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Literatura académica sobre el tema "Improved recovery"

Autor: Grafiati

Publicado: 25 de mayo de 2024

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Artículos de revistas sobre el tema "Improved recovery"

Mitka, M. "Stroke Recovery Improved". JAMA: The Journal of the American Medical Association 287, n.º 4 (23 de enero de 2002): 443—a—443. http://dx.doi.org/10.1001/jama.287.4.443-a.

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Mitka, Mike. "Stroke Recovery Improved". JAMA 287, n.º 4 (23 de enero de 2002): 443. http://dx.doi.org/10.1001/jama.287.4.443-jqu10013-2-1.

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Durzan, Don J. "Improved Somatic Embryo Recovery". Nature Biotechnology 5, n.º 6 (junio de 1987): 636–38. http://dx.doi.org/10.1038/nbt0687-636c.

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Winecki, Slawomir, Haskell J. Fought, Meghan Harley Yugulis, Darwin Argumedo, William W. Gibbs, Robert A. Stonebraker, Brian J. Sikorski, Martin V. Melnik y Richard J. Davis. "Improved oil recovery sensor". Sensors and Actuators A: Physical 295 (agosto de 2019): 308–16. http://dx.doi.org/10.1016/j.sna.2019.06.018.

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Yuan, DongBing, Bintai Xu y Sheng Gao. "A Recovery Algorithm of Power Quality Big Data Based on Improved Differential Kriging". Journal of Nanoelectronics and Optoelectronics 16, n.º 9 (1 de septiembre de 2021): 1444–49. http://dx.doi.org/10.1166/jno.2021.3099.

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The integrity of power quality big data directly affects the state sensing accuracy and operation safety of the power system. Therefore, the recovery algorithm of power quality big data based on improved differential Kolding is studied to improve the big data recovery effect. The trend turning point is used to divide the time series of power quality big data, and the characteristic matrix of time series is constructed. The recovery model of power quality big data is built according to the characteristic matrix. By improving the differential Kriging solution model, the estimated value of the data to be recovered is obtained and the big data recovery is completed. Experimental results show that the convergence speed is the fastest when the initial scaling factor is 0.3. The algorithm can effectively recover the big data of random missing and continuous missing. In different fault recovery scenarios, the signal-to-noise ratio (SNR) is high, the structure similarity value is high, the data recovery accuracy is accurate, and the integrity of the restored data is better.

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Pemmadi, Venkata Rao, JInal Patel y Ashish Nagar. "Enhanced Oil Recovery". International Journal for Research in Applied Science and Engineering Technology 11, n.º 2 (28 de febrero de 2023): 834–41. http://dx.doi.org/10.22214/ijraset.2023.48875.

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Abstract: Enhanced oil recovery procedures, which are part of improved oil recovery, are used to recover the leftover oil include Steam injection, Polymer flooding, Gas injection and Water injection. Only a small percentage of the total hydrocarbons in the reservoir can be recovered using standard oil recovery technologies. Even if normal recovery procedures are implemented, almost 2 trillion barrels of conventional oil and 5 trillion barrels of heavy oil will remain in reservoirs around the world. Many factors, both economic and technological, influence the strategy chosen and the projected recovery. The study evaluates the EOR approaches that are currently in use in the field. The current EOR technologies are put into context, with the technical reasons for their failure highlighted. Recovering additional oil is difficult and expensive, and it has only been done successfully in a few cases under strict conditions. Despite this, EOR will continue to play a significant role in oil production due to rising energy demand and constrained supply. It is estimated that a significant amount of research is required to develop new technologies for recovering almost two-thirds of the oil that remains unrecoverable in the reservoir. New methods of enhanced oil recovery improves the efficiency of existing processes and reduce demand for new reserves in the longer term. This paper represents the new technologies evolved in the petroleum industry for Enhanced oil recovery.

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Guhl, Andrea C., Valentin-G. Greb, Bernhard Schulz y Martin Bertau. "An Improved Evaluation Strategy for Ash Analysis Using Scanning Electron Microscope Automated Mineralogy". Minerals 10, n.º 5 (25 de mayo de 2020): 484. http://dx.doi.org/10.3390/min10050484.

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Sewage slush ashes are materials composed of polyphase particles. Ashes are fine-grained with many amorphous components, and analytical techniques such as X-ray diffractometry cannot recover all the properties. For sewage sludge ash, treatment often focuses on phosphate recovery. Automated mineralogy techniques were applied in order to study phosphate associations and their behavior towards chemical processes. This work shows the distribution of phosphate content in sewage sludge ash and identifies the main recovered phosphate phases in acid leaching. Data interpretation was focused on the target material, phosphate. The approach documents spectra labelling with respect to one target component, phosphorus. This is a tool for assessing sewage sludge ashes towards their phosphate recovery potential and highlights issues processing needs to address.

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Liu, S. M., S. R. Sykes y P. R. Clingeleffer. "Improved in ovulo embryo culture for stenospermocarpic grapes (Vitis vinifera L.)". Australian Journal of Agricultural Research 54, n.º 9 (2003): 869. http://dx.doi.org/10.1071/ar03053.

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In ovulo embryo rescue techniques have been used to recover new hybrids from seedless × seedless grape crosses. This study was conducted to increase efficiency by investigating effects of genotype, medium, and ovule removal age on ovule elongation, embryo recovery, growth, and plantlet formation. Ovules from self-pollinated berries of seedless varieties Sunmuscat, Merbein Seedless, and Marroo Seedless were cultured at 30, 43, 60, and 70 days after flowering (DAF) in a range of media, some of which were supplemented with gibberellic acid (GA3) and indole-3-acetic acid (IAA). The effect of activated charcoal (AC) in media on rescued embryos was also investigated. Ovules exhibited continuous growth in vivo and in vitro. The most vigorous growth was observed for ovules cultured at 30 and 43 DAF, but more embryos were recovered from ovules cultured at 60 and 70 DAF. Ovule growth and embryo production in vitro were improved in Bouquet and Davis (BD) and Nitsch and Nitsch (NN) media. Supplementation with GA3 increased embryo recovery rates. Highest embryo recovery rates were 18.1%, 9.6%, and 12.2% for Sunmuscat, Merbein Seedless, and Marroo Seedless, respectively, when ovules were excised and cultured at 60 or 70 DAF in either BD or NN media. In vitro embryo survival and plantlet formation were higher for torpedo-shaped embryos, and improved greatly in 6-benzyladenine (BA)-supplemented woody plant (WP) medium containing 0.3% AC. Embryo recovery was improved by excising and culturing ovules at 60 DAF in BD or NN media and then by transferring embryos to WP medium supplemented with BA and AC.

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Feng, Jia Mei, Yuan Cheng Yao y Ming Wei Qin. "An Improved Timing Recovery Algorithm Design". Applied Mechanics and Materials 130-134 (octubre de 2011): 2997–3000. http://dx.doi.org/10.4028/www.scientific.net/amm.130-134.2997.

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Timing-jitter is an important index of timing recovery algorithm. This paper describes impact-factors of timing-jitter in an AWGN channel and discovers that input noise have great influence on it, proposed an improved timing recovery method for adding a loop gain to reduce it. Simulations demonstrate that a timing recovery with loop gain can have performance superior to that of without it, and got the conclusion that add loop gain at the range of 0.1 to 0.3 both timing jitter and timing recovery points can reach minimum values. Better yet, when choose a loop gain at 0.1, timing jitter decrease from ±0.2 to ±0.08, and system’s error rates also have obverse decrease.

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Niemann, Henrik, Jakob Stoustrup y Bahram Shafai. "Improved recovery in H ∞ /LTR design". IFAC Proceedings Volumes 29, n.º 1 (junio de 1996): 1363–68. http://dx.doi.org/10.1016/s1474-6670(17)57856-8.

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Tesis sobre el tema "Improved recovery"

Sánchez, Monsalve Diego Alejandro. "Downhole Gasification (DHG) for improved oil recovery". Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642042.

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Gas injection, the fastest growing tertiary oil recovery technique, holds the promise of significant recoveries from those depleted oil reservoirs around the world which fall into a pressure range of (50-200) bar mainly. However, its application with the usual techniques is restricted by the need for various surface facilities such as enormous gas supply and storage. The only surface facility that downhole gasification of hydrocarbons (DHG) requires, on the other hand, is a portable electricity generator. DHG consists in producing inert gases, H2, CO, CO2 and CH4 through the steam reforming reaction of a part of the produced oil in a gasifier-reformer reactor positioned alongside the producer well in the reservoir. The gases, mainly H2 -the most effective displacing gas among produced gases- are injected into a gas cap above the oil formation, to increase oil recovery through a gas displacement drive mechanism. So far, DHG has only been tested under laboratory conditions using methane, pentane/reservoir gas and naphtha/reservoir gas as feedstock at conditions of reservoir pressure up to 130 bar. The studies varied reaction temperature, steam to carbon (S/C) ratio, catalyst types and catalyst loading in the gasifier-reformer reactor of a small pilot scale rig. These experimental studies demonstrated that pressure is one of the main factors influencing the effectiveness of the DHG process. From this starting point, the present investigation was directed at extending the pressure range up to 160 bar in the gasifier-reformer reactor using a naphtha fraction as feedstock in order to investigate whether the conversion and H2 concentration in produced dry gas can be maintained at acceptable levels under conditions of high pressure. To this end, experimental studies were carried out within the laboratory using the existing DHG rig on the small pilot scale, which was successfully commissioned and revamped for the purposes of this study. Initially, the investigation focused on exploring operating conditions, namely, steam to carbon (S/C) ratio, length of the gasifier-reformer reactor tube/ catalyst loading and the relative performance of two different catalysts. Subsequently, experiments on shutdown/start up cycles followed by variation of temperature were performed to simulate the effect of sudden electrical disruptions that usually occur in field operations. Experimental results using naphtha at pressure from 80 to 160 bar at 650 ºC, S/C= 6 achieved total feedstock conversion, no coke deposits and, most importantly, high H2 concentration in the produced dry gas (56-63 vol. % plus other gases). The best result was obtained with a crushed HiFUEL R110 catalyst (40-60 wt. % of NiO/CaO.Al2O3) and a reactor tube length of 72 cm, but the results with a C11-PR catalyst (40 wt. % of NiO/MgO.Al2O3) and a reactor tube length of 30 cm were similarly favourable. These results were supported by results of a numerical DHG model which indicated total feedstock conversion and values of H2 around 67 vol. % (using n-heptane as model surrogate). The results suggest that the DHG process is technically feasible at the pressure values studied, perhaps up to 200 bar where there are many hundreds of depleted, light oil reservoirs, especially in North America and other parts of the world below that pressure value.

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Essiagne, Franck-Hilaire. "Underground transformation and upgrading for improved oil recovery". Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/42888.

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Petroleum refining has entered a significant transition period as the industry moves into the 21st century and the demands for petroleum and petroleum products continue to show a sharp growth in recent years. Refinery operations have evolved to include a range of next-generation processes as the demand for transportation fuels and fuel oil has shown steady growth. The research described in this thesis has been focused on an investigation of hydrothermal processing of hydrocarbons, mainly heavy oils. Experiments were carried out at temperatures from 300 to 380 °C and at a pressure of 220 ± 10 bar in both batch and flow systems separately by using 1/4-inch stainless steel tubing. The experiments were performed by using different reaction systems: toluene/H2O, toluene/H2O2, toluene/H2O/air, and toluene/H2O2/air. A comparative study of these reaction systems spiked with sulphur and metals (nickel, vanadium) were also conducted at the same conditions. Toluene conversion was investigated in a batch reactor at supercritical conditions in the presence of water. The conversion of toluene increases with temperature and steam/carbon (S/C) molar ratio (i.e. H2O to toluene ratio), conditions that provide favourable operating conditions for toluene conversion order to get high content products (gases and liquids). The toluene conversion yields multiple desirable lighter (liquid) hydrocarbons. The major liquid products include benzaldehyde, ethylbenzene, cresols (opm-cresols), styrene, benzyl alcohol and benzoic acid. Progressively larger quantities of these products are possible at higher temperatures and at higher H2O/toluene ratios. The efficiency of toluene conversion into products reaches almost 91% at 380 °C at a H2O/toluene ratio of 3 to 1. The yields improve monotonically as longer reaction times are allowed. Furthermore, when adding H2O2, the yield of the major liquid products benzaldehyde, ethylbenzene, cresols (opm-cresols), styrene, benzyl alcohol, benzoic acid increases with temperature and at higher H2O2/toluene ratios. The efficiency of toluene conversion into products reaches almost 40% at 380 °C at H2O2/toluene ratio equals to 3:1 with 5% H2O2 in 5 min of residence time. The yields improve at longer residence times. In the gas phase, H2 increases with an increasing H2O2 concentration while again, the yield of CH4 is small. The CO content increases up to 40% when between 6% and 8% H2O2 is used at temperatures around 380 °C whereas the CO2 content decreases. The conversion efficiency of toluene converted into liquid and gas products increases with temperature. This increase is accentuated with an increase in the H2O2/toluene ratio. Toluene conversion is slightly higher in the water/toluene mixture (90%) than the H2O2/toluene mixture (just below 90%). This is important, since along with the increased cost associated with the need for H2O2 and hence the increased overall cost of operation, it suggests that the water/toluene system is the more desirable one to consider further. Experimental results also revealed that a maximum of about 90% of the Ni-TPP was converted to intermediate and final Ni-based products at a temperature of 380 °C and after a reaction time of 90 min. Under the same conditions, around 67% of the Ni was removed by the action of supercritical water, proving that supercritical water is capable of removing Ni from Ni-TPP. The same batch reactor system was also used to study vanadium removal. V-TTP (a vanadium-containing compound which was added to the toluene) also reacted with SCW suggestions a pathway for vanadium removal. The effects of reaction time and temperature were investigated, showing that approximately 91% of V-TPP was converted to intermediate and final products at a temperature of 380 °C and reaction time of 100 min. Under the same conditions, approximately 82% of the vanadium was removed. This process was deemed successful since it did not use a catalyst. Finally, the removal of unwanted/undesirable sulphur from the oil was also considered. A gradual increase in the % DBT conversion was found at higher temperatures. The maximum DBT conversion was achieved at the highest investigated temperature, i.e. 380 °C. A maximum DBT conversion of ~ 97% was recorded after 30 min of reaction time. Importantly, and contrary to the findings concerning the conversion of toluene, the introduction of H2O2 lead to a considerable improvement in the metal removal potential.

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Ramidi, Harika Reddy. "An Improved Crash Recovery Approach for Distributed Systems". OpenSIUC, 2010. https://opensiuc.lib.siu.edu/theses/218.

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In this paper, we have addressed the complex problem of recovery for concurrent failures in distributed computing environment. We have proposed a new approach in which we have dealt with effectively both orphan and lost messages. The proposed check pointing and recovery approaches enable a process to restart from its recent checkpoint and hence guarantees the least amount of re-computation after recovery. It also means that a process needs to save only its recent local checkpoint. The proposed value of the common check pointing interval enables an initiator process to log the minimum number of messages sent by each application process. The message complexity of the proposed check pointing algorithm as well as the recovery approach is O(n).

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Henson, Richard M. "Geologically based screening criteria for improved oil recovery projects". Thesis, Heriot-Watt University, 2003. http://hdl.handle.net/10399/307.

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Kim, Jeong-Hee. "Improved recovery of gravity anomalies from dense altimeter data /". The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487862399447755.

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Chewaroungroaj, Jirawat. "Improved procedures for estimating uncertainty in hydrocarbon recovery predictions /". Digital version:, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992767.

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Lindgård, Ann. "Improved bioenergetic recovery during experimental ischemia and reperfusion by irradiation /". Göteborg : Göteborg University, Bioenergetics Group, Department of Surgery, Wallenberg Laboratory & Lundberg Laboratory for Bioanalysis, Sahlgrenska Academy, Göteborg University, 2007. http://hdl.handle.net/2077/7505.

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Du, Plessis Jan Antonie. "Improved gold recovery by accelerated gravity separation / du Plessis J.A". Thesis, North-West University, 2011. http://hdl.handle.net/10394/7364.

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This project was specifically aimed at using increased acceleration separation, as a method to optimize the recovery of gold in an ore body mainly consisting of hematite. The specific gravity of gold is much higher in comparison to the carrying material, making it possible to separate gold from other materials such as silica, base metals and their oxides, usually associated with gravitation–gold–recovery processes. The ore body investigated in this project originated from a mined gold reef containing a large proportion of gold locked inside the gold pyrite complexes. In the mine's processing plant a gold pyrite concentrate was produced by means of a flotation process. The roasting process that followed, oxidized the pyrite to iron oxide (hematite) and sulphur dioxide. The gold particles which were locked up inside the pyrite gold complex were exposed or liberated, allowing the chemicals to penetrate the complex and dissolve the gold. After the cyanide gold extraction process, the material was pumped on to a mine reserve dump, referred to as tailings or tailings reserve dump. The tailings usually contain iron oxides, free gold, gold associated with iron oxides and gold associated with silica, and free silica, commonly referred to as calcine. The gold content on the calcine dump was significantly lower than the flotation concentrate before the extraction of the gold and it was no longer viable for the mine to process the tailings further. As the volume of the mine reserve dump increased over the years, it became viable to recover the gold in a high volume low grade plant. Several attempts were made to recover the gold in this dump, but due to the high cost of processing and milling the material, it was not done. The norm in the mining industry is that it is impossible to concentrate the gold by means of gravity separation techniques where the average particle sizes are smaller than 50 um in diameter and upgrading with inexpensive gravity separation techniques was ruled out by the mine, because the average particle sizes were too small. The dump investigated in this project differed from other reserve dumps in that the main phase of material in this dump was hematite and not silica. A suspension of this material would have different fall–out properties than other mine reserve dumps, because of the hematite's high specific gravity compared to silica. This property of the material birthed the idea that the material will respond positively to high acceleration separation, although the particle sizes were too small for effective upgrading according to the norm in the mining industry. Using acceleration concentration as a first stage in the gold recovery process the production cost per gram of gold produced could be reduced significantly. Firstly, the volume of concentrated material to be treated in the chemical extraction process was reduced ninety percent and secondly, the gold concentration was increased significantly. If the gold could be concentrated to more than twenty grams of gold per ton, it could be extracted economically with an aggressive chemical processes. This was not possible with low grade material contained in the dump. The theoretical principle, on which this project was based, was to make use of high acceleration separation to establish separation between the particles associated with the gold, and the particles not associated with gold. Applying a high gravitational force would have an influence on the velocity by which the particles would fall–out in a suspension. As the acceleration force increased the fall–out velocity would also be increased and the particles with higher specific gravity would be affected more. A factor that was equally important was the particle size and weight distribution. A large hematite particle would compete with a small gold particle due to the similarity in weight. This could cause loss in small gold particles or retention of hematite particles with no gold content. Very little scientific information was available on the material investigated and in order to assemble a concentration plant setup, the head grade and particle size distribution for both the dump and bulk sample were determined accurately. Thereafter, chemical analyses and mineralogical examination were done on a representative sample of the bulk sample, determining the chemical composition of the material. The results obtained thereof were evaluated and used to configure a pilot plant. A large bulk sample was processed in the pilot plant and from the analytical results the efficiency could be evaluated. The results at optimum acceleration forces applied, resulted in a recovery of 5% of the mass, with a gold concentrate of 90 g/t Au, which represented 58% recovery of the gold. The hematite with high specific gravity as main phase positively influenced the high acceleration separation process. It proved that if the specific gravity of particles in a suspension were increased, high acceleration separation could be applied effectively to separate much smaller particle sizes.
Thesis (M.Sc. Engineering Sciences (Chemical and Minerals Engineering))--North-West University, Potchefstroom Campus, 2012.

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Taura, Usman Habu. "Improved numerical simulation of non-thermal enhanced heavy oil recovery". Thesis, Heriot-Watt University, 2017. http://hdl.handle.net/10399/3380.

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The dependence on unconventional resources such as heavy oil is on the rise due to geometric increase in demand for energy and the decline of production from mature conventional oil reservoirs. Heavy oil reservoirs contain oil that has some limited mobility under reservoir conditions and only a small fraction of the oil-in-place can be recovered by primary technique which involve harnessing the internal reservoir energy. The remaining oil after the primary depletion is still mostly continuous and present a valuable target for enhanced recovery. However, most of these reservoirs are relatively thin, making them poor candidates for thermal methods, in addition to associated high energy requirement and adverse environmental effects of the heating process. Therefore, any incremental oil recovery must be through non-thermal methods, such as waterflooding, chemical and gas injection. These methods however suffer from adverse mobility ratio which significantly affect the efficiency of the displacement process. The simulation of these processes for the purpose of reservoir prediction and performance is a herculean task due to the complex physics of instability and compositional effect taking place that is not fully understood. In this thesis, the results of improved numerical simulation techniques of non-thermal heavy oil recovery were presented, demonstrating the viability of the techniques as simulation methods heavy oil non-thermal enhanced heavy oil recovery (EHOR). Several displacement mechanisms were identified through the simulation of the secondary and tertiary processes that contributed to significant incremental heavy oil recovery. A systematic lumping scheme of the heavy oil components into pseudo-components based on the behaviour of the produced oil was proposed. A new methodology for the estimation of relative permeability from displacement with instability and compositional effect using a two-dimensional (2D), high-resolution model to effectively capture the finger, and a versatile, three-parameter function (L.E.T correlation) was demonstrated. A semianalytical approach through a combination of theoretical and an empirical prediction method based on the famous works of Koval, and Todd and Longstaff on viscous fingering was employed for the verification of the estimated relative permeability. Lastly, a multiscale approach to history matching, for the estimation of unstable relative permeability that is computationally more efficient, was proposed. It involves the history matching of a set of coarse grid models to predict the fine-scale relative permeability. In this approach, fine-scale information was resolved without direct solution of the global fine-scale problem. The results showed that the time required to estimate relative permeability using the multiscale approach was only about 35% required to estimate the same relative permeability using a single high-resolution model. The memory requirement for the approach was also about 50% required for simulation of the single high-resolution model. Therefore, the lower memory size and computations required in the multiscale approach mean that a less powerful computer can be used to estimate the relative permeability curves for unstable displacements with accuracy similar to that obtained using a high-resolution model approach.

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Liu, Frances D. (Frances Deen). "Mechanical modulation of indirect repair mechanisms for improved hematopoietic recovery". Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119976.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 243-264).
Hematopoietic stem cell or bone marrow transplantation is a curative treatment for multiple hematologic malignancies. However, the myeloablative conditioning regimens preceding cell delivery have rendered the rapid and sustained hematopoietic recovery after transplantation an outstanding challenge. Successful long-term engraftment of hematopoietic stem cells is dependent largely on the surrounding stroma components or hematopoietic niche. Cell types within this niche that support hematopoietic recovery include two adherent cell types, mesenchymal stromal cells (MSCs) and vascular endothelial cells (VECs). The niche also contains many biophysical and mechanical cues including cell contractility against other cells or the matrix, pulsatile fluid flow, differences in localized niche stiffness, and occupation of fluid volume by macromolecules. This thesis aims to understand how VECs and MSCs respond to these cues ex vivo, and how these cues can be used to engineer VEC and MSC phenotypes that can predictably support hematopoietic recovery in vivo. VEC-mediated angiogenesis and angiocrine signaling are known to support hematopoietic recovery in vivo. In this thesis, we first explored how the biophysical cue of macromolecular crowding (MMC) and the mechanical cue of strain can regulate angiogenesis. The addition of synthetic MMC to in vitro cultures replicates the endogenous occupation of fluid space due to macromolecules. We explored how MMC affects the basement membrane formation of VECs, and determined that MMC can increase the deposition, areal spread, and alignment of basement membrane proteins. Even with the addition of biochemical signals from pericytes, this biophysical cue of MMC played a dominant role in the organization of the basement membrane. Pericytes that surround blood vessels and the basement membrane have been shown to exert contractile forces, which results in a hoop strain in the blood vessel wall. We translated this strain to in vitro VEC cultures by applying static, uniaxial strain to confluent VEC monolayers using a polydimethyl siloxane (PDMS) substrata, which allowed us to decouple the mechanical cue of pericytes from their chemical signaling. The application of 10% engineering strain was sufficient to induce cell-cycle re-entry in a quiescent monolayer. We then went on to demonstrate in a quasi-3D assay that straining the VECs also produced angiogeniclike sprouts. Together, these results show that biophysical and mechanical cues of the hematopoietic niche alone are sufficient to direct VEC-derived extracellular matrix formation and to induce angiogenic sprouting. Thus, future models of in vitro angiogenesis must include these cues to more comprehensively and accurately replicate the in vivo hematopoietic niche. Paracrine signaling from MSCs is crucial in regulating the self-renewal capacity and differentiation of hematopoietic stem and progenitor cells (HSPCs) that re-populate the bone marrow compartment in vivo. Thus, we then explored if and how to modulate MSC paracrine signaling or the MSC secretome. Like VECs, MSCs are known to respond to microenvironment cues such as substratum stiffness. We developed tissue-culture compatible PDMS-based substrata with tunable viscoelastic properties to assay potential mechanosensitivity. We characterized the bulk and surface properties of this substrata to verify that we could tune stiffness across three orders of magnitude without altering material surface biochemistry. When we expanded the MSCs on compliant substrata (elastic modulus ~I kPa), we found that we could increase the expression of osteopontin as well the expression of at least a dozen other secreted proteins without altering cell capacity for terminal differentiation. We observed changes in the MSC secretome that were significantly correlated to the viscoelastic properties (shear storage and loss moduli G' and G", respectively, and the ratio of G"/G' as tan [delta]) of the substratum material. These results suggested that we could mechanically modulate the MSC secretome using the viscoelastic properties of the extracellular substrata. Finally, we went on to explore how these mechanically modulated changes in MSC phenotype could regulate hematopoiesis in vitro and support hematopoietic recovery in vivo. To do so, we used statistical regression modeling (partial least squares regression or PLSR) to identify the components of the MSC secretome that were significantly correlated with improved radiation rescue and hematopoietic recovery in mouse models of hematopoietic failure. We then characterized the expression of these key secretome components in our mechanoprimed MSCs. The mechanoprimed MSCs expressed equal or higher concentrations of these proteins as a diameter-defined subpopulation of MSCs we previously identified to be therapeutically effective. Using the regression parameters from PLSR and the new expression data from our mechanoprimed MSCs, we then predicted how our mechanoprimed MSCs would elicit radiation recovery of the bone marrow compartment in vivo. From these computational predictions, we found that our mechanoprimed MSCs could potentially improve survival proportion in this in vivo model of hematopoietic failure. Thus, we tested mechanoprimed MSCs by expanding them in co-culture with HSPCs to determine if the MSCs could regulate hematopoiesis in vitro. We found that mechanoprimed MSCs could maximize the proliferation or expansion of HSPCs when co-cultured on top of our most compliant PDMS substrata (~I kPa). When grown on stiffer PDMS substrata (100 kPa), those MSCs could prime differentiation of the HSPCs down myeloid lineages, which include red blood cells. Together, these results demonstrate that these mechanoprimed MSCs can be used to modulate the ex vivo expansion and differentiation of HSPCs. Lastly, we tested these mechanoprimed MSCs in our sub-lethally irradiated mouse models of hematopoietic failure. Our mechanoprimed MSCs significantly increased the survival of the mice. Interestingly, this increased survival and improved hematopoietic recovery outperformed the survival predicted from our regression model. We also observed recovery of red blood cells, white blood cells, and platelets in mice treated with mechanoprimed MSCs, suggesting complete recovery of all hematopoietic lineages. In summary, we have explored how biophysical and mechanical cues can modulate VEC and MSC phenotype in vitro. In the case of VECs, the results presented in this thesis further the development of more accurate in vitro models of angiogenesis. Accurate in vitro models of angiogenesis are necessary to elucidate the mechanisms by which VECs regulate hematopoietic recovery in vivo. We also characterized the components of the MSC secretome correlated with improving hematopoietic recovery and demonstrated that we could engineer the expression of these same MSC secretome components using substratum viscoelastic properties. Lastly, we validated that these mechanically modulated MSCs led to improved survival outcome in vivo. The work presented in this thesis furthers our understanding of how biophysical and mechanical cues regulate hematopoietic niche components that participate in indirect repair of the bone marrow. We also demonstrated how these same cues can be applied in vitro to improve cell-based therapies for hematopoietic recovery in vivo.
by Frances D. Liu.
Ph. D.

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Libros sobre el tema "Improved recovery"

Sorbie, K. S. Polymer-Improved Oil Recovery. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8.

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Polymer-improved oil recovery. Glasgow: Blackie, 1991.

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Negash, Berihun Mamo, Sonny Irawan, Taufan Marhaendrajana, Hasian P. Septoratno Siregar, Sudjati Rachmat, Luky Hendraningrat y Andi Setyo Wibowo, eds. Selected Topics on Improved Oil Recovery. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8450-8.

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McFeters, Gordon A. Injury and the improved recovery of coliform bacteria in drinking water. Cincinnati, OH: U.S. Environmental Protection Agency, Water Engineering Research Laboratory, 1985.

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Grube, John P. Reservoir characterization and its application to improved oil recovery from the Cypress Formation (Mississippian) at Richview Field, Washington County, Illinois. Champaign, Ill: Illinois State Geological Survey, 1999.

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Udegbunam, Emmanuel O. Integrated geologic and engineering model for improved reservoir development and management at Energy Field, Williamson County, Illinois. Champaign (Natural Resources Building, 615 E. Peabody Dr., Champaign 61820-6964): Illinois State Geological Survey, 1994.

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Leetaru, Hannes E. Improved oil recovery from the Aux Vases (Mississippian) Formation at Boyd Field, Jefferson County, Illinois. Champaign, Ill: Illinois State Geological Survey, 1993.

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Leetaru, Hannes E. Seismic stratigraphy, a technique for improved oil recovery planning at King Field, Jefferson County, Illinois. Champaign, Ill: Illinois State Geological Survey, 1996.

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Chadwick, J. W. Recovery of benthic invertebrate communities in Silver Bow Creek, Montana, following improved metal mine wastewater treatment. S.l: s.n, 1986.

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Survey, Illinois State Geological. Improved and enhanced oil recovery in Illinois by reservoir characterization: Standard operating and QA/QC procedures. [Champaign, Ill.]: Oil and Gas Section, Illinois State Geological Survey, 1993.

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Más fuentes

Capítulos de libros sobre el tema "Improved recovery"

Archer, J. S. y C. G. Wall. "Improved Hydrocarbon Recovery". En Petroleum Engineering, 191–217. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-010-9601-0_12.

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Sorbie, K. S. "Introduction to polymer flooding". En Polymer-Improved Oil Recovery, 1–5. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_1.

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Sorbie, K. S. "Structure of the main polymers used in improved oil recovery (IOR)". En Polymer-Improved Oil Recovery, 6–36. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_2.

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Sorbie, K. S. "Properties of polymer solutions". En Polymer-Improved Oil Recovery, 37–82. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_3.

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Sorbie, K. S. "Polymer stability". En Polymer-Improved Oil Recovery, 83–125. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_4.

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Sorbie, K. S. "Polymer retention in porous media". En Polymer-Improved Oil Recovery, 126–64. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_5.

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Sorbie, K. S. "Polymer rheology in porous media". En Polymer-Improved Oil Recovery, 165–207. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_6.

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Sorbie, K. S. "Polymer transport in porous media". En Polymer-Improved Oil Recovery, 208–45. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_7.

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Sorbie, K. S. "Oil displacement using polymers". En Polymer-Improved Oil Recovery, 246–311. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_8.

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Sorbie, K. S. "Application and planning of field polymer floods". En Polymer-Improved Oil Recovery, 312–40. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3044-8_9.

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Actas de conferencias sobre el tema "Improved recovery"

Ayirala, Subhash C., Abdulkareem M. AlSofi, Zuhair A. AlYousef, Jinxun Wang, Moataz O. Abu Alsaud y Ali A. AlYousef. "SmartWater Based Synergistic Technologies: A Next Recovery Frontier for Enhanced Oil Recovery". En SPE Improved Oil Recovery Conference. SPE, 2022. http://dx.doi.org/10.2118/209360-ms.

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Abstract In this work, the synergistic effects of SmartWater in polymer flooding, surfactant-polymer flooding, carbonated waterflooding, and foam assisted gas injection processes were explored. A suite of multiscale experimental data was analyzed to demonstrate and quantify the benefits of water chemistry synergies in these different enhanced oil recovery (EOR) methods. The multiscale experimental data analyzed comprised of polymer rheology, core floods, foam stability and rheology, besides evaluating the zeta potential results obtained from surface complexation modeling (SCM). SmartWater increased the oil recoveries by 5-7% in addition to reducing the polymer concentration requirements by one-third in polymer flooding. Synergizing SmartWater with surfactant-polymer flooding increased the oil recovery by 4% besides lowering the polymer and surfactant consumption by 50%. SmartWater has been found to synergistically combine with carbonated waterflooding to increase the CO2 dissolved volumes by 25-30% for effectively lowering the pH at both calcite/brine and crude oil/brine interfaces. The availability of more CO2 dissolved volumes in SmartWater can cause enhanced oil swelling, greater oil viscosity reduction, and increased wettability alteration through pH induced modification of surface charges for higher oil recovery. SmartWater increased the foam stabilities by 2-3 times, foam apparent viscosities by 1.5 times, and porous media foam pressure drops by 50% to ensure the propagation of more stable and viscous foams deeper into the reservoir for better mobility control. The findings of this study have a practical impact on how the industry can efficiently operate EOR projects. SmartWater-based synergistic technologies can reduce the costs due to lowered volume requirements of different EOR agents and they can also increase oil recoveries to result in more practical, efficient, and economical EOR projects in the field.

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Aminzadeh, Behdad, Sriram Chandrasekhar, Mayank Srivastava, Tom Tang, Art Inouye, Mauricio Villegas, Monika Valjak y Varadarajan Dwarakanath. "Impact of Brine Chemistry on Waterflood Oil Recovery: Experimental Evaluation and Recovery Mechanisms". En SPE Improved Oil Recovery Conference. SPE, 2022. http://dx.doi.org/10.2118/209426-ms.

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Abstract Water floods are typically conducted using the least expensive, easily available, non-damaging brine. Very little attention is given to the possibility of changing brine composition to improve oil recovery. Over the last 20 years, there has been laboratory and field trial evidence that shows changing brine chemistry, especially to low salinity, can sometimes increase the recovery. The various mechanisms of additional oil recovery from changing brine chemistry are not entirely clear. We report here on the effect of using low salinity and divalent altered brines on oil recovery through a variety of laboratory methods and materials. More than twenty corefloods were conducted to evaluate the effect of brine chemistry and initial wettability on incremental oil recovery. We also performed phase behavior tests, contact angle measurements, and wettability index measurements to evaluate recovery mechanisms. Initial wettability of the core was altered by ageing it with different crude oil containing wide range of asphaltene content. The core flood with lowest wettability index (least water-wet) produced about 12% incremental recovery while the most water-wet core only produced ∼ 4% during the secondary low salinity waterflood.

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Wang, Dongmei, Randall Scott Seright y Jin Zhang. "Wettability Survey in Bakken Shale Using Surfactant Formulation Imbibition". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/153853-ms.

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Leung, Juliana Yuk Wing. "Scale-up of Effective Mass Transfer in Vapor Extraction Process for Heterogeneous Reservoirs". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/153862-ms.

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Al Otaibi, Fawaz Mohammed, Mohammed H. Khaldi, James Joseph Funk y Shouwen Shen. "New Insights Into Clay Swelling: Supercritical CO2 Interaction With Montmorillonite". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/151776-ms.

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Lohne, Arild y Ingebret Fjelde. "Surfactant Flooding in Heterogeneous Formations". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/154178-ms.

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Hou, Qingfeng, Youyi Zhu, Yousong Luo y Rui Weng. "Studies on Foam Flooding EOR Technique for Daqing Reservoirs After Polymer Flooding". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/151955-ms.

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Cubillos, Helber, Jesus Montes, Carlos Prieto y Pedro Romero. "Assessment of Foam for GOR Control to Optimize Miscible Gas Injection Recovery". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/152113-ms.

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Shahverdi, Hamidreza y Mehran Sohrabi. "Three-Phase Relative Permeability and Hystresis Model for Simulation of Water Alternating Gas (WAG) Injection". En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/152218-ms.

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Parkhonyuk, Sergey, Dmitry Sergeevich Gromakovskiy, Kevin D. Mauth, Almaz Sadykov, Kevin Mullen, Bernhard R. Lungwitz, Philippe Enkababian, Oleg Sosenko y Alexandr Karpukhin. "Implementation of Relative Permeability Modifiers in Krasnoleninskoe Oil Field: Case Histories." En SPE Improved Oil Recovery Symposium. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/152410-ms.

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Informes sobre el tema "Improved recovery"

Gabitto, Jorge y Kishore K. Mohanty. Surfactant-Polymer Interaction for Improved Oil Recovery. Office of Scientific and Technical Information (OSTI), enero de 2002. http://dx.doi.org/10.2172/789941.

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Larry A. Carrell. Improved Recovery Demonstration for Williston Basin Carbonates. Office of Scientific and Technical Information (OSTI), diciembre de 1997. http://dx.doi.org/10.2172/1641.

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Schenewerk, P. Improved recovery from Gulf of Mexico reservoirs. Office of Scientific and Technical Information (OSTI), julio de 1995. http://dx.doi.org/10.2172/100168.

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Hildebrandt, A., J. McDonald, E. Claridge y J. Killough. A field laboratory for improved oil recovery. Office of Scientific and Technical Information (OSTI), septiembre de 1992. http://dx.doi.org/10.2172/7103780.

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Unknown. SURFACTANT - POLYMER INTERACTION FOR IMPROVED OIL RECOVERY. Office of Scientific and Technical Information (OSTI), septiembre de 1997. http://dx.doi.org/10.2172/766780.

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Unknown. SURFACTANT - POLYMER INTERACTION FOR IMPROVED OIL RECOVERY. Office of Scientific and Technical Information (OSTI), octubre de 1998. http://dx.doi.org/10.2172/766781.

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Llave, F., B. Gall y H. ,. Scott, L. ,. Cook, I. Gao. Chemical systems for improved oil recovery: Phase behavior, oil recovery, and mobility control studies. Office of Scientific and Technical Information (OSTI), septiembre de 1995. http://dx.doi.org/10.2172/105030.

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Burdis, Mark y Neil Sbar. Recovery Act: Electrochromic Glazing Technology: Improved Performance, Lower Price. Office of Scientific and Technical Information (OSTI), junio de 2012. http://dx.doi.org/10.2172/1111422.

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Sippel, M. A. Improved recovery demonstration for Williston Basin carbonates. Final report. Office of Scientific and Technical Information (OSTI), julio de 1998. http://dx.doi.org/10.2172/290885.

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Ling, Kegang, Zhengwen Zeng, Jun He, Peng Pei, Xuejun Zhou, Hong Liu, Luke Huang et al. Geomechanical Study of Bakken Formation for Improved Oil Recovery. Office of Scientific and Technical Information (OSTI), diciembre de 2013. http://dx.doi.org/10.2172/1155006.

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