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1

Bietz, Breanna L. "Always the Icarus". ScholarWorks@UNO, 2017. http://scholarworks.uno.edu/td/2298.

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Always the Icarus is an experimental play in two acts depicting the road-trip journey of meth-fueled, anti-heroine, Cartla, and her best friend, J.A. –a Juggalo with a heart of gold. Cartla desperately needs to leave the Midwestern nothingness of Interior, South Dakota after having a premonition about the fate of America’s favorite T.V. food guy, Guy Fieri. The lines between memory and vivid hallucination become desperately scrambled for the young, twisted duo as they venture from stop to stop along the lucid route to Anaheim, California. With each passing stop, Cartla is confronted by her inescapable geo-historical and geo-familial coordinates as well as a whole slew of characters who refuse to accept the idea that the coveted “American dream” may be grossly out of reach for the forgotten “trash” of the nation. But who will be the saviors of the broken and the ambassadors of the underdogs? Do the maneuvers of the father undoubtedly scar the psyche of the oblivious, devoted child? Do mythologies leave room for less-tragic margins of error?Through a theatrical narrative form stressing cyclical language and interactions, audiences are urged to question whether the mythic Icarus will always fall from the soaring, sky-heights of heaven into the cold waters below.

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2

León, Mariano. "Behua Icara: Sonidos para sanar". Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/657559.

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3

Mendes-Geffroy, Véronique. "Voyage en Icarie, aux noms du père : 1772-2005". Poitiers, 2011. http://www.theses.fr/2011POIT5030.

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Le 3 février 1848, 69 icariens partent du Havre sur le bâteau "Rome" pour le Nouveau Monde. Un roman "voyage en Icarie", écrit sous forme de conte , et le combat politique de son auteur etienne Cabet ont convaincu quelques aventuriers de tenter une expérience : croire qu'une société utopique , soumise aux principes icariens du roman, était réalisable en Amérique. .
On the thirdd February 1848, 69 icarians set sail from "Le Havre" abord "The Rome" on a voyage to the New World. A novel, "Voyage to Icaria", written by Etienne Cabet in the style of a traditionnal tale, and the political struggle of its author, had persuaded these adventurers to found an Icarian utopian society in America. .

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4

Desachy, Jacky. "Interpretation automatique d'images satellite : le systeme icare". Toulouse 3, 1991. http://www.theses.fr/1991TOU30084.

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Le but du systeme icare est d'ameliorer les classifications supervisees usuelles utilisees pour produire des cartes a partir des images satellite. L'auteur propose pour cela d'utiliser des informations exogenes (information geocodee disponible) et les connaissances de l'expert sur les caracteristiques de la region etudiee dans un systeme expert. Le processus deductif va alors raisonner sur l'image en utilisant la connaissance des caracteristiques de contexte des classes cherchees et les donnees exogenes (les connaissances de l'expert etant memorisees dans une base de connaissances sous forme de regles de production avec des facteurs de certitude). Le systeme realise la suite d'operations suivantes: -une classification supervisee est appliquee (incluant une mesure de texture basee sur les matrices de cooccurrences) qui donne pour chaque pixel (x,y) son degre d'appartenance cfi(x,y) a chaque classe i recherchee. -a l'aide des donnees exogenes, le contexte de chaque pixel est calcule a l'aide de la logique floue (altitude, ensoleillement, orientation, distance a une route, zone irrigable,. . . ) et en activant toutes les regles de production, les degres d'appartenance cfi(x,y) sont mis a jour (augmentes si le contexte du pixel est favorable a la presence de la classe i). Le systeme icare peut d'autre part etre utilise en resolveur de problemes si les donnees concernees se trouvent dans une base de donnees geographiques et si la solution peut prendre la forme d'une carte de priorites

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5

Nichols, Laura E. "The Icarus Machine : a kinetic sculpture that demonstrates gyroscopic precision". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32977.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
Includes bibliographical references.
Inspired by the desire to unite aspects of art and engineering into a comprehensive whole, I have designed and manufactured a kinetic sculpture that demonstrates gyroscopic precession. The aim of this project is to explore the interplay between two seemingly separate fields, art and engineering, and the effect of their union on perception and learning.
by Laura E. Nichols.
S.B.

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6

Dare-Edwards, Helena Louise. "Interrogating tweendom online : 'fangirl as pathology', gender/age, and iCarly fandom". Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/59220/.

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Since the early 1990s, fan studies has sought to counter perceptions of the ‘pathology of fandom’ and the devaluation of fans as feminine and infantile. In recent years, some scholars have claimed that fans are newly normalised in popular culture, and it is no longer necessary to contest problematic or pathologising stereotypes of fans. However, the near-exclusive stereotyped representation of ‘hysterical’ crowds of adolescent female fans, and the routine dismissal of ‘fangirls’ in mainstream media and fandom itself, would indicate that not all fans have escaped pathologisation. It is also the case that not all fans have enjoyed equal levels of academic attention. By virtue of their age and gender, girl fans arguably carry the greatest burden of negative stereotyping. Yet they have been notably marginalised in fan studies scholarship and their stereotyped construction has remained largely unchallenged. This thesis seeks to address this imbalance as it offers a timely examination of the cultural construction, circulation and pleasures of fangirl fandom, seeking to challenge and expose the tenacity of what I refer to as, ‘fangirl as pathology’. Using iCarly (2007-2012) fans across three online fan spaces (LiveJournal, Blogspot, and Tumblr) as a case study, it presents an empirical, observational study that aims to further understand the implications of the cultural construction and negative stereotypes of girl fans, and the extent to which they come to shape the landscape of tween TV fandom, or ‘tweendom’. Combining fan studies and girls’ studies, and analysing girls’ fan culture from an intersectional, gender/age perspective, this thesis examines the ways in which fangirl identities are performed and the ‘fangirl’ label is negotiated, and how fans identify with iCarly in relation to their own gendered/generational subjectivities. Strategies of defence and legitimisation are considered within the contexts of hierarchical distinctions in inter-/intra-fandom, how fans are textually represented within the show, and online interactions with the series’ creator-producer. This thesis argues that fandom performs important functions for these young women. As active producers, consumers, and negotiators of media, girl fans’ reproduction of negative and pathologising discourses of fangirls demand reconsideration outside resistance/conformist binaries, and specifically in the context of their stigmatisation and structural age/gender inequalities.

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7

Miller, Lianne Bernadette. "Icarus Paradox : the interplay between entrepreneurial cognition and internal stakeholder perception". Thesis, Anglia Ruskin University, 2014. http://arro.anglia.ac.uk/346869/.

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This thesis focuses on how entrepreneurial cognition interacts with internal stakeholder perception in established entrepreneurial organizations. In addition, the influence of interdependent factors of cognitive biases, temporality, growth and performance on the interaction has been examined. The study is exploratory, phenomenological and framed within an interpretive research paradigm. Primary data was gathered using a qualitative multiple case study methodology. Semi-structured interviews were conducted every three months over an eighteen-month period with entrepreneurs and internal stakeholders of nine organizations in Phase I and three organizations in Phase II. This research is original because it focuses exclusively on the interaction between concepts of entrepreneurial cognition and biases, temporality, internal stakeholder perception, organizational factors, growth and performance for established entrepreneurial organizations. The empirical evidence highlights that cognitive diversity and differences in perception and expectations have an impact on entrepreneurial and internal stakeholder interrelationships in established entrepreneurial organizations. Furthermore, entrepreneurial decision-making leads to the Icarus Paradox of confidence-success-attribution cycle that either moderates or mediates organizational growth and performance. The consequence of longer communication chains is limited information flow that results in cognitive dissonance. The research contributes to closing the gap in literature on the interdependent nature of entrepreneurial cognition and internal stakeholder perception on organizational growth and performance. The contribution to practice therefore is that in established entrepreneurial organizations the entrepreneurs and internal stakeholders can focus on performance by understanding the cause and effect influence of their interactions. This sets the foundation for further research on the interaction between entrepreneurial cognition and other organizational concepts.

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8

Allingham, Michael John Burridge Keith. "Novel roles for ICAM1 in leukocyte transendothelial migration". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1208.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.
Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department Cell and Developmental Biology." Discipline: Cell and Developmental Biology; Department/School: Medicine.

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9

Soland, Peter B. y Peter B. Soland. "Mexican Icarus: Modernity, National Identity, and Aviation Development in Mexico, 1928-1958". Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621874.

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In the decades following the Revolution, government officials and industrialists attempted to strike a balance between preserving a unique national identity and asserting Mexico's place in global affairs as a competitive, modern nation. Veneration of the aviators' bravery and technological mastery cut across political and cultural boundaries, setting standards for the model citizen of a modern world. The symbolic figure of the pilot proved an adept vessel for disseminating the values championed by the country's ruling party. Aviators validated the technological determinism that underpinned the government's development philosophy to domestic audiences, while projecting an image of strength abroad. This study explores the spectacle of aviation in cultural events including film, airshows, goodwill flights, and state-sponsored funerals, connecting the history of aviation to often-conflicting discourses of Revolutionary nationalism and modern cosmopolitanism that were espoused by both national and regional elites.

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10

De, Keyser Rien. "Spatial structuring in trait variation in Polyommatus icarus in a functional context". Thesis, Oxford Brookes University, 2012. https://radar.brookes.ac.uk/radar/items/ccd80171-b454-4ce0-a43a-b4fe5744037e/1/.

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The Common blue butterfly, Polyommatus icarus (Rott,) , is widespread throughout its Palaearctic distribution and persists in areas with differing climatic conditions. It is known to be a highly variable butterfly with marked within and between population variation in morphology, thermal biology, and voltinism. These traits together with allozymes and a neutral DNA marker (AFLP) variation are studied here to understand how geographic trait variation is related to environmental variation. The approach adopted here is to study this along a latitudinal cline of temperature and photoperiod, using four populations from south to north within mainland Britain. AFLP differences, but not allozyme variation, indicate genetic structuring, with an isolation by distance effect. Enzyme diversity of P. icarus butterflies in the British Isles is lower than on mainland Europe, indicative of a past bottleneck. This, combined with selection on, or drift in, the allozymes could cause for a lack of population structure in this marker. Despite high levels of gene flow between populations, local adaptation is possible, as differentiation in certain allozyme loci was found (PGM and PGI). Populations differed in their response to developmental cues. Northern populations have an obligate diapause strategy and southern populations' development times differ in response to temperature, indicating local variation in response to environmental conditions. Populations differed in wing morphology (size, shape and melanisation) but this was not related to latitude. Experimental determination of heating rates in different basking positions and thoracic temperature at take-off revealed no strong relationships of the morphological characteristics with heating or cooling rates and an indication of relationship with PGI alleles. It is suggested that m comparison to larger butterflies morphological variation IS unconstrained by thermal requirements. The persistence and widespread occurrence of this butterfly may be a consequence of the variability of traits within this butterfly.

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11

Medeiros, Elana Carolina de Souza. "Capacidade de carga e percepção ambiental da Praia do Icaraí - Caucaia - CE". reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/11499.

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MEDEIROS, E. C. de S. Capacidade de carga e percepção ambiental da Praia do Icaraí - Caucaia - CE. 2012. 181 f. Dissertação (mestrado em Ciências Marinhas Tropicais) - Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2012.
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The present work aimed to evaluate the leisure sustain capacity of Icaraí beach, located at the city of Caucaia – CE, using the Phisic Charge Capacity (number of people which a beach can physically accommodate) and Social Charge Capacity (individual perception of the beach crowding), for the purpose of estimate an adequate visitors number that wouldn‟t increase the already existing anthropic pressure. The methodological procedure used was collecting, elaborating and analyzing data using field measurement techniques (to estimate the occupied area), number of people and infra structure counting and photo-shooting (to monitorate accurately the influx of beach users), as well as 500 interviews with the Icaraí beach users to obtain the usual perception and behavior towards the actual reality of the beach. The results show a charge capacity still compatible with the tolerable saturation level. Although, in some spots, during “rush” hours, such capacity reaches saturation levels, with critical signs of unbearable people concentration and thus spoiling the users‟ experience quality, whom declared prefer beaches with reduced congestion. This work contribution lays in produce a study about a beach charge capacity unpublished in Ceará. Such studies help decision taking in local management plans which take into consideration the costal organization in order to balance the environmental preservation and commercial development in the local beautiful beaches, Ceará‟s priceless natural heritage.
O presente trabalho visou avaliar a capacidade de suporte recreativo da Praia do Icaraí, localizada no município de Caucaia – CE, através dos Métodos de Capacidade de Carga Física (número de indivíduos que uma praia pode acomodar fisicamente) e Capacidade de Carga Social (percepção dos indivíduos em função do congestionamento de pessoas da praia), a fim de estimar um número adequado de visitantes que não aumente a pressão antrópica já existente na área. O procedimento metodológico foi o da coleta, elaboração e análise de dados, usando técnicas de medidas de campo (para estimar a área ocupada pelos usuários), contagens do número de pessoas e equipamentos de infra-estrutura e fotofilmagem (monitorar com rigor o fluxo de usuários da praia). Além de 500 entrevistas com os usuários da Praia do Icaraí, com o intuito de se obter a percepção e comportamento a respeito da realidade atual da mesma. Os resultados mostram uma capacidade de carga ainda com nível de saturação tolerável. Porém, alguns pontos, em momentos de “pico”, essa capacidade passa a atingir níveis de saturação, já com sinais críticos de concentração de pessoas, prejudicando a qualidade da experiência dos usuários que declaram preferências por praias de congestionamento reduzido. A contribuição deste trabalho está em produzir um estudo inédito no estado do Ceará sobre capacidade de carga de uma praia. Tais estudos auxiliam nas tomadas de decisões em planos de gerenciamento local que priorizem a organização do espaço litorâneo, buscando um equilíbrio entre preservação e exploração em prol de um patrimônio natural inestimável, que são as belas praias do litoral cearense.

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12

Kochanek, Izabela. "Analysis of neutral pions from vµ CC CNGS interactions in the ICARUS detector". Doctoral thesis, Katowice : Uniwersytet Śląski, 2015. http://hdl.handle.net/20.500.12128/5906.

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The aim of the thesis is the study of the electromagnetic showers and neutral mesons in the ICARUS T600 Liquid Argon Time Projection Chamber. To accurately reconstruct energy of electromagnetic showers, different corrections to the collected charge are needed. In this thesis the author calibrated the energy reconstruction with a set of corrections, most of which are not present in the official ICARUS reconstruction software. For this goal, the simulation package FLUKA was extensively used in order to study the ionization quenching and the shower containment in the detector. As a result the reconstructed invariant ⇡0 masses are distributed compactly (" = 12 MeV/c2) with a best value equal to 134.5 ± 1.5 ± 4.2 MeV/c2. Moreover, other results on low energy electromagnetic showers in Liquid Argon were found which include the longitudinal profile parametrization, the conversion distance measurement and the ionization losses for 1 and 2 m.i.p. particles. This latest point is interesting for the e CC events selection from ⌫μ NC background.

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13

Langston, Sara M. "Reimagining Icarus: Defining the physical, cultural, legal and ethical parameters for human spaceflight". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15706.

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Commercial human spaceflight inherently raises numerous medical, legal and ethical considerations with regard to the health and safety of civilian spaceflight participants (SFPs) and commercial crew. Nascent and emerging space companies are currently proposing a diverse range of commercial suborbital, orbital and eventually point-to-point transportation services that challenge the status quo of transportation service providers today. Bioethical and legal issues therefore arise throughout the course of private/commercial (nongovernmental) spaceflight activities to include preflight selection procedures, medical monitoring, and informed consent among others. In addition, concerns involving medical, technological and scientific uncertainty raise issues in developing effective governance for spaceflight. This is particularly evident with regard to how to regulate innovative space technologies and mission architectures, establishing appropriate risk assessment and management procedures, incorporating moral decision-making frameworks into commercial spaceflight operations, and understanding the cultural values and moral relationships inherent to these space actors, the general public, and prospective space activities. This thesis raises pertinent issues, arguments, implications and applicable approaches for commercial human spaceflight to better assist in establishing a foundation for dynamic and forward-looking ethical, legal and practical frameworks on spaceflight and human expansion into space.

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14

Esteves, Anna Maria Pereira. "Dramaturgie et mémoire : le groupe Icaros do Vale, dans le Minas Gerais ( Brésil)". Thesis, Paris 10, 2012. http://www.theses.fr/2012PA100122.

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Cette thèse construit une réflexion sur les liens entre dramaturgie et mémoire, dans “l’écriture de la scène” du groupe de théâtre « Icaros do Vale », dans le Minas Gerais (Brésil), considérant que le “mode populaire de la production artistique” d'Icaros do Vale s’inscrit dans l’assertion lukacsienne de l’universalité esthétique de la représentation, même apparemment ancrée dans le particulier et le “processus de la vie réelle”. L’analyse inclut une réflexion sur la culture populaire et, plus spécifiquement dans le domaine du théâtre, sur les modes de recréation, dans l’écriture de la scène, de ces représentations exemplaires. La redéfinition idéologique de ce qui est appelé “culture populaire” inclut un questionnement de l’authenticité et de la légitimité de sa “récupération mémorielle”, sans la condamner à une simple reproduction de stéréotypes et aussi sans considérer comme art authentique les démonstrations colonisées par l’industrie de la culture. Le dévoilement des implications sociales, politiques, idéologiques et esthétiques qui imprègnent le groupe Icaros do Vale exige une connaissance de la vie de la région de Jequitinhonha, son occupation et son peuplement à partir de 1789 et les modes de maintien des fêtes traditionnelles, des coutumes, des légendes, des chants anciens et du théâtre populaire. A partir de cette genèse des manifestations culturelles, il sera possible d’étudier l’émergence et la réémergence, dans le temps, de cette diversité et de cette richesse culturelle. Et de tenter d’éclaircir l’apparent paradoxe que représente l’existence de ce groupe théâtral de grande qualité dans une région au statut socioéconomique aussi précaire que le Vale do Jequitinhonha
The object of this thesis is to reflect on the dramaturgy and memory of Ícaros do Vale theater group, which has completed fifteen years of political and aesthetical resistance in Vale do Jequitinhonha, Minas Gerais. For that purpose, the following investigation was carried out in order to investigate if the “popular method of artistic production” of Ícaros do Vale, known for its commitment to the “process of real life”, elevates itself to universality, even though it is linked to the representation of something in particular. The task consisted of an analysis beyond the efforts commonly found on studies about representation on popular culture and, specifically on the field of the theater produced by Ícaros do Vale, object of this research, about the efforts to “rescue” their own “exemplary” representations through their scenic procedures. The representation of the popular culture of Minas Gerais on the performances of the group will not be legitimized with redeeming authenticity, nor will it be condemned as mere reproduction of the stereotype, as it is usual on a discourse that considers genuine art the manifestations largely colonized by the cultural industry

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15

Lehtinen, Tuomas. "Internal Combustion of an Asteroid Recorded Using a Spacecraft (ICARUS) : Mission Definition Review". Thesis, Luleå tekniska universitet, Institutionen för system- och rymdteknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-76148.

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16

Dequal, Daniele. "Wide energy range trigger and development of new electronics for ICARUS LAr-TPC". Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423599.

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The ICARUS-T600 detector, with its 470 tons of active mass, is the largest Liquid Argon TPC (LAr-TPC) ever built, and is now currently operating in the LNGS underground laboratory, detecting cosmic rays events after 3 years of data taking with the CERN Neutrinos to Gran Sasso beam. Its excellent calorimetric resolution and topol- ogy reconstruction capabilities permit a wide physics program, which goes from nucleon decay to the study of the oscillation of the neutrinos from the CNGS beam. The events collected differ both for energy deposition (ranging from tens of MeV to tens of GeV) and for topology. To get a fully-efficient detection of the interesting events it is thus necessary to exploit all available sources in the trigger system: the scintillation light, the charge signal on wires and timing information (for beam-related events). For the 2010-2013 data taking a primary trigger, based on the signal from the photomultipliers placed inside the detector, has been set up. To enhance the efficiency of this setup for CNGS neutrino events, a particular effort has been addressed to the development of a time synchronization with the spill extraction, which allowed to reduce the trigger threshold in coincidence with the neutrino arrival time. To check the PMT efficiency for the CNGS events, an alternative minimum biasing trigger has been also developed, which is based on the time synchronization as well as on the analysis of the charge deposition on the TPC wires. A full efficiency and a rejection of more than 103 have been reached with this trigger. To further increase the PMT trigger efficiency on non beam related events, an hit finding algorithm has been implemented in a hardware device, and is now taking data in steady condition. First results of this recently installed system, have shown an increase of the overall trigger efficiency on the sub-GeV region, which is of particular interest in view of the study of nucleon decay as well as on the low energy tail of the atmospheric neutrons. Finally ICARUS solved the anomaly reported by the OPERA collaborations on the superluminar neutrino velocity, by performing a high precision measurement of the neutrino time of flight from CERN to LNGS, resulting in perfectly agreement, within the experimental resolution, with the light velocity.
Il rivelatore ICARUS T-600, con una massa attiva complessiva di 470 tonnellate, rappresenta la più grande camera a proiezione temporale ad argon liquido (LAr-TPC) mai costruita, ed è attualmente in presa dati ai LNGS, rilevando raggi cosmici dopo i tre anni dedicati alla misura degli eventi dal fascio di neutrini CNGS. La sua eccellente risoluzione calorimetrica, unita alla possibilità di ricostruzione topologica degli eventi, permette un ampio programma di fisica, che spazia dallo studio del decadimento dei nucleoni all’osservazione delle oscillazioni sul fascio CNGS. Gli eventi raccolti differiscono sia per energia depositata nel rivelatore (la quale varia da decine di MeV a decine di GeV) sia per topologia degli eventi. Per ottenere una piena efficienza sugli eventi di interesse è necessario dunque sfruttare tutte le sorgenti di trigger in un unico sistema: la luce di scintillazione, il segnale di carica raccolto dai fili della TPC e la sincronizzazione temporale (per eventi di fascio). Per la presa dati 2010-13 è stato sviluppato un trigger primario, basato sul segnale raccolto dai fotomoltiplicatori installati all’interno del rivelatore. Per aumentare l’efficienza di questo sistema per gli eventi CNGS, un particolare sforzo è stato rivolto allo sviluppo di un sistema di sincronizzazione con l’estrazione del fascio, che ha permesso di ridurre le soglie di rivelazione in coincidenza col tempo di arrivo dei neutrini. La conferma dell’efficienza di questo sistema è stata ottenuta da un trigger alternativo, basato sull’analisi della carica depositata sui fili delle TPC. Una piena efficienza e una reiezione dei fondi superiore a 103 è stata raggiunta con questo sistema. Per migliorare ulteriormente l’efficienza del trigger da PMT per eventi non di fa- scio, un algoritmo di identificazione delle hit è stato implementato in un dispositivo hardware, ed è ora stabilmente in presa dati. I primi risultati di questo sistema installato di recente, hanno dimostrato un aumento di efficienza nella regione sub-GeV, la quale è di particolare interesse in vista degli studi sul decadimento del nucleone, così come sulla coda a bassa energia dello spettro dei neutrini atmosferici. Infine ICARUS ha risolto l’anomalia riportata dalla collaborazione OPERA riguardo alla velocità superluminare del neutrino, misurano con alta precisione il tempo di volo del neutrino dal CERN ai LNGS, concludendo con un perfetto accordo, entro la risoluzione sperimentale, con la velocità della luce

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17

Dancourt, Michèle. "Dédale et Icare : situation du mythe dans la culture européenne". Paris 3, 1994. http://www.theses.fr/1994PA030137.

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Ce mythe, malgre son apparente dispersion, rejoint certains vecteurs de la culture europeenne, par l'eclairee en un point focal : le statut de la "techne". En effet, l'histtoire de ce mythe de l'artiste fait surgir, aux cotes de l'artisan dedale, ses feux fils qui deviennent deux autres figures d'artistes: icare, au xixe siecle, chercheur d'absolu voue a la chute, et le minotaure au xxe siecle, face d'ombre sacrificielle du demiruge. Longtemps l'europe a accoulte le pere (le createur d'images est presque absent de la representation picturale) et manifeste sa fascination pour le fils: icare, embleme de demesure, au centre d'un reseau serre d'images, prend d'autant plus de relief que signes scripturaures et iconiques se font parfois echo. Paradoxalement, les peintres l'abandonnent au moment de crise ou, symbolisant a la fois le triomple de l'aeronautique et l'impuissance de l'artiste dans sa quete de sublimation, il incarne le divorce consomme entre art et technique. Icare devient meme la figure d'un lieu commun dont des interpretations burlesques et grotesques bousculent l'usage et l'usure. A travers les relectures du mythe affleure un scenario stable, d'une grande richesse symbolique, centre sur une demiurgie liee a la rivalite du pere et du fils et a la conquete d7un nom fetichise, ce qui suppose l'eviction de toute feminite et induit le renversement dangereux de la creativite en pulsion de destruction. Les autres invariants deploient tout un imaginaire dynamique et polysemique : devenir-animal (oiseau, taureau), corps cosmique, labyrinthe, danse envol, ebouissement et chute
This myth, in spite of its seeming dispersion, follows the vectors of european culture throwing light onto one focal point, the status of art. If we examine the history of this myth, we ses emerging on either side of the craftsman daedalus his two sons who are to evolve into artist figures themeselves : icarus in the nineteenth century in search of the absolute but destinde to fall and the minoteur in the twentieth century, the dark sacrificial side of the demiurge. European culture had long since occulted the father (the craftsman himself is virtually absent from any pictorial representation) and yet showed a marked fascination for the son icarus, whose hubristic tendancy makes him stand out from the mass of imagery all the more so since both inconic and written representation mirror each other. Paradoxically artists abandon him at a critical moment when, symbolising both the triumph of aeronautics and the failure of the quest for the sublime, he would seem to incarnate the divoprce betwwen art and technology. Icarus was to become a common place figure in interpretations which, breaking with tradition, were burlesque. Reading through the different interpretations of this myth, one can perceive a stable scenario which is richly symbolic and centres on the demiurge linking both father-son rivality and the creation of a fetishistic name; feminity is cast aside and creativity verges on destruction. The other common features of the myth open up a vivid, ambiguous imaginary wolrd

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18

Bouchet, Jullien. "Ingénierie de l'intéraction multimodale en entrée : approche à composants ICARE". Grenoble 1, 2006. http://www.theses.fr/2006GRE10228.

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Depuis les travaux fondateurs de R. Bolt« Mets ça là » combinant la voix et le geste, les modalités d'interaction se sont multipliés, diversifiés et améliorés. Les récents paradigmes d'interaction comme les interfaces tangibles incarnées ou la réalité augmentée, couplés aux progrès des systèmes de localisation, à la miniaturisation des dispositifs, à la qualité des réseaux sans fils, à l'amélioration de la reconnaissance de la parole ou de gestes ouvrent un vaste champ de possibilités d'interaction pour les systèmes multimodaux. Dans ce contexte, et bien que de nombreux systèmes multimodaux soient disponibles, leur développement et leur maintien restent encore des tâches difficiles, notamment par manque de réutilisabilité de l'existant. Ce travail de thèse aborde ce problème de conception et de développement pour la multimodalité en entrée (de l'utilisateur vers le système informatique). Nous décrivons un modèle conceptuel de la multimodalité qui organise dans un canevas unificateur les modalités et leurs formes de combinaison. Basé sur ce modèle, nous définissons une approche générique à composants logiciels, notée ICARE, facilitant et accélérant la conception, le développement et le maintien des interfaces multimodales. Nous démontrons l'apport de cette approche par l'outil ICARE qui est une opérationnalisation de notre approche à composants. Un éditeur graphique est fourni, simplifiant la phase d'assemblage des composants et générant automatiquement le code correspondant à l'interaction multimodale. Cinq systèmes multimodaux aux caractéristiques distinctes (systèmes de réalité augmentée, de virtualité augmentée et mobiles) ont été développés avec l'outil ICARE
The area of multimodal interaction has expanded rapidly since the seminal "Put that there" demonstrator of R. BoIt that combines speech and gesture. Ln parallel with the development of the Graphical User Interface technology, natural language processing and gesture recognition have made significant progress. Ln addition, recent interaction paradigms such as tangible and embodied user interfaces as weIl as augmented reality open a vast world of possibilities for interaction modalities. Significant achievements have been made in terms of both modalities and real multimodal systems. Although several muItimodal systems have been built, their design and development still remains a difficult task particularly because of a lack of reusability. Ln this thesis we address this problem of design and development for input multimodal interfaces (from the user to the system). We describe a conceptual model ofmultimodality as a unified framework for modalities and combinations of modalities. Based on this conceptual model, we define a generic component-based approach called ICARE which allows the easy and rapid design, development and maintenance of multimodal interfaces. We have developed the ICARE tool to prove the usefulness of our component-based approach. The ICARE tool is a graphical platform that enables the designer/developer to graphically manipulate and assemble ICARE software components in order to specify the muItimodal interaction. From this specification, the code of the multimodal interaction is automatically generated. Five multimodal systems with different characteristics (augmented virtualitv/realitv, mobile systems) have been develooed with the ICARE too1

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19

PETRY, Helô. "ICARE: um sistema de recomendação de especialistas sensível a contexto". Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/2677.

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Freqüentemente, pessoas precisam, para realização de sua tarefa, de determinado conhecimento que só pode ser obtido através de experiência e prática, que elas podem não possuir. Elas podem economizar tempo e esforço se puderem interagir, informalmente, com outras pessoas que já possuam esse conhecimento. A colaboração informal facilita a troca de experiências e permite o reuso de conhecimento entre os indivíduos. Sistemas de Recomendação de Especialistas (SRE) podem ser usados para promover a colaboração informal através da identificação de especialistas que possam ajudar indivíduos na realização de suas tarefas. No entanto, os SRE existentes são centrados no especialista, em vez do usuário, e não levam em consideração o contexto dos envolvidos na recomendação. O objetivo deste trabalho é o desenvolvimento de um SRE que utiliza o contexto do usuário e do especialista para fazer recomendações mais ajustadas às necessidades do primeiro e, dessa maneira, facilitar a colaboração informal: o ICARE (Intelligent Context Awareness for Recommending Experts). Para tanto, é preciso entender o contexto das pessoas e como determinar as suas especialidades, definir as informações contextuais que devem ser consideradas e um processo de aquisição das especialidades e, finalmente, definir uma heurística de classificação dos especialistas a recomendar de acordo com o contexto de especialista e usuário. As principais contribuições deste trabalho são a inserção de sensibilidade a contexto no processo de recomendação de especialistas, uma ausência identificada nos sistemas existentes, e o desenvolvimento de um SRE sensível ao contexto. No experimento realizado, a sensibilidade a contexto do ICARE foi aprovada e os resultados gerados pelas recomendações realizadas foram bem avaliados pelos participantes

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20

Silveira, Bruno Rodrigues da. "O Morar Permanente na Praia: Moradia e Vilegiatura na Localidade Praiana do IcaraÃ - CE". Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6831.

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Esta dissertaÃÃo apresenta uma reflexÃo sobre o processo de transformaÃÃo das residÃncias de vilegiatura marÃtima em residÃncias permanentes no litoral de Caucaia tendo como estudo de caso a praia do IcaraÃ O processo de transmutaÃÃo no espaÃo litorÃneo Ã regido pelos fatores de transformaÃÃo econÃmico e social da RMF A praia do IcaraÃ por se configurar em Ãrea de ocupaÃÃo densa de domicÃlios e prÃxima da zona oeste de Fortaleza configura-se numa localidade propÃcia para moradia permanente Utilizamos na investigaÃÃo a aplicaÃÃo de questionÃrios em 51 condomÃnios e 36 casas no IcaraÃ No primeiro os questionÃrios foram aplicados nos sÃndicos e porteiros dos imÃveis e no segundo diretamente aos moradores Foram realizadas tambÃm anÃlises nos resultados do Censo DemogrÃfico do IBGE 2010 e pesquisas no banco de dados do Jornal O Povo Esta pesquisa revela um aumento de apartamentos e casas ocupadas por moradores nos Ãltimos dez anos resultado da expansÃo urbana para o litoral de Caucaia e da aÃÃo do mercado imobiliÃrio que passa a investir em moradias Alguns fatores ajudam a dinamizar esse crescente setor no IcaraÃ como: melhoramentos de vias de acesso e transportes rodoviÃrios; a presenÃa de um setor comercial ativo na localidade; queda nos preÃos dos terrenos e dos imÃveis ocasionadas pelos processos erosivos da praia; implantaÃÃo do Porto do PecÃm; e principalmente incentivos para financiamento de imÃveis atravÃs do programa federal de habitaÃÃo â Minha Casa Minha Vida
This dissertation shows careful consideration about the process of transformation of the residences used as second homes or beach houses into permanent residences in the coast of Caucaia having as study case beach of IcaraÃ The process of transmutation in the coastal area is conducted by economical and social transformation factors of RMF Being in a dense occupation housing area and near the west zone of Fortaleza beach of IcaraÃ is an appropriate location for permanent residence In the investigation we applied questionnaires in 51 condominiums and 36 houses in IcaraÃ At first the questionnaires were applied to care-takers and porters and at the second directly to the residents Analysis on the results of the 2010 IBGEâs demographic census and research on âO Povoâ newspaper data bank were also carried out This research reveals an increase on the occupation rate of houses and apartments in the last 10 years This was a consequence of urban expansion to the coast of Caucaia and real estate market actions and investments in housing Some factors helped boosting this crescent sector in IcaraÃ such as: improvement on access roads and transportation; the presence of an active commercial sector in the location; decrease on prices of land and properties caused by the erosion processes at the beach; PecÃm port creation; and mainly incentives for financing property buying through the federal housing program â Minha Casa Minha vida

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Silveira, Bruno Rodrigues da. "O Morar Permanente na Praia: Moradia e Vilegiatura na Localidade Praiana do Icaraí - CE". reponame:Repositório Institucional da UFC, 2011. http://www.repositorio.ufc.br/handle/riufc/7538.

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SILVEIRA, B. R. O Morar Permanente na Praia: Moradia e Vilegiatura na Localidade Praiana do Icaraí - CE. 2011. 127 f. Dissertação (Mestrado em Geografia) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2011.
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This dissertation shows careful consideration about the process of transformation of the residences used as second homes or beach houses into permanent residences in the coast of Caucaia having as study case beach of Icaraí The process of transmutation in the coastal area is conducted by economical and social transformation factors of RMF Being in a dense occupation housing area and near the west zone of Fortaleza beach of Icaraí is an appropriate location for permanent residence In the investigation we applied questionnaires in 51 condominiums and 36 houses in Icaraí At first the questionnaires were applied to care-takers and porters and at the second directly to the residents Analysis on the results of the 2010 IBGE’s demographic census and research on ‘O Povo’ newspaper data bank were also carried out This research reveals an increase on the occupation rate of houses and apartments in the last 10 years This was a consequence of urban expansion to the coast of Caucaia and real estate market actions and investments in housing Some factors helped boosting this crescent sector in Icaraí such as: improvement on access roads and transportation; the presence of an active commercial sector in the location; decrease on prices of land and properties caused by the erosion processes at the beach; Pecém port creation; and mainly incentives for financing property buying through the federal housing program – Minha Casa Minha vida
Esta dissertação apresenta uma reflexão sobre o processo de transformação das residências de vilegiatura marítima em residências permanentes no litoral de Caucaia tendo como estudo de caso a praia do Icaraí O processo de transmutação no espaço litorâneo é regido pelos fatores de transformação econômico e social da RMF A praia do Icaraí por se configurar em área de ocupação densa de domicílios e próxima da zona oeste de Fortaleza configura-se numa localidade propícia para moradia permanente Utilizamos na investigação a aplicação de questionários em 51 condomínios e 36 casas no Icaraí No primeiro os questionários foram aplicados nos síndicos e porteiros dos imóveis e no segundo diretamente aos moradores Foram realizadas também análises nos resultados do Censo Demográfico do IBGE 2010 e pesquisas no banco de dados do Jornal O Povo Esta pesquisa revela um aumento de apartamentos e casas ocupadas por moradores nos últimos dez anos resultado da expansão urbana para o litoral de Caucaia e da ação do mercado imobiliário que passa a investir em moradias Alguns fatores ajudam a dinamizar esse crescente setor no Icaraí como: melhoramentos de vias de acesso e transportes rodoviários; a presença de um setor comercial ativo na localidade; queda nos preços dos terrenos e dos imóveis ocasionadas pelos processos erosivos da praia; implantação do Porto do Pecém; e principalmente incentivos para financiamento de imóveis através do programa federal de habitação – Minha Casa Minha Vida

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22

Pinto, Leandro Israel. "ICARU-FB: uma infraestrutura de software aderente à norma IEC 61499". Universidade do Estado de Santa Catarina, 2014. http://tede.udesc.br/handle/handle/2042.

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The IEC 61499 standard defines a development model for industrial automation and control, it defines a visual language that can facilitate the implementation of distributed control system. This work presents the proposal and implementation of ICARU-FB, an Open Source multi-platform environment, capable of running the function blocks defined in IEC 61499 on architectures with few computational resources. A virtual machine was designed and implemented to perform networks of function blocks on 8-bit platforms with minimal resources. It was also ported to run on a 64-bit computer. Two case studies were performed in order to verify compliance with IEC 61499. Through the case studies, it was verified that it is possible to meet the requirements of the standard, such as configurability, interoperability and portability. The case studies also demonstrated the ability of the environment to reconfigure the software at runtime.
A norma IEC 61499 define um modelo de desenvolvimento para automação e controle industrial, ela estabelece uma linguagem visual que pode facilitar a implementação de sistemas de controle distribuídos. Esse trabalho apresenta a proposta e implementação do ICARU-FB, um ambiente Open Source multiplataforma, que é capaz de executar a linguagem definida na norma IEC 61499 em arquiteturas com poucos recursos computacionais. Uma maquina virtual foi projetada e implementada para executar redes blocos de funções em plataformas de 8 bits com o mínimo de recursos. Ela também foi portada para executar em um computador de 64 bits. Dois estudos de caso foram realizados a fim de verificar a conformidade com a norma IEC 61499. Através desses estudos de caso, foi verificado que é possível atender aos requisitos da norma IEC 61499, como configurabilidade, interoperabilidade e portabilidade. Os estudos de caso também demonstraram a habilidade do ambiente de reconfigurar o software em tempo de execução.

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23

Fonseca, Hugo Alexander Oliveira Maia da. "ICARUS - Busca e salvamento utilizando deteção sonar [sistema de deteção de náufragos com imagens sonar]". Master's thesis, Escola Naval, 2015. http://hdl.handle.net/10400.26/10848.

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Resumo O CINAV no âmbito do projeto ICARUS, está a colaborar no desenvolvimento de veículos não tripulados para busca e salvamento podendo estes ser uma valiosa ferramenta para salvar vidas humanas. Tendo a Marinha Portuguesa UUV para guerra de minas, surgiu a ideia de usar estes veículos também para na vertente de Busca e Salvamento. Em situações de naufrágio em alto mar, o corpo humano à deriva fica com cerca de noventa porcento submerso, torna-se pertinente o desenvolvimento de um sistema capaz identificar os náufragos usando imagens recolhidas por sonares, colocados nos UUV, mas apontados para a superfície. Ao longo dos últimos anos, tem-se assistido ao desenvolvimento de inúmeros métodos associados à deteção de objetos em imagens digitais. Nesta tese é feita uma revisão bibliográfica das várias técnicas utilizadas para classificar objetos em imagens e são apresentados alguns conceitos na área de processamento de imagens, com enfase no reconhecimento de padrões. Nesta tese é descrito o processo de recolha de imagens, efetuado relativamente as posições prováveis de se encontrar um corpo à deriva. São estabelecidos os parâmetros para o Algoritmo aplicado SURF (Speed-Up Robust Features) que permitem uma melhor eficácia ao nível da classificação da existência de um náufrago à deriva.

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24

TORTI, MARTA. "Effects of electric and magnetic fields on the event reconstruction in the ICARUS T600 detector". Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203315.

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In recent years, a number of anomalies in neutrino oscillation scenario were observed, that point out to possible non-standard oscillations which could imply the existence of a fourth (or more) sterile neutrino. Its existence, or absence, calls for a definitive clarification with new data. In particular, the Short Baseline Neutrino program at FNAL, will exploit three Liquid Argon Time Projection Chamber (LAr TPC) detectors along the Booster Neutrino Beamline. Each detector has different mass and a different position: the near detector SBND is the smallest, the intermediate detector MicroBooNE is the medium sized while the biggest one is the far detector, the ICARUS T600. This Ph.D. thesis is focused on the ICARUS T600 detector, the largest LAr TPC ever built, which concluded successfully the operation at LNGS in Italy. Here it was exposed at underground conditions to the CNGS beam to study oscillations. After the CNGS shut down, the detector continued taking data with cosmic rays until it was de-commissioned and transported to CERN, where it is now under refurbishment, before moving to FNAL. In a LAr TPC, when a charged particle crosses the detector, ionizing electrons are drifted towards the wire anode planes, where they are collected providing two spatial coordinates of the track; arrays of PMTs detect scintillation light, providing the measurement of the absolute time of occurrence that, combined with the knowledge of the drift velocity, permits the determination of the third coordinate of the track, that along the drift direction. The goal of the ICARUS reconstruction procedure is to extract, in an accurate way, all the physical information contained in the wire and PMT output signals, to build a complete 3D spatial and calorimetric picture of the event. To have this faithful event reconstruction, it is mandatory to determine wire and drift coordinates accurately and so it is essential to understand everything that could distort the information. The uniformity of electric field is essential in order to ensure a uniform drift velocity and thus the proportionality between drift time and drift coordinate. Electric field distortions may arise by a local accumulation, along the drift path, of positive ions, which are drifted towards the cathode more slowly than the electrons. This accumulation is emphasised by high interaction rate, given for example by high cosmic ray flux. This problem, called space charge, could be present at FNAL, where the ICARUS detector will be placed at shallow depths. In order to understand the influence of this effect in track reconstruction, a data sample is analysed, collected when the detector was at surface condition for a test run in Pavia. In the thesis are described the parameters used to study space charge effects in the ICARUS detector and the obtained results are illustrated. As stated before, the drift coordinate precision is derived by the electrons drifted towards the wire planes and it is affected by several factors, such as the diffusion. To evaluate the diffusion parameter, a dedicated run with different electric field values was performed collecting cosmic rays at the end of LNGS run. The analysis of these data samples is pointed out, considering the dependence of the width of the signal registered by the TPC. The ICARUS Collaboration is also involved in a long time project, called DUNE (Deep Underground Neutrino Experiment): it will be a long baseline experiment, with modular kiloton LAr-TPCs, to be built in the next 20 years. The T600 could be used as Near Detector, once provided with a magnetic field for particle momentum measurements and charged particle identification. The presence of a magnetic field introduces new parameters and possibilities for the reconstruction procedure. In this framework, an algorithm is developed, in order to discriminate between electron neutrino and electron antineutrino, considering their interaction products.
In recent years, a number of anomalies in neutrino oscillation scenario were observed, that point out to possible non-standard oscillations which could imply the existence of a fourth (or more) sterile neutrino. Its existence, or absence, calls for a definitive clarification with new data. In particular, the Short Baseline Neutrino program at FNAL, will exploit three Liquid Argon Time Projection Chamber (LAr TPC) detectors along the Booster Neutrino Beamline. Each detector has different mass and a different position: the near detector SBND is the smallest, the intermediate detector MicroBooNE is the medium sized while the biggest one is the far detector, the ICARUS T600. This Ph.D. thesis is focused on the ICARUS T600 detector, the largest LAr TPC ever built, which concluded successfully the operation at LNGS in Italy. Here it was exposed at underground conditions to the CNGS beam to study oscillations. After the CNGS shut down, the detector continued taking data with cosmic rays until it was de-commissioned and transported to CERN, where it is now under refurbishment, before moving to FNAL. In a LAr TPC, when a charged particle crosses the detector, ionizing electrons are drifted towards the wire anode planes, where they are collected providing two spatial coordinates of the track; arrays of PMTs detect scintillation light, providing the measurement of the absolute time of occurrence that, combined with the knowledge of the drift velocity, permits the determination of the third coordinate of the track, that along the drift direction. The goal of the ICARUS reconstruction procedure is to extract, in an accurate way, all the physical information contained in the wire and PMT output signals, to build a complete 3D spatial and calorimetric picture of the event. To have this faithful event reconstruction, it is mandatory to determine wire and drift coordinates accurately and so it is essential to understand everything that could distort the information. The uniformity of electric field is essential in order to ensure a uniform drift velocity and thus the proportionality between drift time and drift coordinate. Electric field distortions may arise by a local accumulation, along the drift path, of positive ions, which are drifted towards the cathode more slowly than the electrons. This accumulation is emphasised by high interaction rate, given for example by high cosmic ray flux. This problem, called space charge, could be present at FNAL, where the ICARUS detector will be placed at shallow depths. In order to understand the influence of this effect in track reconstruction, a data sample is analysed, collected when the detector was at surface condition for a test run in Pavia. In the thesis are described the parameters used to study space charge effects in the ICARUS detector and the obtained results are illustrated. As stated before, the drift coordinate precision is derived by the electrons drifted towards the wire planes and it is affected by several factors, such as the diffusion. To evaluate the diffusion parameter, a dedicated run with different electric field values was performed collecting cosmic rays at the end of LNGS run. The analysis of these data samples is pointed out, considering the dependence of the width of the signal registered by the TPC. The ICARUS Collaboration is also involved in a long time project, called DUNE (Deep Underground Neutrino Experiment): it will be a long baseline experiment, with modular kiloton LAr-TPCs, to be built in the next 20 years. The T600 could be used as Near Detector, once provided with a magnetic field for particle momentum measurements and charged particle identification. The presence of a magnetic field introduces new parameters and possibilities for the reconstruction procedure. In this framework, an algorithm is developed, in order to discriminate between electron neutrino and electron antineutrino, considering their interaction products.

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25

Fava, Angela. "L'esperimento ICARUS: dal T600 alle grandi masse. Studio e sviluppo di un sistema di trigger". Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427065.

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The ICARUS-T600 detector at LNGS, in final commissioning after 20 years of R&D, is the first large mass Liquid Argon TPC (LAr-TPC) which, thanks to its great energy resolution and completely uniform imaging, is expected to give original contributions to Particle Physics in the fields of neutrino oscillations and p-decay search. Moreover the start-up of this experiment represents an important test of the Liquid Argon technology toward the realization of any much larger LAr-TPC detector. This kind of experiments requires an efficient and multi-purpose trigger system, capable of an high accuracy identification of the detector regions interested by the event, useful for data reduction. In ICARUS-T600 the signal that better matches these requests is the one of the TPC wires. Thus two possible ways of extracting the TPC wires signal have been studied with the aim of realizing a first level local trigger system: one is based on the AWS signal, analog sum of signals collected by 32 consecutive wires, while the other one applies a double-rebinning algorithm (DR-slw) to each wire signal. Both these solutions have been implemented on dedicated boards, installed in a small LAr-TPC at LNL, and tested: the obtained results, especially concerning the DL-slw algorithm, are extremely positive and suggest the employment of this kind of internal trigger signal in ICARUS-T600 and in forthcoming experiments using huge LAr-TPC detectors.
Il rivelatore ICARUS-T600, installato ai LNGS e prossimo alla presa dati, e' la prima grande TPC ad Argon liquido (LAr-TPC): grazie alla sua ottima risoluzione in energia e alle capacità di imaging sara' in grado di dare contributi originali nell'ambito della fisica del neutrino e del decadimento del nucleone, nonostante la massa ridotta. La messa in funzione di questo rivelatore rappresenta inoltre, dopo 20 anni di R&D, un importante banco di prova della tecnica delle LAr-TPC in vista di futuri esperimenti dedicati alla ricerca di eventi rari con rivelatori ad Argon liquido di grande massa. Requisito essenziale per apparati di questo tipo e' un sistema di trigger efficiente e flessibile, in grado di limitare l'acquisizione alle sole regioni del rivelatore interessate dall'evento; il segnale che meglio si presta a questo scopo e', in ICARUS-T600, quello dei fili delle TPC. Sono state studiate, pertanto, due possibili strategie per l'estrazione di un segnale di trigger locale di primo livello dai fili della TPC: una e' basata sul segnale AWS somma analogica dei segnali di 32 canali consecutivi, mentre l'altra sfrutta un algoritmo di filtro medio di doppio rebinning (DR-slw) applicato ai segnali dei singoli fili. Entrambe le soluzioni sono state implementate hardware su opportune schede che sono state installate in una piccola LAr-TPC ai LNL per verificarne funzionalita' e prestazioni: questi test hanno fornito risultati molto incoraggianti, soprattutto per quanto riguarda il DR-slw, che prospettano la possibilita' di utilizzo di un trigger interno di questo tipo per la ricerca di eventi isolati in rivelatori ad Argon liquido di grande massa.

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26

Hartwig, Judith. "”Well, it’s not a proper story if everyone’s miserable” : Intertextualitet och hybriditet i The Icarus Girl". Thesis, Uppsala universitet, Litteraturvetenskapliga institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316543.

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Mena, Marcelo Andrés. "Improving emissions inventories in North America through systematic analysis of model performance during ICARRT and MILAGRO". Diss., University of Iowa, 2007. https://ir.uiowa.edu/etd/153.

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During 2004 and 2006 the University of Iowa provided air quality forecast support for flight planning of the ICARTT and MILAGRO field campaigns. A method for improvement of model performance in comparison to observations is showed. The method allows identifying sources of model error from boundary conditions and emissions inventories. Simultaneous analysis of horizontal interpolation of model error and error covariance showed that error in ozone modeling is highly correlated to the error of its precursors, and that there is geographical correlation also. During ICARTT ozone modeling error was improved by updating from the National Emissions Inventory from 1999 and 2001, and furthermore by updating large point source emissions from continuous monitoring data. Further improvements were achieved by reducing area emissions of NOx y 60% for states in the Southeast United States. Ozone error was highly correlated to NOy error during this campaign. Also ozone production in the United States was most sensitive to NOx emissions. During MILAGRO model performance in terms of correlation coefficients was higher, but model error in ozone modeling was high due overestimation of NOx and VOC emissions in Mexico City during forecasting. Large model improvements were shown by decreasing NOx emissions in Mexico City by 50% and VOC by 60%. Recurring ozone error is spatially correlated to CO and NOy error. Sensitivity studies show that Mexico City aerosol can reduce regional photolysis rates by 40% and ozone formation by 5-10%. Mexico City emissions can enhance NOy and O3 concentrations over the Gulf of Mexico in up to 10-20%. Mexico City emissions can convert regional ozone production regimes from VOC to NOx limited. A method of interpolation of observations along flight tracks is shown, which can be used to infer on the direction of outflow plumes. The use of ratios such as O3/NOy and NOx/NOy can be used to provide information on chemical characteristics of the plume, such as age, and ozone production regime. Interpolated MTBE observations can be used as a tracer of urban mobile source emissions. Finally procedures for estimating and gridding emissions inventories in Brazil and Mexico are presented.

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28

Lundell, Åse. ""Jess-who-wasn't-Jess" : Double Consciousness and Identity Construction in Helen Oyeyemi's The Icarus Girl". Thesis, Karlstads universitet, Estetisk-filosofiska fakulteten, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-6242.

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Abstract During the last decade many female writers of British decent have focused on identity construction and coming of age. These writers have been especially interested in exploring how people living in the diaspora are trying to cope with their ambivalent feelings towards their mixed cultural heritage. Helen Oyeyemi's The Icarus Girl is one of these novels. The novel depicts a young girl's struggle with the dualism within her, being both British and Nigerian, that threatens to dissolve her self-identity. This essay will explore how The Icarus Girl deals with the theme “double consciousness” (imposed binaries) and how the narrative's structure and stylistic devices enable the story to be read (interpreted) from two different perspectives, thus the narrative's structure offers an ambiguous double reading that corresponds to Jessamy's unresolved doubleness. The first reading suggests that the traumatic experience of “double consciousness“ is left in a status quo, or even being fatal, which in the essay is called the Western reading. The second reading suggests a recovery, i.e. that the young protagonist comes to terms with her mixed cultural heritage, the so-called West-African reading. In pursuing this aim I discuss how “double consciousness” in this novel is a traumatic state of mind transferred from mother to daughter, but also how stylistic devices, belonging to the genre of the fantastic, are used to emphasize the theme and make possible the two different readings.

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Farnese, Christian. "STUDIO DEGLI ALGORITMI DI RICOSTRUZIONE DI EVENTI DI NEUTRINO IN ICARUS T600 E IDENTIFICAZIONE DI e/pi0". Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3422382.

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ICARUS T600 is a large mass detector with a high spatial resolution, devoted to the experimental study of neutrinos (both cosmic and from the CNGS beam), matter stability and, more generally, rare phenomena. The most important features of this detector are the high granularity, similar to a bubble chamber, and a good calorimetric capability. These features are obtained with an electronic detector using a large volume of a homogeneous medium. Thanks to its information redundancy and particle identification capability, ICARUS is ideal for the study of neutrinos, since it allows to identify the interacting neutrino flavour. nutau interactions are recognized by means of kinematic selections a la NOMAD, while the particle ID capabilities allow to distinguish with high efficiency and negligible contaminations the nue CC from the numu NC, by studying the electrons emitted in the primary vertex. Some algorithms have been developed in order to distinguish these two classes of interactions, by discriminating between signals produced by electrons and neutral pions. In order to clearly distinguish such signals, a good energy reconstruction is necessary; a precise calibration of the DAQ electronic channels and an accurate measurement of electron lifetime in Liquid Argon are therefore necessary. In the present thesis, the methods that have been developed both for the calibration of electronic channels and the measurement of Liquid Argon purity are presented. These methods have first been set-up and applied to the experimental data collected in a small TPC located in the Legnaro National Laboratory. Later, they have been modified for the application to the ICARUS T600 detector. Finally, simulated electron and pi0 events have been considered, in order to study algorithms for the separation of signals from these two particles, by measuring the energy loss in the initial region of electromagnetic showers.
ICARUS T600 è un rivelatore di grande massa ed elevata risoluzione dedicato allo studio sperimentale dei neutrini (cosmici e da fascio CNGS), della stabilità della materia e più in generale degli eventi rari. Le caratteristiche più importanti di questo rivelatore sono l'elevata risoluzione geometrica, paragonabile a quella di una camera a bolle, insieme con la possibilità di misura dell'energia depositata. Queste proprietà sono ottenute con un rivelatore elettronico che utilizza un mezzo omogeneo e di grande massa. La ridondanza delle informazioni e la possibilità di identificazione delle particelle lo rendono un rivelatore ideale in particolare per lo studio dei neutrini e consentono l'identificazione del tipo di neutrino interagente. Le interazioni di nutau possono essere riconosciute con selezioni cinematiche a la NOMAD, mentre le proprietà di identificazione delle particelle consentono di distinguere con elevata efficienza e contaminazioni trascurabili i nue CC dalle interazioni di corrente neutra del numu a partire dalla identificazione di elettroni associati al vertice primario. A questo scopo sono stati studiati metodi adatti a distinguere questi due tipi di interazione a partire dalla discriminazione del segnale prodotto da un elettrone e da un pione neutro. Per ottenere questa separazione è importante in primo luogo ricostruire bene l'energia e pertanto è necessario ottenere una precisa calibrazione dei canali dell'elettronica di acquisizione insieme a una misura altrettanto precisa della vita media degli elettroni in Argon Liquido. In questa tesi saranno descritti i metodi messi a punto sia per la calibrazione dei canali dell'elettronica, sia per la misura della purezza in Argon Liquido. Tali metodi sono stati in primo luogo sviluppati a partire dai dati sperimentali raccolti tramite una mini TPC situata presso i Laboratori Nazionali di Legnaro. Successivamente sono stati generalizzati in modo da essere applicati al rivelatore ICARUS T600 nella sua collocazione ai LNGS. Infine si sono analizzati eventi simulati di elettrone e pione neutro per studiare metodi di separazione fra i segnali prodotti da queste due particelle a partire dalla misura vicino al vertice di interazione ed in particolare dallo studio della perdita di energia all'inizio degli sciami elettromagnetici

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Costa, Raimundo Nonato Pereira da. "Polimorfismo dos genes PSGL-1, ICAM1, CD18, mieloperoxidade e manifestações clinicas na anemia falciforme". [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316739.

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Orientador: Fernando Ferreira Costa
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-04T02:23:30Z (GMT). No. of bitstreams: 1 Costa_RaimundoNonatoPereirada_M.pdf: 3164333 bytes, checksum: 78a508da9ba2db4ac569d31a75b1ec47 (MD5) Previous issue date: 2004
Resumo: Anemia falciforme (AF) é uma doença monogênica, mas com uma apresentação clínica variável, devido a possível associação com outros genes. Especula-se que nesta doença genes envolvidos com a resposta inflamatória tenham efeito epistático. A mieloperoxidase (MPO) é uma enzima com atividade antimicrobicida, sendo encontrada nos grânulos azurofilicos dos neutrófilos. O polimorfismo A-463MPO diminui a expressão desta enzima, podendo este alelo ser possível marcador para eventos infecciosos em pacientes com defesa imune já comprometida. Neste estudo 97 pacientes com AF acompanhado pelo ambulatório de hematologia-Unicamp foram inicialmente divididos em dois grupos, conforme o número de internamentos hospitalares para antibioticoterapia: pacientes que não apresentaram infecção com necessidade de intemação (64 pacientes) e um segundo grupo onde ocorreu pelo menos 1 episódio de hospitalização devido a infecção (33 pacientes). O grupo controle foi composto por 48 indivíduos sadios negros da Babia-BrasiL Pacientes e controles foram genotipados para o polimorfismo G/A-463MPO, através da técnica de "Conformation Sensitive Gel Eletrophoresis" (CSGE) e sequenciamento automatizado. Observou-se que a presença do genótipo AA ou AG está associado a maior número de eventos infecciosos (P=O.005 OR=3.8). Esta correlação também foi observada na análise quanto à presença do alelo A-463MPO (P=0.004 OR=2.7). Este achado sugere que deficiência de MPO em pacientes com AF provavelmente favorece a ocorrência de eventos infecciosos. Vaso oclusão é o principal evento nas crises dolorosas dos pacientes com anemia falciforme (AF) e marcadores genéticos de risco para eventos vaso oclusivos ainda são desconhecidos. Polimorfismos em genes envolvidos na adesão celular PSGL-l (VNTR no exon 2), ICAM-1 G241R e K461E) e CD18 (V441V) foram genotipados em 103 pacientes com AF. Os pacientes foram inicialmente divididos em dois grupos: pacientes em que ocorre acidente vascular cerebral (AF+A VC,16 pacientes) e pacientes sem ocorrência de A VC (AF-A VC, 87 pacientes). Posteriormente, os pacientes foram divididos em outros dois grupos: pacientes em que foi detectado um dos seguintes eventos: A VC, síndrome torácica aguda (STA), necrose asséptica de cólo de fêmur (NACF) e priapismo (AF+FVO, 35 pacientes) e pacientes em que não ocorrem essas complicações (AF-FVO, 70 pacientes). PSGL-l é um receptor nas células mielóides e linfócitos T estimulados de alta afinidade para P-selectinas, tendo fundamental papel na adesão dos leucócitos às plaquetas e ao endotélio. O gene contém 3 variantes alélicas (A, B, C) de um número variável de repetição "in tandem" (VNTR). A análise das freqüências dos genótipos e alelos revelou associação da variante B com o grupo AF+FVO [p=O.04, IC 95% OR=2 (1-4)] e quase significante com os casos de A VC [p=0.09, IC 95% OR=2 (0.8-4.9)], enquanto que o alelo A revelou nível significativo de associação com o grupo AF+FVO [p=O.Ol IC 95% OR=O.5 (0.2 0.9)]. O gene da molécula de adesão leucócitário CD-I8 é a beta-2 subunidade das integrinas a_heterodímeros. O polimorfismo C1323T foi recentemente implicado como fator de risco para fenômenos vaso oc1usivos. O estudo deste polimorfismo em pacientes portadores de anemia falciforme não revelou associação significativa com FVO ou A VC. ICAM-l é uma molécula da superfamília das imunoglobulinas com importante papel na adesão das células endotelial-leucócitos durante a resposta inflamatória. No mínimo dois sítios polimórficos são conhecidos R241E e K469E. Ambos sítios estão envolvidos na ligação aos contrareceptores Mac-I e LF A-I. A análise destes polimorfismos através da técnica de CSGE e seqüenciamento, revelou uma associação significativa do heterozigoto K469E para risco a A VC [P=0.02 IC 95% OR=3.6 (1.1-12.3)]. No entanto, o estudo falhou em demonstrar associação alélica com os casos de A VC ou FVO. Como não se conhece bem a relação funcional deste polimorfismo, maiores estudos são necessários incluindo análise funcional, para se esclarecer o real papel deste polimorfismo ao risco a AVC
Abstract: Not informed
Mestrado
Genetica Medica
Mestre em Genética e Biologia Molecular

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31

Knüttel, Helge. "Flavonoidinduzierte phänotypische Plastizität in der Flügelfärbung des Bläulings Polyommatus icarus (Lepidoptera: Lycaenidae) und ihre Bedeutung für Partnerwahl und Arterkennung". [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968874231.

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32

Drexler, Ivy Lea Cormier. "A Passive Membrane Photobioreactor for the Isolated Cultivation of Algal Resource Utilizing Selectivity (ICARUS), with Wastewater as a Feedstock". Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5414.

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Renewed momentum in the microalgae industry due to commercial interest in biofuels and bioproducts is driving the need to increase the economic competitiveness of large-scale microalgal production. Current knowledge of membrane systems common in other disciplines, such as environmental engineering, marine science, and biomedicine, are relevant to algae production. With pore sizes ranging from microns to angstroms, membranes provide tailored functions for solid/liquid separation (cell retention, biomass concentration and dewatering), gas/liquid separation (gas delivery and removal), and solute/liquid separation (bioproduct recovery, feedstock preparation and effluent recycling) that are problematic or not possible with other technologies. Though membranes have great potential to facilitate cultivation and harvesting, challenges in energy reduction and fouling mitigation need to be overcome for long-term, cost-effective applications. This body of research includes a thorough literature review of membrane applications in the algal industry and three experimental studies investigating ways to improve the cultivation and harvesting of microalgal species in wastewater. The first study investigated the growth of native and augmented algal communities in various growth media. Algal monocultures (Chlorella sorokiniana and Botryococcus braunii) and algal communities native to clarifiers of a wastewater treatment plant were batch cultivated in 1) clarified effluent following a BOD removal reactor (PBCE), 2) clarified effluent following a nitrification reactor (PNCE), and 3) a reference medium (RM). After 12 days, all algal species achieved nitrogen removal between 68-82% in PBCE and 37-99% in PNCE, and phosphorus removal between 91-100% in PBCE and 60-100% in PNCE. The pH of the wastewater samples increased above 9.8 after cultivation of each species, which likely aided ammonia volatilization and phosphorous adsorption. Both monocultures grew readily with wastewater as a feedstock, but B. braunii experienced significant crowding from endemic fauna. In most cases, native algal species' nutrient removal efficiency was competitive with augmented algal monocultures, and in some cases achieved a higher biomass yield, demonstrating the potential to utilize native species for nutrient polishing and algal biomass production. In the second study, the isolated cultivation of algal resource utilizing selectivity (ICARUS) process was conceived and developed. ICARUS integrates a passive membrane photobioreactor configuration with wastewater as a growth medium. Eleven membranes of varying porosity and materials were examined based on characteristics and resulting algae productivity. Four ICARUS series (40kDa-PVDF, 0.53 g L-1, 14.1 mg; 0.1µm-PVDF, 0.43 g L-1, 16.6 mg; 12kDa-RC, 0.35 g L-1, 14.5 mg; 0.2 µm-CA, 0.41 g L-1, 14.5 mg) had a final cell density and mass yield that was significantly higher than that of suspended culture (0.25 g L-1, 9.1 mg). Optimal pore size range was identified to be 50-1000 kDa. Six additional series (0.2µm-CA, 0.1µm-PVDF, 40kDa-PVDF, 12kDa-RC, 3.5kDa-PVDF, and 3kDa-RC) also sustained significantly longer exponential growth phases than the suspended cultures. The ICARUS series maintained an average pH of 9.55, which was significantly lower than the average pH of 10.21in the suspended culture. Membrane characteristics affecting the variability in microalgae productivity were evaluated in 2D and generalized linear models. In the third study, select membranes from the laboratory experiments in Chapter 5 (12kDa-RC, 40kDa-PVDF, 7µm-NY) were tested in extended field conditions at a wastewater treatment plant, where the movement of dissolved constituents and biomass productivity were compared to that of closed suspended series. All ICARUS series had higher biomass productivity (RC, 2.87 g L-1; PVDF, 10.6 g L-1; NY, 8.45 g L-1) than the suspended series (0.38 g L-1), which was due to both a longer exponential growth phase and passive dewatering in the ICARUS series. Dissolved ions passed readily across each membrane, and no nutrient limitation was apparent in any series. Gas exchange was slower than expected, which may have been due to external and internal attached growth utilizing gases at the membrane surface. However, dissolved oxygen concentration did not limit algal growth, and adequate carbon dioxide was available to regulate ICARUS pH. In fact, the ICARUS series maintained an average pH of 7.6, whereas the pH of the control series reached 9.8-10.5. The invasion of endemic wastewater species was dependent on pore size; the RC and PVDF series maintained a monoculture, but the NY series had severe contamination. The resulting research has demonstrated a proof-of-concept of a new microalgal cultivation method which may reduce the cost of large-scale cultivation efforts integrated at wastewater treatment plants or within existing algal production facilities. Investigating various wastewater effluents, membranes, and algal strains has allowed for recommendations for the operation of scaled-up systems. Future research should focus on mechanisms and characteristics of biofouling as well as the operation of a field scale prototype. By improving large scale algal cultivation, algal biofuels may become more economically competitive with fossil fuels or other renewables, enhancing their participation in the country's diverse energy portfolio.

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SPANU, MAURA NINUCCIA. "Study on the TPB as wavelength shifter for the ICARUS T600 light detection system in the Fermilab SBN program". Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1220627.

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Frausto, Bernal Paul Axayacatl. "ICARE-S2 : Infrastructure de confiance sur des architectures de réseaux pour les services de signature évoluée". Phd thesis, Télécom ParisTech, 2004. http://pastel.archives-ouvertes.fr/pastel-00000924.

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Actuellement, de plus en plus d'ordinateurs sont interconnectés à l'Internet ou à des réseaux locaux. Il est donc indispensable de partager et de protéger l'information de façon performante. Pour accélérer et favoriser le développement de nouvelles applications et services autour des transactions électroniques, la sécurité devient une priorité. L'infrastructure de gestion de clés (IGC) est une réponse conçue pour assurer la sécurité des transactions électroniques et permettre l'échange de renseignements sensibles entre des parties qui n'ont pas établi au préalable de liens. La signature électronique est un service de base des IGC qui permet l'authentification, la confidentialité, l'intégrité et la non-répudiation de la transaction électronique. Elle devient une composante fondamentale des transactions sécurisées. Elle pourra bientôt se substituer légalement à la signature écrite. Dans ce contexte, notre objectif est de contribuer au développement et à la création de nouveaux e-services nécessaires à la croissance des transactions électroniques: la certification de rôles associés à la signature (pour connaître les privilèges du signataire aux moyens de la définition d'un rôle), l'habilitation et la délégation de signature (pour que quelqu'un puisse donner l'autorisation à quelqu'un d'autre d'exercer un pouvoir à sa place et donner l'autorisation de transférer ce pouvoir à un tiers), la signature électronique contrôlée (pour indiquer qui peut signer un document et contrôler la séquence et les priorités des signatures) et enfin les métadonnées de droits d'accès (pour définir les droits d'accès à un document indépendamment du système d'exploitation utilisé). Une infrastructure de confiance est nécessaire pour prendre en compte ces e-services. Nous proposons l'infrastructure ICARE-S2 (Infrastructure de Confiance sur des Architectures de RésEaux pour les Services de Signature évoluée ) basée sur les principes associés à l'infrastructure de gestion de privilèges et l'infrastructure de gestion de clés, un certificat d'attribut encodé en XML supporté par cette architecture, ainsi que la spécification de ces différents e-services utilisant ce type de certificat. Concrètement, l'infrastructure ICARE-S2 propose un système couvrant les principales fonctions de sécurité nécessaires à un processus transactionnel. De l'authentification et la gestion des droits des utilisateurs et des composants, en passant par le chiffrement des informations, et la gestion de l'intégrité des messages par le biais de certificats électroniques. Une partie de ces travaux a été financée par le projet RNRT ICARE.

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Frausto, Bernal Paul Axayacatl. "ICARE-S2 : infrastructure de confiance sur des architectures de réseaux pour les services de signature évoluée /". Paris : École nationale supérieure des télécommunications, 2004. http://catalogue.bnf.fr/ark:/12148/cb399352534.

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36

Antonello, Annarosa <1967&gt. "Nei cieli di Icaro l'opera va al nero: immaginazione e sentimento per una società post-tecnologica". Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/8409.

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Problema tematico: la società tecnologica ha offuscato, dimenticandole, le figure fonti d’ispirazione e potenza creativa: l’arte in particolare si è separata dalla sua funzione sociale specializzandosi in design e marketing, futili strumenti al servizio del consumismo. Soluzione proposta: L’arte deve tornare a farsi voce critica del presente e simbolo di futuro; forgiarsi una nuova identità autentica attraverso una metamorfosi che rievochi, recuperandolo, il legame con le origini; farsi promotrice di nuovi linguaggi nella direzione di intercettare le evoluzioni antropologiche e comportamentali prodotte dalla deriva tecnocratica in particolar modo del prodotto-uomo digital-virtuale. L’uomo dell’età tecnologica vive due livelli di realtà spesso inconciliabili: nessuno di questi due mondi ha conservato o previsto un pezzetto di cielo per poter ancora volare.

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37

Schnidrig-Petrig, Reinhard. "Modern Icarus in wildlife habitat : effects of paragliding on behaviour, habitat use and body condition of chamois (Rupicapra r. rupicapra) /". [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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38

Sardella, Alessia <1992&gt. "A Feminist Countergenealogy of Black Female Subjects in Europe - An Analysis of Helen Oyeyemi's works 'Gingerbread' and 'The Icarus Girl'". Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/20647.

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Feminism has proved to be a resourceful source in the critique of the discourse of ‘identity politics’, which led to much debate. Similarly, blackness has always been a contested ground calling for a unifying definition. This work will analyze two of Helen Oyeyemi's works, 'The Icarus Girl' and 'Gingerbread', focusing on their young black female protagonists, Jess and Perdita, as much as on the mother of the latter, Harriet, the other co-protagonist of the novel. Foregrounding Europe and Britain as the common sociocultural backgrounds, this work will draw ideas and theories around the topics of blackness and female subjectivities and identities from several fields, such as black feminism. Both the two young characters prove how much convoluted could be to define oneself today – being a young black girl born and raised in Europe - grading it against certain fixed social, cultural and historical frames. Their journey unfolds along the themes of diaspora, return and mother and daughter nexus. As a result, this Master thesis remarks that identity has always been but a slippery terrain, on which power has been constructed in terms of structural, vertical relationships. Consequently, this work considers the examined novels as a direct result of the latter statement and as attempts of subversion in drawing new models of black female subjectivities, as much as contributions towards a black European feminist genealogy, carving out spaces for creativity and criticism for this project.

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39

Guida, Florence. "Rôle de l'exposition professionnelle aux laines minérales dans les cancer broncho-pulmonaires : analyse de l'étude cas- témoins icare". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00785982.

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Les expositions professionnelles représentent la 2nde étiologie de cancer du poumon. Parmi elles, les laines minérales (LM) utilisées comme substitut à l'amiante sont suspectées d'augmenter le risque de cancer du poumon en raison de leur structure proche de celle de l'amiante. Dans ce contexte, ce travail a pour objectif d'évaluer le rôle de l'histoire professionnelle et en particulier celui de l'exposition professionnelle aux LM dans la survenue de cancer du poumon en tenant compte des expositions à l'amiante, à la silice, autres substances très prévalentes dans le secteur de la construction. Une dernière partie a consisté à étudier le risque de cancer du poumon associé à l'exposition professionnelle aux poussières de ciment.Nous avons analysés les histoires professionnelles complètes des cas et témoins inclus dans l'étude cas-témoins en population générale ICARE, identifiés dans 10 départements français abritant un registre général de cancer. Au total, 2 276 cas de cancer du poumon chez les hommes et 2 780 témoins ont été inclus ainsi que 650 cas de cancers du poumon féminins et 775 témoins. Deux stratégies d'évaluation des expositions aux LM et à l'amiante ont été utilisées: une matrice emplois-expositions (MEE) et une matrice tâche-exposition élaborée par des hygiénistes industriels et tenant compte des données individuelles. Les expositions à la silice et au ciment ont toujours été évaluées par MEE. Nos résultats confirment le rôle important des expositions professionnelles comme déterminant du risque de cancer du poumon en mettant en évidence des associations avec de nombreuses professions et secteurs d'activité. L'hypothèse d'une association entre le risque de cancer du poumon et l'exposition professionnelle aux LM est suggérée sans toutefois pouvoir exclure une confusion résiduelle par l'amiante car ces deux expositions sont très corrélées. Par ailleurs, nos résultats confirment le rôle cancérogène de l'amiante et de la silice et suggèrent une association entre l'exposition aux poussières de ciment et le risque de cancer du poumon.

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40

Guida, Florence. "Rôle de l’exposition professionnelle aux laines minérales dans les cancer broncho-pulmonaires : analyse de l’étude cas-témoins icare". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T096/document.

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Les expositions professionnelles représentent la 2nde étiologie de cancer du poumon. Parmi elles, les laines minérales (LM) utilisées comme substitut à l’amiante sont suspectées d’augmenter le risque de cancer du poumon en raison de leur structure proche de celle de l’amiante. Dans ce contexte, ce travail a pour objectif d'évaluer le rôle de l'histoire professionnelle et en particulier celui de l'exposition professionnelle aux LM dans la survenue de cancer du poumon en tenant compte des expositions à l'amiante, à la silice, autres substances très prévalentes dans le secteur de la construction. Une dernière partie a consisté à étudier le risque de cancer du poumon associé à l'exposition professionnelle aux poussières de ciment.Nous avons analysés les histoires professionnelles complètes des cas et témoins inclus dans l'étude cas-témoins en population générale ICARE, identifiés dans 10 départements français abritant un registre général de cancer. Au total, 2 276 cas de cancer du poumon chez les hommes et 2 780 témoins ont été inclus ainsi que 650 cas de cancers du poumon féminins et 775 témoins. Deux stratégies d'évaluation des expositions aux LM et à l'amiante ont été utilisées: une matrice emplois-expositions (MEE) et une matrice tâche-exposition élaborée par des hygiénistes industriels et tenant compte des données individuelles. Les expositions à la silice et au ciment ont toujours été évaluées par MEE. Nos résultats confirment le rôle important des expositions professionnelles comme déterminant du risque de cancer du poumon en mettant en évidence des associations avec de nombreuses professions et secteurs d'activité. L'hypothèse d'une association entre le risque de cancer du poumon et l'exposition professionnelle aux LM est suggérée sans toutefois pouvoir exclure une confusion résiduelle par l'amiante car ces deux expositions sont très corrélées. Par ailleurs, nos résultats confirment le rôle cancérogène de l'amiante et de la silice et suggèrent une association entre l'exposition aux poussières de ciment et le risque de cancer du poumon
Occupational exposures are the second main risk factor of lung cancer. Asbestos has progressively been substituted by mineral wools (MW). Because of their similarity in shape with asbestos, they have been suspected of causing cancer of the respiratory system. In this context, the objectives of this work were to assess the role of occupational history in lung cancer risk; to investigate in details lung cancer risk associated with exposure to MW, carefully taking into account occupational exposures to asbestos and crystalline silica, two common potential carcinogenic exposure among construction workers; and to study the risk of lung cancer associated with occupational exposure to cement dusts.We analysed lifetime occupational history of cases and controls included in the ICARE study, a large multi-centre, population-based, case-control study. They were recruited in 10 French départements with a general cancer registry. The study included 6481 subjects (men: 2 276 lung cancer cases and 2 780 controls, women: 650 lung cancer cases and 775 controls). Two strategies of assessment of occupational exposure to MW and asbestos were used: a job-exposure matrix (JEM) and a task-exposure matrix constructed by trained hygienist and taking into account individual information. Occupational exposures to crystalline silica and cement dusts were both assessed using specific JEMs.Our results confirm the important role of occupational exposure as a determinant of lung cancer risk by showing associations between lung cancer risk and several occupations or industries. An association between MW exposure and lung cancer risk is suggested without being able to exclude a potential residual confounding by asbestos since these two exposures are deeply correlated. Our results also confirm asbestos and silica carcinogenicity and suggest an association between cement dusts and lung cancer risk

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41

Guitton, Philippe. "Une méthode de contrôle statistique de la qualité en fabrication continue : Icare (fondements théoriques et mise en oeuvre)". Rouen, 1987. http://www.theses.fr/1987ROUES040.

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Le système Icare, qui prend effet sur une fabrication en cours, dans laquelle sauf cas de dysfonctionnement, les probabilités d'apparition de défauts sont faibles, est de type évolutif; c'est-à-dire que la vérité du contrôle dépend, du nombre de défectueux récemment observés (dans la version Icare avec défectueux) ou du démérite récemment observé qui est fonction des défauts et familles de défauts rencontrés (dans la version Icare avec défauts). Le rythme des tirages des échantillons est caractérisé par les convoluées de lois uniformes sur un même support. Les principaux résultats théoriques concernent les calculs de la fraction inspectée moyenne, de la qualité moyenne après contrôle et des risques fournisseur et client associés. On présente aussi les mises en oeuvre de la méthode, ainsi que les résultats des différentes expérimentations en milieu industriel

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42

Guitton, Philippe. "Une Méthode de contrôle statistique de la qualité en fabrication continue, ICARE fondements théoriques et mise en oeuvre /". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37605680q.

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43

Ben, khedher Soumaya. "Rôle de l'exposition professionnelle aux agents biologiques dans les cancers broncho-pulmonaires : Analyse de l'étude cas-témoins Icare". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS394.

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Contexte : Le cancer du poumon est le cancer le plus associé aux expositions professionnelles. Bien que l’amiante soit sans doute le facteur étiologique professionnel le plus connu, plusieurs éléments suggèrent également l’implication de facteurs modifiables d’origine environnementale ou professionnelle, beaucoup plus rarement étudiés, parmi lesquels les agents biologiques. Si les endotoxines - toxines situées dans la membrane externe des bacilles Gram négatif - sont fréquemment associées à une réduction du risque de cancer du poumon, les infections à papillomavirus humains sont suspectées d’augmenter ce risque. Les résultats des études épidémiologiques sur le sujet sont divergents et sont régulièrement limités par de nombreuses faiblesses méthodologiques incluant entre autres la non prise en compte du tabagisme et de l’exposition à l’amiante.Objectifs : L’objectif de cette thèse est d’étudier le rôle des agents biologiques présents sur les lieux de travail dans la survenue des cancers broncho-pulmonaires. Plus spécifiquement, les objectifs de ce travail sont : (1) d’étudier le rôle de l’exposition professionnelle aux endotoxines sur le risque de cancer du poumon, d’évaluer les aspects de la relation dose-effet ainsi que les interactions possibles avec les antécédents des maladies respiratoires; (2) de s’intéresser plus particulièrement à l’industrie textile, source de fortes expositions aux endotoxines, en étudiant le risque de cancer du poumon associé à l’exposition professionnelle aux poussières textiles ; (3) d’étudier le risque de cancer du poumon dans l’industrie de la viande en testant, notamment l’hypothèse d’une exposition à un agent viral.Population et méthodes : Ce travail s’est appuyé sur les données de l’étude cas-témoins en population générale ICARE. Les cas de cancer du poumon ont été identifiés dans 10 départements français abritant un registre général de cancer. Au total, 2276 cas de cancer du poumon et 2780 témoins hommes ont été inclus ainsi que 650 cas de cancers du poumon et 775 témoins femmes. Les descriptions détaillées de l’histoire professionnelle complète recueillies par des questionnaires standardisés ont permis de coder les professions et les secteurs d’activités de chaque emploi selon les classifications CITP 1968 et NAF 2000.Résultats : Nous avons trouvé une association inverse entre les expositions professionnelles aux endotoxines et le risque de cancer du poumon particulièrement plus marquée chez les travailleurs de l’élevage (tous types) et de la collecte et traitements des déchets. Les odds ratios de cancer du poumon diminuent avec la durée et l’indice cumulé d’exposition aux endotoxines. Nos résultats ne soutiennent pas l'existence d'une forte association entre l'exposition professionnelle aux poussières textiles et le cancer du poumon, néanmoins, ils montrent une diminution significative de 30% du risque de cancer du poumon chez les travailleurs du coton avec OR= 0,7 ; IC 95% [0,5-0,9]. Par ailleurs, nous observons une association positive significative avec le risque de cancer du poumon chez les travailleurs de l’industrie de la viande (OR= 1,46 [1,0-2,1]). Cependant, les antécédents de verrues de la main ne semblent pas avoir d’effet modificateur dans l’association entre le travail dans l’industrie de la viande et le risque de cancer du poumon.Conclusion : Nos résultats soutiennent le rôle important des expositions professionnelles comme déterminants du risque de cancer du poumon. Ils confirment les associations inverses entre les expositions aux endotoxines et le risque de cancer du poumon suggérant fortement l’hypothèse d’un effet anti-tumoral des endotoxines vis-à-vis du poumon. Par ailleurs, ils semblent indiquer que le travail dans l’industrie de la viande est une situation d’exposition à risque de cancer du poumon sans toutefois conclure formellement quant à l’implication des infections à papillomavirus humains
Background: Lung cancer is the most common cancer associated with occupational exposures. Although asbestos is the best known occupational etiologic factor, several hypotheses suggest the involvement of some environmental or occupational modifiable factors, much more rarely studied, including biological agents. Endotoxins-toxins being part of the outer membrane of Gram-negative bacilli- are commonly associated with reduced risk of lung cancer, while human papillomavirus infections are suspected of increasing the risk. However, the majority of published studies had small numbers of cases and some methodological issues such as inadequate adjustment for tobacco smoking and occupational exposure to asbestos.Objectives: The aim of the present work is to study the role of biological agents found in the workplace on lung cancer risk and more specifically: (1) to investigate the role of occupational exposure to endotoxins on lung cancer risk, to assess dose-response relationship aspects and possible interactions with history of respiratory disease; (2) to focus on the textile industry, which is a source of high exposure to endotoxins, by examining the risk of lung cancer associated with occupational exposure to textile dust; (3) to study the risk of lung cancer in the meat industry by testing the hypothesis of an exposure to a viral agent.Population and methods: This work was based on a large population-based case-control study, ICARE. Cases and controls were recruited from 10 French departments. Incident cases were identified through French cancer registries. A total of 2,926 lung cancer cases (2,276 men and 650 women) and 3,555 controls (2,780 men and 775 women) were included. Detailed information on lifetime occupation was collected through standardized questionnaires. Jobs and sectors were coded according to the ISCO 1968 and the NAF 2000 classifications.Results: Our results showed an inverse association between exposure to endotoxins and lung cancer risk particularly among livestock (all types) and waste collection and treatment workers. Negative trends were shown with duration and cumulative exposure. Furthermore, our findings do not the existence of strong association between occupational exposure to textile dust and lung cancer. A decreased risk was suggested for distant exposures and for work with cotton fibres (OR = 0.7; 95% CI [0.5-0.9]). On the other hand, we observe a significantly increased risk among meat workers OR = 1.46 [1.1-2.1]). However, the history of hand warts does not seem to have any modifying effect on the association between work in the meat industry and the risk of lung cancer.Conclusion: Our findings support the important role of occupational exposures as a determinant of lung cancer risk. This confirms the inverse associations between endotoxin exposures and the risk of lung cancer strongly suggesting an anti-tumor effect of endotoxins towards the lung. This also seems to indicate that working in the meat industry is a risky situation for lung cancer without, however, formally concluding about the involvement of human papillomavirus infections

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Daba, Sintayehu Debebe. "Genetic Diversity and Genome-Wide Association Mapping of Agronomic, Disease Resistance, and Quality Traits in Barley Accessions from Ethiopia, Icarda, and the U.S". Diss., North Dakota State University, 2015. http://hdl.handle.net/10365/24882.

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Plant breeding is a dynamic process that incorporates new germplasm to introduce genetic variation. Knowledge gained from genetic diversity studies and identification of potentially useful germplasm is critical for efficiently utilizing these new materials for breeding program. Linkage disequilibrium (LD), diversity, and association mapping analyses in barley (Hordeum vulgare L.) were done using a mapping panel that included Ethiopian landraces, and cultivars and breeding lines from the Ethiopian, ICARDA, and NDSU breeding programs. LD decayed within 10 to 20 cM in the mapping panel and large proportions of unlinked loci were found to have large LD estimates, indicating that factors other than linkage contributed to LD. Diversity analyses using phenotypic data and molecular markers indicated that the mapping panel was highly structured according to spike row-type, geographic origin, and breeding history; thus, accounting for population structure and familial relatedness was crucial for association analyses. Comparison of the four models (Na?ve, P, K, and P+K) indicated that the P+K model is the best model for the current mapping panel. The genome-wide association study (GWAS) identified 94 QTL for 14 agronomic and disease resistance traits; and 145 QTL for 11 malt and grain quality traits. Association mapping of agronomic and disease resistance traits identified six photoperiod related loci (Ppd_H1, HvFT4, HvGI, HvFT2, HvCO2, and HvCO1) and one vernalization-related locus (VRN-H1) for days to heading, one semi-dwarf locus (sdw3) for plant height, and four resistance loci (Rrs1, Rrs15, rpt.k and rpt.r). The largest number of QTL for malt and grain quality traits was detected in chromosome 5H, followed by chromosome 7H. QTL for malt and grain quality traits were mapped near the Hor1, Hor2, Upg2, Dor4, Ltp1, Amy1, and Amy2 loci. Several unique QTL were identified in the ICARDA and NDSU accessions, with the NDSU materials having the favorable marker genotypes. These regions could be useful to the Ethiopian breeding program for improving malt quality. The current study indicated that association mapping provided useful tool to identify QTL for several traits simultaneously. Because the QTL had small effect and distributed across the genome, genome selection may be warranted for improving these traits.
Kulumsa Agricultural Research Center
ICARDA
Barley Breeding Program of NDSU

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45

Lepé, Delgado Jaime. "Dictados del astral: de la oralidad del Icaro precolombino ayahuasquero a la escritura femenina del himno del Santo Daime". Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/148612.

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Tesis para optar al grado de Magíster en Estudios de Género y Cultura en América Latina mención Humanidades
El Icaro es una melodía de tradición oral sin data, cantada o silbada por el “chamán” amazónico en sus rituales de sanación psico-física. Paralelamente el Santo Daime, una realigión sincrética, comparte con los pueblos originarios el territorio y el bebedizo de variados nombres en la vastedad de la cuenca, reconocido como Ayahuasca, decocción tradicional usada como sacramento para fines rituales y de culto; fundamento cultural a la vez que conocimiento farmacopeo, usada desde milenios por los vegetalistas, con fines medicinales y sus tecnologías del trance. El Santo Daime inicia su desarrollo en los años 30 en un contexto rural, en el estado de Acre, Amazonía brasileña fronteriza a Perú y Bolivia. Su epicentro social, cultural y es-piritual gravita en torno a la tradición del ayahuasca, bebida enteógena de composición psicoactiva, que soslaya las fronteras geopolíticas de los países que comparten esta ma-nifestación cultural viva, estimada conservadoramente, en un lapso de 3.000 a 5.000 años de uso continuo; durante el cual este saber chamánico se ha desplazado, tanto en comunidades indígenas como mestizas, promulgando identidad y pertenencia. En el Santo Daime se canaliza y prescribe conocimiento por intermedio de himnos de transmisión oral y escrita; directrices, fundamentos religiosos y códigos éticos que cimientan su doctrina, cánticos que asumen características sanadoras similares al Icaro indígena. Estas textualidades sonoras, punto axial de la liturgia daimista y del ritual del psiconauta indígena, son captadas por los adeptos más avezados durante el trance de la bebida sacramental, también en sueños y estados ordinarios de conciencia; representan un patrimonio intangible, lingüístico y espiritual de gran valor para el estudio de las manifestaciones culturales que emanan de este misterioso saber herbolario y espiritual amazónico.

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46

BELLOT, THIERRY. "Etude des mecanismes de reaction entre ions lourds aux energies vivitron a l'aide du multidetecteur de particules chargees icare". Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13231.

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Le multidetecteur de particules chargees icare est un equipement de l'accelerateur vivitron. Ses caracteristiques permettent d'etudier, d'une part, les grandeurs dynamiques qui regissent les mecanismes de reaction entre ions lourds et, d'autre part, la structure des noyaux atomiques auxquels ils donnent naissance. Il se compose de 48 telescopes, dont huit sont principalement dedies a la detection des ions lourds (z40) typiquement emis vers l'avant jusqu'a l'angle d'effleurement. Parmi les 40 autres qui servent a detecter les particules legeres chargees (z3), 16 permettent une detection en region avant ou les particules emises sont plus energetiques. D'autres detecteurs additionnels de icare servent dans des applications particulieres. Ce sont des chambres proportionnelles multifilaires a localisation bidimensionnelle, notamment utilisees pour la detection des fragments de fission et des noyaux lourds de recul, et des telescopes munis de jonctions a localisation monodimensionnelle, pour detecter des ions emis en coincidence a des angles voisins. Icare a ete dote d'une electronique associee (dont des modules en standard vxi), completee d'un systeme d'acquisition afin de collecter sur support magnetique les donnees des experiences. Dans la mise au point de l'ensemble du dispositif, des tests realises sous faisceau ont plus particulierement permis de mettre a l'epreuve puis de valider le hardware et le systeme de transfert de donnees, ainsi que le software d'acquisition. L'utilisation de icare a permis de mesurer les correlations angulaires des particules alpha de pre-equilibre emises sequentiellement a partir des quasi-cibles, en coincidence avec les quasi-projectiles (c,n,o) issus des collisions profondement inelastiques #1#6o(133,4 mev)+#4#8ti. L'allure de ces correlations, qui presentent deux maximums asymetriques en region avant de part et d'autre de la direction de detection des quasi-projectiles, a ete comparee aux predictions du modele du point chaud et interpretee en termes d'une approche theorique semi-classique.

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47

Mattei, Francesca. "Rôle de l'exposition professionnelle aux solvants organiques dans le risque du cancer du poumon : analyse multidimensionnelle de l'étude ICARE". Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS061/document.

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Contexte : Bien que le tabagisme soit de loin le facteur de risque majeur de cancer de poumon, les expositions professionnelles, qui représentent la 2eme étiologie majeure de ces cancers, méritent un intérêt particulier. Peu d'information existe actuellement sur le risque de cancer du poumon associé aux expositions professionnelles aux solvants. Ces substances sont largement utilisées dans différentes industries et certaines professions comme les peintres par exemple, particulièrement exposés aux solvants, sont reconnues à risque de cancer du poumon, sans identification de l'agent cancérogène en cause.Objectifs : L'objectif de mon travail de thèse est l'évaluation du rôle de l'exposition à différents solvants organiques (groupés en solvants chlorés, carburants et solvants pétroliers, solvants oxygénés) sur le risque du cancer du poumon. Dans un premier temps nous avons étudié l'effet de l'exposition professionnelle aux solvants chlorés; ensuite l'analyse a intégré l'exposition aux deux autres familles de solvants, toujours en tenant en compte des principaux facteurs de risque de cancer du poumon, y compris le tabac et l'exposition professionnelle à l'amiante.Population et méthode: Ce travail est basé sur les données d'une large étude de type cas-témoins en population générale, ICARE. Des données détaillées sur l'activité professionnelle vie entière ont été recueillis. Au total, 2,926 cas de cancer de poumon (2,276 hommes et 650 femmes) et 3,555 témoins (2,780 hommes et 775 femmes) ont été inclus. L'exposition aux solvants a été évaluée par des matrices emplois-expositions, élaborés séparément par chaque substance par des hygiénistes industriels. En outre, l'exposition à certains solvants était directement déclarée par les sujets dans le questionnaire. Nous avons d'abord suivi une approche d'analyse statistique classique par régression afin d'étudier le rôle des solvants chlorés. Lors de l'analyse qui intégrait les trois familles des solvants, nous avons suivi une approche méthodologique complexe multidimensionnelle. La méthode bayésienne profil regression nous a permis de contourner les limites de l'analyse classique, dues à la forte multicollinéarité qui existe entre les solvants.Résultats et conclusions: L'analyse focalisée sur les solvants chlorés a suggéré une association entre le cancer du poumon et l'exposition professionnelle au perchloroethylene (PCE), en particulier chez les femmes. En revanche, aucune association avec le risque de cancer du poumon n'a pu être mise en évidence par la seconde analyse intégrant les trois familles de solvants (chlorés, pétroliers et oxygénés). Cependant, parce que nous avons augmenté la spécificité de la définition de l'exposition le PCE n'était pas inclus dans les solvants étudiés, nous empêchant de confirmer ou infirmer l'association mise en évidence précédemment. Bien que les solvants ne soient pas associés au cancer du poumon, nous avons identifié deux groupes de sujets avec un risque de cancer du poumon supérieur à la moyenne. L'un de ces groupes incluait notamment une forte concentration de peintres. Notre analyse ne plaide pas en faveur du rôle des solvants pour expliquer cet excès. Malgré l'absence d'association entre l'exposition aux solvants et le risque de cancer du poumon l'approche Bayésienne utilisée nous a permis d'analyser l'exposition conjointe à un nombre relativement important de substances, ce qui est une situation assez courante en matière d'expositions professionnelles. Notre souhait est maintenant grâce à cette nouvelle méthodologie de nous pencher sur l'étude du rôle des expositions conjointes de substances reconnues cancérigènes pour le poumon comme l'amiante, la poussière de silice et les gaz d'échappement du moteur diesel, toutes trois retrouvés très fréquemment dans l'industrie de la construction par exemple
Context: The principal risk factor for lung cancer is by far tobacco smoke, however occupational exposures deserve a special interest because they are the 2nd main etiology of this cancer. Little information is currently available on the relationship between lung cancer risk and occupational exposure to solvents that are widely used in several industries. Certain jobs such as painters, who are particularly exposed to solvents, are known to be at increased risk of lung cancer, but the causative agent is still unknown or unproven.Objectives: The aim of the present work was the evaluation of the role of occupational exposure to different organic solvents on lung cancer risk. Initially we studied the effect of occupational exposure to chlorinated solvents; then the analysis integrated exposure to two other solvent families, namely fuels and petroleum solvents and oxygenated solvents, always taking into account the main risk factors for lung cancer, including cigarette smoking and occupational exposure to asbestos.Population and methods: This work was based on a large population-based case-control study, ICARE. Detailed data on the lifelong occupation was collected. A total of 2,926 cases of lung cancer (2,276 men and 650 women) and 3,555 controls (2,780 men and 775 women) were included. Exposure to solvents was assessed by job exposure matrices, developed separately for each substance by industrial hygienists. In addition, exposure to certain solvents was directly reported by subjects in the questionnaire. First we followed a classical statistical regression analysis approach to investigate the role of chlorinated solvents. In the analysis that included three families of solvents, we followed a multidimensional complex methodological approach. Bayesian profile regression method enabled us to overcome traditional analysis limits due to high multicollinearity between solvents.Results and conclusions: The analysis focused on chlorinated solvents suggested an association between lung cancer and occupational exposure to perchloroethylene (PCE), especially in women. While, no association with lung cancer risk could be demonstrated in the second analysis, incorporating the three families of solvents (chlorinated, petroleum and oxygenated). However, as we had increased the specificity of exposure definition, PCE was not included in the studied solvents anymore, preventing us from confirming or denying the association suggested above. Although solvents were not associated with lung cancer, we identified two groups of subjects whose risk of lung cancer was higher than the average. In particular, one of these groups included a high concentration of painters, however our analysis does not advocate the role of solvents to explain this excess. Despite the lack of association between solvent exposure and risk of lung cancer, the Bayesian approach allowed us to analyze the effect of joint exposure to a relatively large number of substances, which is a fairly common situation in occupational exposures. Thanks to this innovative method, our intention is now to look at the role of joint exposure to substances recognized as carcinogenic for the lung such as asbestos, silica dust and diesel engine exhaust, that are frequently found for instance in construction industry

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48

Carton, Matthieu. "Facteurs de risque professionnels des cancers des voies aérodigestives supérieures chez les femmes : analyse des données de l’étude Icare". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLV002/document.

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Contexte : Peu d’études ont recherché le rôle des facteurs de risque professionnels dans la survenue des cancers des voies aérodigestives supérieures (VADS). Ces études ont été conduites principalement chez des hommes.Objectif : L’objectif de cette thèse était d’étudier les associations entre les cancers des VADS et les expositions professionnelles chez les femmes.Méthodes : Icare est une étude cas-témoins en population générale incluant 296 cas féminins de cancers épidermoïdes des VADS et 775 femmes témoins. Les historiques de carrières recueillis ont été codés et croisés avec les matrices emplois-expositions du programme Matgéné. Outre les intitulés d’emplois, les expositions à 5 solvants chlorés (chloroforme, chlorure de méthylène, perchloréthylène, trichloréthylène, tétrachlorure de carbone), 5 solvants oxygénés (éthylène glycol, tétrahydrofurane, éther éthylique, cétones, alcools), 5 solvants pétroliers (essences carburants, essences spéciales, gazole, benzène, white-spirit) et à 7 poussières et fibres (amiante, farine, cuir, fibres céramiques réfractaires, ciment, laines minérales, silice) ont été étudiées. Les odds-ratios et leurs intervalles de confiance à 95% ajustés sur l’âge, le département, les consommations de tabac et d’alcool ont été estimés par régressions logistiques non conditionnelles.Résultats :Plusieurs professions et secteurs d’activité associés à un risque élevé de cancer des VADS ont été identifiés. Certaines professions (ouvrières de l’alimentation et des boissons, monteuses en appareillage électrique ou électronique, soudeuses) peuvent être à l’origine d’expositions professionnelles aux solvants, aux métaux, aux fumées de soudage et à diverses poussières. Les analyses par nuisance ont mis en évidence des associations significatives entre le risque de cancer des VADS et l’exposition au perchloréthylène et au au trichloréthylène. Aucune association claire n’est observée avec les solvants pétroliers et oxygénés, certains largement utilisés par les femmes L’exposition aux poussières de farine augmente significativement le risque de cancer des VADS. Une exposition probable à l’amiante est associée à une augmentation modérée et non significative du risque. Les analyses par localisation de cancer (cavité orale, pharynx, larynx), limitées par des effectifs faibles, ne mettent pas en évidence d’association spécifique.Conclusion : Nos résultats suggèrent un rôle des expositions professionnelles au trichloréthylène, au perchloréthylène et aux poussières de farine dans la survenue des cancers des VADS chez les femmes
Background : Few occupational studies have addressed head and neck cancer, and these studies have been predominantly conducted in men. Objective : Our objective was to investigate the associations between head and neck cancer and occupational exposures in women Population and methods : ICARE, a French population-based case–control study, included 296 squamous cell carcinomas of the head and neck (HNSCC) in women and 775 female controls. Lifelong occupational history was collected. Job-exposure matrices were used to assess exposure to five chlorinated solvents (carbon tetrachloride; chloroform; methylene chloride; perchloroethylene; trichloroethylene), 5 petroleum solvents (benzene; special petroleum product; gasoline; white-spirits and other light aromatic mixtures; diesel, fuels and kerosene), 5 oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran) and 7 fibers and dusts (asbestos, flour dust, leather dust, refractory ceramic fibers, cement dust, mineral wools and silica) . An analysis by job title was conducted, and then associations with specific occupational exposures were investigated.Odds ratio (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, age and residence area, were estimated with logistic models. Results : Significantly increased HNSCC risks were found for several jobs and industries. Some of these occupations (food and beverage processors, electrical and electronic equipment assemblers, welders and flame cutters) may entail exposure to agents such as solvents, metals, welding fumes and various dusts. Analyses for specific occupational exposures showed a significantly elevated risk of HNSCC associated with exposure to trichloroethylene and perchloroethylene. There is no clear evidence that petroleum or oxygenated solvents, some of them commonly used by women, are risk factors for HNSCC. Exposure to flour dust increased significantly HNSCC risk. Probable exposure to asbestos was associated with a moderate, non-significant elevation in risk. Analyses by cancer site (oral cavity, pharynx, larynx) were hampered by small numbers and did to reveal any specific association.Conclusion : These findings suggest that occupational exposure to perchloroethylene, trichloroethylene and flour dust may increase the risk of HNSCC in women

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Pervilhac, Loredana. "Facteurs de risque des cancers de la cavité orale : Analyse des données d'un étude cas-témoins en population, l'étude ICARE". Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00821931.

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Le cancer de la cavité orale représente un problème important de santé publique en France où les taux d'incidence sont parmi les plus élevés au monde. Bien qu'une détection précoce soit possible, ces tumeurs sont souvent diagnostiquées à un stade avancé et sont ainsi responsables de plus de 1500 décès par an. L'objectif général est de clarifier le rôle et l'impact des différents facteurs de risque dans la survenue des cancers de la cavité orale en France, notamment d'examiner de façon détaillée le rôle du tabac et de l'alcool par localisation anatomique précise, et d'étudier les associations avec d'autres facteurs de risque potentiels (indice de masse corporelle, antécédents médicaux, antécédents familiaux de cancer, consommations de café et de thé). Ce travail s'appuie sur les données d'une large étude cas-témoins en population générale, l'étude ICARE. Il porte sur un sous-ensemble de ces sujets (772 cas de cancer de la cavité orale et 3555 témoins). Les résultats montrent que le tabac augmente le risque de cancer de la cavité orale même pour des quantités et/ou durées faibles, alors que l'augmentation de risque liée à l'alcool n'est observée que pour de fortes consommations. L'effet conjoint du tabac et de l'alcool est plus que multiplicatif. Les associations avec les consommations d'alcool et de tabac varient selon la sous localisation : les associations les plus fortes sont observées pour le plancher buccal, les plus faibles pour les gencives. L'étude des autres facteurs de risque a mis en évidence : une association inverse entre risque de cancer de la cavité orale et indice de masse corporelle, avec un risque plus faible chez les personnes en surpoids ou obèses ; un risque augmenté lorsqu'un parent du 1er degré a été atteint d'un cancer des voies aéro-digestives supérieures ; un risque élevé chez les personnes présentant des antécédents de candidose buccale ; un risque diminué chez les consommateurs de thé ou de café. A partir de ces premiers résultats, il est envisagé de construire un score prédictif de cancer de la cavité orale permettant d'identifier les sujets à risque élevé sur lesquels cibler préférentiellement les actions de dépistage.

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Kelle, Nicole [Verfasser] y Leticia [Akademischer Betreuer] Oliveira-Ferrer. "Einfluss von ICAM1, ICAM2 und BCAM auf die Metastasierung und die Prognose des Ovarialkarzinoms / Nicole Kelle ; Betreuer: Leticia Oliveira-Ferrer". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1181328934/34.

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