Literatura académica sobre el tema "Human Genome Project"

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Artículos de revistas sobre el tema "Human Genome Project"

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Kim, Myung Hee. "Human Genome Project". Journal of the Korean Medical Association 40, n.º 12 (1997): 1680. http://dx.doi.org/10.5124/jkma.1997.40.12.1680.

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Sawicki, Mark P., Ghassan Samara, Michael Hurwitz y Edward Passaro. "Human Genome Project". American Journal of Surgery 165, n.º 2 (febrero de 1993): 258–64. http://dx.doi.org/10.1016/s0002-9610(05)80522-7.

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Travis, John. "Another Human Genome Project". Science News 153, n.º 21 (23 de mayo de 1998): 334. http://dx.doi.org/10.2307/4010387.

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Sillence, David. "The Human Genome Project". Medical Journal of Australia 152, n.º 9 (mayo de 1990): 486–88. http://dx.doi.org/10.5694/j.1326-5377.1990.tb125310.x.

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ROSSITER, BELINDA J. F. y C. THOMAS CASKEY. "The Human Genome Project". Clinical Obstetrics and Gynecology 36, n.º 3 (septiembre de 1993): 466–75. http://dx.doi.org/10.1097/00003081-199309000-00005.

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Olson, M. V. "The human genome project." Proceedings of the National Academy of Sciences 90, n.º 10 (15 de mayo de 1993): 4338–44. http://dx.doi.org/10.1073/pnas.90.10.4338.

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GREEN, ERIC D. y ROBERT H. WATERSTON. "The Human Genome Project". Obstetrical & Gynecological Survey 47, n.º 5 (mayo de 1992): 319–21. http://dx.doi.org/10.1097/00006254-199205000-00014.

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Elias, Sherman. "The Human Genome Project". Obstetrical & Gynecological Survey 48, n.º 7 (julio de 1993): 441–42. http://dx.doi.org/10.1097/00006254-199307000-00001.

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Eaton, L. "Human genome project completed". BMJ 326, n.º 7394 (19 de abril de 2003): 838b—838. http://dx.doi.org/10.1136/bmj.326.7394.838/b.

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Powledge, Tabitha M. "Human genome project completed". Genome Biology 4 (2003): spotlight—20030415–01. http://dx.doi.org/10.1186/gb-spotlight-20030415-01.

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Tesis sobre el tema "Human Genome Project"

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Kozman, Helen. "The development of the genetic map of human chromosome 16 by linkage analysis /". Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phk884.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Paediatrics, Women's and Children's Hospital, 1995.
Includes publications and manuscripts by the author. Includes bibliographical references (leaves 196-215).
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Tutton, Richard. "Representation and participation in the European Human Genome Diversity Project". Thesis, Lancaster University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289047.

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Gill, Josephine Ceri. "Race, genetics and British fiction since the Human Genome Project". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610822.

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Paudel, Rajan. "An Investigation into the Evolution of Nucleotide Composition in the Human Genome". University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1564404055416097.

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McKeveney, Paul J. "Characterisation of novel erythropoietin-responsive genes". Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301746.

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Allender-Hagedorn, Susan. "Arguing the Genome: A Topology of the Argumentation Behind the Construction of the Human Genome Project". Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/28834.

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The Human Genome Project (HGP), the name given to the scientific program to map and decode all of human genetic material, has been projected to revolutionize the conduct of biological science in the twenty-first century. For several years before its formation in 1990, a federally-funded, systematic study of the human genome was discussed first in the scientific arena and then in the public arena. The central thesis of this dissertation is that the arguments supporting or rejecting creation of the HGP and the rhetorical devices used to further those arguments had a major influence on the shape the HGP took in 1991. The argumentation used both for and against the creation of the HGP before the public as well as on the border between the public and scientific arenas is studied. The rhetorical devices such as metaphor, narrative, and selective word choices used to further these arguments are also examined. In particular, a rhetorical content analysis was performed on the 1986-1991 argumentation available to the most crucial audience for such persuasion: the members of Congress who ultimately voted for or against the program's funding and its establishment as a part of U.S. science policy. The proponents of the HGP, especially after the first year of public debate, presented their arguments in a wider arena of discussion and presented more and more varied arguments to advocate the project. The opposition raised questions that had for the most part been answered earlier in the debate. Often anti-HGP arguments focused on less effective audiences (scientists instead of members of Congress). Opposition to the project didn't become organized until near the end of the time frame studied, too late to have much of an impact on the outcome of the debate. The rhetorical devices studied served to magnify the impact of arguments used: in particular, the metaphor served as a boundary object to bridge discussions between the scientific and the public arenas. Ultimately the victory in the debate over the establishment of the HGP was awarded to the promulgators of the strongest underlying metaphor--the idealized excitement and profit of exploration of unknown territory--and the benefits to come from filling in and conquering the unknown areas of the human genetic map, territory the U.S. was eager to claim for its own.
Ph. D.
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Hallam, Adrienne Louise. "Globalisation, Human Genomic Research and the Shaping of Health: An Australian Perspective". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367541.

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This thesis examines one of the premier "big science" projects of the contemporary era - the globalised genetic mapping and sequencing initiative known as the Human Genome Project (HGP), and how Australia has responded to it. The study focuses on the relationship between the HGP, the biomedical model of health, and globalisation. It seeks to examine the ways in which the HGP shapes ways of thinking about health; the influence globalisation has on this process; and the implications of this for smaller nations such as Australia. Adopting a critical perspective grounded in political economy, the study provides a largely structuralist analysis of the emergent health context of the HGP. This perspective, which embraces an insightful nexus drawn from the literature on biomedicine, globalisation and the HGP, offers much utility by which to explore the basis of biomedical dominance, in particular, whether it is biomedicine's links to the capitalist infrastructure, or its inherent efficacy and efficiency, that sustains the biomedical paradigm over "other" or non-biomedical health approaches. Additionally, the perspective allows for an assessment of whether there should be some broadening of the way health is conceptualised and delivered to better account for social, economic, and environmental factors that affect living standards and health outcomes, and also the capacity of globalisation to promote such change. These issues are at the core of the study and provide the theoretical frame to examine the processes by which Australian policy makers have given an increasing level of support to human genomic research over the past decade and also the implications of those discrete policy choices. Overall, the study found that globalisation is renewing and extending the dominance of the biomedical model, which will further marginalise other models of health while potentially consuming greater resources for fewer real health outcomes. While the emerging genomic revolution in health care may lead to some wondrous innovations in the coming decades, it is also highly likely to exacerbate the problems of escalating costs and diminishing returns that characterise health care systems in industrialised countries, and to lead to greater health inequities both within and between societies. The Australian Government has chosen to underwrite human genomic research and development. However, Australia's response to the HGP has involved both convergences and variations from the experiences of more powerful industrial nations. The most significant divergence has been in industry and science policy, where until the mid-1990s, the Australian Government displayed no significant interest in providing dedicated research funding, facilities, or enabling agencies to the emerging field. Driven by the threat of economic marginalisation and cultural irrelevance, however, a transformation occurred. Beginning with the Major National Research Facilities Program of the Department of Industry, Science and Technology, and then the landmark Health and Medical Research Strategic Review, support for human genomic research grew strongly. Comprehensive policy settings have recently been established to promote the innovation, commercialisation, promotion and uptake of the products of medical biotechnology and genomics. As such, local advocates of a broader model of health will be forced to compete on the political and economic stage with yet another powerful new area of biomedicine, and thus struggle to secure resources for perhaps more viable and sustainable approaches to health care in the 21st century.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Science
Faculty of Science
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Tobin, Allison Claire Simmons. "Patenting human genetic sequences : a comparative analysis of intellectual property protection policies". Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/31043.

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Balmer, Brian L. "Mutations in the research system? The Human Genome Mapping Project as science policy". Thesis, University of Sussex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358200.

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The way in which scientific research is conceived, organized and practiced in the context of shifting policies and institutional structures is the main focus of this thesis. The empirical component examines the development of the UK Human Genome Mapping Project (HGMP), the British contribution to the international plan to locate all of the genes in the human species. A comparative case-study examines the unsuccessful attem pts by Australian scientists to establish a national genome mapping initiative. Two main sets of research questions are posed. Why was the HGMP set up in the UK at the end of the 1980s when, prima facie, a number of factors suggested that an organized project would not be established? Allied to this question is the comparative one of how and why a project was successfully established in the UK but not in Australia? The second major question asks how policy subsequently developed for the UK programme: what factors shaped policy-making, what aspects of science did the programme shape? Drawing on recent developments in sociology of science and science policy studies, it is argued that in both Australia and the UK debates over whether to have a genome project, and the subsequent developments in UK policy towards the project, were not straightforward administrative choices. In both countries, the question of what was the best science to support was translated into debates over the best way to do science, what scientific knowledge was for and even what was to count as worthwhile knowledge. The implicit and explicit answers to those questions by various groups were embodied in policies and policy recommendations. The thesis concludes that differing expectations concerning the role of science had to be orchestrated together in order to mobilize, and subsequently maintain, support for gene mapping and sequencing.
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Pagani, Luca. "Through the layers of the Ethiopian genome : a survey of human genetic variation based on genome-wide genotyping and re-sequencing data". Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/251330.

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Understanding our evolutionary history as a species has since long been one of the most attracting and controversial themes of the scientific investigation. From its geographical position, outstanding fossil record and richness of human diversity, the Horn of Africa and, particularly, the Ethiopian region offers an unmatched opportunity to investigate our origins from a genetic perspective. To carry out a genome-wide survey of this region, 13 out of the estimated 80 extant Ethiopian populations were typed on an Illumina Omni 1M SNP array. The results showed a good concordance between genetic and linguistic stratification and, overall, a complex population structure placing the Ethiopians in between North and Sub Saharan Africans, due to the recent non African gene flow which was dated at around 3000 years ago. Furthermore the SNP array data unveiled putative traces of the out of Africa migrations as well as, in two of the typed populations, signatures of genetic adaptation to high altitude. To obtain an unbiased, high resolution representation of the Ethiopian genetic landscape, 25 individuals from each of five populations were newly collected and sequenced on an Illumina HiSeq platform. These populations were chosen, from among the ones typed on the SNP array, to represent the main components of Ethiopian genetic diversity. Of the 25 samples per population, 24 were sequenced at low depth to generate a broad list of genetic variants, while one sample from each was sequenced at high depth to provide a higher resolution list of variants peculiar to each analysed population. The 125 Ethiopian genomes thus sequenced, while overall consistent with the genotyping results, described the Ethiopian populations in a less biased way than the SNP array data. Furthermore estimation of past effective population size fluctuations from the individual genomes unveiled a unique pattern in the ancestry of the Ethiopian populations in the early stages of human evolution. These results provide a data resource which can be used in future analyses.
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Libros sobre el tema "Human Genome Project"

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Lee, Thomas F. The Human Genome Project. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-6022-1.

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Grant, Cooper Necia y Center for Human Genome Studies (Los Alamos National Laboratory), eds. The Human Genome Project. Los Alamos, N.M: Los Alamos National Laboratory, 1992.

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The Human genome. Oxford, UK: Bios Scientific Publishers, 1992.

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Palladino, Michael Angelo. Understanding the human genome project. 2a ed. San Francisco: Pearson/Benjamin Cummings, 2006.

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Cherfas, Jeremy. The human genome. New York: DK Pub., 2002.

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Marshall, Elizabeth L. The Human Genome Project: Cracking the code within us. New York: F. Watts, 1996.

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Ballen, Karen Gunnison. Mapping the genome: Human Genome Project vs. Craig Venter. Minneapolis: Twenty-First Century Books, 2013.

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Ballen, Karen Gunnison. Mapping the genome: Human Genome Project vs. Craig Venter. Minneapolis: Twenty-First Century Books, 2013.

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Carina, Dennis y Gallagher Richard B, eds. The human genome. New York: Nature/Palgrave, 2001.

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Vizcaya, Fundación Banco Bilbao. The Human Genome Project: Legal aspects. Bilbao: Fundación BBV, 1994.

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Capítulos de libros sobre el tema "Human Genome Project"

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Orbell, Sheina, Havah Schneider, Sabrina Esbitt, Jeffrey S. Gonzalez, Jeffrey S. Gonzalez, Erica Shreck, Abigail Batchelder et al. "Human Genome Project". En Encyclopedia of Behavioral Medicine, 1003–4. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_704.

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Tsui, Nancy B. Y. y Johnson Y. N. Lau. "Human Genome Project". En Encyclopedia of Gerontology and Population Aging, 1–6. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-69892-2_1042-1.

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Salem, Rany M. y Laura Rodriguez-Murillo. "Human Genome Project". En Encyclopedia of Behavioral Medicine, 1112–13. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_704.

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Lopes, Guilherme S. y Yael Sela. "Human Genome Project". En Encyclopedia of Personality and Individual Differences, 2053–56. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-24612-3_724.

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Lopes, Guilherme S. y Yael Sela. "Human Genome Project". En Encyclopedia of Personality and Individual Differences, 1–4. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28099-8_724-1.

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Tsui, Nancy B. Y. y Johnson Y. N. Lau. "Human Genome Project". En Encyclopedia of Gerontology and Population Aging, 2479–84. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-22009-9_1042.

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Lindsey, Gillian. "Human Genome Project". En Encyclopedia of Genetics, 606–12. New York: Routledge, 2014. http://dx.doi.org/10.4324/9781315073972-86.

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Mainieri, Avantika. "Human Genome Project, The". En Encyclopedia of Evolutionary Psychological Science, 1–3. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-16999-6_2227-1.

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Jameson, J. Larry. "The Human Genome Project". En Principles of Molecular Medicine, 59–63. Totowa, NJ: Humana Press, 1998. http://dx.doi.org/10.1007/978-1-59259-726-0_5.

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Tramper, Johannes y Yang Zhu. "The Human Genome Project". En Modern Biotechnology, 227–45. Wageningen: Wageningen Academic Publishers, 2011. http://dx.doi.org/10.3920/978-90-8686-725-7_13.

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Actas de conferencias sobre el tema "Human Genome Project"

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CHU, JIAYOU. "CHINESE HUMAN GENOME DIVERSITY PROJECT: A SYNOPSIS". En Genetic, Linguistic and Archaeological Perspectives on Human Diversity in Southeast Asia. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812810847_0008.

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Davidson, S. B., A. S. Kosky y B. Eckman. "Facilitating transformations in a human genome project database". En the third international conference. New York, New York, USA: ACM Press, 1994. http://dx.doi.org/10.1145/191246.191317.

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Dahl, Carol A. y Robert L. Strausberg. "Human genome project: revolutionizing biology through leveraging technology". En Photonics West '96, editado por Gerald E. Cohn, Steven A. Soper y C. H. Winston Chen. SPIE, 1996. http://dx.doi.org/10.1117/12.237605.

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CONNEALLY, P. MICHAEL. "THE HUMAN GENOME PROJECT: ITS IMPACT ON COMPLEX DISORDERS". En Proceedings of the International Seminar on Nuclear War and Planetary Emergencies — 27th Session. WORLD SCIENTIFIC, 2003. http://dx.doi.org/10.1142/9789812705150_0045.

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Hansma, Helen G. y Paul K. Hansma. "Potential applications of atomic force microscopy of DNA to the human genome project". En OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, editado por Richard A. Keller. SPIE, 1993. http://dx.doi.org/10.1117/12.146705.

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Williams, Peter W., David Schieltz, Randall W. Nelson, Chau-Wen Chou, Cong-Wen Luo y Robert Thomas. "Time-of-flight mass spectrometry of DNA laser-ablated from frozen aqueous solutions: applications to the Human Genome Project". En OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, editado por Richard A. Keller. SPIE, 1993. http://dx.doi.org/10.1117/12.146708.

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Ecklund, Denise J. "MASSIVELY PARALLEL PROCESSING ON THE INTEL PARAGON SYSTEM: ONE TOOL IN ACHIEVING THE GOALS OF THE HUMAN GENOME PROJECT". En Proceedings of the 2nd International Conference. WORLD SCIENTIFIC, 1993. http://dx.doi.org/10.1142/9789814503655_0021.

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Kim, Moon K., Byeongsoo Lim y Wing Kam Liu. "Multiscale Elastic Network Model for Macromolecular Machines". En ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13090.

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In the early year of this century the human genome sequencing project was successfully completed so that we can understand all the human genes and their corresponding protein sequences. Now our interests have naturally moved from genetics to proteomics in which we challenge to elucidate the relationship between functions and structures of proteins. In particular, understanding large conformational changes occurring at molecular machinery systems or protein assemblies have received great attentions. However, it has been rarely studied both experimentally and theoretically because of limitation of experimental setup for capturing real time protein dynamics and computing power, respectively.
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onoda, Takashi y Yasunobu Ito. "Academic Researchers' Voluntary Incentives in Technology Transfer: An ethnographic case study of genome science". En 15th International Conference on Applied Human Factors and Ergonomics (AHFE 2024). AHFE International, 2024. http://dx.doi.org/10.54941/ahfe1005108.

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The predominant contributors to the advancement of medical devices have traditionally resided within the industrial sector. Nevertheless, owing to recent progress in open innovation and other contributing factors, academia has experienced a notable surge in research and development activities. In 2015, the Japanese government inaugurated the Japan Agency for Medical Research and Development (AMED), aspiring to emulate the National Institutes of Health (NIH) in the United States, with the objective of fostering the creation of medical devices originating from academic endeavors. In the realm of medical devices utilized for diagnostic, therapeutic, preventative, or monitoring purposes, there is a growing focus not only on therapeutic and diagnostic devices but also on the burgeoning significance of simple genetic diagnosis as a testing modality. The application of genetic diagnosis has extended beyond rare diseases to encompass the treatment of common ailments such as cancer, manifesting a notable expansion in recent years. Projections indicate that by 2025, the global market is poised to reach $13.2 billion, a threefold increase from the 2017 level, with further growth anticipated in tandem with heightened research and development undertakings. Despite these promising prospects, the facilitation of medical device development within academia encounters formidable challenges. Issues such as funding constraints, legal constraints, and limited collaboration with industry are universally acknowledged hurdles. Of particular concern is the sustainable promotion of these activities by researchers within academic institutions. Historically, addressing societal implementation concerns related to technology transfer and commercialization has fallen under the purview of liaison personnel, who act as intermediaries between industry and academia. However, existing support structures primarily address external aspects, presenting challenges in offering comprehensive solutions. Additionally, the imperative of devising mechanisms to ensure incentives for academic researchers is a critical aspect of sustainable activities, constituting a prominent challenge. Consequently, this study places emphasis on the cognitive culture or background—the epistemic culture inherent in the consciousness of actors engaged in research and development. Employing a multi-site ethnographic survey encompassing research institutions and facilities affiliated with the participating actors, alongside in-depth interviews, the study endeavors to shed light on the cultural aspects of knowledge intrinsic to the awareness of participating actors and their backgrounds. A protracted ethnographic and interview survey will be conducted among researchers involved in the "Cancer Biomarker Discovery Project" within academic research organizations. The aim is to elucidate the cultural dimensions of knowledge inherent in the consciousness of participating actors and to identify the challenges associated with medical device development within academia. Through survey analysis, this research will address the issue of securing voluntary incentives for researchers, a recognized concern in the context of medical device development within academia. The anticipated outcome is the elucidation of guidelines and promotional strategies for ensuring voluntary incentives, thereby fostering the revitalization of medical device development within academic settings.
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Liang, Yun, Keith M. Stantz, Ganapathy Krishnamurthi, Laigao Chen y Gary D. Hutchins. "Investigation of Contrast-Enhanced In-Vivo Animal Imaging With Micro-CT". En ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33053.

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Rapid progress in molecular biology, much sparked by the human Genome Project, is opening a new era in medicine and biology. The development of in-vivo micro-imaging technology for small animals (mice and rats) has generated unprecedented opportunities for studying the structural and physiologic properties exhibited by different genes in a cost-effective and low-risk means. This knowledge, in turn, will help guide the study in human genetic system. Micro-computed tomograph (microCT) with resolution on the scale of micrometer is a new technique for obtaining the 3D images of the internal structure of small objects [1,2]. Its biological and medical applications include noninvasively screening animals for genetic mutations and identification as well as monitoring of structural and physiology properties that are linked with specific genes. This paper reports on our preliminary investigation on two aspects of this new imaging technique: (1) an initial experience of instrumentation capability and limitation, and (2) the contrast enhancement strategy necessary for organ-specific anatomic and physiologic studies.
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Informes sobre el tema "Human Genome Project"

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Block, S., J. Cornwall, W. Dally, F. Dyson, N. Fortson, G. Joyce, H. J. Kimble et al. Human Genome Project. Office of Scientific and Technical Information (OSTI), enero de 1998. http://dx.doi.org/10.2172/1184016.

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Kitcher, P. Implications of the Human Genome Project. Office of Scientific and Technical Information (OSTI), noviembre de 1998. http://dx.doi.org/10.2172/674918.

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Cook-Deegan, Robert. Origins of the Human Genome Project. Office of Scientific and Technical Information (OSTI), julio de 1993. http://dx.doi.org/10.2172/758721.

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Smith, S. D. G., M. S. Hutchinson y M. A. Flies. Neural networks and the human genome project. Office of Scientific and Technical Information (OSTI), febrero de 1989. http://dx.doi.org/10.2172/5769105.

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Grad, F. P. The lawful uses of knowledge from the Human Genome Project. Office of Scientific and Technical Information (OSTI), abril de 1994. http://dx.doi.org/10.2172/10155015.

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Cooper, N. G. y N. Shea. Los Alamos Science: The Human Genome Project. Number 20, 1992. Office of Scientific and Technical Information (OSTI), enero de 1992. http://dx.doi.org/10.2172/10161960.

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McInerney, J. D. y L. B. Micikas. The Human Genome Project: Information access, management, and regulation. Final report. Office of Scientific and Technical Information (OSTI), agosto de 1996. http://dx.doi.org/10.2172/402379.

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Yesley, M. S. ELSI Bibliography: Ethical legal and social implications of the Human Genome Project. Office of Scientific and Technical Information (OSTI), noviembre de 1993. http://dx.doi.org/10.2172/10108311.

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Eisenberg, R. S. The role of patents in technology transfer in Human Genome Project. Progress report. Office of Scientific and Technical Information (OSTI), abril de 1995. http://dx.doi.org/10.2172/88843.

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Sara L. Tobin. Getting the Word Out on the Human Genome Project: A Course for Physicians. Office of Scientific and Technical Information (OSTI), septiembre de 2004. http://dx.doi.org/10.2172/832850.

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