Artículos de revistas: "Integration"

1

Ziegler, Katja. "Integrating Integration?" European Journal of Migration and Law 7, n.º 2 (2005): 119–22. http://dx.doi.org/10.1163/1571816054762223.

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2

Lovelace, Christopher T. y Sarah Partan. "Integrating sensory integration". Trends in Cognitive Sciences 5, n.º 2 (febrero de 2001): 48–49. http://dx.doi.org/10.1016/s1364-6613(00)01589-8.

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3

Scholkmann, Antonia, Nikolaj Stegeager y Richard K. Miller. "Integrating the Integration". Journal of Problem Based Learning in Higher Education 11, n.º 1 (17 de mayo de 2023): 98–123. http://dx.doi.org/10.54337/ojs.jpblhe.v11i1.7371.

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This paper provides a conceptual elaboration of the role of Problem-based Learning (PBL) in the integration of social sciences and humanities (SSH) with science, technology, engineering, and mathematics (STEM), and an analysis of the challenges this brings about. SSH-STEM integration is an endeavor that is timely, relevant, and urgent given the insufficient answers that higher education provides to the challenges social science and (especially) humanity faces. PBL can be argued as a pedagogical model to naturally cater to this demand. Based on two cases of integrated study programs from Aalborg University, Denmark, we analyze and discuss challenges and potential pitfalls in integrating SSH and STEM. As a result, we pinpoint learnings that can serve as timely guides in future iterations of problem-based, inter- and transdisciplinary endeavors in higher education.

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4

Nakai, Hiroyuki, Xiaolin Wu, Sally Fuess, Theresa A. Storm, David Munroe, Eugenio Montini, Shawn M. Burgess, Markus Grompe y Mark A. Kay. "Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver". Journal of Virology 79, n.º 6 (15 de marzo de 2005): 3606–14. http://dx.doi.org/10.1128/jvi.79.6.3606-3614.2005.

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ABSTRACT Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the risk of rAAV integration because integration occurs preferentially in genes and accompanies chromosomal deletions, which may lead to loss-of-function insertional mutagenesis. Here, by analyzing 347 rAAV integrations in mice, we elucidate novel features of rAAV integration: the presence of hot spots for integration and a strong preference for integrating near gene regulatory sequences. The most prominent hot spot was a harmless chromosomal niche in the rRNA gene repeats, whereas nearly half of the integrations landed near transcription start sites or CpG islands, suggesting the possibility of activating flanking cellular disease genes by vector integration, similar to retroviral gain-of-function insertional mutagenesis. Possible cancer-related genes were hit by rAAV integration at a frequency of 3.5%. In addition, the information about chromosomal changes at 218 integration sites and 602 breakpoints of vector genomes have provided a clue to how vector terminal repeats and host chromosomal DNA are joined in the integration process. Thus, the present study provides new insights into the risk of rAAV-mediated insertional mutagenesis and the mechanisms of rAAV integration.

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5

Folk, Charles L. "Integrating Information on Information Integration". Contemporary Psychology: A Journal of Reviews 43, n.º 10 (octubre de 1998): 672–73. http://dx.doi.org/10.1037/001792.

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6

Huo, Baofeng y Mengqiu Guo. "How Does an Aerotropolis Integrate? A Case from Zhengzhou Airport Economy Zone". Logistics 5, n.º 2 (4 de mayo de 2021): 26. http://dx.doi.org/10.3390/logistics5020026.

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As the modern aviation-oriented business model (aerotropolis), the Airport Economy Zone (AEZ) accumulates capital, technology, workforce, and other production factors. The AEZ always has a large number of infrastructure investments. Still, it has not yet achieved the expected effect in integrating and driving other regional resource endowments in the short term in China. Therefore, governments and AEZ organizations must utilize these investments and create values. This paper demonstrates how the Zhengzhou AEZ (ZAEZ) in China integrates its resources and stakeholders to overcome the remaining issues in its airport stage and gain competitive advantages. We classify three integrations: integrations from contents, including strategic alliance, information sharing, and process coordination; integrations from objectives, including internal integration and external integration; and integrations from objects, including integrating stakeholder, financial resource, and material resource. This paper presents the value creation and competitive advantages of the economy zone from the analysis of different integrations.

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7

Daniels, Peter W., Anuradha Mukherjee, Alastair SH Goldman y Bin Hu. "A set of novel CRISPR-based integrative vectors for Saccharomyces cerevisiae". Wellcome Open Research 3 (15 de junio de 2018): 72. http://dx.doi.org/10.12688/wellcomeopenres.14642.1.

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Integrating a desired DNA sequence into yeast genomes is a widely-used genetic manipulation in the budding yeast Saccharomyces cerevisiae. The conventional integration method is to use an integrative plasmid such as pRS or YIplac series as the target DNA carrier. The nature of this method risks multiple integrations of the target DNA and the potential loss of integrated DNA during cell proliferation. In this study, we developed a novel yeast integration strategy based on the widely used CRISPR-Cas9 system and created a set of plasmids for this purpose. In this system, a plasmid bearing Cas9 and gRNA expression cassettes will induce a double-strand break (DSB) inside a biosynthesis gene such as Met15 or Lys2. Repair of the DSB will be mediated by another plasmid bearing upstream and downstream sequences of the DSB and an integration sequence in between. As a result of this repair the sequence is integrated into genome by replacing the biosynthesis gene, the disruption of which leads to a new auxotrophic genotype. The newly-generated auxotroph can serve as a traceable marker for the integration. In this study, we demonstrated that a DNA fragment up to 6.3 kb can be efficiently integrated into the Met15 or Lys2 locus using this system. This novel integration strategy can be applied to various yeasts, including natural yeast isolated from wild environments or different yeast species such as Candida albicans.

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8

Daniels, Peter W., Anuradha Mukherjee, Alastair SH Goldman y Bin Hu. "A set of novel CRISPR-based integrative vectors for Saccharomyces cerevisiae". Wellcome Open Research 3 (26 de julio de 2018): 72. http://dx.doi.org/10.12688/wellcomeopenres.14642.2.

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Integrating a desired DNA sequence into the yeast genomes is a widely-used genetic manipulation in the budding yeast Saccharomyces cerevisiae. The conventional integration method is to use an integrative plasmid such as pRS or YIplac series as the target DNA carrier. The nature of this method risks multiple integrations of the target DNA and the potential loss of integrated DNA during cell proliferation. In this study, we developed a novel yeast integration strategy based on the widely used CRISPR-Cas9 system and created a set of plasmids for this purpose. In this system, a plasmid bearing Cas9 and gRNA expression cassettes will induce a double-strand break (DSB) inside a biosynthesis gene such as Met15 or Lys2. Repair of the DSB will be mediated by another plasmid bearing upstream and downstream sequences of the DSB and an integration sequence in between. As a result of this repair the sequence is integrated into genome by replacing the biosynthesis gene, the disruption of which leads to a new auxotrophic genotype. The newly-generated auxotroph can serve as a traceable marker for the integration. In this study, we demonstrated that a DNA fragment up to 6.3 kb can be efficiently integrated into the Met15 or Lys2 locus using this system. This novel integration strategy can be applied to various yeasts, including natural yeast isolated from wild environments or different yeast species such as Candida albicans.

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9

Cotton, Sian, Stefanie Stevenson y Christina Luberto. "21B. A Horizontal Integration Business Model for Integrative Medicine: Sustainability through Integration". Global Advances in Health and Medicine 2, n.º 1_suppl (enero de 2013): gahmj.2013.097C. http://dx.doi.org/10.7453/gahmj.2013.097cp.s21b.

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10

Goodman, Sara Wallace. "Integration Requirements for Integration's Sake? Identifying, Categorising and Comparing Civic Integration Policies". Journal of Ethnic and Migration Studies 36, n.º 5 (mayo de 2010): 753–72. http://dx.doi.org/10.1080/13691831003764300.

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11

Chang, Liang-Wey y James F. Hamilton. "A Sequential Integration Method". Journal of Dynamic Systems, Measurement, and Control 110, n.º 4 (1 de diciembre de 1988): 382–88. http://dx.doi.org/10.1115/1.3152700.

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This paper presents a method for simulating systems with two inertially coupled motions, i.e., a slow motion and a fast motion. The equations of motion are separated into two sets of coupled nonlinear ordinary differential equations. For each time step, the two sets of equations are integrated sequentially rather than simultaneously. Explicit integration methods are used for integrating the slow motion since the stability of the integration is not a problem and the explicit methods are very convenient for nonlinear equations. For the fast motion, the equations are linear and the implicit integrations can be used with guaranteed stability. The size of time step only needs to be chosen to provide accuracy of the solution for the modes that are excited. The interaction between the two types of motion must be treated such that secular terms do not appear due to the sequential integration method. A lumped model of a flexible pendulum will be presented in this paper to illustrate the application of the method. Numerical results for both simultaneous and sequential integration are presented for comparison.

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12

Rossi Mori, Angelo, Valentina Albano y Jordi Piera Jimenez. "Badalona Story: integrating the integration initiatives". International Journal of Integrated Care 17, n.º 5 (17 de octubre de 2017): 315. http://dx.doi.org/10.5334/ijic.3632.

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13

ZHEN, YI, LIU ZHAO y ZHANYING YANG. "INTEGRATING SUPER-LIOUVILLE SYSTEM WITHOUT INTEGRATION". Modern Physics Letters A 15, n.º 09 (21 de marzo de 2000): 617–28. http://dx.doi.org/10.1142/s0217732300000621.

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Explicit solutions of super-Liouville equation are obtained by the use of a super-extension of the so-called Drinfeld–Sokolov construction. Such solutions can be proved to be local and super-periodic using earlier results of Toppan on exchange algebras based on super-Drinfeld–Sokolov linear systems and of Babelon et al. on the proof of locality and periodicity of ordinary Toda field theories.

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14

L'Abate, Luciano y Tamar Harel. "Integrating Too Much Writing About Integration". Contemporary Psychology: A Journal of Reviews 33, n.º 7 (julio de 1988): 608–10. http://dx.doi.org/10.1037/030481.

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15

Shofwan, Arif Muzayin Shofwan. "INTEGRASI KEILMUAN ISLAM HOLISTIK-INTEGRATIF PERGURUAN TINGGI DI INDONESIA". AL-AUFA: JURNAL PENDIDIKAN DAN KAJIAN KEISLAMAN 6, n.º 01 (22 de junio de 2024): 10–22. http://dx.doi.org/10.32665/alaufa.v6i01.2718.

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There are various ways of integrating holistic-integrative Islamic scholarship in the era of postmodernism such as in Indonesia today. This qualitative descriptive writing with a literature study aims to discuss the holistic-integrative integration of Islamic knowledge in higher education in Indonesia. The data analysis technique uses content analysis by sorting data according to the research objectives and problems. This research found the following two things. First, in essence, the integration of Islamic scholarship from holistic-integrative postmodernism-era thinkers is a criticism of the normative-theological Islamic scientific paradigm of the traditionalism era as well as a criticism of the empirical-sociological Islamic paradigm of the modernism era. Second, the essence of the integration of Islamic science in the postmodern era of religious universities in Indonesia is to end the dichotomy of science and religious science for scientific construction in the future. Several Islamic universities in Indonesia have carried out scientific integration, including UIN Syarif Hidayatullah Jakarta with the concept of Reintegration of Sciences in Islam, UIN Sunan Kalijaga Yogyakarta with the concept of Integration-Interconnection using the Spider Web metaphor, UIN Maulana Malik Ibrahim Malang with the concept of Integration of Science in Islam with the Tree of Knowledge metaphor, UIN Sunan Gunung Djati Bandung with the concept of Wahyu Guiding Knowledge with the wheel metaphor, UIN Alauddin Makasar with the concept of Integration and Interconnection of Science and Religious Knowledge with the metaphor of the Tree of Science Cells, and others.

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16

Arapova, E. "“Integration of Integrations” and Prospects OF BRICS+". World Economy and International Relations 63, n.º 4 (abril de 2019): 5–13. http://dx.doi.org/10.20542/0131-2227-2019-63-4-5-13.

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17

Jørgensen, Lotte, Anna Alwerud, Ingegerd Rabow, Salam Baker Shanawa y Lars Bjørnshauge. "Electronic information resources: integration - integration - integration". Serials: The Journal for the Serials Community 16, n.º 3 (1 de noviembre de 2003): 313–17. http://dx.doi.org/10.1629/16313.

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18

Masol, M. "Integration? Integration. Integration… Integration! (Polycentric Integration of the Content of General Art Education)". Art and education, n.º 1 (2020): 20–27. http://dx.doi.org/10.32405/2308-8885-2020-1-20-27.

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19

Grötsch, Florian y Annette Schnabel. "INTEGRATION – WHAT INTEGRATION?" European Societies 14, n.º 4 (septiembre de 2012): 586–610. http://dx.doi.org/10.1080/14616696.2012.709532.

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20

Wang, Zehua, Xiqian Ye, Yuenan Zhou, Xiaotong Wu, Rongmin Hu, Jiachen Zhu, Ting Chen et al. "Bracoviruses recruit host integrases for their integration into caterpillar’s genome". PLOS Genetics 17, n.º 9 (7 de septiembre de 2021): e1009751. http://dx.doi.org/10.1371/journal.pgen.1009751.

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Some DNA viruses infect host animals usually by integrating their DNAs into the host genome. However, the mechanisms for integration remain largely unknown. Here, we find that Cotesia vestalis bracovirus (CvBV), a polydnavirus of the parasitic wasp C. vestalis (Haliday), integrates its DNA circles into host Plutella xylostella (L.) genome by two distinct strategies, conservatively and randomly, through high-throughput sequencing analysis. We confirmed that the conservatively integrating circles contain an essential “8+5” nucleotides motif which is required for integration. Then we find CvBV circles are integrated into the caterpillar’s genome in three temporal patterns, the early, mid and late stage-integration. We further identify that three CvBV-encoded integrases are responsible for some, but not all of the virus circle integrations, indeed they mainly participate in the processes of early stage-integration. Strikingly, we find two P. xylostella integrases (PxIN1 and PxIN2) are highly induced upon wasp parasitism, and PxIN1 is crucial for integration of some other early-integrated CvBV circles, such as CvBV_04, CvBV_12 and CvBV_24, while PxIN2 is important for integration of a late-integrated CvBV circle, CvBV_21. Our data uncover a novel mechanism in which CvBV integrates into the infected host genome, not only by utilizing its own integrases, but also by recruiting host enzymes. These findings will strongly deepen our understanding of how bracoviruses regulate and integrate into their hosts.

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21

Bailey, Allan L., Grace Moe y Joy Myskiw. "The WestView Primary Care Network in the First Six Months: Defragmenting the System". Healthcare Management Forum 20, n.º 2 (julio de 2007): 34–37. http://dx.doi.org/10.1016/s0840-4704(10)60513-3.

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The objective of this article is to describe the integration of local primary care services through the development of a primary care network in Alberta. WestView Primary Care Network (WPCN) has the vision of integrating primary care teams into the health system. As a result, WPCN has incorporated integrative primary care teams into its clinical programs. Through its strategy of “defragmentation,” WPCN is accomplishing the beginnings of service integration in the local health care context.

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22

Gabriel, Richard, Anna Paruzynski, Ralph Eckenberg, Cynthia C. Bartholomae, Ali Nowrouzi, Wei Wang, Kerstin Schwarzwaelder et al. "Comprehensive and Unbiased Integration Site Analysis in Clinical Gene Therapy." Blood 112, n.º 11 (16 de noviembre de 2008): 2351. http://dx.doi.org/10.1182/blood.v112.11.2351.2351.

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Abstract Retroviral vectors are commonly used gene delivery tools in clinical gene therapy providing stable integration and continuous gene expression of the transgene in the treated host cell. However, integration of the reverse transcribed vector DNA into the host genome is, by itself, a mutagenic eventthat may directly contribute to severe adverse events. The latter has dramatically been obbserved in individual cases in several, otherwise successful, gene therapy trials. Thus, a comprehensive analysis of the existing integration site pool in a transduced sample is indispensable to identify potential in vivo selection of affected cell clones and uncontrolled vector-induced cell proliferation. To date, there are several methods available to study the integration site distribution of retroviral vectors or other integrating elements as transposons. Each of these techniques makes use of restriction enzymes to digest the genomic DNA. To reveal particular vector integrations, a recognition motif of the used restriction enzyme has to be located in an appropriate distance to the integration locus in the host genome. Therefore, the genomic distribution of the recognition sequences directly impact the outcome of restriction enzyme dependent integration site analysis. We here report a validated genomic accessibility model which precisely determines the fraction of the human genome that can be analyzed with one reaction set up (i.e. restriction enzyme used). For our modeling, we used the clinically relevant linear amplification mediated PCR (LAM-PCR) as integration site analysis method of choice and the commonly used frequently cutting restriction enzymes (‘four-cutters’). We show that the most frequent four cutter motif (AATT) gives access to 54.5% of all possible integrations in the human genome, whereas the rarest distributed motif (CGCG) only identifies 2.9%. This restriction bias can be minimized by analyzing the same sample with different enzymes. A combination of the 5 most potent four cutter restriction enzymes gives access to 88.7% of the analyzable genome. Furthermore, we established an unbiased, non-restrictive integration site analysis technique based on (nr) LAM-PCR. Direct ligation of a single-stranded DNA sequence to the linear PCR product evades the need for restriction enzymes to recover integration sites. While standard LAM-PCR was done repeatedly with 3 different enzymes to detect integration sites present in lentivirally transduced single cell clones, nrLAM-PCR detected all integrations in these clones in one single reaction setup. This newly developed method comprehensively recovers genomic locations of integrating elements regardless of a restriction enzyme introduced bias. Our data show that the recovery rate of integration sites present in a transduced sample strongly depends on the restriction enzyme(s) used. However, we demonstrate that the genomic accessibility of viral integration sites indeed can be determined and minimized a priori, and that a non restrictive LAM-PCR approach circumvents the existing limitations. Analysis of the clonal inventory by these methods will allow determining the pharmacodynamics of insertional vectors with unprecedented precision, facilitating development and clinical testing of insertional vector systems.

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23

Pantin, Vladimir I. "The Ideological Foundations of Eurasian Economic Integration". Vestnik RUDN. International Relations 22, n.º 1 (30 de marzo de 2022): 17–29. http://dx.doi.org/10.22363/2313-0660-2022-22-1-17-29.

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The article analyzes the significance of Eurasian ideology for modern economic integration, the reasons for its limited use in the Eurasian Economic Union (EAEU), and the possibilities and prospects of adapting Eurasianism for the purposes of economic development and integration. Many international economic integration associations (e.g., the EU, USMCA, ASEAN) have a common or similar ideological and value-based foundation, which ensures stronger integration. The EAEU was initially established without a common, integrating ideological basis, although the first president of Kazakhstan, Nursultan Nazarbayev, suggested using Eurasianism as the ideology of integration. Sergey Glazyev also wrote about the importance of integrative ideology for the development of the EAEU. However, these attempts to introduce Eurasian ideology for a stronger integration were not supported by the rest of the EAEU countries. This was largely because most EAEU members, including Russia, were driven by short-term economic interests, forgetting about more important long-term, strategic goals. Moreover, there are important ideological divisions in society and in the political elites of Russia, Belarus, Kazakhstan, Armenia, and Kyrgyzstan - primarily the division between adherents of the ideology and practices of Western liberalism, oriented toward EU integration, and supporters of an ideology close to Eurasianism and defense of traditional values, oriented toward the development of integration in the Eurasian space. The reproduction of such divisions in the EAEU countries, as well as the absence or weak development of an integrative ideology, largely determines the inconsistent and not always effective integration in the EAEU. Eurasianism can become an integrative ideology, which, if developed and adapted to modern realities, can ensure a stronger economic integration. This requires overcoming illusions about the possibility of integration of Russia and other post-Soviet countries into the EU, pursuing an active information policy in the Eurasian countries, showing the commonality of geopolitical and economic interests of EAEU countries and the opposition of these interests to those of the USA. Eurasianism can effectively counter the threat of ethnic nationalism in the EAEU countries by emphasizing Eurasian integration as a necessary condition for preserving the sovereignty of Eurasian countries, their traditional values, and the combination of tradition and innovation.

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24

Wu, Cen, Fei Zhou, Jie Ren, Xiaoxi Li, Yu Jiang y Shuangge Ma. "A Selective Review of Multi-Level Omics Data Integration Using Variable Selection". High-Throughput 8, n.º 1 (18 de enero de 2019): 4. http://dx.doi.org/10.3390/ht8010004.

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High-throughput technologies have been used to generate a large amount of omics data. In the past, single-level analysis has been extensively conducted where the omics measurements at different levels, including mRNA, microRNA, CNV and DNA methylation, are analyzed separately. As the molecular complexity of disease etiology exists at all different levels, integrative analysis offers an effective way to borrow strength across multi-level omics data and can be more powerful than single level analysis. In this article, we focus on reviewing existing multi-omics integration studies by paying special attention to variable selection methods. We first summarize published reviews on integrating multi-level omics data. Next, after a brief overview on variable selection methods, we review existing supervised, semi-supervised and unsupervised integrative analyses within parallel and hierarchical integration studies, respectively. The strength and limitations of the methods are discussed in detail. No existing integration method can dominate the rest. The computation aspects are also investigated. The review concludes with possible limitations and future directions for multi-level omics data integration.

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25

Protsenko, E. G. "Conceptual frameworks of integration processes in education". Vestnik of Samara University. History, pedagogics, philology 30, n.º 1 (22 de abril de 2024): 71–76. http://dx.doi.org/10.18287/2542-0445-2024-30-1-71-76.

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The relevance of the topic is connected with the urgent need in modern socio-political realities to use integrative technological tools in solving educational problems. According to the message of the President of the Russian Federation to the Federal Assembly on February 21, 2023, “a synthesis of all the best that was in the Soviet education system and the experience of recent decades is necessary”. Higher education teachers have been given serious goals to develop effective practices for integrating new regions of the Russian Federation into the cultural and educational space of Russia. Integration is the process and result of the formation of integrity, which plays a priority role in relation to its parts. The emergence of integration is closely related to the need to satisfy the fundamental human need to inherit the experience of previous generations, and subsequently transfer it, which is the mechanism of pedagogical activity: the integration of the experience of generations and the integration of pedagogical and production activities. In the article, the author examines the definition of the main research term; relies on the classification of sources for studying integration processes in pedagogy proposed by Professor N.K. Chapaev; the analysis of modern integrative pedagogical concepts is carried out. In these rapidly developing times, we need specialists who are open to interaction and ready to integrate professionals from seemingly completely different areas into their specific activities: integration becomes the basis for the development of the educational sphere.

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26

Williames, L. D. y C. R. Erdie-Lalena. "Complementary, Holistic, and Integrative Medicine: Sensory Integration". Pediatrics in Review 30, n.º 12 (1 de diciembre de 2009): e91-e93. http://dx.doi.org/10.1542/pir.30-12-e91.

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27

Wilding, Helen. "Integrating Care: From Horizontal to Vertical Integration". Journal of Integrated Care 18, n.º 3 (junio de 2010): 15–20. http://dx.doi.org/10.5042/jic.2010.0244.

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28

Eisenberg, Nancy. "Integrative Processes and Socialization: A Difficult Integration". Contemporary Psychology: A Journal of Reviews 35, n.º 1 (enero de 1990): 56–57. http://dx.doi.org/10.1037/028172.

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29

Allen, H. A. y G. W. Humphreys. "Orientation integration is intact in integrative agnosia". Journal of Vision 5, n.º 8 (16 de marzo de 2010): 291. http://dx.doi.org/10.1167/5.8.291.

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30

Browning, Tyson R. "MULTI-TEAM INTEGRATION: INTERDEPENDENCE AND INTEGRATIVE MECHANISMS". INCOSE International Symposium 6, n.º 1 (julio de 1996): 801–8. http://dx.doi.org/10.1002/j.2334-5837.1996.tb02087.x.

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31

Johnson, Heather L., Kimber L. Court, Margriet H. Roersma y David T. Kinnaman. "Integration as Integration: Tolerance of Ambiguity and the Integrative Process at the Undergraduate Level". Journal of Psychology and Theology 23, n.º 4 (diciembre de 1995): 271–76. http://dx.doi.org/10.1177/009164719502300407.

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Intolerance of ambiguity is described as an impediment to effective integration. A bidirectional relationship between personal wholeness and the integrative process is outlined, and implications are drawn for the teaching of integration at the undergraduate level. These recommendations are illustrated by vignettes from the authors’ undergraduate experiences.

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32

Chen, Xun, Jason Kost y Dawei Li. "Comprehensive comparative analysis of methods and software for identifying viral integrations". Briefings in Bioinformatics 20, n.º 6 (8 de agosto de 2018): 2088–97. http://dx.doi.org/10.1093/bib/bby070.

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Abstract Many viruses are capable of integrating in the human genome, particularly viruses involved in tumorigenesis. Viral integrations can be considered genetic markers for discovering virus-caused cancers and inferring cancer cell development. Next-generation sequencing (NGS) technologies have been widely used to screen for viral integrations in cancer genomes, and a number of bioinformatics tools have been developed to detect viral integrations using NGS data. However, there has been no systematic comparison of the methods or software. In this study, we performed a comprehensive comparative analysis of the designs, performance, functionality and limitations among the existing methods and software for detecting viral integrations. We further compared the sensitivity, precision and runtime of integration detection of four representative tools. Our analyses showed that each of the existing software had its own merits; however, none of them were sufficient for parallel or accurate virome-wide detection. After carefully evaluating the limitations shared by the existing methods, we proposed strategies and directions for developing virome-wide integration detection.

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33

Van, Hung Tran y Denis Ushakov. "Analysis of economic imbalances under the conditions of regional agrarian markets’ integration". E3S Web of Conferences 175 (2020): 13034. http://dx.doi.org/10.1051/e3sconf/202017513034.

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At the current stage of economic globalization, the leading factor, among several others, is the intensification of regional economic integration. The share of countries participating in this regional integration covers about 60% of the world GDP. In this article we apply statistical analysis along with several theoretical approaches to ground and explain the objectivity of convergence and divergence of the national economic systems within the frameworks of integrational unions. We also analyze the trend of economic space asynchronization inside integrations along with the national and regional factors of ongoing regionalization. Our conclusions concern primarily the supranational instruments of participating economies’levelling.

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Rajaby, Ramesh, Yi Zhou, Yifan Meng, Xi Zeng, Guoliang Li, Peng Wu y Wing-Kin Sung. "SurVirus: a repeat-aware virus integration caller". Nucleic Acids Research 49, n.º 6 (14 de enero de 2021): e33-e33. http://dx.doi.org/10.1093/nar/gkaa1237.

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Abstract A significant portion of human cancers are due to viruses integrating into human genomes. Therefore, accurately predicting virus integrations can help uncover the mechanisms that lead to many devastating diseases. Virus integrations can be called by analysing second generation high-throughput sequencing datasets. Unfortunately, existing methods fail to report a significant portion of integrations, while predicting a large number of false positives. We observe that the inaccuracy is caused by incorrect alignment of reads in repetitive regions. False alignments create false positives, while missing alignments create false negatives. This paper proposes SurVirus, an improved virus integration caller that corrects the alignment of reads which are crucial for the discovery of integrations. We use publicly available datasets to show that existing methods predict hundreds of thousands of false positives; SurVirus, on the other hand, is significantly more precise while it also detects many novel integrations previously missed by other tools, most of which are in repetitive regions. We validate a subset of these novel integrations, and find that the majority are correct. Using SurVirus, we find that HPV and HBV integrations are enriched in LINE and Satellite regions which had been overlooked, as well as discover recurrent HBV and HPV breakpoints in human genome-virus fusion transcripts.

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Azmi, Muhamad, Muhammad Akmansyah y Amiruddin. "Pendekatan dalam Integrasi Kurikulum Pondok Pesantren dan Madrasah: Studi di Pondok Pesantren Al-Hikmah Bandar Lampung". Bustanul Ulum Journal of Islamic Education 1, n.º 2 (5 de febrero de 2024): 212–23. http://dx.doi.org/10.62448/bujie.v1i2.34.

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Curriculum integration in islamic education refers to involves integrating the concepts and content of religius learning and general learning. This study outlines the integration of salaf Islamic boarding school education with the madrasah curriculum at Pondok Pesantren Al-Hikmah Bandar Lampung. This type of research is a type of qualitative research and data collection technique used snowball sampling for interviews, accompanied by observation and documentation. The data were analyzed using integrative and interactive techniques. This study found that the Islamic integrated curriculum in Pondok Pesantren Al-Hikmah Bandar Lampung was applied by combining the national curriculum with salaf islamic boarding school (pesantren salaf) education. The integration of madrasa and salaf Islamic boarding school curriculum is to open ourselves to the progress of the times where students are equipped with religious knowledge and general science. Implementation of curriculum integration with a social-religious approach by inserting religious moderation values in learning.

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Cunha, Miguel Pina e., Rebecca Bednarek y Wendy Smith. "Integrative ambidexterity: one paradoxical mode of learning". Learning Organization 26, n.º 4 (13 de mayo de 2019): 425–37. http://dx.doi.org/10.1108/tlo-02-2019-0038.

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Purpose Organizational ambidexterity brings together the paradoxical tensions between exploration and exploitation. Embracing such paradoxical tensions depends on both separating the poles to appreciate their distinct elements and integrating them to appreciate their synergies. This paper explores integrative ambidexterity that focuses on the synergies between exploration and exploitation and theorizes these as a single, paradoxical mode of learning. Design/methodology/approach The authors provide conceptual commentary that aims to expand the attention within the ambidexterity literature from emphasizing separation to further accommodating integration. Findings The authors outline that attention to separating exploration and exploitation needs to be complemented with a focus on integration, hence, the notion of integrative ambidexterity. Research limitations/implications The authors surface three processes that advance integrative ambidexterity – novelty via memory; agility via focus; and the potential for improvisation. Together, these dynamics enable organizations to achieve an alternative approach to learning and adaptation. Practical implications Understanding “integrative ambidexterity,” stressing the synergies between exploration and exploitation, extends the understanding of the nature and approaches to creating learning organizations. The authors three practices offer a potential blueprint to do so. Originality/value Previous scholarship emphasized how leaders can separate exploration and exploitation by allocating these learning modes to distinct organizational units or addressing them in different time horizons. However, extant authors have less insight about the integration and synergies between exploration and exploitation, and the organizational factors that advance such integration.

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Kumar Ale, Narendar. "Integrating Continuous Integration / Continuous Deployment (CI/CD) with Test Automation: Enhancing Software Development Efficiency". International Journal of Science and Research (IJSR) 11, n.º 1 (5 de enero de 2022): 1636–38. http://dx.doi.org/10.21275/sr24627045933.

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López de Maturana, Evangelina, Lola Alonso, Pablo Alarcón, Isabel Adoración Martín-Antoniano, Silvia Pineda, Lucas Piorno, M. Luz Calle y Núria Malats. "Challenges in the Integration of Omics and Non-Omics Data". Genes 10, n.º 3 (20 de marzo de 2019): 238. http://dx.doi.org/10.3390/genes10030238.

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Omics data integration is already a reality. However, few omics-based algorithms show enough predictive ability to be implemented into clinics or public health domains. Clinical/epidemiological data tend to explain most of the variation of health-related traits, and its joint modeling with omics data is crucial to increase the algorithm’s predictive ability. Only a small number of published studies performed a “real” integration of omics and non-omics (OnO) data, mainly to predict cancer outcomes. Challenges in OnO data integration regard the nature and heterogeneity of non-omics data, the possibility of integrating large-scale non-omics data with high-throughput omics data, the relationship between OnO data (i.e., ascertainment bias), the presence of interactions, the fairness of the models, and the presence of subphenotypes. These challenges demand the development and application of new analysis strategies to integrate OnO data. In this contribution we discuss different attempts of OnO data integration in clinical and epidemiological studies. Most of the reviewed papers considered only one type of omics data set, mainly RNA expression data. All selected papers incorporated non-omics data in a low-dimensionality fashion. The integrative strategies used in the identified papers adopted three modeling methods: Independent, conditional, and joint modeling. This review presents, discusses, and proposes integrative analytical strategies towards OnO data integration.

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Robinson, Jessica L., Karl Manrodt, Monique Lynn Murfield, Christopher A. Boone y Paige Rutner. "Achieving integration". International Journal of Logistics Management 29, n.º 4 (12 de noviembre de 2018): 1306–24. http://dx.doi.org/10.1108/ijlm-08-2017-0213.

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PurposeThe purpose of this paper is to propose and test a dual pathway model whereby addressing the question, “What are the effects of supply chain orientation and organizational identification on internal integration and supplier integration?”.Design/methodology/approachA survey design was performed to collect data from supply chain professionals regarding their organization’s supply chain orientation (SCO), organizational identification (OI) and achieved states of both internal and supplier integration. Partial least squares-structural equation modeling was performed to test the dual mediating pathways.FindingsThe results show that internal integration partially mediates relationships between SCO and supplier integration and for OI and supplier integration. In comparing the mediating effects to test competing theories, the SCO path yields stronger complementary partial mediation. This supports the proposition that SCO and OI mutually exist within an organization and influence achieved integrative behaviors. Additionally, results suggest the behavioral spillover effect exists for an internally integrated organization that has also achieved supplier integration.Originality/valueThis research makes several contributions to extant literature, including finding that SCO contributes to levels of achieved integration. Also, this research theoretically integrates literature on the social dilemma associated with supplier integration and the behavioral spillover effect, suggesting that SCO allows for positive internal integrative behaviors to spillover to integrated suppliers. Finally, this research contributes to research on OI by finding achieved integration is an outcome, which refutes a dominate theory that explains OI facilitates negative behaviors toward external organizations.

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Best, Stephanie. "Facilitating integrated delivery of services across organisational boundaries: Essential enablers to integration". British Journal of Occupational Therapy 80, n.º 5 (17 de marzo de 2017): 302–9. http://dx.doi.org/10.1177/0308022616688019.

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Introduction Integrating services is a key tenet to developing services across the United Kingdom. While many aspects of integration have been explored, how to facilitate integration of services remains unclear. Method An exploratory qualitative study was undertaken in 2015 to explore occupational therapists’ perceptions on integrating service provision across health and social care organisational boundaries. The views of practitioners who had experienced integration were sought on a range of aspects of integrating services. This paper focuses on the facilitators for delivering integration and the essential enablers are identified. Findings Numerous factors were noted to facilitate integration and three essential enablers were highlighted. Leadership, communication and joint education were recognised as playing a central role in integrating services across organisational boundaries; without these three essential enablers, integration is liable to fail. Conclusion Integration is a process rather than an event; continued emphasis will be required on leadership, communication and joint education to progress integration achievements made to date.

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Fischer, Sabine, Janis Kluge y Astrid Sahm. "Souveränität, Subordination, Integration". osteuropa 70, n.º 10-11 (2020): 291. http://dx.doi.org/10.35998/oe-2020-0081.

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Schwabik, Štefan. "Bochner product integration". Mathematica Bohemica 119, n.º 3 (1994): 305–35. http://dx.doi.org/10.21136/mb.1994.126162.

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Hildebrandt, Jens. "Solidarität, Integration, Konflikt". osteuropa 72, n.º 4-5 (2022): 127. http://dx.doi.org/10.35998/oe-2022-0134.

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Nehyba, Jiri, Sanandan Malhotra, Shelby Winans, Thomas H. O'Hare, James Justice y Karen Beemon. "Avian Leukosis Virus Activation of an Antisense RNA Upstream ofTERTin B-Cell Lymphomas". Journal of Virology 90, n.º 20 (10 de agosto de 2016): 9509–17. http://dx.doi.org/10.1128/jvi.01127-16.

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ABSTRACTAvian leukosis virus (ALV) induces tumors by integrating its proviral DNA into the chicken genome and altering the expression of nearby genes via strong promoter and enhancer elements. Viral integration sites that contribute to oncogenesis are selected in tumor cells. Deep-sequencing analysis of B-cell lymphoma DNA confirmed that the telomerase reverse transcriptase (TERT) gene promoter is a common ALV integration target. Twenty-six unique proviral integration sites were mapped between 46 and 3,552 nucleotides (nt) upstream of theTERTtranscription start site, predominantly in the opposite transcriptional orientation toTERT. Transcriptome-sequencing (RNA-seq) analysis of normal bursa revealed a transcribed region upstream ofTERTin the opposite orientation, suggesting theTERTpromoter is bidirectional. This transcript appears to be an uncharacterized antisense RNA. We have previously shown thatTERTexpression is upregulated in tumors with integrations in theTERTpromoter region. We now report that the viral promoter drives the expression of a chimeric transcript containing viral sequences spliced to exons 4 through 7 of this antisense RNA. Clonal expansion of cells with ALV integrations driving overexpression of theTERTantisense RNA suggest it may have a role in tumorigenesis.IMPORTANCEThe data suggest that ALV integrations in the TERT promoter region drive the overexpression of a novel antisense RNA and contribute to the development of lymphomas.

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Abiasen, Jovalson y Gaudelia Reyes. "Computer Simulation Integration in Secondary Physics". International Journal of Asian Education 2, n.º 4 (18 de noviembre de 2021): 480–92. http://dx.doi.org/10.46966/ijae.v2i4.185.

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This paper explored the teaching experiences of physics teachers in integrating computer simulations in their pedagogy to promote a constructivist learning environment. Its objectives are to determine how physics teachers describe computer simulations based on how they are used, how these are embedded in the teaching-learning process, their impact on the teaching-learning process, and the challenges of integrating these into physics teaching. Using the phenomenological design, two themes emerged for the first objectives, which are process-based and system-based. First, the teacher-manipulated with sub-themes of engaging, demonstrating, elaborating, and evaluating, and student-manipulated emerged on how the simulations are used. Second, the impact to teaching generated knowledge-based, skill-based, and value-based learning-based primarily on the three learning domains. Also, respondents emphasized that the integrations of computer simulations are convenience, efficacy, and heterogeneity. Finally, the challenges in the integration process are classified as teacher and school-related. The results showed that teachers are integrating computer simulations differently depending on their resources and the TPACK knowledge.

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Makruf, Imam. "Leadership Model in Integrated Islamic Educational Institutions". Jurnal Pendidikan Islam 6, n.º 2 (27 de diciembre de 2017): 331. http://dx.doi.org/10.14421/jpi.2017.62.331-348.

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Leadership has an important role in the educational institutions. The increasing number of implementation models of integrative Islamic education institutions demand greater competence of the leaders in order to perform their duties effectively. The most complex integrative Islamic educational institution model is developed based on boarding school by integrating formal and nonformal education as well as cross ladder as developed by Al Mukmin Islamic Boarding School (PPIM) Ngruki and modern boarding schools in general. The result of this study shows that the effective leadership model of an integrative Islamic educational institution is a democratic-transformational model. This model needs the institutional leaders to have professional, personal, social, and spiritual competences. The integration of the educational institutions management should be done thoroughly starting from the integration of curriculum management, human resources, infrastructure, financing, public relations and marketing, and other aspects.

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Dobrakov, Ivan. "On integration in Banach spaces, IX. Integration with respect to polymeasures". Czechoslovak Mathematical Journal 38, n.º 4 (1988): 589–601. http://dx.doi.org/10.21136/cmj.1988.102255.

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Dobrakov, Ivan. "On integration in Banach spaces. X: Integration with respect to polymeasures". Czechoslovak Mathematical Journal 38, n.º 4 (1988): 713–25. http://dx.doi.org/10.21136/cmj.1988.102267.

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Dobrakov, Ivan. "On integration in Banach spaces, XI. Integration with respect to polymeasures". Czechoslovak Mathematical Journal 40, n.º 1 (1990): 8–24. http://dx.doi.org/10.21136/cmj.1990.102355.

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50

Dobrakov, Ivan. "On integration in Banach spaces, XII. Integration with respect to polymeasures". Czechoslovak Mathematical Journal 40, n.º 3 (1990): 424–40. http://dx.doi.org/10.21136/cmj.1990.102395.

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