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Literatura académica sobre el tema "Incremental lifetime cancer risk"

Autor: Grafiati

Publicado: 6 de septiembre de 2023

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Artículos de revistas sobre el tema "Incremental lifetime cancer risk"

Liu, Yunwei, Ning Qin, Weigang Liang, Xing Chen, Rong Hou, Yijin Kang, Qian Guo, Suzhen Cao y Xiaoli Duan. "Polycycl. Aromatic Hydrocarbon Exposure of Children in Typical Household Coal Combustion Environments: Seasonal Variations, Sources, and Carcinogenic Risks". International Journal of Environmental Research and Public Health 17, n.º 18 (8 de septiembre de 2020): 6520. http://dx.doi.org/10.3390/ijerph17186520.

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Polycyclic aromatic hydrocarbon (PAH) emissions from the combustion of household solid coal for cooking and heating cause great harm to public health in China, especially in less developed areas. Children are one of the most susceptible population groups at risk of indoor air pollutants due to their immature respiratory and immune systems. However, information on PAH exposure of children is limited due to limited monitoring data. In this study, we aimed to assess the seasonal differences of PAHs in classrooms, analyze the pollutant sources, and calculate the incremental lifetime cancer risk attributable to PAHs in Shanxi Provence. A typical school using household coal combustion in Shanxi Province was selected. Fine particulate matter (PM2.5)samples were collected by both individual samplers and fixed middle-flow samplers during the heating and non-heating seasons in December 2018 and April 2019. The PAH concentrations in PM2.5 samples were analyzed by a gas chromatograph coupled to a mass spectrometer. The results showed that PAH concentrations in PM2.5 varied between 89.1 ng/m3 in the heating season and 1.75 ng/m3 in the non-heating season. The mean concentrations of benzo[a]pyrene (BaP), a carcinogenic marker of PAHs, were 10.3 and 0.05 ng/m3 in the heating and non-heating seasons, respectively. Source allocation analysis of individual portable and passive samplers revealed that the main contributors during heating and non-heating seasons were coal combustion and gasoline sources, respectively. According to the results of a Monte Carlo simulation, the incremental lifetime cancer risk values from the inhalation of PAHs in the heating and non-heating seasons were 3.1 × 10−6 and 5.7 × 10−8, respectively. The significant increase in PAHs and the incremental lifetime cancer risk in the heating season indicates that children are more exposed to health threats in winter. Further PAH exposure control strategies, including reducing coal usage and promoting clean fuel applications, need to be developed to reduce the risk of PAH-induced cancer.

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Li, Chaocan, Xiaopeng Zhang, Xuqin Wang, Xinbo Zhang, Shigang Liu, Ting Yuan, Weigui Qu y Youjun Zhang. "Distribution Characteristics and Potential Risks of Polycyclic Aromatic Hydrocarbon (PAH) Pollution at a Typical Industrial Legacy Site in Tianjin, North China". Land 11, n.º 10 (15 de octubre de 2022): 1806. http://dx.doi.org/10.3390/land11101806.

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Polycyclic aromatic hydrocarbon (PAH) pollution in the soil of industrial legacy sites is a prominent problem when reusing urban land. To estimate the potential risks of PAHs, this study investigated 16 priority PAHs in the soil at different depths in a typical decommissioned industrial site in Tianjin. PAH concentrations were determined via gas chromatography-(tandem) quadrupole mass spectrometry. Incremental lifetime cancer risk (ILCR) assessment was applied to assess the potential risks to the population after land reconstruction. The total concentrations of PAHs in the soil at different depths ranged from 38.3 ng·g−1 to 1782.5 ng·g−1, which were below the risk control standard for soil contamination of development land (GB 36600-2018). Low-ring (two-three ring) PAHs exhibit a dominant component, and the variations in PAH compositions were closely related to the former production units and soil properties. Compared to silty clay layers, PAHs tended to accumulate in the permeable miscellaneous fill layers. Incremental lifetime cancer risk assessment values associated with different exposure pathways for children, adolescents, and adults were calculated. The results showed potential carcinogenic risks for people of varying ages in this area, but they were still acceptable. In general, this legacy site can meet the demands of sustainable land development.

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Tsoi, D. T., M. Inoue, C. M. Kelly, S. Verma y K. Pritchard. "Cost-effectiveness analysis of oncotype DX-guided treatment in early breast cancer". Journal of Clinical Oncology 27, n.º 15_suppl (20 de mayo de 2009): e11536-e11536. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11536.

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e11536 Background: Some early breast cancer patients with hormone receptor positive (HR+) disease may benefit from adjuvant chemotherapy in addition to hormonal therapy. Most guidelines recommend the addition of adjuvant chemotherapy for majority of women, leading to overtreatment causing considerable morbidity and cost. There has been recent incorporation of gene expression analysis to help aid in adjuvant chemotherapy decision making. We evaluated the cost-effectiveness of Oncotype DX-guided treatment as compared to treatment guided by Adjuvant! Online program. Methods: A Markov model was developed to compare the cost- effectiveness of treatment guided by either Oncotype DX or Adjuvant! Online in a cohort of 50-year-old women with HR+, lymph node negative breast cancer over a lifetime horizon. We assumed women assessed to be high risk all received chemotherapy followed by tamoxifen, and that those assessed to be low risk received tamoxifen only. The model took a health care payer's perspective with results reported in 2008 Canadian dollars ($). Event rates, costs and utilities were derived from the literature. Both costs and benefits were discounted at 5%. Sensitivity analysis for key parameters in the model was conducted. Outcome measures were life year gained, quality- adjusted life years (QALYs), lifetime costs, and incremental cost-effectiveness ratios (ICERs). Results: For a 50-year-old woman, Oncotype DX-guided treatment was associated with an incremental lifetime cost of $4,200 and a gain in 0.067 QALY, with an ICER of $61,800/QALY compared with treatment guided by Adjuvant! ICER was positively correlated to the cost of Oncotype DX and the age of patients. Results were most sensitive to probabilities relating to risk categorization and recurrence rate. Conclusions: Relative to Adjuvant!-guided treatment, Oncotype DX-guided treatment appears cost-effective with an ICER of $61,800/QALY from a Canadian health care perspective. [Table: see text]

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Zhang, Hui, Jia Jia Zhao, Ai Min Song y Ming Wei Song. "Health Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in the Pearl River Delta". Applied Mechanics and Materials 260-261 (diciembre de 2012): 631–36. http://dx.doi.org/10.4028/www.scientific.net/amm.260-261.631.

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The objective of this study was to quantify PAHs exposure level for different resident groups and to estimate the incremental lifetime cancer risk for people in the Pearl River Delta. A multimedia/multipathway exposure model recommended by USEPA was employed in this study. Results indicated that the average cancer risk of exposure to PAH16 was 2.63×10-5 a-1 and the loss of life expectancy was 163.48 minutes. Considering the large amounts of PAHs emitted into the ambient environment in China and the loss of life expectancy, it is extremely important to take a preliminary health risk assessment of citizens exposed to PAHs in the Pearl River Delta.

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Ehrhardt, Matthew J., Zachary J. Ward, Qi Liu, Aeysha Chaudhry, Anju Nohria, William Border, Joy M. Fulbright et al. "Cost-Effectiveness of the International Late Effects of Childhood Cancer Guideline Harmonization Group Screening Guidelines to Prevent Heart Failure in Survivors of Childhood Cancer". Journal of Clinical Oncology 38, n.º 33 (20 de noviembre de 2020): 3851–62. http://dx.doi.org/10.1200/jco.20.00418.

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PURPOSE Survivors of childhood cancer treated with anthracyclines and/or chest-directed radiation are at increased risk for heart failure (HF). The International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) recommends risk-based screening echocardiograms, but evidence supporting its frequency and cost-effectiveness is limited. PATIENTS AND METHODS Using the Childhood Cancer Survivor Study and St Jude Lifetime Cohort, we developed a microsimulation model of the clinical course of HF. We estimated long-term health outcomes and economic impact of screening according to IGHG-defined risk groups (low [doxorubicin-equivalent anthracycline dose of 1-99 mg/m2 and/or radiotherapy < 15 Gy], moderate [100 to < 250 mg/m2 or 15 to < 35 Gy], or high [≥ 250 mg/m2 or ≥ 35 Gy or both ≥ 100 mg/m2 and ≥ 15 Gy]). We compared 1-, 2-, 5-, and 10-year interval-based screening with no screening. Screening performance and treatment effectiveness were estimated based on published studies. Costs and quality-of-life weights were based on national averages and published reports. Outcomes included lifetime HF risk, quality-adjusted life-years (QALYs), lifetime costs, and incremental cost-effectiveness ratios (ICERs). Strategies with ICERs < $100,000 per QALY gained were considered cost-effective. RESULTS Among the IGHG risk groups, cumulative lifetime risks of HF without screening were 36.7% (high risk), 24.7% (moderate risk), and 16.9% (low risk). Routine screening reduced this risk by 4% to 11%, depending on frequency. Screening every 2, 5, and 10 years was cost-effective for high-risk survivors, and every 5 and 10 years for moderate-risk survivors. In contrast, ICERs were > $175,000 per QALY gained for all strategies for low-risk survivors, representing approximately 40% of those for whom screening is currently recommended. CONCLUSION Our findings suggest that refinement of recommended screening strategies for IGHG high- and low-risk survivors is needed, including careful reconsideration of discontinuing asymptomatic left ventricular dysfunction and HF screening in low-risk survivors.

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Ehrhardt, Matthew J., Zachary J. Ward, Qi Liu, Aeysha Chaudhry, Anju Nohria, William L. Border, Leslie L. Robison et al. "Cost-effectiveness of screening guidelines to prevent heart failure in childhood cancer survivors: A report from the Childhood Cancer Survivor Study (CCSS)." Journal of Clinical Oncology 37, n.º 15_suppl (20 de mayo de 2019): 10052. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.10052.

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10052 Background: Childhood cancer survivors treated with anthracyclines or chest radiation therapy (RT) are at risk for left ventricular dysfunction (LVD) and subsequent heart failure (HF). The International Guideline Harmonization Group (IGHG) recommends risk-based screening echocardiograms for LVD, but evidence supporting its frequency and cost-effectiveness is limited. Methods: Using data from the CCSS, we developed a microsimulation model of the clinical course of LVD and HF to estimate long-term health and economic outcomes associated with screening for IGHG-defined risk groups (low [anthracycline 1-99 mg/m2 and/or RT < 15 Gy], moderate [100 to < 250 mg/m2 or 15 to < 35 Gy], high [≥ 250 mg/m2 or ≥ 35 Gy or (≥ 100 mg/m2 and ≥ 15 Gy)]). We compared 1, 2, and 5-year interval-based screening to no screening. Screening performance and pharmacological treatment effectiveness were based on published studies. Costs and quality of life weights were based on US averages and published studies. Outcomes included lifetime HF risk, quality-adjusted life years (QALYs), lifetime costs, and incremental cost-effectiveness ratios (ICERs). Strategies with ICERs < $100,000/QALY gained were considered cost-effective. Results: Among the IGHG risk groups, the lifetime HF risk in the absence of screening was 37% (high), 25% (moderate) and 17% (low). Screening every 2 or 5 years was cost-effective for the high-risk group, and every 5 years for the moderate-risk group. In contrast, routine screening may not be cost-effective for the low risk group, representing ~40% of those for whom screening is currently recommended. Conclusions: Our findings can inform screening guidelines and suggest that LVD/HF surveillance for low-risk survivors warrants careful consideration. [Table: see text]

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Bamuwamye, Michael, Patrick Ogwok, Vivian Tumuhairwe, Richard Eragu, Henriettah Nakisozi y Patrick Engeu Ogwang. "Human Health Risk Assessment of Heavy Metals in Kampala (Uganda) Drinking Water". Journal of Food Research 6, n.º 4 (3 de junio de 2017): 6. http://dx.doi.org/10.5539/jfr.v6n4p6.

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Levels of aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc in tap water, groundwater-fed protected spring and bottled water were determined. The cancer and non-cancer risks associated with ingestion of heavy metals (HM) were also assessed for both children and adults. Forty seven water samples obtained from five divisions of Kampala city were analyzed using atomic absorption spectrophotometry. Cancer and non-cancer risks were determined using incremental lifetime cancer risk (ILCR) and non-carcinogenic hazard quotient (HQ), respectively. Lead content was higher than permissible limits (PL) according to East African Standard, World Health Organization, European Union and United States Environmental Protection Agency (USEPA). Arsenic showed minor exceedances above guideline values in tap water and groundwater-fed protected spring, whereas mercury, manganese and nickel were higher than PL. Levels of aluminium, cadmium, chromium, copper, iron, and zinc were below the PL. The lifetime risk of developing cancer through the oral route was greater than the USEPA acceptable level for both children and adults, revealing that exposure to HM in drinking water posed an unacceptable potential cancer risk. Arsenic contributed ca. 90% of the ILCR in tap water and groundwater-fed protected spring. The combined non-cancer risk of the HM expressed as hazard index (HI) was greater than one, with values for children being higher than those for adults. Lead contribution towards HI was in all cases above 90%. These results demonstrate the presence of alarming non-cancer risks for children.

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Hillner, B. E., J. M. Kirkwood, M. B. Atkins, E. R. Johnson y T. J. Smith. "Economic analysis of adjuvant interferon alfa-2b in high-risk melanoma based on projections from Eastern Cooperative Oncology Group 1684." Journal of Clinical Oncology 15, n.º 6 (junio de 1997): 2351–58. http://dx.doi.org/10.1200/jco.1997.15.6.2351.

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PURPOSE Interferon alfa-2b (IFN) in a randomized clinical trial (E1684) prolonged relapse-free and total survival in high-risk resected melanoma. However, the costs and toxicities of IFN are barriers to its widespread use. This study was undertaken to analyze the projected costs and long-term benefits of IFN by combining prospectively collected data on IFN actual dosage, time of recurrence, and survival with secondary data on long-term melanoma recurrence risks to project the cost-effectiveness of adjuvant IFN compared with observation. PATIENTS AND METHODS Two hypothetical cohorts of 50-year-old melanoma patients whose mean IFN dosage and clinical results were directly taken from E1684 were included in the study. Melanoma recurrence risks beyond 5 years were derived from international databases. Melanoma recurrence care costs and quality-of-life adjustments, when considered, were based on expert consensus. End points were incremental costs, life-years gained, and cost per life-year gained with and without quality-of-life adjustments. RESULTS The IFN cohort was projected to have an increased (undiscounted) survival of 0.52 years at 7 years and 1.90 years over a lifetime. The projected incremental cost (in 1996 United States dollars) per life-year gained in the IFN cohort ranged from $13,700 after 35 years to $32,600 at 7 years, the median follow-up of E1684. Using assigned quality-of-life values for IFN and recurrence, the lifetime cost per quality adjusted life-year increased to $15,200. Even if treatment costs for recurrence were excluded, the lifetime incremental cost per life-year gained was $21,600. CONCLUSION The cost and toxicity of IFN must be balanced against its projected benefits in high-risk melanoma. The derived cost-effectiveness and cost-utility ratios for IFN were comparable to other cancer interventions for which cost-effectiveness analysis has been performed.

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Room, Shahzada Amani, Chia En Lin, Shih Yu Pan, Ta Chih Hsiao, Charles C. K. Chou y Kai Hsien Chi. "Incremental Lifetime Cancer Risk of PAHs in PM2.5 via Local Emissions and Long-Range Transport during Winter". Aerosol and Air Quality Research 23 (2023): 220319. http://dx.doi.org/10.4209/aaqr.220319.

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Bamuwamye, Michael, Patrick Ogwok, Vivian Tumuhairwe, Richard Eragu, Henriettah Nakisozi y Patrick E. Ogwang. "Dietary Content and Potential Health Risks of Metals in Commercial Black Tea in Kampala (Uganda)". Journal of Food Research 6, n.º 6 (23 de septiembre de 2017): 1. http://dx.doi.org/10.5539/jfr.v6n6p1.

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Tea (Camellia sinensis (L.) Kuntze) is among the most widely consumed non-alcoholic beverages. It is a rich source of essential dietary elements mainly potassium and manganese. Tea may also contain toxic metals such as cadmium and lead which pose a threat to human health because of their toxicity. Twenty samples of commercial black tea in Kampala city were randomly obtained and analysed for potassium, sodium, aluminium, arsenic, cadmium, chromium, copper, iron, mercury, manganese, nickel, lead and zinc using Atomic Absorption Spectrophotometry. Human health risks due to exposure to toxic elements from daily consumption of tea were determined using incremental lifetime cancer risk and non-cancer hazard quotient. Metal contents of black tea sold in Kampala were below international regulatory limits. The estimated daily intake of the elements in two grams of black tea was below the recommended values. Hazard quotient and hazard index were within acceptable range. Total cancer risk levels for all the teas were also within United States Environmental Protection Agency (USEPA) acceptable range. Daily consumption of one cup containing two grams of black tea over a lifetime will promote consumer overall health and wellbeing.

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Tesis sobre el tema "Incremental lifetime cancer risk"

Wilson, Jodi. "Lifetime Physical Activity and the Risk of Colorectal Cancer: A Population-Based Case-Control Study Using Data from the Newfoundland Colorectal Cancer Registry". Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34537.

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Although there is consistent evidence of an inverse association between physical activity and colorectal cancer (CRC), it is unclear whether physical activity has to be lifelong in order to protect against CRC, or whether there are critical time periods in which physical activity is most protective. This thesis investigated the association between recreational physical activities in specific age periods and across the lifetime and CRC risk in data from a population-based case control study (n=1395) in Newfoundland and Labrador. There were no significant associations between recreational physical activity at any age period or across the lifetime. Lack of association with activity in early adulthood is consistent with other studies in which this has been investigated. Lack of association in later life and across the lifetime may in part be explained by low levels of recreational physical activity, with only 30% of participants meeting World Cancer Research Fund cancer prevention recommendations.

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Levy, Adrian R. 1962. "Projecting the lifetime risk of breast and thyroid cancer from exposure to diagnostic ionizing radiation for adolescent idiopathic scoliosis". Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61333.

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The purpose of this study was to determine the cumulative doses of x-ray radiation to the thyroid gland and female breast from spinal radiographs for Adolescent idiopathic scoliosis (AIS) and to estimate the number of cancers at these sites attributable to x-rays.
Subjects for this study were patients referred from 1960 to 1979 for AIS to Hopital Ste-Justine, Montreal.
About 85 percent of 2,181 subjects were first referred for scoliosis between the ages of eleven and seventeen and the average time under observation was about three years. The mean number of radiographs was about twelve. The mean cumulative dose to the thyroid gland and to the female breast was about three cGy. Seven excess breast cancer and thyroid cancer cases were projected to occur over the lifetime of the women; among these, two excess deaths from cancers were projected. Approximately one in every 250 women in this cohort would be expected to develop breast or thyroid cancer over their lifetime, and one in every 900 women would be expected to develop a fatal cancer. (Abstract shortened by UMI.)

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Irvine, Graham. "Soil Ingestion Rate and Excess Lifetime Cancer Risk in First Nations’ People Exposed to Polycyclic Aromatic Hydrocarbons Near In-situ Bitumen Extraction in Cold Lake, Alberta". Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26088.

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The inadvertent ingestion of contaminated soil is the dominant exposure route of non-volatile and semi-volatile contaminants such as polycyclic aromatic hydrocarbons (PAHs). Quantitative mass balance soil ingestion studies have been used to determine soil ingestion rates for use in human health risk assessments (HHRA) that can be used to predict the likelihood of adverse effects in individuals exposed to hazardous contaminants such as PAHs in contaminated soil. The Cold Lake region of Alberta is one of the three major oil sands regions of Alberta, and PAH concentrations in this oil sand region may be elevated in the atmosphere and the soil, resulting in increased exposures to PAHs. The area is home to Cold Lake First Nation who practice traditional activities and lifestyles that may put them in greater contact with soil than previous soil ingestion studies suggest. The primary objective of this research was to assess the soil ingestion rate in a group of First Nations subjects inhabiting the Cold lake region, and assess the carcinogenic risk posed by exposures to PAHs in air and soil. The study employed a quantitative mass balance tracer approach to estimate soil ingestion rates, and followed 9 subjects over a 13 day period. Soil and air samples were simultaneously collected to assess PAH contamination. The mean soil ingestion rate using Al and Si elemental tracers was 52 mg d-1, with a 90th percentile of 220 mg d-1, and a median soil ingestion rate of 37 mg d-1. These values are greater than the soil ingestion rates for HHRA recommended by Health Canada. The mean increase in excess lifetime cancer risk posed by inadvertent ingestion of soil to a First Nations’ individuals following traditional activities was 0.02 cases per 100,000 people with a 95% risk level of 0.067 cases per 100,000 people. Exposure to PAHs through inhalation posed a maximum lifetime cancer risk below 0.1 cases per 100,000, people. Thus, this study found no appreciable increase in excess lifetime associated with PAH exposure of First Nations’ people in the Cold Lake region.

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Mahamat, Saleh Yahya. "Etude des associations entre facteurs nutritionnels et risque de cancers cutanés dans les cohortes E3N et EPIC Citrus Intake and Risk of Skin Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis Circulating 25-Hydroxyvitamin D Level, Vitamin D Intake, and Risk of Skin Cancers: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies Mediterranean Dietary Pattern and Skin Cancer Risk: A Prospective Cohort Study in French Women. Am JClin Nutr Antioxidant Supplement Use and Risk of Keratinocytes Cancers: A Prospective Cohort Study Baseline and Lifetime Alcohol Consumption and Risk of Skin Cancer in the European Prospective Investigation into Cancer and nutrition cohort (EPIC)". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASR008.

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Titre : Etude des associations entre facteurs nutritionnels et risque de cancers cutanés dans les cohortes E3N et EPICLes cancers cutanés sont les néoplasmes les plus fréquents chez les populations de type Caucasien et leur incidence est en constante augmentation. L'exposition aux rayonnements ultraviolets (UV) est le seul facteur environnemental reconnu comme cause avérée de cancer de la peau et actuellement le seul pour lequel une prévention est possible. Cependant, il apparait de plus en plus probable que certains facteurs nutritionnels, notamment les antioxydants, pourraient empêcher les effets néfastes de l'exposition aux UV et ainsi potentiellement représenter des agents de chimio-prévention des cancers cutanés. Il a également été suggéré que certains groupes d'aliments, tels que les agrumes, les compléments alimentaires, les acides gras, la vitamine D et l'alcool pouvaient être associés à un risque accru de cancers cutanés. Cependant, les études menées jusqu'à présent n'ont pas permis d'émettre de conclusion claire : peu d'études prospectives avec un échantillon suffisamment important et disposant de données sur l'exposition solaire sont disponibles. Il est donc nécessaire de faire progresser nos connaissances dans ce domaine afin de mieux cibler les campagnes de prévention des cancers cutanés.L’objectif principal de cette thèse était d’explorer les relations entre les facteurs nutritionnels et le risque de cancers cutanés. Les données utilisées dans ce projet incluent les données de la cohorte E3N, incluant près de 100 000 femmes françaises suivies depuis 1990, les données de la cohorte EPIC, incluant près de 520 000 participants issus de 10 pays européens, et les données du PMP, une étude prospective incluant 700 patients australiens atteints de mélanome suivis depuis 2014. De plus, les données de la littérature sur les liens entre vitamine D et mélanome ont été résumées et poolées dans une revue systématique et une méta-analyse.Nos résultats suggèrent que l’adhérence au régime méditerranéen est associée à risque plus faible de cancers cutanés, plus particulièrement de mélanome et de carcinome baso-cellulaire ; en revanche la prise de compléments alimentaires en bêta-carotène, vitamine A ou E était associée à un risque accru de carcinomes cutanés. De plus, nous avons observé que les consommations d’agrumes ou d’alcool étaient associées à un risque plus élevé de cancers cutanés. Par ailleurs, nos résultats suggèrent qu’une forte consommation d’un régime « riche en viande, poisson et graisses » est associée à l’épaisseur du mélanome. Enfin, les résultats de notre méta-analyse suggèrent que les taux circulants élevés de vitamine D sont associés à un risque accru de mélanome et de carcinomes cutanés.Les travaux de cette thèse ont mis en lumière des relations complexes entre les facteurs nutritionnels et le risque de cancers cutanés. Par ailleurs, ils soulèvent plusieurs questions qu’il serait envisageable d’approfondir dans d’autres études. Si ces résultats sont répliqués, ils pourraient, à terme, avoir un impact sur les stratégies de prévention des cancers cutanés.Mots-clés : cancers cutanés ; régime méditerranéen ; compléments en antioxydants ; agrumes ; alcool ; profils alimentaires ; vitamine D ; cohorte prospective ; méta-analyse
Title: Associations between nutritional factors and skin cancer risk in the E3N and EPIC cohortsSkin cancers are the most frequent neoplasms in Caucasian populations and their incidence has been constantly rising. Ultraviolet (UV) radiation exposure is the only environmental risk factor recognized as a cause of skin cancer and the only factor for which prevention is possible. However, it appears increasingly likely that several nutritional factors, particularly antioxidants, could counteract the negative effects of UV exposure and thus potentially represent chemo-preventive agents for skin cancer. It has also been suggested that several food groups, such as citrus, dietary supplements, vitamin D, fatty acids, and alcohol, could be associated with skin cancer risk. However, investigations to date did not allow to draw clear conclusions; few prospective data are indeed available within a sufficiently large sample and available sun exposure data. It is thus crucial to advance our knowledge in this field in order to target skin cancer prevention campaigns more precisely.The objective of this doctoral project was to study the relationships between nutritional factors and skin cancer risk. To achieve our objective, we used data from E3N, a prospective cohort of ~ 100,000 French women followed since 1990, data from EPIC cohort, a prospective cohort involving ~520,000 participants who have been followed-up in 23 centers from 10 European countries, and data from PMP, a prospective study of ~700 melanoma patients diagnosed in Queensland between 2010 and 2014. Additionally, data from the literature were summarized and pooled in a systematic review and meta-analysis.Our results suggest that adherence to the Mediterranean diet is associated with a lower skin cancer risk in women, particularly melanoma and basal-cell carcinoma. Intake of supplements in beta-carotene, vitamin A or E was associated with an increased keratinocyte cancer risk in women. In addition, we found positive linear relationships between citrus intake and skin cancer risk, which were mostly driven by associations with keratinocyte cancers, and between alcohol consumption and overall skin cancer risk. However, our results also suggest that people with high meat, fish, and fat intakes, who thus consumed relatively high levels of omega-3 and high omega-6 fatty acid intakes, are more likely to be diagnosed with thick than thin melanomas. In the meta-analysis, we found positive associations between serum 25(OH)D levels and melanoma and keratinocyte cancer risk.This project highlighted complex relationships between nutritional factors and the risk of skin cancers. It also raised several questions that could be considered for further study. If replicated and confirmed in future research, these findings may ultimately have important implications in skin cancer prevention.Keyword: skin cancer ; Mediterranean diet ; antioxidant supplements ; citrus ; alcohol ; dietary pattern; vitamin D; prospective cohort; meta-analysis

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Ciappuccini, Renaud. "Apport de l'imagerie fonctionnelle par TEMP/TDM et TEP/TDM dans la prise en charge des cancers différenciés de la thyroïde Incremental Value of a Dedicated Head and Neck Acquisition during 18F-FDG PET/CT in Patients with Differentiated Thyroid Cancer Full text links full-text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles Cited by References Related information LinkOut - more resources EJNMMI Res . 2018 Dec 3;8(1):104. doi: 10.1186/s13550-018-0461-x. Optimization of a dedicated protocol using a small-voxel PSF reconstruction for head-and-neck 18 FDG PET/CT imaging in differentiated thyroid cancer 78 Lymph node involvement in head-and-neck and thyroid cancers with digital PET/CT: the impact of ultra-high definition voxels and point-spread function Tumor burden of persistent disease in patients with differentiated thyroid cancer: correlation with postoperative risk-stratification and impact on outcome 133 18F-Fluorocholine PET/CT is a highly sensitive but poorly specific tool for identifying malignancy in thyroid nodules with indeterminate cytology: The Chocolate study PSMA expression in neovasculature of persistent/recurrent differentiated thyroid cancerin the neck: relationship with radioiodine uptake, 18Fluorodeoxyglucose avidity and outcome". Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC424.

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L’imagerie scintigraphique des cancers thyroïdiens différenciés (CTD) présente la particularité d’utiliser deux radiopharmaceutiques, l’iode 131 (131I) et le 18-Fluorodésoxyglucose (18FDG). La fixation de ces traceurs dépend habituellement du degré de différenciation et de l’agressivité de la tumeur. L’objectif de ce travail était d’étudier l’apport de différents aspects techniques et d’instrumentation, à savoir l’imagerie hybride par TEMP/TDM et TEP/TDM, la point-spread function (PSF), la taille des voxels et la technologie TEP digitale, et d’explorer si d’autres traceurs TEP pouvaient présenter un intérêt. Le but de la première partie était d’étudier les performances de la TEP/TDM au 18FDG à l’étage cervical pour la détection de la maladie ganglionnaire. Une acquisition TEP/TDM dédiée a amélioré la détection de la maladie tumorale par rapport à l’acquisition classique. L’utilisation de la PSF a permis de détecter des tailles de lésions plus petites et la durée optimale de cette acquisition a été évaluée. Des reconstructions avec des tailles de voxels ultra-fines ont été réalisées sur TEP digitale pour étudier l’impact de la PSF et des voxels ultra-fins sur les données quantitatives. La seconde partie a porté sur l’imagerie 131I-TEMP/TDM et 18FDG-TEP/TDM, afin de quantifier le volume de la maladie persistante. Il a ainsi été montré que la masse tumorale était corrélée au risque post-opératoire et avait un impact sur la réponse au traitement. L’objectif de la troisième partie était d’étudier un autre traceur TEP, la 18-Fluorocholine (FCH), ainsi qu’un marqueur de la néovascularisation, l’antigène membranaire spécifique de la prostate (PSMA). Nos données suggèrent qu’un examen TEP à la FCH négatif au sein d’un nodule thyroïdien à cytologie indéterminée permettrait d’éliminer la malignité, et pourrait éviter des chirurgies inutiles. Par ailleurs, le marquage au PSMA évalué par immunohistochimie dans les néo-vaisseaux est associé à des facteurs de mauvais pronostic. D’autres études sont nécessaires pour confirmer l’intérêt éventuel des examens TEP à la FCH et au 68Ga-PSMA en oncologie thyroïdienne
Radioiodine (131I) and 18-Fluorodeoxyglucose (18FDG) are two radiopharmaceuticals used for scintigraphic imaging in differentiated thyroid cancers (DTC). Tumour uptake of each tracer depends on tumour differentiation and aggressiveness. Our goal was to further assess various technical aspects in DTC imaging workup, such as SPECT/CT and PET/CT, point-spread function (PSF), voxel size, digital PET, and to explore further other PET tracers. The aim of the first part was to assess the performance of 18FDG PET/CT for the detection of neck lymph node involvement. A dedicated PET/CT acquisition improved tumour detection compared to the whole-body acquisition. PSF reconstruction allowed detection of smaller cancer deposits and the optimal acquisition duration time was assessed. Using digital PET acquisitions, ultra-thin voxels reconstructions were performed. The impact of ultra-thin voxels and PSF on quantitative values was evaluated. The second part focused on 131I-SPECT/CT and 18FDG-PET/CT imaging, in an attempt to assess tumour burden of persistent disease. Tumor burden was correlated with the postoperative risk and affected the response to therapy. In the third part, another PET tracer, i.e. 18-Fluorocholine (FCH), and a marker of neovasculature, i.e. prostate-specific membrane antigen (PSMA), were studied. FCH PET/CT offered high negative predictive value to reliably exclude cancer in PET-negative nodules with indeterminate cytology and might prevent unnecessary surgeries. Also, PSMA expression assessed with immunohistochemistry was associated with poor prognosis factors. Further studies are needed to confirm new insights of FCH PET and 68Ga-PSMA PET in DTC

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Srivastava, Pooja. "Monitoring and risk assessment of polyaromatic hydocarbons (PAHs) in a stretch of river ganges". Thesis, 2016. http://localhost:8080/iit/handle/2074/7104.

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Cheasley, Roslyn. "Geographic exposure and risk assessment for food contaminants in Canada". Thesis, 2016. http://hdl.handle.net/1828/7396.

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The purpose of this thesis is to explore differences in lifetime excess cancer risk (LECR) for Canadians from intake of contaminants in food and beverages based on geographic location, gender and income levels. A probabilistic risk assessment approach (Monte Carlo simulation) was used to estimate the range and frequency of possible daily contaminant intakes for Canadians, and associate these intake levels with lifetime excess cancer risk. Monte Carlo risk simulation was applied to estimate probable contaminant intake and associated lifetime excess cancer risk from arsenic, benzene, lead, polychlorinated biphenyls (PCBs) and tetrachloroethylene (PERC) in 60 whole foods from the dietary patterns of 34,944 Canadians from 10 provinces, as derived from Health Canada’s Canadian Community Health Survey, Cycle 2.2, Nutrition (2004)1. These results were compared to the current Health Canada guideline that suggests that 10 extra cancers per one million people is a negligible risk. Of the 5 contaminants tested in my model arsenic showed the greatest difference between urban and rural estimated lifetime excess cancer risk, although extra cancers in both rural and urban Canada were predicted from exposure to PCB and benzene. Lifetime excess cancer risk is estimated to be higher for men in Canada for all five contaminants, with an emphasis on males in British Columbia compared to females from the dietary intake of arsenic. When based on income level, my model predicts extra cancers higher for low and middle incomes from dietary exposures to arsenic, benzene, lead and PERC, however, high income populations are more likely to have extra cancers from dietary intake of PCBs.
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L'Espérance, Kevin. "La consommation d'alcool à vie et le risque de cancer épithélial de l'ovaire". Thèse, 2019. http://hdl.handle.net/1866/23578.

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Contexte: Le cancer de l'ovaire est le cancer gynécologique le plus meurtrier chez les Canadiennes. Compte tenu de son mauvais pronostic et de ses méthodes de dépistage précoce limitées, il est nécessaire de mener des recherches pour identifier les facteurs susceptibles d'empêcher le cancer de l'ovaire de se développer. L’alcool est un facteur de risque pour de nombreux cancers, mais sa relation avec le cancer de l’ovaire demeure floue. Nous avons décidé d’étudier la relation entre la consommation d'alcool au cours de la vie et le risque de cancer de l'ovaire. Méthodes: Dans une étude cas-témoins basée sur la population à Montréal (2011-2016), 497 cas et 904 témoins ont rapporté leur consommation au cours de leur vie de vin rouge, de vin blanc, de bière et de spiritueux, ainsi que d'autres variables. Pour la consommation totale d'alcool et pour chaque type d'alcool spécifique, les rapports de cotes ajustés (OR) et les intervalles de confiance (IC) à 95% pour l'association avec le risque de cancer de l'ovaire ont été estimés à l'aide de la régression logistique inconditionnelle. Résultats: Le lien entre la consommation totale d'alcool au cours de la vie et le risque de cancer de l'ovaire explicitait une relation en forme de U: comparées à celles qui n'ont jamais bu, l’OR (IC à 95%) était de 0,72 (0,52-0,99) pour les participantes qui buvaient >0 à <1 consommation par semaine, de 0,83 (0,61-1,15) pour 1 à <3 consommations/semaine et de 0,98 (0,72-1,33) pour ³3 consommations/semaine. Une relation en forme de U a été suggérée pour la consommation de bière et de spiritueux au cours de la vie, mais les OR étaient plus proches de la valeur nulle. Les analyses par comportement tumoral ont suggéré que la consommation totale d'alcool au cours de la vie était associée à un risque réduit de cancer de l'ovaire invasif, mais à un risque accru de cancer de l'ovaire limite. Une tendance similaire a été observée pour la consommation de bière, mais pas pour les spiritueux, le vin rouge ou le vin blanc. Conclusion: La consommation d'alcool pourrait être associée de manière non linéaire au cancer de l'ovaire et cette association pourrait varier en fonction du comportement tumoral.
Background: Ovarian cancer is the deadliest gynecological cancer among Canadian women. Given its poor prognosis and limited methods of early detection, research is necessary to identify factors that may prevent ovarian cancer from occurring in the first place. Alcohol is a risk factor for many cancer sites, but its relationship with ovarian cancer remains unclear. We investigated the relation between lifetime alcohol consumption and ovarian cancer risk. Methods: In a population-based case-control study in Montreal (2011-2016), 497 cases and 904 controls reported their lifetime consumption of red wine, white wine, beer and spirits and other variables. For total alcohol intake and each specific alcohol type, adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association with ovarian cancer risk were estimated using unconditional logistic regression. Results: The association between lifetime total alcohol intake and ovarian cancer risk was U-shaped: compared to lifetime never drinkers, the OR (95% CI) was 0.72 (0.52-0.99) for drinking >0 to <1 drink/week, 0.83 (0.61-1.15) for 1-<3 drinks/week and 0.98 (0.72-1.33) for 3+ drinks/week. A Ushaped relationship was suggested with lifetime consumption of beer and spirits but ORs were nearer the null value. Analyses by tumour behaviour suggested that lifetime total alcohol intake was associated with a reduced risk of invasive ovarian cancer but an increased risk of borderline ovarian cancer. A similar pattern was observed for intake of beer, but not spirits, red or white wine. Conclusion: Alcohol consumption may be non-linearly associated with ovarian cancer and the association may vary by tumour behaviour.

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Libros sobre el tema "Incremental lifetime cancer risk"

Rood, Arthur S. Estimated exposure and lifetime cancer incidence risk from routine plutonium releases at the Rocky Flats Plant: Part of task 3, independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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Rood, Arthur S. Estimated exposure and lifetime cancer incidence risk from 903 area plutonium releases at the Rocky Flats Plant: Part of task 3, independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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McGavran, Patricia D. Estimated exposure and lifetime cancer incidence risk from beryllium released to the air from the Rocky Flats Plant: Part of task 3, independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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Rood, Arthur S. Comprehensive assessment of exposure and lifetime cancer incidence risk from plutonium released from the Rocky Flats Plant, 1953-1989: Part of task 3, Independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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Rood, Arthur S. Estimated exposure and lifetime cancer incidence risk from plutonium releases from the 1957 fire at the Rocky Flats Plant: Part task 3, independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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Rood, Arthur S. Estimated exposure and lifetime cancer incidence risk from plutonium releases from the 1969 fire at the Rocky Flats Plant: Part of task 3, independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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McGavran, Patricia D. Estimated exposure and lifetime cancer incidence risk from carbon tetrachloride released to the air from the Rocky Flats plant: Part of task 3, independent analysis of exposure, dose, and health risk to offsite individuals. Neeses, S.C: Radiological Assessments Corporation, 1999.

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Lee, Christoph I. Cancer Risk from Pediatric CT. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190223700.003.0048.

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This chapter, found in the radiation exposure from medical imaging section of the book, provides a succinct synopsis of a key study estimating the potential radiation-induced cancer risk to pediatric patients undergoing computed tomography scans. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. The study demonstrated that pediatric patients are at significantly increased lifetime radiation risks from CT compared to adults, and that every effort should be made to eliminate unnecessary radiation exposure among them. In addition to outlining the most salient features of the study, a clinical vignette is included in order to provide relevant clinical context.

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Plutynski, Anya. Safe or Sorry? Cancer Screening and Inductive Risk. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190467715.003.0008.

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The general assumption behind cancer screening has been that early diagnosis and treatment is effective at reducing cancer-related mortality; this is broadly speaking true, for some cancer screening efforts, in some age groups. However, screening may in some cases do more harm than good. One source of harm is overdiagnosis and overtreatment, the diagnosis and treatment of indolent or slow-growing disease that may never lead to morbidity or mortality in the lifetime of the patient. Precaution in cancer screening is thus a double-edged sword: early diagnosis and treatment has clear benefits; but it is also true that some percentage of patients is unnecessarily treated. This chapter will examine how inductive risk and values come into play in debates about mammography screening.

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Ajzensztejn, Daniel. Prostate cancer. Editado por Patrick Davey y David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0326.

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Prostate cancer is the commonest male malignancy, with approximately 35 000 new cases in the UK annually, equating to a lifetime risk of 1 in 10. When diagnosed early, it has a high chance of cure with surgery, external beam radiotherapy, or brachytherapy. Even for metastatic disease, the prognosis is usually several years.

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Capítulos de libros sobre el tema "Incremental lifetime cancer risk"

Jovanovic, Rastko y Marija Zivkovic. "Probabilistic Simulation of Incremental Lifetime Cancer Risk of Children and Adults Exposed to the Polycyclic Aromatic Hydrocarbons – PAHs in Primary School Environment in Serbia, Model Development and Validation". En Computational and Experimental Approaches in Materials Science and Engineering, 203–20. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-30853-7_12.

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Freni, Stan C. "Application of Estimated Excess Lifetime Cancer Risk in Field Situations". En Uncertainty in Risk Assessment, Risk Management, and Decision Making, 339–47. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5317-1_27.

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Tilanus-Linthorst, Madeleine M. A. y Emiel J. T. Rutgers. "Breast Cancer Screening with MRI in Women with Over 20% Lifetime Risk". En Screening and Risk Reduction Strategies for Breast Cancer, 77–83. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7630-8_5.

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Halid, B., M. K. A. Karim, A. Sabarudin, K. A. Bakar y N. D. Shariff. "Assessment of Lifetime Attributable Risk of Stomach and Colon Cancer During Abdominal CT Examinations Based on Monte Carlo Simulation". En 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6), 455–59. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4361-1_77.

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Thélin, Camille y Sanjay Sikka. "Epidemiology of Colorectal Cancer — Incidence, Lifetime Risk Factors Statistics and Temporal Trends". En Screening for Colorectal Cancer with Colonoscopy. InTech, 2015. http://dx.doi.org/10.5772/61945.

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Wittich, Michelle A. Neben y Katharine A. Price. "Lung Cancer and Head and Neck Cancer". En Mayo Clinic Internal Medicine Board Review, 683–88. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190464868.003.0065.

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Approximately 233,000 new cases of prostate cancer occur annually in the United States. It is the most common cancer in US men and is the second leading cause of death from cancer in US men (29,000 deaths annually). Risk factors for prostate cancer include older age, race (African American), family history (first-degree relative), and possibly dietary fat. The lifetime probability of prostate cancer developing in a man is 1 in 6.

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Weitz, Jürgen, Markus W. Büchler, Paul D. Sykes, John P. Neoptolemos, Eithne Costello, Christopher M. Halloran, Frank Bergmann et al. "Pancreatic cancer". En Oxford Textbook of Oncology, 478–507. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0040.

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Pancreatic cancer comprises of several different exocrine and endocrine malignant diseases. The most common form is pancreatic adenocarcinoma, the tenth most common solid cancer in most of Western countries, which is discussed in this chapter. The lifetime risk of developing such a disease is 1.5%, with a mean age of diagnosis in the seventh decade. Unfortunately, no specific symptoms of this disease exist. Typically, patients present with unspecific abdominal discomfort, weight loss, and early satiety. More specific symptoms are painless jaundice and signs of endocrine or exocrine pancreatic insufficiency. Management of pancreatic cancer is complex and should best be performed by a multidisciplinary team. The individual components of such an approach are described in this chapter.

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Weitz, Jürgen, Markus W. Büchler, Paul D. Sykes, John P. Neoptolemos, Eithne Costello, Christopher M. Halloran, Thilo Hackert et al. "Pancreatic cancer". En Oxford Textbook of Oncology, 478–507. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0040_update_001.

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Dahm, Philipp. "Early Detection of Prostate Cancer". En 50 Studies Every Urologist Should Know, 1–6. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190655341.003.0001.

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This chapter describes the design, main findings, relevance, and limitations of the European Randomized Study of Screening for Prostate Cancer (ERSPC), which compared screening based on prostate-specific antigen (PSA) to no screening. ERSPC indicated that screened patients may derive a small survival benefit in terms of prostate cancer–specific mortality but not all-cause mortality. Such a benefit is most likely realized in men with an extended life expectancy of 15 years or greater. The potential harms of PSA-based prostate cancer screening include a high rate of false-positive tests, biopsy-related complications, the unnecessary diagnosis of low-risk prostate cancer unlikely to affect a man during his lifetime (overdiagnosis) in some, and treatment sequelae both in men who may benefit from treatment and those who will not (overtreatment).

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Schmidt, Marjanka K., Alexandra J. van den Broek, Mark E. Robson, Ornella Campanella, Soo Hwang Teo, Irene L. Andrulis, Eveline M. Bleiker y Fred H. Menko. "Genetics". En Breast cancer: Global quality care, editado por Hans Junkermann, Wolfgang Buchberger, Sylvia Heywang-Köbrunner, Michael Michell, Alexander Mundinger, Carol Benn y Sophia Zackrisson, 234–50. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198839248.003.0021.

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Abstract: About 10–30% of breast cancers are estimated to be explained by known (mostly modifiable) lifestyle and environmental factors; this is population dependent. Another 20–30% of breast cancers can be explained by germline genetics. For women with pathogenic BRCA1 and BRCA2 mutations, the risk of developing breast cancer is estimated to be between 27% and 80% by age 70 years, compared to a 4–12% lifetime risk for the general female population worldwide. Pathogenic mutations in BRCA1 increase risk for ovarian cancer as well as for a range of other tumours. After genetic testing, the gene mutation status can be used for cancer risk prediction in affected and healthy individuals. But even when no pathogenic variant in an established breast cancer gene is detected, persons can still be at increased risk of breast cancer due to a mutation in a gene that was not tested, or more likely, a probably polygenic, heritable component that is not (yet) known. With all the technical advances that have been made in sequencing in recent years, gene panel testing has been developed, enabling testing for mutations, simultaneously, in a set of multiple genes. Currently, genetic testing and breast cancer risk prediction is mainly done for high-risk individuals and families in the clinical genetic setting. However, the infrastructures for implementation of population-based genetic testing are under development.

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Actas de conferencias sobre el tema "Incremental lifetime cancer risk"

Cao, Yin, Kana Wu, Raaj Mehta, David Drew, Mingyang Song, Paul Lochhead, Jacques Izard et al. "Abstract A24: Lifetime use of antibiotics and risk of colorectal adenoma". En Abstracts: AACR Special Conference: Colorectal Cancer: From Initiation to Outcomes; September 17-20, 2016; Tampa, FL. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.crc16-a24.

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Ho, Vikki, Marie-Élise Parent, Javier Pintos, Michal Abrahamowicz, Lise Gauvin, Jack Siemiatycki y Anita Koushik. "Abstract A47: Lifetime occupational physical activity and lung cancer risk in men and women". En Abstracts: Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; Oct 27-30, 2013; National Harbor, MD. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1940-6215.prev-13-a47.

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Alkufi, Abdulhussein A., Shaymaa Awad Kadhim y Shatha F. Alhous. "Comparison of excess lifetime cancer risk for different age groups for selected flour samples". En TECHNOLOGIES AND MATERIALS FOR RENEWABLE ENERGY, ENVIRONMENT AND SUSTAINABILITY: TMREES21Gr. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0093069.

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Wang, Jun, Xuehong Zhang, Andrew H. Beck, Laura C. Collins, Wendy Chen, Rulla M. Tamimi, Aditi Hazra, Bernard Rosner y Susan E. Hankinson. "Abstract 1270: Lifetime alcohol consumption and risk of breast cancer, by tumor androgen receptor expression". En Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1270.

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Kurta, Michelle y Brenda Diergaarde. "Abstract A95: The impact of fertility drug use, infertility, and lifetime ovulation on ovarian cancer risk". En Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1940-6207.prev-11-a95.

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Dieli-Conwright, Christina, Jane Sullivan-Halley, Alpa Patel, Michael Press, Kathi Malone, Giske Ursin, Ronald Burkman, Brian Strom, Michael Simon y Leslie Bernstein. "Abstract 5739: Lifetime recreational physical activity, hormone therapy use and breast cancer risk in postmenopausal women". En Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5739.

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Zhang, Jianjun y Margaret Hoyt. "Abstract 5746: Lifetime body mass index trajectory and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial". En Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5746.

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Stolzenberg-Solomon, Rachael Z., Catherine Schairer, Albert Hollenbeck y Debra T. Silverman. "Abstract B5: Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study". En Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1940-6207.prev-11-b5.

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Kunzmann, Andrew, Helen Coleman, Wen-Yi Huang y Sonja Berndt. "OWE-023 The association of lifetime alcohol use with mortality and cancer risk: a prospective cohort study". En British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.319.

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Hidajat, Mira, Damien McElvenny, Laura MacCalman, Carla Alexander, John Cherrie, Andrew Darnton, Raymond Agius y Frank de Vocht. "P029 Lifetime cancer risk in the british rubber industry. a retrospective cohort with 45 year follow-up". En Occupational Health: Think Globally, Act Locally, EPICOH 2016, September 4–7, 2016, Barcelona, Spain. BMJ Publishing Group Ltd, 2016. http://dx.doi.org/10.1136/oemed-2016-103951.354.

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Informes sobre el tema "Incremental lifetime cancer risk"

Freudenheim, J. L. Lifetime Alcohol Exposure and Breast Cancer Risk. Fort Belvoir, VA: Defense Technical Information Center, octubre de 1998. http://dx.doi.org/10.21236/ada359844.

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Freudenheim, Jo L. Lifetime Alcohol Exposure and Breast Cancer Risk. Fort Belvoir, VA: Defense Technical Information Center, octubre de 2000. http://dx.doi.org/10.21236/ada392673.

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