Literatura académica sobre el tema "Granule Neuron Progenitors"
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Artículos de revistas sobre el tema "Granule Neuron Progenitors"
Poudel, Phanindra Prasad, Chacchu Bhattarai, Arnab Ghosh y Sneha Guruprasad Kalthur. "Expression of ATOH1 gene and activated signaling pathways for the neurogenesis of cerebellar granule cells: A review". Neuroscience Research Notes 5, n.º 2 (28 de abril de 2022): 125. http://dx.doi.org/10.31117/neuroscirn.v5i2.125.
Texto completoGao, W. Q. y M. E. Hatten. "Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum". Development 120, n.º 5 (1 de mayo de 1994): 1059–70. http://dx.doi.org/10.1242/dev.120.5.1059.
Texto completoAiello, Giuseppe y Luca Tiberi. "TMOD-05. IN VIVO REPROGRAMMING OF POSTMITOTIC NEURONS INDUCES MEDULLOBLASTOMA". Neuro-Oncology 21, Supplement_6 (noviembre de 2019): vi263. http://dx.doi.org/10.1093/neuonc/noz175.1104.
Texto completoMayerl, Steffen, Andrea Alcaide Martin, Reinhard Bauer, Markus Schwaninger, Heike Heuer y Charles ffrench-Constant. "Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis". Cells 11, n.º 3 (2 de febrero de 2022): 524. http://dx.doi.org/10.3390/cells11030524.
Texto completoCui, Hong y Robert F. Bulleit. "Potassium chloride inhibits proliferation of cerebellar granule neuron progenitors". Developmental Brain Research 106, n.º 1-2 (marzo de 1998): 129–35. http://dx.doi.org/10.1016/s0165-3806(97)00204-6.
Texto completoYang, X. W., R. Zhong y N. Heintz. "Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49". Development 122, n.º 2 (1 de febrero de 1996): 555–66. http://dx.doi.org/10.1242/dev.122.2.555.
Texto completoHaldipur, P., I. Sivaprakasam, V. Periasamy, S. Govindan y S. Mani. "Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum". Biology Open 4, n.º 7 (15 de mayo de 2015): 865–72. http://dx.doi.org/10.1242/bio.009886.
Texto completoMani, Shyamala, Saranya Radhakrishnan, Rajit Narayanan Cheramangalam, Shalini Harkar, Samyutha Rajendran y Narendrakumar Ramanan. "Shh-Mediated Increase in β-Catenin Levels Maintains Cerebellar Granule Neuron Progenitors in Proliferation". Cerebellum 19, n.º 5 (3 de junio de 2020): 645–64. http://dx.doi.org/10.1007/s12311-020-01138-2.
Texto completoChatterjee, Anindo, Kaviya Chinnappa, Narendrakumar Ramanan y Shyamala Mani. "Centrosome Inheritance Does Not Regulate Cell Fate in Granule Neuron Progenitors of the Developing Cerebellum". Cerebellum 17, n.º 5 (16 de abril de 2018): 685–91. http://dx.doi.org/10.1007/s12311-018-0935-4.
Texto completoHa, Seungshin, Prem P. Tripathi, Ray A. Daza, Robert F. Hevner y David R. Beier. "Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis". Journal of Developmental Biology 8, n.º 3 (18 de septiembre de 2020): 20. http://dx.doi.org/10.3390/jdb8030020.
Texto completoTesis sobre el tema "Granule Neuron Progenitors"
Weeranantanapan, Oratai. "The role of L1-CNTNs in controlling SHH-induced proliferation of cerebellar granule neuron progenitors". Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6180/.
Texto completoBou-Rouphaël, Johnny. "A new role for Barhl1 in a cerebellar germinative zone as inhibitor of T-cell factors transcriptional activity". Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS009.
Texto completoThe human cerebellum hosts more than 50% of all brain neurons. Cerebellar granule neurons are the smallest and most abundant neurons. atonal homologue 1 (Atoh1)-expressing granule neuron progenitors (GNPs) emerge from the upper rhombic lip (URL), a germinative zone located in the cerebellar primordium and displaying features of a niche of neural stem cells. GNPs proliferate, migrate, and differentiate to settle into the internal granule layer. These processes are tightly regulated by a number of transcription factors and signaling pathways. T-Cell Factor/Lymphoid Enhancer-binding Factor (Tcf/Lef) are transcriptional effectors acting downstream of Wnt/β-catenin signaling. Although Tcf is transcriptionally active in the URL, neither its function(s) nor its developmental regulator(s) have been addressed in this area. The transcription factor BarH-like 1 (Barhl1) is expressed in committed GNPs located in areas devoid of Tcf transcriptional activity. The aims of this thesis were to investigate the functions of Tcf and of Barhl1 as regulators of GNPs development using amphibian as experimental model. The data presented in this work encompass a thorough analysis of the spatial and temporal expressions of key markers involved in GNP development in amphibian, and an investigation of Barhl1 and Tcf functions in this developmental process. Our gain and loss of function experiments, together with the transcriptomic analysis of Barhl1 depletion in the rhombomere 1 validate a key role for Tcf as a transcriptional activator of atoh1 and as an inducer of the URL territory, and for Barhl1 as a developmental inhibitor of Tcf activity allowing GNPs to exit the URL. We identified key genes inhibited by Barhl1 and involved in the maintenance of URL germinative zone
Goodwin, Laura Rose. "The Chromatin Remodelling Contributions of Snf2l in Cerebellar Granule Neuron Differentiation". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38201.
Texto completoChang, Chia-Hsiang y 張家祥. "Atoh1 requires primary cilia for the expansion of granule neuron progenitors by modulating centriolar satellites". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ww438x.
Texto completo國立陽明大學
分子醫學博士學位學程
107
In this thesis, we showed that how the cerebellar granular progenitor cells (GNPs) sensitize the Sonic hedgehog signaling (SHH) during cerebellar development. Importantly, by using the in vivo cerebellar electroporation and granular neuron purification, we found that the basic helix-loop-helix transcription factor, Atoh1, maintains the ciliated states of GNPs. As Atoh1 is required for the GNP neurogenesis, we identified that this activity is mediated through its regulation on the centriolar satellites, a multiple protein complex required for ciliogenesis. Next, we showed that Atoh1 is able to regulate the length of primary cilium in different cell lines.This property is possibly mediated through its transcriptional target, Gli2. Finally, we identified how Gli2 utilized the autophagy-dependent Ofd1 removal for the regulation on the ciliary length.
Wortham, Matthew. "The Role of Otx2 in Bypassing Restrictions of Hindbrain Progenitor Cell Proliferation and the Mechanisms of its Dysregulation in Medulloblastoma". Diss., 2012. http://hdl.handle.net/10161/6158.
Texto completoMedulloblastoma is the most common malignant brain tumor in children. The understanding of the genetic alterations in this tumor is emergent, and many such genetic driver events have yet to be functionally-characterized. Our studies have sought to understand the causes and consequences of OTX2 dysregulation in established medulloblastomas and in its putative cellular origins. Using a tumor genetic approach, we have uncovered frequent OTX2 copy number gains driving expression of this oncogene in a subset of medulloblastomas. However, OTX2 is frequently expressed in medulloblastomas independent of genomic copy number gain, and we thus sought to understand the transcriptional regulation of this gene in these tumors. We have found that chromatin accessibility, promoter DNA methylation, and activity of a distal downstream enhancer is distinct between OTX2-expressing and -nonexpressing medulloblastomas. Notably, autoregulation serves to maintain OTX2 expression in some medulloblastomas, whereas DNA methylation actively suppresses OTX2 in tumors not expressing this gene. Finally, we describe the effect of expressing Otx2 (the mouse homolog of OTX2) aberrantly in the developing mouse hindbrain, revealing that Otx2 disrupts spatiotemporal restrictions of neuronal progenitor cell proliferation. The effect of Otx2 in vivo is transient, with ectopically-proliferating cells give way to differentiated neurons. We found that OTX2 expression was not able to give rise to high penetrance medulloblastoma when combined with P53 deletion or double heterozygosity for P53 and PTEN. Thus, although Otx2 alters migration and proliferation dynamics of hindbrain neuronal progenitor cells, further studies are needed to identify the genetic alterations that cooperate with this oncogene to give rise to medulloblastoma.
Dissertation
"High Resolution Identification of Bioparticle Subpopulations with Electrophysical Properties". Doctoral diss., 2020. http://hdl.handle.net/2286/R.I.57025.
Texto completoDissertation/Thesis
Doctoral Dissertation Chemistry 2020
Capítulos de libros sobre el tema "Granule Neuron Progenitors"
Ocasio, Jennifer Karin. "Maintaining Cerebellar Granule Neuron Progenitors in Cell Culture". En Methods in Molecular Biology, 9–12. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2752-5_2.
Texto completoNanjangud, Gouri. "Conventional and Spectral Karyotyping of Murine Cerebellar Granule Neuron Progenitors". En Methods in Molecular Biology, 25–45. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2752-5_4.
Texto completoOcasio, Jennifer Karin. "Dissociation of Cerebellar Granule Neuron Progenitors for Culture, FACS, Transcriptomics, and Molecular Biology". En Methods in Molecular Biology, 3–7. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2752-5_1.
Texto completoOcasio, Jennifer Karin. "Proliferation Analysis of Cerebellar Granule Neuron Progenitors for Microcephaly Research, Using Immunofluorescent Staining and Flow Cytometry". En Methods in Molecular Biology, 13–23. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2752-5_3.
Texto completo