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Kaválek, Jaromír, Ulrika Králíková, Vladimír Macháček, Miloš Sedlák y Vojeslav Štěrba. "Kinetics and mechanism of solvolysis of N-aryl sulfuric diamides". Collection of Czechoslovak Chemical Communications 55, n.º 1 (1990): 202–22. http://dx.doi.org/10.1135/cccc19900202.
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The methanolysis and hydrolysis kinetics have been studied with the following sulfuric diamide derivatives: N-methyl-N-phenyl- (IIIa), N-methyl-N-(4-methoxycarbonylphenyl)- (IIIb), N-(4-methoxycarbonylphenyl)- (IIIc), N-methyl-N-(2-methoxycarbonylphenyl)- (IIId), N-(2-methoxycarbonylphenyl)- (IIIe), and N-methyl-N-(2,4-dibromophenyl)- (IIIf). The solvolyses of the neutral substrates IIIa and IIIb proceed by the addition-elimination mechanism. In the presence of the solvent lyate ions the solvolyses go by the E1cb mechanism. The solvolyses of the conjugated bases of compounds IIIa and IIIb are subject to general acid catalysis, the effects of the ring substituents being opposite to those in the addition-elimination mechanism. The solvolyses of compounds IIId and IIIf exhibit a distinct catalytic effect of neighbouring group; the reaction goes via a reactive intermediate, the transformation of the intermediate into the solvolysis product being subject to general acid and base catalysis.
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Rayaji, A. y A. H. M. Viswanatha Swamy. "IN VIVO AND IN VITRO EVALUATION OF ANTI-CANCER ACTIVITY OF NEWLY SYNTHESIZED COBALT COMPLEX OF COUMARIN SCHIFF BASES". INDIAN DRUGS 54, n.º 04 (28 de abril de 2017): 61–69. http://dx.doi.org/10.53879/id.54.04.10792.
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Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocytes. Modern treatment of cancer includes chemotherapy, hormone therapy, radiotherapy and surgery but they are associated with several adverse effects such as alopecia, fatigue and general weakening of the body’s immune system due to bone marrow suppression. However, there is a continual need to look out for newer drugs to overcome the menace of cancer. In view of this we synthesized the new Coumarin-Cobalt complex derivatives. Structures of all the newly synthesized metal complexes are supported by Spectral data such as IR, NMR, and mass spectrometry. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity by in vivo anticancer activity (BrdU estimation). Immunohistochemical analysis has been done by BrdU and the synthesized compounds were screened for anti-oxidant activity and in vitro HepG2 cell lines. The IC50 values of the HepG2 cell lines as compared with that of standard Cisplatin and compounds IIIb, IIId, IIIe, IIIh and IIIj showed appreciable activity at a concentration less than 10 μG. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity. Anti-oxidant activity performed by Nitric oxide reducing ability, Superoxide dismutase and reducing activity:Compounds IIIc, IIIe and IIIg showed appreciable activity at 400μg/mL and 800 μg/mL screened by nitric oxide reducing ability, superoxide anion was effectively scavenged by compound IIIg at 400μg/mL and 800 μg/mL and reducing power of compounds IIIc and IIIj is comparable with standard ascorbic acid at concentrations 400μg/mL and 800 μg/mL.
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Ayanwale, Musa Adekunle. "Calibration of Polytomous Response Mathematics Achievement Test Using Generalized Partial Credit Model of Item Response Theory". EDUCATUM Journal Of Science, Mathematics And Technology 8, n.º 1 (4 de junio de 2021): 57–69. http://dx.doi.org/10.37134/ejsmt.vol8.1.7.2021.
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This study assessed the empirical comparability of item calibration in the developed essay (DEVessay-MAT) iand (NECOessay-MAT) iimathematics iiachievement iitest iiunder iithe iiGeneralized iiPartial iiCredit iiModel i(GPCM). The iiiinstrumentation iiiresearch iiiapproach iiiof iiicounterbalance iiidesign iiiwas iiiemployed. iiiThe iiisample consisted iiiof iii1080 iiisenior iiisecondary iiischool iiistudents iii(SSS3) iiiof iii36 iiischools, iiiwho iiiwere drawn randomly iiifrom iiiOsun iiiEast iiisenatorial iiidistrict iiiof iiiOsun iiiState, iiiNigeria. iiiTwo iiiinstruments iiiwere used iiiand iiidata iiiobtained iiiwere iiisubjected iiito iiiParallel iiiAnalysis iii(PA), iiiGeneralized iiiPartial iiiCredit Model iii(GPCM) iiiand iiiIndependent iiisample iiit-test. iiiResults iiishowed iiithat iiithe iiitest iiidoes iiinot violate unidimensionality iiiwith iiithe iiifirst iiiEigenvalue iii(2.05) iiifrom iiithe iiiexperimental iiidata iiiwas iiigreater than iiithe iiifirst iiirandom iiiEigenvalue iii(1.17) iiifrom iiiPA, iiiwhile iiiother iiiEigenvalues iiifrom iiithe experimental iiidata iiiwere iiiless iiithan iiithe iiirest iiiof iiiEigenvalues iiiunder iiiPA. iiiAlso, iiithere iiiexisted iiia significant iiidifference iiibetween iiithe iiistep iiidifficulties/overall iiiitem iiidifficulty iiiand iiidiscrimination/slope index iiiof iiithe iiitwo iiiinstruments iiiwith iii(t iii= iii3.52, iiidf iii= iii8, iiip iii< iii0.05) iiiand iii(t iii= iii3.26, iiidf = iii8, iiip iii< iii0.05) iiirespectively. iiiThe iiiauthor iiiconcluded iiithat iiithe iiideveloped iiiessay iiitest produced better iiiitem iiistatistics iiiestimates iiicompared iiito iiiNECO-MAT iii(essay) iiitest. iiiConsequently, iiiit iiiwas recommended iiithat iiipublic iiiexamining iiibodies iiiin iiisub-Sahara iiiAfrica iiishould iiiembrace iiian iiiapt polytomous iiimodel iiifor iiithe iicalibration iiof itheir itest items.
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Zykova, S. S., K. V. Namyatova, K. L. Gankova, E. A. Lystsova, T. V. Shavrina y S. N. Shurov. "Antihypoxic Activity of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2<i>H</i>-pyrido[4,3,2-<i>de</i>]quinnolin-3-ones". Drug development & registration 11, n.º 4 (23 de diciembre de 2022): 22–26. http://dx.doi.org/10.33380/2305-2066-2022-11-4(1)-22-26.
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Introduction. The state of hypoxia, causing damage and cell death, underlies many pathological processes. In addition, hypoxia induces a state of free radical oxidation, which enhances the damaging effect of hypoxic damage. This necessitates the synthesis of new compounds and the creation on their basis of drugs with antihypoxic activity.Aim. The aim of this study is the synthesis and study of the antihypoxic activity of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2Н-pyrido[4,3,2-de] quinnolin-3-ones.Materials and methods. Compounds of the 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2H-pyrido[4,3,2-de]quinnolin-3-ones series were obtained as a result of the interaction of 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids c o-tolyl-, p-tolyl-, p-fluoro-, p-nitro-, 2,4,6-trichlorophenylhydrazines. As a result, 10 substances were synthesized, the structure of which was confirmed by IR and 1H NMR spectroscopy. The study of the antihypoxic activity of the obtained compounds was carried out using the method of normobaric hypoxia with hypercapnia («hypoxia in a jar»).Results and discussion. The studied compounds have different effects on the lifespan of mice under conditions of acute normobaric hypoxia with hypercapnia. Compounds IIIi and IIId, respectively, increased the lifespan of mice most significantly by 26.36 % and 25.64 %, respectively, compounds IIIa, IIIb, IIIg were less significant, compounds IIIc and IIIf had no effect, and compound IIIj had a prohypoxic effect.Conclusion. Compounds with the most pronounced antihypoxic and antioxidant properties have been identified. Thus, further synthesis and study of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2H-pyrido[4,3,2-de]cinnolin-3-ones is reasonable.
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Siddiqui, Muhammad y Courtney Dorroll. "IIIT Intellectual Panels". American Journal of Islam and Society 31, n.º 4 (1 de octubre de 2014): 154–58. http://dx.doi.org/10.35632/ajis.v31i4.1084.
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The International Institute of Islamic Thought (IIIT) organized a two-day seriesof intellectual panels at the Islamic Society of North America’s 51st annualconvention, held in Detroit during August 30-31 2014. These events werehosted in the institute’s hospitality suite on the third floor of the Cobo Center.
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Elaradi, Hadeel. "IIIT Intellectual Panels". American Journal of Islam and Society 34, n.º 2 (1 de abril de 2017): 139–43. http://dx.doi.org/10.35632/ajis.v34i2.875.
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The International Institute of Islamic Thought (IIIT) held a series of panels atthe 42st annual convention of the Islamic Circle of North America-MuslimAmerican Society (ICNA-MAS) in Baltimore, MD, on Saturday, April 15,2017. This year, the convention’s theme was “The Quest for True Success:The Divine Message of Moses, Jesus, and Muhammad.”IIIT’s intellectual panels dealt with a variety of topics. The first session,“The Concept of Madrasa: Context and Reform,” revolved around EbrahimMoosa’s What Is a Madrasa? (Chapel Hill: University of North CarolinaPress, 2015). Moosa (professor, Islamic studies, University of Notre Dame)reminisced about his time as a madrasa student in India, stating: “The way Icame into India was in a very pietistic orientation, that Islam was all about piety. India and the madrasas taught me that Islam is about thinking ... piety... goodness ... making a contribution to the world.” However, he continued,the “madrasas have done a good job in preserving the identity of traditionalIslam, but it’s unable to make that identity actually work in the real world. ...and that modern knowledge has been closed off from the lived experience ofMuslims.” ...
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Hützler, Wilhelm Maximilian y Ernst Egert. "N—H...S and N—H...O hydrogen bonds: `pure' and `mixed'R22(8) patterns in the crystal structures of eight 2-thiouracil derivatives". Acta Crystallographica Section C Structural Chemistry 70, n.º 2 (31 de enero de 2014): 241–49. http://dx.doi.org/10.1107/s2053229614001387.
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The preferred hydrogen-bonding patterns in the crystal structures of 5-propyl-2-thiouracil, C7H10N2OS, (I), 5-methoxy-2-thiouracil, C5H6N2O2S, (II), 5-methoxy-2-thiouracil–N,N-dimethylacetamide (1/1), C5H6N2O2S·C4H9NO, (IIa), 5,6-dimethyl-2-thiouracil, C6H8N2OS, (III), 5,6-dimethyl-2-thiouracil–1-methylpyrrolidin-2-one (1/1), C6H8N2OS·C5H9NO, (IIIa), 5,6-dimethyl-2-thiouracil–N,N-dimethylformamide (2/1), 2C6H8N2OS·C3H7NO, (IIIb), 5,6-dimethyl-2-thiouracil–N,N-dimethylacetamide (2/1), 2C6H8N2OS·C4H9NO, (IIIc), and 5,6-dimethyl-2-thiouracil–dimethyl sulfoxide (2/1), 2C6H8N2OS·C2H6OS, (IIId), were analysed. All eight structures containR22(8) patterns. In (II), (IIa), (III) and (IIIa), they are formed by two N—H...S hydrogen bonds, and in (I) by alternating pairs of N—H...S and N—H...O hydrogen bonds. In contrast, the structures of (IIIb), (IIIc) and (IIId) contain `mixed'R22(8) patterns with one N—H...S and one N—H...O hydrogen bond, as well asR22(8) motifs with two N—H...O hydrogen bonds.
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Slavík, Jiří, Vladimír Hanuš y Leonora Slavíková. "Alkaloids from Stylophorum lasiocarpum (OLIV.) FEDDE". Collection of Czechoslovak Chemical Communications 56, n.º 5 (1991): 1116–22. http://dx.doi.org/10.1135/cccc19911116.
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From the underground part of Stylophorum lasiocarpum (OLIV.) FEDDE (0.58% alkaloids) (-)-stylopine and coptisine (as chloride IIa) were isolated as the principal alkaloids. Smaller quantities of sanguinarine, macarpine, chelerythrine, chelirubine, chelilutine (as the respective chlorides IIIa, IIIb, IIIc, IIId, IIIe) protopine, corysamine (as chloride IIb), berberine (as chloride IIc) and (-)-trans-N-methylstylopinium hydroxide (as iodide IVa) were also isolated. Chromatographically were detected small amounts of chelidonine, allocryptopine, cryptopine, scoulerine, isoboldine, magnoflorine and salt of cis-N-methylstylopinium. The aerial part (0.16% alkaloids) afforded (-)-stylopine, coptisine and (+)-chelidonine as dominant alkaloids and small amounts of protopine and (-)-cis-N-methylstylopinium hydroxide (as iodide IVb).Chromatography proved negligible amounts of sanguinarine, chelirubine, cryptopine, scoulerine, isoboldine, corytuberine, corysamine, berberine, magnoflorine and trans-N-methylstylopinium iodide. The so far undescribed 8-methoxydihydromacarpine (VIb) was prepared.
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Pervez, Saulat. "The International Institute of Islamic Thought Intellectual Panels". American Journal of Islam and Society 33, n.º 3 (1 de julio de 2016): 157–61. http://dx.doi.org/10.35632/ajis.v33i3.933.
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The International Institute of Islamic Thought (IIIT) held a series of panels atthe 41st annual convention of the Islamic Circle of North America (ICNA) inBaltimore, MD, on Sunday, May 29, 2016.The first panel, “Maqāṣid al-Sharī‘ah as a Philosophy of Islamic Law,”featured Jasser Auda (Al-Shatibi Chair of Maqasid Studies, the InternationalPeace College, South Africa) and Ebrahim Rasool (Distinguished Scholar inResidence at Georgetown University’s Edmund A. Walsh School for ForeignService and former ambassador of South Africa to the U.S.), with ErminSinanović (director, Research and Academic Programs, IIIT) as moderator.Sinanović began by introducing IIIT to the diverse audience. He explainedthat the institute is devoted to the revival of Islamic traditions and the reformof Muslim societies. In addition to affirming that our sources and principlesare unchangeable, he positioned IIIT as the institution dedicated to making our intellectual legacy the core of the solution to our current malaise, for it is the“answer to the crisis of the ummah,” a crisis that is largely intellectual in nature:our inability to translate our eternal message as per our time and space ...
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Pervez, Saulat. "IIIT Panels at the 2015 ICNA Convention". American Journal of Islam and Society 32, n.º 3 (1 de julio de 2015): 149–51. http://dx.doi.org/10.35632/ajis.v32i3.1002.
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The International Institute of Islamic Thought (IIIT) hosted two consecutivepanels at the annual Islamic Circle of North America (ICNA) convention onMay 24, 2015.Ermin Sinanović (director, Research and Academic Programs) openedpanel 1, “Imam & Community Education,” by explaining that IIIT is committedto continuous professional development for imams and community leadersso that they can be effective in the United States. As opposed to the societiesfrom which they come, here they are expected to perform many non-traditionalroles, such as Islamic instruction, interfaith participation, counseling, dealingwith a pluralistic community, and catering to the community’s needs. All ofthese expectations and the difficulties that imams face in trying to fulfill them,he remarked, “explains the high turnover we have at mosques.”Several years ago, IIIT and Hartford Seminary designed a joint GraduateCertificate in Imam and Muslim Community Leadership program to trainimams in the necessary skills. To “bring the Muslim component to the conversationand instill self-respect and confidence in their students,” IIIT helpedHartford Seminary hire Muslim instructors. Each applicant for this 24-hourcredit eight-course program must already possess a BA. The certification providespractical training for counseling in hospitals, prisons, and other settings.Zahid Bukhari (former president, ICNA) acknowledged the huge variationamong imams, especially those “imported imams” who have soundknowledge of Islam but cannot relate to American culture and youth and thusend up essentially leading disconnected lives “in an icloud type atmosphere.”He recommended periodic recertification of imams and community leadersso that they can improve their ability to handle contemporary challenges, andexpressed enthusiasm for the ICNA-IIIT partnership.Timur Yuskaev (director, Graduate Certificate Program in Imam and MuslimCommunity Leadership, Hartford Seminary) commented that many ...
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Khalil, Nancy A. "Reflections on Political Islam". American Journal of Islam and Society 33, n.º 1 (1 de enero de 2016): 163–64. http://dx.doi.org/10.35632/ajis.v33i1.897.
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The International Institute of Islamic Thought (IIIT) participated in the annualmeeting of the American Academy of Religion (AAR) in Atlanta, GA, heldNovember 21-24, 2015. In addition to the participation of staff and associatesin several meeting events and panels, IIIT maintained a book booth in the ExhibitHall, co-organized a panel on “Opportunities and Challenges of TeachingIslamic Studies in Theological Seminaries,” and held its second annual AARReception and Special Lecture.Offering a tribute to Ismail al-Faruqi (d. 1986), IIIT co-founder and cofounderof the AAR’s “Study of Islam” section, Abubaker Alshingieti (executivedirector, IIIT) and Ermin Sinanović (director of research, IIIT) expressedgreat pride in rekindling a stronger IIIT presence at the AAR by reviving thehistorical link established by al-Faruqi. Fittingly, John Esposito (GeorgetownUniversity), al-Faruqi’s first doctoral advisee, delivered the keynote speech:“Reflections on Political Islam: Concepts and Contexts.”An intellectual giant in his own right, Esposito presented a historicalanalysis of the rise of political Islam movements during the latter half of thetwentieth century through his individual interactions, appointments, and presencein spaces of influence at critical times. His keynote speech served bothas an intellectual analysis as well as a personal journey, full of spontaneouslysprinkled firsthand stories and narratives from private conversations. He emphasizedthe critical need to avoid ahistoric analyses of such movements andto resist symptomatic treatments that have become a popular approach bywestern governments blind to their own roles in such undesired behaviors andviolence.Referring to challenges like ISIS and youth radicalization, Esposito statedthat “unless you understand the context within which political Islam arose...:who were the players, what were the issues for these movements, and alsowhat their interactions were with government, you can’t understand why wecontinue to screw up today.” Making specific reference to recent governmentinitiatives on Countering Violent Extremism that are youth-centric and targetthe great role religion occupies in people’s lives, he reminded the audiencethat discounting a history of oppression by western-backed authoritarianregimes is a myopic perspective to the rise of radicalism.His speech spanned over fifty years of political history and Americaninvolvement in Muslim-majority nations with an emphasis on the Iranian ...
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Willoughby, Jay. "IIIT Intellectual Panels at the ISNA 50th Annual Convention". American Journal of Islam and Society 31, n.º 1 (1 de enero de 2014): 155–61. http://dx.doi.org/10.35632/ajis.v31i1.1033.
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The International Institute of Islamic Thought (IIIT) organized a two-day seriesof intellectual panels at the Islamic Society of North America’s (ISNA) 50thannual convention, held in Washington, DC, over the Labor Day weekend(Aug. 31–Sept. 1, 2103). These events were hosted in the institute’s hospitalitysuite on the main floor of the Washington Convention Center. Recently publishedIIIT books and other selected publications were prominently displayed.A documentary on IIIT and its goals was shown before each session.
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Klásek, Antonín, Stanislav Kafka y Thomas Kappe. "Synthesis and Some Reactions of 3-Substituted 1,4-Bis(4-hydroxy-2-oxo-1,2-dihydroquinolin-6-yloxy)butanes". Collection of Czechoslovak Chemical Communications 60, n.º 12 (1995): 2137–46. http://dx.doi.org/10.1135/cccc19952137.
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Condensations of 1,4-bis(4-aminophenoxy)butane Ia and its N,N'-dimethyl derivative Ib with substituted diethyl malonates gave 1,4-bis(4-hydroxy-2-oxo-1,2-dihydroquinolin-6-yloxy)butanes IIa-IIf. From these compounds, 1,4-bis(3-halogeno-2,4-dioxo-1,2,3,4-tetrahydroquinolin-6-ylox y)butanes IIIa-IIIg and 1,4-bis(3-hydroxy-2,4-dioxo-1,2,3,4-tetrahydroquinolin-6-yloxy )butanes IIIh-IIIm were prepared.
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Černý, Ivan, Vladimír Pouzar, Pavel Drašar y Miroslav Havel. "β-Glucosides of steroidal unsaturated nitriles". Collection of Czechoslovak Chemical Communications 52, n.º 10 (1987): 2521–33. http://dx.doi.org/10.1135/cccc19872521.
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Reaction of 3β-methoxymethoxy-5-pregnen-20-one (Ia) with diethyl cyanomethylphosphonate and subsequent removal of the protecting group afforded (20E)-3β-hydroxy-24-norchola-5,20(22)-diene-23-nitrile (IIIa). Besides the analogous derivative IIIb with another double bond in position 14, the fully saturated compounds IIIc and IIId with configuration 5α and 5β, respectively, were prepared similarly. Silver silicate-catalyzed glycosylation of IIIa-IIId with tetra-O-acetyl-α-D-glucopyranosyl bromide gave β-D-glucopyranosides IVa-IVd in 77-89% yield. A parallel series of hemisuccinates VIa-VId was prepared in 64-81% yields by reaction of IIIa-IIId with 2-(trimethylsilyl)ethyl hydrogen butanedioate followed by deblocking with tetrabutylammonium fluoride. The glucoside IVa was prepared also by an alternative reaction pathway starting from 3β-hydroxy-5-pregnen-20-one (VIII). Compound VIII was converted in 80% yield into the glucoside IX which, after protection as the tetra-O-(trimethylsilyl)derivative XII, was treated with diethyl cyanomethylphosphonate.
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Willoughby, Jay. "Theologies and Ethics of Justice". American Journal of Islam and Society 34, n.º 4 (1 de octubre de 2017): 132–37. http://dx.doi.org/10.35632/ajis.v34i4.809.
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The Summer Institute for Scholars 2017, held at the IIIT headquarters inHerndon, VA, from July 26-29, brought together a group of scholars to address“Theologies and Ethics of Justice: New Directions for Islamic Thoughtin the 21st Century.” To present as many of their ideas as possible, the widerangingand thought-provoking comments of the chairs and discussants arenot recountedThe event began with welcoming remarks by Ermin Sinanović (programdirector and director of research, IIIT), Abubaker al-Shingieti (executive director,IIIT) and Hisham Altalib (president, IIIT). The participating scholars,students, and special guests were introduced and viewed a film on IIIT.The special panel on “Justice in Islamic Thought” was addressed byRamon Harvey (Ebrahim College, London) and Jonathan A.C. Brown(Georgetown University; via Skype). Ramon Harvey’s paper, “The Qur’anand the Just Society: An Enquiry into Scriptural Theology, Ethics, andHermeneutics,” introduced the theoretical framework of his forthcomingbook, The Qur’an and the Just Society. He presented the basic underlyingenquiry: the search for the meaning of societal justice within the Qur’anicworldview. His argument proceeded in three steps: (1) justice in the Qur’anmust be situated within the broader “moral narrative” about the spiritualjourney of souls and societies and from which an implicit moral theologycan be detected; (2) that it is possible to build on such Qur’anic indicationsto articulate a theological and ethical system that models it; and (3) that sucha system gives a meaningful epistemological foundation for a hermeneuticsto discover the Qur’an’s basic principles of justice when contextualizedwithin the initial Muslim community led by Prophet Muhammad ...
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Jurášek, Adolf, Vladimír Žvak, Jaroslav Kováč, Oľga Rajniaková y Jarmila Štetinová. "Synthesis and reactions of β-substituted derivatives of furan". Collection of Czechoslovak Chemical Communications 50, n.º 9 (1985): 2077–83. http://dx.doi.org/10.1135/cccc19852077.
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The 1,4-cycloaddition reaction of 4-phenyl-1,3-oxazole to 2-propinyl benzoate and dimethyl butinedioate afforded the respective 3-furylmethyl benzoate (I) and 3,4-bis(methoxycarbonyl)furan (II). These compounds served for the synthesis of 3-chloromethylfuran and 3,4-bis(chloromethyl)furan, which afforded via Wittig reaction 3-(β-arylvinyl)furans III (aryl = 5-nitro-2-furyl (IIIa), 5-nitro-2-thienyl (IIIb), 1-methyl-4-nitro-2-pyrrolyl (IIIc), and 4-nitrophenyl (IIIe)) and 3,4-bis(β-arylvinyl)furans IV (aryl = 5-nitrofuryl (IVa), 5-nitro-2-thienyl (IVc), and 4-nitrophenyl (IVd)). According to spectral evidence (1H NMR, IR, UV spectra), compound IIIa and IIIb originated as E isomers, whilst the remaining products are a mixture of E and Z isomers; some couples were succeded to separate.
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Elaradi, Hadeel. "IIIT Panels at the 2016 ISNA Convention". American Journal of Islam and Society 33, n.º 4 (1 de octubre de 2016): 160–65. http://dx.doi.org/10.35632/ajis.v33i4.949.
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Slouka, Jan y Vojtěch Bekárek. "Synthesis and cyclization of some N-oxides of 2-pyridylhydrazones of mesoxalic acid derivatives". Collection of Czechoslovak Chemical Communications 53, n.º 3 (1988): 626–32. http://dx.doi.org/10.1135/cccc19880626.
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Coupling of diazotized 2-aminopyridine-1-oxide with ethyl cyanoacetylcarbamate, cyanoacetamide, malononitrile, and 2-benzimidazolylacetonitrile in an acid medium afforded N-oxides of the corresponding 2-pyridylhydrazones Ia-Id, which also exist in the N-hydroxyazine tautomeric forms IIa-IId as confirmed by IR spectroscopy. Hydrazone Ia was thermally cyclized to give 2-(pyridine-1-oxide-2-yl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (IIIa) which was converted into the corresponding thioamide IIIb, acid IIIc, and amidoxime IIId.
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Willoughby, Jay. "IIIT Intellectual Panels at the ISNA 49th Annual Convention". American Journal of Islam and Society 30, n.º 1 (1 de enero de 2013): 144–52. http://dx.doi.org/10.35632/ajis.v30i1.1172.
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The International Institute of Islamic Thought (IIIT) organized a two-day seriesof intellectual panels at the Islamic Society of North America’s (ISNA)49th annual convention, held in Washington, DC over the Labor Day weekend.These events, hosted in the institute’s hospitality suite on the main floorof the Washington Convention Center, took place during 1-2 September 2012.Recently published IIIT books and other selected Arabic and English publications,as well as special collections of the late Ismail Al Faruqi’s works andmany of Ali Mazrui’s books, journal articles, and personal items, were alsoprominently displayed. At the beginning of each session, a documentary onIIIT and its goals was shown ...
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Elaradi, Hadeel. "IIIT Panels at the 2016 ISNA Convention". American Journal of Islamic Social Sciences 33, n.º 4 (octubre de 2016): 160–65. http://dx.doi.org/10.12816/0037491.
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Eulitz, M., C. Murphy, D. T. Weiss y A. Solomon. "Serologic and chemical differentiation of human lambda III light chain variable regions." Journal of Immunology 146, n.º 9 (1 de mayo de 1991): 3091–96. http://dx.doi.org/10.4049/jimmunol.146.9.3091.
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Abstract Human lambda L chains of a major V lambda subgroup, V lambda III, have been differentiated serologically and chemically into three V lambda III sub-subgroups designated V lambda IIIa, V lambda IIIb, and V lambda IIIc. Antisera prepared against lambda III Bence Jones proteins were obtained that recognized distinctive V lambda III-related epitopes expressed by monoclonal lambda III L chains. After appropriate absorption, these reagents were rendered specific for three distinct populations of lambda III proteins--lambda IIIa, lambda IIIb, and lambda IIIc. The antisera were used in comparative immunodiffusion analyses of 28 monoclonal lambda III L chains, 10 of which were classified as lambda IIIa, 4 as lambda IIIb, and 14 as lambda IIIc. The isotypic nature of the three lambda III sub-subgroups was demonstrated serologically through analyses of lambda-chains derived from the serum IgG molecules of normal individuals. The amino acid sequences of five serologically classified lambda III chains, which included members of the three V lambda III sub-subgroups, had been previously determined. This information, in addition to our establishment of the complete (or virtually complete) V region sequence of 15 and the partial sequence of eight other lambda IIIa, lambda IIIb, and lambda IIIc proteins, made it possible to correlate chemical data with serologic classification. Proteins within each of the three serologically-classified lambda III sub-subgroups typically possessed a high degree (approximately 83%) of intra-sub-subgroup sequence homology that included both framework and complementarity determining region residues. Furthermore, within the framework and complementarity determining regions, sub-subgroup-specific residues were identified. Taken together, these data reveal that the human V lambda III genome consists of (at least) three distinct V lambda IIIa, V lambda IIIb, and V lambda IIIc germline genes that encode for lambda IIIa, lambda IIIb, and lambda IIIc L chains, respectively.
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Rádl, Stanislav, Lenka Kovářová y Jiří Holoubek. "Synthesis and antibacterial activity of some 1-(2-propynyl) and 1-propadienyl derivatives of 1,4-dihydro-4-oxoquinoline-3-carboxylic acids and similar heterocycles". Collection of Czechoslovak Chemical Communications 56, n.º 2 (1991): 439–48. http://dx.doi.org/10.1135/cccc19910439.
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N-Alkylation of IIIa, IIIb, IIId - IIIf and 9-acridanone with 3-bromopropyne in dimethyl sulfoxide in the presence of potassium carbonate yielded N-(2-propynyl) derivatives IVa - IVe and VIa, respectively. Ethyl esters IVa, IVb, and IVe were hydrolyzed to IVf - IVh, respectively. Compounds IVf, IVg, IVctreated with bases yielded N-propadienyl derivatives Va - Vc. On the other hand 2-substituted compounds IVd and IVh did not change under the same conditions. Compound VIa treated with powdered potassium hydroxide in dimethyl sulfoxide at room temperature yielded N-(1-propynyl) derivative VII.
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Čolić, Ahmed. "Teaching Children: A Moral, Spiritual and Holistic Approach to Educational Development". Context: Journal of Interdisciplinary Studies 8, n.º 2 (10 de marzo de 2022): 159–63. http://dx.doi.org/10.55425/23036966.2021.8.2.159.
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Siddiqui, Anees A., Asif Husain, M. Shaharyar, Mohd Rashid, Ravinesh Mishra, Jaseela Majeed y Bhawana Sati. "SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES". SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 18, n.º 18 (20 de diciembre de 2010): 11–18. http://dx.doi.org/10.48141/sbjchem.v18.n18.2010.15_2010.pdf.
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1,3,4-oxadiazoles are important because of its versatile biological actions. In the present study, several 2-(quinoline-8-yloxymethyl)-5-aryl-1,3,4-oxadiazole derivates (IIIa-j) have been synthesized by the condensation of 8-hydroxy quinoline acetyl hydrazide (II) with various aromatic acids in presence of phosphorous oxychloride. The structures of the newly synthesized compounds have been established on the basis of elemental analysis, UV, IR, and 1H NMR spectral data. The synthesized compounds were screened for their in vitro growth-inhibiting activity against different strains of bacteria and fungi viz., S aureus, E. Coli, P. aeruginosa, C. Albicans, A. flavus, and A. fumigates, and the results were compared with the standard such as Ampicillin (50µg/ml) using agar diffusion technique. Compounds IIIc and IIIf were found to be equipotent as ampicillin when tested against the strains of E.Coli where as tested compounds IIIc, IIIf and IIIi showed good antibacterial and antifungal activity when tested against the strains of S. aureus, P. aeruginosa, and C. Albicans.
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Sechler, Jan L., Hongwei Rao, Anne Marie Cumiskey, Irbert Vega-Colón, Michael S. Smith, Takatoshi Murata y Jean E. Schwarzbauer. "A novel fibronectin binding site required for fibronectin fibril growth during matrix assembly". Journal of Cell Biology 154, n.º 5 (3 de septiembre de 2001): 1081–88. http://dx.doi.org/10.1083/jcb.200102034.
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Fibronectin (FN) assembly into a fibrillar extracellular matrix is a stepwise process requiring participation from multiple FN domains. Fibril formation is regulated in part by segments within the first seven type III repeats (III1–7). To define the specific function(s) of this region, recombinant FNs (recFNs) containing an overlapping set of deletions were tested for the ability to assemble into fibrils. Surprisingly, recFN lacking type III repeat III1 (FNΔIII1), which contains a cryptic FN binding site and has been suggested to be essential for fibril assembly, formed a matrix identical in all respects to a native FN matrix. Similarly, displacement of the cell binding domain in repeats III9–10 to a position close to the NH2-terminal assembly domain, as well as a large deletion spanning repeats III4–7, had no effect on assembly. In contrast, two deletions that included repeat III2, ΔIII1–2 and ΔIII2–5, caused significant reductions in fibril elongation, although binding of FN to the cell surface and initiation of assembly still proceeded. Using individual repeats in binding assays, we show that III2 but not III1 contains an FN binding site. Thus, these results pinpoint repeat III2 as an important module for FN–FN interactions during fibril growth.
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Červená, Irena, Jiří Holubek, Emil Svátek, Jan Metyš y Miroslav Protiva. "Potential antidepressants: 2-(Aminoalkoxy)biphenyls and some related ω-substituted 2-alkoxybiphenyls". Collection of Czechoslovak Chemical Communications 54, n.º 7 (1989): 1966–78. http://dx.doi.org/10.1135/cccc19891966.
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Reactions of 2-hydroxybiphenyl with α,ω-dibromoalkanes gave the 2-(bromoalkoxy)biphenyls IIIa-IIId. The 2-(dimethylaminoalkoxy)biphenyls VIa and VIb were transformed via carbamates VIIa and VIIb to the secondary amines Va and Vb. Their homologues Vc and Vd were obtained from the bromo compounds IIIc and IIId by treatment with methylamine. Bromo compounds IIIa and IIIb were reacted with 1-methylpiperazine, 2-(1-piperazinyl)ethanol, 3-(1-piperazinyl)propanol, and 4-amino-1-benzylpiperidine and gave the diamines VIIIa, VIIIb, IXa, Xa, Xb, and XIa. Addition of 2-hydroxybiphenyl to acrylonitrile afforded the nitrile XIIa. The homologous nitrile XIIb was obtained from the bromo compound IIIb and sodium cyanide in dimethyl sulfoxide. Nitriles XIIa and XIIb were reduced with aluminium hydride to diamines IVb and IVc. The nitriles were also transformed to hydrochlorides of the corresponding ethyl imidates XIVa and XIVb. Their hydrolysis resulted in the esters XVa and XVb. The acid XIIIa was obtained by acid hydrolysis of the nitrile XIIa; the acid XIIIb resulted from the acid hydrolysis of the ester XVb. The imidate XIVb was transformed to the amidine XVIb and to the dihydroimidazole XVIIb. Only the amine Vc showed properties indicative of potential antidepressant.
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Ye, Tianwen, Aimin Chen, Wen Yuan y Sanhuai Gou. "Management of Grade III Open Dislocated Ankle Fractures". Journal of the American Podiatric Medical Association 101, n.º 4 (1 de julio de 2011): 307–15. http://dx.doi.org/10.7547/1010307.
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Background: Isolated dislocation of the ankle with grade III open fracture has been scarcely reported. These ankle injuries usually involved mortise fractures, complete dislocation of the tibial astragaloid joint, capsuloligamentous structure disruption, and severe soft-tissue damage. There is no well-recognized regimen that would result in desirable outcomes. Methods: Sixteen patients with grade III open dislocated ankle fractures were treated immediately with bioabsorbable implants and an external fixator between January 2003 and June 2007. According to the classification system of Gustilo and Anderson, five patients were grade IIIA, seven were grade IIIB, and four were grade IIIC. Surgical interventions included combined internal fixation with bioabsorbable screws/rods and external fixation. Results: Patients underwent clinical and radiologic examination at an average of 18.1 months after surgery. Outcomes were excellent in seven patients (three IIIA, three IIIB, and one IIIC), good in four (one IIIA, two IIIB, and one IIIC), fair in three (one IIIA, one IIIB, and one IIIC), and poor in two (one IIIB, and one IIIC). In the two patients with poor outcomes, bone defect and cartilage exfoliating in the distal tibia were found during surgery. Painful osteoarthritis in the ankle was discovered 2 years after surgery. Another case had pin tract infections in the external fixator 3 months after surgery. There was no case of late deep infection. Conclusions: It may be a reasonable and desirable option that bioabsorbable implants combined with an external fixator be applied for treatment of severe open dislocated ankle fractures. (J Am Podiatr Med Assoc 101(4): 307–315, 2011)
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Rádl, Stanislav y Pavel Hradil. "Synthesis of some 1-alkyl-1,4-dihydro-4-oxo-1,7-naphthyridine-3-carboxylic acids". Collection of Czechoslovak Chemical Communications 56, n.º 11 (1991): 2420–29. http://dx.doi.org/10.1135/cccc19912420.
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Reaction of substituted 2-aminopyridines IIIa, IIIb, IIIe, and IIIf with ethyl ethoxymethylene malonate provided corresponding pyridylaminomethylenemalonates Va-Vd, respectively. Thermal cyclization of Va, Vc, and Vd yielded substituted ethyl 4-hydroxy-1,7-naphthyridine-3-carboxylates VIa, VIc, and VId. Compounds VIc and VId treated with morpholine gave 8-morpholino derivatives VIe and VIf. These compounds were ethylated to mixtures of N-ethylated (VIIa, VIIb) and O-ethylated products (VIIIa, VIIIb). Compound VIIIb was also prepared from ethyl 4-chloro-6-fluoro-8-morpholino-1,7-naphthyridine-3-carboxylate VIIIc and sodium ethanolate. Esters VIIa and VIIb were hydrolyzed under acidic conditions to the respective acids VIIc and VIId.
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Mervat Mohammed K y Tagreed N-A Omar. "Synthesis, Characterization, Anti-Inflammatory, and Antimicrobial Evaluation of New 2-Pyrazolines Derivatives Derived from Guaiacol". Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, Suppl. (4 de noviembre de 2023): 254–61. http://dx.doi.org/10.31351/vol32isssuppl.pp254-261.
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Abstract:
Chalcones were used to synthesis series of 2-pyrazoline derivatives and evaluated their antimicrobial and anti-inflammatory activities
(E)-1,3-diphenylprop-2-en-1-one (1-5) were synthesized by Claisen-Schmidt Condensation method through the reaction of acetophenone with five various para substituted benzaldehyde in presence of KOH, the reaction monitoring by TLC and the result intermediates were checked by melting point and FT-IR
Various 2-Pyrazoline derivatives were prepared by one pot reaction that involved the refluxing of (E)-1,3-diphenylprop-2-en-1-one (1–5) and Hydrazine monohydrate in the presence of glacial acetic acid for 24 hours at a temperature of (45–50) °C for a duration 24 hrs. pyrazoline II (1-5) was formed, then antioxidant compound (guaiacol) was added reflex for 24-48 hours, monitoring by TLC to ensure the reaction was completed. The final mixture was cooled in ice-water bathe until the formation of crystals were completed, added to crushed ice, kept in refrigerator overnight, filter, recrystallized and then dried to get 2-pyrazoline derivatives, IIIa, IIIb, IIIc, IIId and, IIIe. based on the spectral data 2-pyrazoline derivatives structures have been confirmed. The synthesized compounds were screened for their antimicrobial activity and anti-inflammatory.
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Willoughby, Jay. "IIIT-FCNA Fiqh Forum on Adoption and Orphan Care". American Journal of Islam and Society 34, n.º 2 (1 de abril de 2017): 135–39. http://dx.doi.org/10.35632/ajis.v34i2.874.
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On April 13, 2017, the International Institute of Islamic Thought (IIIT) andthe Fiqh Council of North America (FCNA) brought jurists, scholars, and professionalsin the field to share their latest research on the topic of adoptionand orphan care. The day-long forum, held at the IIIT headquarters in Herndon,VA, featured one concept paper and five panels.The opening session featured Zainab Alwani (vice chair, FCNA; programdirector, Fiqh Forum on Adoption and Orphan Care; founding director, Islamicstudies, Howard University School of Divinity), who spoke on “Orphan Carein the Qur’an and Sunnah: Critical Reading on Adoption and Kafala.” Statingthat she is providing a framework – not a solution – grounded in the Qur’anand Sunnah, she discussed why the number of orphans and abandoned childrenhas reached an all-time high; why Muslim Americans are reluctant toadopt them; and such concerns as the un-Islamic nature of the American legalsystem and the ensuring legal, cultural, and linguistic problems. She stressedthat taking care of these children is an ethical/moral issue and reminded theaudience of the biographies of Musa, Yusuf, Muhammad, and Maryam, all ofwhom were raised by people who were not their biological parents, and theimportance of the family structure. In closing, she recommended that Muslimsrevive the collective spirit of caring for orphans, work with lawyers to deriveSharia-compliant solutions, integrate these children into our communities, andreconsider some traditional fiqhī concepts (e.g., brother and mawlā). AbubakerAl-Shingieti (executive director, IIIT) chaired.Panel 1, “Voices from the Field,” opened with Ranya Shbeib (co-founder,Muslim Foster Care Association; https://www.muslimfostercare.org), who focusedon meeting orphans’ immediate needs and provide family support. Herorganization works hard to achieve these twin goals and to raise local communityawareness by a four-step process: making a presentation, providingthe relevant orientation, giving practical training, and actually receiving thechild. After each step, unfortunately, the number of interested people declines ...
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Subramanian, G. y A. Vijaya. "Iterative Intensity Integration Technique (IIIT) for contouring reflective surfaces". Optics and Lasers in Engineering 93 (junio de 2017): 92–99. http://dx.doi.org/10.1016/j.optlaseng.2017.01.007.
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Mengi, Gopal. "Four Years of Excellence: IIIT Delhi Empowers Future Technologists". XRDS: Crossroads, The ACM Magazine for Students 30, n.º 2 (diciembre de 2023): 12–13. http://dx.doi.org/10.1145/3637456.
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Sattar, Zaidi. "Report on the Third Seminar on Islamic Economics". American Journal of Islam and Society 8, n.º 1 (1 de marzo de 1991): 181–84. http://dx.doi.org/10.35632/ajis.v8i1.2656.
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The Third Seminar on Islamic Economics, held under the sponsorshipof the International Institute of Islamic Thought (IIIT) and the Associationof Muslim Social Scientists (AMSS), took on an international character withdelegates in attendance from as far east as Malaysia, Egypt, and Saudi Arabiain addition to participants from Canada and the United States. This year'stheme for the conference, "Resource Mobilization and Investment in an IslamicFramework;' evoked considerable interest among both academicians andpractitioners of the Islamic economic reform movement. Evidence of thisinterest was seen in the large number of research papers received on thesubject although, regrettably, funding limitations prevented many a scholarfrom participating in the meetings.The first day's sessions opened with brief remarks from Sayyid M. Syeed,general secretary of the AMSS, and Zaidi Sattar, program director for theseminar. Their remarks, while highlighting the significant strides made inthe past decade in research on Islamic economics, pointed to the substantialfinancial and logistical constraints that remain in the advancement of futureresearch in the area. IIIT and AMSS were commended for their past rolein this endeavor, and hopes were expressed for a more vigorous role in thefuture.The highlight of the opening session was the thoughtful inaugural addressby Taha Jabir al ‘Alwani, President, IIIT, who emphasized the importanceof the “human” element in the organization and management of economicresources as “. . . man is both intellect ready for thought, and hands readyfor action.” Citing from the Holy Qur’an and the works of Islamic scholars,he stressed that Islamic thought has much to offer in the emancipation ofthe ummah from the debilitating influence of colonialism. Development ofthe mind, he argued, is as critical to a society’s growth process as is thedevelopment of economic resources ...
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Pratheek, S., Sachin Manjunath, Saikiran M, Manoj Kumar y Darshan L. M. "Disguised Face Recognition using Deep Learning". International Journal for Research in Applied Science and Engineering Technology 11, n.º 5 (31 de mayo de 2023): 199–204. http://dx.doi.org/10.22214/ijraset.2023.51468.
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Abstract: The accuracy of facial recognition has significantly improved thanks to deep learning-based methods. However, several factors including facial ageing, disguises, and position fluctuations impair the efficiency of automatic face recognition algorithms. Disguises are commonly utilized to conceal one's identity or assume the identity of someone else by intentionally or unintentionally altering one's facial features. Here, we intend to make use of the Disguised Faces in the Wild (DFW) small-scale training data. Deep Convolutional Neural Networks(DCNNs) will be trained for general face recognition. The IIIIT-D testing data set will be used for model evaluation because it exhibits greater performance. The IIIT-D testing dataset is used to gauge the effectiveness of the model's performance when applied to faces that have been deliberately disguised. The performance of the results is encouraging and suggests that DCNNs have a chance of successfully recognizing disguised faces.
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Willoughby, Jay. "The Relationship between the Qur’an and the Sunnah". American Journal of Islam and Society 27, n.º 4 (1 de octubre de 2010): 153–55. http://dx.doi.org/10.35632/ajis.v27i4.1304.
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From 25 July to 6 August 2010, a select group of scholars invited by the InternationalInstitute of Islamic Thought (IIIT) analyzed “The Relationshipbetween the Qur’an and the Sunnah.” Chaired by Mahmoud Ayoub (HartfordSeminary), this twenty-session event focused on how Muslims are dealingwith Islam’s two core sources in the twenty-first century
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Kadiri, Sudarsana Reddy y Paavo Alku. "Subjective Evaluation of Basic Emotions from Audio–Visual Data". Sensors 22, n.º 13 (29 de junio de 2022): 4931. http://dx.doi.org/10.3390/s22134931.
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Understanding of the perception of emotions or affective states in humans is important to develop emotion-aware systems that work in realistic scenarios. In this paper, the perception of emotions in naturalistic human interaction (audio–visual data) is studied using perceptual evaluation. For this purpose, a naturalistic audio–visual emotion database collected from TV broadcasts such as soap-operas and movies, called the IIIT-H Audio–Visual Emotion (IIIT-H AVE) database, is used. The database consists of audio-alone, video-alone, and audio–visual data in English. Using data of all three modes, perceptual tests are conducted for four basic emotions (angry, happy, neutral, and sad) based on category labeling and for two dimensions, namely arousal (active or passive) and valence (positive or negative), based on dimensional labeling. The results indicated that the participants’ perception of emotions was remarkably different between the audio-alone, video-alone, and audio–video data. This finding emphasizes the importance of emotion-specific features compared to commonly used features in the development of emotion-aware systems.
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Willoughby, Jay. "Good Governance in Islam". American Journal of Islam and Society 29, n.º 4 (1 de octubre de 2012): 148–57. http://dx.doi.org/10.35632/ajis.v29i4.1192.
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The Summer Institute for Scholars 2012, held at the IIIT headquarters in Herndon,VA, from July 9-18, 2012, brought together twenty scholars to address“Good Governance in Islam: Classical and Contemporary Approaches.” Inorder to present as many of their ideas as possible, the wide-ranging andthought-provoking comments of the chairs and the discussants are not recountedhere ...
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Willoughby, Jay. "Islamic Law and Ethics". American Journal of Islam and Society 31, n.º 4 (1 de octubre de 2014): 149–54. http://dx.doi.org/10.35632/ajis.v31i4.1083.
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The Summer Institute for Scholars 2014, held at the IIIT headquarters in Herndon,VA, from June 16-21, 2014, brought together a group of scholars to address“Islamic Law and Ethics.” In order to present as many of their ideas aspossible, the wide-ranging and thought-provoking comments of the chairs andthe discussants are not recounted here.
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Willoughby, Jay. "Islamic Thought and Secular Modernity". American Journal of Islam and Society 33, n.º 4 (1 de octubre de 2016): 154–59. http://dx.doi.org/10.35632/ajis.v33i4.948.
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The Summer Institute for Scholars 2016, held at the IIIT headquarters in Herndon,VA, from August 8-13, 2016, brought together a group of scholars to address“Islamic Thought and Secular Modernity.” In order to present as manyof their ideas as possible, the wide-ranging and thought-provoking commentsof the chairs and the discussants are not recounted here.
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Dede Komarudin, Febri Hidayat y Dwi Kurniayu Putri. "Analisis Kadar Cemaran Logam Berat Timbal (Pb) dan Kadmium (Cd) Pada Air Tanah Di Perumahan Perumnas Bekasi". ISTA Online Technologi Journal 2, n.º 1 (22 de febrero de 2021): 8–13. http://dx.doi.org/10.62702/ion.v2i1.32.
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Abstrak Air sumur dapat tercemar oleh limbah rumah tangga, seperti baterai dan cat. Baterai dan cat termasuk limbah B3 (Bahan Berbahaya dan Beracun) karena mengandung berbagai macam logam berat seperti timbal dan kadmium. Baterai dan cat yang dibuang sembarangan kandungan logam berat dapat mencemari air tanah penduduk. Tujuan penelitian ini yaitu untuk mengetahui kadar logam kadmium (Cd) dan timbal (Pb). Sampel air tanah telah diambil dari 9 titik pada perumahan Perumnas I, Perumnas II, dan Perumnas III. Pengambilan sampel dilakukan pada bulan April 2018, diukur parameter logam di Laboratorium Pengujian dan Kalibrasi Balai Laboratorium Kesehatan Yogyakarta menggunakan Spektrofotometer Serapan Atom (SSA). Hasilnya adalah kadar Cd pada titik IA 0,0028 mg/L, IB 0,0047 mg/L, IC 0,0051 mg/L, IIA 0,0056 mg/L, IIB 0,0035 mg/L, IIC 0,0055 mg/L, IIIA 0,0061 mg/L, IIIB 0,0051 mg/L, dan titik IIIC 0,0027 mg/L. Kadar Pb pada titik IA 0,0264 mg/L, IB 0,0443 mg/L, IC 0,0509 mg/L, IIA 0,0453 mg/L, IIB 0,0362 mg/L, IIC 0,0457 mg/L, IIIA 0,0061 mg/L, IIIB 0,0051 mg/L, dan titik IIIC 0,0027 mg/L. Kadar logam Cd yang melebihi ambang batas berdasarkan Permenkes RI No 32 Tahun 2017 terdapat pada titik IC, titik IIA, titik IIC, titik IIIA dan titik IIIB. Kadar logam Pb yang melebihi ambang batas berdasarkan Permenkes RI No 32 Tahun 2017 terdapat pada titik IC dan titik IIIA. Abstract Dug Well is a ground water source used by local people and might to contaminated by local housewaste like chemical batery and wall liquid paint. Liquid paint and chemical batery are dangerous material and poisonous. Those material contains dangerous metal like cadmium and plumbum. Groundwater might be contaminated liquid paint and chemical battery, if not processed correctly. The aims study was identification and determination levels Plumbum (Pb) and Cadmium (Cd), Sample taken from 9 different places (Perumnas 1, perumnas 2, perumnas 3) at April 2018, Samples tested in Laboratorium Pengujian dan Kalibrasi BalaiLaboratoriumKesehatan Yogyakarta with method was Atomic Absorption Spectroscopy (AAS). The result was Cadmium levels at point IA 0.0028 mg/L, IB 0.0047 mg/L, IC 0.0051 mg/L, IIA 0.0056 mg/L, IIB 0.0035 mg/L, IIC 0.0055 mg/L, IIIA 0.0061 mg/L, IIIB 0.0051 mg/L, and point IIIC 0.0027 mg/L. Plumbum levels at point IA 0.0264 mg/L, IB 0.0443 mg/L, IC 0.0509 mg/L, IIA 0.0453 mg/L, IIB 0.0362 mg/L, IIC 0.0457 mg/L, IIIA 0.0061 mg/L, IIIB 0.0051 mg/L, and point IIIC 0.0027 mg/L. Contains Cadmium metal in dangerous level based on Permenkes RI no 32 2017. First samples IC, IIA, IIC, IIIA and IIIB. Based on the samples, sample number IC and IIIA have the most highPlumbum (Pb) contamination level.
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Gordienko, D. I., A. V. Skoroglyadov, E. A. Litvina, V. A. Mitish, D. I. Gordienko, A. V. Skoroglyadov, E. A. Litvina y V. A. Mitish. "Treatment of Open Crus Fractures". N.N. Priorov Journal of Traumatology and Orthopedics 10, n.º 3 (15 de septiembre de 2003): 75–78. http://dx.doi.org/10.17816/vto200310375-78.
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Results of treatment of 112 patients were analyzed. All patients were treated at the Moscow Clinical Hospital named after N.l. Pirogov during the period from 1998 to 2002. Fifty-four patients had I and 11 type, 38 - IIIA, 14 - IIIB and 6 patients - IIIC type of fractures by Gustilo classification. Tactics of treatment was defined by patient's general condition and the degree of soft tissue injury. In fractures of I and II type primary UTN osteosynthesis was preferable; in fractures of IIIA type primary osteosynthesis with AO rod device or Piless device followed by final UTN osteosynthesis were performed. In fractures of IIIB type osteosynthesis was carried out using device. To all patients with fractures of IIIC type the limb amputation was performed. Healing by first intention took place in fractures of I and II type. In fractures of IIIA and IIIB type the open management of wound with following closure during sequential debridement was preferred. When tibia necrosis developed, the resection in fractures zone with following early defect substitution by IHzarov technique was carried out.
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Willoughby, Jay. "Constitutions and Pluralism in Muslim States and Societies". American Journal of Islam and Society 32, n.º 4 (1 de octubre de 2015): 153–58. http://dx.doi.org/10.35632/ajis.v32i4.1017.
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The Summer Institute for Scholars 2015, held at the IIIT headquarters in Herndon,VA, from June 8-21, brought together a group of scholars to address“Constitutions and Pluralism in Muslim States and Societies.” In order to presentas many of their ideas as possible, the wide-ranging and thought-provokingcomments of the chairs and the discussants are not recounted here ...
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Kallempudi, Goutham, Khurram Azeem Hashmi, Alain Pagani, Marcus Liwicki, Didier Stricker y Muhammad Zeshan Afzal. "Toward Semi-Supervised Graphical Object Detection in Document Images". Future Internet 14, n.º 6 (8 de junio de 2022): 176. http://dx.doi.org/10.3390/fi14060176.
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The graphical page object detection classifies and localizes objects such as Tables and Figures in a document. As deep learning techniques for object detection become increasingly successful, many supervised deep neural network-based methods have been introduced to recognize graphical objects in documents. However, these models necessitate a substantial amount of labeled data for the training process. This paper presents an end-to-end semi-supervised framework for graphical object detection in scanned document images to address this limitation. Our method is based on a recently proposed Soft Teacher mechanism that examines the effects of small percentage-labeled data on the classification and localization of graphical objects. On both the PubLayNet and the IIIT-AR-13K datasets, the proposed approach outperforms the supervised models by a significant margin in all labeling ratios (1%, 5%, and 10%). Furthermore, the 10% PubLayNet Soft Teacher model improves the average precision of Table, Figure, and List by +5.4,+1.2, and +3.2 points, respectively, with a similar total mAP as the Faster-RCNN baseline. Moreover, our model trained on 10% of IIIT-AR-13K labeled data beats the previous fully supervised method +4.5 points.
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Gunna, Sanjana, Rohit Saluja y Cheerakkuzhi Veluthemana Jawahar. "Improving Scene Text Recognition for Indian Languages with Transfer Learning and Font Diversity". Journal of Imaging 8, n.º 4 (23 de marzo de 2022): 86. http://dx.doi.org/10.3390/jimaging8040086.
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Reading Indian scene texts is complex due to the use of regional vocabulary, multiple fonts/scripts, and text size. This work investigates the significant differences in Indian and Latin Scene Text Recognition (STR) systems. Recent STR works rely on synthetic generators that involve diverse fonts to ensure robust reading solutions. We present utilizing additional non-Unicode fonts with generally employed Unicode fonts to cover font diversity in such synthesizers for Indian languages. We also perform experiments on transfer learning among six different Indian languages. Our transfer learning experiments on synthetic images with common backgrounds provide an exciting insight that Indian scripts can benefit from each other than from the extensive English datasets. Our evaluations for the real settings help us achieve significant improvements over previous methods on four Indian languages from standard datasets like IIIT-ILST, MLT-17, and the new dataset (we release) containing 440 scene images with 500 Gujarati and 2535 Tamil words. Further enriching the synthetic dataset with non-Unicode fonts and multiple augmentations helps us achieve a remarkable Word Recognition Rate gain of over 33% on the IIIT-ILST Hindi dataset. We also present the results of lexicon-based transcription approaches for all six languages.
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Hajek, Jaroslav, Jakub Cvek, Jana Jackaninova, Eva Skacelikova, Jan Krhut, Ondrej Havranek y David Feltl. "Is there an intermediate risk group of nonseminoma?" Journal of Clinical Oncology 31, n.º 6_suppl (20 de febrero de 2013): 323. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.323.
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323 Background: To evaluate predictive factors of testicular nonseminoma cancer. Methods: Between 2000 and 2012, 189 patients with testicular nonseminoma cancer were evaluated. Stages according to TNM classification were I, II, and III for 84 patients (60%), 49 (26%), and 56 (30%). The median age of the patients was 31 years (range 18-77 years). Treatment was based on orchiectomy plus chemotherapy (bleomycine/etoposide/cisplatin and vinblastine/ifosfamide/cisplatin) and retroperitoneal lymphadenectomy in residual disease. Treatment protocol was updated regularly according to international standards. Overall survival (OS) was evaluated according to the stage, Karnofsky index (KI), and dose intensity of chemotherapy with the Kaplan-Meier method at 5% significance level. Results: There was a significant difference between OS in patient with the different stages (log-rank test, p=0.000), however, detailed analysis revealed that there is significantly worse survival in stage IIIC only (10-years OS for IIIC vs. IIIA+B, 35% vs. 88%, p=0.001) while the difference among IIIB and lower stages was not significant (p=0.383) and 10-years OS was 94%. Dose intensity of chemotherapy proved to be a significant predictive factor for OS in stage IIIA+B patients. Patients with no dose reduction had a significantly higher OS than those with any kind of dose reduction (10-years OS 96% vs. 0%, log-rank test, p=0,000). In stage IIIC, however, the dose intensity had no influence on OS (log-rank test, p=0.167). Unlike dose intensity, in stage III disease KI had no prognostic significance for OS (KI<80 versus KI≥80, Log-rank test, p=0,627) and this is true both for stages IIIA+B and for stage IIIC. Conclusions: Standard of care in testicular nonseminoma cancer offers excellent prognosis with no significant differences in OS for good and intermediate risk groups. On the other hand, outcomes for stage IIIC are poor and further intensification of treatment is warranted. We have found no impact of performance status on OS neither for stage IIIA+IIIB nor stage IIIC. Reduction of chemotherapy dose has a negative impact on OS in patients with stage IIIA+IIIB and should be avoided if possible.
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Willoughby, Jay. "Reflections on the Aftermath of the Arab Spring". American Journal of Islam and Society 32, n.º 1 (1 de enero de 2015): 160–63. http://dx.doi.org/10.35632/ajis.v32i1.967.
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On November 18, 2014, Datuk Seri Anwar Ibrahim, founder and board member,IIIT; leader of the Malaysian opposition; and former deputy prime ministerof Malaysia, shared his “Reflections on the Aftermath of the Arab Spring” withthe general public at the IIIT headquarters in Herndon, VA.He opened with “O you who believe! Obey Allah and obey the Apostleand those in authority from among you” (Q. 4:59), which he considers one ofthe Qur’an’s “most used and abused verses.” In addition to being used to supportdemocracy, it is abused by many others to demand the masses’ supportfor dictators, authoritarian, and military junta rule regardless of how they aretreated. This verse also highlights an issue that has rocked the Arab world eversince December 17, 2010, when Tunisian street vendor Mohamed Bouazizi sethimself on fire to protest the continued abuse and harassment inflicted uponhim by the Tunisian police force: the issue of governmental legitimacy, whichis a problem in both the West and the Muslim world. Anwar stated that thegovernment must represent a majority consensus, respect some process (e.g.,democracy), and allow people the freedom of expression so that they can expresstheir support, disgust, or opposition.The Arabs’ demand for legitimate governance has been on the mind ofIIIT as well, for its leaders have spent the last decade addressing this concernfrom the point of view of the maqāṣid. Anwar traced this concern back to along-ago meeting when several of the IIIT founders were discussing why therewas no Muslim equivalent of the “Western canon,” the “Great Books,” a “greatintellectual tradition.” This was the start of an ongoing process to fill this gapin contemporary Muslim literature.The outbreak of Arab Spring clearly revealed that there is still a need todeal with ethics in governance, for lasting reform can only be actualized inthe form of systems. The ongoing abuse, corruption, repression, and brutalityinflicted upon the people by their own leaders is, according to him, something ...
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Ul Haq, Irfan. "The Twenty-Second Annual Conference of the AMSS". American Journal of Islam and Society 11, n.º 1 (1 de abril de 1994): 122–27. http://dx.doi.org/10.35632/ajis.v11i1.2462.
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The Twenty-Second Annual Conference of the Association of MuslimSocial Scientists (AMSS) was jointly organized by the Intemational Instituteof Islamic Thought (IIIT) and the AMSS and was held at the IIITpremises in Hemdon, VA. The open-theme conference featured eighteenpanels organized into fourtem sessions.The opening session consisted of the welcoming address by DilnawazSiddiqui, President (Clarion University of Pennsylvania, Clarion, PA), remarksby Mushtaqur Rahman, Conference Chairman (University of Iowa,Ames, IA), and the inaugural address of Taha al 'Alwani (President,IIIT). The second session, "Islamic Philosophy and Compamtive Approaches,"was chaired by Ja'afar Sheikh Idris (Institute of Islamic andArabic Sciences, Fairfax, VA). Presentations included "Islamic Theory ofKnowledge: A Reapptaisal" by Sirajul Husain (Islamic Research and DevelopmentCouncil, Cleveland, OH), "Islamization of the Creative Imaginationand Its Ramifications in the Visual Arts of Islam" by Halide A.Salam (Radford University, Radford, VA), and "The Concept of Free Willin the Comments of al Ash'ari, al Hilli, and Taftazani" by Anne E.Francisse (Seattle, WA).The third session had two concurrent panels: "Concept of Shzird andDemocracy in Islam," chaited by Mumtaz Ahmad (Hampton University,Hampton, VA) and "Culture and Communication," chaired by Ali Ramadan(IIIT). The first panel comprised Aziza a1 Hibri (University of Richmond,Richmond VA) and Ja'afar Shaikh Idris. Al Hibri pointed out thatshura (mutual consultation) is part of Islamic constitutional theory and reflectsthe divine dimension of an Islamic political framework-while democracyis one process of shzirti reflecting the human will in the politicalplane. Also featured was Hamid al-Ghazali (Islamic Center of Lawrence,Lawrence, MO), who gave a special report on the removal of an unjustleader from an Islamic institution that had been presented to the CircuitCourt of Jackson County, Missouri.The culture and communication panel had three presentors. ShamfRahman (Northern State Univedty, Aberdeen, SD) spoke on media typesand Muslim culture vis-8-vis Pakistani films and videos. Hussein Abiva(Chicago, IL) dealt with the role and importance of Sufi orders in Balkan ...
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Gorbunova, V. N. y N. V. Buchinskaya. "Lysosomal storage diseases. Mucopolysaccharidosis type III, sanfilippo syndrome". Pediatrician (St. Petersburg) 12, n.º 4 (13 de diciembre de 2021): 69–81. http://dx.doi.org/10.17816/ped12469-81.
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The review describes the clinical, biochemical and molecular genetic characteristics of autosomal recessive mucopolysaccharidosis type III, or Sanfilippo syndrome. This is a genetically heterogeneous group of rare, but similar in nature, diseases caused by a deficiency of one of the four lysosomal enzymes involved in the degradation of heparan sulfate. All types of mucopolysaccharidosis III are characterized by severe degeneration of the central nervous system in combination with mild somatic manifestations, which is explained by the accumulation of high concentrations of heparan sulfate in the lysosomes of various cells, including the central nervous system. The primary biochemical defect in the most common type of mucopolysaccharidosis IIIA, occurring with a frequency of 1 : 105 and presented in 60% of all cases of the disease, is heparan-N-sulfatase, or sulfamidase deficiency. Mucopolysaccharidosis IIIB type occurs twice less often and accounts for about 30% of all cases of Sanfilippo syndrome. It is caused by the presence of inactivating mutations in the lysosomal -N-acetylglucosaminidase gene. Mucopolysaccharidosis IIIC and IIID are 4% and 6%, and occur at frequencies of 0.7 and 1.0 : 106. Mucopolysaccharidosis IIIC is caused by inactivating mutations in the gene of membrane-bound lysosomal acetyl-CoA:-glucosaminid-N-acetyltransferase, or N-acetyltransferase. Mucopolysaccharidosis IIID is based on the deficiency of lysosomal N-acetylglucosamine-6-sulfatase. The role of experimental models in the study of the biochemical basis of the pathogenesis of Sanfilippo syndrome and the development of various therapeutic approaches are discussed. The possibility of neonatal screening, early diagnosis, prevention and pathogenetic therapy of these severe lysosomal diseases are considered. As an example, a clinical case of diagnosis and treatment of a child with type IIIB mucopolysaccharidosis is presented.
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Cormier, Janice N., Yan Xing, Meichun Ding, Scott B. Cantor, Kristi J. Salter, Jeffrey E. Lee, Paul F. Mansfield, Jeffrey E. Gershenwald y Merrick I. Ross. "Cost Effectiveness of Adjuvant Interferon in Node-Positive Melanoma". Journal of Clinical Oncology 25, n.º 17 (10 de junio de 2007): 2442–48. http://dx.doi.org/10.1200/jco.2007.10.7284.
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Purpose To assess the benefits of adjuvant high-dose interferon alfa (HDI) treatment for patients with high-risk melanoma. Methods We designed a decision-analytic probabilistic Markov model to simulate the natural history of patients with stage IIIA, IIIB, and IIIC melanoma and evaluate the outcomes with and without HDI treatment. Outcomes were in quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios (ICERs). Probability estimates and costs were derived from primary patient level data, while the efficacy of HDI and associated utilities were determined from published reports. The base-case analysis was a cohort of 50-year-old patients. Results HDI increased the median life expectancy in patients with stage III melanoma from 3.75 years in the observation cohort to 4.42 years in the HDI cohort. The difference in QALYs ranged from 0.31 years for stage IIIA patients to 0.60 years for stage IIIC patients treated with HDI. HDI was cost effective in patients with stage IIIB and IIIC melanoma, with ICERs of $95,304 and $76,068 per QALY gained, respectively. Using a threshold of $100,000 per QALY gained, HDI was cost effective for all stage III patients younger than 52 years. HDI was not cost effective for patients with stage IIIA disease and for subsets of patients older than 63 years with stage IIIB disease. Conclusion Our model demonstrates that the probability of HDI being cost effective varies substantially by melanoma substage. HDI showed the greatest benefit in terms of QALYs and was most cost effective in patients younger than 60 years with stage IIIC disease.
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Dash, Biswajit, Suvakanta Dash y Damiki Laloo. "DESIGN AND SYNTHESIS OF 4-SUBSTITUTED QUINAZOLINE DERIVATIVES FOR THEIR ANTICONVULSANT AND CNS DEPRESSANT ACTIVITIES". International Journal of Pharmacy and Pharmaceutical Sciences 9, n.º 1 (31 de diciembre de 2016): 165. http://dx.doi.org/10.22159/ijpps.2017v9i1.15492.
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<p><strong>Objective: </strong>The present work is designed to synthesise some isomeric new series of Quinazoline-4-one/4-thione derivatives, based on the pharmacophoric model of central nervous system (CNS) activity by structural modifications retaining the essential structural features for the activity and evaluated for their anticonvulsant and CNS depressant properties.</p><p><strong>Methods: </strong>A series of 7-chloro-3-[substituted (amino/phenylamino)]-2-phenyl quinazolin-4 (3H)-one/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were prepared. The reaction scheme proceeds through the intermediate 7-chloro-2-phenyl-4H-benzo[d] [1, 3] oxazin-4-one. The structures of the newly synthesised compounds were characterized from infrared (IR), <sup>1</sup>H nuclear magnetic resonance (NMR) and mass spectra (m/z) and elemental analysis. The anti-convulsant and CNS depressant activity were investigated by maximum electroshock (MES) seizure test and porsolt’s behavioural despair test (forced swimming) respectively. The rota-rod test was performed to assess any probable changes in motor coordination induced by the test compounds.</p><p><strong>Results: </strong>The physicochemical and spectroscopic data clearly confirmed the synthesis of quinazoline derivatives with a common skeleton. The synthesised compounds were evaluated for their anticonvulsant and CNS depressant properties. Among them, six compounds <strong>(IIc, </strong>IIg, IIj, IIIc, IIIg, IIIj) exhibited a good activity profile in CNS depressant activity. Five compounds (IIc, IIg, IIj, IIIg, IIIh) showed protection against MES-induced seizures.</p><p><strong>Conclusion: </strong>The Quinazoline derivatives obtained from this research work indicates that the methyl/methoxy group in phenyl ring, amine and thiourea substitution at 3<sup>rd</sup> position of quinazoline derivatives are essential for CNS depressant activity as well as anticonvulsant activity. Compounds IIc, IIg, IIj, IIIc, IIIg, IIIj, and IIIh were found to be a potent compound which may be effective as a potential source for the development of CNS depressant and anti-convulsant drugs with lesser side effects</p>