Bibliografías temáticas / Indomethacin

Literatura académica sobre el tema "Indomethacin"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 1 de marzo de 2023

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros

Elija tipo de fuente:

Índice

Consulte las listas temáticas de artículos, libros, tesis, actas de conferencias y otras fuentes académicas sobre el tema "Indomethacin".

Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.

También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.

Artículos de revistas sobre el tema "Indomethacin"

1

Sataraddi, Sanjeevaraddi R., Shreekant M. Patil, Atmanand M. Bagoji, Vijay P. Pattar y Sharanappa T. Nandibewoor. "Electrooxidation of Indomethacin at Multiwalled Carbon Nanotubes-Modified GCE and Its Determination in Pharmaceutical Dosage Form and Human Biological Fluids". ISRN Analytical Chemistry 2014 (30 de marzo de 2014): 1–9. http://dx.doi.org/10.1155/2014/816012.

Texto completo
Resumen
A simple, rapid, selective, and sensitive electrochemical method for the direct determination of indomethacin was developed. The electrochemical behavior of indomethacin was carried at multiwalled carbon nanotube- (MWCNTs-) modified glassy carbon electrode (GCE). The cyclic voltammetric results indicated that MWCNT-modified glassy carbon electrode remarkably enhanced electrocatalytic activity towards the oxidation of indomethacin in slightly acidic solutions. It led to a considerable improvement of the anodic peak current for indomethacin and could effectively accumulate at this electrode and produce two anodic peaks at 0.720 V and 0.991 V, respectively, and one reduction peak at 0.183 V. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the determination of indomethacin by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.2 to 6.0 μM and 13.2 nM, respectively. The proposed method was successfully applied to determination of Indomethacine in pharmaceutical samples. The analytical performance of this sensor has been evaluated for detection of analyte in human serum and urine as real samples.
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

&NA;. "Indomethacin see Flurbiprofen/indomethacin". Reactions Weekly &NA;, n.º 367 (septiembre de 1991): 8. http://dx.doi.org/10.2165/00128415-199103670-00041.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

&NA;. "Indomethacin see Cocaine + indomethacin". Reactions Weekly &NA;, n.º 378 (noviembre de 1991): 6. http://dx.doi.org/10.2165/00128415-199103780-00026.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

&NA;. "Indomethacin see Diclofenac/indomethacin". Reactions Weekly &NA;, n.º 325 (noviembre de 1990): 9. http://dx.doi.org/10.2165/00128415-199003250-00035.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

&NA;. "Indomethacin". Reactions Weekly &NA;, n.º 696 (abril de 1998): 8. http://dx.doi.org/10.2165/00128415-199806960-00024.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

&NA;. "Indomethacin". Reactions Weekly &NA;, n.º 541 (marzo de 1995): 7. http://dx.doi.org/10.2165/00128415-199505410-00028.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

&NA;. "Indomethacin". Reactions Weekly &NA;, n.º 547 (abril de 1995): 7. http://dx.doi.org/10.2165/00128415-199505470-00017.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

&NA;. "Indomethacin". Reactions Weekly &NA;, n.º 575 (noviembre de 1995): 8. http://dx.doi.org/10.2165/00128415-199505750-00021.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

&NA;. "Indomethacin". Reactions Weekly &NA;, n.º 596 (abril de 1996): 8. http://dx.doi.org/10.2165/00128415-199605960-00025.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

&NA;. "Indomethacin". Reactions Weekly &NA;, n.º 597 (abril de 1996): 8. http://dx.doi.org/10.2165/00128415-199605970-00023.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Tesis sobre el tema "Indomethacin"

1

Hollingsworth, Simon John. "Protentiation of methotrexate cytotoxicity by indomethacin". Thesis, King's College London (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281631.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Martin, Steven William. "Study of indomethacin-induced gastric mucosal damage". Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316437.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Brodowicz, Gary Ray. "Exercise training, indomethacin, and isoproterenol-induced myocardial necrosis /". The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487265555440899.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Priebe, Milissa Ann. "Clinical implications of indomethacin superfused over the capillaries of frogs with activated white blood cells". Thesis, Montana State University, 2010. http://etd.lib.montana.edu/etd/2010/priebe/PriebeM0510.pdf.

Texto completo
Resumen
Treatment for inflammation is controversial. The purpose of this study was to investigate the effect of indomethacin on capillary permeability in animals with signs of systemic inflammation. We hypothesized that the permeability of an individual capillary would be lower after a shear stress challenge in the presence of indomethacin when evidence of systemic infection was present in the animal. Frogs (n=13) were pithed and the mesentery was exposed, hydraulic conductivity (L p) was assessed at 30 cm Hâ‚‚O using the modified Landis technique after an abrupt change in shear stress. Two capillaries from each frog were used; one was a control and one with indomethacin superfused over the tissue. The frogs showed a systemic infection (nitro blue tetrazolium activation) but individual capillaries had no evidence of rolling or sticking white cells. There was a significant decrease in L p (P=0.002) when comparing the control and treatment vessels. The results of the analysis indicate capillary L p assessed in mesentery of infected frogs, decreased when exposed to shear stress and indomethacin. The data imply that gaps between endothelial cells may get smaller when indomethacin is introduced into the system decreasing the flow of fluids out of the capillary.
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Chokshi, Rina. "Evaluation of hot-melt extrusion technology to improve dissolution rates of poorly water soluble drugs /". View online ; access limited to URI, 2004. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3145415.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Kelly, David Andrew. "Changes in jejunal villous blood flow in response to indomethacin". Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286454.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Tan, Aiguo. "Thioredoxin-1 attenuates indomethacin-induced gastric mucosal injury in mice". Kyoto University, 2008. http://hdl.handle.net/2433/135862.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Warwick, Barry School of Chemical Engineering &amp Industrial Chemistry UNSW. "Synthesis, purification and micronisation of copper indomethacin using dense gas technology". Awarded by:University of New South Wales. School of Chemical Engineering and Industrial Chemistry, 2001. http://handle.unsw.edu.au/1959.4/17876.

Texto completo
Resumen
The primary aim of this work was to provide an alternative method of synthesis of the non-steroidal anti-inflammatory drug copper indomethacin (Cu-Indo) and to produce alternative forms of the drug to increase its marketability. Dense gases as anti-solvents were used to achieve these aims. The study involved the synthesis, purification, micronisation and co-precipitation of Cu-Indo with polyvinylpyrrolidone (PVP) using dense carbon dioxide as an anti-solvent. Initially the volumetric and solubility behaviours of the solvent???anti-solvent systems were investigated to determine the optimum processing conditions. The solubility of Cu-Indo in an expanded solution was found to be a complex function of the solvent and other solutes. Copper indomethacin was successfully synthesised and purified in a single vessel using dense carbon dioxide as an anti-solvent. Drug yields of 98 % and purities near 100 % were achieved at optimum conditions with the advantages of less residual solvent in the drug, less solvent waste, reduced processing time and increased yields over the conventional synthesis process. Copper indomethacin was produced in a variety of morphologies and particle sizes using dense carbon dioxide as an anti-solvent. An investigation of the effect of process parameters on the particle characteristics showed that solute concentration was the dominant variable. Spherical particles with diameters less than 8 mm were obtained at optimum conditions. The immediate benefit of micronising Cu-Indo was demonstrated with an eight fold increase in dissolution rate when compared to the conventionally produced drug. Polyvinylpyrrolidone was successfully co-precipitated with Cu-Indo using dense carbon dioxide as an anti-solvent. The PVP???Cu-Indo co-precipitates were found to increase the solubility of the drug in ethanol with a 36 fold solubility enhancement at optimum conditions. The use of dense carbon dioxide as anti-solvent in this work demonstrates the potential of the GAS and ASES processes in the pharmaceutical industry. Copper indomethacin was synthesised, purified and micronised in a single vessel at a substantial saving in terms of time and solvent usage. The micronisation of Cu-Indo and the formation of the PVP???Cu-Indo co-precipitate provided alternative forms of the drug substantially increasing its marketability.
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Roberts, A. A. "The polymerisation state of sodium hyaluronate and the in vivo and in vitro influence of indomethacin". Thesis, University of Salford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381738.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Battu, Ganga Rao. "Anti-inflammatory and phytochemical studies of a Kenyan traditional medicinal plant, Commiphora kua". Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366837.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Libros sobre el tema "Indomethacin"

1

Alexis, Neil. Effects of indomethacin pretreatment on short-term ozone exposure in asthmatics. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1998.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Parker, James N. y Philip M. Parker. Indomethacin: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Roberts, Andrew Aubrey. The polymerisation state of sodium hyaluronate and the In Vivo and In Vitro influence of indomethacin. Salford: University of Salford, 1987.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Al-Saggaff, Omer Taha. In-vivo studies on the effect of furosemide and indomethacin at different levels of sodium intake on renal prostanoids, sodium excretion, associated hormones and other renal function perameters. Uxbridge: Brunel University, 1988.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Spivey, Timothy. INDOMETHACIN: Indomethacin Medication Used for Treating Modest to Severe Rheumatoid Arthritis, Osteoarthritis, and Gouty Arthritis. Independently Published, 2019.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Blokdijk, G. J. Indomethacin; A Clear and Concise Reference. CreateSpace Independent Publishing Platform, 2018.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Mather, Gary G. Immunomodulation of carcinogenesis by interferon interleukin 2 and indomethacin. 1989.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Cosola-Smith, Carrie A. Bovine luteal oxytocin synthesis and secretion in vitro: Effects of phorbol ester, calcium ionophore and indomethacin. 1989.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Stevens, Mark Gregory. Augmentation of murine alveolar macrophage functions by gamma interferon and indomethacin. 1988, 1988.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Publications, ICON Health. Indomethacin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications, 2004.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Capítulos de libros sobre el tema "Indomethacin"

1

Maxwell, Robert A. y Shohreh B. Eckhardt. "Indomethacin". En Drug Discovery, 209–19. Totowa, NJ: Humana Press, 1990. http://dx.doi.org/10.1007/978-1-4612-0469-5_16.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

de Groot, Anton C. "Indomethacin". En Monographs In Contact Allergy, 527. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003158004-260.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

van Overmeire, Bart. "Comparison of Indomethacin and Ibuprofen". En Interventions for Persisting Ductus Arteriosus in the Preterm Infant, 65–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-26509-0_13.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Terhaag, B. "The Biliary Elimination of Indomethacin in Man". En Archives of Toxicology, 359–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-69928-3_73.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Colombo, Paolo, Ubaldo Conte, Andrea Gazzaniga, Carla Caramella y Aldo Manna. "A New Indomethacin Lysinate Modified Release System". En Polymers in Medicine II, 369–77. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-1809-5_27.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Lau, C. K., W. C. Black, M. Belley, C. Chan, S. Charleson, D. Denis, J. Y. Gauthier et al. "From Indomethacin to a Selective Cox-2 Inhibitor". En Advances in Experimental Medicine and Biology, 73–78. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1813-0_11.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Bogucki, Andrzej y Wojciech Kozubski. "Indomethacin Does Not Inhibit Nitroglycerin-Provoked Cluster Headache Attack". En Updating in Headache, 312–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-88581-5_51.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Franconi, Flavia, Mauro Miceli, Federico Bennardini, Antonella Mattana, Jesus Covarrubias y Giuseppe Seghieri. "Taurine Potentiates the Antiaggregatory Action of Aspirin and Indomethacin". En Advances in Experimental Medicine and Biology, 181–86. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3436-5_20.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Tasić, L. J., J. Milić, M. Primorac, M. Stupar y S. Simović. "The Effect of Cellulose Ethers on Indomethacin/Cyclodextrin Complexation". En Proceedings of the Ninth International Symposium on Cyclodextrins, 269–72. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4681-4_62.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Sirois, Jean, Jianmin Liu, Derek Boerboom y Martine Antaya. "Prostaglandins and Ovulation: From Indomethacin to PGHS-2 Knockout". En Ovulation, 208–18. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-0-387-21508-2_18.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.

Actas de conferencias sobre el tema "Indomethacin"

1

Bansal, Arvind, Sameer Modi y Ajay Dantuluri. "Nanocrystalline Solid Dispersions of Indomethacin with Hydrophilic Polymers". En The 1st Electronic Conference on Pharmaceutical Sciences. Basel, Switzerland: MDPI, 2011. http://dx.doi.org/10.3390/ecps2011-00515.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Mihai, Ion Bogdan, Maria Minodora Marin, Mihaela Violeta Ghica, Madalina Georgiana Albu-Kaya, Laurentiu Christian Dinca, Diana Dragusin y Cristina-Elena Dinu-Pirvu. "Collagen-Indomethacin-Hydroxyapatite Spongious Forms for Bone Reconstruction Treatment". En The 6th International Conference on Advanced Materials and Systems. INCDTP - Division: Leather and Footwear Research Institute, Bucharest, RO, 2016. http://dx.doi.org/10.24264/icams-2016.ii.17.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Wojdyla, P., A. Xie, D. Pegelow, S. Barczi y J. Dempsey. "Carotid Body Is Not Involved in Indomethacin-Induced Hyperventilation." En American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6334.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Zaczek, Adam J. y J. Axel Zeitler. "Analysis of Glass Transition Temperatures in Indomethacin/Polymer Mixtures". En 2019 44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz). IEEE, 2019. http://dx.doi.org/10.1109/irmmw-thz.2019.8873702.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Ornik, Jan, Lara Heidrich, Robert Schesny, Cornelia M. Keck, Enrique Castro-Camus y Martin Koch. "THz TDS of SmartFilms® Loaded with Indomethacin". En 2021 46th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2021. http://dx.doi.org/10.1109/irmmw-thz50926.2021.9567409.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Xiang Hu, Hongtao Zheng, Hong Zhu, Xin Wu y Zhengshan He. "Electrocatalytic oxidation of indomethacin on a modified carbon nanotube electrode". En 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5966120.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Altan, Semih. "Role of Indomethacin in Corneal Neovascularization in Acid Burn of Rabbits". En 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-246.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Monique Rocha Bonetti, Flávia, Eneida de Paula y LÍGIA NUNES DE MORAIS RIBEIRO. "Gastrorresistant bio-hybrid beads for indomethacin delivery aiming the oral route". En XXV Congresso de Iniciação Cientifica da Unicamp. Campinas - SP, Brazil: Galoa, 2017. http://dx.doi.org/10.19146/pibic-2017-78505.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Brown, Derek W., Jennifer Hadway y Ting-Yim Lee. "CT measurement of indomethacin-induced cerebral hemodynamic changes in the newborn piglet". En Medical Imaging 2003, editado por Anne V. Clough y Amir A. Amini. SPIE, 2003. http://dx.doi.org/10.1117/12.480418.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Sipos, Bence, Ildikó Csóka y Gábor Katona. "Spray-dried indomethacin-loaded polymeric micelles for the improvement of peroral bioavailability". En IV. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2022. http://dx.doi.org/10.14232/syrptbrs.2022.18.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.

Informes sobre el tema "Indomethacin"

1

Du, Fei, Hengxin Shi, Yongxuan Zhang y Li Ren. Is indomethacin and diclofenac combined with other drugs more effective in preventing pancreatitis after endoscopic cholangiopancreatography? Answers from a Bayesian network meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, octubre de 2021. http://dx.doi.org/10.37766/inplasy2021.10.0086.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Meidan, Rina y Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, marzo de 1995. http://dx.doi.org/10.32747/1995.7604935.bard.

Texto completo
Resumen
The main goal of this research plan was to elucidate regulatory mechanisms controlling the development, function of the bovine corpus luteum (CL). The CL contains two different sterodigenic cell types and therefore it was necessary to obtain pure cell population. A system was developed in which granulosa and theca interna cells, isolated from a preovulatory follicle, acquired characteristics typical of large (LL) and small (SL) luteal cells, respectively, as judged by several biochemical and morphological criteria. Experiments were conducted to determine the effects of granulosa cells removal on subsequent CL function, the results obtained support the concept that granulosa cells make a substaintial contribution to the output of progesterone by the cyclic CL but may have a limited role in determining the functional lifespan of the CL. This experimental model was also used to better understand the contribution of follicular granulosa cells to subsequent luteal SCC mRNA expression. The mitochondrial cytochrome side-chain cleavage enzyme (SCC), which converts cholesterol to pregnenolone, is the first and rate-limiting enzyme of the steroidogenic pathway. Experiments were conducted to characterize the gene expression of P450scc in bovine CL. Levels of P450scc mRNA were higher during mid-luteal phase than in either the early or late luteal phases. PGF 2a injection decreased luteal P450scc mRNA in a time-dependent manner; levels were significantly reduced by 2h after treatment. CLs obtained from heifers on day 8 of the estrous cycle which had granulosa cells removed had a 45% reduction in the levels of mRNA for SCC enzymes as well as a 78% reduction in the numbers of LL cells. To characterize SCC expression in each steroidogenic cell type we utilized pure cell populations. Upon luteinization, LL expressed 2-3 fold higher amounts of both SCC enzymes mRNAs than SL. Moreover, eight days after stimulant removal, LL retained their P4 production capacity, expressed P450scc mRNA and contained this protein. In our attempts to establish the in vitro luteinization model, we had to select the prevulatory and pre-gonadotropin surge follicles. The ratio of estradiol:P4 which is often used was unreliable since P4 levels are high in atretic follicles and also in preovulatory post-gonadotropin follicles. We have therefore examined whether oxytocin (OT) levels in follicular fluids could enhance our ability to correctly and easily define follicular status. Based on E2 and OT concentrations in follicular fluids we could more accurately identify follicles that are preovulatory and post gonadotropin surge. Next we studied OT biosynthesis in granulosa cells, cells which were incubated with forskolin contained stores of the precursor indicating that forskolin (which mimics gonadotropin action) is an effective stimulator of OT biosynthesis and release. While studying in vitro luteinization, we noticed that IGF-I induced effects were not identical to those induced by insulin despite the fact that megadoses of insulin were used. This was the first indication that the cells may secrete IGF binding protein(s) which regonize IGFs and not insulin. In a detailed study involving several techniques, we characterized the species of IGF binding proteins secreted by luteal cells. The effects of exogenous polyunsaturated fatty acids and arachidonic acid on the production of P4 and prostanoids by dispersed bovine luteal cells was examined. The addition of eicosapentaenoic acid and arachidonic acid resulted in a dose-dependent reduction in basal and LH-stimulated biosynthesis of P4 and PGI2 and an increase in production of PGF 2a and 5-HETE production. Indomethacin, an inhibitor of arachidonic acid metabolism via the production of 5-HETE was unaffected. Results of these experiments suggest that the inhibitory effect of arachidonic acid on the biosynthesis of luteal P4 is due to either a direct action of arachidonic acid, or its conversion to 5-HETE via the lipoxgenase pathway of metabolism. The detailed and important information gained by the two labs elucidated the mode of action of factors crucially important to the function of the bovine CL. The data indicate that follicular granulosa cells make a major contribution to numbers of large luteal cells, OT and basal P4 production, as well as the content of cytochrome P450 scc. Granulosa-derived large luteal cells have distinct features: when luteinized, the cell no longer possesses LH receptors, its cAMP response is diminished yet P4 synthesis is sustained. This may imply that maintenance of P4 (even in the absence of a Luteotropic signal) during critical periods such as pregnancy recognition, is dependent on the proper luteinization and function of the large luteal cell.
Los estilos APA, Harvard, Vancouver, ISO, etc.
También puede estar interesado en las bibliografías ampliadas sobre el tema "Indomethacin" para tipos de fuentes particulares:
Artículos de revistas Tesis Libros
Ofrecemos descuentos en todos los planes premium para autores cuyas obras están incluidas en selecciones literarias temáticas. ¡Contáctenos para obtener un código promocional único!

Pasar a la bibliografía