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Tesis sobre el tema "Induced-neural stem cells"

Autor: Grafiati

Publicado: 11 de marzo de 2023

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1

Vicario, Nunzio. "Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/4088.

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Despite the remarkable beneficial effects of disease-modifying agents in relapsing-remitting multiple sclerosis (MS) patients, progressive forms of (P)MS still lack effective treatments. This stark contrast is partially dependent on the difficulties researchers have found in tackling the complex pathophysiology of this phase of disease, in which chronic inflammation within the central nervous system (CNS) is coupled by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immun

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2

Yoshimatsu, Masayoshi. "In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265189.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23417号<br>医博第4762号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授松田秀一特定拠点, 教授妻木範行, 教授安達泰治<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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3

Cullen, Daniel Kacy. "Traumatically-induced degeneration and reactive astrogliosis in three-dimensional neural co-cultures." Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11282005-210117/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2006.<br>Robert McKeon, Committee Member ; Robert Lee, Committee Member ; Robert Guldberg, Committee Member ; Ravi Bellamkonda, Committee Member ; Michelle LaPlaca, Committee Chair. Vita.

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4

McLaughlin, Heather Ward. "Modeling sporadic Alzheimer's disease using induced pluripotent stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094355.

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Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation and neuronal cell death are well-known from the post-mortem brain tissue of Alzheimer's disease patients, but research into the earliest stages of disease development is hindered by limited model systems. In this thesis, an in vitro human neuronal system was derived from induced pluripotent stem (iPS) cell lines reprogrammed from dermal fibroblasts of AD patients and ag

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5

Ma, Shuang. "Preoptic Regulatory Factor 2 Inhibits Proliferation and Enhances Drug Induced Apoptosis in Neural Stem Cells." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3353557.

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6

Alyamani, Najiah. "Molecular-genetics studies of organophosphate induced neurodegeneration in differentiating mammalian cell lines and neural progenitor stem cells." Thesis, Nottingham Trent University, 2018. http://irep.ntu.ac.uk/id/eprint/35003/.

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Organophosphorus (OP) pesticides are widely used despite evidence they cause neurotoxicity after exposure. The primary target for OPs is acetylcholinesterase, but there is evidence they can inhibit other cellular proteins including cytoskeletal and axon growth associated proteins, which are implicated in nervous system development. Furthermore, little is known about the ability of OPs to cause genotoxicity. The objectives of this study were to evaluate the effects of selected OPs on neurite outgrowth, expression of cytoskeletal proteins and associated gene expression levels, and to investigate

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7

Joshi, Ramila Joshi. "Micro-engineering of embryonic stem cells niche to regulate neural cell differentiation." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1544029342969082.

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8

Kandasamy, Majury [Verfasser], Andreas [Gutachter] Faissner, and Beate [Gutachter] Brand-Saberi. "Investigations on the generation of neural stem cells derived from human induced pluripotent stem cells / Majury Kandasamy ; Gutachter: Andreas Faissner, Beate Brand-Saberi." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/113135463X/34.

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9

Marzec-Schmidt, Katarzyna. "Deep convolutional neural networks accurately predict the differentiation status of human induced pluripotent stem cells." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19420.

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Rapid progress of AI technology in the life science area is observed in recent years. Convolutionalneural network (CNN) models were successfully applied for the localization and classification of cellson microscopic images. Induced pluripotent stem cells are one of the most important innovations inbiomedical research and are widely used, e.g. in regenerative medicine, drug screening, and diseasemodeling. However, assessment of cell cultures’ quality requires trained personnel, is timeconsumingand hence expensive. Fluorescence microscope images of human induced pluripotentstem‐hepatocytes (hiPS

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10

Cullen, Daniel Kacy. "Traumatically-Induced Degeneration and Reactive Astrogliosis in 3-D Neural Co-Cultures: Factors Influencing Neural Stem Cell Survival and Integration." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7584.

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Traumatic brain injury (TBI) results from a physical insult to the head and often results in temporary or permanent brain dysfunction. However, the cellular pathology remains poorly understood and there are currently no clinically effective treatments. The overall goal of this work was to develop and characterize a novel three-dimensional (3-D) in vitro paradigm of neural trauma integrating a robust 3-D neural co-culture system and a well-defined biomechanical input representative of clinical TBI. Specifically, a novel 3-D neuronal-astrocytic co-culture system was characterized, establishin

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11

Yoshikawa(Ogura), Aya. "γ-Secretase Inhibitors Prevent Overgrowth of Transplanted Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells". Kyoto University, 2013. http://hdl.handle.net/2433/174829.

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12

Glover, Hannah Jacquilyn. "L-proline-induced transition of mouse ES cells to a spatially distinct primitive ectoderm-like cell population primed for neural differentiation." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20576.

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Naïve mouse embryonic stem cells (mESCs) derived from the preimplantation mouse blastocyst self-renew in the presence of LIF and BMP4. These cells are pluripotent, meaning they have the ability to differentiate into the ~200 cell types of the developing embryo and adult. Naïve mESCs are one discrete state along a pluripotency continuum – delimited by ground-state mESCs as the earliest cell population, followed by naïve mESCs, and with EpiSCs as the most ‘primed’ population. The amino acid L-proline has novel growth factor-like properties during development - from improving blastocyst developme

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13

Chwastek, Damian. "Elucidating the Contribution of Stroke-Induced Changes to Neural Stem and Progenitor Cells Associated with a Neuronal Fate." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41839.

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Following stroke there is a robust increase in the proliferation of neural stem and progenitor cells (NSPCs) that ectopically migrate from the subventricular zone (SVZ) to surround the site of damage induced by stroke (infarct). Previous in vivo studies by our lab and others have shown that a majority of migrating NSPCs when labelled prior to stroke become astrocytes surrounding the infarct. In contrast, our lab has shown that the majority of NSPCs when labelled after stroke become neurons surrounding the infarct. This thesis aims to elucidate the contributions of intrinsic changes that can al

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14

Ngamjariyawat, Anongnad, Kyril Turpaev, Svitlana Vasylovska, Elena N. Kozlova, and Nils Welsh. "Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death." Uppsala universitet, Neuroanatomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198839.

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PURPOSE: Transplantation of pancreatic islets to Type 1 diabetes patients is hampered by inflammatory reactions at the transplantation site leading to dysfunction and death of insulin producing beta-cells. Recently we have shown that co-transplantation of neural crest stem cells (NCSCs) together with the islet cells improves transplantation outcome. The aim of the present investigation was to describe in vitro interactions between NCSCs and insulin producing beta-TC6 cells that may mediate protection against cytokine-induced beta-cell death. PROCEDURES: Beta-TC6 and NCSC cells were cultured ei

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15

Makedonopoulou, Paraskevi. "Studying the molecular consequences of the t(1;11) balanced translocation using iPSCs derived from carriers and within family controls." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25871.

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Schizophrenia is a major psychiatric disorder that affects 1% of the world population and is among the 10 leading worldwide causes of disability. Disrupted-In- Schizophrenia (DISC1) is one of the most studied risk genes for mental illness and is disrupted by a balanced translocation between chromosomes 1 and 11 that co-segregates with major mental illness in a single large Scottish family. DISC1 is a scaffold protein with numerous interactors and has been shown to hold key roles in neuronal progenitor proliferation, migration, cells signalling and synapse formation and maintenance. The studies

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16

Cheng, Tianci [Verfasser], and Matthias [Akademischer Betreuer] Morgalla. "GABAergic neural stem cells transplantation after spinal cord injury induced chronic neuropathic pain in a rat model / Tianci Cheng ; Betreuer: Matthias Morgalla." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1182985920/34.

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Camnasio, S. "IL RUOLO DELL¿HUNTINGTINA NELLA FISIOLOGIA DEL DIFFERENZIAMENTO NEURONALE E NELLA PATOLOGIA." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229428.

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Huntingtin (htt) is the 3,144 amino acid protein whose mutation causes Huntington’s disease (HD). Mutant htt is toxic for brain neurons, but the mechanism leading to pathology is still far from being understood. Moreover, since loss of wild type (WT) htt contributes to pathogenesis, the study of htt’s role and the effect of its depletion, in the central nervous system becomes important. In this Thesis we analyse complementarily the role of WT and mutant htt in physiological and pathological conditions. In the first part, it is described a novel role of WT htt during neural development. This

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18

Cho, Taesup. "Neural stem cell transplantation : neuroprotection and LTP-induced facilitation of neurogenesis." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36960.

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Transplantation of neural progenitor cells (NPC) constitutes a putative therapeutic maneuver for use in treatment of neurodegenerative diseases. At present, effects of NPC transplantation in the Alzheimer’s disease (AD) brain are largely unknown and a primary objective of this work is to demonstrate possible efficacy of NPC administration in an AD animal model. The benefits of transplantation could involve a spectrum of effects including replacement of endogenous neurons, conferring neuroprotection with enhancement of neurotrophic factors, and diminishing levels of neurotoxic agents. Additiona

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19

Yulius, Hermanto. "Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia." Kyoto University, 2019. http://hdl.handle.net/2433/242389.

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20

Nishimura, Koji. "Transplantation of murine induced pluripotent stem cell-derived neural progenitors into the cochlea." Kyoto University, 2012. http://hdl.handle.net/2433/157416.

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21

Hadoux, Julien. "Modélisation des néoplasies endocriniennes multiples de type II par les cellules souches pluripotentes induites porteuses de mutations germinales du gène RET." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS389/document.

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Les cellules souches pluripotentes induites (CSPi) permettent la modélisation de processus avec, en oncologie, un intérêt potentiel pour la modélisation de syndromes de prédisposition au cancer liés à des mutations germinales d’oncogènes. Nous avons généré des lignées de CSPi à partir de patients atteints de néoplasies endocriniennes multiples de type 2 (NEM2), porteurs de mutations germinales du gène RET : RETC620R, RETC634Y et RETM918T. Nous avons généré une CSPi RETY634C, contrôle isogénique, par correction de la mutation RETC634Y via CRSPR/Cas9. Ces CSPi présentent tous les critères de plu

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22

Zhang, Qi [Verfasser]. "Immunohistochemical Study of Spinal Cord Injury Induced Neuropathic Pain with GABAergic Neural Stem Cell Transplantation Treatment / Qi Zhang." Tübingen : Universitätsbibliothek Tübingen, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1190103.

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23

Mokrani, Sofiane. "Maintenance de la stabilité chromosomique des cellules souches neurales murines au cours du développement et après un stress génotoxique aiguë ou chronique Impaired brain development and behavior of Xlf null mice linked to chromosome instability-induced premature neurogenesis Higher Chromosome Stability in Mouse Embryonic Neural Stem and Progenitor Cells than in Fibroblasts in Response to Acute or Chronic Genotoxic Stress." Thesis, Institut polytechnique de Paris, 2019. http://www.theses.fr/2019IPPAX010.

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Une exposition prénatale aux radiations ionisantes est associée au développement de pathologies neurodéveloppementales liées à l’induction de dommages à l’ADN dans les cellules souches et progéniteurs neuraux (CSPN). Ainsi, la stabilité génétique des CSPN est cruciale pour le développement et l’homéostasie du cerveau. Cependant, des altérations génomiques au niveau des CSPN au cours du développement pourraient promouvoir la diversité neuronale. XLF est un composant de la voie de réparation d’ADN par NHEJ (pour Non-Homologous End-Joining). Nous avons montré une augmentation de l’instabilité des

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24

Sun, Jianan. "Protective Effects of Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 Mice." Kyoto University, 2016. http://hdl.handle.net/2433/215387.

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25

Mozafari, Sabah. "Characterization of neural precursors derived from iPSCs in vitro and in vivo after transplantation into the demyelinated central nervous system." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066091/document.

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Les précurseurs neuraux dérivés de cellules souches pluripotentes induites (iPS-NPCs) peuvent représenter la source cellulaire autologue idéale pour la thérapie cellulaire visant à promouvoir la remyélinisation et la neuroprotection des maladies de la myéline. Jusqu'à présent, le potentiel thérapeutique de ces cellules a été abordé dans des conditions néonatales. Cependant, l'efficacité de la réparation et de la sécurité de ces cellules dans le système nerveux central (SNC), une condition associée à une diminution de la plasticité cellulaire et effarouchement, reste à être bien traités. D'aill

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26

Tegas, Antonio Vasile. "Finite element modeling of flow/compression-induced deformation of alginate scaffolds for bone tissue engineering." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10209/.

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Trauma or degenerative diseases such as osteonecrosis may determine bone loss whose recover is promised by a "tissue engineering“ approach. This strategy involves the use of stem cells, grown onboard of adequate biocompatible/bioreabsorbable hosting templates (usually defined as scaffolds) and cultured in specific dynamic environments afforded by differentiation-inducing actuators (usually defined as bioreactors) to produce implantable tissue constructs. The purpose of this thesis is to evaluate, by finite element modeling of flow/compression-induced deformation, alginate scaffolds intended

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27

Huang, Wen-Chin, and 黃文勤. "Study of Differences in Neural Differentiation between Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/93079414896212544778.

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碩士<br>國立臺灣大學<br>解剖學暨生物細胞學研究所<br>99<br>Embryonic stem cells (ESCs) possess powerful ability to self-renew and to differentiate into all cell types of three germ layers. It has been reported that induced pluripotent stem cells (iPSCs) derived from somatic cells have been generated by transfecting four transcription factors including Oct4, Sox2, Klf4 and c-Myc. iPSCs provide advantages in various applications, such as developmental studies, pharmaceutical screening, and autologous cell transplantation. iPSCs have also showed powerful ability of self-renewal and differentiation into a variety of c

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Huang, Hsin-Yi, and 黃欣儀. "Molecular Mechanism Undelying Urocortin-Induced Anti-Proliferation in Neural Stem Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/11864528307599981665.

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博士<br>慈濟大學<br>醫學科學研究所<br>99<br>During corticogenesis, the proliferation and differentiation in neural stem cells are regulated precisely by a balance of extrinsic and intrinsic factors which direct progression into or exit from the cell cycle, and then determine the cortical cytoarchitecture. Urocortin (UCN), a member of the corticotrophin releasing hormone (CRH), is widely expressed in the adult brain and is involved in the functions of neuroprotection, stress response, immune suppression, and dendrite outgrowth. Although limited studies indicate UCN is expressed in the developing cortex, its

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29

"Generation and characterization of induced neural cells from fibroblasts by defined factors." 2011. http://library.cuhk.edu.hk/record=b5894654.

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Tse, Chi Lok.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 116-131).<br>Abstracts in English and Chinese.<br>Declaration --- p.i<br>Abstract --- p.iii<br>Abstract in Chinese --- p.v<br>Acknowledgements --- p.vi<br>Table of Contents --- p.vii<br>List of Figures --- p.X<br>List of Tables --- p.xii<br>List of Abbreviations --- p.xiii<br>Chapter CHAPTER 1 --- General Introduction<br>Chapter 1.1 --- Regenerative Medicine --- p.1<br>Chapter 1.2 --- Embryonic Stem Cells and Reprogramming --- p.3<br>Chapter 1.3 --- Transdifferenti

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De, la Vega Reyes Laura. "Novel techniques for engineering neural tissue using human induced pluripotent stem cells." Thesis, 2019. http://hdl.handle.net/1828/11427.

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Tissue engineering (TE) uses a combination of biomaterial scaffolds, cells, and drug delivery systems (DDS) to create tissues that resemble the human physiology. Such engineered tissues could be used to treat, repair, replace, and augment damaged tissues or organs, for disease modeling, and drug screening purposes. This work describes the development and use of novel strategies for engineering neural tissue using a combination of drug delivery systems (DDS), human induced pluripotent stem cells (hiPSCs), and bioprinting technologies for the generation of a drug screening tool to be used in the

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31

Lai, Chien-Cheng, and 賴建成. "Comparison of Neural Function of Normal Cells and Mucopolysaccharidosis Type II Cells Studied by Induced Pluripotent Stem Cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/50469578440109042692.

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Khadem, Mohtaram Nima. "Development of Multiscale Electrospun Scaffolds for Promoting Neural Differentiation of Induced Pluripotent Stem Cells." Thesis, 2014. http://hdl.handle.net/1828/5758.

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Electrospun biomaterial scaffolds can be engineered to support the neural differentiation of induced pluripotent stem cells. As electrospinning produces scaffolds consisting of nano or microfibers, these topographical features can be used as cues to direct stem cell differentiation. These nano and microscale scaffolds can also be used to deliver chemical cues, such as small molecules and growth factors, to direct the differentiation of induced pluripotent stem cells into neural phenotypes. Induced pluripotent stem cells can become any cell type found in the body, making them a powerful tool fo

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BRAGA, ALICE. "TOWARDS A COMBINATION THERAPY FOR SPINAL CORD INJURY: PRNA-3WJ NANOTHERAPEUTICS AND TRANSPLANTATION OF INDUCED-NEURAL STEM CELLS." Doctoral thesis, 2017. http://hdl.handle.net/11562/965010.

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Spinal cord injury (SCI) is a debilitating pathology that has increased in prevalence over the last few decades. Despite improvements in modern medicine leading to a normal life expectancy, there are limited treatment options and still no fully restorative therapies. Several experimental therapies have been employed to ameliorate the hostile injured environment, amongst which stem cell transplantation is a standout. Neural stem cell (NSC) transplantation has shown promising results in promoting functional recovery in SCI models. However, major accessibility, ethical and immunocompatibility iss

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BIDOLLARI, ERIS. "Neural stem cells differentiated from human induced pluripotent stem cells (iPSCs) as a novel in vitro model to study developmental pathways in Huntington Disease." Doctoral thesis, 2017. http://hdl.handle.net/11573/1058534.

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Huntington Disease (HD) is an autosomal dominant disorder characterized by motor, cognitive and behavioral features caused by a CAG expansion in the HTT (huntingtin) gene beyond 35 repeats. Since the discovery of the HTT mutation 24 years ago, more than 15,000 papers have been published on HD. However, both the role of the huntingtin (wtHTT) in healthy individuals and the molecular mechanisms by which the mutated huntingtin causes the disease remain unclear. The discovery of induced pluripotent stem cell (iPSC) technology offer the possibility to generate patient-specific iPS cells and to enab

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Lo, Wen-Cheng, and 羅文成. "Automatic Class Labeling of Human Induced Pluripotent Stem Cells in Microscopy Images using Convolutional Neural Networks." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/m5eaaz.

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碩士<br>中原大學<br>資訊工程研究所<br>107<br>This paper proposes an automatic class labeling system for human induced Pluripotent Stem cells (iPS cells) in microscopy images. The system uses a pre-trained convolutional neural network (CNN) classifier as the basis for classification, and produces color-coded images with class probabilities. There are a total of 4 classes, each of which represents the proliferation process of human iPS cells. The CNN used in our system consists of convolutional layers, max pooling, average pooling, and a fully connected layer, called iPSNet, was designed and evaluated using

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Montgomery, Amy. "Combining induced pluripotent stem cells and fibrin matrices for spinal cord injury repair." Thesis, 2014. http://hdl.handle.net/1828/5272.

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Spinal cord injuries result in permanent loss of motor function, leaving those affected with long term physical and financial burdens. Strategies for spinal cord injury repair must overcome unique challenges due to scar tissue that seals off the injury site, preventing regeneration. Tissue engineering can address these challenges with scaffolds that serve as cell- and drug-delivery tools, replacing damaged tissue while simultaneously addressing the inhibitory environment on a biochemical level. To advance this approach, the choice of cells, biomaterial matrix, and drug delivery system must be

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Agbay, Andrew. "Development of guggulsterone-releasing microspheres for directing the differentiation of human induced pluripotent stem cells into neural phenotypes." Thesis, 2017. https://dspace.library.uvic.ca//handle/1828/8316.

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In the case of Parkinson’s disease, a common neurodegenerative disorder, the loss of motor function results from the selective degeneration of dopaminergic neurons (DNs) in the brain. Current treatments focus on pharmacological approaches that lose effectiveness over time and produce unwanted side effects. A more complete concept of rehabilitation to improve on current treatments requires the production of DNs to replace those that have been lost. Although pluripotent stem cells (PSCs) are a promising candidate for the source of these replacement neurons, current protocols for the terminal dif

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"From Autopsy Donor to Stem Cell to Neuron (and Back Again): Cell Line Cohorts, IPSC Proof-of-Principle Studies, and Transcriptome Comparisons of In Vitro and In Vivo Neural Cells." Doctoral diss., 2013. http://hdl.handle.net/2286/R.I.18696.

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abstract: Induced pluripotent stem cells (iPSCs) are an intriguing approach for neurological disease modeling, because neural lineage-specific cell types that retain the donors' complex genetics can be established in vitro. The statistical power of these iPSC-based models, however, is dependent on accurate diagnoses of the somatic cell donors; unfortunately, many neurodegenerative diseases are commonly misdiagnosed in live human subjects. Postmortem histopathological examination of a donor's brain, combined with premortem clinical criteria, is often the most robust approach to correctly classi

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Dubišová, Jana. "Léčba poranění míchy pomocí transplantace různých typů kmenových buněk." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331126.

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Spinal cord injury (SCI) is complicated injury with serious socioeconomic consequences for the patient and his whole family. Big difficulty cause also extremely high living expenses for the patient with this type of injury. That's why there is a need for therapeutic methods which would help patients after SCI to recover the lost functions and be able at least partially to return to their normal life. Different therapeutic methods are being used for SCI treatment. In this study we used four various types of stem cells: human bone marrow stem cells (hBM-MSCs), human umbilical cord mesenchymal st

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Rybová, Jitka. "Patobiochemie lysosomálních střádavých onemocnění: studie Fabryho nemoci a příprava buněčných modelů X-vázaných chorob." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-388707.

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Human autopsy or biopsy tissue samples, mouse models and cell cultures of various types represent the most common materials in the investigation of cell pathogenesis of inherited diseases. This dissertation is devoted to all these approaches in the study of two X-linked lysosomal storage diseases, Fabry disease (FD,α-galactosidase A (AGAL) deficiency) and mucopolysaccharidosis type II (MPSII, idunorate-2- sulfatase (IDS) deficiency). The primary goal of the work was analysis of lipid blood group B antigens with terminal α-galactose (B-GSL) in the pancreas of FD patients with blood group B (FD-

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Lin, Cheng-Yu, and 林政宇. "Convolutional Neural Networks with an Application on Human Induced Pluripotent Stem Cell Region Recognition Using Microscopy Images." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/92385542870545928601.

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碩士<br>中原大學<br>資訊工程研究所<br>105<br>We present a deep learning architecture Convolutional Neural Networks (CNNs) for automatic classification and recognition of reprogramming and reprogrammed human Induced Pluripotent Stem (iPS) cell regions in microscopy images. The differentiated cells that possibly undergo reprogramming to iPS cells can be detected by this method for screening reagents or culture conditions in iPS induction. The learning results demonstrate that our CNNs can achieve the Top-1 and Top-2 error rates of 5.9% and 0.9%, respectively, to produce probability maps for the automatic ana

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Chao, Che-Wei, and 趙哲瑋. "PartI: The effect of laminin surface - modified silica nanofiber scaffold on neural stem cell differentiationPartII: Neuroprotective effect of EGCG on LPS - induced Parkinson''s disease in rats." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/18176000070437979542.

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碩士<br>中原大學<br>奈米科技碩士學位學程<br>105<br>PartI: Electrospun fibrous scaffolds have been widely applied in tissue engineering. The objective of this study was developing aligned and random silica nanofiber scaffolds with and without laminin to evaluate the potential of rat neural stem cells (rNSCs) for neural differentiation. Herein, we used various methods such as trypan blue exclusion test, MTS assay, real-time polymerase chain reaction, and immunocytochemistry to evaluate the effects of the scaffolds on cell adhesion, cellular viability, and neuron-specific gene expression of the cells. The result

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