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Artículos de revistas sobre el tema "Isocryptolepine"

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Autor: Grafiati
Publicado: 6 de septiembre de 2023

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1

Wang, Ning, Marta Świtalska, Li Wang, Elkhabiry Shaban, Md Imran Hossain, Ibrahim El Tantawy El Sayed, Joanna Wietrzyk y Tsutomu Inokuchi. "Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity". Molecules 24, n.º 11 (5 de junio de 2019): 2121. http://dx.doi.org/10.3390/molecules24112121.

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Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
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2

Murray, Paul E., Keith Mills y John A. Joule. "A Synthesis of Isocryptolepine". Journal of Chemical Research, n.º 7 (1998): 377. http://dx.doi.org/10.1039/a801313f.

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3

Pousset, Jean-Louis, Marie-Therese Martin, Akino Jossang y Bernard Bodo. "Isocryptolepine from Cryptolepis sanguinolenta". Phytochemistry 39, n.º 3 (junio de 1995): 735–36. http://dx.doi.org/10.1016/0031-9422(94)00925-j.

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4

Aksenov, Alexander V., Dmitrii A. Aksenov, Georgii D. Griaznov, Nicolai A. Aksenov, Leonid G. Voskressensky y Michael Rubin. "Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-c]quinolines". Organic & Biomolecular Chemistry 16, n.º 23 (2018): 4325–32. http://dx.doi.org/10.1039/c8ob00588e.

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5

Murray, Paul E., Keith Mills y John A. Joule. "ChemInform Abstract: A Synthesis of Isocryptolepine." ChemInform 30, n.º 15 (16 de junio de 2010): no. http://dx.doi.org/10.1002/chin.199915254.

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6

Akitake, Masahiro, Shizuki Noda, Kohei Miyoshi, Motohiro Sonoda y Shinji Tanimori. "Access to γ-Carbolines: Synthesis of Isocryptolepine". Journal of Organic Chemistry 86, n.º 24 (6 de diciembre de 2021): 17727–37. http://dx.doi.org/10.1021/acs.joc.1c02026.

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7

Kraus, George A. y Haitao Guo. "A direct synthesis of neocryptolepine and isocryptolepine". Tetrahedron Letters 51, n.º 31 (agosto de 2010): 4137–39. http://dx.doi.org/10.1016/j.tetlet.2010.05.141.

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8

Dubovitskii, S. V., O. S. Radchenko y V. L. Norikov. "Synthesis of isocryptolepine, an alkaloid fromCryptolepis sanguinolenta". Russian Chemical Bulletin 45, n.º 11 (noviembre de 1996): 2656–57. http://dx.doi.org/10.1007/bf01431136.

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9

Helgeland, Ida y Magne Sydnes. "A Concise Synthesis of Isocryptolepine by C–C Cross-Coupling Followed by a Tandem C–H Activation and C–N Bond Formation". SynOpen 01, n.º 01 (marzo de 2017): 0041–44. http://dx.doi.org/10.1055/s-0036-1590807.

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Isocryptolepine (1), a potent antimalarial natural product, was prepared in three steps from 3-bromoquinoline and 2-aminophenylboronic acid hydrochloride. The key transformations were a Suzuki–Miyaura cross-coupling reaction followed by a palladium-initiated intramolecular C–H activation/C–N bond formation between an unprotected amine and an aromatic C–H group. The two key reactions can also be performed in one pot.
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10

Whittell, Louise R., Kevin T. Batty, Rina P. M. Wong, Erin M. Bolitho, Simon A. Fox, Timothy M. E. Davis y Paul E. Murray. "Synthesis and antimalarial evaluation of novel isocryptolepine derivatives". Bioorganic & Medicinal Chemistry 19, n.º 24 (diciembre de 2011): 7519–25. http://dx.doi.org/10.1016/j.bmc.2011.10.037.

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11

Li, Jun-cai, Ren-xuan Wang, Yu Sun, Jia-kai Zhu, Guan-fang Hu, Yu-ling Wang, Rui Zhou et al. "Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives". Bioorganic Chemistry 92 (noviembre de 2019): 103266. http://dx.doi.org/10.1016/j.bioorg.2019.103266.

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12

Rujimongkon, Kitiya, Mathirut Mungthin, Jumreang Tummatorn, Sumate Ampawong, Poom Adisakwattana, Usa Boonyuen y Onrapak Reamtong. "Proteomic analysis of Plasmodium falciparum response to isocryptolepine derivative". PLOS ONE 14, n.º 8 (8 de agosto de 2019): e0220871. http://dx.doi.org/10.1371/journal.pone.0220871.

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13

Grellier, Phillippe, Lobo Ramiaramanana, Valérie Millerioux, Eric Deharo, Joseph Schrével, François Frappier, François Trigalo, Bernard Bodo y Jean-Louis Pousset. "Antimalarial Activity of Cryptolepine and Isocryptolepine, Alkaloids Isolated fromCryptolepis sanguinolenta". Phytotherapy Research 10, n.º 4 (junio de 1996): 317–21. http://dx.doi.org/10.1002/(sici)1099-1573(199606)10:4<317::aid-ptr858>3.0.co;2-0.

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14

DUBOVITSKII, S. V., O. S. RADCHENKO y V. L. NOVIKOV. "ChemInform Abstract: Synthesis of Isocryptolepine, an Alkaloid from Cryptolepis sanguinolenta." ChemInform 28, n.º 17 (4 de agosto de 2010): no. http://dx.doi.org/10.1002/chin.199717217.

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15

Rodphon, Warabhorn, Pavitra Laohapaisan, Nantamon Supantanapong, Onrapak Reamtong, Lukana Ngiwsara, Kriengsak Lirdprapamongkol, Charnsak Thongsornkleeb et al. "Synthesis of Isocryptolepine‐Triazole Adducts and Evaluation of Their Cytotoxic Activity". ChemMedChem 16, n.º 24 (14 de octubre de 2021): 3750–62. http://dx.doi.org/10.1002/cmdc.202100554.

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16

Aksenov, Alexander V., Dmitrii A. Aksenov, Naila A. Orazova, Nicolai A. Aksenov, Georgii D. Griaznov, Annelise De Carvalho, Robert Kiss, Véronique Mathieu, Alexander Kornienko y Michael Rubin. "One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine". Journal of Organic Chemistry 82, n.º 6 (8 de marzo de 2017): 3011–18. http://dx.doi.org/10.1021/acs.joc.6b03084.

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17

T. Parvatkar, Prakash, Perunninakulath S. Parameswaran y Santosh G. Tilve. "Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine". Current Organic Chemistry 15, n.º 7 (1 de abril de 2011): 1036–57. http://dx.doi.org/10.2174/138527211794785118.

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18

Thobokholt, Elida N., Enrique L. Larghi, Andrea B. J. Bracca y Teodoro S. Kaufman. "Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid". RSC Advances 10, n.º 32 (2020): 18978–9002. http://dx.doi.org/10.1039/d0ra03096a.

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19

Aggrey, Mike Okweesi, Hui-Hui Li, Wen-Qiong Wang, Weibin Song, Yiping Wang y Li-Jiang Xuan. "Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells". Revista Brasileira de Farmacognosia 28, n.º 6 (noviembre de 2018): 654–57. http://dx.doi.org/10.1016/j.bjp.2018.08.008.

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20

Kraus, George, Haitao Guo, Ganesh Kumar, Gerald Pollock III, Heather Carruthers, Divya Chaudhary y Jonathan Beasley. "A Flexible Synthesis of Indoles from ortho-Substituted Anilines: A Direct Synthesis of Isocryptolepine". Synthesis 2010, n.º 08 (24 de marzo de 2010): 1386–93. http://dx.doi.org/10.1055/s-0029-1218706.

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21

Kraus, George, Haitao Guo, Ganesh Kumar, Heather Carruthers, Divya Chaudhary y Jonathan Beasley. "A Flexible Synthesis of Indoles from ortho-Substituted Anilines: A Direct Synthesis of Isocryptolepine". Synthesis 2010, n.º 14 (julio de 2010): 2496. http://dx.doi.org/10.1055/s-0029-1218853.

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22

Parvatkar, Prakash T., Perunninakulath S. Parameswaran y Santosh G. Tilve. "ChemInform Abstract: Isolation, Biological Activities, and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine, and Neocryptolepine". ChemInform 42, n.º 38 (25 de agosto de 2011): no. http://dx.doi.org/10.1002/chin.201138237.

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23

Aroonkit, Pasuk, Charnsak Thongsornkleeb, Jumreang Tummatorn, Suppachai Krajangsri, Mathirut Mungthin y Somsak Ruchirawat. "Synthesis of isocryptolepine analogues and their structure–activity relationship studies as antiplasmodial and antiproliferative agents". European Journal of Medicinal Chemistry 94 (abril de 2015): 56–62. http://dx.doi.org/10.1016/j.ejmech.2015.02.047.

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24

Kraus, George A., Haitao Guo, Ganesh Kumar, Gerald III Pollock, Heather Carruthers, Divya Chaudhary y Jonathan Beasley. "ChemInform Abstract: A Flexible Synthesis of Indoles from ortho-Substituted Anilines: A Direct Synthesis of Isocryptolepine." ChemInform 41, n.º 35 (5 de agosto de 2010): no. http://dx.doi.org/10.1002/chin.201035120.

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25

Murugan, Arumugavel, Shinde Vidyacharan, Ruma Ghosh y Duddu S. Sharada. "Metal-Free Regioselective Dual C-H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues". ChemistrySelect 2, n.º 12 (24 de abril de 2017): 3511–15. http://dx.doi.org/10.1002/slct.201700263.

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26

Håheim, Katja S., Emil Lindbäck, Kah Ni Tan, Marte Albrigtsen, Ida T. Urdal Helgeland, Clémence Lauga, Théodora Matringe et al. "Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioisomers for Antimalarial, Antiproliferative and Antimicrobial Activities". Molecules 26, n.º 11 (30 de mayo de 2021): 3268. http://dx.doi.org/10.3390/molecules26113268.

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A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 µM; 9b: MBIC = 100 µM).
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27

Hayashi, Kaori, Tominari Choshi, Kyoko Chikaraishi, Aimi Oda, Rikako Yoshinaga, Noriyuki Hatae, Minoru Ishikura y Satoshi Hibino. "A novel total synthesis of isocryptolepine based on a microwave-assisted tandem Curtius rearrangement and aza-electrocyclic reaction". Tetrahedron 68, n.º 22 (junio de 2012): 4274–79. http://dx.doi.org/10.1016/j.tet.2012.03.055.

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28

Håheim, Katja S., Ida T. Urdal Helgeland, Emil Lindbäck y Magne O. Sydnes. "Mapping the reactivity of the quinoline ring-system – Synthesis of the tetracyclic ring-system of isocryptolepine and regioisomers". Tetrahedron 75, n.º 21 (mayo de 2019): 2949–57. http://dx.doi.org/10.1016/j.tet.2019.04.026.

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29

Hingane, Dattatray G. y Radhika S. Kusurkar. "An efficient new route towards biologically active isocryptolepine and γ-carboline derivatives using an intramolecular thermal electrocyclization strategy". Tetrahedron Letters 52, n.º 28 (julio de 2011): 3686–88. http://dx.doi.org/10.1016/j.tetlet.2011.05.049.

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30

Chen, Chen, Yuebo Wang, Xiaonan Shi, Wan Sun, Jinghui Zhao, Yan-Ping Zhu, Liying Liu y Bolin Zhu. "Palladium-Catalyzed C-2 and C-3 Dual C–H Functionalization of Indoles: Synthesis of Fluorinated Isocryptolepine Analogues". Organic Letters 22, n.º 11 (27 de mayo de 2020): 4097–102. http://dx.doi.org/10.1021/acs.orglett.0c01159.

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31

Uchuskin, Maxim G., Arkady S. Pilipenko, Olga V. Serdyuk, Igor V. Trushkov y Alexander V. Butin. "From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives". Organic & Biomolecular Chemistry 10, n.º 36 (2012): 7262. http://dx.doi.org/10.1039/c2ob25836f.

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32

Chen, Xuebing, Peng Sun, Jinyi Xu, Xiaoming Wu, Lingyi Kong, Hequan Yao y Aijun Lin. "Construction of indoloquinolinones via Pd(II)-catalyzed tandem CC/CN bond formation: application to the total synthesis of isocryptolepine". Tetrahedron Letters 55, n.º 51 (diciembre de 2014): 7114–17. http://dx.doi.org/10.1016/j.tetlet.2014.11.008.

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33

Hostyn, Steven, Bert U. W. Maes, Luc Pieters, Guy L. F. Lemière, Péter Mátyus, György Hajós y Roger A. Dommisse. "Synthesis of the benzo-β-carboline isoneocryptolepine: the missing indoloquinoline isomer in the alkaloid series cryptolepine, neocryptolepine and isocryptolepine". Tetrahedron 61, n.º 6 (febrero de 2005): 1571–77. http://dx.doi.org/10.1016/j.tet.2004.11.073.

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34

Agarwal, Piyush K., Devesh Sawant, Sunil Sharma y Bijoy Kundu. "New Route to the Synthesis of the Isocryptolepine Alkaloid and Its Related Skeletons Using a Modified Pictet-Spengler Reaction". European Journal of Organic Chemistry 2009, n.º 2 (enero de 2009): 292–303. http://dx.doi.org/10.1002/ejoc.200800929.

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35

Mahajan, Pankaj S., Vivek T. Humne, Subhash D. Tanpure y Santosh B. Mhaske. "Radical Beckmann Rearrangement and Its Application in the Formal Total Synthesis of Antimalarial Natural Product Isocryptolepine via C–H Activation". Organic Letters 18, n.º 14 (5 de julio de 2016): 3450–53. http://dx.doi.org/10.1021/acs.orglett.6b01634.

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36

Aksenov, Nicolai A., Alexander V. Aksenov, Alexander Kornienko, Annelise De Carvalho, Véronique Mathieu, Dmitrii A. Aksenov, Sergei N. Ovcharov, Georgii D. Griaznov y Michael Rubin. "A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities". RSC Advances 8, n.º 64 (2018): 36980–86. http://dx.doi.org/10.1039/c8ra08155g.

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37

Indu, Satrajit, Parthasarathi Subramanian y Krishna P. Kaliappan. "Transition-Metal-Catalyzed Selective Cyclization Strategy to 2-Substituted Benzofurans and Indoles en Route to the Oxa Analogues of Isocryptolepine". European Journal of Organic Chemistry 2014, n.º 32 (29 de septiembre de 2014): 7193–202. http://dx.doi.org/10.1002/ejoc.201402869.

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38

Uchuskin, Maxim G., Arkady S. Pilipenko, Olga V. Serdyuk, Igor V. Trushkov y Alexander V. Butin. "ChemInform Abstract: From Biomass to Medicines. A Simple Synthesis of Indolo[3,2-c]quinolines, Antimalarial Alkaloid Isocryptolepine, and Its Derivatives." ChemInform 44, n.º 8 (19 de febrero de 2013): no. http://dx.doi.org/10.1002/chin.201308150.

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39

Indu, Satrajit, Parthasarathi Subramanian y Krishna P. Kaliappan. "ChemInform Abstract: Transition-Metal-Catalyzed Selective Cyclization Strategy to 2-Substituted Benzofurans and Indoles en Route to the Oxa Analogues of Isocryptolepine." ChemInform 46, n.º 16 (abril de 2015): no. http://dx.doi.org/10.1002/chin.201516147.

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40

Chen, Xuebing, Peng Sun, Jinyi Xu, Xiaoming Wu, Lingyi Kong, Hequan Yao y Aijun Lin. "ChemInform Abstract: Construction of Indoloquinolinones via Pd(II)-Catalyzed Tandem C-C/C-N Bond Formation: Application to the Total Synthesis of Isocryptolepine." ChemInform 46, n.º 18 (16 de abril de 2015): no. http://dx.doi.org/10.1002/chin.201518218.

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41

Wang, Ning, Kathryn J. Wicht, Kento Imai, Ming-qi Wang, Tran Anh Ngoc, Ryo Kiguchi, Marcel Kaiser, Timothy J. Egan y Tsutomu Inokuchi. "Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11". Bioorganic & Medicinal Chemistry 22, n.º 9 (mayo de 2014): 2629–42. http://dx.doi.org/10.1016/j.bmc.2014.03.030.

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42

Kirsch, Gilbert, Eslam El-Sawy y Ahmed Abdelwahab. "Utilization of 1H-Indole-3-carboxaldehyde as a Precursor for the Synthesis of Bioactive Indole Alkaloids". Synthesis 50, n.º 23 (15 de octubre de 2018): 4525–38. http://dx.doi.org/10.1055/s-0037-1610288.

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Indole alkaloids constitute a large class of natural products and their diverse and complex structures have been attributed to potent biological activities such as anticancer, anti-inflammatory, antimicrobial, antimalarial, antiplasmodial and protein kinase inhibition. The isolation of bioactive compounds from natural sources is difficult, costly and an extremely time-consuming process, therefore synthetic pathways are more convenient than natural separation to deliver such compounds in considerable amounts. In this respect, this review provides comprehensive information on the structures and the synthesis of bioactive indole alkaloids utilizing 1H-indole-3-carboxaldehyde and its derivatives as starting compounds. 1 Overview2 Phytoalexins2.1 Brassinin, Cyclobrassinin and Brassitin2.2 1-Methoxybrassinin, 1-Methoxyspirobrassinol and 1-Methoxyspirobrassinin2.3 4-Methoxybrassinin and 4-Methoxycyclobrassinin2.4 Cyclobrassinone2.5 Brassilexin2.6 (S)-(–)-Spirobrassinin2.7 Camalexin3 Bis(indole) Alkaloids: Rhopaladines A–D4 Coscinamides A and B5 α-Cyclopiazonic Acid6 Dipodazine7 Isocryptolepine8 Apparicine9 Carbazole Alkaloids: Mukonine and Clausine E10 Indolmycin11 Conclusion
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43

Schendera, Eva, Lisa‐Natascha Unkel, Phung Phan Huyen Quyen, Gwen Salkewitz, Frank Hoffmann, Alexander Villinger y Malte Brasholz. "Visible‐Light‐Mediated Aerobic Tandem Dehydrogenative Povarov/Aromatization Reaction: Synthesis of Isocryptolepines". Chemistry – A European Journal 26, n.º 1 (27 de noviembre de 2019): 269–74. http://dx.doi.org/10.1002/chem.201903921.

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44

Jonckers, Tim H. M., Bert U. W. Maes, Guy L. F. Lemiere, Geert Rombouts, Luc Pieters, Achiel Haemers y Roger A. Dommisse. "Synthesis of Isocryptolepine via a Pd-Catalyzed “Amination—Arylation” Approach." ChemInform 34, n.º 30 (29 de julio de 2003). http://dx.doi.org/10.1002/chin.200330227.

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45

Morozov, Vyacheslav y Yurii Shklyaev. "Metal‐Free Rapid Diastereoselective Construction of Isocryptolepine Core via Elecrophilic Dearomatization ‐ Inramolecular Michael Addition Sequence". ChemistrySelect 7, n.º 23 (14 de junio de 2022). http://dx.doi.org/10.1002/slct.202201709.

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46

Hostyn, Steven, Bert U. W. Maes, Luc Pieters, Guy L. F. Lemiere, Peter Matyus, Gyoergy Hajos y Roger A. Dommisse. "Synthesis of the Benzo-β-Carboline Isoneocryptolepine: The Missing Indoloquinoline Isomer in the Alkaloid Series Cryptolepine, Neocryptolepine and Isocryptolepine." ChemInform 36, n.º 23 (7 de junio de 2005). http://dx.doi.org/10.1002/chin.200523212.

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47

Agarwal, Piyush K., Devesh Sawant, Sunil Sharma y Bijoy Kundu. "ChemInform Abstract: New Route to the Synthesis of the Isocryptolepine Alkaloid and Its Related Skeletons Using a Modified Pictet-Spengler Reaction." ChemInform 40, n.º 20 (19 de mayo de 2009). http://dx.doi.org/10.1002/chin.200920188.

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48

Mahajan, Pankaj S., Vivek T. Humne, Subhash D. Tanpure y Santosh B. Mhaske. "ChemInform Abstract: Radical Beckmann Rearrangement and Its Application in the Formal Total Synthesis of Antimalarial Natural Product Isocryptolepine via C-H Activation." ChemInform 47, n.º 48 (noviembre de 2016). http://dx.doi.org/10.1002/chin.201648028.

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49

Verma, Kanchan, Yogesh Kumar Tailor, Sarita Khandelwal, Monu Agarwal, Esha Rushell, Sakshi Pathak, Yogita Kumari, Kamlendra Awasthi y Mahendra Kumar. "Synthesis and characterization of terbium doped TiO 2 nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐ c ]quinolines‐ mimetic scaffolds of isocryptolepine". Applied Organometallic Chemistry 34, n.º 10 (8 de junio de 2020). http://dx.doi.org/10.1002/aoc.5836.

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