Libros sobre el tema "IGF Type 2"

Type 2 Diabetes is a chronic condition where the body becomes resistant to insulin or does not produce enough insulin, leading to elevated blood glucose levels. This article provides detailed information about Type 2 Diabetes, serving as a resource for patients, their loved ones, and the public. The article is organized into key sections, starting with an introduction to the disease and its types. It explores the risk factors and global prevalence of Type 2 Diabetes, followed by an explanation of its causes and symptoms. The article explores the pathophysiology of the disease, outlining how it affects the body, and discusses the various complications that can arise if it is not properly managed. The diagnosis section covers the tests and criteria used to identify the disease, while the treatment section explains lifestyle modifications, medications, and other management strategies. The article concludes with a discussion on the prognosis of living with Type 2 Diabetes. All information is presented in simple terms to ensure it is understandable for all readers.

This chapter deals with the case that the building at infinity of the Bruhat-Tits building Ξ‎ is a Moufang quadrangle of type E⁶, E₇, and E₈. It begins with a hypothesis that takes into account a quadratic space of type Eℓ for ℓ = 6, 7 or 8, K which is complete with respect to a discrete valuation, the two residues of Ξ‎, and the two root group sequences of a Moufang polygon. It then considers the case that Ξ‎ is an unramified quadrangle if the proposition δ‎Ψ‎ = 2 holds. It also explains two other propositions: Ξ‎ is a semi-ramified quadrangle if δ‎Λ‎ = 1 and δ‎Ψ‎ = 2 holds, and a ramified quadrangle if δ‎Λ‎ = δ‎Ψ‎ = 1 holds.

This chapter presents various results about quadratic forms of type F₄. The Moufang quadrangles of type F₄ were discovered in the course of carrying out the classification of Moufang polygons and gave rise to the notion of a quadratic form of type F₄. The chapter begins with the notation stating that a quadratic space Λ‎ = (K, L, q) is of type F₄ if char(K) = 2, q is anisotropic and: for some separable quadratic extension E/K with norm N; for some subfield F of K containing K² viewed as a vector space over K with respect to the scalar multiplication (t, s) ↦ t²s for all (t, s) ∈ K x F; and for some α‎ ∈ F* and some β‎ ∈ K*. The chapter also considers a number of propositions regarding quadratic spaces and discrete valuations.

This chapter deals with the case that the building at infinity of the Bruhat-Tits building Ξ‎ is a Moufang semi-ramified quadrangle of type E⁶, E₇ and E₈. The basic proposition is that Ξ‎ is a semi-ramified quadrangle if δ‎Λ‎ = 1 and δ‎Ψ‎ = 2 holds. The chapter first considers the theorem supposing that ℓ = 6, that δ‎Λ‎ = 1 and δ‎Ψ‎ = 2, and that the Moufang residues R0 and R1 are not both indifferent. This is followed by cases ℓ = 7 and ℓ = 8 as well as theorems concerning an anisotropic pseudo-quadratic space, a quaternion division algebra, standard involution, a proper involutory set, and isotropic and anisotropic quadratic spaces.

AbstractCryoglobulinaemia is characterized by the presence in the blood of proteins showing the that precipitate when serum is cooled. Clinically recognised cryoprecipitates are predominantly immunoglobulin-containing. In Type 1 cryoglobulinaemia, the precipitate is formed from a monoclonal paraprotein, usually IgG. In Type 2, a monoclonal IgM binds IgG to form a mixed precipitate. Type 3 cryoglobulins do not contain a monoclonal element.Type 1 cryoglobulins are a rare cause of renal disease, but cause a membranoproliferative glomerulonephritis (MPGN) with nephrotic syndrome and haematuria and usually with severe cutaneous involvement.Type 2 is most typically associated with renal disease, again characterized by MPGN and haematuria, with variable cutaneous signs and vasculitis in other organs. Many cases are associated with Hepatitis C virus (HCV) infection – but not all.Therapeutic approaches include optimal antiviral regimen, immunosuppressive therapy (corticosteroids, rituximab, and cytotoxic agents), and plasma exchange. Treatment of HCV-related mixed cryoglobulinaemia vasculitis should be adjusted according to the clinico-biological presentation.

Evolutionary biologists often use the language of intentional psychology in an extended or metaphorical sense. This is a symptom of agential thinking, the practice of invoking concepts such as interests, goals, and strategies in evolutionary analysis. Agential thinking comes in two types. In type 1, the agent with the goal is an evolved entity, typically an individual organism. In type 2, the agent is the evolutionary process itself, often personified as ‘mother nature’. Agential thinking of type 2 is misleading. That of type 1 is a valid expression of adaptationist assumptions, but it relies on a crucial presupposition. It presumes that the organism exhibits a unity-of-purpose, in that all of its evolved traits must contribute to a single overall goal. Where this unity fails to obtain, as for example if there is within-organism conflict, it becomes impossible to treat an organism as akin to a rational agent pursuing a goal.

Titles in the Core Text series take the reader straight to the heart of the subject, providing focused, concise, and reliable guides for students at all levels. This chapter discusses the types of harm to the claimant that are tortious if they are deliberate. These include assault, battery, false imprisonment, unlawful harassment, and invasion of privacy.

This chapter addresses the underlying causes, and potential remedies, of pandemic diabesity, a term coined to capture the expanse, and causal pathway, from excess body fat, to insulin resistance, to type 2 diabetes. The case is made that to be effective, clinical approaches must emphasize both prevention and holism, salient principles of integrative preventive medicine. More importantly, if lifestyle is the requisite medicine to alleviate this malady—and the case is made that it is—then the constraints of clinical encounters may constitute a spoon too small to deliver this medicine effectively and get it to go down universally. This chapter concludes with the proposition that lifestyle is the right medicine for obesity and type 2 diabetes alike, and that all of culture must be the spoon that delivers it. This, too, is concordant with an integrative perspective of care, and a focus on prevention.

The diagnosis of first-degree and third-degree atrioventricular (AV) block is straightforward but that of second-degree AV block is more involved. Type I block and type II second-degree AV block are electrocardiographic patterns that refer to the behaviour of the PR intervals (in sinus rhythm) in sequences (with at least two consecutive conducted PR intervals) where a single P wave fails to conduct to the ventricles. Type I second-degree AV block describes visible, differing, and generally decremental AV conduction. Type II second-degree AV block describes what appears to be an all-or-none conduction without visible changes in the AV conduction time before and after the blocked impulse. The diagnosis of type II block requires a stable sinus rate, an important criterion because a vagal surge (generally benign) can cause simultaneous sinus slowing and AV nodal block, which can resemble type II block. The diagnosis of type II block cannot be established if the first post-block P wave is followed by a shortened PR interval or by an undiscernible P wave. A narrow QRS type I block is almost always AV nodal, whereas a type I block with bundle branch block barring acute myocardial infarction is infranodal in 60–70% of cases. All correctly defined type II blocks are infranodal. A 2:1 AV block cannot be classified in terms of type I or type II block, but it can be AV nodal or infranodal. Concealed His bundle or ventricular extrasystoles may mimic both type I or type II block (pseudo-AV block), or both

This chapter discusses the legal nature of the claims process. Topics covered include the type of process; exclusivity of process; how substantive law, if any, is applied and whether procedural law at the place where the claims process is located applies; whether decisions made in the claims process are final and binding; whether decisions rendered in the claims process require approval of another body before becoming effective; whether there are any aspects of claims as to which decision-makers are mandated to follow and apply decisions by another body; and how decisions in the claims process are enforced. An Editors’ Commentary and separate Annotations show how each of these Mass Claims Processes has handled the matter.

♦ Upper cervical spine injuries should be considered in all blunt trauma patients.♦ Critical review of plain radiographs or CT should carefully examine the alignment of the articulations between the occiput-C1 and C1-2 to determine if ligamentous injury is present.♦ The initial stabilization of unstable upper cervical injuries usually should avoid the use of traction in favour of the halovest.♦ Definitive stabilization is based on fracture type and the status of the cranio-cervical ligaments.

This chapter focuses on the fixed points of a strictly semi-linear automorphism of order 2 of a spherical building which satisfies the conditions laid out in Hypothesis 30.1. It begins with the fhe definition of a spherical building satisfying the Moufang condition and a Galois involution of Δ‎, described as an automorphism of Δ‎ of order 2 that is strictly semi-linear. It can be recalled that Δ‎ can have a non-type-preserving semi-linear automorphism only if its Coxeter diagram is simply laced. The chapter assumes that the building Δ‎ being discussed is as in 30.1 and that τ‎ is a Galois involution of Δ‎. It also considers the notation stating that the polar region of a root α‎ of Δ‎ is the unique residue of Δ‎ containing the arctic region of α‎.

This chapter discusses the free 2-ball quotients arising as finite covers of the projective plane branched along line arrangements. It first considers a surface X obtained by blowing up the singular intersection points of a linear arrangement in the complex projective plane, as well as a smooth compact complex surface Y that is a finite covering of X. If Y is of general type with vanishing proportionality deviation, then it is a free 2-ball quotient. The chapter then looks at line arrangements that have equal ramification indices along each of the proper transforms of the original lines, along with cases of blowing down rational curves and removing elliptic curves. It also enumerates all possibilities for the assigned weights of the arrangements, under the assumption that divisors of negative or infinite weight on the blown-up line arrangements do not intersect.

Does the implementation of treatment schemes as an integrated element in the sentencing of offenders violate a retributivist view of punishment? Traditional rehabilitationism has often been held to conflict with retributive justice. However, in this chapter it is argued that: 1) treatment schemes can be designed in a way that is fully consistent with retributive proportionality constraints; 2) treatment schemes cannot plausibly be rejected by retributivists as a type of punishment that should be banned in principle; 3) there may be circumstances under which the retributivist should accept treatment schemes even if criminals are being disproportionately punished.

This commentary focuses on Article 3.2.9 of the UNIDROIT Principles of International Commercial Contracts (PICC) concerning confirmation. Under Art 3.2.9, if the party entitled to avoid the contract expressly or impliedly confirms the contract after the period of time for giving notice of avoidance has begun to run, avoidance of the contract is excluded. Art 3.2.9 serves two purposes. On the one hand, it restricts the right to avoid the contract in a certain type of situation where the avoidance would be contrary to good faith. On the other hand, it emphasizes the fact that the party entitled to avoid the contract under the preceding provisions is not obliged to do so, but may also elect to treat the contract as valid. This commentary discusses the requirements for confirmation, whether express or implied, and the ground for avoidance, time for confirmation, and the effect of confirmation on the right to avoid the contract.

Uric acid (UA) stones are typically red-orange and often appear as sand/ gravel though they may be large. They are totally radiolucent. They account for about 10% of all kidney stones in most countries, and up to 20% in some populations. It is twice as frequent in males, prevalence increases with age, and it is two to three times higher in patients with type 2 diabetes or with features of the metabolic syndrome. Factors that induce the formation of UA stones are a low urine volume, hyperuricosuria, and, more importantly, a permanently low urine pH (< 5). Indeed, below its pKa of 5.35 at 37°C, UA is in non-dissociated form, whose solubility is at best 100 mg/L, whereas urinary UA excretion normally exceeds 600 mg/day and may exceed 1g/day.Because UA solubility increases up to approximately 500 mg/L at urine pH > 6, urine alkalinization, with a target pH of 6.5–7, is the cornerstone of medical treatment. This most often allows dissolution of existing stones and prevention of recurrent stone formation so that urological intervention is infrequently needed. The preferred agent for alkalinization is potassium citrate (30–60 mEq/day in divided doses), because potassium urate is twice more soluble than sodium urate. However, in patients with poor gastric tolerance to potassium citrate or contraindication to potassium supplements, sodium bicarbonate is an acceptable alternative. Limitation of animal proteins, purine-rich foods (including beer), alcoholic drinks and acidified beverages (sodas) are useful measures, together with large fluid intake (> 2–2.5 L/day). Allopurinol may be indicated in cases of symptomatic hyperuricaemia. Regular observance of alkalinisation, with periodic controls of urine pH by the patient, is needed to prevent the rapid formation of UA stones. Patients affected by UANL, especially if overweight, should be evaluated for type 2 diabetes or glucose intolerance and managed accordingly.

This commentary focuses on Article 3.2.2 of the UNIDROIT Principles of International Commercial Contracts (PICC) concerning relevant mistake. Art 3.2.2 outlines the specific requirements that must be met if a mistake is relevant under the PICC. There are three different types of requirement: the mistake must reach a certain degree of seriousness, the other party must not be worthy of protection in its reliance on the contract, and the mistaken party must be worthy of protection. This commentary discusses the purpose of Art 3.2.2, the seriousness of mistake, cases where the other party or the mistaken party is not worthy of protection, burden of proof relating to relevant mistake, and consequences of relevant mistake.

The Thesis focuses on Smectic-A (SmA) liquid crystals' (LCs) functional behaviour in order to understand if this will be the next generation product that could improve the daily life of the society. The optical properties of this liquid crystal are by far the best compared to the products available in the market, i.e., the light transmittance in transparent state is >85 % and in scatter state <2 %. Enabling the LC to be used for a variety of purposes, such as smart windows to scatter light on a sunny day or provide a sense of privacy in an open type office space. An in-depth literature review discusses the existing studies, obtained experimental data and attempts to develop functional products. The main unresolved problems are highlighted, described in detail and solutions are offered. In order to understand the potential of SmA LC in the smart glass/window technology, analysis of existing products was performed, a summary of an active smart glass/windows provided, and a comparative study between them was made. In addition, an in-depth study of long-term functional stability was performed during which the most popular types of defects were listed and analysed. Solutions for defect elimination and recommendations for optimization of switching systems and production processes are provided. A methodology for determining the electrical parameters of an LC has been developed in order to create an electrical simulation model and facilitate the development of electronic switching systems.

Von Willebrand disease (vWD) is the most common bleeding disorder in humans. It is the result of an abnormality in the amount, structure, or function of von Willebrand factor (vWF), a glycoprotein important in maintaining normal hemostasis.. In children with vWD, the most frequent presentation is easy bruising and epistaxis. Other symptoms include hematomas, menorrhagia, and bleeding from minor wounds. Although intraarticular bleeding may occur, especially in certain subtypes, it is much more commonly seen with hemophilia. There are several subtypes of vWD based on the underlying defect in vWF, but, in general, they may be categorized as quantitative (types 1 and 3) or qualitative (all types 2). If vWD is suspected, consultation with a hematologist to establish the correct diagnosis and perioperative approach to hemostasis is essential. Avoidance of medications that interfere with coagulation, anticipation of intraoperative and postoperative bleeding, and an appropriate hemostatic treatment plan should be addressed.

Obesity is the most common nutritional disorder affecting children in the developed world. The marked increase in prevalence is linked to environmental and behavioural changes; children’s energy expenditure has undoubtedly decreased. Obese children often become obese adults; children from lower socioeconomic groups are more likely to be obese. Obesity is a risk factor for ischaemic heart disease, hypertension, stroke, type 2 diabetes, depression, and certain cancers. There is no proven preventive strategy but limiting time in front of computer and TV screens appears important. Obese children are relatively tall; the combination of obesity with short stature suggests underlying disease (e.g. hypothyroidism; Cushing’s syndrome should be considered). Treatment should be considered if body mass index is greater than the 98th centile and the family are willing to make the necessary lifestyle changes. Drug and surgical treatments have a role in a small number of children, but should always be used on a background of a behavioural weight management programme.

This chapter reviews the basic positions of religious Zionism on war in theology and Halakhah. It explores the main halakhic questions religious Zionist rabbis had to resolve for a Jewish state to wage war in the modern period: (1) Which types of war in medieval Halakhah were still applicable? Could a modern Jewish state wage defensive wars? If so, could it also wage more aggressive “discretionary” wars? (2) What legitimate authority could initiate war? Did it require a king, or was a democratically elected government sufficient? (3) Could the state conscript soldiers if Halakhah did not normally require an individual to sacrifice his life for the sake of others? (4) Could one kill civilians, even accidentally? Halakhah does not normally allow one to take innocent life. The chapter then maps out the goal of the study, to examine how five prominent religious Zionist rabbis dealt with these challenges.

Chapter 2, by Chandra Lekha Sriram, offers comparative lessons and challenges in understanding transitional justice from a global perspective, with some examples from and reflections for the MENA region. She identifies four types of challenges in discussing the topic, which have arisen from experiences in other regions but are equally relevant in the region. The first is how the impact of transitional justice can be assessed, if at all. The second is that of who is calling for transitional justice, and what the views of it are, particularly from the grass-roots level. The third is that of the effects of institutional design of specific transitional justice measures. And the final challenge is the appropriate scope of such measures, including whether they should include a range of social and economic concerns.

The incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) is increasing, reflecting an increase in the incidence and prevalence of hypertension and type 2 diabetes. Patients with CKD and ESKD frequently experience episodes of critical illness and require treatment in an intensive care unit (ICU)setting. Management requires specific consideration of their renal disease status together with their acute illness. Mortality in critically-ill patients with ESKD is frequently related to their co-morbid conditions, rather than their ESKD status. Illness severity scoring systems allocate high points for renal variables and tend to overestimate actual mortality. Patients with ESKD and CKD requiring ICU admission have better ICU and in-hospital survival than patients with denovo acute kidney injury requiring renal replacement therapy. Appropriately selected patients benefit from ICU admission and full consideration for ICU care should be given to these patients if required, despite their renal disease status. Cardiovascular disease and sepsis account for the majority of ICU admissions in this population and the aetiology of these conditions differs from that in patients without kidney disease. Optimal critical care management of patients with ESKD and CKD requires that these differences are recognized.

In 1976, Israel conducted a successful, but highly controversial military rescue operation in Entebbe, Uganda, to save its nationals taken hostage on Ugandan territory by members of the ‘Popular Front of Liberation of Palestine’. From an international legal perspective, this case revolves around the existence of a right of a state to take military action to protect its nationals abroad in mortal danger. Following an extensive legal debate in the Security Council on the incident, it appears safe to conclude that a rescue operation such as conducted in Entebbe passes the threshold for a use of force within the meaning of Article 2(4) UN Charter. In light of the ambiguous justification, however, it appears that an Entebbe-type situation falls within a grey area of the prohibition of the use of force. Still, the incident suggests that if states are willing to support the legality of a military rescue operation only the right of self-defence can conceivably justify such a use of force, and only in a case where the local state does not itself deal with the threat in good faith, and under strict conditions of proportionality.

Herpes simplex virus (HSV) types 1 and 2 cause several important syndromes, including congenital and perinatal infections that can cause devastating consequences in newborns (i.e., neonatal HSV). Most neonatal HSV infections are acquired intrapartum in the infected maternal birth canal. Since genital HSV infections are common, neonatal HSV is an important complication in infected women, even if maternal symptoms are absent. As a result of the developmental status of the fetal and newborn immune system, neonatal HSV infection is associated with life-threatening disease. This chapter reviews the clinical presentations of neonatal HSV infection, as well as advances in diagnosis and therapy. Skin vesicles and fever are often absent, which contributes to a delay in initiating effective therapy. Early recognition is key. Despite significant advances in diagnostic testing and antiviral treatment for neonatal HSV, morbidity and mortality remain high and no vaccine is currently available for clinical use.

At STIAS, the ‘Health in Transition’ theme includes a programme to address the epidemic rise in the incidence of non-communicable diseases (NCDs) such as Type 2 diabetes, hypertension, obesity, coronary heart disease and stroke in Africa. The aim is to advance awareness, research capacity and knowledge translation of science related to the Developmental Origins of Health and Disease (DOHaD) as a means of preventing NCDs in future generations. Application of DOHaD science is a promising avenue for prevention, as this field is identifying how health and nutrition from conception through the first 1 000 days of life can dramatically impact a developing individual’s future life course, and specifically predicate whether or not they are programmed in infancy to develop NCDs in later life. Prevention of NCDs is an essential strategy as, if unchecked, the burden of caring for a growing and ageing population with these diseases threatens to consume entire health budgets, as well as negatively impact the quality of life of millions. Africa in particular needs specific, focussed endeavors to realize the maximal preventive potential of DOHaD science, and a means of generating governmental and public awareness about the links between health in infancy and disease in adult life. This volume summarizes the expertise and experience of a leading group of international scientists led by Abdallah Daar brought together at STIAS as part of the ‘Health in Transition’ programme.

Elusiveness signals are given by prey during the close approach of a predator, acting to inform the predator that the prey would be difficult to catch and subdue, and, therefore, that an attempt to catch the prey is likely to be unsuccessful. These signals will be restricted to mobile prey that can mount an active response to impending attack and they will not normally be displayed continuously, but instead be triggered by the perception by the prey that they are under imminent risk of attack. There are two different types of such elusiveness signals: 1) pursuit deterrent signals, communicating fleetness or strength to coursing predators, and 2) perception advertisement, communicating detection of a stalking or ambushing predator. Elusiveness signals can only be effective if mounting attacks is expensive to predators in some way. There is also an element of generalization required for elusiveness signals to be effective but, by signalling fleetness, strength, or awareness of the predator, the prey also seek to differentiate themselves from other potential prey. We first document current empirical evidence for elusiveness signalling, before discussing evolutionary considerations—starting with theory on how such signalling might evolve and be maintained—ecological aspects, and co-evolutionary considerations.

Employer-provided benefits are independent elements in the compensation packages that make up firms’ payment strategies. Such benefits are aimed at attracting and retaining preferred employees and improving incentives. In Myanmar, there are two employee benefit systems: (1) an unregulated traditional system in which firms offer their employees in-kind benefits such as meals and accommodation; and (2) a modern mandatory system in which firms are required by law to offer payment schemes such as payment-while-absent and compensation for accidents. Using a survey of matched employers and employees in the manufacturing sector in Myanmar, we identify firms and workers that supply and demand the two types of employee benefits. We show that traditional benefits are widely supplied and demanded, while modern benefits are supplied by fewer firms and provided to fewer workers. We analyse the relative importance of a range of observable firm and worker attributes that may be associated with the supply and demand for the benefits. We find that firms that provide accommodation appear to attract young, unmarried, uneducated workers who are often migrants, and who, on average, receive lower wages compared to similar workers who do not receive equal in-kind payments. Large firms are more likely to offer the modern benefits and highly educated workers are more likely to demand them. Moreover, workers who receive modern benefits tend to stay longer with the firm and the benefit appears not to have an adverse impact on their wage level. Our findings indicate that both types of benefits contribute to sorting in the labour market. Therefore, both must be considered when labour laws are amended. Moreover, if increased minimum wages are accompanied by reduced provision of traditional in-kind benefits to low-wage workers, then there is a real risk that inequality in consumption will increase even though wage inequality decreases.

Alterations in left ventricular (LV) mass and geometry and LV dysfunction increase in prevalence from stage 2 to stage 5 in CKD. Nuclear magnetic resonance is the most accurate and precise technique for measuring LV mass and function in patients with heart disease. Quantitative echocardiography is still the most frequently used means of evaluating abnormalities in LV mass and function in CKD. Anatomically, myocardial hypertrophy can be classified as concentric or eccentric. In concentric hypertrophy, the muscular component of the LV (LV wall) predominates over the cavity component (LV volume). Due to the higher thickness and myocardial fibrosis in patients with concentric LVH, ventricular compliance is reduced and the end-diastolic volume is small and insufficient to maintain cardiac output under varying physiological demands (diastolic dysfunction). In those with eccentric hypertrophy, tensile stress elongates myocardiocytes and increases LV end-diastolic volume. The LV walls are relatively thinner and with reduced ability to contract (systolic dysfunction). LVH prevalence increases stepwisely as renal function deteriorates and 70–80% of patients with kidney failure present with established LVH which is of the concentric type in the majority. Volume overload and severe anaemia are, on the other hand, the major drivers of eccentric LVH. Even though LVH may regress after renal transplantation, the prevalence of LVH after transplantation remains close to that found in dialysis patients and a functioning renal graft should not be seen as a guarantee of LVH regression. The vast majority of studies on cardiomyopathy in CKD are observational in nature and the number of controlled clinical trials in these patients is very small. Beta-blockers (carvedilol) and angiotensin receptors blockers improve LV performance and reduce mortality in kidney failure patients with LV dysfunction. Although current guidelines recommend implantable cardioverter-defibrillators in patients with ejection fraction less than 30%, mild to moderate symptoms of heart failure, and a life expectancy of more than 1 year, these devices are rarely offered to eligible CKD patients. Conversion to nocturnal dialysis and to frequent dialysis schedules produces a marked improvement in LVH in patients on dialysis. More frequent and/or longer dialysis are recommended in dialysis patients with asymptomatic or symptomatic LV disorders if the organizational and financial resources are available.

Economy and mankind are inextricably interlinked. Just as the economy or the production of material wealth is unimaginable without a man, so human existence and development are impossible without the wealth created in the economy. Shortly, both the goal and the means of achieving and realization of the economy are still the human resources. People have long ago noticed that it was the economy that created livelihoods, and the delays in their production led to the catastrophic events such as hunger, poverty, civil wars, social upheavals, revolutions, moral degeneration, and more. Therefore, the special interest of people in understanding the regulatory framework of the functioning of the economy has existed and exists in all historical epochs [A. Sisvadze. Economic theory. Part One. 2006y. p. 22]. The system of economic disciplines studies economy or economic activities of a society. All of them are based on science, which is currently called economic theory in the post-socialist space (the science of economics, the principles of economics or modern economics), and in most countries of the world - predominantly in the Greek-Latin manner - economics. The title of the present book is also Modern Economics. Economics (economic theory) is the science that studies the efficient use of limited resources to produce and distribute goods and services in order to satisfy as much as possible the unlimited needs and demands of the society. More simply, economics is the science of choice and how society manages its limited resources. Moreover, it should be emphasized that economics (economic theory) studies only the distribution, exchange and consumption of the economic wealth (food, beverages, clothing, housing, machine tools, computers, services, etc.), the production of which is possible and limited. And the wealth that exists indefinitely: no economic relations are formed in the production and distribution of solar energy, air, and the like. This current book is the second complete updated edition of the challenges of the modern global economy in the context of the coronary crisis, taking into account some of the priority directions of the country's development. Its purpose is to help students and interested readers gain a thorough knowledge of economics and show them how this knowledge can be applied pragmatically (professionally) in professional activities or in everyday life. To achieve this goal, this textbook, which consists of two parts and tests, discusses in simple and clear language issues such as: the essence of economics as a science, reasons for origin, purpose, tasks, usefulness and functions; Basic principles, problems and peculiarities of economics in different economic systems; Needs and demand, the essence of economic resources, types and limitations; Interaction, mobility, interchangeability and efficient use of economic resources. The essence and types of wealth; The essence, types and models of the economic system; The interaction of households and firms in the market of resources and products; Market mechanism and its elements - demand, supply and price; Demand and supply elasticity; Production costs and the ways to reduce them; Forms of the market - perfect and incomplete competition markets and their peculiarities; Markets for Production Factors and factor incomes; The essence of macroeconomics, causes and importance of origin; The essence and calculation of key macroeconomic indicators (gross national product, gross domestic product, net national product, national income, etc.); Macroeconomic stability and instability, unemployment, inflation and anti-inflationary policies; State regulation of the economy and economic policy; Monetary and fiscal policy; Income and standard of living; Economic Growth; The Corona Pandemic as a Defect and Effect of Globalization; National Economic Problems and New Opportunities for Development in the conditions of the Coronary Crisis; The Socio-economic problems of moral obsolescence in digital technologies; Education and creativity are the main solution way to overcome the economic crisis caused by the coronavirus; Positive and negative effects of tourism in Georgia; Formation of the middle class as a contributing factor to the development of tourism in Georgia; Corporate culture in Georgian travel companies, etc. The axiomatic truth is that economics is the union of people in constant interaction. Given that the behavior of the economy reflects the behavior of the people who make up the economy, after clarifying the essence of the economy, we move on to the analysis of the four principles of individual decision-making. Furtermore, the book describes how people make independent decisions. The key to making an individual decision is that people have to choose from alternative options, that the value of any action is measured by the value of what must be given or what must be given up to get something, that the rational, smart people make decisions based on the comparison of the marginal costs and marginal returns (benefits), and that people behave accordingly to stimuli. Afterwards, the need for human interaction is then analyzed and substantiated. If a person is isolated, he will have to take care of his own food, clothes, shoes, his own house and so on. In the case of such a closed economy and universalization of labor, firstly, its productivity will be low and, secondly, it will be able to consume only what it produces. It is clear that human productivity will be higher and more profitable as a result of labor specialization and the opportunity to trade with others. Indeed, trade allows each person to specialize, to engage in the activities that are most successful, be it agriculture, sewing or construction, and to buy more diverse goods and services from others at a relatively lower price. The key to such human interactions is that trade is mutually beneficial; That markets are usually the good means of coordination between people and that the government can improve the results of market functioning if the market reveals weakness or the results of market functioning are not fair. Moroever, it also shows how the economy works as a whole. In particular, it is argued that productivity is a key determinant of living standards, that an increase in the money supply is a major source of inflation, and that one of the main impediments to avoiding inflation is the existence of an alternative between inflation and unemployment in the short term, that the inflation decrease causes the temporary decline in unemployement and vice versa. The Understanding creatively of all above mentioned issues, we think, will help the reader to develop market economy-appropriate thinking and rational economic-commercial-financial behaviors, to be more competitive in the domestic and international labor markets, and thus to ensure both their own prosperity and the functioning of the country's economy. How he/she copes with the tasks, it is up to the individual reader to decide. At the same time, we will receive all the smart useful advices with a sense of gratitude and will take it into account in the further work. We also would like to thank the editor and reviewers of the books. Finally, there are many things changing, so it is very important to realize that the XXI century has come: 1. The century of the new economy; 2. Age of Knowledge; 3. Age of Information and economic activities are changing in term of innovations. 1. Why is the 21st century the century of the new economy? Because for this period the economic resources, especially non-productive, non-recoverable ones (oil, natural gas, coal, etc.) are becoming increasingly limited. According to the World Energy Council, there are currently 43 years of gas and oil reserves left in the world (see “New Commersant 2007 # 2, p. 16). Under such conditions, sustainable growth of real gross domestic product (GDP) and maximum satisfaction of uncertain needs should be achieved not through the use of more land, labor and capital (extensification), but through more efficient use of available resources (intensification) or innovative economy. And economics, as it was said, is the science of finding the ways about the more effective usage of the limited resources. At the same time, with the sustainable growth and development of the economy, the present needs must be met in a way that does not deprive future generations of the opportunity to meet their needs; 2. Why is the 21st century the age of knowledge? Because in a modern economy, it is not land (natural resources), labor and capital that is crucial, but knowledge. Modern production, its factors and products are not time-consuming and capital-intensive, but science-intensive, knowledge-intensive. The good example of this is a Japanese enterprise (firm) where the production process is going on but people are almost invisible, also, the result of such production (Japanese product) is a miniature or a sample of how to get the maximum result at the lowest cost; 3. Why is the 21st century the age of information? Because the efficient functioning of the modern economy, the effective organization of the material and personal factors of production largely depend on the right governance decision. The right governance decision requires prompt and accurate information. Gone are the days when the main means of transport was a sailing ship, the main form of data processing was pencil and paper, and the main means of transmitting information was sending letters through a postman on horseback. By the modern transport infrastructure (highways, railways, ships, regular domestic and international flights, oil and gas pipelines, etc.), the movement of goods, services and labor resoucres has been significantly accelerated, while through the modern means of communication (mobile phone, internet, other) the information is spreading rapidly globally, which seems to have "shrunk" the world and made it a single large country. The Authors of the book: Ushangi Samadashvili, Doctor of Economic Sciences, Associate Professor of Ivane Javakhishvili Tbilisi State University - Introduction, Chapters - 1, 2, 3, 4, 5, 6, 9, 10, 11,12, 15,16, 17.1,18 , Tests, Revaz Shengelia, Doctor of Economics, Professor of Georgian Technical University, Chapters_7, 8, 13. 14, 17.2, 17.4; Zhuzhuna Tsiklauri - Doctor of Economics, Professor of Georgian Technical University - Chapters 13.6, 13.7,17.2, 17.3, 18. We also thank the editor and reviewers of the book.

An analysis of the existing literature on the issue of damage to regeneration caused by timber harvesting, revealed that a great majority of results reported in those publications was obtained through laborious and time-consuming field research conducted in two stages. Field research methods for gathering data, employed by various authors, differed in terms of the manner of establishing trial plots, the accuracy of counting and evaluating the number of saplings growing on the investigated sites, classification systems used for distinguishing particular groups of regeneration based on quantitative (diameter at breast height, tree height) and qualitative features (biosocial position within the certain layer and the entire stand), classification systems used for identifying types of damage caused by cutting and felling, as well as transporting operations, and finally the duration of observation intervals and time spent on gathering data on the response of damaged saplings from both, the individual and collective perspectives. Obviously, the most reliable manner of gathering such data would be to count all damaged elements of the environment being a subject of interest of particular investigators at the certain point of time. However, due to time and work consumption of this approach, which is besides very costly, any research should be designed in such a manner as to reduce the above-mentioned factors. This paper aimed to (1) analyse the probability of occurrence of damage to regeneration depending on the form of timber assortments dragged from the felling site to the skidding routes, and timber harvesting technology employed in logging works, and (2) identify a method ensuring that gathered data is sufficient for performing reliable evaluation of share of damage to regeneration at acceptable accuracy level, without necessity to establish trial plots before commencing harvesting works. The scope of these studies enclosed a comparison between two motor-manual methods of timber harvesting in thinned stands, with dragging of timber in the first stage of skidding from the stand to landings. According to one of these methods, a classical one, operations of felling and delimbing of trees were carried out by sawmen at the felling site. Timber obtained using different methods was skidded by carters and horses, and operators of a light-duty cable winch, driven by the chainsaw’s engine, as well as operators of cable winches combined with farm tractors. In the latter, alternative method, sawmen performed only cutting and felling of trees. Delimbing and cross-cutting of trunks, dragged from the felling sites, was carried out by operators of processors combined with farm tractors, worked on skidding routes. The research was conducted in the years 2002–2010 in stands within the age classes II–IV mostly, located in the territories of Regional Directorates of State Forests in Krakow and Katowice, and in the Forest Experimental Unit in Krynica-Zdrój. In the course of a preliminary stage of investigations 102 trial plots were established in stands within early and late tinning treatments. As a result of the field research carried out in two stages, more than 3.25 thsd. circular sites were established and marked, on the surface of which over 25 thsd. saplings constituting the regeneration layer were inventoried. Based on the results of investigations and analyses it was revealed that regardless of the category of thinning treatment, the highest probability of occurrence of destroying P(ZN) to regeneration (0.24–0.44) should be expected when the first stage of timber skidding is performed using cable winches. Slightly lower values of probability (0.17–0.33) should be expected in stands where timber is skidded by horses, while in respect to processor-based skidding technology the probability of destroying occurrence oscillates between 0.12 and 0.27, depending on the particular layer of regeneration. P(ZN) values, very close to those of skidding technology engaging processors, were recorded for skidding performed using the light-duty cable winch driven by the chainsaw’s engine (0.16–0.27). The highest probability of damage P(USZK) to regeneration (0.16–0.31) can be expected when processors are used in the first stage of timber skidding. Slightly lower values of probability (0.14–0.23) were obtained when skidding was performed with the use of cable winches, whereas engaging horses for hauling of trunks results in probability of damage occnrrence oscillating between 0.05–0.20, depending on the particular layer of regeneration. With regard to the probability of occurrence of both, destroying and damage P(ZNUSZK) to regeneration (0.33–0.54), the highest values can be expected when cable winches are engaged in the first stage of skidding. Little lower (0.30–0.43) was the probability of their occurrence if processor-based technology of skidding was employed, while in respect to horse skidding these values oscillated between 0.27–0.41, depending on the layer of regeneration. The lowest values of probability of occurrence of damage P(USZK), and destroying and damage treated collectively P(ZNUSZK), within all layers of regeneration, were recorded in stands where thinning treatments were performed using the light-duty cable winch driven by the chainsaw’s engine. The models evaluated and respective equations, developed based on those models, for evaluating the number of destroyed saplings ZNha (tab. 40, 42, 44, 46, 48) could be used for determining the share of damage expressed as a percentage, upon conducting only one field research at the investigated felling sites, once the timber harvesting and skidding would have been completed. As revealed by the results of analyses, evaluation of statistically significant regression models was possible for all layers of regeneration (tab. 39, 41, 43, 45, 47). Nevertheless, the smallest part of these models that could be considered positively verified, were those for the natural young regeneration, although almost a half of them revealed to be significant. Within the medium-sized regeneration over three-fourths of all models could be considered positively verified, four of which explained more than 50% of variability. Within the high-sized regeneration almost two-thirds of evaluated regression models were statistically significant, five of which were verified positively, moreover, one of them explained more than 50% of variability. The most promising results were those obtained for the advance growth. Nearly 90% of the evaluated models revealed to be statistically significant, ten of which could be considered positively verified. Furthermore, four statistically significant models explained over 50% of general variability. With regard to the entire regeneration more than 80% of evaluated models were statistically significant. However, due to insignificant coefficients of regression, eight of them could be considered positively verified. At this point it should be stressed that in respect to logging technology employing the light-duty cable winch FKS it was impossible to evaluate statistically significant models of regression. Whereas, in the case of processor-based logging technology, firstly regarding the advance growth, and then the entire regeneration, all of the evaluated statistically significant models could be considered positively verified, in terms of both, all of the stands, and particular categories of thinning treatments individually. This latter case also revealed the highest degree of matching of evaluated models (R2 popr 0.73–0.76 for advance growth and 0.78–0.94 for the entire regeneration). A significant impact of the kind of form of hauled timber on the probability of damage occurrence P(USZK), mainly in early thinning treatments, could have been reflected in the results obtained for all stands (early and late thinning treated collectively). Moreover, due to an insignificant impact of the form of hauled timber and logging technology employed, on the probability of occurrence of damage in late thinned stands, and a significant impact of the above-mentioned variables on early thinned stands, it should be assumed that for performing an evaluation of destroying and damage caused by timber harvesting the both thinning treatment categories should be analysed separately. Furthermore, when evaluating the probability of occurrence of destroying and damage caused by timber harvesting, the layers of natural young regeneration and advance growth should be analysed separately. As proved by the results presented in this paper, varying values of probability computed for each of the layers of regeneration seem to indicate that when investigating damage to regeneration caused by timber harvesting, it would be reasonable and recommended to perform a separate analysis of damage to the highest saplings as well, namely individuals with diameter at breast height close to 7 cm. In respect to studies on damage to regeneration caused by logging technologies mentioned above, the evaluation of number of destroyed saplings within the advance growth can be carried out using the proportions of damaged and undamaged saplings per 1 ha of the stand. The numbers evaluated in this manner can be used to calculate the damage share expressed in relative values (percentage of damaged saplings compared with the entire number of saplings before commencing the logging works). However, one should keep in mind that this is true only if the field research have been carried out based on the methodology described in this paper.

The monograph reflects the problems of Russian psycholinguistics from the moment of its inception in Russia to the present day and presents its main directions that are currently developing. In addition, theoretical developments and practical results obtained in the framework of different directions and research centers are described in a concise form. The task of the book is to reflect, as far as it is possible in one edition, firstly, the history of the formation of Russian psycholinguistics; secondly, its methodology and developed methods; thirdly, the results obtained in different research centers and directions in different regions of Russia; fourthly, to outline the main directions of the further development of Russian psycholinguistics. There is no doubt that in the theoretical, methodological and applied aspects, the main problems and the results of their development by Russian psycholinguistics have no analogues in world linguistics and psycholinguistics, or are represented by completely original concepts and methods. We have tried to show this uniqueness of the problematics and the methodological equipment of Russian psycholinguistics in this book. The main role in the formation of Russian psycholinguistics was played by the Moscow psycholinguistic school of A.A. Leontyev. It still defines the main directions of Russian psycholinguistics. Russian psycholinguistics (the theory of speech activity - TSA) is based on the achievements of Russian psychology: a cultural-historical approach to the analysis of mental phenomena L.S. Vygotsky and the system-activity approach of A.N. Leontyev. Moscow is the most "psycholinguistic region" of Russia - INL RAS, Moscow State University, Moscow State Linguistic University, RUDN, Moscow State Pedagogical University, Moscow State Pedagogical University, Sechenov University, Moscow State University and other Moscow universities. Saint Petersburg psycholinguists have significant achievements, especially in the study of neurolinguistic problems, ontolinguistics. The most important feature of Russian psycholinguistics is the widespread development of psycholinguistics in the regions, the emergence of recognized psycholinguistic research centers - St. Petersburg, Tver, Saratov, Perm, Ufa, Omsk, Novosibirsk, Voronezh, Yekaterinburg, Kursk, Chelyabinsk; psycholinguistics is represented in Cherepovets, Ivanovo, Volgograd, Vyatka, Kaluga, Krasnoyarsk, Irkutsk, Vladivostok, Abakan, Maikop, Barnaul, Ulan-Ude, Yakutsk, Syktyvkar, Armavir and other cities; in Belarus - Minsk, in Ukraine - Lvov, Chernivtsi, Kharkov, in the DPR - Donetsk, in Kazakhstan - Alma-Ata, Chimkent. Our researchers work in Bulgaria, Hungary, Vietnam, China, France, Switzerland. There are Russian psycholinguists in Canada, USA, Israel, Austria and a number of other countries. All scientists from these regions and countries have contributed to the development of Russian psycholinguistics, to the development of psycholinguistic theory and methods of psycholinguistic research. Their participation has not been forgotten. We tried to present the main Russian psycholinguists in the Appendix - in the sections "Scientometrics", "Monographs and Manuals" and "Dissertations", even if there is no information about them in the Electronic Library and RSCI. The principles of including scientists in the scientometric list are presented in the Appendix. Our analysis of the content of the resulting monograph on psycholinguistic research in Russia allows us to draw preliminary conclusions about some of the distinctive features of Russian psycholinguistics: 1. cultural-historical approach to the analysis of mental phenomena of L.S.Vygotsky and the system-activity approach of A.N. Leontiev as methodological basis of Russian psycholinguistics; 2. theoretical nature of psycholinguistic research as a characteristic feature of Russian psycholinguistics. Our psycholinguistics has always built a general theory of the generation and perception of speech, mental vocabulary, linked specific research with the problems of ontogenesis, the relationship between language and thinking; 3. psycholinguistic studies of speech communication as an important subject of psycholinguistics; 4. attention to the psycholinguistic analysis of the text and the development of methods for such analysis; 5. active research into the ontogenesis of linguistic ability; 6. investigation of linguistic consciousness as one of the important subjects of psycholinguistics; 7. understanding the need to create associative dictionaries of different types as the most important practical task of psycholinguistics; 8. widespread use of psycholinguistic methods for applied purposes, active development of applied psycholinguistics. The review of the main directions of development of Russian psycholinguistics, carried out in this monograph, clearly shows that the direction associated with the study of linguistic consciousness is currently being most intensively developed in modern Russian psycholinguistics. As the practice of many years of psycholinguistic research in our country shows, the subject of study of psycholinguists is precisely linguistic consciousness - this is a part of human consciousness that is responsible for generating, understanding speech and keeping language in consciousness. Associative experiments are the core of most psycholinguistic techniques and are important both theoretically and practically. The following main areas of practical application of the results of associative experiments can be outlined. 1. Education. Associative experiments are the basis for constructing Mind Maps, one of the most promising tools for systematizing knowledge, assessing the quality, volume and nature of declarative knowledge (and using special techniques and skills). Methods based on smart maps are already widely used in teaching foreign languages, fast and deep immersion in various subject areas. 2. Information search, search optimization. The results of associative experiments can significantly improve the quality of information retrieval, its efficiency, as well as adaptability for a specific person (social group). When promoting sites (promoting them in search results), an associative experiment allows you to increase and improve the quality of the audience reached. 3. Translation studies, translation automation. An associative experiment can significantly improve the quality of translation, take into account intercultural and other social characteristics of native speakers. 4. Computational linguistics and automatic word processing. The results of associative experiments make it possible to reveal the features of a person's linguistic consciousness and contribute to the development of automatic text processing systems in a wide range of applications of natural language interfaces of computer programs and robotic solutions. 5. Advertising. The use of data on associations for specific words, slogans and texts allows you to predict and improve advertising texts. 6. Social relationships. The analysis of texts using the data of associative experiments makes it possible to assess the tonality of messages (negative / positive moods, aggression and other characteristics) based on user comments on the Internet and social networks, in the press in various projections (by individuals, events, organizations, etc.) from various social angles, to diagnose the formation of extremist ideas. 7. Content control and protection of personal data. Associative experiments improve the quality of content detection and filtering by identifying associative fields in areas subject to age restrictions, personal information, tobacco and alcohol advertising, incitement to ethnic hatred, etc. 8. Gender and individual differences. The data of associative experiments can be used to compare the reactions (and, in general, other features of thinking) between men and women, different social and age groups, representatives of different regions. The directions for the further development of Russian psycholinguistics from the standpoint of the current state of psycholinguistic science in the country are seen by us, first of all:  in the development of research in various areas of linguistic consciousness, which will contribute to the development of an important concept of speech as a verbal model of non-linguistic consciousness, in which knowledge revealed by social practice and assigned by each member of society during its inculturation is consolidated for society and on its behalf;  in the expansion of the problematics, which is formed under the influence of the growing intercultural communication in the world community, which inevitably involves the speech behavior of natural and artificial bilinguals in the new object area of psycholinguistics;  in using the capabilities of national linguistic corpora in the interests of researchers studying the functioning of non-linguistic and linguistic consciousness in speech processes;  in expanding research on the semantic perception of multimodal texts, the scope of which has greatly expanded in connection with the spread of the Internet as a means of communication in the life of modern society;  in the inclusion of the problems of professional communication and professional activity in the object area of psycholinguistics in connection with the introduction of information technologies into public practice, entailing the emergence of new professions and new features of the professional ethos;  in the further development of the theory of the mental lexicon (identifying the role of different types of knowledge in its formation and functioning, the role of the word as a unit of the mental lexicon in the formation of the image of the world, as well as the role of the natural / internal metalanguage and its specificity in speech activity);  in the broad development of associative lexicography, which will meet the most diverse needs of society and cognitive sciences. The development of associative lexicography may lead to the emergence of such disciplines as associative typology, associative variantology, associative axiology;  in expanding the spheres of applied use of psycholinguistics in social sciences, sociology, semasiology, lexicography, in the study of the brain, linguodidactics, medicine, etc. This book is a kind of summarizing result of the development of Russian psycholinguistics today. Each section provides a bibliography of studies on the relevant issue. The Appendix contains the scientometrics of leading Russian psycholinguists, basic monographs, psycholinguistic textbooks and dissertations defended in psycholinguistics. The content of the publications presented here is convincing evidence of the relevance of psycholinguistic topics and the effectiveness of the development of psycholinguistic problems in Russia.