Tesis sobre el tema "GM-CSF"
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Bailie, Karen Elizabeth Margaret. "G-CSF and GM-CSF : effects on neonatal neutrophils". Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.482043.
Texto completoChevalier, Anne Sophie. "Utilisation thérapeutique du G-CSF et du GM-CSF en hématologie". Paris 5, 1993. http://www.theses.fr/1993PA05P248.
Texto completoHallsworth, Matthew Pearce. "GM-CSF and eosinophil survival in asthma". Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341883.
Texto completoBernstone, Laura. "Characterisation of HIV-1 infection and M-CSF and GM-CSF macrophages". Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572833.
Texto completoLin, Tony Wei Ting. "The role of GM-CSF/G-CSF & BKLF in the development of atherosclerosis". Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10407.
Texto completoMirabella, Fabio. "Regulation of the human IL-3/GM-CSF locus". Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487744.
Texto completoGrant, Olivia M. "GM-CSF Stress-Induced Priming of the Dendritic Cell". Ohio Dominican University Honors Theses / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1449522036.
Texto completoAdkins, Karissa Kathleen 1971. "Glucocorticoid regulation of GM-CSF in bronchial epithelial cells". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282844.
Texto completoAziz, Khalil Abdul. "Influence of GM-CSF and G-CSF on the mutual interactions between platelets and neutrophils". Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241473.
Texto completoOsborne, Cameron Stuart. "Transcriptional regulation of the GM-CSF gene in T lymphocytes /". Title page, contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pho81.pdf.
Texto completoYang, Nianji Eric. "THE ROLE OF GM-CSF IN MACROPHAGE POLARISATION IN RESPONSE TO TROPOELASTIN-COATED POLYETHYLENE IMPLANTS IN VIVO". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15866.
Texto completoEubank, Tim. "M-CSF and GM-CSF induce human monocytes to express either pro- or anti-angiogenic factors". The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1069772001.
Texto completoEubank, Timothy D. "M-CSF and GM-CSF induce human monocytes to express either pro- or anti-angiogenic factors". Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1069772001.
Texto completoTitle from first page of PDF file. Document formatted into pages; contains xx, 168 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Clay B. Marsh, Biochemistry Program. Includes bibliographical references (p. 150-168).
Pinder, Emma Muriel. "Does GM-CSF restore effective neutrophil function in critically ill patients?" Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3943.
Texto completoCARDONE, MARCO. "Il GM-CSF può promuovere il differenziamento di monociti umani in cellule dendritiche dotate di distinte proprietà immuno-stimolatorie e migratorie: ruolo dell'espressione del recettore del GM-CSF". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/546.
Texto completoMyeloid dendritic cells (DCs) and macrophages evolve from a common precursor. However, factors controlling monocyte differentiation toward DC or macrophage are poorly defined. We report that surface density of GM-CSF receptor (GM-CSFR) α subunit in human peripheral blood monocytes varies among donors. Although no correlation was found between the extent of GM-CSFR and monocyte differentiation into DC driven by GM-CSF and IL-4, GM-CSFR expression strongly influenced the generation of CD1a+ dendritic-like cells in the absence of IL-4. CD1a+ cells generated in the presence of GM-CSF express CD40, CD80, MHC I and II, DC-SIGN, MR, CCR5, and partially retain CD14 expression. Interestingly, they spontaneously induce the expansion of CD4+ and CD8+ allogeneic T lymphocytes producing IFN-gamma, and migrate toward CCL4 and CCL19. Upon stimulation with TLR ligands, they acquire the phenotypic features of mature DCs. In contrast, the allostimulatory capacity is not further increased upon LPS activation. However, by blocking LPS-induced IL-10, a higher T cell proliferative response and IL-12 production was observed. Interestingly, IL-23 secretion was not affected by endogenous IL-10. These results highlight the importance of GM-CSFR expression in monocytes for cytokine-induced DC generation and point to GM-CSF as a direct player in the generation of functionally distinct DCs.
Mikkelsen, Ipsen Johanna. "Kan onkolytiskt adenovirus armerat med GM-CSF fungera som behandling mot cancer?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-43026.
Texto completoLadds, Simon John. "The upregulation of neutrophil protein biosynthesis in response to GM-CSF stimulation". Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366718.
Texto completoRazanajaona, Diane. "Régulation de l'expression génique du GM-CSF dans les cellules hématopoiétiques humaines". Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX22022.
Texto completoRothchild, Alissa Chen. "Antimicrobial Roles for iNKT Cells and GM-CSF in Mycobacterium Tuberculosis Infection". Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11371.
Texto completoGoyal, Girija. "Novel Role of PPAR-Gamma in GM-CSF Induced Anti-Tumor Immunity". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226102.
Texto completoKühnle, Simone. "The reconstitution of immunocompetence by GM-CSF or IFN after pharmacological suppression". [S.l. : s.n.], 2001. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9073784.
Texto completoSylvain-Prévost, Stéphanie. "Implication de TAK1 dans la modulation des réponses du neutrophile humain au fMLP et au GM-CSF". Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6362.
Texto completoJasper, Melinda Jane. "Paracrine regulation of ovarian function by granulocyte-macrophage colony-stimulating factor (GM-CSF) & colony-stimulating factor-1 (CSF-1) /". Title page and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phj39.pdf.
Texto completoXu, Jian. "Selective reconstitution by GM-CSF of the immune response in human immunosuppressed cells". Konstanz, 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965669238.
Texto completoHellebrand, Eva. "Entwicklung von GM-CSF-produzierenden EBV-Vektoren für die Immuntherapie der B-CLL". Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12575.
Texto completoCowling, Randy T. "Effect of GM-CSF on RNA and protein in human peripheral blood granulocytes". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ36768.pdf.
Texto completoArcanjo, Katia Denise de Souza. "Organização molecular do espaço intercelular na sinalização do GM-CSF em sistemas hematopoeticos". [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317887.
Texto completoTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-01T08:59:37Z (GMT). No. of bitstreams: 1 Arcanjo_KatiaDenisedeSouza_D.pdf: 8227428 bytes, checksum: ce60d7dcab3f2fe523a6be9c914002b6 (MD5) Previous issue date: 2002
Resumo: O microambiente da medula óssea desempenha importância fundamental na proliferação e diferenciação das células progenitoras hematopoéticas bem como no controle do egresso dessas células para o sangue periférico. Embora moléculas da matriz extracelular, juntamente com citocinas, sejam cruciais na compartimentalização dos microambientes da medula óssea, ainda não se conhecem os pré-requesitos para que um determinado estroma possa sustentar a hematopoese. Usando uma linhagem celular (FDC-Pl) dependente de fator de crescimento, comparamos modelos experimentais de estromas periféricos e de medula óssea, que sustentam ou não a proliferação mielóide "in vitro". Observamos que todos os estromas produzem um grupo similar de hemopoetinas, incluindo o fator estimulador de colônias de macrófagos e granulócitos (GM-CSF), o qual pode ser liberado das monocamadas estromais, através de altas concentrações de sais, numa forma biologicamente ativa. Por outro lado, glicosaminoglicanos (GAGs) obtidos a partir desses estromas, exibiram uma capacidade de modulação da atividade biológica do GM-CSF variável, dependendo da concentração utilizada. Fibroblastos de pele, que não são capazes de sustentar a mielopoese "in vitro", sintetizam GAGs que podem inibir a atividade mielopoética de GM-CSF. Concluímos que, a qualidade dos glicoconjugados pericelulares dos estromas, presentes no microambiente local, é determinante para que um dado estroma seja capaz de sustentar a mielopoese, mesmo quando hemopoetinas biologicamente ativas são localmente produzidas. Os aspectos espaciais desse microambiente e as interações moleculares entre as células do estroma e progenitores mielóides foram investigados. Demonstramos que esse contato fisico pode disparar um "capping" de moléculas de superfície celular incluindo glicoconjugados de ácido siálico e proteoglicanos. Juntas, essas moléculas, potencialmente interativas com o GMCSF, geram um ambiente intercelular esfecífico, promovendo condições fisico-químicas requeri das para essa interação. A identificação da expressão dos HSPGs associados as superfícies celulares foi monitorada através de RT -PCR. Os estromas analisados mostraram expressão de mRNA para glipicam, betaglicam e sindecam-4. O tratamento das monocamadas estromais com PI-PLC (fosfolipase C) e tripsina branda, confinnou a presença de HSPGs de superfície celular (glipicam) e sindecam, respectivamente. Aproximadamente, 20% dos HSPGs obtidos, estão associados à membrana através de âncoras de GPI enquanto o restante, 80%, permanece integrado à membrana plasmática. Demonstramos que as moléculas marcadas com sulfato radioativo, deslocadas da superfície celular das células estromais após tratamento com tripsina branda, são capazes de aumentar a atividade biológica do GM-CSF, quando comparadas com aquelas deslocadas por PIPLC as quais não apresentaram diferenças significativas se comparadas com o controle. Esses resultados sugerem a existência de HSPGs transmembranares e associados via âncora de GPI nas superfícies das células estromais, e que, a atividade biológica de GM-CSF na proliferação de FDC-Pl "in vitro", é aumentada através de uma possível interação física entre o fator de crescimento e um HSPG transmembranar
Abstract: The bone marrow microenvironrnent plays an important role in promoting hematopoietic progenitor cell proliferation and differentiation, as well as their controlled release into the circulation. It has been shown that the extracellular matrix elements in combination with cytokines are crucial for compartmentalization of the bone marrow environrnent, but it is not clear which are the molecular and structural requirements for a given stroma to sustain hematopoiesis. Using the growth factor-dependent cell line FDC-Pl, we have compared in vitro experimental models of bone marrow and peripheral stromas, two of which sustain myeloid proliferation and one which does not. We have found that all the stromas produced a similar set of hemopoietins, including the GM-CSF, which could be released from the stromal cell layer in an active form by high-salt buffers. On the other hand, glycosaminoglycans (GAGs) obtained from stromas had variable concentration-dependent capacity to modulate the GM-CSF activity. The skin fibroblasts, which can not sustain myelopoieis in vitro, synthesized GAGs that could inhibit the myelopoiesis-promoting activity of GM-CSF produced by the same cells. We conclude that the quality of the stroma pericellular glycoconjugates, present in microenvironrnent, is determinant for the ability of a given stroma to sustain myelopoiesis, even when biologically active hemopoietins are locally produced. The spatial organization of this microenvironrnent and molecular interactions among stroma cells and myeloid progenitors was investigated, and we have shown that the physical intercellular contact triggers the capping of cell surface molecules, including sialylated glycoconjugates and proteoglycans. Together, they generated the specific intercellular environrnent, rich in molecules potentially interactive with GM-CSF, and providing the physicochemical conditions required for this interaction. We have partially assessed the identification of the core proteins of cell-associated HSPGs of the stromal cell lines monitoring their expression by RT-PCR. The assayed stromas expressed mRNA for glypican, syndecan-4 and betaglycan. The stromal layers treatment with PI-PLC and mild trypsin confirmed the presence of hydrophobic cell surface HSPG glypican and syndecan, respectively. About 20% of the HSPG are linked to membrane by glycosilphosphatidylinositol (GPI) anchor while the remainder, 80%, are integrated in the plasma membrane. We have shown that the 35 -s labeled molecules dislodged from stroma cell membranes by mild treatment with trypsin increased the biological activity of the GM-CSF, whilst those dislodged by phospholipase-C did noto These results suggested the existence of both transmembrane HSPG and GPI-HSPG and that the biological activity of GM-CSF in FDC-Pl proliferation, in vitro, is increased by a physical interaction between growth factor and transmembranar HSPG
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
Stomski, Frank Charles. "The molecular basis of IL-3, Il-5 and GM-CSF receptor activation /". Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs8766.pdf.
Texto completoPfeiffer, Hella [Verfasser] y Walburga [Akademischer Betreuer] Dieterich. "Bestimmung der Oberflächenmarker und des Aktivierungsgrades von CD14+ Zellen aus humanem Blut nach Stimulation und Reifung mit IL-4/GM-CSF oder IL-15/GM-CSF / Hella Pfeiffer. Gutachter: Walburga Dieterich". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1075838045/34.
Texto completoBaker, David Alan. "Mutational analysis of the proto-oncogenes c-fms and c-kit". Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362390.
Texto completoCuré, Hervé. "Intensification de la chimiotherapie neo-adjuvante du cancer du sein : impact sur la reponse et la survie et etude des cellules souches hematopoietiques peripheriques (doctorat : hemato-cancerologie)". Clermont-Ferrand 1, 1999. http://www.theses.fr/1999CLF1MM15.
Texto completoDE, GENTILE ALBANE. "Etude de l'expression et de la modulation par l'acide retinoique des recepteurs du gm-csf et de cytokines dans les leucemies aigues promyelocytaires. Production d'anticorps diriges contre le recepteur du gm-csf". Paris 6, 1994. http://www.theses.fr/1994PA066580.
Texto completoSzymanski, Silvia. "Evaluation of different approaches to enhancing arteriogenesis using isolated monocytes and GM-CSF treatment in an ischemic mouse hind limb model". Giessen : VVB Laufersweiler, 2006. http://geb.uni-giessen.de/geb/volltexte/2007/4335/index.html.
Texto completoFeil, Bertram. "Genexpression des Adaptorproteins Shc bei Patienten mit Juveniler Myelomonozytärer Leukämie (JMML) Charakterisierung neuer Spleißformen der SH2-Domäne von Shc /". [S.l. : s.n.], 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8937685.
Texto completoHouzet, Laurent. "Etude du rôle des séquences AU riches de l'ARNm du GM-CSF in vivo". Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211667.
Texto completoLICARI, VERONIQUE. "Maladie de kaposi localisee chez un sujet hiv negatif : action antitumorale du gm-csf". Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20131.
Texto completoKühnle, Simone. "The reconstitution of immunocompetence by GM-CSF or (IFN-g) [(IFN-gamma)] after pharmacological suppression". [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961227540.
Texto completoHarris, Robert John. "Studies of the production and function of GM-CSF in LTBMC and mature B cells". Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266492.
Texto completoFernandez, Marilyn Cecilia. "Mechanisms regulating GM-CSF and TNF-alpha induced IL-1(beta) gene expression in PMN /". The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942739808581.
Texto completoDeane, David Leslie. "The characterisation of a GM-CSF and IL-2 inhibitory protein encoded by Orf virus". Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23323.
Texto completoPaolini, Léa. "Impact de l’acide lactique sur le phénotype et le métabolisme des macrophages humains". Thesis, Angers, 2018. http://www.theses.fr/2018ANGE0036.
Texto completoIn established tumors, tumor-associated macrophages (TAM) orchestrate unresolving cancer-related inflammation (M1-related properties) and favor tumor development, metastasis and angiogenesis (M2-like properties). However, to date, the nature of the polarization factor(s) able to confer M1 and M2 functional properties to human macrophages remains unknown.Lactic acid (LA), a metabolite produced at high levels in most established tumors, can impact the phenotype and functions of cells present in the tumor microenvironment. In this study, we analyzed the impact of LA on the human monocyte differentiation. Results showed that LA skews monocytes (differentiated in the presence of GM-CSF) into macrophages (GM+LA-Mφ) exhibiting an atypical CD14high CD163high IL-10low IL-12low phenotype. Interestingly they harbor M1 and M2 phenotypic features, as assessed the production of a wide variety of inflammatory and growth factors and the expression of prototypic M2-like genes. A similar profile is induced by culturing monocytes with glycolytic human primary cancer cells. These effects of LA on macrophage polarization require the entry of lactate into the cells (via the monocarboxylate transporter 1) and its oxidation into pyruvate and are mediated via HIF-1α stabilization and autocrine M-CSF consumption by differentiating cells. These results identify tumor-derived LA as a missing link reconciling the M2-like features of TAM with their inflammatory properties. They also reinforce the interest of aerobic glycolysis inhibitors to modulate the functions of TAM
Robertson, Sarah A. "Granulocyte-macrophage colony stimulating factor (GM-CSF) : a paracrine regulator in the pre-implantation mouse uterus". Title page, abstract and contents only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phr6515.pdf.
Texto completoRajotte, Daniel. "Étude sur la signalisation intracellulaire et la relation structure fonction du récepteur pour le GM-CSF". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21506.pdf.
Texto completoKidger, Simone Verina. "The impact of the synovial environment and GM-CSF on the myeloid compartment in rheumatoid arthritis". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8012/.
Texto completoNataf, Éric. "Etude cytogenetique du myelome multiple : a propos de 49 patients ; interet de l'utilisation gm. - csf - il6 - il3". Lille 2, 1992. http://www.theses.fr/1992LIL2M180.
Texto completoOLAGNIER, VALERIE. "Essai multicentrique en double aveugle ou cho-cell-gm-csf dans les neuroblastomes de haut grade traites par double autogreffe medullaire". Lyon 1, 1989. http://www.theses.fr/1989LYO1M323.
Texto completoWeininger, Eva-Maria [Verfasser], Juan Manuel [Akademischer Betreuer] Maler, Jun Manuel [Gutachter] Maler y Philipp [Gutachter] Spitzer. "GM-CSF und M-CSF in Serum und Liquor bei der Alzheimer-Erkrankung / Eva-Maria Weininger ; Gutachter: Jun Manuel Maler, Philipp Spitzer ; Betreuer: Juan Manuel Maler". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1203377649/34.
Texto completoHüttinger, Cornelia. "Nonviraler Gentransfer des felinen Zytokin-Gens GM-CSF mittels Magnetofektion als neoadjuvante Immuntherapie beim Fibrosarkom der Katze". Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-89747.
Texto completoWalsch, Florian Markus. "Nonviraler Gentransfer des felinen Zytokin-Gens GM-CSF mittels Magnetofektion als neoadjuvante Immuntherapie beim Fibrosarkom der Katze". Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-147715.
Texto completoCREISSON, DUCRAY ANNE. "Lymphomes non-hodgkiniens agressifs du sujet age : resultat du protocole memid avec et sans rh-gm-csf". Nice, 1993. http://www.theses.fr/1993NICE6536.
Texto completo