023-1693.

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Abstract Genomic discoveries of oncogenic driver alterations in lung cancer have led to development of effective target therapeutics; however, patients who initially respond to the therapy inevitably experience regrowth of the disease. Recent studies identified a reversible stage of cancer cells entering a quiescent state to ensure survival, called drug-tolerant persister (DTP) cells. The DTP stage is viewed as a major source of non-genetic drug resistance, while its epigenetic dynamic and regulatory mechanisms remain largely unknown. To determine the epigenetic activity reminiscent of a quiescent state during DTP development, we evaluated repressive epigenetic modifications during DTP progression and found that DTP cells had a markedly increased H3K27me3 level at the beginning of DTP stage. Treatment of EZH2 inhibitor together with target therapy synergistically inhibited cell growth, indicating the essential role of compressed chromatin structure for DTP survival. To further investigate the epigenomic heterogeneity of DTP cells, we performed single cell ATAC-seq on DTP cells. Unsupervised hierarchical clustering analysis revealed that the drug-induced DTP cells had two distinct populations compared with the untreated group with only one major population, suggesting an increased epigenomic heterogeneity. By analyzing the differentially accessible regions, motifs for TEADs and GATAs were specifically enriched in DTP cells, whose family members are well-established regulators of the lung development. This raised a possibility that the evolution of drug resistance shares similarities with organ regeneration, both require terminally differentiated cells regaining cell plasticity and serving as a progenitor cell to direct re-differentiation. Thus, we focused on alveolar lineage genes as a model to test our hypothesis that DTP cells hijack conserved developmental pathways for lung regeneration to ensure their survival and subsequent expansion. Our results showed that specific alveolar marker genes were transiently upregulated and exhibited translocation from cytoplasm to nuclei at early phase of DTP. Moreover, deletion of the alveolar lineage gene decreased cell re-growth under drug treatment. Our finding provides a new perspective of anti-relapse therapeutic strategies, that targeting lung lineage pathways to manipulate the activity of critical lineage factors during lung regeneration, for patients with minimal residual disease and relapse after target therapy. Citation Format: Yang Tian, Feng Jiang, Athina Jaffer, Benjamin Hopkins, Jian Jin, Hideo Watanabe. Drug-tolerant persister cells contain heterogeneous subpopulations that utilize lung lineage pathways as drug resistance mechanism [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1693.

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Fang, Li-Zhi. "Jiang Xiaoyuan ;, Wu Yan . Zijin shan tian wen tai shi gao: Zhongguo tian wen xue xian dai hua ge an. [History of Purplemountain Observatory.] (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 219 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2004. 29 (paper)." Isis 99, n.º 3 (septiembre de 2008): 645–46. http://dx.doi.org/10.1086/593267.

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Lin, Yuehe y Dan (Annie) Du. "(Invited) New Bioinspired Nanomaterials for Biosensing and Cancer Theranostics". ECS Meeting Abstracts MA2022-01, n.º 53 (7 de julio de 2022): 2202. http://dx.doi.org/10.1149/ma2022-01532202mtgabs.

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Nature is an excellent source of inspiration for the widespread application of science and technology. Researchers learn from biological principles and gradually develop from the earliest direct use of biological materials to the design and development of new biomimetic materials inspired by nature. Therefore, the innovation of bioinspired nanomaterials will enable tremendous advances in biology and biochemistry with biomimetic capabilities, such as biosensing, cell imaging, and drug delivery. In this presentation, I will discuss my group’s recent work on two bioinspired nanomaterials: nano-peptoids and single-atom nanozymes. The first type of bioinspired materials is a sequence-defined peptide-like materials that can mimic the structure and function of peptides and proteins. Compared with peptides and proteins, peptoids have a high degree of thermal and chemical stability, and are resistant to proteolytic degradation. In addition, due to the lack of intramolecular and intermolecular backbone hydrogen bond donors, it is possible to precisely control the peptoid and peptoid-substrate interactions, leading to bio-inspired synthesis of nanomaterials with a layered structure. As a peptide mimic, the peptoids has biocompatibility, non-toxicity and sequence-specific heteropolymers. Nano-peptoids can be synthesized with polar and hydrophobic monomers and have the following advantages: They can be easily processed into desired shapes (e.g. dendritic, sheets, tubes and vesicles), and the size range is 2-100 nm to enhance cell targeting and uptake. The application of nano-peptoids in cell imaging and cancer theranostics will be discussed. Another type of bioinspired nanomaterials with enzyme-like properties is single-atom nanoenzymes. As a biocatalyst, natural enzymes have the ability to accelerate various reaction rates with extremely high activity and selectivity under mild conditions. However, due to the temperature and pH-related denaturation of proteins and the possibility of contamination by bacteria or other reagents, the shelf life of natural enzymes is limited or uncertain, and their purification and production costs are high. Therefore, natural enzymes must narrow the range of conditions under which they can be used, limiting their further applications in biosensing and biomedicine. R Recent research has focused on the rational design of nanomaterials with inherent enzyme-like catalytic properties (for example, oxidase, peroxidase, catalase, superoxide dismutase, and so on) and exploration of their applications in various fields. Although much progress has been made, the development of nanozymes is still hampered by several challenges. Catalytic activity and substrate selectivity are the two most important issues that need to be resolved to allow the technology to reach full maturity. Therefore, rational design and tuning of nanomaterials is highly desirable for the development of novel enzyme-mimic nanomaterials with precise catalytic sites. We have developed various Fe-N-C based single atomic site catalysts which have similar structure with active site of peroxidase. These atomically-dispersed Fe-N-C materials have enzyme-like properties, therefore they are classified as single-atom nanozymes. Together with their abundantly exposed active sites and specific structures, these single atomic nanozymes have great potential for the enhancement of biocatalytic activity and selectivity in biosensing. Jiao, H. Yan, Y. Wu, W. Gu, C. Zhu, D. Du, Y. Lin. When Nanozymes Meet Single-Atom Catalysis. Angew. Chem. Int. Ed. 2020,132, 2585-2596 Zhu, S. Fu, Q. Shi, D. Du, Y. Lin. Single-Atom Electrocatalysts. Angew. Chem. Int. Ed. 2017, 56, 13944-13960. Cheng, J. Li, D. Liu, Y. Lin, D. Du. Single-Atom Nanozyme Based on Nanoengineered Fe-N-C Catalyst with Superior Peroxidase-Like Activity for Ultrasensitive Bioassays. Small, 2019, 1901485. Niu, Q. Shi, W. Zhu, D. Liu, H. Tian, S. Fu, N. Cheng, S. Li, J. N Smith, D. Du, Y. Lin. Unprecedented Peroxidase-mimicking Activity of Single-atom Nanozyme with Atomically Dispersed Fe-Nx Moieties Hosted by MOF Derived Porous Carbon. Biosensors & Bioelectronics, 2019, 142, 111495. Jiao, W. Xu, Y. Wu, H. Yan, W. Gu, D. Du, Y Lin, C. Zhu, Single-atom Catalysts Boost Signal Amplification for Biosensing. Chemical Society Reviews 2021, 50, 750-765 Luo, Y. Song, M. Wang, T. Jian, S. Ding, P. Mu, Z. Liao, Q. Shi, X. Cai, H. Jin, D. Du, W. Dong, C. Chen, Y. Lin. Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy. Small 2019, 1902485. Song, M. Wang, S. Akkineni, W. Yang, J.J. Hettige, H. Jin, Z. Liao, P. Mu, F. Yan, M. Baer, J. De Yoreo, D. Du, Y. Lin, C. Chen. Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids. ACS Materials Letters 2021, 3, 420-427. Cai, M. Wang, P. Mu, T. Jian, D. Liu, S. Ding, Y. Luo, D. Du, Y. Song, C. Chen, Y. Lin. Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma. Research 2021, Article ID 9861384.

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Jin, Lin, Jing Yang, Zhujun Yi, Hong S. Kim, Feng Tian y Jiaqi Shi. "Abstract PO-125: The role of KDM6A in pancreatic cancer immune microenvironment". Cancer Research 81, n.º 22_Supplement (15 de noviembre de 2021): PO—125—PO—125. http://dx.doi.org/10.1158/1538-7445.panca21-po-125.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States, with a 10% 5-year survival rate. Immunosuppressive myeloid cells, including tumor-associated neutrophils (TANs), contribute to tumor development and treatment resistance. Lysine (K)-specific demethylase 6A (KDM6A) is one of the most frequently mutated epigenetic genes and a tumor suppressor in PDAC. However, the molecular mechanisms by which KDM6A contributes to PDAC development and whether KDM6A impacts the tumor immune microenvironment are unknown. This study established a genetically engineered pancreas-specific Kdm6a-knockout Ptf1aCre;LSL-KrasG12D/+;LSL-p53R172H/+ (KPC) PDAC mouse model to investigate the influence of KDM6A loss on PDAC development and tumor immune microenvironment. We found that KDM6A loss accelerated PDAC progression and increased metastases. Pancreata of mice with Kdm6a deficiency developed aggressive undifferentiated PDACs. Additionally, KDM6A loss led to increased infiltration of TANs and neutrophil extracellular traps (NETs) formation. Mechanistically, we used Bru-seq technology to investigate the impact of KDM6A on nascent RNA transcription. We demonstrated that many chemotactic cytokines related to neutrophil recruitment, specifically CXCL1, were upregulated in KDM6A-knockout PDAC cells. We further confirmed increased CXCL1 mRNA and protein levels in KDM6A-deficient human and mouse PDAC cells. In addition, immunohistochemical staining also confirmed the upregulated CXCL1 expression in both human and murine PDAC cells with KDM6A loss. TANs were found to express CXCR2, the receptor of CXCL1, by immunofluorescent analysis. To further confirm that cancer cells with KDM6A loss can attract neutrophils in vitro, we performed chemotaxis assays using both human neutrophils derived from PLB-985 cells and mouse primary neutrophils isolated from bone marrow and conditioned media from KDM6A- knockout or knockdown PDAC cells. We found that PDAC cells with KDM6A loss promoted neutrophil recruitment in vitro compared to KDM6A-retained PDAC cells. Furthermore, the CXCL1 neutralizing antibody reversed the chemotactic property of KDM6A-deficient PDAC cells, confirming that CXCL1 is the primary chemokine mediating the neutrophil recruitment. In summary, these findings shed light on the mechanism by which KDM6A loss promotes PDAC development, regulates tumor immune microenvironment, and suggests that the CXCL1-CXCR2 axis may be a candidate target for the treatment of PDAC, especially those with KDM6A mutations. Citation Format: Lin Jin, Jing Yang, Zhujun Yi, Hong S. Kim, Feng Tian, Jiaqi Shi. The role of KDM6A in pancreatic cancer immune microenvironment [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-125.

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Skidmore, Lillian, Jingjing Zhu, David Mills, Ting Jin, Suqin Li, Keith Tatsukawa, Nick A. Knudsen et al. "Abstract 6318: Preclinical characterization of ARX305, a next-generation anti-CD70 antibody drug conjugate for the treatment of CD70-expressing cancers". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 6318. http://dx.doi.org/10.1158/1538-7445.am2023-6318.

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Abstract CD70 has emerged as an attractive tumor target with its over-expression in multiple solid and hematological cancers, yet tightly controlled and limited expression in normal cells. In the last decade, multiple anti-CD70 antibody drug conjugates (ADCs) have been developed, but most, if not all, of these ADC programs have been discontinued. Using an expanded genetic code to create Engineered Precision Biologics (EPBs), Ambrx has developed ARX305, a CD70-targeted next-generation antibody drug conjugate (ADC) to potentially overcome the challenges associated with earlier ADCs and treat patients with cancers over-expressing CD70. ARX305 is comprised of a proprietary, high-affinity, humanized anti-CD70 antibody stably and site-specifically conjugated to AS269, a potent microtubule inhibitor. After binding to CD70 expressed on target tumor cells, ARX305 internalizes and releases the cytotoxic payload pAF-AS269 which inhibits cellular proliferation. In vitro testing across a panel of solid and liquid tumor cell lines showed ARX305 elicited highly potent and specific cell killing across multiple tumor types with medium to high CD70 expression levels. In multiple in vivo CD70-expressing xenograft or disseminated models, ARX305 induced significant tumor growth inhibition or regression whereas unconjugated antibody exhibited poor activity. ARX305 utilizes stable oxime conjugation chemistry, a non-cleavable PEG linker, and a membrane-impermeable payload to minimize premature payload release in circulation and associated off-target toxicity. These properties of ARX305 result in high serum stability, with rodent pharmacokinetic studies confirming a similar exposure profile of ARX305 compared to unconjugated antibody and a long serum half-life. Repeat dose toxicokinetic studies in cynomolgus monkeys demonstrated ARX305 was tolerated at exposures well above therapeutic exposures in mouse pharmacology studies, indicating a wide therapeutic index. In summary, the highly potent anti-tumor activity in multiple tumor types and wide therapeutic index of ARX305 support clinical evaluation of this next generation anti-CD70 ADC. ARX305 is currently in a Phase 1 dose escalation study in China, and the IND in the United States is open. Citation Format: Lillian Skidmore, Jingjing Zhu, David Mills, Ting Jin, Suqin Li, Keith Tatsukawa, Nick A. Knudsen, Liying Gong, Jay Nelson, Kari Cox, Amha G. Hewet, Jianing Wang, Tim Buss, Feng Tian, Gang Xia, Shawn Zhang. Preclinical characterization of ARX305, a next-generation anti-CD70 antibody drug conjugate for the treatment of CD70-expressing cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6318.

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Lucas, François y Evelyne Emery. "Letter to the Chief Editor: Outcome of thoracolumbar burst fractures treated with indirect reduction and fixation without fusion. Huilin Yang, Jin-hui Shi, Molly Ebraheim, Xiaochen Liu, Joseph Konrad, Ibrahim Husain, Tian-si Tang, Jiayong Liu Eur Spine J. Published online 8 August 2010". European Spine Journal 20, n.º 7 (18 de enero de 2011): 1192. http://dx.doi.org/10.1007/s00586-010-1684-3.

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Wang, Hui, Pongsiri Kamkankaew, Phithagorn Thanitbenjasith, Vachiraporn Phattarowas y Surakit Khumwongpin. "The Perception of Customer-based Brand Equity in China's tea industry: A case study Tian Shang Ren Jian Brand". International Journal of Sociologies and Anthropologies Science Reviews 3, n.º 4 (15 de julio de 2023): 157–68. http://dx.doi.org/10.60027/ijsasr.2023.2979.

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Background and Aim: A brand equity might be its monetary value, its position in a company's balance sheet, or customers' loyalty and confidence in the goods offered by the business. This study aims to explore the level of perception of customer-based brand equity of the Tian Shang Ren Jian brand in China's tea industry and to study the guideline for Customer based Brand Equity development of the Tian Shang Ren Jian brand in China's tea industry Materials and Methods: This research is a quantitative research method. The total sample size for the research will be 385 customers of the Tian Shang Ren Jian brand. The questionnaire was used as a tool to collect data. Statistical values such as percentage, frequency, mean, and standard deviation were used for data analysis. Results: The results suggest that each of the variables demonstrated elevated values, with an average score of 4.11 and a deviation from the mean of 0.64. The levels of brand awareness, image, perceived quality, and loyalty were significantly higher. Tian Shang Ren Jian's customer-based brand equity ideas can help China's tea sector build successful partnerships by emphasizing individualization and self-conceptual links. Tian Shang Ren Jian needs to improve its understanding of the brand, sales promotion, and digital media technologies to uphold consumer confidence and enhance brand/product communication. Conclusion: Tian Shang Ren Jian's customer-based brand equity ideas can help China's tea sector build successful partnerships, with an average score of high level from the mean. Managers and marketers of Tian Shang Ren Jian brand should review their situation analysis and rethink their brand identity to improve sustainability.

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Zhang, Jin, Qiang Liu, Hongchuan Jiang, Jianguo Zhang, Jianghua Ou, Dedian Chen, Fuguo Tian, Yongqing Li, Xiaoming Cheng y Zhong Ouyang. "Abstract OT1-12-06: Neoadjuvant pyrotinib versus pertuzumab in combination with trastuzumab and nab-Paclitaxel for patients with HER2-positive early or locally advanced breast cancer (Pyramid): A randomized, multicenter, open-label, phase 2 trial". Cancer Research 82, n.º 4_Supplement (15 de febrero de 2022): OT1–12–06—OT1–12–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-ot1-12-06.

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Abstract Background: Pyrotinib is an irreversible pan-ErbB receptor tyrosine kinase inhibitor targeting human epidermal growth factor receptor 1 (HER1), HER2, and HER4. Exploratory studies of neoadjuvant pyrotinib combined with trastuzumab-based standard chemotherapy for HER2-positive (HER2+) early or locally advanced breast cancer (BC) showed promising pathological complete response (pCR) rates of 51.6%-71%, with a manageable toxicity profile. We are to further investigate this combination strategy versus standard therapy in a randomized trial. Trial design: Pyramid is a randomized, multicenter, open-label, two-stage adaptive enrichment phase 2 trial to evaluate the efficacy and safety of pyrotinib plus trastuzumab and nab-Paclitaxel versus pertuzumab plus trastuzumab and nab-Paclitaxel as neoadjuvant treatment in patients with HER2+ early or locally advanced BC (NCT04900311). Eligible patients will be randomized 1:1 to receive four 21-day cycles of pyrotinib (400 mg, po, qd) or pertuzumab (840 mg loading dose, 420 mg maintenance doses, i.v., day 1) with trastuzumab (8 mg/kg loading dose, 6 mg/kg maintenance doses, i.v., day 1) and nab-Paclitaxel (260 mg/m2, day 1 or 125 mg/m2, i.v., day 1/8/15). After completion of neoadjuvant treatment, patients will undergo surgery, followed by standard EC regime for 4 cycles. Subsequent adjuvant therapy will be decided by investigators. Randomization was stratified by hormone receptor (HR) status (ER and/or PR positive vs. negative) and primary tumor size (2<T≤5 cm vs. T>5 cm). There will be two stage of this trial, and population may be enriched to HR-positive based on the results of interim analysis at Stage I. Eligibility criteria: Key inclusion criteria include female, treatment-naïve, histologically confirmed HER2+ invasive BC (cT2-4/cN0-3/cM0), the diameter of primary tumor > 2 cm, known HR status (ER and PR). Specific aims: Primary endpoint is total pathologic complete response (tpCR) rate per central review assessment. Secondary endpoints include invasive disease-free survival, event-free survival, objective response rate, breast-conserving surgery rate, safety. Exploratory endpoint is to investigate the possible predictive biomarkers of efficacy. Statistical methods: A sample size of 220 patients per arm is calculated to provide a power of 80% with a significance level of 0.1 (one-sided) to detect an estimated increase in the tpCR rate from 39% in the pertuzumab group to 49% in the pyrotinib group. Considering a dropout rate of 10%, 490 patients (245 per arm) will be required to be enrolled. A two-stage adaptive enrichment design will be used. The trial will enroll 186 patients at Stage I and an interim analysis will be conducted by an independent data monitoring committee (IDMC) when the pathologic response has been evaluated in at least 132 patients (including at least 66 HR-positive patients) at Stage I. Then, one of five options might be adapted at Stage II depending on the results, including: i. Continue study as planned in whole population; ii. Re-estimate sample size in whole population; iii. Enrich to HR-positive population with pre-defined sample size; iv. Enrich to HR-positive population and re-estimate sample size; v. Early termination. The Clopper-Pearson method will be used to calculate a 95% confidence interval (CI) for the tpCR rate. The CMH chi-square test will be used to compare the tpCR rate between groups and 95% CIs for the difference will be estimated using the Miettinen-Nurminen method. Present accrual and target accrual: Target enrollment will be 490 patients at approximately 20 sites in China. As of June 24, 2021, 4 patients have been enrolled. Contact information: Jin Zhang, MD, Email: zhangjin@tjmuch.com. Citation Format: Jin Zhang, Qiang Liu, Hongchuan Jiang, Jianguo Zhang, Jianghua Ou, Dedian Chen, Fuguo Tian, Yongqing Li, Xiaoming Cheng, Zhong Ouyang. Neoadjuvant pyrotinib versus pertuzumab in combination with trastuzumab and nab-Paclitaxel for patients with HER2-positive early or locally advanced breast cancer (Pyramid): A randomized, multicenter, open-label, phase 2 trial [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT1-12-06.

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Liu, Jiayong y Joseph Konrad. "Answer to the Letter to the Editor of F. Lucas et al. concerning “Outcome of thoracolumbar burst fractures treated with indirect reduction and fixation without fusion” by Huilin Yang, Jin-Hui Shi, Molly Ebraheim, Xiaochen Liu, Joseph Konrad, Ibrahim Husain, Tian-Si Tang, Jiayong Liu. Eur Spine J. Published online 8 August 2010". European Spine Journal 20, n.º 7 (20 de enero de 2011): 1193. http://dx.doi.org/10.1007/s00586-011-1687-8.

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Subanakov, Alexey K., Evgeniy V. Kovtunets, Sampil Zh Choydonov, Sesegma G. Dorzhieva y Bair G. Bazarov. "Синтез и характеризация нового двойного бората рубидия–гольмия Rb3HoB6O12". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, n.º 2 (14 de junio de 2019): 278–86. http://dx.doi.org/10.17308/kcmf.2019.21/765.

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Методом цитратной золь-гель технологии получен новый двойной борат рубидия–гольмия состава Rb3HoB6O12. Соединение кристаллизуется в тригональной сингонии (пр. гр. R32, a = 13.4038(7), с = 30.315(2) Å, V = 4716.76 Å3) и плавится инконгруэнтно при 818 °С. Попытки получить в однофазном состоянии Rb3HoB6O12 методом твердофазных реакций не привели к положительному результату REFERENCES Wu C., Yang G., Humphrey M.G., Zhang C. Recent advances in ultraviolet and deep-ultraviolet secondorder nonlinear optical crystals // Chem. Rev., 2018, v. 375, pp. 1–30. https://doi.org/10.1016/j.ccr.2018.02.017 Bubnova R., Volkov S., Albert B., Filatov S. Borates – crystal structures of prospective nonlinear optical materials: high anisotropy of the thermal expansion caused by anharmonic atomic vibrations // Crystals, 2017, v. 7, pp.1–32. DOI: 10.3390/cryst7030093 Becker P. Borate materials in nonlinear optics // Mater., 1998, v. 10, pp. 979–992. https://doi.org/10.1002/(SICI)1521-4095(199809)10:13<979::AIDADMA979>3.0.CO;2-N Chen C., Li R. The anionic group theory of the nonlinear optical effect and its applications in the development of new high-quality NLO crystals in the borate series // Rev. Phys. Chem., 1988, v. 8, pp. 65–91. https://doi.org/10.1080/01442358909353223 Chen C., Wu Y., Jiang A., Wu B., You G., Li R., Lin S. New nonlinear-optical crystal: LiB3O5 // Opt. Soc. Am. B: Opt. Phys., 1989, v. 6, pp. 616–621. https://doi.org/10.1364/JOSAB.6.000616 French R. H., Ling J. W., Ohuchi F. S., Chen C. T. Electronic structure of b-BaB2O4 and LiB3O5 nonlinear optical crystals // Rev. B: Condens. Matter, 1991, v. 44, pp. 8496–8502. https://doi.org/10.1103/Phys-RevB.44.8496 Yusuke Mori, Ikio Kuroda, Satoshi Nakajima, Takamoto Sasaki, Sadao Nakai. New nonlinear optical crystal: Cesium lithium borate // Phys. Lett., 1995, v. 67, pp. 1818–1820. https://doi.org/10.1063/1.115413 Haohai Yu, Zhongben Pan, Huaijin Zhang, Jiyang Wang. Recent advances in self-frequency-doubling crystals // Materiomics, 2016, v. 2, pp. 55–65. https://doi.org/10.1016/j.jmat.2015.12.001 Bajor A.L., Kisielewski J., Klos A., Kopzyński K., Lukasiewicz T., Mierczyk J., Mlyńczak J. Assessment of gadolinium calcium oxoborate (GdCOB) for laser applications // Opto-electronics Review, 2011, v. 19, pp. 439–448. https://doi.org/10.2478/s11772-011-0042-2 Dan Zhao, Cong-Kui Nie, Ye Tian, Bao-Zhong Liu, Yun-Chang Fan, Ji Zhao. A new luminescent host material K3GdB6O12: synthesis, crystal structure and luminescent properties activated by Sm3+ // Kristallogr., 2018, v. 233, pp. 411–419. https://doi.org/10.1515/zkri-2017-2101 Dan Zhao, Fa-Xue Ma, Rui-Juan Zhang, Wei Wei, Juan Yang, Ying-Jie Li. A new rare-earth borate K3LuB6O12: crystal and electronic structure, and luminescent properties activated by Eu3+ // Mater Sci: Mater Electron., 2017, pp. 1–9. https://doi.org/10.1007/s10854-016-5501-6 Atuchin V. V., Subanakov A. K., Aleksandrovsky A. S., Bazarov B. G., Bazarova J. G., Dorzhieva S. G., Gavrilova T. A., Krylov A. S., Molokeev M. S., Oreshonkov A. S., Pugachev A. M., Tushinova Yu. L., Yelisseyev A. P. Exploration of structural, thermal, vibrational and spectroscopic properties of new noncentrosymmetric double borate Rb3NdB6O12 // Powder Technol., 2017, v. 28, pp. 1309–1315. https://doi.org/10.1016/j.apt.2017.02.019 Atuchin V. V., Subanakov A. K., Aleksandrovsky A. S., Bazarov B. G., Bazarova J. G., Gavrilova T. A., Krylov A. S., Molokeev M. S., Oreshonkov A. S., Stefanovich S. Yu. Structural and spectroscopic properties of new noncentrosymmetric selfactivated borate Rb3EuB6O12 with B5O10 units // Des., 2018, v. 140, pp. 488–494. https://doi.org/10.1016/j.matdes.2017.12.004 Sangen Zhao, Guochun Zhang, Jiyong Yao, Yicheng Wu. K3YB6O12: A new nonlinear optical crystal with a short UV cutoff edge // Res. Bull., 2012, v. 47, pp. 3810–3813. https://doi.org/10.1016/j.materresbull.2012.05.062 Miriding Mutailipu, Zhiqing Xie, Xin Su, Min Zhang, Ying Wang, Zhihua Yang, Muhammad Ramzan Saeed Ashraf Janjua, Shilie Pan. Chemical cosubstitution- oriented design of rare-earth borates as potential ultraviolet nonlinear optical materials // Am. Chem. Soc., 2017, v. 139, pp. 18397–18405. https://doi.org/10.1021/jacs.7b11263 Li Yang, Yingpeng Wan, Honggen Weng, Yanlin Huang, Cuili Chen, Hyo Jin Seo. Luminescence and color center distributions in K3YB6O12 : Ce3+ phosphor // Phys. D: Appl. Phys., 2016, v. 49 (325303), pp. 1–12. https://doi.org/10.1088/0022-3727/49/32/325303

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STOOP, Patricia. "Dboec vanden tien ghebodenvan Jan van Leeuwen". Ons Geestelijk Erf 75, n.º 2 (1 de septiembre de 2001): 182–235. http://dx.doi.org/10.2143/oge.75.2.565511.

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Sangtam, Noklangkumla, Sunanda Haorongbam, Kshetrimayum Silpa y Yumnam Priyabarta Singh. "Bronchiectasis in patients with chronic obstructive pulmonary disease in a tertiary care center in North-East India". International Journal of Advances in Medicine 7, n.º 4 (21 de marzo de 2020): 656. http://dx.doi.org/10.18203/2349-3933.ijam20201118.

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Background: Bronchiectasis is common in patients with Chronic Obstructive Pulmonary Disease (COPD). COPD with bronchiectasis has been considered a phenotype with worse lung function and more severe exacerbations. There is scarce literature on the characteristics and optimal management of such patients.Methods:Patients with COPD reporting within the one-year study period were subjected to High Resolution Computed Tomography (HRCT) scan of the thorax. Sputum was sent for Gram-stain and culture/sensitivity for patients found to have bronchiectasis. Bronchiectasis Severity Index (BSI) was calculated using the online BSI calculator. Association between presence of bronchiectasis and gender, lung function and frequency of exacerbations was statistically analysed.Results: Total 62 patients with COPD were enrolled. Bronchiectasis was present in 11 (17.7%) patients. The most common bacterial isolate from sputum of patients with bronchiectasis was Haemophilus influenza (54.54%). The prevalence of bronchiectasis was more in females (19.45% compared to 15.4% in males), but this association was not found to be statistically significant(p=0.748). Forced Expiratory volume in 1st second (FEV1) was found to be significantly lower in patients with bronchiectasis (p<0.05). There was increased frequency of exacerbations among patients with bronchiectasis. This association was however not found to be statistically significant (p=0.765), 1 (9.1%) patient had low BSI score (0-4), 3 (27.3%) patients had intermediate BSI score (5-8) and 7 (63.3%) patients had high BSI score (≥9).Conclusions:The presence of bronchiectasis in COPD is a phenotype associated with a poor clinical course. The characteristics of this co-existence are largely unknown. More studies are required to properly characterize and manage patients with this coexistence. 1. Global Initiative for Chronic Obstructive Lung Disease Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. 2014. Available at: http://wwwgoldcopdorg/. Accessed 1 February, 20182. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease 2019 report. Available at: https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf. Accessed 24 January 2019.3. Martínez-García MA, de la Rosa Carrillo D, Soler-Cataluña JJ, Donat-Sanz Y, Serra PC, Lerma MA, et al. Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. Am J Respirat Crit Care Med. 2013 Apr 15;187(8):823-31.4. Pasteur MC, Bilton D, Hill AT. British Thoracic Society guideline for non-CFbronchiectasis. Thorax. 2010 Jul 1;65(Suppl 1):i1-58.5. Mao B, Lu HW, Li MH, Fan LC, Yang JW, Miao XY, et al. The existence of bronchiectasis predicts worse prognosis in patients with COPD. Scientific reports. 2015 Jun 16;5:10961.6. Jin J, Yu W, Li S, Lu L, Liu X, Sun Y. Factors associated with bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease. Med (Baltimore) 2016;95(29):e4219.7. Du Q, Jin J, Liu X, Sun Y. Bronchiectasis as a co morbidity of chronic obstructive pulmonary disease: a systematic review and meta-analysis. PLoS One. 2016;11(3):e0150532.8. Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H. Clinical characteristics of patients with chronic obstructive pulmonary disease with co morbid bronchiectasis: a systemic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2015;10:1465-75.9. Loebinger MR, Wells AU, Hansell DM, Chinyanganya N, Devaraj A, Meister M, et al. Mortality in bronchiectasis: a long-term study assessing the factors inﬂuencing survival. Eur Respir J. 2009;34(4):843-9.10. Rakhimova E, Wiehlmann L, Brauer AL, Sethi S, Murphy TF, Tummler B. Pseudomonas aeruginosa population biology in chronic obstructive pulmonary disease. J Infect Dis. 2009;200(12):1928-35.11. Chalmers JD, Goeminne P, Aliberti S, McDonnell MJ, Lonni S, Davidson J, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med. 2014;189(5):576-85.12. Dou S, Zheng C, Cui L, Xie M, Wang W, Tian H, et al. High prevalence of bronchiectasis in emphysema-predominant COPD patients. Int J Chron Obstruct Pulmon Dis. 2018;13:2041-7.13. Ramakrishna R, Ambica A. Association of Bronchiectasis in Moderate to Severe COPD patients attending Katuri Medical College Hospital, Guntur from 2011-2013. J Evidence Based Med Healthcare 2015;2(13):2062-76.14. Martinez-Garcia MA, Soler-Cataluna JJ, Donat Sanz Y, Catalan Sera P, Agramunt Lerma M, Ballestin Vicente J, et al. Factors associated with bronchiectasis in patients with COPD. Chest 2011;140(5):1130-7.15. Kumar S, Singh GV, Gupta RK, Singh H, Prakash G. To estimate the prevalence of bronchiectasis in COPD patients. IOSR JDMS. 2018;17(3):82-90.16. Woodhead M, Blasi F, Ewig S. Guidelines for the management of adult lower respiratory tract infections. Eur Respir J. 2005;26:1138-80.17. Patel IS, Vlahos I, Wilkinson TM, Lloyd-Owen SJ, Donaldson GC, Walks M, et al. Bronchiectasis, Exacerbation indices and Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2004;170(4):400-7.18. Chen YH, Sun YC. Bronchiectasis as a co morbidity of chronic obstructive pulmonary disease: implications and future research. Chin Med J (Engl). 2016;129(17):2017-9.19. Gatheral T, Kumar N, Sansom B. COPD-related bronchiectasis; independent impact on disease course and outcomes. COPD. 2014;11(6):605-14.20. Goeminne PC, Nawrot TS, Ruttens D, Seys S, Dupont LJ. Mortality in non-cystic fibrosis bronchiectasis: a prospective cohort analysis. Respir Med. 2014 Feb 1;108(2):287-96.21. Hurst JR, Elborn JS, De Soyza A. COPD–bronchiectasis overlap syndrome. Eur Respir J. 2015;45:310-3.

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Sholah, Hanif Maulaniam, Ilmi Nikmatul Hikmah y Mufarrohah. "TIPOLOGI SANTRI MASJID TIBAN SANANREJO". INTAJ : Jurnal Penelitian Ilmiah 2, n.º 02 (5 de octubre de 2018): 1–32. http://dx.doi.org/10.35897/intaj.v2i02.133.

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Interesting Phenomenon in an Islamic place called “Pondok Pesantren” which is located in Sananrejo village Turen district region of Malang attracts many attentions to a large of citizens. It is issued that the Pondok Pesantren which is well known with the term Pondok Pesantren Bihār Bahr ‘Asal Fadlāil al-Rahmah is a Mosque which is built by spirit where many people called them as “Jin”. In this case, this research is eager to investigate the motivation which become the background of establishing the Pondok Pesantren, how the proses of constructing this huge building with eleven floors and more than one hectare area of building; how the belief and characters which is taught in this Pondok Pesantren; and how the typology as well as ideology of Santri in this Pondok Pesantren. This research applies descriptive qualitative method by which the data collection is carried out using observation and interview. This also brings out phenomenology approach to reveal the ideology of the santris of Bihār Bahr ‘Asal Fadlāil al-Rahmah. Based on the result of observation and interview conducted and analyzed by the researcher, Santris of this Salafī Pesantren which is often visited by many visitors, and even foreigners from any regions, show polite attitude. This behaviour has become the tradition and culturally implemented by all of Santris in this pesantren toward any visitors. Keywords: Typology, Santri, Pondok Pesantren

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Harvey, B., L. Jin, J. Maull, C. Hu, Y. Tian y Z. Kaymakcalan. "FRI0367 ADALIMUMAB IS MORE EFFECTIVE THAN ETANERCEPT AT PREVENTING TNF-ENHANCED OSTEOCLAST DEVELOPMENT THROUGH DOWNREGULATION OF PRO-OSTEOCLASTOGENIC FACTORS ICAM-1 AND IGFBP2 AND UPREGULATION OF ANTI-OSTEOCLASTOGENIC FACTOR FABP4". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 781.1–781. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2036.

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Background:TNF has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF and RANKL. We have previously demonstrated that TNF enhances the kinetics of RANKL-induced human osteoclastogenesis and that its effects are mitigated more effectively by the anti-TNF biologic adalimumab (ADA) as compared to etanercept (ETN).Objectives:To determine the mechanism responsible for the difference in effectiveness between the two biologics, a label-free quantitative proteomics study was conducted on TNF-activated human osteoclasts (OC) upon biologic treatment.Methods:Human bone marrow-derived OC precursors (OCP, 3 donors) were exposed for 5 days to M-CSF, M-CSF+RANKL (RANKL) alone or in combination with 100 ng/mL TNF +/- 5 ug/mL ADA, ETN or human IgG1 (IGG) as pre-formed complexes. OC differentiation was confirmed by measuring TRAP5b activity. Shotgun proteomics was performed on peptides generated from detergent based cell extracts subjected to methanol/chloroform precipitation and trypsin/Lys-C digestion. Data acquisition was performed with Orbitrap Q Exactive™ HF-X mass spectrometer. MaxQuant was utilized to quantify proteins based on MS1 peak intensities. Data matrix was normalized, imputed and subjected to differential expression analysis by limma. DAVID pathway analysis (DPA) was used to identify pathways impacted by various treatment conditions based on proteins exhibiting significant (p<0.05) 1.2-fold change in expression as compared to RANKL. Protein levels within culture supernatant or cell lysate were verified by ELISA or MSD.Results:Principle component analysis (PCA) of the proteomic profiling data for the 3 donors indicated that exposure of OCP to TNF induced a distinct profile from that of M-CSF and RANKL. The addition of ADA:TNF complexes restored the profile to that of RANKL, whereas those exposed to ETN:TNF complexes exhibited an intermediate profile matching differences observed in TRAP 5b activity levels. DPA identified 3 pathways most associated with osteoclastogenesis: receptor-mediated endocytosis (e.g. CD163, IGFBP2), oxidation-reduction process (e.g. FABP4), and cell adhesion (e.g. ICAM-1, TGFBI) that were significantly impacted by TNF with ADA:TNF being more effective than ETN:TNF in restoring most pathway-associated proteins to RANKL levels. Based on ELISA, two pro-osteoclastogenic factors IGFBP2 and ICAM-1 were increased 2-fold in OCP culture supernatants in response to TNF with only ADA:TNF complexes reducing these levels of both to RANKL. TNF-induced reduction of intracellular levels of CD163, an M2 macrophage polarization marker, and TGFBI were not only restored to RANKL levels by ADA:TNF but brought to a level closer to M-CSF alone, unlike ETN:TNF. One anti-osteoclastogenic factor FABP4 was found to be increased intracellularly above that of RANKL only following exposure to ADA:TNF complexes.Conclusion:Shotgun proteomic profiling of human OCP differentiatedin vitrowith TNF revealed at least 3 novel pathways by which TNF exerts its pro-osteoclastogenic effects. Only with the addition of ADA:TNF, not with ETN:TNF, were most pathway-associated proteins significantly restored to RANKL levels including pro-osteoclastogenic factors ICAM-1 and IGFBP2. Moreover, ADA:TNF complexes enhanced the intracellular levels of CD163 and the anti-osteoclastogenic factor FABP4, suggesting these complexes are exerting an effect on OCP beyond simple TNF neutralization. Additionalin vitroandin vivostudies need to be performed to verify our findings.Acknowledgments:The authors thank Drs. Jochen Salfeld, Yonghao Cao and Dhaval Nanavati for their critical review of our data, and Yucheng Zhang for her technical support.Disclosure of Interests:Bohdan Harvey Shareholder of: AbbVie, Inc., Employee of: AbbVie, Inc., Liang Jin Shareholder of: AbbVie, Inc., Employee of: AbbVie, Inc., John Maull Shareholder of: AbbVie, Inc., Employee of: AbbVie, Inc., Chenqi Hu Shareholder of: AbbVie, Inc., Employee of: AbbVie, Inc., Yu Tian Shareholder of: AbbVie, Inc., Employee of: AbbVie, Inc., Zehra Kaymakcalan Shareholder of: AbbVie, Inc., Employee of: AbbVie, Inc.

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Jin, Jung-Il. "Preface". Pure and Applied Chemistry 83, n.º 12 (1 de enero de 2011): iv. http://dx.doi.org/10.1351/pac20118312iv.

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<div>IUPAC’s vision statement declares that the Union advances the worldwide role of chemistry for the benefit of Mankind. And one of its long-range goals states “IUPAC will utilize its global perspective and network to contribute to the enhancement of chemistry education, the career development of young chemical scientists, and the public appreciation of chemistry”. In pursuit of this spirit, the Union established in 2000 the IUPAC Prize for Young Chemists and has been honoring since then outstanding young research chemists at the beginning of their careers by making annual awards. The prizes are given for the most outstanding Ph.D. theses in the area of the chemical sciences, as described in 1000-word essays. For details, please refer to <http://www.iupac.org/news/prize.html> (IUPAC Prizes for Young Chemists). IUPAC awards up to five prizes annually, each comprising USD 1000 and travel expenses to the next IUPAC Congress. As immediate Past President of IUPAC, I was honored to chair the prize selection committee of eminent chemists, who enjoyed reading essays of 47 applicants from 19 countries. The committee was extremely pleased to note the increase in the number of applicants to 47 from 29 last year. This increase is in excellent accord with IUPAC’s worldwide celebration of the International Year of Chemistry throughout this year. After critical evaluation of the originality and excellence of the essays and research results, the committee decided unanimously to award 2011 Prizes to the following six chemists: Rubén D. Costa, University of Valencia, Valencia, Spain: “Theoretical and experimental study of light-emitting electrochemical cells based on ionic transition-metal complexes: From the molecule to the device” William Donald, University of California, Berkeley, CA, USA: “Ion nanocalorimetry: Measuring absolute reduction potentials and investigating effects of water on electron solvation and ion fluorescence” Matthew Macauley, Simon Fraser University, Burnaby, BC, Canada: “Insight into O-GlcNAc protein modification using chemical and biochemical tools” Bozhi Tian, Harvard University, Cambridge, MA, USA: “Design, synthesis, and characterization of novel nanowire structures for photovoltaics and intracellular probes” Sheng Xu, Georgia Institute of Technology, Atlanta, GA, USA: “Oxide nanowire arrays for energy sciences” Chengqi Yi, University of Chicago, Chicago, IL, USA: “Probing the AlkB family DNA/RNA repair enzymes with a chemical disulphide cross-linking approach” All the awardees were invited to present posters on their research at the 43rd IUPAC World Chemistry Congress, San Juan, Puerto Rico, 30 July-6 August 2011. Upon IUPAC’s invitation, five of the six winners offered review papers on their research topics for consideration as publications in Pure and Applied Chemistry (PAC). And the five refereed articles appear in this issue of PAC. Finally, it is an honor and a pleasure to congratulate each of the winners and their supervisors for winning the 2011 IUPAC Prize for Young Chemists. It is hoped that each of them will continue to contribute to a bright future for chemical sciences and technologies and to take active roles in IUPAC bodies in the future. Jung-Il Jin IUPAC Immediate Past President and Chair of the IUPAC Prize Selection Committee </div>

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Zheng, Chao, Dandan Ma, Linfeng Zhao, Maolin Guo, Shude Cui, Fuguo Tian, Zhimin Fan et al. "Abstract P4-03-31: Lifestyle factors are associated with breast cancer risk in women biopsied for benign breast diseases in China: 10-year results of a multi-center, hospital-based, case-control study". Cancer Research 83, n.º 5_Supplement (1 de marzo de 2023): P4–03–31—P4–03–31. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-03-31.

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Abstract Objective: Benign breast disease (BBD), especially benign proliferative breast disease (BPBD), is related to increased breast cancer risk. However, few studies have examined whether conventional breast cancer risk factors influence risk of breast cancer among women with BBD. The aim of this study was to evaluate the associations of lifestyle factors with risk of breast cancer among women biopsied for BBD within a multi-center, hospital-based, case-control study in China, in order to provide scientific basis of health guidance for BBD patients and lay the foundation for primary prevention of breast cancer. Methods: A multi-center, hospital-based, case-control study was conducted. Patients with BPBD (n=608) and patients with non-proliferative breast disease (NPBD) (n=366) were collected from 23 hospitals in 11 provinces during April 2012 to April 2013. A face-to-face survey, baseline data and fasting blood was collected with all study subjects. Serum adiponectin levels were assayed using ELISA. After 10 years, the cumulative incidence rate of breast cancer in the two groups was counted through follow-up. Logistic regression analysis was used to obtain the association between specific factors and risk of breast cancer. Results: After 10 years’ follow-up, 388 BPBD and 240 NPBD cases were included in the final analysis (Table 1), of which 16 (4.12%) and 3 (1.25%) developed breast cancer, respectively. The cumulative incidence of breast cancer between the two groups was significant difference (P=0.041). Compared with women in the NPBD group, BPBD group were more likely to be central obesity (with higher waist-to-hip ratio (WHR)) (OR 24.98, 95% CI 1.845-336.203, P=0.015) and less likely to have physical activity (OR 0.626, 95% CI 0.416-0.943, P=0.025) and less often to eat carrots (OR 0.616, 95% CI 0.398-0.953, P=0.030) (Table 2). Subgroup analyze indicated that, physical activity, eat carrots and ham sausage, body weight, BMI, waist circumference and WHR were statistical differences in premenopausal BPBD patients, while only physical activity (OR 0.423, 95% CI 0.269-0.665 P < 0.001) was the independent risk factors. Meanwhile, among the factors of Tea consumption, Glycemia, Body weight, BMI, Waist circumference, WHR and HMW/total adiponectin ratio in postmenopausal group, only HMW/total adiponectin ratio (OR 0.041, 95% CI 0.002-0.820 P=0.037) was statistically significant factor. These stratified multivariate logistic regression analysis results are shown in Table 3. Conclusion: In patients with BBD, physical activity may be the protect factor for breast cancer carcinogenesis in premenopausal women while lower HMW/total adiponectin ratio is a risk factor for postmenopausal women, which can provide direction for primary prevention of breast cancer. Table 1. Pathological types of all subjects. Table 2. The results of multivariate Logistic regression analysis. Table 3. Stratified multivariate Logistic regression analysis by menopause status. Citation Format: Chao Zheng, Dandan Ma, Linfeng Zhao, Maolin Guo, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shi-Guang Zhu, Wenshu Zuo, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Mingming Guo, Yongjiu Wang, Wenzhong Zhou, Shuya Huang, Zhaohui Li, Yajie Zhou, Lijuan Hou, Xinyi Yang, Xuan Zhang, Liyuan Liu, Zhigang Yu. Lifestyle factors are associated with breast cancer risk in women biopsied for benign breast diseases in China: 10-year results of a multi-center, hospital-based, case-control study [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-03-31.

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이상철. "The Theories of Play-making in Lü tian cheng and Qi biao jia". 아시아문화연구 17, n.º ll (noviembre de 2009): 307–33. http://dx.doi.org/10.34252/acsri.2009.17..013.

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VOVES, J., O. MĚRKA, K. ČABANOVÁ, J. JANOŠEK y G. BAJOR. "Type IV Titanium Hypersensitivity: Rare, or Rarely Detected?" Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 90, n.º 2 (1 de abril de 2023): 85–91. http://dx.doi.org/10.55095/achot2023/012.

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Nguyen, Quang-Khoi, Thi-Phuong-Loan Nguyen, Van-Tuan Huynh, Nguyet-Thuan Phan y Huynh-Tuan-Anh Nguyen. "efficient decay model for studying the luminous flux behavior of phosphor-converted white light-emitting diodes". Photonics Letters of Poland 15, n.º 4 (31 de diciembre de 2023): 72–74. http://dx.doi.org/10.4302/plp.v15i4.1250.

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We proposed a new idea for testing the thermal decay of light source under the effect of heat where the lux meter is used rather than using the integrating sphere and the thermal camera is used rather than thermocouple. The thermal decay behavior of the light is detected by using the lux meter. The thermal camera can be used to provide the temperature value as well as the temperature distribution of the measured surface which is more convenient than by using the thermocouple. This fitting model is useful for finding out the decay rate of output light under thermal effect. Full Text: PDF References E.F. Schubert and J. K. Kim, "Solid-State Light Sources Getting Smart", Science 308, 1274-1278 (2005). CrossRef E.F. Schubert, Light-emitting diodes (Cambridge University Press, 2006). CrossRef N. Narendran and Y. Gu, "Life of LED-based white light sources", J. Disp. Technol. 1, 167-171 (2005). CrossRef Y.Y. Chang, Z.Y. Ting, C.Y. Chen, T.H. Yang, and C.C. Sun, "Design of Optical Module With High Stability, High Angular Color Uniformity, and Adjustable Light Distribution for Standard Lamps", J. Disp. Technol. 10, 223-227 (2014). CrossRef C.C. Sun, C.Y. Chen, C.C. Chen, C.Y. Chiu, Y.N. Peng, Y.H. Wang, T.H. Yang, T.Y. Chung, and C.Y. Chung, "High uniformity in angular correlated-color-temperature distribution of white LEDs from 2800K to 6500K", Opt. Express 20, 6622-6630 (2012). CrossRef C.C. Sun, Q.K. Nguyen, T.X. Lee, S.K. Lin, C.S. Wu, T.H. Yang, and Y.W. Yu. "Active thermal-fuse for stopping blue light leakage of white light-emitting diodes driven by constant current", Sci. Rep. 12, 12433 (2022). CrossRef Q.K. Nguyen, Y.J. Lin, C. Sun, X.H. Lee, S.K. Lin, C.S. Wu, T.H. Yang, T.L. Wu, T.X. Lee, C.H. Chien, Y.W. Yu & C.C. "GaN-based mini-LED matrix applied to multi-functional forward lighting", Sun. Sci. Rep. 12, 6444 (2022). CrossRef T.T. N. Le, C.T. Liao, S.K. Lin, C.S. Wu, Q.K. Nguyen, T.H. Yang, Y.W. Yu, and C.C. Sun. "Study of banana preservation extension by UVC radiation in precise monitoring LED irradiation cavity", Sci. Rep. 12, 21352 (2022). CrossRef N. Narendran, Y. Gu. "Life of LED-based white light sources", J. Disp. Technol. 1, 167 (2005). CrossRef G.H. Xiao, W.J. Du, Z.Y. Wang, G.L. Chen, L.H. Zhu , Y.L. Gao , Z. Chen , Z.Q. Guo, Y.J. Lu. "Two-Dimensional Transient Temperature Distribution Measurement of GaN Light-Emitting Diode Using High Speed Camera", IEEE J. Electron Devices Soc. 9, 663-666 (2021). CrossRef N. Han, T.V. Cuong, M. Han, B.D. Ryu, S. Chandramohan, J.B. Park, J.H. Kang, Y.J. Park, K.B. Ko, H.Y. Kim, H.K. Kim, J.H. Ryu, Y.S. Katharria, C.J. Choi, C.H. Hong. "Improved heat dissipation in gallium nitride light-emitting diodes with embedded graphene oxide pattern", Nat Commun 4, 1452 (2013) CrossRef M. Cai, D.G. Yang, K.M. Tian, P. Zhang, X.P. Chen, L.L. Liu, G.Q. Zhang. "Step-stress accelerated testing of high-power LED lamps based on subsystem isolation method", Microelectron Reliab 55, 1784 (2015). CrossRef K.S. Chang, S.C. Yang, J.Y. Kim, M.H. Kook, S.Y. Ryu, H.Y. Choi, G.H. Kim. "Precise Temperature Mapping of GaN-Based LEDs by Quantitative Infrared Micro-Thermography", Sensors 12, 4648-4660 (2012). CrossRef Y. Gao, J. Jin, Y.J. Ruan, Y.L. Gao, L.H. Zhu, Z.Q. Guo, Y. Lin, Z. Chen, and Y.J. Lu. "Two-dimensional temperature distribution measurement of light-emitting diodes by micro-hyperspectral imaging-based reflected light method", Optics Express 27, 7945 (2019). CrossRef B.L. Liang , Z.L. Wang , C. Qian , Y. Ren , B. Sun , D.Z. Yang , Z. Jing and J.J. Fan. "Investigation of Step-Stress Accelerated Degradation Test Strategy for Ultraviolet Light Emitting Diodes", Materials 12, 3119 (2019). CrossRef J. Hegedüs, G. Hantos, A. Poppe. "Lifetime Modelling Issues of Power Light Emitting Diodes", Energies 13, 3370 (2020). CrossRef A. Alexeev, J.P. Linnartz, G. Onushkin, K. Arulandu, G. Martin. "Dynamic response-based LEDs health and temperature monitoring", Measurement 156, 107599 (2020). CrossRef K. Paisnik, G. Rang and T. Rang. "Life-time characterization of LEDs", Est J. Eng 17, 241 (2011). CrossRef A. Vaskuri, P. Kärhä, H. Baumgartner, O. Kantamaa, T. Pulli, T. Poikonen, E. Ikonen. "Relationships between junction temperature, electroluminescence spectrum and ageing of light-emitting diodes", Metrologia 55, S86 (2018). CrossRef

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Messner, Steven F., Lening Zhang, Sheldon X. Zhang y Colin P. Gruner. "Neighborhood Crime Control in a Changing China". Journal of Research in Crime and Delinquency 54, n.º 4 (1 de junio de 2017): 544–77. http://dx.doi.org/10.1177/0022427816682059.

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Objectives: This research assesses the impacts of three distinctive crime control activities organized and directed by the neighborhood committees with the assistance of local police in contemporary urban China—Tiao-jie, Bang-jiao, and neighborhood watches. Tiao-jie deals with disputes and minor criminal cases. Bang-jiao provides guidance to residents who have committed minor offenses or have been released from correctional institutions to facilitate reintegration. Neighborhood watches engage local residents in crime prevention under the direction of neighborhood committees. Method: Using survey data recently collected in Tianjin, we examine the effects of indicators of the implementation of these neighborhood-based crime control strategies on residents’ reports of household property victimizations that occurred within the neighborhoods with multilevel logistic regressions. Results: Net of a range of individual-level and neighborhood-level control variables, the indicators of the level of activity of Tiao-jie, Bang-jiao, and neighborhood watches exhibit negative effects on reported household property victimization. Conclusions: Our findings provide suggestive evidence that the traditional strategies of neighborhood-level crime control continue to be relevant in the China of today and that the role of collective efficacy appears to differ from that observed in Western cities.

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Dai, Hai-Ting, Tie-Jun Bing, Zhi-Da An, Jie Yang, Tian-Yu Pang, Jia-Wei Gao, Yun-Yi Bo y Wen-Jen Yu. "Abstract 2819: Novel drug resistant CDX models for anti-cancer drugs discovery". Cancer Research 84, n.º 6_Supplement (22 de marzo de 2024): 2819. http://dx.doi.org/10.1158/1538-7445.am2024-2819.

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Abstract Oncogene BRAF is located on chromosome 7q34, consisting of 766 amino acids and 22 exons, encoding a serine/threonine protein kinase belonging to the RAF family and plays a critical role in the MAPK signaling pathway. The mutation of BRAF was documented in nearly 8% of all human cancers including melanoma (60%), thyroid (60%), and lung adenocarcinoma (10%). The most common mutation of BRAF is V600E (Class I), which was found in more than 70% in these cancers. Despite the clinical success of approved small molecule inhibitors of BRAF V600E (vemurafenib, dabrafenib and encorafenib), this remains an area of unmet medical need because of primary or acquired drug resistance. The construction of BRAF drug-resistant cell lines plays a pivotal role in cancer research. It serves as a crucial tool for discovery of the mechanisms of drug resistance. In this study, we have developed a systematic approach for constructing drug-resistant cell lines, inducing resistance through the gradual escalation of drug concentrations. The validation of drug resistance involves morphological recordings of parent and drug-resistant cell lines, drug resistance index in vitro through IC50 measurements and in vivo through the inhibition of tumor growth (TGI) which compare to those in the parental cell line. We successfully established Vemurafenib and Dabrafenib resistant A375 cell lines (A375 Vemurafenib R, A375 Dabrafenib R) with 21 and 31.5 folds of resistance index, respectively. The in vivo drug resistance efficacy was also tested by implanting Vemurafenib resistant cells subcutaneously into NOD-SCID mice and showed that A375 Vemurafenib R exhibited robust tolerance to 50 mg/kg Vemurafenib treatment (P.O.21 days, 50mpk, TGI=17.4%), whereas the parental cells were nearly completely inhibited (P.O.21 days, 50mpk, TGI=92.3%). In addition, single-cell sequencing of A375 Vemurafenib R revealed significant gene expression differences in the MAPK and EGFR signaling pathways, aiding in the identification of new targets, and signaling pathways associated with drug resistance, thereby providing potential targets for new drug development. Citation Format: Hai-Ting Dai, Tie-Jun Bing, Zhi-Da An, Jie Yang, Tian-Yu Pang, Jia-Wei Gao, Yun-Yi Bo, Wen-Jen Yu. Novel drug resistant CDX models for anti-cancer drugs discovery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2819.

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Laksananny, Satya Agustina, Erny Poedjirahajoe, Ris Hadi Purwanto y Muh Taufik Tri Hermawan. "Analisis Vegetasi Hutan Mangrove di Kabupaten Buton Utara (Studi Kasus di Kecamatan Kulisusu Barat, Kabupaten Buton Utara, Sulawesi Tenggara)". Jurnal Ilmu Lingkungan 18, n.º 3 (1 de diciembre de 2020): 515–21. http://dx.doi.org/10.14710/jil.18.3.515-521.

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Kabupaten Buton Utara merupakan salah satu daerah yang potensial hutan mangrovenya baik dari segi hasil hutan kayunya (HHK) maupun hasil hutan bukan kayu (HHBK) dan sangat dipengaruhi oleh kondisi ekologisnya, yang meliputi substrat, suhu, pH dan salinitas air. Lokasi penelitian ini di Desa Dampala Jaya dan Bumi Lapero, Kecamatan Kulisusu Barat, Kabupaten Buton Utara. Penelitian ini bertujuan untuk mengetahui :1) untuk mengetahui jenis vegetasi mangrove di lokasi pnelitian; 2) untuk mengetahui struktur vegetasi penyusun hutan mangrove di lokasi penelitian;3) untuk mengetahui Indeks Nilai Penting mangrove di lokasi penelitian; 4) untuk mengetahui Indeks keanekaragaman mangrove. Metode penelitian yang digunakan adalah menggunakan kombinasi desain jalur dan metode garis berpetak (Onrizal, 2008). Hasil penelitian ini menunjukkan bahwa di lokasi penelitian terdapat 5 (lima) jenis vegetasi mangrove, yaitu Bruguiera gymnorrhyza, Rhizophora stylosa, Xylocarpus granatum, Heriteria littoralis, Bruguiera parviflora. Indeks Nilai Penting di Desa Dampala Jaya yang tertinggi adalah spesies Bruguiera gymnorrhyza baik pada tingat semai (100,05), tiang atau pancang (93,93) dan pohon (95,75); sedangkan Indeks Nilai Penting terendah di tingkat semai Heriteria littoralis (12,71), tingkat tiang atau pancang dan tingkat pohon adalah spesies Bruguiera parviflora,masing-masing dengan nilai 17,71 dan 17,93. Indeks Nilai Penting tertinggi di Desa Bumi Lapero tingkat semai yaitu adalah Bruguiera gymnorrhyza yaitu 82,28, tingkat pancang atau tiang Rhizophora stylosa yaitu 114,07, tingkat pohon Bruguiera gymnorrhyza yaitu 106,04. Indeks Nilai Penting terendah adalah spesies Bruguiera parviflora baik pada tingkat semai (8.00), tingkat tiang atau pancang (12,66) dan tingkat pohon (22,78). Indeks keanekaragaman (H’) di Desa Dampala Jaya tertinggi pada tingkat semai yaitu spesies Bruguiera parviflora (0,21), sedangkan tingkat tiang atau pancang terdapat pada spesies Bruguiera gymnorrhyza dan Rhizophora stylosa masing-masing 0,37 begitu juga pada tingkat pohon terdapat pada spesies Bruguiera gymnorrhyza dan Rhizophora stylosa dengan nilai masing-masing 0,37. Indeks Nilai Penting vegetasi mangrove menggambarkan pentingnya peranan satu jenis spesies mangrove dalam ekosistem hutan mangrove. Jika Indeks Nilai Penting vegetasi mangrove tinggi nilainya, maka spesies mangrove itu sangat mempengaruhi kestabilan ekosistem hutan mangrove. Nilai Indeks Keanekaragaman di Desa Dampala yang tertinggi adalah Rhizophora stylosa pada tingkat semai yaitu 0,36, tingkat pancang atau tiang Bruguiera gymnorrhyza dan Rhizophora stylosa yaitu 0,37, tingkat pohon Bruguiera gymnorrhyza dan Rhizophora stylosa yaitu 0,37. Nilai indeks keanekaragaman di Desa Bumi Lapero yang tertinggi pada tingkat semai adalah Rhizophora stylosa yaitu 0,36, pada tingkat pancang atau tiang Bruguiera gymnorrhyza yaitu 0,37, pada tingkat pohon Rhizophora stylosa yaitu 0,37. Berdasarkan kriteria keanekaragaman Barbour et al. (1987) dalam Syamsuddin, N., (2019); H’= 1-2 (rendah), H’=2-3 (sedang), H’= 3-4 (tinggi), H’= >4 (sangat tinggi), sehingga Nilai Indeks Keanekaragaman di Desa Dampala Jaya dan Desa Bumi Lapero tergolong rendah.

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Yang, Sheng-Min, Yin-Yu Chang, Dong-Yih Lin, Da-Yung Wang y Weite Wu. "Thermal Stability of TiAlN and Nanocomposite TiAlSiN Thin Films". Journal of Nanoscience and Nanotechnology 9, n.º 2 (1 de febrero de 2009): 1108–12. http://dx.doi.org/10.1166/jnn.2009.c098.

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Kang, Byeong-Mo, Woon-Jo Jeong, Gye-Choon Park, Dong-Joo Yoon, Ho-Geun Ahn y Yeong-Seog Lim. "The Characteristics of an Antibacterial TiAgN Thin Film Coated by Physical Vapor Deposition Technique". Journal of Nanoscience and Nanotechnology 15, n.º 8 (1 de agosto de 2015): 6020–23. http://dx.doi.org/10.1166/jnn.2015.10417.

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Purbajanti, Endang, Kusmiyati F y Eny Fushkah. "Water use efficiency and nutrient uptake of rice under soil water stress condition". Jurnal Pertanian Tropik 7, n.º 1 (6 de abril de 2020): 72–81. http://dx.doi.org/10.32734/jpt.v7i1.3732.

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One obstacle that can limit the growth and production of rice is low water availability. Therefore, a comprehensive study of the response of rice plants to drought is very important. The study was conducted in the greenhouse of the Faculty of Animal Husbandry and Agriculture, Diponegoro University, from April to August 2016. The study used a 3 x 3 factorial design with 3 replications. The first factor is three types of rice (Sidenuk, Way Apo Buru, Pepe) and the second factor is water stress treatment (KA <field capacity = enough water, field capacity (KL), water saturation (JA). The observed parameters are protein content, leaf levels rolling (number of leaves rolled), relative water content (RWC), water use efficiency (WUE), N, P, K uptake, rice protein content decreases with increasing water supply. The relative water content of rice plants decreases with increasing stress water that occurs in the limited water supply for the three types of rice Sidenuk rice has the lowest N seed content (2.1%) compared to Way Apo (3.0%) and Pepe (3.1%). The mineral content of P in both biomass and seeds is not really influenced by water stress, as well as K content of seeds. REFERENCES Badan Pusat Statistik. 2018. https://www.bps.go.id/dynamictable/2019/04/15/1608/luas-panen-produksi-dan-produktivitas-padi-menurut-provinsi-2018.html Darwesh, R, S,S. 2013. Improving growth of date palm plantlets grown undersalt stress with yeast and amino acids applications Annals of Agricultural Science (2013) 58(2), 247–256 Etienne P.I.D, S. Diquelou , M. Prudent, C. Salon., A. Maillard, and A.Ourry. 2018. Macro and Micronutrient Storage in Plants and Their Remobilization When Facing Scarcity: The Case of Drought. Agriculture 2018, 8, 14; 2-17. doi:10.3390/agriculture8010014 Farooq, M., S.M.A.Basra, A. Wahid, Z.A.Cheema, M.A.Cheema, A.Khaliq. 2008. The physiological role of exogenously applied glycine betaine in improving drought tolerance of fine grain aromatic rice (Oryza sativa L.).Journal of Agronomy & Crop Science, 194: 325-333. Fitter, A.H.dan R.K.M. Hay. 1991. Fisiologi lingkungan tanaman. Gadjah Mada University Press, Yogyakarta Gholinezhad, E., A.Ayanaband, A. H. Ghorthapeh, G.Noormohamadi, I.Bernousi.2009. Study of the Effect of Drought Stress on Yield, Yield Components, and Harvest Index of Sunflower Hybrid Iroflor at Different Levels of Nitrogen and Plant Population. Not. Bot. Hort. Agrobot. Cluj 37 (2) 2009, 85-94 Kivuva, B.M. , S.M. Githiri, G. C. Yencho, J.Sibiya.2015. Screening sweet potato genotypes for tolerance to drought stress. Field Crops Research 171 (2015) 11–22 Jaleel CA, Manivannan P, Wahid A, Farooq M, Al-Juburi H J, Somasundaram R, Panneerselvam R. 2009. Drought stress in plants: A review of morphological characteristics and pigment composition. Int J Agric Biol, 11: 100–105. Nazar, R., S. Umar, N.A. Khan, O. Sareer. 2015. Salicylic acid supplementation improves photosynthesis and growth in mustard through changes in proline accumulation and ethylene formation under drought stress. South African Journal of Botany 98 (2015) 84–94. Nio, S.A. dan A.A. Lenak. 2014. Penggulungan daun pada tanaman monokotil saat kekurangan air. Journal Bio Logos, Agustus 2014, Vol.2, No 4: 48-55. Nuryani, S.H.U., Haji,M., Widya, N. Y., 2010. Serapan hara N,P,K pada tanaman padi dengan lama penggunaan pupuk organic pada vertisol Sragen. Jurnal Ilmu Tanah dan Lingkungan vul 10 No 1 : 1-13 Oh, M.W., and S. Komatsu. 2015. Characterization of proteins in soybean roots under flooding and drought stresses. Journal of Proteomics. 114 (2015): 161-181. Pandey, V., and A.Shukla.2015.Acclimation and Tolerance Strategies of Rice under Drought Stress. Rice Science, 2015, 22(4): 147-.161. Penny-packer, B. W., K. T. Leath., W. L. Stout, and R. R. Hill. 1990. Technique for stimulating field drought stress in the greenhouse. Agr. J. 82 (5): 951–957. Purbajanti, E.D., F. Kusmiyati, and E. Fuskhah. 2017. Growth, Yield, and Physiological Characters of Three Types of Indonesian Rice Under Limited Water Supply. Asian J. Plant Sci., 16 (2): 101-108, 2017. Shi, G., S. Xia., J. Ye, Y. Huang, C. Liu, Z. Zhang .2015. PEG-simulated drought stress decreases cadmium accumulation in castor bean by altering root morphology. Environmental and Experimental Botany 111 (2015) 127–134. Shao H B, L.Y.Chu, M.A. Shao, C.A.Jaleel, H.M. Mi. 2008. Higher plant antioxidants and redox signaling under environmental stresses. Comp Rend Biol, 331: 433–441. Steel, R.G.D., and J.H. Torrie, 1960. Principles and Procedures of Statistics. McGraw-Hill, New York, USA. Suryanti, S., D. Indradewa, P. Sudira, J. Widada. 2015. Water Use, Water Use Efﬁciency, and Drought Tolerance of Soybean Cultivars. AGRITECH, Vol. 35, No. 1, February 2015: 114-120. Wu,X. and W. Bao. 2011. Leaf Growth, Gas Exchange and Chlorophyll FluorescenceParameters in Response to Different Water Deficits in Wheat Cultivars. Plant Prod. Sci. 14(3): 254―259 (2011) Zhang, X., X. Chen, Z. Wu, X. Zhang, C. Huang and M. Cao, 2005. A dwarf wheat mutant is associated with increased drought resistance and altered responses to gravity. Afr. J. Biotechnol., 4: 1054-1057. Zou L., X.Sun, Z. Zhan, P. Li, J. Wu, Tian Cai-juan, Qiu Jin-long, Lu Tie-gang (2011) Leaf rolling controlled by the homeodomain leucine zipper class IV gene Roc5 in rice. Plant Physiology 156:1589– 1602

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Kwon, Sang-Woo. "The Suspicion of Confucianism and the Explanation of Islam: Focuced on Jim Tian-zhu(��)’s Qing-Zhen-Shi-Yi(��)". Journal of Social Thoughts and Culture 23, n.º 01 (30 de marzo de 2020): 89–122. http://dx.doi.org/10.17207/jstc.2020.03.23.1.3.

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Kwon, Ji-Seon, Chang-Hwan Park, Jae-Woong Choi, Chang-Hyun Lee, Sun-Young Sohn y Hwa-Min Kim. "Preparation and Characterization of the Sputtered TiAlN Coatings Using a Ti–Al Alloy Metal Target". Journal of Nanoscience and Nanotechnology 19, n.º 10 (1 de octubre de 2019): 6493–98. http://dx.doi.org/10.1166/jnn.2019.17059.

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Sutopo, Teguh y Vi Khoiriyatin Nisa. "Sistem Pakar Diagnosa Penyakit pada Tanaman Pisang Mas Kirana dengan Pendekatan Fuzzy Logic Tsukamoto". Jurnal Insan Unggul 11, n.º 1 (1 de marzo de 2023): 59–82. http://dx.doi.org/10.47926/jiu.2023.11.1.59-82.

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Kelembapan, jamur, dan kumbang merupakan faktor yang dapat menghambat keberhasilan produksi tanaman pisang mas Kirana. Guna mempermudah petani dan pemilik perkebunan yang ingin memulai pembudidayaan tanaman pisang mas Kirana, dibutuhkan suatu sistem yang dapat bertugas membantu mendiagnosa penyakit yang terdapat pada tanaman pisang mas Kirana tersebut, serta memberikan solusi agar dapat menghindari berbagai penyakit yang dapat menghambat pertumbuhan serta produksi dari tanaman pisang mas Kirana. Basis pengetahuan yang digunakan dalam sistem pakar ini yaitu pendekatan algoritma fuzzy logic Tsukamoto. Metode ini dapat bekerja dengan baik karena menggunakan aplikasi nilai monoton. Masukannya berupa gejala-gejala yang dialami kemudian akan diproses dengan kaidah (IF–THEN). Keluaran hasil dari tiap-tiap aturan diberikan secara tegas. Sistem pakar dirancang untuk berinteraksi langsung dengan pemakai dengan format dialog tanya jawab. Metode pengembangan sistem menggunakan waterfall dan pemodelan sistem menggunakan UML. Sedangkan alur penelitian digambarkan dengan diagram alir dan bahasa pemrograman menggunakan PHP.

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Aziz, Aziz, Henri Henri y Wahyu Adi. "Ragam Vegetasi Hutan Rawa Air Tawar di Taman Wisata Alam Jering Menduyung, Bangka Barat". Jurnal Ilmu Lingkungan 18, n.º 1 (29 de abril de 2020): 200–208. http://dx.doi.org/10.14710/jil.18.1.200-208.

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Taman Wisata Alam (TWA) Jering Menduyung merupakan salah satu hutan konservasi Bangka Belitung yang terletak di Kabupaten Bangka Barat. Pada kawasan ini mempunyai hutan mangrove primer yang mendominasi seluas 1209,7 Ha dari seluruh tutupan lahan. Selain itu, juga terdapat ekosistem hutan rawa 405,519 Ha dan hutan belukar rawa 478,709 Ha. Hutan rawa air tawar pada beberapa tahun terakhir keadaan vegetasi mengalami banyak gangguan seperti adanya aktivitas pertanian. Penelitian ini dilakukan untuk menganalisis tingkat keanekaragaman vegetasi hutan rawa air tawar di TWA Jering Menduyung. Metode analisis vegetasi menggunakan metode kombinasi antara metode jalur dan metode garis berpetak, sedangkan penempatan jalur menggunakan metode purposive sampling. Hasil penelitian ini menunjukkan bahwa hutan rawa air tawar memiliki 25 jenis tumbuhan yang termasuk kedalam 19 famili. Famili Rubiaceae merupakan jenis yang paling banyak, diantaranya yaitu jenis Ixora paludosa (Blume) Kurz, Psychotria sp., Oxyceros longiflorus (Lam.) T.Yamaz, Psychotria sp.. Melaleuca leucadendron L merupakan spesies yang mendominasi pada tingkat pertumbuhan pancang (115,64%), tiang (300%) dan pohon (300%). Sementara tingkat semai, spesies yang mendominasi adalah Cyperus sp. (58,62%). Indeks keanekaragaman Shannon-Weiner yang ditemukan tertinggi berkisar anatara 1,591-2,197 yang ditemukan pada tingkat semai dan pancang. Nilai indeks keanekaragaman Shannon-Weiner pada tingkat tiang dan pohon <1. Distribusi spesies berdasarkan indeks kemerataan Evennes untuk semua tingkat pertumbuhan (semai, pancang, tiang dan pohon) di hutan rawa air tawar menunjukkan distribusi spesies yang tidak sama (0-0,792). Stategi yang tepat dalam pengelolaan hutan rawa air tawar TWA Jerieng Menduyung ini melalui pendekatan partisipatif pada tingkat lanskap untuk perencanaan pengelolaan ekosistem hutan yang efektif dan berkelajutan.

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Lu, Y. H., K. Chu y Y. G. Shen. "The Ti-B-N System: Nanocomposite nc-TiN/a-(TiB2, BN) and Nano-Multilayer nc-TiN/a-TiBN Thin Films". Journal of Nanoscience and Nanotechnology 8, n.º 5 (1 de mayo de 2008): 2713–18. http://dx.doi.org/10.1166/jnn.2008.18301.

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The nanostructures and mechanical properties of nanocomposite nc-TiN/a-(TiB2, BN) and nanostructured multilayers nc-TiN/a-TiBN were investigated using X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), microindentation, and stress measurements. It was found that the monolayer Ti-B-N thin films consisted of nanometer-sized crystalline (nc-) Ti(N, B) embedded into amorphous (a-) (TiB2, BN) matrix. When B content was below ∼16 at.%, two different-sized nanocrystallites with mean grain sizes of ∼3 and 9 nm respectively were embedded in a-TiB2. With increasing B incorporation (>∼27 at.%), more uniform nanograins was embedded a-(TiB2, BN). Incorporation of B not only decreased the size of nanocrystallites, but also gave rise to twinning deformation in nanocrystallites. A maximum hardness of ∼44 GPa was achieved at B content of 19 at.%. It was also found that the nanostructure and mechanical behaviors of nc-TiN/a-TiBN multilayers was dependent on the modulation length (bilayer thickness Λ). Decrease of Λ made the preferred orientation of nc-TiN gradually transform from (200) to (111). A maximum hardness of ∼30 GPa was achieved at Λ = 1.8 nm. Deflection from this Λ value decreased hardness. By contrast, the residual compressive stress value monotonically increased with decrease of Λ. The enhancement of the hardness was due to the coherent stresses and the structural barriers to dislocation motion in the interface.

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Vladescu, A., A. Kiss, A. Popescu, M. Braic, M. Balaceanu, V. Braic, I. Tudor, C. Logofatu, C. C. Negrila y R. Rapeanu. "Influence of Bilayer Period on the Characteristics of Nanometre-Scale ZrN/TiAlN Multilayers". Journal of Nanoscience and Nanotechnology 8, n.º 2 (1 de febrero de 2008): 717–21. http://dx.doi.org/10.1166/jnn.2008.d218.

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In the last decade, considerable research effort was directed to the deposition of multilayer films with layer thicknesses in the nanometer range (superlattice coatings), in order to increase the performance of various cutting tools and machine parts. The goal of the present work was to investigate the main microstructural, mechanical and wear resistance characteristics of a superlattice coating, consisting of alternate multilayer ZrN/TiAlN films, with various bilayer periods (5÷20 nm). The coatings were deposited by the cathodic arc method on Si, plain carbon steel and high speed steel substrates to be used as wear resistance surfaces. The multilayer structures were prepared by using shutters placed in front of each cathode (Zr and Ti + Al). The characteristics of multilayer structures (elemental and phase composition, texture, Vickers microhardness, thickness, adhesion, and wear resistance) were determined by using various techniques (AES, XPS, XRD, microhardness measurements, scratch, and tribological tests). A comparison with the properties of ZrN and TiAlN single-layer coatings was carried out.

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42

Susiani, Susiani y Harsojo Harsojo. "Fabrikasi Fiber PVA Yang Memuat Partikel TiO2 Anatase Dengan Metode Elektrospining Dan Karakteristiknya". JURNAL ILMU FISIKA | UNIVERSITAS ANDALAS 9, n.º 1 (23 de marzo de 2017): 33–42. http://dx.doi.org/10.25077/jif.9.1.33-42.2017.

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Fiber PVA yang memuat partikel nano TiO2 anatase telah berhasil dibuat dengan metode elektrospining. Fiber tersebut dibuat dari larutan yang merupakan campuran serbuk nano TiO2 anatase dalam 10% larutan PVA dengan rasio TiO2/PVA terbesar mencapai 60%. Proses elektrospining dilakukan pada tegangan 15 kV dengan jarak ujung anoda ke kolektor (TCD) sejauh 15 cm. Hasil analisis SEM diameter fiber dari tiap-tiap variasi rasio massa menunjukan perubahan rasio TiO2/PVA berpengaruh terhadap diameter fiber. Perlakuan pemanasan pada suhu 300pada fiber tidak mengubah fase kristalin TiO2 dan juga tidak memperlihatkan pengaruh yang signifikan terhadap diameter fiber. Namun demikian perlakuan panas tersebut dapat mereduksi ukuran partikel TiO2. Fiber yang dihasilkan mempunyai rentang diameter dari 100 -700 nm dan partikel TiO2 yang termuat pada fiber PVA memiliki rentang ukuran partikel 50 -180 nm. Hasil analisis serapan sinar UV menunjukan terjadinya serapan sinar UV pada daerah UVB, dengan demikian fiber hasil elektrospining potensial untuk digunakan sebagai fotokatalis.Kata kunci : Fiber, Polivinil Alkohol, Titanium Oksida, Elektrospining

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Kukkonen, T. "Das Transzendentale bei Ibn Sina. Zur Metaphysik als Wissenschaft erster Begriffs- und Urteilsprinzipien * By TIANA KOUTZAROVA". Journal of Islamic Studies 24, n.º 2 (6 de marzo de 2013): 201–4. http://dx.doi.org/10.1093/jis/ett010.

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Idris, Muhamad Husni, Sitti Latifah, Irwan Mahakam Lesmono Aji, Endah Wahyuningsih, Indriyatno Indriyatno y Rima Vera Ningsih. "Studi Vegetasi dan Cadangan Karbon di Kawasan Hutan dengan Tujuan Khusus (KHDTK) Senaru, Bayan Lombok Utara". Jurnal Ilmu Kehutanan 7, n.º 1 (23 de abril de 2015): 25. http://dx.doi.org/10.22146/jik.6135.

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Penelitian pada Kawasan Hutan Dengan Tujuan Khusus (KHDTK) (Hutan Pendidikan) ± 225,7 ha di Desa Senaru, Kabupaten Lombok Utara bertujuan untuk mengetahui potensi vegetasi dan cadangan karbon tersimpan. Tutupan alami KHDTK Senaru berubah akibat pemanfaatan kayu 1993, penanaman sengon dan mahoni 1996, penanaman gaharu 1998-2001, dan saat ini pemanfaatan dengan sistem agroforestri. Populasi dalam penelitian ini adalah areal KHDTK Senaru yang dikelola intensif oleh masyarakat (± 120 ha), yang ditentukan secara sengaja. Sampel dengan intensitas 1% dan terbagi dalam 30 plot ukuran 20x20 m ditentukan secara random sampling. Analisis data meliputi analisis vegetasi, cadangan karbon atas permukaan tanah dan karbon tanah. Hasil penelitian menunjukkan bahwa terdapat 32 spesies. Pada tingkat semai, pancang, tiang dan pohon ditemukan masing-masing 10, 8, 17 dan 20 spesies. Dua spesies dengan Index Nilai Penting (INP) tertinggi untuk semai dan pancang adalah kopi dan kakao, dengan INP pada tingkat semai sebesar 120,3 dan 34,2 dan pada tingkat pancang sebesar 146,1 dan 92,5. Dadap dan sengon memiliki INP tertinggi pada tingkat tiang dan pohon, dengan INP pada tingkat tiang sebesar 77,9 dan 48,7, dan pada tingkat pohon sebesar 87,1 dan 79,9. Cadangan karbon rata-rata 126,41 ton/ha, yang terdiri atas karbon tingkat pancang (3,36 ton C/ha), tiang (9,32 ton C/ha), pohon (70,61 ton C/ha), tumbuhan bawah tegakan (0,13 ton C/ha), seresah (0,29 ton C/ha) dan tanah (42,7 ton C/ha). Hasil penelitian dapat menjadi masukan dalam pengembangan model pengelolaan KHDTK Senaru dan bahan evaluasi di masa mendatang, dan secara umum dapat menambah informasi sumberdaya hutan yang sudah ada saat ini.Katakunci: hutan, vegetasi, cadangan karbon, Senaru Lombok A Study on the Vegetation and Carbon Stocks of the Special Purpose Forest (KHDTK) of Senaru Village, Northern LombokAbstractStudy was conducted in Forest for Special Purpose (Education Forest) ±225.7 ha in Senaru Village, North Lombok. The study was aimed to determine the potential of vegetation and carbon stocks. Land cover of study area was changed due to the timber management in 1993, planting mahogany and sengon in 1996, planting Aquilaria spin 1998-2001, and currently the implementation of agroforestry. Population for this study was the area of education forest intensively utilized by farmer (±120 ha). Sampling was determined by means of random with the intensity of 1% and distributed into 30 plots of 20x20m. Data analysis included analysis of vegetation, above ground carbon and soil carbon stock. The result shows that 32 species were found. There were 10, 8, 17 and 20 species of vegetation for seedlings, saplings, poles and trees, respectively. The first two highest Important Value Index (IVI) for seedling and saplings were Coffea sp and Theobroma sp, where the IVI for seedling was 120.3 and 34.2, while for saplings were 146.1 and 92.5. Erytrhina sp and Pharaseriantes sp were the two highest IVI for poles and trees, where the IVI for poles was 77.9 and 48.7, while for trees was 87.1 and 79.9, respectively. Carbon stock of study area was 126.41 ton C/ha, which was differentiated into carbon stock for saplings (3.36 ton C/ha), pole (9.32 ton C/ha), trees (70.61 ton C/ha), understory (0.13 ton C/ha), litter (0.29 ton C/ha) and soil (42.7 ton C/ha). The results of this study could be an input in develoving a model of Senaru educational forest as wells as future evaluation. Besides, it could enrich the existing information about forest resources.

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Kurniawan, Wawan. "ANALISIS PEMBENTUKAN PORTOFOLIO OPTIMAL SAHAM-SAHAM DI JAKARTA ISLAMIC INDEX (JII) DENGAN MENGGUNAKAN MODEL INDEKS TUNGGAL". JURNAL ECONOMINA 2, n.º 6 (8 de junio de 2023): 1143–64. http://dx.doi.org/10.55681/economina.v2i6.550.

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Penelitian ini bertujuan untuk mengetahui portofolio efisien yang memberikan return tertinggi dengan risiko tertentu atau return tertentu dengan risiko terendah dan besarnya proporsi dana dari masing-masing saham dalam pembentukan portofolio optimal. Dari sekumpulan kandidat portofolio efisien ini terdapat portofolio optimal. Saham-saham yang diteliti adalah saham-saham yang termasuk dalam Jakarta Islamic Index periode Desember 2016-Mei 2017 dan Juni 2015-Mei 2017. Jumlah saham tiap-tiap periode penelitian ada 30 saham. Dari 30 saham masing-masing periode penelitian terdapat saham pembentuk portofolio optimal periode pertama: UNTR (26%), ASII (20%), TLKM (18%), ADHI (14%), INTP (9%), INDF (8%), UNVR (4%), LPPF (1%), SSMS (1%) dan periode kedua: SMGR (63,96%), LPPF (35,56%), SILO (0,48%), LSIP (0,01%). Apabila dibentuk portofolio optimal sesuai dengan proporsi perhitungan, maka expected return yang dihasilkan masing-masing periode penelitian, yaitu: periode pertama sebesar 0,16% per enam bulan lebih besar dibanding dengan expected return market (IHSG) sebesar 0,09% per enam bulan dan periode kedua sebesar 353,73% per dua tahun lebih besar dibanding dengan expected return market (IHSG) sebesar 0,02% per dua tahun.

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46

Zhang, Jian, Ning Tian y Malcolm M. Slaughter. "Neuronal Discriminator Formed by Metabotropic γ-Aminobutyric Acid Receptors". Journal of Neurophysiology 80, n.º 6 (1 de diciembre de 1998): 3365–68. http://dx.doi.org/10.1152/jn.1998.80.6.3365.

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Zhang, Jian, Ning Tian, and Malcolm M. Slaughter. Neuronal discriminator formed by metabotropic γ-aminobutyric acid receptors. J. Neurophysiol. 80: 3365–3368, 1998. Neurotransmitters function in one of two modes, promoting either inhibition or excitation. However, the metabotropic γ-aminobutyric acid receptor (GABABR) system can switch between these modes. In the presence of a small excitatory stimulus, the GABABR mediates a shunting inhibition that suppresses excitation. However, in the presence of a strong excitatory stimulus, the GABABR potentiates the response. This bipartite action is accomplished by linking the GABABR to two electrogenic mechanisms; one activates an outward current and another reduces an outward current. As a consequence, the GABABR serves as a discriminator that reduces the influence of weak signals while augmenting responses to strong signals. In retinal ganglion cells, this mechanism acts to promote the communication of phasic information.

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47

Shi, Jie, Rui Zhou, Shuo Wang, Yuxin Liu, Baorui Tian, Yanhua Liu, YaNan Chen et al. "Abstract 1564: NEU4-mediated desialylation ignites the oncogenic receptors for the dissemination of ovarian carcinoma". Cancer Research 84, n.º 6_Supplement (22 de marzo de 2024): 1564. http://dx.doi.org/10.1158/1538-7445.am2024-1564.

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Abstract Background: Glycosylation profoundly influences the interactions between cancer cells and microenvironmental stromal cells during the peritoneal disseminated metastasis of ovarian carcinoma (OC), which is the major cause of cancer-related death. Although the characteristic cancer glycoconjugates are widely used as biomarkers for cancer diagnosis, our knowledge about cancer glycome remains quite fragmented due to the technique limitations in analyzing glycan chains with tremendous structural and functional heterogeneity. Method: Given the dysregulated cancer glycome is defined by the altered glycosylation machinery, here we performed a systematic loss-of-function screen on 498 genes involved in glycosylation for key regulators of OC dissemination. We identified neuraminidase 4 (NEU4), an enzyme capable of hydrolyzing terminal sialic acid from glycoconjugates, as a vital peritoneal dissemination-promoting modifier of OC glycome. What’s more, we also identified membrane proteins whose sialylation was able to be modified by NEU4 in OC cells by pull down and mass spectrum to investigate the functional significance of NEU4-mediated desialylation. Results: In human patients with high-grade serous OC (HGSOC), increased NEU4 was detected in the disseminated OC cells when compared with that in the primary tumor cells, which significantly correlated with the worse survival. Among three alternative splice-generated isoforms of human NEU4, we revealed that only the plasma membrane-localized NEU4 isoform 2 (NEU4-iso2) and intracellular isoform 3 promoted the peritoneal dissemination of OC by enhancing the cell motility and epithelial-mesenchymal transition. We also identified NEU4-iso2-regulated cell surface glycoproteome and found that NEU4-iso2 desialylated the epithelial growth factor receptor (EGFR), in particular at N196 residue, for the hyperactivation of EGFR and its downstream tumor-promoting signaling cascades. Conclusion: Our results provide new insights into how the OC glycome is dysregulated by NEU4 during OC progression and reveals a functionally important glycosite on EGFR for its abnormal activation in cancer. Citation Format: Jie Shi, Rui Zhou, Shuo Wang, Yuxin Liu, Baorui Tian, Yanhua Liu, YaNan Chen, Taoyu Hu, Yuhao Mu, Shufan Wang, Xintao Shao, Jie Yan, Pengpeng Qu, Wei Ding, Shuang Yang, Yi Shi, Jia Li, Longlong Wang. NEU4-mediated desialylation ignites the oncogenic receptors for the dissemination of ovarian carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1564.

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Liu, Hao−Lan, Tengfei Zhu, Xinyi Wen, Qing Zhao, Yao Chen, Yun−Zi Wang, Jian Li y Shunde Su. "Chemical and Microbial Differences of Root and Rhizosphere Soil among Different Provenances of Fokienia hodginsii". Forests 15, n.º 6 (7 de junio de 2024): 1005. http://dx.doi.org/10.3390/f15061005.

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Aims: Fokienia hodginsii is a threatened conifer tree species, known as the dominant nursery-grown species capable of colonizing the challenging woodland environments in southern China due to its strong root penetrating ability. The ecological phenotype of Fokienia hodginsii is not well documented during its breeding process, which limits the potential planting area and its ecological function. This study aims to understand how Fokienia hodginsii associates with microbes to conduct its key ecological function and provide a theoretical basis for further improving the forest nursery management of Fokienia hodginsii. Methods: This study explored the ecological traits of 11 main Fokienia hodginsii provenances in a homogeneous garden experiment by analyzing their nutrient utilization strategies and associated microbial features in the rhizosphere soil and roots. Results: The study found that the paramount difference in the rhizosphere soil among provenances is in Ca and Fe content. Some microbial communities, namely Crenarchaeota, Verrucomicrobiota, and Desulfobacterota, were positively correlated with the amounts of the soil nutrient elements, whereas Abditibacteriota and Dependentiae were negatively correlated. The abundance of N- and Fe-related bacteria in the Fu Jian Chang Ting (FJCT) provenance was significantly higher than that in other provenances, while the C-, P-, K-, and Mg-related fungal communities, respectively, had higher abundances in the FJCT, Fu Jian Long Yan (FJLY), Fu Jian Gu Tian (FJGT), and Fu Jian Xian You (FJXY) provenances than the others. The impacts of the Gui Zhou Li Ping (GZLP), Hu Nan Dao Xian (HNDX), Jiang Xi Shang Yao (JXSY), and Guang Dong Shi Xing (GDSX) provenances on the rhizosphere soil are similar, but the differences in nutrient utilization arise from the plant itself. Conversely, the root nutrient contents of the FJCT, Fu Jian You Xi (FJYX), Fu Jian An Xi (FJAX), FJLY, Fu Jian De Hua (FJDH), FJGT, and FJXY provenances are highly correlated with soil nutrient features. Conclusions: For the native provenances, their economic traits are better than the exotic provenances. The native provenances are more sensitive to local soil conditions, so they should benefit more from human interventions, rendering them more suitable for artificial cultivation. The growth of the exotic provenances is less affected by the soil environment, making them better suited for the ecological transformation of forest stands and soil improvement.

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Amriarni, A., Budi Hendrarto y Agus Hadiyarto. "BIOAKUMULASI LOGAM BERAT TIMBAL (Pb) DAN SENG (Zn) PADA KERANG DARAH (Anadara granosa L.) dan KERANG BAKAU (Polymesoda bengalensis L.) DI PERAIRAN TELUK KENDARI". Jurnal Ilmu Lingkungan 9, n.º 2 (28 de octubre de 2012): 45. http://dx.doi.org/10.14710/jil.9.2.45-50.

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Perkembangan wilayah pesisir Teluk Kendari cukup pesat dengan berbagai macam aktivitas baik berupa jasa kelautan seperti pelabuhan untuk pelayaran dan perikanan maupun kegiatan-kegiatan di sekitar pantai seperti pemukiman, industri, usaha dan pertambakan. Adanya logam berat di perairan, berbahaya baik secara langsung terhadap kehidupan kerang darah (Anadara. granosa) dan kerang bakau (Polymesoda bengalensis), maupun efeknya secara tidak langsung terhadap kesehatan manusia. Penelitian ini bertujuan untuk menganalisis kandungan logam berat Pb dan Zn pada air, sedimen, dan jaringan kerang dan mengkaji faktor bioakumulasi logam berat Pb dan Zn pada dua jenis kerang. Sampel air, sedimen dan kerang diambil pada kedua lokasi pengambilan kerang, tiap lokasi 3 titik pengambilan dengan 3 kali ulangan analisis. Hasil Penelitian menunjukkan bahwa logam Pb dan Zn di air pada tiap lokasi telah melampau baku mutu, kadar tertinggi masing-masing 0,018 mg/L dan 0,793 mg/L, sedangkan pada sedimen tertinggi masing-masing 0,823 mg/Kg dan 6,919 mg/Kg, dan pada jaringan kerang menunjukan hasil bahwa kerang ukuran besar mengandung logam Pb dan Zn lebih tinggi, masing-masing 1,750 dan 9,863 mg/Kg. (sedimen dan kerang belum melampau baku mutu). Nilai BCFo-w logam Pb tertinggi 119,20 pada kerang bakau dan Zn tertinggi 35,99 pada kerang darah. Berdasarkan kategori nilai IFK (BCF) untuk logam Pb dan Zn termasuk dalam kategori rendah hingga sedang.

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Yin, Jingwei. "Zhu De's fighting spirit into the ideological and political education path of college students". Journal of Education and Educational Research 2, n.º 1 (1 de marzo de 2023): 84–86. http://dx.doi.org/10.54097/jeer.v2i1.5544.

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Zhu De is a revolutionary of the older generation of the Communist Party of China, his military life, reflecting the communist character of hard struggle. The scientific connotation of Zhu De's fighting spirit includes the oath of iron and blood, the heroic struggle for the communist ideal, the fearlessness of fighting in the front line, the simplicity like Tian Jia weng, the persistence of hard work and plain simplicity and the comfort of fighting, and the optimism of life. Carrying forward Zhu De's fighting spirit is conducive to reshaping the fighting power of contemporary college students to cope with the challenges of The Times. Therefore, colleges and universities can integrate Zhu De's struggle spirit into classroom teaching, so that college students know the struggle process, Zhu De's struggle spirit into the frustration education, let college students learn from the struggle, Zhu De's struggle spirit into practical education, so that college students carry forward the spirit of struggle.

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