Tesis sobre el tema "Industrie pharmaceutique – Gestion de l'approvisionnement"
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SALEUR, LAURENT. "Gestion integree de la qualite". Strasbourg 1, 1987. http://www.theses.fr/1987STR10757.
Texto completoAit, Mamoun Khadija. "Vehicle rοuting prοblem under uncertainty : case οf pharmaceutical supply chain". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMIR08.
Texto completoThe enhancement of logistics distribution performance and the optimization of transportation have emerged as critical concerns in recent years. The pharmaceutical distribution sector faces significant challenges in route planning and transport network optimization, with uncertainties often leading to delays and losses. The multifaceted challenges encompass the imperative to elevate product quality, reduce costs, minimize total travel distance, and streamline transportation time for effective planning. Within this context, the Vehicle Routing Problem (VRP) stands out as one of the extensively analysed problems in the realms of transportation, distribution, and logistics. Achieving a delicate equilibrium between cost considerations and delivering high-quality pharmaceutical products is a primary objective in pharmaceutical distribution. This research delves into both the Static Vehicle Routing Problem (SVRP) and the Dynamic Vehicle Routing Problem (DVRP). Real-world logistical planning frequently encounters uncertainties at the outset, including uncertain customer demand, delivery quantities, time constraints, and more. This thesis introduces the "temperature condition" as a fundamental constraint in pharmaceutical distribution, representing a source of uncertainty that directly impacts drug quality, thereby influencing logistics distribution and overall supply chain performance. Furthermore, the thesis incorporates uncertainty quantification for modelling uncertain travel times in both recurrent and non-recurrent congestion scenarios. The methodology employed for this purpose is the collocation method, initially validated through Monte Carlo Simulation (MCS). By addressing these multifaceted challenges and uncertainties, this research seeks to contribute to the development of robust strategies in pharmaceutical distribution, ensuring the optimization of routes, reduction of costs, and maintenance of high-quality product standards. The findings of this study offer valuable insights for logistics managers and planners aiming to navigate the complexities of pharmaceutical distribution, fostering efficiency and resilience in the face of uncertainties
Gratias, Ghislaine. "La gestion des réactifs au service de la qualité". Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P007.
Texto completoBrun, Véronique. "Gestion documentaire dans l'industrie pharmaceutique : application aux procédures". Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P092.
Texto completoChouraqui, Fabrice. "Principes de gestion de projet en recherche et développement". Paris 5, 1995. http://www.theses.fr/1995PA05P267.
Texto completoVechembre, Sophie. "Traitement et exploitation des incidents en industrie pharmaceutique". Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P049.
Texto completoFISCHER, DENIS. "Les systemes informatiques de controle et d'execution de la production pharmaceutique". Strasbourg 1, 1994. http://www.theses.fr/1994STR15002.
Texto completoVerdelhan, Cécile de. "Mise en place d'une informatisation dans le flux de matières premières". Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P122.
Texto completoArmand-Laroche, Rosamée. "Management de la qualité totale dans un centre de recherche pharmacologique". Paris 5, 1994. http://www.theses.fr/1994PA05P046.
Texto completoZiedi, Raja. "Stratégies d'approvisionnement dans un contexte d'enchères de bois". Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/26819.
Texto completoMULLER, CHRISTINE. "La gestion des dechets dans l'industrie pharmaceutique de la cee : application a lilly france". Strasbourg 1, 1995. http://www.theses.fr/1995STR15004.
Texto completoRahimi, Ali. "Selection of Wood Supply Contracts to Reduce Cost in the Presence of Risks in Procurement Planning". Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/66765.
Texto completoProcurement activities in the pulp and paper industry account for an important part of the overall supply chain cost. Procurement decision-makers plan for the required wood supply up to one year in advance to guarantee the supply volume for the continuous production process at their mill. Regular, flexible and option contracts with suppliers in different groups are available. Suppliers are grouped based on common characteristics such as forestland ownership. However, during the execution of the plan, sourcing risks affect procurement operations. If risks are not integrated into the procurement planning process, mitigating their impact is likely to be expensive and complicated. Additional expensive ad hoc contracts might be required to compensate for the lack of deliveries. To tackle this problem, the first project of this thesis demonstrates the development of a deterministic mathematical model of procurement operations. The objective of the model is to propose an annual procurement plan to minimize the total cost of procurement operations. The operations are subject to constraints such as the minimum share of supply for each group of suppliers, inventory target levels, demand, woodyard capacity, and chipping process capacity. The decisions are related to the selection of sourcing contracts, woodyards opening, and wood supply flow. In the second project, an evaluation of the procurement plan from the deterministic model from project one is performed by using a Monte Carlo simulation approach. Three different strategies are compared as fixed, flexible, and a mix of both contracts. The simulation approach in this project evaluates the performance of the plan by the expected value and variability of the total cost when the plan is executed during the planning horizon. In the third project, a two-stage stochastic programming approach is used to provide a reliable procurement plan. The objective of the model is to minimize the expected cost of the procurement plan in the presence of different scenarios generated based on sourcing risks. First-stage decisions are the selection of contracts in the first period and the opening of woodyards. Second-stage decisions concern the selection of contracts starting after the first period, flow, inventory, and chipping process production. The case study used in this thesis was inspired by Domtar, which is a pulp and paper company located in Quebec, Canada. The results of three projects in this doctoral dissertation support decision-makers to reduce the human limitation in performing complicated procurement planning. The developed mathematical models provide a basis to evaluate the selected procurement strategy. This task is nearly impossible with current approaches in the company, as the evaluations require the formulation of v sourcing risks. The stochastic programming approach shows better financial results comparing to deterministic planning, with low variability in mitigating the impact of risks.
Savard, Mylène. "Planification stratégique d'un réseau logistique : Cas d'une entreprise forestière au Québec et de ses activités d'approvisionnement". Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28440/28440.pdf.
Texto completoDarmasetiawan, I. Gedé. "Stratégie des entreprises et rôles de l'état dans le processus d'indépendance technologique : le cas du secteur de l'industrie pharmaceutique Indonésienne". Grenoble 2, 1987. http://www.theses.fr/1987GRE21032.
Texto completoThis study concentrated the analyse of the technological dependency in the micro-economic level and its mainly concerned about the partnership and the strategical dimensions of the entreprise. In the term of the partnership was studying the relations of power and strategies which determine the connections between the state, the buyers and the sellers of technologies. For studying the strategical dimensions, this study took into account the variables bounded in internal dimension (internal of enterprise) and external (linked to the environment), as well as the explicite dimension (the strategical decisions making, the technological expertness, the kind of technological transfer) and the implicite (power, strategy and corporate culture). The main objective is to identify the links which etablished between the stage of technological dependency and the concepts of power, strategy and corporate culture in the level of a given industrial sector. The survey results had lead to formulate several remarks : a) there was a various types of strategical behavior of the studying pharmaceutical firms which determine their level in the technological development. This various types was defined from the position more or less dependent toward the foreign capital and the characteristics of used technologies. B) there were the coherent links between the independence stage in strategical decisions making, the impact of sectorial environment and the politic of technological development. In definitive, the dynamic of power exertion in the firms is a explanatory factor of the existance conditons of technological dependancy. C) the necessity of state interventions in favour of a technological development on the more national base
Poissonnier, Hugues. "Proposition d'un cadre d'analyse du contrôle inter-organsationnel fondé sur la chaîne de contrôle : une étude centrée sur la filière THD". Montpellier 2, 2005. http://www.theses.fr/2005MON20164.
Texto completoCharbit, Claire. "Les compétences fondamentales, un outil de gestion ? : application à l'industrie pharmaceutique". Paris 9, 1998. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=1998PA090039.
Texto completoIn the context of the analysis of firms' strategies and performances, core competencies appeared in the early 1990s, in C. K. Prahalad and G. Hamel's publications, as a new way of approaching competitiveness. The first objective of this thesis is to propose a synthetic and operational definition of core competencies. This definition is as follows: core competencies are a combination of knowledge and technologies that enables the company to get a competitive advantage in a whole range of products and services. Core competencies: - enable accessing a large number of markets, unnecessarily related, - enable improving the value of the product for the end-customer, - are difficult to imitate or to acquire for competitors, - are transverse regarding the company's activities. The second objective is to discuss the appropriateness of using core competencies as a management tool, especially in the pharmaceutical industry. Interviews with managers of pharmaceutical companies lead to the identification of the perceived core competencies of these companies. The confrontation of these perceived core competencies and the identification criteria of the definition showed difficulties in understanding the operational and managerial implications of the concept. A synthesis on the applicability of core competencies as a management tool is then given
Beck, Amina. "Choix de projets pharmaceutiques : exemple d'application des méthodes Electre IV et Prométhée III et comparaison avec une méthode multicritère d'aide à la décision, méthode des toiles". Dijon, 1993. http://www.theses.fr/1993DIJOE019.
Texto completoJamen, Robert. "Gestion stratégique de la recherche et développement dans les groupes industriels pharmaceutiques". Dijon, 1993. http://www.theses.fr/1993DIJOE013.
Texto completoThe research and development of a new drug is more and more costly, about 250 millions today. This expensive cost cannot be recouped only by selling new drugs worlwide. Our aim was to build a model of the strategic management of pharmaceutical research and development. The main conclusions follow. 1. Strategic management of research. Pharmaceutical research is based today on the elucidation of biological mechanisms. Close links with fundamental research are therefore a necessity. Speed is a major constraint in research, and pharmaceutical companies must focus on a smaller number of research directions, in order to dispose of a critical mass per therapeutic area. 2. Strategic management of development. Speed and globalization are the two main constraints for drug development. Companies which are not established worldwide must look for strategic alliances in order to compensate for this lack of geographical coverage. 3. Strategic management of the drug portfolio
Godron, Marie-Noe͏̈lle. "Du dossier de fabrication de lot au compte rendu d'exécution des opérations". Paris 5, 1994. http://www.theses.fr/1994PA05P229.
Texto completoGuillet, Karelle. "Hygiène industrielle : maîtrise de l'environnement dans un établissement pharmaceutique". Bordeaux 2, 1999. http://www.theses.fr/1999BOR2P084.
Texto completoBoulay, Laurence. "Mise en place et validation d'un logiciel de gestion de laboratoire". Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P006.
Texto completoNeuville, Jean-Philippe. "Le contrat de confiance : étude des mécanismes de coopération dans le partenariat industriel autour de deux grands constructeurs automobiles européens". Paris, Institut d'études politiques, 1996. http://www.theses.fr/1996IEPP0005.
Texto completoThe industrial partnership is one of the possible forms of the organized action between market and hierarchy. With the tools of the sociological analysis of organizations, an empirical comparison of two partnerships is carried out in the automobile manufacturing sector in europe. Results show that this form of industrial cooperation is characterized, first by a common framework : quality ; second; by a specific regulation mecanism : trust ; finally, by a structure of social exchange in which economic exchange is embedded in : interpersonal networks
Deleska, Florence. "Contribution de la Gestion de Production Assistée par Ordinateur à la mise en œuvre des bonnes pratiques de fabrication". Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P056.
Texto completoLeydet, Fabrice. "Mise en place d'un projet proche infrarouge dans l'industrie pharmaceutique". Bordeaux 2, 1998. http://www.theses.fr/1998BOR2P052.
Texto completoDupuy, Matthieu Dupont Lionel Lamothe Jacques. "Contributions à l'analyse des systèmes industriels et aux problèmes d'ordonnancement à machines parallèles flexibles application aux laboratoires de contrôle qualité en industrie pharmaceutique /". Toulouse : INP Toulouse, 2006. http://ethesis.inp-toulouse.fr/archive/00000204.
Texto completoBassetti, Ann-Laure. "Gestion du changement, gestion de projet : convergence - divergence : cas des risques en conception et mise en place d'une organisation de management de l'environnement". Phd thesis, Paris, ENSAM, 2002. http://tel.archives-ouvertes.fr/tel-00005641.
Texto completoRouquet, Charlotte. "Zone d'atmosphère contrôlée : aspect règlementaire et validation". Paris 5, 2001. http://www.theses.fr/2001PA05P044.
Texto completoRoquebert, Dominique Pierre. "Organisation des hommes et des flux de produits : exemple d'un atelier de production". Bordeaux 2, 1991. http://www.theses.fr/1991BOR2P123.
Texto completoAuger, Maxime. "Bénéfices et exigences de l'optimisation mathématique pour la planification de l'allocation du bois aux usines de produits forestiers". Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27865.
Texto completoSupply planning is a significant challenge for the forest industry, particularly in natural forests characterized by great heterogeneity. Such forests produce raw material suitable for different final products. Thus, developing plans to match supply with demand becomes a complex problem for forest planners. The automatization of the planning approach using an optimization tool allows many important factors to be taken into consideration during planning. In the literature, several theoretical models have been proposed, but it appears that very few of these are currently used by companies. It is assumed that the complexity of the problem, the ever changing nature of the planning environment, and the expertise required to use these models limit their application in industrial context. Nevertheless, the implementation of such tools could bring significant improvements in profits for the forest companies. The aims of the study are threefold : (i) to evaluate the potential for the implementation of mathematical optimization in companies, in particular by identifying the additional resources needed to adopt such an approach, (ii) to estimate the potential gains associated with utilization of optimization model in formulating wood procurement planning in an industrial case, and (iii) to analyze the effect of variation in the information used could have on the plans. An optimization software (LogiLab) developed by the FORAC research consortium was used. The tool allows to maximize the profit generated on the entire supply chain through optimal allocation of raw materials to mills in the network. The model simultaneously considers both harvesting and transportation cost, the heterogeneity of the forest and mill performances. The planning done now in companies visually focuses on lower transportation distance. We adapted LogiLab to a case study involving a Canadian forest products company, to analyze the generated profits, and assess its potential for implementation. To realize the second objective, we studied the planning method of our Partner Company and compared it to the optimization approach that we used for generating the optimal plan. Finally, we adjusted the baseline inventory data using actual data from the measurement to test the effect of the variability of the information used in developing the plans. A higher net profit was generated when using our planning approach in comparison to the plan prepared by the company. This difference is due, in part, to a more efficient allocation of raw materials to the mills. With regards to the second objective, we found several advantages such as a reduction in the time needed to produce a plan. Moreover, even if the cost of implementation is high they are recovered in less than two years by savings in planning time. The gains generated following the optimized plans exceed by several orders of magnitude the initial costs of the system to be set up.
Gautam, Shuva Hari. "Exploring wood procurement system agility to improve the forest products industry’s competitiveness". Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26319.
Texto completoThe significant downfall experienced by the Canadian forest products industry in the past decade has catalyzed the industry into a process of transformation. A concerted effort to maximize economic value from forest resources through innovation in both products and processes is currently underway. This thesis focuses on process innovation of wood procurement systems (WPS). WPS includes upstream processes and actors in the forest products supply chain, responsible for procuring and delivering raw materials from forests to manufacturing mills. The competitiveness of the industry depends on the agility of WPS to deliver the right product to the right customer at the right time. The specific aims of the thesis are to identify opportunities to improve wood procurement system agility, quantify the potential improvement in performance and propose a mechanism to anticipate its long-term impact. Agility is the ability to respond promptly and effectively to unexpected short-term fluctuation in demand. We first identify the capabilities a WPS needs to possess in order to enable agility; we then review the literature in the WPS domain to search for evidence of these capabilities. An opportunity to improve agility of WPS was then identified. It entailed providing managers with flexibility in the choice of silvicultural treatments at the operational level to permit better alignment of supply with the prevailing demand. An experiment was conducted using industry data to quantify the potential benefits associated with the approach. In scenarios where flexibility was permitted, significantly higher profits and demand fulfillment rates were observed. Next, a simulation-optimization system for hierarchical forest management planning was developed to examine the influence of operational level silvicultural flexibility on long-term wood supply. The system was implemented to a forest management unit in Québec in a rolling planning horizon basis for a 100 year horizon. The system demonstrated a capability to measure short and long-term impacts of supply decisions. It will prove to be a useful tool to better integrate forest management practices and supply chain needs.
Kone, Kandana. "La performance de la coordination verticale dans le secteur porcin au Québec". Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27794.
Texto completoThe main objective of this research is to identify performance indicators of vertical coordination, according to the perceived importance of the actors, in an agri-food supply chain. On the basis of the conceptual framework developed by Aramyan et al. (2007), which used four categories of performance indicators: efficiency, flexibility, responsiveness and food quality, this master's thesis focused on a pork supply chain in Quebec, as a case study. The research begins with a literature review on existing performance indicators in the literature on agri-food supply chains. On the basis of this review of the literature, the preliminary conceptual framework resulting from the work of Aramyan et al. (2007) was consolidated by the one developed by Gellynck et al. (2008). This conceptual framework was then assessed in the selected supply chain. The results show that efficiency in terms of cost and profit, flexibility in customer satisfaction, the balance of the chain in the sharing of risks and benefits, and quality (product and process) are the most important performance indicators in this agri-food chain. Keywords: vertical coordination, food chain, indicator, performance, pig.
Laboulbenne, Sophie. "Application aux enregistrements internationaux d'un logiciel de gestion administrative des spécialités pharmaceutiques en France". Bordeaux 2, 1994. http://www.theses.fr/1994BOR2P044.
Texto completoGharbi, Chourouk. "Étude du processus de planification des approvisionnements forestiers au Québec et mesure de sa performance". Master's thesis, Université Laval, 2014. http://hdl.handle.net/20.500.11794/25525.
Texto completoDubois, Philippe. "Exploitation des matières premières lithiques dans des industries du paléolithique moyen en Languedoc oriental". Montpellier 3, 2003. http://www.theses.fr/2003MON30024.
Texto completoHuerre, Thomas. "Prix de marché et contrats de long terme : L’exemple du gaz". Paris 9, 2007. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=2007PA090062.
Texto completoThis thesis is interested in the natural gas price definition in Europe following the process of liberalisation: can it be defined via a market price and therefore be disconnected from the traditional model of long term contracts? Our work shows that the unique use of a market price is not feasible. The characteristics of the sector set to continue using long term contracts to ensure long term security of supply. However, spot markets are fundamentals for the short term security of supply and for giving a price signal reflecting gas to gas competition. But for this to be true, it is recommended to remove the flexibility clauses from these long term contracts. Those contracts also need to be more indexed on spot prices. An illustration is given. At last, the use of Forward prices is questioned. Such a market would enable competition development and security of supply
Thivierge-Robitaille, Etienne. "L'amélioration de la prévisibilité des approvisionnements forestiers". Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/34602.
Texto completoIn recent years, the lack of wood supply predictability has been identified as a factor hindering the competitiveness of the forest sector. While several entities believe that the change in Quebec's forest regime in 2013 is one of the factors that led to this, it seems that the growing presence of a supplier-client relationship in wood procurement is also partially responsible. The problem of the lack of predictability is composed of two elements. First, no recognized definition of wood supply predictability has been proposed by the scientific community. Second, in practice, stakeholders do not seem to share a common understanding of what is wood supply predictability. In the absence of knowledge of the real causes of lack of predictability, it is difficult to come up with recommendations. To date, no study have addressed the issue of the lack of predictability of forest supplies. This work aims to fill this gap. A series of 20 interviews involving stakeholders of the forest supply chain was conducted. In addition, a case study of a Quebec pulp and paper mill examined wood supply predictability as part of procurement practices at the operational level. An evaluation methodology based on the data collection process in place, the contract allocation policy and the buyer forecasting methods have been applied. Based on our results, we define wood supply predictability as the ability to anticipate wood supply over time, within a certain degree of precision. 37 causes and 17 sources of the lack of wood supply predictability were identified through the interviews and the case study. These elements have been grouped into five categories. Finally, five causes specific to the management of suppliers and the monitoring of contractual agreements form the basis of recommendations aimed at improving predictability in the context of wood procurement. Four of the proposed recommendations favor contract allocation based on past performance of suppliers. A recommendation regarding quality monitoring of forecasts is also proposed.
Corbin, Elsa. "Enjeux et limites de l'introduction du supply chain management dans la chaîne logistique pharmaceutique : une perspective des grossistes répartiteurs portoricains". Antilles-Guyane, 2006. http://www.theses.fr/2006AGUY0580.
Texto completoIn United States, the pharmaceutical laboratories have decided to tackle the numerous sources of wastes existing in the pharmaceutical supply chain. Although we are still far from a generalization of these practices, as well we are far from a generalization of supply chain management practices in the pharmaceutical supply chain, lean manufacturing and the introduction of the Inventory Management Agreement (IMA) --announcing the beginning of a new era in the drug supply chain--are the new solutions introduced in order to reach a better pharmaceutical supply chain management The Inventory Management Agreement, signed between the pharmaceutical laboratories and the wholesalers -who, during years, managed the drug marketing channel-, should help today to leave behind speculative strategies in favour of practices permitting to decrease the level of stocks all along the drug supply chain. The transformations that the laboratories want to impulse reconsider the presence of the wholesalers as essential actors within the pharmaceutical supply chain. These ones are forced to introduce supply chain management practices as they do not want to be seen as an obstacle for an efficient management of the supply chain preventing them to be, in the future, maintained as a full actor within the drug supply chain
Ben, Dhif Allah Mohamed Bilel. "Choix de localisation et développement des start-ups de hautes technologies : Le cas des biotechnologies appliquées à la santé humaine en France". Paris 9, 2007. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=2007PA090057.
Texto completoBen, Ali Maha y Ali Maha Ben. "Approches intégrées de gestion de la demande dans l'industrie de bois d'œuvre". Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/36893.
Texto completoLes entreprises du bois d’oeuvre ont besoin d’une part de synchroniser les activités de production, d’approvisionnement et de ventes, et d’autre part, de maximiser les profits face à une demande hétérogène et saisonnière. L’objectif de cette thèse de doctorat est de développer et d’évaluer de nouvelles approches intégrées de gestion de la demande dans un contexte de capacité limitée, afin de mieux orienter ces entreprises de façon à maximiser les profits et à améliorer la satisfaction des clients les plus prioritaires. Le cas d’étude, inspiré de la réalité des entreprises du bois d’oeuvre québécoises, considère différents clients hétérogènes, des processus de production divergents et plusieurs usines oeuvrant dans un mode de fabrication pour les stocks, où les plans d’approvisionnement, de production et de ventes sont pilotés par les prévisions de la demande et des prix. Dans cette thèse, on commence par définir un cadre décisionnel mutiniveau afin de supporter les décisions d’allocation prises aux niveaux tactique et opérationnel, ainsi que les promesses de livraison conclues en temps réel. En particulier, on propose un processus de gestion de la demande intégrant la planification des ventes et des opérations (S&OP) avec la promesse de livraison basée sur les concepts de gestion des revenus : une nouvelle formulation mathématique, intégrant un modèle S&OP adapté à l’industrie du bois d’oeuvre et un modèle de promesse de livraison utilisant des limites de réservation imbriquées, est fournie. Cette formulation offre la possibilité de changer les décisions d’allocation en temps réel tant que les commandes fermes ne sont pas expédiées. Une plateforme d’optimisation et de simulation en horizon roulant est développée afin d’évaluer la valeur de l’intégration de la planification des ventes et des opérations et de la gestion des revenus. Les résultats de simulation ont démontré la capacité d’un processus intégrant le S&OP et la gestion des revenus, dans un contexte de capacité limitée et face à une demande hétérogène et saisonnière, à réaliser des meilleurs profits et à mieux satisfaire les clients prioritaires que les processus conventionnels de gestion de la demande. La plateforme d’optimisation et de simulation développée est utilisée, dans une seconde étape, pour étudier la performance de différents processus intégrés de gestion de la demande face à différentes situations du marché. En effet, on compare différentes séquences d’arrivée des commandes et deux approches de promesse de livraison. A cette fin, on adopte une nouvelle procédure de planification et d’analyse des expériences dans un contexte de gestion de la chaîne d’approvisionnement : un plan de remplissage d’espace est utilisé pour définir des scénarios variés du marché et des métamodèles de krigeage sont générés pour analyser les résultats. L’analyse des résultats a mis en évidence l’amélioration potentielle de performance qu’on peut atteindre en utilisant les concepts de gestion des revenus et a démontré l’impact de la séquence d’arrivée des commandes sur le profit annuel et le niveau de satisfaction des clients prioritaires. Les implications managériales qui découlent de cette analyse sont également présentées. Dans une troisième étape, on analyse l’effet de la substitution et de certains concepts de gestion des revenus. En particulier, on investigue l’intérêt d’offrir à certains clients privilégiés un produit de qualité supérieure au prix du produit original demandé (soit l’équivalent d’un sur-classement pour les entreprises de service), ce qui est une pratique assez commune dans l’industrie du bois d’oeuvre. À cette fin, on introduit la dimension produit dans le modèle de promesse de livraison basée sur les concepts de gestion des revenus et on mène une simulation en horizon roulant afin de comparer différentes approches intégrées de promesse de livraison. Les résultats de simulation soulignent l’efficacité d’une approche de promesse de livraison intégrant le sur-classement et les concepts de gestion des revenus, comparée aux pratiques communes utilisées pour satisfaire la demande dans un contexte de capacité limitée. En effet, le sur-classement s’avère significativement bénéfique s’il est associé aux concepts de gestion des revenus, vu que l’utilisation de limites de réservation empêche de proposer un sur-classement si le produit en question a été alloué à des commandes plus rentables.
This thesis addresses the need of softwood lumber firms operating in a supply-constrained environment and facing heterogeneous and seasonal market, to synchronize between the different business units of supply chain and to maximize profits. The objective is to develop and to evaluate new integrated demand management approaches for limited capacity contexts in a way to maximize profits and enhance the service level offered to high-priority customers. Our case study, inspired from softwood lumber manufacturers located in Eastern Canada, considers heterogeneous customers, divergent production processes and several mills considered as an MTS environment since operations and sales plans are driven by forecasts. In this thesis, we first define a multilevel decision framework in order to support mediumterm, short-term and real-time sales decisions. We propose a demand management process integrating sales and operations planning (S&OP) and revenue management (RM) concepts : we present a new mathematical formulation integrating an S&OP network model in the softwood lumber industry and an order promising model using nested booking limits. This formulation offers the possibility of changing decisions of how confirmed orders have to be fulfilled as late as possible, which we called order reassignment. Considering current demand management practices and existing IT-systems, we developed a simulationoptimization platform in order to evaluate the demand management process performance the benefits of integrating S&OP and RM concepts in various scenarios. Simulation results provide evidence of the value of integrating RM and S&OP and show that we can offer better service level to high-priority customers and higher profit margin compared to common demand management practices. The simulation-optimization platform is used, in a second step, to investigate how an integrated demand management process, that can be configured differently, can perform facing various order arrival sequences and market disturbances. For this purpose, we use relatively novel techniques – a space-filling design and Kriging metamodeling – in supply chain settings to address the impact of decision and environmental factors on the performance of the integrated demand management process. The simulation results affirm the use of nested booking limits can be a powerful tool to maximize revenues facing different environmental conditions. We also show how order arrival sequence can play a relevant role, especially with a high customer heterogeneity. In addition, as motivated by an industrial problem, we discuss the potential implications of the analysis presented for firms operating in supplyconstrained environments, such as Canadian softwood firms. As a third step, we investigate the benefits of integrating revenue management and product substitution in a manufacturing context. We particularly examine the situation when a higher quality substitute is provided at the original product’s price, which is called an upgrade. Upgrading is a common demand fulfillment practice in the Canadian softwood lumber industry. Thus, we generalize the order promising model using nested booking limits and we add a product dimension to enable product substitution. Then, we conduct a rolling horizon simulation in order to compare different demand fulfillment approaches. The simulation results demonstrate that integrating RM and upgrading achieves better performance than common demand fulfillment approaches in a limited capacity context. The value of upgrading is more significant when integrated with RM concepts since the use of nested booking limits prevents from doing unprofitable upgrades. Thus, inventories are preserved for future profitable orders.
This thesis addresses the need of softwood lumber firms operating in a supply-constrained environment and facing heterogeneous and seasonal market, to synchronize between the different business units of supply chain and to maximize profits. The objective is to develop and to evaluate new integrated demand management approaches for limited capacity contexts in a way to maximize profits and enhance the service level offered to high-priority customers. Our case study, inspired from softwood lumber manufacturers located in Eastern Canada, considers heterogeneous customers, divergent production processes and several mills considered as an MTS environment since operations and sales plans are driven by forecasts. In this thesis, we first define a multilevel decision framework in order to support mediumterm, short-term and real-time sales decisions. We propose a demand management process integrating sales and operations planning (S&OP) and revenue management (RM) concepts : we present a new mathematical formulation integrating an S&OP network model in the softwood lumber industry and an order promising model using nested booking limits. This formulation offers the possibility of changing decisions of how confirmed orders have to be fulfilled as late as possible, which we called order reassignment. Considering current demand management practices and existing IT-systems, we developed a simulationoptimization platform in order to evaluate the demand management process performance the benefits of integrating S&OP and RM concepts in various scenarios. Simulation results provide evidence of the value of integrating RM and S&OP and show that we can offer better service level to high-priority customers and higher profit margin compared to common demand management practices. The simulation-optimization platform is used, in a second step, to investigate how an integrated demand management process, that can be configured differently, can perform facing various order arrival sequences and market disturbances. For this purpose, we use relatively novel techniques – a space-filling design and Kriging metamodeling – in supply chain settings to address the impact of decision and environmental factors on the performance of the integrated demand management process. The simulation results affirm the use of nested booking limits can be a powerful tool to maximize revenues facing different environmental conditions. We also show how order arrival sequence can play a relevant role, especially with a high customer heterogeneity. In addition, as motivated by an industrial problem, we discuss the potential implications of the analysis presented for firms operating in supplyconstrained environments, such as Canadian softwood firms. As a third step, we investigate the benefits of integrating revenue management and product substitution in a manufacturing context. We particularly examine the situation when a higher quality substitute is provided at the original product’s price, which is called an upgrade. Upgrading is a common demand fulfillment practice in the Canadian softwood lumber industry. Thus, we generalize the order promising model using nested booking limits and we add a product dimension to enable product substitution. Then, we conduct a rolling horizon simulation in order to compare different demand fulfillment approaches. The simulation results demonstrate that integrating RM and upgrading achieves better performance than common demand fulfillment approaches in a limited capacity context. The value of upgrading is more significant when integrated with RM concepts since the use of nested booking limits prevents from doing unprofitable upgrades. Thus, inventories are preserved for future profitable orders.
Agi, Maher. "Analyse du développement d’une chaîne logistique par l’échange de données informatisé [EDI] : le cas d’un constructeur automobile". Paris, ENMP, 2005. http://www.theses.fr/2005ENMP1308.
Texto completoEDI is one of the most important tools in Supply Chain construction. Using data from a case study in the automotive industry, this work intended to analyse the conditions of EDI diffusion between a car manufacturer and his suppliers. Our case study helped us to develop and test a tool that uses uncertainty paradigm to analyse the importance of EDI connections for the car manufacturer. Also, our survey of suppliers shows that, despite standardization efforts and lower costs due to Internet, their integration to the manufacturer’s supply chain is still problematic. Findings from our study show that the most influent factors on suppliers’ decision regarding EDI adoption with the car manufacturer are the volume of exchanges and the existence of commercial prospects. Our analysis of supply chain integration strategies that car manufacturers could apply indicates that these latters could concentrate their purchase orders on some selected suppliers who would accept to establish EDI connections
Rozin, Philippe. "L’évaluation d'une politique de recherche fondamentale par la gestion interne des projets de recherche". Paris 10, 2007. http://www.theses.fr/2007PA100178.
Texto completoThis work deals with an analysis of the research projects in a big pharmaceutical laboratory. In this thesis, we propose an examination of different projects of research (fundamental research). This work is built in two parts. At first, we detail the internal conditions of evaluation of the projects (pre-molecules, financial allocations process) in a big pharmaceutics laboratory. We are insisting more particularly on the conditions of production of fundamental knowledge. We are more specifically interested in the tools of evaluation used by administrators, accountants and the scientific management to validate or push aside the projects of research. In the second part, we propose different models of estimation of the projects of research (model with and without memory) and a microeconomic study of the impact of the news on the volatility of the prise on stock exchange (GARCH and E-Garch multivariate model) based on Sanofi's volatily. We tend to demonstrate the existence of a short-termist model of evaluation
Zouikri, Messaoud. "Stratégies de R et D et innovation dans l’industrie pharmaceutique en France : une étude économétrique sur données individuelles". Paris 9, 2008. https://bu.dauphine.psl.eu/fileviewer/index.php?doc=2008PA090071.
Texto completoThe thesis puts forth an empirical methodology to study the link between modes of knowledge production and innovation, based on a functional (basic research, applied research and development) and organisational (internal research, external research) analysis of RD activities. To do so, it uses survey data on RD and innovation at the firm level in order to estimate through appropriate econometric models both the link between firm size and RD modes, and the relationship between RD strategies and innovation in the pharmaceutical industry in France. The main results show that the RD components increase non-linearly and less than proportionally with the size of the firm. Moreover, small and medium-sized firms are not significantly different from big firms in the production of original innovations. The different RD modes contribute to innovation in complementary ways
Ben, Ali Maha. "Approches intégrées de gestion de la demande dans l'industrie de bois d'œuvre". Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/36893.
Texto completoThis thesis addresses the need of softwood lumber firms operating in a supply-constrained environment and facing heterogeneous and seasonal market, to synchronize between the different business units of supply chain and to maximize profits. The objective is to develop and to evaluate new integrated demand management approaches for limited capacity contexts in a way to maximize profits and enhance the service level offered to high-priority customers. Our case study, inspired from softwood lumber manufacturers located in Eastern Canada, considers heterogeneous customers, divergent production processes and several mills considered as an MTS environment since operations and sales plans are driven by forecasts. In this thesis, we first define a multilevel decision framework in order to support mediumterm, short-term and real-time sales decisions. We propose a demand management process integrating sales and operations planning (S&OP) and revenue management (RM) concepts : we present a new mathematical formulation integrating an S&OP network model in the softwood lumber industry and an order promising model using nested booking limits. This formulation offers the possibility of changing decisions of how confirmed orders have to be fulfilled as late as possible, which we called order reassignment. Considering current demand management practices and existing IT-systems, we developed a simulationoptimization platform in order to evaluate the demand management process performance the benefits of integrating S&OP and RM concepts in various scenarios. Simulation results provide evidence of the value of integrating RM and S&OP and show that we can offer better service level to high-priority customers and higher profit margin compared to common demand management practices. The simulation-optimization platform is used, in a second step, to investigate how an integrated demand management process, that can be configured differently, can perform facing various order arrival sequences and market disturbances. For this purpose, we use relatively novel techniques – a space-filling design and Kriging metamodeling – in supply chain settings to address the impact of decision and environmental factors on the performance of the integrated demand management process. The simulation results affirm the use of nested booking limits can be a powerful tool to maximize revenues facing different environmental conditions. We also show how order arrival sequence can play a relevant role, especially with a high customer heterogeneity. In addition, as motivated by an industrial problem, we discuss the potential implications of the analysis presented for firms operating in supplyconstrained environments, such as Canadian softwood firms. As a third step, we investigate the benefits of integrating revenue management and product substitution in a manufacturing context. We particularly examine the situation when a higher quality substitute is provided at the original product’s price, which is called an upgrade. Upgrading is a common demand fulfillment practice in the Canadian softwood lumber industry. Thus, we generalize the order promising model using nested booking limits and we add a product dimension to enable product substitution. Then, we conduct a rolling horizon simulation in order to compare different demand fulfillment approaches. The simulation results demonstrate that integrating RM and upgrading achieves better performance than common demand fulfillment approaches in a limited capacity context. The value of upgrading is more significant when integrated with RM concepts since the use of nested booking limits prevents from doing unprofitable upgrades. Thus, inventories are preserved for future profitable orders.
Dupuy, Matthieu. "Contributions à l'analyse des systèmes industriels et aux problèmes d'ordonnancement à machines parallèles flexibles : application aux laboratoires de contrôle qualité en industrie pharmaceutique". Phd thesis, Toulouse, INPT, 2005. http://oatao.univ-toulouse.fr/7396/1/dupuy.pdf.
Texto completoPech-Gourg, Nicolas. "Méthodes d'optimisation appliquées à l'industrie du liège". Angers, 2002. http://www.theses.fr/2002ANGE0044.
Texto completoAttia, Agnès. "Mise en place et validation de documents dans un établissement pharmaceutique". Paris 5, 1999. http://www.theses.fr/1999PA05P197.
Texto completoLauras, Matthieu. "Méthodes de diagnostic et d'évaluation de performance pour la gestion de chaînes logistiques : application à la coopération maison-mère – filiales internationales dans un groupe pharmaceutique et cosmétique". Phd thesis, Toulouse, INPT, 2004. http://oatao.univ-toulouse.fr/7246/1/lauras.pdf.
Texto completoLegault-Michaud, Ariane. "Optimisation du processus d'approvisionnement des clients américains chez Groupe Leclerc". Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/36678.
Texto completoTahiri, Azedine. "Innovation par la responsabilité sociétale dans la gestion de projet d’ingénierie : cas de l’ingénierie pharmaceutique". Thesis, Saint-Etienne, EMSE, 2013. http://www.theses.fr/2013EMSE0682/document.
Texto completoThe integration of a sustainable development gait (SD) in the organizations implies, beyond the incentives, structured and structuring methods. These methods that we could name tools of implementation of SD are oriented toward a common objective: the global performance. Today very few methods are proposed to the societies of engineering in order to reach this global performance. It is probably due to the typological specificities of this type of organization. In point of fact, these engineering enterprises are quite atypical because they are shared between two universes which are the client (for instance pharmaceutical industry) and a significant number of complex subcontractors (SC). In this context, we approach our topic of research: the enterprise must prove that it is “economically viable, socially responsible and environmental healthy” (Quairel-Lanoizelee 2004), even beyond its own frontiers. But the answer to society’s expectations is also an element of the enterprise’s economic strategy. That is why, our idea is to suggest methodologies that are applicable to the engineering profession, and therefore could be adapted to all types of engineering enterprises, so that it can integrate a voluntary gait for SD by The Social Responsibility (SR). The International Organization for Standardization (ISO) is developing an international standard in order to provide guidelines for adopting and disseminating social responsibility: ISO 26000, which was published in 2010. In our research we have considered that the SR will play a double role, as reformer of the classical practices of project management as well as a tool that could bring SD strategy inside and outside the engineering organization. The general idea is to conceive a new approach of the enterprise’s management philosophy, disinterested from the unique profit notion. This brings us to think about another dimension of the enterprise’s performance. This project lead us to asking the following question: is it possible to manage an engineering project by including the SR approach in classical methodology of project management?By a methodology of action-research and specifically intervention-research (I-R), we are going to build our investigation about an international engineering company, which has as pharmaceutical engineering activity. The objective is to analyze, and to understand the specificities of engineering enterprise’s model in order to known if it is possible to change this model by developing a new project management approach based on the SR and strategy innovation. The innovating methodology that we developed must allow us to integrate a gait of SR within the best practice of engineering project. In conclusion, the integration tool of a gait of SR which is today on the stage of prototype, built on ISO 26000 norms and on the experimental norm Afnor X30-029 basis, allowed us to develop the pharmaceutical engineering’s profession, by moving from the standard engineering best practice to the social responsible engineering best practice, for a sustainable development goal
Ansart, Sylvain. "Les outils de gestion des Pharmaceutical benefit management". Paris 5, 1995. http://www.theses.fr/1995PA05P118.
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