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Tesis sobre el tema "Immune response"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

Nissinen, A. (Antti). "Humoral immune response to phosphatidylethanol." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295232.

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Abstract Heavy alcohol consumption places a substantial burden on health all over the world. Metabolites of alcohol evoke alterations that lead to tissue damage in many organs. Phosphatidylethanol (PEth) is a unique phospholipid formed in the cellular membranes during the metabolism of ethanol after alcohol consumption. PEth has attracted special attention as it is postulated to be a reliable marker of long term heavy alcohol consumption. The aims of present study were to investigate the immunogenicity of phosphatidylethanol in mice and to analyze the plasma antibodies binding to phosphatidyle

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2

De, Oliveira O. L. P. "Immune response to Thy-1." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484410.

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3

Baldwin, Lisa Michelle. "The immune response to biomaterials." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420298.

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4

Brown, Anna. "The immune response to salmomellae." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292915.

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5

Flynn, Karen Mildred Ryan 1969. "GP96 and the immune response." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8586.

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6

Yang, Jun. "Immune response to orthopaedic biomaterials." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1058195837.

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7

Solinas, Cinzia. "Immune response in breast cancer." Doctoral thesis, Universite Libre de Bruxelles, 2019. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/282008.

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The immunogenicity of breast cancer (BC) is quite heterogeneous among the clinical subtypes, with immune responses identified most frequently in triple negative (TNBC) and HER2-positive tumors. The extent, spatial localization, distribution patterns, organization and phenotype of the BC immune infiltrate are currently being widely investigated but require standardization before they can be used clinically. One highly relevant unmet clinical need is to understand how immune features are linked to prognosis and potential benefit from treatments, particularly immunotherapy. The present work inves

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8

Díaz, de Ståhl Teresita. "Fcγ Receptors in the Immune Response". Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1545.

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<p>Circulating immune complexes play an important role in the modulation of antibody responses and in the pathogenesis of immune diseases. This thesis deals with the <i>in vivo </i>regulatory properties of antibodies and their specific Fc receptors.</p><p>The immunosuppressive function of IgG is used clinically, to prevent rhesus-negative women from becoming sensitized to rhesus-positive erythrocytes from the fetus. The mechanism behind this regulation is poorly understood but involvement of a receptor for IgG, FcγRII, has been suggested. It is shown in this thesis that IgG and also IgE induce

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9

Ågren, Karin. "Immune response in human tonsil tissue /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2714-6.

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10

O'Rourke, Sara Marie. "The cytotoxic immune response to HBV." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297231.

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11

Lira, Arman. "The Immune Response in Parkinson's Disease." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30515.

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Microglia activity has been detected in Parkinson’s disease (PD) post-mortem brains and experimental animal models; however the precise interplay between microglia and dopamine neurons of the SNpc is not well understood. In the blood plasma of PD patients, our laboratory found elevated levels of interferon-gamma (IFN-γ), a proinflammatory cytokine and potent activator of microglia. Given this, we sought to untangle the immune responses relevant to PD in mice, examining IFN-γ’s involvement and signaling mechanism using an inflammatory co-culture model of microglia and midbrain neurons treated

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12

Aldred, Patricia M. R. "Variation in human immune response genes." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415720.

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13

Remes, Andrew David. "On the immune response to biomaterials." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291433.

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14

Sponaas, A.-M. "Immune response to minor H-antigens." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381669.

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15

Kar, Satwik. "Innate immune response to respiratory viruses." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/73374/.

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The innate immune system has a variety of ways of recognizing infection from pathogens such as viruses and bacteria. One of its first lines of defence is to detect Pattern Associated Molecular Patterns (PAMPs) using Pattern Recognition Receptors (PRRs) such as the Toll-Like Receptors (TLRs), the RIG-Like Helicases (RLHs) and the Nod-Like Receptors (NLRs). These receptors recognize certain molecular structures from the pathogens and lead to first line of defence which includes increased cytokines and IFNs. This study delineate the human body’s innate immune responses to human respiratory viruse

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16

Parkes, Eileen. "The immune response to DNA damage." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709693.

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Breast cancer is a highly heterogenous disease and current methods of treatment selection in the clinic do not take account of this heterogeneity. In order to improve outcomes in breast cancer, a personalised approach is required. Previously we identifed a DNA damage response deficient (DDRD) molecular subgroup within breast cancer. A 44-gene expression assay prospectively identifying this subgroup was validated as predicting benefit from DNA-damaging chemotherapy. This subgroup was defined by interferon signalling. In this study the biology identified by the subgroup is addressed, identifying

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17

Olsen, Daniel S. "Nuclear BMP2 and the Immune Response." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4171.

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Nuclear bone morphogenetic protein 2 (nBMP2) is a nuclear variant of the secreted growth factor BMP2. Experiments in nBmp2NLStm mutant mice, which lack nBMP2 in the nucleus, have shown that nBMP2 affects intracellular calcium transport in skeletal muscle and hippocampal neurons. The objective of this study was to determine whether nBMP2 affects the immune system, since activation of lymphocytes and other immune cells depends on intracellular calcium transport. We found that spleens in nBmp2NLStm mutant mice were 24% smaller than in wild type mice. The white pulp of the spleen contains many imm

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18

SOARES, FILIPE JOEL FERNANDO. "IMMUNE RESPONSE IN DAIRY COW FORESTOMACHS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/548168.

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Production diseases of dairy cows include several pathologies. These are considered man-made problems, mostly reported in the post-calving period of negative energy balance (NEB), when high-yielding dairy cows are unable to achieve a feed energy intake matching their high production requirements (Mulligan et al., 2008). A correct management of production diseases demands an early diagnostic approach and prognostic parameters. In ruminants, metabolic stress greatly influences the forestomachs physiology, including their immune response ability. Therefore a proper evaluation of production disea

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19

Pitchai, Manju Sofia. "Harnessing the immune response to enhance osseointegration." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/418638.

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New understanding of immune system biology has led a paradigm shift in the development of biomaterials away from classically ‘inert’, to ‘immuno-modulatory’ biomaterials that have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. This project aims to examine macrophage behavior and in particular integrin expression at the cell–biomaterial interface in vitro, in order to delineate the underlying molecular events occurring during biomaterial-mediated osseous healin

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20

Wangkahart, Eakapol. "Immune responses of rainbow trout (Oncorhynchus mykiss) to vaccination and immune stimulation." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=233634.

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Vaccination and the use of immune stimulants are two important ways to mitigate the costs of disease in fish aquaculture. A vaccine to Enteric redmouth disease (ERM) was the first licensed fish vaccine in the world. Although effective in protecting fish from the motile bacterial (Yersinia ruckeri) infection, ERM can occur in ERM vaccinated fish due to the rise of non-motile Y. ruckeri that does not express flagellin. This highlighted the need for continual improvement of vaccine efficacy and the importance of flagellin in fish immune responses. In this thesis the immune response to the ERM vac

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21

Dahal, Lekh Nath. "Soluble CTLA-4 and immune regulation." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=202565.

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22

Buske-Kirschbaum, Angelika. "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135731.

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress m

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23

Rodgers, Angela. "Macrophage responses and their involvement in generating an immune response against tuberculosis." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406802.

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24

Buske-Kirschbaum, Angelika. "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27671.

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress m

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25

Vergara, Alert Júlia. "Immune response to influenza infection and vaccination." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/98472.

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Els virus de la influença tipus A (VIA) són patògens zoonòtics que poden infectar un ampli nombre d’hostes incloent-hi les aus, els porcs i els homes, entre altres. Anualment es documenten milions d’infeccions en humans causades per virus de la influença estacionals. Les pandemies causades pel virus influença també tenen una elevada repercussió pel que fa a la sanitat i l’economia. Tot i que determinats subtipus de VIA s’adapten millor en espècies d’aus que en humans, hi ha hagut casos d’infeccions en humans per virus de la influença de tipus aviars. La susceptibilitat dels porcs per infectar-

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26

Mandato, Craig Anthony. "Modulators of the insect cellular immune response." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ32841.pdf.

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27

Cheung, Ka-wa Benny. "Immune regulation in response to mycobacterial infection." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634206.

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28

Cheung, Ka-wa Benny, and 張嘉華. "Immune regulation in response to mycobacterial infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634206.

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29

Gallagher, Helen P. "The skin immune response to Malassezia furfur." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394764.

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30

Barclay, W. S. "The humoral immune response to rhinovirus infection." Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383380.

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31

Simmons, Ruth April. "Characterisation of the immune response to PARV4." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:85f81b48-d9ad-467e-a266-5d3b103798f4.

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PARV4 is a novel human parvovirus initially identified in an intravenous drug user at risk of HIV infection. PARV4 is a small single stranded DNA virus principally absent from the general population, but common in HCV- and HIV-infected individuals. Until 2009, most published PARV4 studies related to the prevalence of PARV4 in various risk groups. PARV4 has been detected in the liver of HCV-patients and the bone marrow of HIV-patients. Parvovirus B19, the closest related virus, elicits a strong immune response and can cause serious disease. Thus, this project was initiated to characterise the i

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32

Chaichanasiriwithaya, Wiwat. "Role of ehrlichial components in immune response /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu148794880758923.

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33

El, Chamy Laure. "New components of drosophila innate immune response." Strasbourg 1, 2008. http://www.theses.fr/2008STR13124.

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La réponse immunitaire de la Drosophile implique l’activation des voies de signalisations Toll et IMD contrôlant l’expression de gènes codant des peptides antimicrobiens. Ces deux voies présentent de fortes similarités avec les voies NF-kB régulant la réponse immunitaire innée chez les mammifères. Durant ma thèse, j’ai étudié les mécanismes d’activation de la voie Toll. Mon travail a mené à une nouvelle perception des mécanismes de reconnaissances impliquant la detection des activités microbiennes. J’ai également participé à l’identification de nouveaux composants des voies Toll et IMD. Grâce

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34

Anichini, Gabriele, and Maria Grazia Cusi. "Immune response analysis to Measles virus in subjects vaccinated with MMR vaccine and naturally infected subjects." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1183352.

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Measles virus belongs to the Morbillivirus genus, Paramixoviridae family. It is the causative agent of a highly contagious acute infective disease, typical of infancy, characterized by fever, skin rash, cough and conjunctivitis, and a generalized immune suppression (Griffin, 2013). The virus is transmitted through the respiratory tract, multiplicates in its upper part and in regional lymph nodes, thus resulting in lymphatic and hematic dissemination with appearance of first clinical signs after 9-19 days (de Vries et al., 2015). In 30% of the cases, complications in the lower respiratory tract

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35

Warnatsch, Annika. "Impact of proteasomal immune adaptation on the early immune response to viral infection." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16775.

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Im Kampf gegen eine Virusinfektion spielen CD8+ T Zellen des adaptiven Immunsystems eine besondere Rolle. Sie patroullieren im Körper und entdecken spezifische Virusepitope, welche mittels MHC Klasse I Molekülen auf der Oberfläche infizierter Zellen präsentiert werden. Wird eine virus-infizierte Zelle erkannt, kann diese schnell und effizient eliminiert. Für die Generierung viraler Peptide, welche auf MHC Klasse I Komplexe geladen werden, ist das Ubiquitin-Proteasom-System von essentieller Bedeutung. Kürzlich wurden weitere Funktionen des Immunoproteasoms aufgedeckt wie zum Beispiel der Schutz

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36

Urrutia, Alejandra. "Defining the boundaries of a healthy immune response using standardized immune monitoring tools." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066004/document.

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Le projet Milieu Intérieur a pour but d'identifier les facteurs génétiques et environnementaux ayant un impact sur la variabilité immunitaire naturelle. Cette analyse multiparamétrique requière néanmoins d'utiliser des outils standardisés. Afin d'étudier la réponse immune induite, nous avons utilisé un système optimisé prêt à l'emploi de stimulation du sang et développé un protocole unique de quantification de l'ARN afin d'étudier la signature transcriptionnelle en réponse à des immuno-modulateurs. Testant l'hypothèse que la réponse à des composés complexes peut être définie par la signature A

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37

Moro, Monica. "Manipulation of anti-tumour immune response by tumour targeting with soluble immuno-modulatory molecules." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323271.

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38

Ghaffari, Emma Louise Marie. "Early growth response genes -2 and -3 are essential for optimal immune responses." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/8134.

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Early Growth Response Genes (EGR) is a family of four transcription factors containing a unique zinc finger domain. EGR-2 and EGR-3 are important for hindbrain development and myelination. These transcription factors are also necessary for lymphocyte function however, the mechanisms are still unclear. Previous findings have shown that EGR-2cKO mice develop lupus-like autoimmune disease with high levels of pro-inflammatory cytokines despite showing normal T and B cell proliferation after mitogenic stimulation. Therefore we established the CD2-EGR-2-/-EGR-3-/- mouse model to explore the phenotyp

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39

Grainger, John Robert. "Immune modulation by parasitic nematodes." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3809.

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Almost 2 billion people world-wide are infected with parasitic helminths. These complex multicellular eukaryotic organisms are capable of establishing long-term infections even in the face of an intact immune response. Typically, in these settings regulatory components of the immune response, such as Foxp3+ T regulatory cells (Tregs), become dominant, limiting protective effector responses towards the parasite. Helminths are thought to have evolved mechanisms, including release of immunomodulatory molecules termed excretory-secretory products (ES), to sway the balance between the regulatory an

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40

Li, Chun-bong. "Mechanisms of HIV-1 Tat induced immune response." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31537169.

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41

Kummu, O. (Outi). "Humoral immune response to carbamyl-epitopes in atherosclerosis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526205670.

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Abstract Carbamylation of proteins in vivo occurs by cyanate, non-enzymatically when urea is dissociated, and by myeloperoxidase-catalyzed oxidation from thiocyanate. Carbamylation of low-density lipoprotein is suggested to enhance atherogenesis in patients with with chronic kidney disease and uremia. This thesis study assessed the questions of whether healthy humans or uremic patients under enhanced carbamylation have antibodies recognizing carbamyl-epitopes in plasma, and what is their role in vivo. Also, humoral immune response to carbamyl-LDL immunization and its impact on atherogenesis in

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42

Buisseret, Laurence. "Clinical significance of immune response in breast cancer." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/259895.

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La présence d’une immunité anti-tumorale est maintenant bien établie et ce, y compris dans le cancer du sein pourtant considéré comme peu immunogénique. Cette notion a été récemment renforcée dans différentes études qui ont mis en évidence une corrélation entre la présence d’un infiltrat immun au niveau des cancers du sein primaires et le pronostic des patientes. La réponse immune anti-tumorale n’est cependant pas assez efficace pour contrôler la survenue du cancer. En effet, différents mécanismes sont utilisés par les cellules tumorales pour échapper au système immunitaire comme l’expression

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43

Saleh, Nadeh S., and n/a. "Characterisation of the immune response in otitis media." University of Canberra. Applied Science, 2002. http://erl.canberra.edu.au./public/adt-AUC20061107.163007.

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Acute otitis media is the most common illness diagnosed during early childhood that can cause significant morbidity (Brook, 1994) and sometimes can cause irreversible sequelae such as a hearing defect and subsequent learning difficulties (Klein, 1994). The aims of the research presented here were to study some aspects of the middle ear defence mechanisms in both immune and non-immune rats following experimental otitis media (OM) with two pathogens nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (M. catarrhalis). This study also aimed at developing a suitable technique for p

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44

Wen, Sicheng. "The mucosal immune response against Helicobacter pylori infection /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-033-6/.

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45

Bersztel, Adam. "Modulation of the Immune Response in Concordant Xenotransplantation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3396.

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46

Ali, Qasim. "Contribution to the mathematical modeling of immune response." Phd thesis, Ecole Nationale Supérieure des Mines de Saint-Etienne, 2013. http://tel.archives-ouvertes.fr/tel-00905603.

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The early steps of activation are crucial in deciding the fate of T-cells leading to the proliferation. These steps strongly depend on the initial conditions, especially the avidity of the T-cell receptor for the specific ligand and the concentration of this ligand. The recognition induces a rapid decrease of membrane TCR-CD3 complexes inside the T-cell, then the up-regulation of CD25 and then CD25-IL2 binding which down-regulates into the T-cell. This process can be monitored by flow cytometry technique. We propose several models based on the level of complexity by using population balance mo

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47

Ali, Munaf. "The humoral immune response to SIV recombinant antigens." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243412.

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48

McDouall, Rhoda Mary. "Immune response to cardiac endothelial cells following transplantation." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369250.

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49

Allgrove, Judith E. "Factors influencing the mucosal immune response to exercise." Thesis, Loughborough University, 2007. https://dspace.lboro.ac.uk/2134/12325.

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Despite the abundance of research conducted into the effects of exercise on mucosal immunity the results remain controversial. Much of the inconsistencies arise from the exercise protocols, the participants studied and their nutritional status, as well as methodological and analytical differences. The purpose of this thesis was to examine the influence of some of these factors, and to investigate potential means of enhancing the mucosal immune response to exercise. In study 1 (Chapter 3) it was shown that a fed or fasted state 2 h prior to exercise had no effect on the s-IgA concentration or s

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50

McGowan, Sheila Anne. "Modulation of the immune response by imino sugars." Thesis, University of Strathclyde, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501808.

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Imino sugars are carbohydrate-like alkaloids largely characterised over the last ten years that function as glycosidase inhibitors as they mimic the sugar moiety of the natural substrate. They have been reported to have immunomodulatory activity and the purpose of this study was to identify and characterise such activity. The ability of over sixty imino sugars to modify macrophage/dendritic cell cytokine production was analysed. The immunomodulatory activity of two imino sugars MNLP 462a and MNLP 24 with pro-inflammatory activity was studied in depth. They were found to upregulate in vitro mac

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