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Harley-McClaskey, Deborah. "Leadership Impact on Human Resources". Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/4714.
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Gomes, Mariana Lourenço Mocho Fernandes. "Lifestyle impact on human sperm function". Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14848.
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Mestrado em Biologia Molecular e CelularOxidative stress (OS) is believed to be an important cause of male infertility, which accounts for about half of all infertility cases. Reactive species (RS)- induced OS is detrimental to spermatozoa, leading to the damage of many biomolecules, such as lipids, proteins and DNA. Several lifestyle factors, such as alcohol and tobacco consumption, are known to induce OS and have been studied for their negative effects on male reproductive system. The aim of this study was to evaluate the impact of acute lifestyle changes, namely alcohol and tobacco consumption, on semen quality, accessory glands function and oxidative balance of sperm cells. Furthermore, the correlation between the OS parameters analyzed and the basic semen parameters was also assessed. Male students, in reproductive age, who participated in the academic festivities, donated a semen sample at three time points: before and one week and three months after the academic festivities. Basic semen analysis was performed and, subsequently, semen samples were processed. Acessory glands function was evaluated and OS was analyzed through measurement of the total antioxidant capacity of the sperm cells and through determination of the expression of antioxidant enzymes glutathione peroxidase 4 and superoxide dismutase 1. The impact of ROS in spermatozoa was also assessed through the determination of the protein carbonyl and 3-nitrotyrosine groups. The results indicate that a decrease in semen quality, demonstrated by a decrease in progressive motility and neutral α-glucosidase concentration and an increase in tail defects, occurs due to lifestyle alterations. The total antioxidant status of sperm cells and variations in protein oxidation levels are dependent on the alcohol and tobacco consumption. Moreover, some correlations were observed between the studied parameters, which may be useful in a clinical perspective. In conclusion, the lifestyle alterations are responsible for a decrease in semen quality and by an increase in protein modifications, which may consequently lead to a decrease in fertilizing potential.
O stress oxidativo (OS) tem sido considerado uma causa importante da infertilidade masculina, que está envolvida em cerca de metade dos casos de infertilidade. O OS induzido pelas espécies reativas (RS) é prejudicial para os espermatozoides, levando a lesões em várias biomoléculas, como os lípidos, proteínas e DNA. Alterações no estilo de vida, como o consumo excessivo de álcool e tabaco, induzem o OS e têm sido extensivamente estudadas devido aos seus efeitos negativos ao nível do sistema reprodutor masculino. O objetivo deste estudo foi analisar o impacto de alterações agudas no estilo de vida, nomeadamente o consumo de álcool e tabaco, na qualidade seminal, na função das glândulas acessórias e no equilibrio oxidativo dos espermatozoides. Para além disso, outro objetivo deste trabalho foi avaliar a possível relação entre os parâmetros de OS e os parâmetros seminais analisados. Estudantes masculinos, em idade fértil, que participaram nas festividades académicas, doaram uma amostra de sémen em três períodos de tempo: antes e uma semana e três meses após as festividades académicas. A análise básica ao sémen foi realizada e, posteriormente, as amostras foram processadas. A função das glândulas acessórias foi avaliada, assim como determinada a capacidade antioxidante total das células, a expressão das enzimas antioxidantes superóxido dismutase 1 e glutationa peroxidase 4 e a presença de grupos carbonilo e 3-nitrotirosina. Os resultados indicam que uma diminuição na qualidade seminal, demostrada por um decréscimo na motilidade progressiva dos espermatozoides e na concentração de α-glucosidase neutra e um aumento nos defeitos da cauda, ocorre devido a alterações no estilo de vida. A capacidade antioxidante total das células e as variações ao nível da oxidação proteica demonstram também ser dependentes do consumo de alcool e tabaco. Foram também verificadas algumas correlações entre os parâmetros analisados que poderão ser importantes numa perspetiva clínica. Concluindo, alterações no estilo de vida são responsáveis pela diminuição da qualidade seminal e pelo aumento de modificações proteicas, o que pode levar consequentemente a um decréscimo do potencial de fertilização.
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Cruz, Daniel Filipe Soares Pereira da. "Lifestyle impact on human sperm oxidative balance". Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13262.
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Mestrado em Biomedicina MolecularInfertility is a clinical condition that affects about 15% of reproductive-aged couples worldwide. Half of these cases are due to male factors. A large percentage of male infertility cases are idiopathic, however, in the last years the influence of oxidative stress in decreased semen quality has been discussed. The lifestyle, including consumption of alcohol, tobacco, drugs and the alteration in circadian cycle, has been proposed as responsible for the increase of reactive oxygen species (ROS). This increase leads to an alteration of the balance between oxidants and antioxidant defenses present in the organism, causing oxidative stress. High levels of ROS damage biomolecules – DNA, proteins or lipids – present in sperm cells and may lead to the loss of membrane integrity, DNA fragmentation or even to death by apoptosis. The aims of the thesis was to evaluate the influence of acute lifestyle changes on oxidative balance of sperm cells. Therefore, we analyzed the antioxidant capacity of the sperm, as well as the presence of certain antioxidant proteins, by colorimetric techniques and immunoblotting. We also evaluated the effect of ROS by measuring the protein oxidation. The seminal quality was evaluated by performing a routine semen analysis. The results indicate that there is a relationship between the changes in lifestyle and the amount of antioxidants in sperm, and the most reported change involved the protein superoxide dismutase (SOD). It was also demonstrated that the variation in protein oxidation levels is dependent on the consumption of alcohol and nicotine. In this study it was concluded that oxidative balance of sperm cells is affected by lifestyle changes; in turn, oxidative balance changes is then reflected in semen quality.
A infertilidade é um problema clínico que afeta cerca de 15% dos casais em idade fértil. Metade dos casos de infertilidade deve-se a fatores masculinos, sendo que uma grande percentagem tem origem idiopática. Nos últimos anos tem-se discutido a influência do stress oxidativo na diminuição da qualidade seminal. O estilo de vida, nomeadamente o consumo de álcool e tabaco têm sido fatores propostos como responsáveis pelo aumento de espécies reativas de oxigénio (ROS), levando a uma alteração do equilíbrio entre os oxidantes e as defesas antioxidantes presentes no organismo, causando stress oxidativo. Níveis aumentados de ROS danificam as biomoléculas – DNA, proteínas ou lípidos – presentes nos espermatozoides, podendo levar à perda da integridade da membrana, à fragmentação de DNA ou até mesmo à morte por apoptose. Este estudo tem como objetivo avaliar a influência da alteração aguda do estilo de vida no equilíbrio oxidativo dos espermatozoides. Desta forma, foi analisada a capacidade antioxidante dos espermatozoides, bem como a presença de certas proteínas antioxidantes, através de técnicas colorimétricas e de immunoblotting. Foi também avaliado o efeito das ROS através da medição de oxidação proteica. A qualidade seminal foi avaliada através da realização de espermogramas. Os resultados obtidos indicam que existe uma relação entre as alterações do estilo de vida e a quantidade de antioxidantes no espermatozoide, sendo que a alteração mais marcada envolveu a proteína superóxido dismutase (SOD). Foi também detetado uma variação dos níveis de oxidação proteica, dependente da alteração dos consumos de álcool e nicotina. Com este trabalho concluiu-se que o equilíbrio oxidativo dos espermatozoides é afetado pelas alterações no estilo de vida, sendo que a alteração deste equilíbrio reflete-se posteriormente na qualidade seminal.
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Richards, Joseph B. "Impact of the Internet on consumer human capital". Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2002. http://wwwlib.umi.com/cr/syr/main.
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Chu, Suk-ling y 朱淑玲. "Impact of indoor air pathogens on human health". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31253362.
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Dede, Eric O. "The impact of land contamination on human health". Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/76618/.
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Land contamination is an issue of concern in land regeneration and the built environment. To ensure the sustainability of the built environment, it is important that the risk to human health due to land contamination is addressed adequately. Current generic assessment criteria (GAC) values used in the assessment of contaminated land in the United Kingdom (UK) are very conservative. Although this is protective of human health, it may lead to un-necessary and costly remediation of land or result in land being left un-used. This highlights the need for improved understanding of human exposure to soil contaminants, which this work sought to promote. This thesis presents findings from our assessment of human exposure to five toxic elements; arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb) and nickel (Ni), carried out using individuals who grow and consume their allotment produce. The primary exposure pathway investigated was oral ingestion through the consumption of produce. Concentrations of these elements were measured in samples of soil and produce. Site-specific risk assessment carried out using element concentrations and participants’ produce consumption data indicated no significant health risk to the participants. During the risk assessment process, it is necessary that element bioaccessibility values are determined and considered in the assessment to ensure that the risk is not over-estimated. To improve our understanding of actual human exposure to these elements though the oral ingestion pathway, we carried out biomonitoring and produced human physiologically-based kinetic models to assess internal exposure to these elements. Measured concentrations of blood Pb and urinary As, Cd, Cr and Ni were similar to the corresponding levels in the general (nonoccupationally exposed) populations in the UK; indicating that the participants were not exposed to these elements at levels importantly higher than other adults in the UK. In addition, this indicates that participants’ consumption of allotment produce did not result in them having significant additional exposure to the elements. The models, implemented in MATLAB, predicted the literature data and our biomonitoring data well. Because these models are capable of predicting internal exposure to these elements, they improve our understanding of exposure to the elements, which is important in the sustainable management of land contamination. To our knowledge, it is the first time combined biomonitoring and physiologically-based models for the five toxic elements have been used to assess exposure among allotment users.
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Martins, Amadeu Manuel Quelhas. "The impact of cardiac feedback on human cognition". Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1308/.
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Afferent feedback from arterial baroreceptors modulates sensorimotor responses, but it is unknown whether it can also interfere with high-order cognition. In Study One, electrocutaneous stimuli (ranging from non-painful to very painful) were randomly delivered across the cardiac cycle. Pain ratings were highest at R+300 ms, whereas nociceptive reflex responses did not vary. Study Two followed up these findings by presenting the stimuli in blocks of either ascending or descending intensities. Nociceptive responses to painful stimuli were attenuated during systole; pain ratings did not vary regardless of stimulus intensity. Study Three compared both schedules of stimulation independently of cardiac cycle timings. When unpredictable, shocks elicited hypoalgesia but also the highest nociceptive responses, indicating that pain dissociates from nociception under stress. The fourth study examined the effects of moderate exercise-induced cardiovascular arousal on attention control and working memory. Two experiments revealed that working memory and attention are facilitated by moderate exercise. Finally, Study Five assessed Sternberg task performance across the cardiac cycle. Probes presented during systole produced the highest intercept but the shallowest slope. In sum, these studies (a) provide further support for the afferent feedback hypothesis; and (b) extend previous findings obtained with sensorimotor responses to high-order cognition.
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Bunting, M. J. "Environmental history and human impact in Orkney, Scotland". Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/271916.
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Khoruzhii, V. V., Марина Миколаївна Дунаєва, Марина Николаевна Дунаева y Maryna Mykolaivna Dunaieva. "The impact of chronic stress on human health". Thesis, Sumy State University, 2020. https://essuir.sumdu.edu.ua/handle/123456789/77970.
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Most people associate stress with negative feelings. This is the physical and psychological response of the body that helps us better cope with a critical situation. The body releases hormones that speed up the heart rate and bring the muscles into full combat readiness. But chronic stress can have severe consequences. Stress can be caused by everyday worries, problems at work, or an accidental quarrel with relatives. More serious life circumstances, such as a doctor's disappointing diagnosis, war, or the death of a loved one, lead to chronic stress. Stress affects a person's emotions, mood, and behavior. No less important, and often more serious, is its effect on the human body.
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Melnik, Y. y T. Linnik. "Chemtrails impact on the environment and human brains". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/30866.
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Humans have undeniably affected the atmosphere and air quality of our planet. However, because most gasses are invisible to the human eye, it can be hard to physically see some of the changes we've brought about. Smog, exhaust from cars and trucks and smoke from chimneys and fires are a few of the visible signs, but one of the most intriguing visual manifestation of how we've changed the atmosphere are the jet trails left behind by airplanes.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/30866
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Rentzsch, Viola. "Human trafficking 2.0 the impact of new technologies". University of the Western Cape, 2021. http://hdl.handle.net/11394/8353.
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Magister Legum - LLMHuman history is traversed by migration. This manifold global phenomenon has shaped the world to its current state, moving people from one place to another in reaction to the changing world. The autonomous decision to permanently move locations represents only a segment of what is considered to be migration. Routes can be dangerous, reasons can be without any alternative, displacements forced, and journeys deadly. Arguably the most fatal of all long-distance global migration flows, the transatlantic slave trade has left an enduring legacy of economic patterns and persistent pain. Whilst the trade in human beings originated centuries before, with Europe’s long history of slavery, this event represents an atrocious milestone in history. In a nutshell, European colonialists traded slaves for goods from African kings, who had captured them as war prisoners.
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Chu, Suk-ling. "Impact of indoor air pathogens on human health /". Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17457798.
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Atomsa, Nebiyu Tariku <1993>. "The Impact of Climate Change on Human Health". Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21902.
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It is no more news that climate change and variability are greatly impacting our daily lives. Variations in temperature and extreme event trends that we have witnessed in the past decades are consequences of the increase in greenhouse gases concentration, which are subsequently affecting the Human Health. This in turn, certainly affects the quality of life and general well-being of each individual. This paper is intended to evaluate how climate change and variability is affecting, be it directly or indirectly, the human health, the quality of lives and its economic implications. Given the expansive implications climate change carries on human health, it should be regarded of fundamental importance, not only to doctors and health professionals, but also to individuals in any sphere of life, as no one living in this planet is immune to climate change impacts.
Climate change is the greatest pressing threat to human health today, and it must be addressed via a combination of mitigation and adaptation techniques. We can all agree that the current generation has the responsibility and the only chance to reverse the present climate change trend before it is too late for the next one. The global human health effects of climate change are not commonly spoken about as frequently as it should be as it is the cause of many diseases, or at least reason to exacerbate pre-existing conditions. Now, thankfully there is a much greater interest in climate change’s effect on human health, and thanks to a considerable progress in new technologies developed around the world, we are now able to evaluate various climate stressors and their potential health impacts. The issue remains that these impacts have a wide range of repercussion that exacerbate the current and future public health burden as well as socio-economical dimensions.
Sadly, those with the least capacity to adapt to climate change are the ones which are most vulnerable, including people of third world countries and disadvantaged populations such as the poor, racial and ethnic minorities in industrialized countries, creating environmental justice imbalance among different countries and areas. Unfortunately, it’s impossible to definitely attribute the responsibilities of climate change impacts to certain countries, even though it’s globally undisputed that most developed countries have unfairly contributed to the vast emission of greenhouse gases into the atmosphere.
Climate change does not only threaten the physical structure and human health, but it also damages the whole socio-economic structure that is key to maintaining a healthy and stable society. So, what we do today against climate change, is what will define the future wellbeing of our environment. In view of an unavoidable climate change scenario, adequate adaption and aggressive mitigation strategies are the best actions to focus on.
This thesis is mainly focusing on highlighting the major impacts of climate change on human health by identifying the direct, indirect and social effects.
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Oliva, Pavia Meritxell. "Functional impact of polymorphic inversions in the human genome". Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/286269.
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Una inversió és una reordenació genòmica que altera l'orientació d'una seqüència genòmica específica. Les inversions són reordenaments balancejats i no impliquen necessàriament un guany o pèrdua d'ADN, però tot i així poden alterar el contingut genètic original i causar-hi mutacions. A més, les inversions poden modificar els patrons de recombinació d’ADN tan de la seqüència genòmica continguda en la inversió com també en regions flanquejants. Conseqüentment, les inversions poden estar associades a certs fenotips o malalties, influir en l’evolució dels individus portadors a través de processos adaptatius o jugar un paper clau en l’origen de noves espècies. Per tot això, expandir el nostre coneixement de les inversions és clau per a la comprensió en profunditat de la variació del genoma i les seves conseqüències. Tanmateix, la nostra comprensió tan de l’abundància com de l’impacte funcional de les inversions en el genoma humà és escàs, i se sap ben poc sobre la seva associació a canvis d'expressió gènica en aquesta espècie.
Durant els últims 10 anys, l’aparició de noves tecnologies de seqüenciació genòmica ha fet permès l'estudi de les variacions estructurals a gran escala, incloent les inversions. Aprofitant aquesta oportunitat,, el projecte INVFEST ha dedicat esforços en la construcció del catàleg d' inversions polimòrfiques en humans més precís i exhaustiu fins a la data. Per aconseguir-ho,, hem demostrat que GRIAL, l’únic mètode disponible dissenyat específicament per identificar inversions a partir de l’alineament de fragments aparellats (“PEM”), prediu inversions amb més precisió i eficiència que altres mètodes de detecció basats en “PEM”, i sobretot refina molt millor els punts de trencament. A més, les prediccions d’inversió de GRIAL s’han filtrat utilitzant diversos filtres pre i post mapeig, juntament amb la inspecció manual de casos complexos, aconseguint així una reducció de la taxa de falsos positius.
A continuació, per obtenir una major comprensió sobre l'impacte funcional de les inversions polimòrfiques en el genoma humà, hem examinat el solapament de 44 inversions amb gens. En general, els nostres resultats mostren que les inversions tendeixen a estar ubicades en regions intergèniques encara que hem identificat un 13,6% dels casos on les inversions afecten exons de gens. Per tal d’analitzar com les inversions afecten l’expressió gènica, s’han realitzat dos estratègies complementaries. La primera consisteix en un anàlisi d’expressió diferencial en línies cel·lulars limfoblàstiques (“LCLs”) de 527 mostres de poblacions HapMap europees, asiàtiques i africanes. La segona està basada en l’anàlisi de marcadors d’inversió (“tag-SNPs”) associats a canvis en l’expressió de gens en diferent teixits. Conjuntament, hem identificat 19 inversions que modulen l'expressió gènica de 43 gens en múltiples teixits. Aquests resultats semblen coherents, ja que un subconjunt (N = 11) de les associacions trobades en “LCLs” ha estat identificat per ambdós mètodes. En concret, hem identificat una inversió que afecta l'expressió de gens paràlegs codificants de les proteïnes IFITM2 i IFITM3 en limfoblasts. Hem validat també la metodologia emprada per a l'anàlisi d'expressió diferencial reproduint associacions conegudes amb gens de dues inversions àmpliament estudiades (17q21.31, 8p23.1), identificant així noves associacions no descrites entre 17q21.31, 8p23.1 i l'expressió de 6 gens en total. A més, en el cas de 17q21.31, observem que almenys 2 d'aquests gens estan associats a reordenaments estructurals en la regió estudiada. Finalment, hem buscat possibles associacions d’inversions amb malalties, i hem identificat un cas on la inversió sembla estar associada amb esclerosi lateral amiotròfica en dos estudis d’associació genòmica (“GWAS”) diferents.
El coneixement adquirit en aquest estudi contribueix així a una millor comprensió del paper de les inversions polimòrfiques en la regulació de l'expressió gènica i en les conseqüències d'aquest tipus de variant estructural tan poc estudiada en humans.An inversion is a balanced genomic rearrangement that alters the orientation of a specific genomic sequence. Despite not usually causing gain or loss of DNA, inversions can alter the original genetic background and produce mutational and positional effects on genes. In addition, inversions can alter recombination patterns both on the DNA sequences encompassed by them and in their vicinity. Therefore, inversions may associate with certain phenotypes or diseases, shape the evolutionary fate of the carriers by adaptive processes or even play a role in the origin of new species. For all that, increasing our knowledge of inversions constitutes a key issue for in-depth understanding of genome variation and its consequences. However, little is known about the prevalence and functional impact of inversions in the human genome, and in particular of their association with gene expression changes in humans. For the last 10 years, the advent of novel genomic technologies has enabled the study of SVs, including inversions, in a high-throughput fashion within and across species. State of the art genomic research provides the means and tools to explore the human genome in detail and expand our knowledge of inversions. Against this backdrop, the INVFEST project has devoted efforts to build the most accurate and exhaustive catalogue of human polymorphic inversions to date. For that, we have benchmarked GRIAL, currently the only paired-end mapping (PEM) based algorithm specifically designed to predict inversions, and demonstrated that performs with more accuracy and efficiency compared to other PEM based SV-detection methods, particularly in refining inversion BPs. In addition, we have curated GRIAL inversion predictions by using several pre and post PEM mapping filters coupled with manual inspection of complex cases and minimized the rate of false positive predictions. Next, to gain further insight on the functional impact of polymorphic inversions in the human genome, we examined the overlap of 44 different inversions with genes. Overall, our results show that inversions tend to be located in intergenic regions but in 13.6% of the cases gene exons are affected. We performed two complementary approaches to identify inversion associations with gene expression. First, we performed a linear regression analysis in three different expression datasets derived from 527 lymphoblastoid cell lines (LCLs) of European, Asian and African HapMap individuals. Second, we interrogated blood and non-blood tissues by contrasting expression quantitative trait loci (eQTL) data with inversion tag-SNPs. We report 19 inversion rearrangements that modulate gene expression of 43 genes in several tissues. These results seem consistent as a subset (N = 11) of the associations found in LCLs has been identified by both approaches. Interestingly, we have identified an inversion that affects the expression of paralogous protein-coding genes (IFITM2/IFITM3) in lymphocyte-derived cells. We have also validated the methodology used for differential expression analysis by reproducing known effects of two well-studied inversions (17q21.31, 8p23.1) and identified novel associations of both inversion haplotypes with the expression of 6 genes. Moreover, we observe that at least 2 of these genes are associated to 17q21.31 structural rearrangements. Finally, we have looked for possible associations of inversions with disease and found one inversion that seems to be associated with amyotrophic lateral sclerosis in two different GWAS studies. Insight gained in this study could therefore contribute to a better understanding of the role of polymorphic inversions in the regulation of gene expression and the consequences of this understudied type of genetic variants in humans.
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Hughes, Timothy A. "Biomechanical model of the human thorax for impact analysis". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA370880.
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Thesis (M.S. in Mechanical Engineering) Naval Postgraduate School, September 1999."September 1999". Thesis advisor(s): Young W. Kwon. Includes bibliographical references (p. 49-50). Also available online.
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HASSAN, ABDULLAHI NUR y JAMES RAD ANAMAN. "THE IMPACT OF HUMAN RESOURCES MANAGEMENT ON CUSTOMER SATISFACTION". Thesis, Mälardalen University, School of Business, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-6404.
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Grant, Michael James. "The palaeoecology of human impact in the New Forest". Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427406.
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Dodd, R. H. "Examining the psychosocial impact of human papillomavirus oropharyngeal cancer". Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1522414/.
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The causal role of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OSCC) has been well established. The work presented in this thesis sets out to explore the information available about HPV-OSCC and examine the psychosocial issues associated with a diagnosis of HPV-OSCC. Six studies were carried out between 2013 and 2016. Study 1 systematically reviewed the existing literature examining the psychosocial impact of HPV-OSCC in patients (n=10 studies) and current knowledge of the relationship between HPV and OSCC (n=41 studies). Study 2 was a content analysis examining the media coverage in the UK of the link between HPV and OSCC (n=112 articles). Study 3 was a qualitative study with health professionals caring for HNC patients (n=15). Study 4 was an extension of study 3, developing a survey for dissemination among health professionals working with HPV-OSCC patients (n=260). Both studies explored their experiences of and attitudes to discussing HPV with their patients, with study 4 additionally measuring knowledge of HPV-OSCC. Study 5 was a qualitative study with patients diagnosed with HPV-OSCC (n=20) and with some of these patients’ partners (n=12), examining their experiences around the diagnosis of HPV-OSCC. Study 6 involved the development of an information booklet about HPV-OSCC, based on the findings of studies 1-5. The existing literature examining the psychosocial impact of HPV-OSCC provided limited evidence about the impact of HPV in OSCC patients. Knowledge of HPV in OSCC was not well known across most populations, and the HPV-OSCC content presented in the media lacked basic facts about HPV. The increasing incidence of HPV-OSCC was a significant issue for health professionals and key messages to communicate to HPV-OSCC were found. Reactions about HPV were mixed among participants whose cancer or partners’ cancer was caused by HPV. An information booklet developed about HPV-OSCC was well received by patients and health professionals and could act as a discussion tool to provide patients with evidence-based information. De-escalation of treatment in the future may help minimise some of the negative psychosocial outcomes associated with HPV-OSCC and improve long-term functioning.
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Bankole, Felix Olubisi. "Investigating the impact of ICT investments on human development". Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/11873.
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Includes abstract.Includes bibliographical rereneces (leaves 114-128).
In the last two decades, the worldwide information and communication technology (ICT) market has been growing at a rapid rate. This has led to the global net increase in ICT usage and investments. International organizations, ICT vendors, policy makers have been trying to determine if such huge investments are worthwhile. However, the result regarding this issue is inconclusive, for this research area is fraught with complexity and existing empirical study is limited. Investigating the impact of ICT investments on human development requires appropriate methods that can provide a deeper understanding and which are based on IS perspective theory. Of particular importance are different aspects of ICT investments and the components of human development. For example, ICT investments consist of four aspects namely hardware, software, internal spending and telecommunication investments while human development components are GOP, literacy rates and life expectancy rates. If these variables are not modelled correctly, their effect on each other can be either under- or overestimated and the appropriate level of impact is therefore required.
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Zhang, Feng. "Cyanobacterial blooms: causes, innovative monitoring and human health impact". The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405800137.
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Godwin, Donna D. "The Impact of Gender on Domestic Human Rights Abuse". Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4515/.
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This study develops three models of human rights determinants with the inclusion an untested variable, women in parliaments. The research is conducted on pooled cross-sectional time-series data from 130 countries between 1978 and 1996. For the purpose of analysis the Prais-Winsten Regression method with Panel Corrected Standard Errors was used. The women in power variable is hypothesized to be significantly, positively correlated with a state's propensity toward respect for human rights and is operationalized as percentage of women in parliaments. Three models incorporating as control variables previously identified correlates of human rights abuse were utilized to asses the impact of percentages of women in parliaments on two individual subsets of human rights: personal integrity rights and socio-economic rights. Two models were designed to measure the subset of rights categorized as personal integrity rights using two separate measures: State Department Scores and Amnesty International Scores. Model number three utilized the Physical Quality of Life Index to measure levels of socio-economic rights. Statistical significance was demonstrated by the women in parliament variable in all three models.
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Kanda, Tomo. "The Impact of Environmental Factors on Human Physiological Functions". Kyoto University, 2000. http://hdl.handle.net/2433/181025.
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Kyoto University (京都大学)0048
新制・課程博士
博士(人間・環境学)
甲第8460号
人博第90号
11||158(吉田南総合図書館)
新制||人||22(附属図書館)
UT51-2000-F364
京都大学大学院人間・環境学研究科文化・地域環境学専攻
(主査)教授 家森 幸男, 教授 津田 謹輔, 助教授 森谷 敏夫
学位規則第4条第1項該当
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Shorthouse, Edward. "Climate change and buildings : the impact on human health". Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/21077.
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The health risks posed by hot weather are growing as increasingly frequent extreme weather is brought about by climate change. People spend upwards of 80% of time indoors and so human health is largely dependent on the internal environment of buildings. In the building industry engineers currently design buildings for high-energy performance by maximising heat retention, and whilst this may be effective in cold winters, it can lead to unbearable indoor conditions in hot summers. Thermal comfort inside buildings is a well-discussed topic both in industry and academia, but absolute peak thresholds, especially for heat stress still require development. In this thesis the outcomes of research into the effects of current and future hot weather on the heat stress of occupants inside buildings are presented. Hot weather data from the current climate and mortality rates are compared and several temperature metrics are analysed with respect to health risk forecasting performance, so that peak threshold limits for human health indoors are established for the building design industry. Reference weather data used in building simulations for health assessment is currently chosen based on air temperature alone. In this thesis new reference weather data is created for near-extreme and extreme weather and for current and future climates, based on the peak threshold metric research and future weather analysis. By 2050 hot weather reference years currently occurring once every seven years could become an annual occurrence, and by 2080 extreme hot weather reference years currently occurring once in twenty-one years could become an annual occurrence. Computational fluid dynamics is then used to simulate the internal heat stress inside a building model, and a surrogate model is created to emulate heat stress levels for full calendar years of future climates for several UK locations. It is envisaged that the results presented in this thesis will help inform the industry development of new reference data and aid better building design.
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Aida, Toru. "Study of human head impact brain tissue constitutive models /". Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1402.
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Thesis (Ph. D.)--West Virginia University, 2000.Title from document title page. Document formatted into pages; contains x, 133 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 122-130).
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Jackson, Anita Estell. "The Impact of Human Resources on Nurses' Turnover Intention". ScholarWorks, 2020. https://scholarworks.waldenu.edu/dissertations/7932.
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Nurse retention is of great concern to healthcare organizations including hospitals. With so many countries reporting a shortage in nursing personnel, healthcare organizations are now seeking ways to reduce this shortage. It is known that job satisfaction and turnover intention impact nurses' continued employment. However, the role of human resources (HR) impact on nurses' job satisfaction and turnover intention is unknown. The theoretical basis of this study came from the work of Bowen and Ostroff who argued the strength of HRM system regulates employee perceptions and outcomes within an organization. Therefore, the purpose of this study was to evaluate the impact HR service quality had on registered nurses' turnover intentions mediated by job satisfaction and moderated by gender, in a hospital setting within the state of Maryland. Data was collected from 83 registered nurses licensed in Maryland. A multiple regression analysis of data collected from HR service quality measures of responsiveness, reliability, and empathy in addition to gender, job satisfaction, and turnover intention revealed statistically nonsignificant results involving nurses' perceptions of HR service quality predicting turnover intention. Job satisfaction failed to mediate the relationship between HR service quality indicators and turnover intention, and gender failed to moderate the relationship between HR service quality indicators and turnover intention. Although the research revealed statistically nonsignificant findings, it adds to the body of literature regarding the topic of HR service quality. This study has social change implications by informing healthcare organizations about the significant role of HR service quality indicators and its impact on nursing job satisfaction and turnover intention.
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Grudina, Clara. "The impact of FOXG1 on human cortico-cerebral astrogenesis". Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4856.
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Foxg1 is a transcription factor gene involved in key steps of early
corticocerebral development, including specification of the telencephalic and
cortical fields, tuning of proliferation/differentiation kinetics, radial migration of
projection neurons and laminar specification of them. Its allele dosage is
crucial. Hemizygosity for Foxg1 and duplication of it result into two
devastating nosological entities, namely the Rett and West syndromes,
respectively. We previously showed that Foxg1, like its Drosophila m. ortholog
sloppy paired, also antagonizes gliogenesis.
Aim of this study was to investigate the role of FOXG1 in human cortex, in
particular the early commitment of pallial precursor cells towards glial fates
and subsequent implementation of the astrocytic differentiation program.
For this purpose, we followed two approaches: (1) we modulated the
expression of Foxg1 by lentiviral vectors in human pallial precursor cells
originating from the embryonic W8 of the gene in early commitment and
astrocytic differentiation; (2) we generated human induced pluripotent stem
cells (hiPSCs) starting from somatic non neural cells of patients affected by
the FOXG1 linked variant of the WS, then we forced these iPSCs to
differentiate to cortical precursors to score their histogenetic properties.
We found that Foxg1 overexpression in pallial precursor cells reduces their
astroglial output, in particular S100β+population. An opposite effect is elicited
by halving Foxg1 gene dosage. Moreover Foxg1 overexpression also
interferes with selected aspects of late astrocyte differentiation, possibly
jeopardizing anti-excitotoxic capability of these cells.
These findings may help to reconstruct the molecular logic underlying normal
articulation of astrogenesis. Moreover they provide useful hints about
pathogenetic mechanisms leading to neurological disorders triggered by
altered FOXG1 dosage.
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Verma, Khyati. "Characterization of human heart and lung under dynamic impact". Thesis, IIT Delhi, 2018. http://eprint.iitd.ac.in:80//handle/2074/8035.
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Panzer, Matthew. "Numerical Modelling of the Human Cervical Spine in Frontal Impact". Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2865.
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Motor vehicle accidents continue to be a leading cause of cervical spine injury despite a conscientious effort to improve occupant safety. Accurately predicting occupant head and neck response in numerical crash simulations is an essential part of the process for developing better safety solutions. A biofidelic model of the human cervical spine was developed with a focus on accurate representation of the cervical spine at the local tissue level. These tissues were assembled to create a single segment model that was representative of in vitro spine in quasi-static loading. Finally, the single segment models were assembled to create a full cervical spine model that was simulated in dynamic loading and compared to human volunteer response.
Models of each segment were constructed from the basic building blocks of the cervical spine: the intervertebral disc, the vertebrae, the ligaments, and the facet joints. Each model was simulated in all modes of loading and at different levels of load. The results of the study indicate that the cervical spine segments performed very well in flexion, compression, and tension. Segment response to lateral bending and axial rotation was also good, while response in extension often proved too compliant compared to the experimental data. Furthermore, the single segment models did not fully agree with the experimental shear response, again being more compliant.
The full cervical spine model was assembled from the single segment models incorporating neck musculature. The model was simulated dynamically using a 15 G frontal impact test. Active muscles were used to simulate the response of the human volunteers used in the study. The response of the model was in reasonable agreement with the experimental data, and compared better than current finite element cervical spine models. Higher frequency oscillation caused most of the disagreement between the model and the experimental data, which was attributed to a lack of appropriate dynamic material properties of the soft tissues of the spine. In addition, a study into the active properties of muscle indicated that muscle response has a significant influence on the response of the head.
A number of recommendations were proposed that would improve the biofidelity of the model. Furthermore, it was recommended that the future goal of this model would be to implement injury-predicting capabilities through the development of advance material models.
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Afshan, Sheeva. "Search-based generation of human readable test data and its impact on human oracle costs". Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4337/.
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The frequent non-availability of an automated oracle makes software testing a tedious manual task which involves the expensive performance of a human oracle. Despite this, the literature concerning the automated test data generation has mainly focused on the achievement of structural code coverage, without simultaneously considering the reduction of human oracle cost. One source of human oracle cost is the unreadability of machine-generated test inputs, which can result in test scenarios that are hard to comprehend and time-consuming to verify. This is particularly apparent for string inputs consisting of arbitrary sequences of characters that are dissimilar to values a human tester would normally generate. The key objectives of this research is to investigate the impact of a seeded search-based test data generation approach on test data oracle costs, and to propose a novel technique that can generate human readable test inputs for string data types. The first contribution of this thesis is the result of an empirical study in which human subjects are invited to manually evaluate test inputs generated using the seeded and unseeded search-based approaches for 14 open source case studies. For 9 of the case studies, the human manual evaluation was significantly less time-consuming for inputs produced using the seeded approach, while the accuracy of test input evaluation was also significantly improved in 2 cases. The second contribution is the introduction of a novel technique in which a natural language model is incorporated into the search-based process with the aim of improving the human readability of generated strings. A human study is performed in which test inputs generated using the technique for 17 open source case studies are evaluated manually by human subjects. For 10 of the case studies, the human manual evaluation was significantly less time consuming for inputs produced using the language model. In addition, the results revealed that accuracy of test input evaluation was also significantly enhanced for 3 of the case studies.
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Singh, Neelam. "A Study of Human Impact on Sacred Groves in India". Ohio University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1153856401.
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Robinette, Paul. "Developing robots that impact human-robot trust in emergency evacuations". Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54415.
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High-risk, time-critical situations require trust for humans to interact with other agents even if they have never interacted with the agents before. In the near future, robots will perform tasks to help people in such situations, thus robots must understand why a person makes a trust decision in order to effectively aid the person. High casualty rates in several emergency evacuations motivate our use of this scenario as an example of a high-risk, time-critical situation. Emergency guidance robots can be stored inside of buildings then activated to search for victims and guide evacuees to safety. In this dissertation, we determined the conditions under which evacuees would be likely to trust a robot in an emergency evacuation.
We began by examining reports of real-world evacuations and considering how guidance robots can best help. We performed two simulations of evacuations and learned that robots could be helpful as long as at least 30% of evacuees trusted their guidance instructions. We then developed several methods for a robot to communicate directional information to evacuees. After performing three rounds of evaluation using virtually, remotely and physically present robots, we concluded that robots should communicate directional information by gesturing with two arms. Next, we studied the effect of situational risk and the robot's previous performance on a participant's decision to use the robot during an interaction. We found that higher risk scenarios caused participants to align their self-reported trust with their decisions in a trust situation. We also discovered that trust in a robot drops after a single error when interaction occurs in a virtual environment. After an exploratory study in trust repair, we have learned that a robot can repair broken trust during the emergency by apologizing for its prior mistake or giving additional information relevant to the situation. Apologizing immediately after the error had no effect.
Robots have the potential to save lives in emergency scenarios, but could have an equally disastrous effect if participants overtrust them. To explore this concept, we created a virtual environment of an office as well as a real-world simulation of an emergency evacuation. In both, participants interacted with a robot during a non-emergency phase to experience its behavior and then chose whether to follow the robot’s instructions during an emergency phase or not. In the virtual environment, the emergency was communicated through text, but in the real-world simulation, artificial smoke and fire alarms were used to increase the urgency of the situation. In our virtual environment, we confirmed our previous results that prior robot behavior affected whether participants would trust the robot or not. To our surprise, all participants followed the robot in the real-world simulation of an emergency, despite half observing the same robot perform poorly in a navigation guidance task just minutes before. We performed additional exploratory studies investigating different failure modes. Even when the robot pointed to a dark room with no discernible exit the majority of people did not choose to exit the way they entered.
The conclusions of this dissertation are based on the results of fifteen experiments with a total of 2,168 participants (2,071 participants in virtual or remote studies conducted over the internet and 97 participants in physical studies on campus). We have found that most human evacuees will trust an emergency guidance robot that uses understandable information conveyance modalities and exhibits efficient guidance behavior in an evacuation scenario. In interactions with a virtual robot, this trust can be lost because of a single error made by the robot, but a similar effect was not found with real-world robots. This dissertation presents data indicating that victims in emergency situations may overtrust a robot, even when they have recently witnessed the robot malfunction. This work thus demonstrates concerns which are important to both the HRI and rescue robot communities.
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Kim, Hyeon Jin. "The impact of learning on low-skilled workers' skill-improvement". Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1243956905.
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Alabdullatif, Abdulrahman M. "Impact of Lighting on Human Biomechanical Response During Lifting in Confined Spaces". University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479809352830833.
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Escarré, Urueña Roberto. "The higher education role in building human capital. Impact evaluation of higher education capacity building interventions in developing countries". Doctoral thesis, Universidad de Alicante, 2015. http://hdl.handle.net/10045/54051.
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The pivotal role of Higher Education (HE) for the progression of developing countries is widely acknowledged. Higher Education contributes to, among other important aspects, the generation of human capital for later incorporation into important sectors such as healthcare, agriculture, new technologies, or tourism. Important international donor agencies already acknowledge this fact, particularly within the past decade. Since the beginning of the new millennium, Higher Education has acquired a prominent position on their agendas, and a notable increase in funding has been observed. In this framework, Capacity Building (CB) interventions have one of the preferred actions by donors since the eighties, due to the influence of the Human Capital Theory (and Endogenous Growth Models) in the development assistance domain. These interventions, in the field of Higher Education in developing countries, might adopt different approaches: individual (via scholarships to students), organizational (via consortia or networks between universities, targeting Higher Education institutions), and societal (via projects targeting some aspects of the Higher Education systems). Despite the fact that HE CB interventions in developing countries are becoming more popular little research and monitoring has been done to understand the impact of these multiple types of interventions neither by academics, donors or policymakers. By considering these gaps, the aim of this research was to propose an evaluation and monitoring framework for specific HE CB interventions that will allow to explore the human capital benefits of these types of interventions. The study approaches this aim from different angles: by strengthening the links between key concepts form different fields, providing a better understanding of the types of HE CB interventions and proposing methods to measure the impact which are, in turn, empirically tested during the research. The study adopts different methodologies according to the research aims. A combination of mixed qualitative and quantitative methods was chosen to analyse two selected case studies. The first was a HE CB programme for Latin American Deans chosen to observe its impacts for the participating individuals. Based on this case study, a new methodological tool was proposed to assess individual HE CB interventions at mid and long-term. The second case study involved a sample of worldwide HE CB programme practitioners engaged through the participatory methodology of a Delphi survey to observe their perceptions about the impact of different programmes at multiple levels: individual, organisational and societal. Through this multiple approach, the study makes a number of contributions. First, it adds to the literature combining both the Economics of Education and CB by contributing to the academic debate from the theory and specially providing new empirical evidences. Second, the study proposes new forms of measuring the impact some of which are empirically tested and validated though the positive results of this study, while others will need to be further developed and tested in future research. In summary, through all the different case studies selected, the research has contributed to provide better evidence of the impact and benefits of HE CB interventions to inspire more efficient programmes and better evidence-based policies that could contribute to the development of these countries.
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Jolly, Johannes E. "Impact analysis of a biomechanical model of the human thorax". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA379713.
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Thesis (M.S. in Physics)--Naval Postgraduate School, June 2000.Thesis advisor(s): Kwon, Young W. ; Baker, Steven R. "June 2000." Includes bibliographical references (p. 89-90). Also available online.
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El-Sayed, Moustafa Julia Sarah. "Genomic structural variation and its impact on the human phenotype". Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39129.
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The impact of genomic structural variation on the human phenotype and the degree to which it contributes to the unexplained heritability of complex disease is of considerable interest, particularly as rapidly rising rates of metabolic disorders have placed increased impetus on identification of genetic factors influencing individual susceptibility to obesity. The work presented in this thesis focusses on the role of genomic structural variants (GSVs) in the modulation of adiposity and pathogenesis of obesity. Common CNVs were investigated in two severe obesity case-control study samples. Eight intragenic and five intergenic CNVs were significantly associated with increased susceptibility to obesity (P < 2.0??10-6), eight of which were located within variable number of tandem repeats (VNTRs). Investigation of a complex copy number variable region on 8p21.2 encompassing the dedicator of cytokinesis 5 (DOCK5) gene revealed the presence of two complex VNTRs flanking a common deletion. We have developed a novel VNTR association algorithm, VNTRtest, which we employed to show significant association of the DOCK5 VNTRs with childhood and adult obesity (P=3.7??10-9 and P=3.1??10-3, respectively), as well as independent association between the 3,975bp deletion and obesity (P=1.6??10-3). We have also shown copy number at the multi-allelic salivary amylase gene (AMY1) to be strongly associated with both adiposity and obesity susceptibility, replicating this finding in six Caucasian study samples. Carriers of low versus high copy numbers at AMY1 showed increased risk of obesity (OR [95%CI]=10.50 [5.19-22.53]; P=2.71??10-10). Copy-numbers at this locus were also correlated with serum amylase levels, which also showed inverse correlation with body mass index. Additionally, rare duplications above 500kb were significantly enriched in child and adult obesity (P=8.89??10-3 and P=9.78??10-3, respectively). Functional annotation analysis also revealed enrichment for genes associated with schizophrenia within GSVs identified in obese subjects (P=2.2??10-5). In summary, this thesis presents multiple novel GSV associations with obesity as well as methodology for GSV genotyping and association testing. It is hoped that the work described in this thesis may contribute towards elucidation of the role of genomic structural variation in complex disease.
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Sieswerda, Lee Edward. "Towards measuring the impact of ecological desintegrity on human health". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0025/MQ40111.pdf.
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Benz, Susanne [Verfasser] y Patrick [Akademischer Betreuer] Blum. "Human Impact on Groundwater Temperatures / Susanne Benz ; Betreuer: P. Blum". Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1124903003/34.
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Thalmann, Vanessa. "Prison labour for private corporations : the impact of human rights". Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82672.
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In the past two decades, the prison population has increased considerably in many industrialized countries. In the United States, for example, the prison population has more than quadrupled since 1980. As a response to the considerable incarceration costs, the number of private prisons and the number of prisoners working for private corporations have increased significantly. Proponents of private sector involvement in prison industries argue that inmate labour can reduce the incarceration costs and contribute to rehabilitation of prisoners.The question of private sector involvement in prison facilities raises significant concerns as regards to international labour standards. Opponents of private sector involvement argue that private hiring of prison labour can involve exploitation. They also argue that the authority for punishment is a core governmental function that cannot be delegated to the private sector. Furthermore, in most cases, labour and social security laws are not applied to inmates. Therefore, prison labour can constitute unfair competition with free labour or even go as far as to replace free labour.
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Andric, Maja. "Transition to farming and human impact on the Slovenian landscape". Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365514.
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Lomax, Tim Matthew. "Holocene vegetation history and human impact in Western Lewis, Scotland". Thesis, University of Birmingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529393.
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Couey, James S. y Randal Alan Dragon. "The impact of human factors on decision making in combat". Thesis, Monterey, California: Naval Postgraduate School, 1990. http://hdl.handle.net/10945/27733.
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Approved for public release; distribution is unlimited.This thesis identifies those human factors which impact on a commander's decision in a tactical combat environment. Various models for categorization are discussed. The study argues that in order to establish clear causaleffect relationships between human factors and battle outcome, concentration of analytical research must focus on first order effects. Two categorical judgment surveys in the form of questionnaires are developed. Results from the surveys are transformed to interval scales. The first survey is exploratory in nature and allows respondents to apply 27 endogenous factors within a generic tactical context. The second survey presents four specific tactical scenarios in which the top seven factors identified in the first survey can be applied. Respondent selection for the first survey represented the four military services while respondent selection for the second survey was limited to Army officers. The study concludes that the top seven factors are: Leadership, TrainingExperience, Initiative, Discipline, Cohesion, Morale, and WillMotivation. The rank order and scaled magnitudes of these factors are found to be scenario dependent.
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Coombes, Paul Melor Vernon. "The palaeoecology of recent human impact in the Lake District". Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396760.
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Sinilkina, А. y L. Royenko. "The unpredictable impact of human behavior on the economic processes". Thesis, КНУТД, 2016. https://er.knutd.edu.ua/handle/123456789/5027.
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Shvachko, D. "Hardness of water and its impact on the human body". Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/62813.
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We all know that water is one of the most important molecules in the earth and the human body, so our work is dedicated to the research of the physical parameter as water hardness and its impact on the human body. It is known that hard water can have a negative impact not only on the technical and communication devices, but also on living beings. Therefore, the research of the effect of this indicator, depending on its quantitative value to the organism in any region is very important.
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Van, Herwerden L. "Human recreational activity and its impact on a metropolitan coastline". Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/14356.
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Includes bibliography.Recreation has an important social function in modern societies, with ever-increasing pressures in the day-to-day life being felt by most people. This study addresses the impact of recreational activity on metropolitan shorelines, with particular reference to the False Bay shoreline. During summer holiday periods shoreline utilization in the Western Cape peaks on the public holidays of 26 December, 1 and 2 January, beach attendances reaching levels of 2 to 10 times higher than attendances on other days during the summer holidays. The greatest proportion of visitors to the beach (94%) engage in non-exploitative activities, such as sunbathing and swimming. Most visitors occur on the beaches between 12h00 and 16h00, week-ends being most popular during out-of-season periods, but in-season week day attendances exceed those of weekends. Only 6% of visitors surveyed were engaged in exploitative activities such as angling and bait- or food-gathering. Conservation awareness of visitors to the shore is related to the place of residence of the person, as well as activity engaged in by the person. Fish numbers and their size frequency distributions in protected areas differs to those of unprotected areas. If boulders on a sheltered shore are over-turned during bait gathering it has an adverse effect on the boulder communities, whether the boulders are replaced or left over-turned. When bait gatherers target on mussel-worms as bait, they may cause inadvertent damage to the primary matrix of mussel bed or tube-worm reef in the process, thereby affecting ecological succession processes in the intertidal environment. Management of metropolitan shorelines must therefore provide for quality recreational experiences, while applying conservation measures to selected areas that are susceptible to over-exploitation under the onslaught of ever-increasing numbers of recreationists. For such measures to be of any benefit to the marine environment, it is essential that people are not only informed, but that the regulations are also properly enforced.
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Benz, Susanne Amelie [Verfasser] y Patrick [Akademischer Betreuer] Blum. "Human Impact on Groundwater Temperatures / Susanne Benz ; Betreuer: P. Blum". Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1124903003/34.
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Cunha, Virgínia Filipa Pereira Monteiro da. "Human adipose tissue primary cultures and impact in prostate cancer". Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/8985.
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Mestrado em Biologia Aplicada - Molecular e CelularProstate cancer (Pca) is one of the most frequent diagnosed neoplasies and the second cause of cancer-related death in the world, in men. Between others risk factors, obesity has been associated to Pca although the innerent mechanisms to this association remain to be clear. With this work, throuhg in vitro studies, we wish to contribute to the understanding of the impact of white adipose tissue and its sub-fractions (adipocytes and stromal vascular fraction), from visceral and periprostatic anatomic regions, in celular proliferation, apoptosis and invasion of castration sensitivity (LNCaP) and castration resistant (PC-3) prostate cells. With the purpose of obtaining answers directly from humam studies, were performed visceral and periprostatic adipose tissue primary cultures obtained during urologic surgeries (radical prostatectomy and prostatic adenomectomy) (n=16). Adipose tissue was used to make primary organotipical cultures (WAT) and after collagenase digestion adipocytes and SVF primary cultures. Sobrenatants and infranatants of each culture were collect and used as conditioned medium representing adipokines production. LNCaP and PC-3 cell lines were stimulated with these mediums and apoptosis, proliferation and invasion were evaluated, in vitro. This study model represent a potential form for analyze the impact of adipose tissue in tumor cells, allowing to evaluate adipose tissue-tumor interactions. The results show that adipose tissue promotes tumor cells proliferation, that periprostatic adipose tissue increase apoptosis in obese individuals and that SVF subfraction suppresses invasion of PC-3 cells through a direct effect in tumor cells.
O Cancro da próstata (CaP) é uma das neoplasias mais frequentemente diagnosticadas e a segunda causa de morte por cancro no mundo nos homens. Entre outros factores de risco, a obesidade tem sido frequentemente associada a CaP, embora permaneçam por esclarecer os mecanismos subjacentes a esta associação. Com o presente trabalho pretendeu-se através de estudos in vitro, contribuir para a compreensão do impacto do tecido adiposo branco e suas sub-fracções (adipócitos e fracção vascular estromal), com origens anatómicas periprostática e viceral, na proliferação, apoptose, e invasão celular de células de cancro da próstata sensíveis à castração (LNCaP) e resistentes à castração (PC-3). Com o propósito de obter respostas directamente através de estudos em humanos, foram efectuadas culturas primárias de tecido adiposo periprostático e visceral obtido durante cirurgias urológicas (prostatectomia radical e adenomectomia prostática) (n=16). O tecido adiposo foi utilizado para realizar culturas primárias organotípicas (tecido adiposo total fraccionado) e após digestão com colagenase culturas primárias de adipócitos e de células da fracção vascular estromal do tecido adiposo. Foram colhidos sobrenadantes e infranadantes destas culturas de tecido adiposo e utilizados como meios condicionados representativos da produção de adipocinas. As linhas celulares LNCaP e PC-3 foram estimuladas com estes meios e avaliados a apoptose, proliferação celular e invasividade tumoral in vitro. Este modelo de estudo representa um potencial meio para análise do impacto do tecido adiposo nas células tumorais, permitindo avaliar as interacções tecido adiposo-tumor. Os resultados evidenciam que o tecido adiposo promove a proliferação das células tumorais, que o tecido adiposo periprostático aumenta a apoptose em indivíduos obesos e que os SVF suprimem a invasão das PC-3 através de um efeito directo nas células tumorais.
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Juarez, Jessica K. "Validation study of blunt force impact to the human cranium". Cincinnati, Ohio : University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1242834279.
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Thesis (M.A.)--University of Cincinnati, 2009.Advisor: Alan P. Sullivan, III. Title from electronic thesis title page (viewed Aug. 11, 2009). Includes abstract. Keywords: blunt force; cranium. Includes bibliographical references.
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Couey, James S. Dragon Randal Alan. "The impact of human factors on decision making in combat /". Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA232760.
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Thesis (M.S. in Systems Technology (Command, Control, and Communications))--Naval Postgraduate School, June 1990.Thesis Advisor(s): Parry, Samuel H. Second Reader: Hoffman, James C. "June 1990." Description based on signature page as viewed on October 21, 2009. DTIC Identifier(s): Human factors engineering, decision making, combat forces, surveys, theses, environmental factors, MANPRINT, combat modeling, command and control, mathematical analysis. Author(s) subject terms: Combat modeling, combat performance, command and control, decision-making, environmental factors, human factors, MANPRINT. Includes bibliographical references (p. 209-213). Also available online.