Literatura académica sobre el tema "INTERFERON SIGNATURE"
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Artículos de revistas sobre el tema "INTERFERON SIGNATURE"
Visan, Ioana. "The interferon signature". Nature Immunology 18, n.º 2 (febrero de 2017): 151. http://dx.doi.org/10.1038/ni.3670.
Texto completoSuspitsin, E. N., R. K. Raupov, E. M. Kuchinskaya y M. M. Kostik. "Analysis of interferon type I signature for differential diagnosis of diseases of the immune system ( review of literature)". Russian Clinical Laboratory Diagnostics 66, n.º 5 (23 de mayo de 2021): 279–84. http://dx.doi.org/10.51620/0869-2084-2021-66-5-279-284.
Texto completoSmith, Michael Alexander, Chia-Chien Chiang, Dominic Sinibaldi, Kamelia Zerrouki, Zerai Manna, Wendy I. White, Mariana J. Kaplan et al. "Using the Circulating Proteome to Assess Type I Interferon Activity in Systemic Lupus Erythematosus". Journal of Immunology 198, n.º 1_Supplement (1 de mayo de 2017): 210.1. http://dx.doi.org/10.4049/jimmunol.198.supp.210.1.
Texto completoRigolet, Muriel, Cyrielle Hou, Yasmine Baba Amer, Jessie Aouizerate, Baptiste Periou, Romain K. Gherardi, Peggy Lafuste y François Jérôme Authier. "Distinct interferon signatures stratify inflammatory and dysimmune myopathies". RMD Open 5, n.º 1 (febrero de 2019): e000811. http://dx.doi.org/10.1136/rmdopen-2018-000811.
Texto completoCarrero, Javier, Boris Calderon, Stephen Ferris y Emil Unanue. "Evaluation of the role of type I interferon to the development of type 1 diabetes. (BA3P.131)". Journal of Immunology 192, n.º 1_Supplement (1 de mayo de 2014): 44.1. http://dx.doi.org/10.4049/jimmunol.192.supp.44.1.
Texto completoAn, Yuanyuan y Hua Duan. "The Comprehensive Analysis of Interferon-Related Prognostic Signature with regard to Immune Features in Ovarian Cancer". Disease Markers 2022 (20 de junio de 2022): 1–24. http://dx.doi.org/10.1155/2022/7900785.
Texto completoGallay, Laure, Guy Mouchiroud y Bénédicte Chazaud. "Interferon-signature in idiopathic inflammatory myopathies". Current Opinion in Rheumatology 31, n.º 6 (noviembre de 2019): 634–42. http://dx.doi.org/10.1097/bor.0000000000000653.
Texto completoRönnblom, Lars y Maija-Leena Eloranta. "The interferon signature in autoimmune diseases". Current Opinion in Rheumatology 25, n.º 2 (marzo de 2013): 248–53. http://dx.doi.org/10.1097/bor.0b013e32835c7e32.
Texto completoVieira, Matheus, Paul Régnier, Anna Maciejewski-Duval, Alexandre Le Joncour, Guillaume Darasse-Jèze, Michelle Rosenzwajg, David Klatzmann, Patrice Cacoub y David Saadoun. "Interferon signature in giant cell arteritis aortitis". Journal of Autoimmunity 127 (febrero de 2022): 102796. http://dx.doi.org/10.1016/j.jaut.2022.102796.
Texto completoGruber, Conor. "Impaired interferon signature in severe COVID-19". Nature Reviews Immunology 20, n.º 6 (30 de abril de 2020): 353. http://dx.doi.org/10.1038/s41577-020-0335-0.
Texto completoTesis sobre el tema "INTERFERON SIGNATURE"
Lincez, Pamela Joan. "MDA5 and a type 1 interferon signature in the development of type 1 diabetes". Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52850.
Texto completoScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Lisney, Anna [Verfasser]. "Analysis of SIGLEC1 as a surrogate marker for a type I interferon signature in autoimmune congenital heart block and primary Sjögren’s syndrome / Anna Lisney". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/120204381X/34.
Texto completoDomaszewska, Teresa. "Unraveling transcript-based variability of host responses to Tuberculosis". Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19829.
Texto completoOver 10 million tuberculosis (TB) cases are being reported annually and the World Health Organization (WHO) estimates that up to the 1/3 of the world population is infected with Mycobacterium tuberculosis (Mtb). Between 5 and 10% of the latently infected individuals develop TB during their lifetime. Yet, despite over 100 years of research since Mtb has been identified, we are not able to define all the factors which are responsible for the different infection outcomes in the hosts. In this thesis I investigate the variability in the response to TB presented by different hosts. In one approach, I collect publicly available transcriptomic datasets from TB patients and healthy donors. Using Gene Set Enrichment Analysis (GSEA) I examine transcriptional profiles of individuals with TB. In particular, focus is brought to interferon (IFN) signaling which has been previously described as crucial for the disease outcome. I show that patients lacking IFN signature are present in the studied cohorts and investigate whether these patients present different phenotype than patients with strong regulation of IFN responses. Moreover, by focusing on patients lacking IFN response I try to unearth mechanisms present in all patient groups but dominated by the signal of IFN response. I show that strong regulation of IFN genes is related to severe pathology in the lungs of TB patients and that it is reflected by the levels of IFN-inducible cytokines in blood of healthy volunteers after vaccination with FLUAD® vaccine. Using Machine Learning (ML) methods, I identify and compare transcriptomic signatures of the patients presenting and lacking the IFN response. In the second approach I study the differences in the transcriptional responses to Mtb infection in human cohorts and two different mouse models. The immunity in infection, inflammation and malignancy differs markedly in man and mouse. Nevertheless, there are elements of immune system which have been conserved between the species. I propose a novel data integration approach which identifies concordant and discordant elements of gene expression regulation in heterologous datasets. The analysis is based on publicly available as well as novel experimental data acquired thanks to collaboration with my colleagues from the Department of Immunology and Microarray Core Facility of Max Planck Institute for Infection Biology (MPIIB). Additionally, I focus on the comparison of human and murine transcriptional responses to TB in whole blood (WB) and in macrophages. The results indicate profound differences between regulation of innate and adaptive immunity in man and mouse upon Mtb infection. I characterize differential regulation of T-cell related genes corresponding to the differences in phenotype between TB high and low susceptible mouse strains and identify the time point of 21 days p.i. of mice as best reflection of transcriptional responses in the studied human cohorts. The implemented approaches facilitate the choice of an appropriate animal model for studies of the human immune response to a particular disease and provide the basis for better understanding of differences in the outcomes of Mtb infection in individual hosts.
Strauß, Romy [Verfasser]. "Der Einfluss von Typ-I-Interferonen auf Leukozyten-Subpopulationen im Blut : ein neuer diagnostischer Ansatz für die Verwendung der Interferon-Signatur als Biomarker beim systemischen Lupus erythematodes / Romy Strauß". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1176632272/34.
Texto completoImgenberg-Kreuz, Juliana. "Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases". Doctoral thesis, Uppsala universitet, Molekylär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310388.
Texto completoOutlioua, Ahmed. "Exploration des cytokines pro-inflammatoires et de l’inflammasome NLRP3 dans les infections intracellulaires : cas de H. pylori et des virus à ARN Gastric IL-1β, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling The Role of Optineurin in Antiviral Type I Interferon Production Possible introduction of Leishmania tropica to urban areas determined by epidemiological and clinical profiles of patients with cutaneous leishmaniasis in Casablanca (Morocco)". Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL029.
Texto completoHelicobacter pylori (H. pylori) is a bacteria that infects the stomach and induces inflammatory gastritis, which can be chronic and progress to gastric cancer. The severity of the infection and its clinical course are associated with various factors including the immune status of the host. The initial inflammatory response to H. pylori infection results in the secretion of a wide range of cytokines, including interleukin-1β (IL-1β), IL-8 and IL-17A. which appear to play a key role in the initiation and progression of gastric cancer. Among these cytokines, IL-1β is a key cytokine during H. pylori infection whose expression is associated with gastric inflammation and carcinogenesis. The production of this cytokine depends on the activation of the inflammasome, in particular the NLRP3 inflammasome. The latter, responsible of the activation of inflammatory processes, is essential for the maintenance of homeostasis against various pathogenic infections such as bacterial and viral infections.The general objective of this work is i) to study the expression and polymorphism of genes for cytokines such as IL-1β, IL-17 and IL-8 in Moroccan patients infected with H. pylori. ii) explore the activation of the NLRP3 inflammasome by H. pylori and determine the mechanisms involved in the activation of this complex by RNA viruses; known as defined activators of NLRP3.Our results underlined a high prevalence of H. pylori and demonstrated a cytokine signature: it can predict metaplasia during the progression of H. pylori infection involving a decrease in IL17A expression in the antrum and increased expression of IL-1β in the fundus. In particular, the genetic polymorphisms of IL-1β (IL-1β -31 and -511) do not appear to influence IL-1β expression significantly.In view of the difficulties encountered in isolating and culturing H. pylori, we used LPS from H. pylori to stimulate the inflammasome. Our results show that the transfection of cells in vitro with bacterial LPS induces the production of IL-1β which appears to be modulated by caspase 4, NOD1 and NOD2. Furthermore, while it is clearly established that RNA viruses induce activation of the NLRP3 inflammasome, the mechanisms by which these viruses induce IL-1β production are not well understood and remain to be confirmed. The results of this part of the work showed that the replication of cytopathogenic RNA viruses such as vesicular stomatitis virus (VSV) or encephalomyocarditis virus (EMCV) induces lytic cell death leading to an efflux of potassium which triggers activation of the NLRP3 inflammasome. Thus, viruses with a high replication capacity and which have a cytopathic effect are capable of inducing the activation of caspase-1 leading to the production of IL-1β. Conversely, viruses which induce type I IFN response are very poor inducers of the NLRP3 inflammasome.A better understanding of the activation of the inflammasome could help in the development of targeted therapeutic strategies for use in the fight against bacterial and viral infections.Key words: Helicobacter pylori, inflammation, NLRP3 inflammasome, IL-1β, RNA virus
Libros sobre el tema "INTERFERON SIGNATURE"
Buckalew, Nelly A. Pain and Addiction in Older Adults (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0031.
Texto completoCapítulos de libros sobre el tema "INTERFERON SIGNATURE"
Osafo, Newman y Silvio Owusu Dei. "Interferon Signature Analysis". En Reference Module in Biomedical Sciences. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-818731-9.00073-2.
Texto completoAiman, Ayesha, Seemi Farhat Basir y Asimul Islam. "Interferons Horizon Therapeutics". En Interferon - Immune Metabolism [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104718.
Texto completoActas de conferencias sobre el tema "INTERFERON SIGNATURE"
Han, Shuhong, Haoyang Zhuang, Pui Lee, Mingjia Li, Peter Nigrovic y Westley H. Reeves. "186 NRF2 regulation of the interferon signature in lupus macrophages". En 13th International Congress on Systemic Lupus Erythematosus (LUPUS 2019), San Francisco, California, USA, April 5–8, 2019, Abstract Presentations. Lupus Foundation of America, 2019. http://dx.doi.org/10.1136/lupus-2019-lsm.186.
Texto completoMendoza, FA, S. Piera-Velazquez, P. Wermuth, S. Addya, C. Feghali-Bostwick y SA Jimenez. "OP0096 Interferon signature in systemic sclerosis lung microvascular endothelial cells". En Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3739.
Texto completoRönnblom, L. "SP0174 The value of type i interferon signature to stratify patients". En Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.7782.
Texto completoYun, J. H., S. Lee, R. Chase, M. M. Parker, A. Saferali, M. Seo, P. Castaldi y C. P. Hersh. "Interferon-Inducible Blood Gene Expression Signature in COPD Patients with CT Airway Disease Phenotypes". En American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4052.
Texto completoTesser, Alessandra, Gian Marco Moneta, Antonella Insalaco, Rebecca Nicolai, Claudia Bracaglia, Valentina Moressa, Serena Pastore et al. "AB1062 INTER-LABORATORY COMPARISON OF TYPE I INTERFERON SIGNATURE ANALYSES: PAVING THE WAY TO SHARE RECOMMENDATIONS." En Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.7041.
Texto completoYun, J. H., S. Lee, R. Chase, A. Saferali, J. Morrow, R. P. Bowler, P. Castaldi y C. P. Hersh. "An Interferon Inducible Signature of Airway Disease from Gene Expression Profiling of Peripheral Blood from COPDGene". En American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4467.
Texto completoLambers, W., J. Westra, B. Doornbos, MF Jonkman, H. Bootsma y K. de Leeuw. "PS1:5 Interferon signature is increased in incomplete sle and correlates with mxa and ip-10 levels". En 11th European Lupus Meeting, Düsseldorf, Germany, 21–24 March 2018, Abstract presentations. Lupus Foundation of America, 2018. http://dx.doi.org/10.1136/lupus-2018-abstract.54.
Texto completoSikder, Rahmat K., Wafik S. El-Deiry y Philip H. Abbosh. "Abstract 405: PBRM1 re-introduction inPBRM1-mutant kidney cancer cell lines drives an Interferon-γ expression signature". En Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-405.
Texto completoHubbard, Erika, David S. Pisetsky y Peter Lipsky. "1707 Anti-RNP antibodies are associated with the interferon gene signature but not complement activation in SLE". En LUPUS 21ST CENTURY 2021 CONFERENCE, Abstracts of the Fifth Biannual Scientific Meeting of the North and South American and Caribbean Lupus Community, Tucson, Arizona, USA – September 22–25, 2021. Lupus Foundation of America, 2021. http://dx.doi.org/10.1136/lupus-2021-lupus21century.102.
Texto completoVlachogiannis, NI, V.-K. Bournia, A. Nezos, PF Christopoulos, M. Patsouras, PG Vlachoyiannopoulos, CP Mavragani y PP Sfikakis. "THU0028 Type i interferon signature in the peripheral blood and CXCL4 plasma levels in patients with systemic sclerosis". En Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.4066.
Texto completoInformes sobre el tema "INTERFERON SIGNATURE"
Shpigel, Nahum, Raul Barletta, Ilan Rosenshine y Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, enero de 2004. http://dx.doi.org/10.32747/2004.7696510.bard.
Texto completoFicht, Thomas, Gary Splitter, Menachem Banai y Menachem Davidson. Characterization of B. Melinensis REV 1 Attenuated Mutants. United States Department of Agriculture, diciembre de 2000. http://dx.doi.org/10.32747/2000.7580667.bard.
Texto completo