Tesis sobre el tema "Human Liver Stem Cells"
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Chen, Shi. "Cryopreservation of human embryonic stem cells and hepatocytes". Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711665.
Texto completoJennings, Adam Edward. "Control of growth and differentiation of human liver stem cells". Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403607.
Texto completoLAI, FEDERICA. "Immunohystochemical markers of stem/progenitor cells in the fetal human liver". Doctoral thesis, Università degli Studi di Cagliari, 2019. http://hdl.handle.net/11584/260751.
Texto completoHamou, Wissam. "Assessing liver regeneration by human embryonic stem cell-derived hepatocytes". Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066374.
Texto completoFinding new sources for liver transplants is a real issue. The main obstacles to organ transplantation are the shortage of grafts and heavy immunosuppressive treatment for life. The ability to reprogram the patient's cells and grow them gives access to a virtually unlimited amount of transplanted cells, thereby eliminating the need for an organ donor. My doctorate is in two parts: the first is to make liver cells by programming of human stem cells. The second is to transplant those cells in the livers of mice with acute and chronic liver failure to study liver regeneration. The novel parts of this project are to study the first phase of post-integration cell transplantation because this phase is critical in regeneration. Also I would compare liver regeneration by transplanted cells in acute liver failure with chronic liver failure. One week after transplantation, the liver of these mice contained the grafted cells and which are located if they behaved as bona fide liver cells producing a protein, human albumin. Even better: analysis of liver function noted a return to normal function in three days with seven days without transplantation against transplanted cells. These results are very encouraging when the possibility of using cells derived from stem cells for therapeutic purposes
Söderdahl, Therese. "Characterization of biotransformation systems in human cells : focus on stem cells and their progeny /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-206-4/.
Texto completoLiu, Chao. "Identification of liver stem-like cells in human derived intrahepatic biliary epithelial cells in vitro". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967345642.
Texto completoLindton, Bim. "Experimental studies of human fetal liver cells : in regard to in utero hematopoietic stem cell transplantation /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-134-9.
Texto completoMinami, Takahito. "Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold". Kyoto University, 2020. http://hdl.handle.net/2433/253138.
Texto completoWinkler, Sandra, Madlen Hempel, Sandra Brückner, Hans-Michael Tautenhahn, Roland Kaufmann y Bruno Christ. "Identification of pathways in liver repair potentially targeted by secretory proteins from human mesenchymal stem cells". Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-207430.
Texto completoGarg, Abhilok. "In vitro processing of human bone marrow derived mesenchymal stem cells to enhance delivery in liver disease". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4326/.
Texto completoGreuel, Selina [Verfasser]. "Expansion of human induced pluripotent stem cells (hiPSCs) in 3D bioreactors for extracorporeal liver support / Selina Greuel". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1206184132/34.
Texto completoKia, Richard. "Novel approaches using human induced pluripotent stem cells and microRNAs in the development of relevant human hepatocyte models for drug-induced liver injury". Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2010059/.
Texto completoEssaouiba, Amal. "Development of a liver-pancreas in vitro model using microfluidic organ-on-chip technologies". Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2573.
Texto completoDiabetes mellitus (DM) or the so called disease of the century is a life threatening dysfunction that affects the endocrine system. The mechanisms underlying the break in the feedback loop that regulates the metabolism and the consequent diabetes induction are not fully known. Understanding the mechanisms of insulin action is therefore crucial for the further development of effective therapeutic strategies to combat DM. Accordingly, it is imperative to find a robust and reliable model for diabetes research able to overcome the limitations of traditional 2D in vitro cell culture and animal experimentation. The aim of this thesis is to develop a new liver‐pancreas co‐culture model using advanced microphysiological systems (MPs) to tackle more effectively the mechanism involving the hepatic and pancreatic endocrine regulation. This work highlights the power of multi organ‐on‐chip systems that combines the advanced 3D‐cell compartmentalization, microfluidics and induced pluripotent stem cells (iPSC) technology to achieve a high biological complexity and functions that are rarely reproduced by only one of these tissue engineering technologies
Amofah, Eunice. "Bone marrow stem cells in liver disease". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497234.
Texto completoCorbineau, Sébastien. "Génération de progéniteurs hépatiques dérivés de cellules souches : application à l’hypercholestérolémie familiale". Thesis, Paris 11, 2011. http://www.theses.fr/2011PA114821/document.
Texto completoHepatocyte transplantation represents an alternative to liver for the treatment of metabolic diseases including familial hypercholesterolaemia. Embryonic stem cells (ES) and induced pluripotent stem cells (iPS) represent new sources of hepatic cells. We have developed an approach to differentiate human stem cells into hepatic cells and thus we have generated hepatic cells derived from iPS of familial hypercholesterolaemia patients
Harun, Rosliah. "Derivation of trophoblast stem cells from human embryonic stem cells". Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414643.
Texto completoAnilkumar, Thapasimuthu Vijayamma. "The pathobiology of hepatic stem cells (oval cells)". Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244072.
Texto completoHarrison, Sean. "Liver cell types derived from pluripotent stem cells". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/liver-cell-types-derived-from-pluripotent-stem-cells(7f39c3ec-facd-4c06-ab9a-7c171313eb05).html.
Texto completoMa, Kwai-yee Stephanie. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells". Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557534.
Texto completoMa, Kwai-yee Stephanie y 馬桂宜. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557534.
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Al, Echrish Noori H. Jasim. "Liver development and the role of mesenchymal stem cells". Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580160.
Texto completoNoisa, Parinya. "Characterization of neural progenitor/stem cells derived from human embryonic stem cells". Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.
Texto completoAoi, Takashi. "Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells". Kyoto University, 2008. http://hdl.handle.net/2433/124215.
Texto completoRatanasirintrawoot, Sutheera. "Defining markers and mechanisms of human somatic cell reprogramming". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11236.
Texto completoJurczak, Daniel. "Stemness in human embryonic stem cells". Thesis, University of Skövde, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3509.
Texto completoStem cells are cells that have a unique ability to divide for an indefinite period. Additionally, they can give rise to a plethora of specialized cell types. The advent of high-throughput technologies made it possible to investigate gene expression on a large scale. This enabled scientists to perform comprehensive gene profiling studies of stem cells. Several authors have suggested that there might be a common set of genes that control the stemness of stem cells. In this study, we suggest that ”stemness” genes that are related to ”stemness” characteristics show a statistically significant down-regulation between undifferentiated and differentiated cells. For this we have analyzed microarray data from five different cell lines and compared their global expression profiles. Common down-regulated transcripts among those data sets were de- rived by using a well-established gene expression analysis procedure called Significance Analysis of Microarrays. Since all three data sets were provided by Cellartis AB, the derived list of common transcripts was subsequently compared with an external study. Moreover, we also performed a comparison with down-regulated genes derived from mouse embryonic stem cells. This was done to determine if there is a common set of stemness genes even across distinct species. Re- sults were further evaluated using a comprehensive data-set from a study by Skottman et al. (2005). All results where compared uti- lizing using a range of false discovery rate threshold values and the results were subsequently used for gene ontology term enrichment. GO terms where utilized to functionally annotate and classify those embryonic stem cell transcripts, that were found to be common in all data-sets and identify over-represented biological processes related to those genes.
Khan, Amir Ali. "Proteomics analysis of human stem cells". Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493771.
Texto completoOwen-Jones, Catrin Eleri. "Stem cells in human oral epithelium". Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55544/.
Texto completoDianat, Noushin. "Cellules souches pluripotentes humaines et modélisation de maladies hépatiques : l'hypercholestérolémie familiale et les cholangiopathies". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114810.
Texto completoCell therapy can be an alternative to liver transplantation in some cases such as severe metabolic diseases. However, the shortage of organ donors implies the need to find new sources of liver cells such as hepatocytes derived from pluripotent stem cells that can be amplified and differentiated extensively into any cell type. Human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) generated from somatic cells of patients and then differentiated into hepatocytes represent a potential source of transplantable hepatocytes. These cells now make it possible to consider the transplantation of genetically modified autologous hepatocytes as an alternative to liver transplantation for the treatment of genetic diseases of the liver.Familial hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutations in the gene encoding the receptor for Low Density Lipoproteins (LDLR), which is the cause of high blood cholesterol in these patients. Homozygous patients should purify their serum LDL-apheresis on average twice a month starting at a young age to avoid fatal myocardial infarction occurring in childhood.Human hepatocytes differentiated from patient’s induced pluripotent stem cells (iPSCs) allow assessing the feasibility to transplant genetically modified autologous hepatocytes as treatment of familial hypercholesterolemia.During the liver development, hepatocytes and cholangiocytes, the two types of hepatic epithelial cells, derive from bipotent hepatic progenitors (hepatoblasts). Although cholangiocytes, forming intrahepatic bile ducts, represent a small fraction of the total liver cell population (3%), they actively regulate bile composition by secretion and reabsorption of bile acids, a process that is important in cholestatic liver diseases. In the first part of this study we developed an approach to differentiate pluripotent stem cells (hESC and hiPSC) into functional cholangiocytes. These cells could be used for the modeling of genetic biliary diseases. In the second part, we generated FH patient specific iPSCs (HF-iPSC), differentiated them into hepatocytes and tried to correct the disease phenotype by lentiviral introduction of LDLR cDNA cassette in HF-iPSC
Bird, Thomas Graham. "Liver regeneration by hepatic progenitor cells". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5634.
Texto completoBowles, K. M. "Generation of haematopoietic cells from human embryonic stem cells". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596829.
Texto completoLam, Shuk-pik. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085647.
Texto completoLu, Wei-Yu. "Defining the liver repopulating capacities of hepatic progenitor cells". Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17875.
Texto completoJoannides, Alexis. "Neural differentiation of human embryonic stem cells". Thesis, University of Cambridge, 2009. https://www.repository.cam.ac.uk/handle/1810/252121.
Texto completoConneally, Helen Ann. "Genetic modification of human hematopoietic stem cells". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27123.pdf.
Texto completoGötherström, Cecilia. "Characterisation of human fetal mesenchymal stem cells /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-139-3/.
Texto completoRugg-Gunn, Peter. "Epigenetic status of human embryonic stem cells". Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614294.
Texto completoChan, Elcie. "Characterisation of microRNAs in human stem cells". Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5476.
Texto completoZhang, Yingying y 张莹莹. "Functional ion channels in human bone marrow-derived mesenchymal stem cells and human cardiac c-kit+ progenitor cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50567032.
Texto completoDeng, Jie. "Neurogenesis of adult stem cells from the liver and bone marrow". [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009700.
Texto completoTypescript. Title from title page of source document. Document formatted into pages; contains 143 pages. Includes Vita. Includes bibliographical references.
Vitillo, Loriana. "Focal adhesion kinase regulation of human embryonic stem cells". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/focal-adhesion-kinase-regulation-of-human-embryonic-stem-cells(31052725-50a4-4d34-a1eb-018be57986af).html.
Texto completoViebahn, Cornelia Sabine. "Interaction between the immune system and liver progenitor cells". University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0055.
Texto completoKung, Janet Wui Cheung. "Investigating the liver progenitor cell niche in the developing human liver". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25953.
Texto completoLam, Shuk-pik y 林淑碧. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085647.
Texto completoTirnitz-Parker, Janina Elke Eleonore. "Primary culture and immortal cell lines as in vitro models to evaluate the role of TWEAK signalling in hepatic oval cells /". Connect to this title, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0039.
Texto completoGow, Adam George. "Production of canine hepatocyte-like cells from stem cell sources". Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10057.
Texto completoGertow, Karin. "Human embryonic stem cells : a novel model system for early human development /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-749-9/.
Texto completoKardel, Melanie Dawn. "Analysis of hematopoiesis from human pluripotent stem cells". Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33333.
Texto completoEirew, Peter. "Detection and characterization of human mammary stem cells". Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34671.
Texto completoTilgner, Katarzyna. "Derivation of oocytes from human embryonic stem cells". Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512211.
Texto completoAdams, William James. "Human Vascular Endothelium from Induced Pluripotent Stem Cells". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10816.
Texto completoEngineering and Applied Sciences