Literatura académica sobre el tema "GluK1 receptors"
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Artículos de revistas sobre el tema "GluK1 receptors"
Chałupnik, Paulina, Alina Vialko, Darryl S. Pickering, Markus Hinkkanen, Stephanie Donbosco, Thor C. Møller, Anders A. Jensen et al. "Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype". International Journal of Molecular Sciences 23, n.º 15 (8 de agosto de 2022): 8797. http://dx.doi.org/10.3390/ijms23158797.
Texto completoJaremko, William, Zhen Huang, Nicholas Karl, Vincen D. Pierce, Janet Lynch y Li Niu. "A kainate receptor–selective RNA aptamer". Journal of Biological Chemistry 295, n.º 19 (11 de marzo de 2020): 6280–88. http://dx.doi.org/10.1074/jbc.ra119.011649.
Texto completoSheng, Nengyin, Yun Stone Shi y Roger A. Nicoll. "Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking". Proceedings of the National Academy of Sciences 114, n.º 5 (18 de enero de 2017): 1159–64. http://dx.doi.org/10.1073/pnas.1619253114.
Texto completoPollok, Stefan y Andreas Reiner. "Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization". Proceedings of the National Academy of Sciences 117, n.º 41 (30 de septiembre de 2020): 25851–58. http://dx.doi.org/10.1073/pnas.2007471117.
Texto completoJaremko, William J., Zhen Huang, Wei Wen, Andrew Wu, Nicholas Karl y Li Niu. "Identification and characterization of RNA aptamers: A long aptamer blocks the AMPA receptor and a short aptamer blocks both AMPA and kainate receptors". Journal of Biological Chemistry 292, n.º 18 (21 de marzo de 2017): 7338–47. http://dx.doi.org/10.1074/jbc.m116.774752.
Texto completoKoga, Kohei, Su-Eon Sim, Tao Chen, Long-Jun Wu, Bong-Kiun Kaang y Min Zhuo. "Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex". Journal of Neurophysiology 108, n.º 7 (1 de octubre de 2012): 1988–98. http://dx.doi.org/10.1152/jn.00453.2012.
Texto completoAnna Kaczor, Agnieszka, Christiane Kronbach, Klaus Unverferth, Kalevi Pihlaja, Kirsti Wiinamaki, Jari Sinkkonen, Urszula Kijkowska-Murak, Tomasz Wrobel, Tomasz Stachal y Dariusz Matosiuk. "Novel Non-Competitive Antagonists of Kainate GluK1/GluK2 Receptors". Letters in Drug Design & Discovery 9, n.º 10 (1 de diciembre de 2012): 891–98. http://dx.doi.org/10.2174/157018012804586978.
Texto completoAnna Kaczor, Agnieszka, Christiane Kronbach, Klaus Unverferth, Kalevi Pihlaja, Kirsti Wiinamaki, Jari Sinkkonen, Urszula Kijkowska-Murak, Tomasz Wrobel, Tomasz Stachal y Dariusz Matosiuk. "Novel Non-Competitive Antagonists of Kainate GluK1/GluK2 Receptors". Letters in Drug Design & Discovery 9, n.º 10 (24 de octubre de 2012): 891–98. http://dx.doi.org/10.2174/1570180811209050891.
Texto completoMasocha, Willias. "Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice". PeerJ 3 (22 de octubre de 2015): e1350. http://dx.doi.org/10.7717/peerj.1350.
Texto completoBartyzel, Agata, Agnieszka A. Kaczor, Ghodrat Mahmoudi, Ardavan Masoudiasl, Tomasz M. Wróbel, Monika Pitucha y Dariusz Matosiuk. "Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors". Molecules 27, n.º 8 (12 de abril de 2022): 2479. http://dx.doi.org/10.3390/molecules27082479.
Texto completoTesis sobre el tema "GluK1 receptors"
Carreno, Velazquez Thalia Lizbeth. "Structure-based drug discovery approaches to identify modulators of the Nrf2 pathway and glutamate receptors AMPA GluA2 and Kainate GluK1 and GluK2". Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/75046/.
Texto completoFachim, Helene Aparecida. "Estudo da expressão das subunidades GluR1 e GluR2 no hipocampo de ratos após lesão por NMDA e avaliação do efeito neuroprotetor da Parawixina 10". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-25032013-144441/.
Texto completoIt has been shown the involvement of glutamate, through different receptors, on the excitotoxic mechanisms which result on the neuronal death reported in most neurodegenerative disorders of the CNS. In addition, Parawixina 10 (Pwx 10) has been demonstrated to act as neuroprotective in models of injury regulating the glutamatergic neurotransmission through glutamate transporters. The aims of this work were: i) to study, in a time course (24h, 1, 2 and 4 weeks), the changes on the expression of AMPA receptors in rat hippocampus induced by NMDA intrahippocampal injection, and ii) to study the neuroprotective effect of Pwx 10 in this moldel. Male Wistar rats has been used, submitted to stereotaxic surgery for saline or NMDA microinjection into dorsal hippocampus. Some groups of animals were treated with Pwx 10 from 1h or 24h after NMDA. The behavioral test on Morris water maze (MWM) and the Nissl staining were performed for evaluating the extension and efficacy of the NMDA injury and the neuroprotective effect of the Pwx 10 . The expression of the receptors was analyzed by immunohistochemistry. The expression of GFAP and NeuN on the lesioned area has also been investigated by immunofluorescency. It was observed the impaiment of learning and memory functions in the MWM, and intense loss of neuronal cells and glial proliferation in CA1 that received the NMDA, confirming the efficiency of the injury by the agonist. We observed a time course of distinct changes on the expression of GluR1 and GluR2 subunits of AMPA receptors in hippocampus, which may be related to the complex mechanism triggered in response to NMDA injection resulting in a local injury and on the activation of neuronal plasticity. The treatment with Pwx 10 showed neuroprotective effect, being most pronounced when the toxin was administrated from 1h after NMDA.
Gitelman, Julian. "Synaptic incorporation of GluA1-containing AMPA receptors during memory processes". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110505.
Texto completoIl est généralement accepté que les modifications de la force synaptique sont à la base de l'apprentissage et la mémoire et que la force d'une synapse est largement régie par l'abondance et la distribution de récepteurs synaptiques, en particulier de récepteurs alpha-amino-3-hydroxy-5-méthyl-4- isoxazole propionate (récepteurs AMPA), qui interviennent dans la plupart des transmissions synaptiques rapides dans le cerveau. Les récepteurs AMPA contenant la sous-unité GluA1 sont incorporés dans la synapse suite à son activation et des modifications post-traductionnelles de l'extrémité carboxy-terminale influencent quelles protéines interagissent avec le récepteur et détermine si le récepteur est inséré ou retiré de la synapse. Des recherches in vitro ont découvert que la phosphorylation de trois résidus sérine contenus sur l'extrémité carboxy-terminale (Ser-818, Ser-831 et Ser-845) régie l'incorporation synaptique de GluA1; cependant, les recherches in vivo étudiant l'importance de ces sites de phosphorylation sur la formation de la mémoire à long terme est actuellement limitée à des études utilisant des « knock in ». Pour bloquer les interactions entre ces sites de phosphorylation et de leurs partenaires de liaison de manière inductible et temporellement sensibles, nous avons infusé des peptides d'interférence contenant ces résidus lors de la consolidation et la reconsolidation. Nous émettons l'hypothèse que si l'incorporation synaptique des récepteurs AMPA contenant GluA1 est nécessaire à la formation de la mémoire, et si cette incorporation exige les résidus contenus dans le peptide d'interférence, nous verrions une déficience dans l'expression de mémoire à long terme lorsque le peptide a été infusé au moment du conditionnement ou du rappel du souvenir.L'infusion du peptide d'interférence GluA1-CT, contenant les sérines Ser 831 et Ser-845, 1 heure avant le conditionnement de peur auditive n'a produit aucune altération dans l'expression de mémoire 24 heures plus tard. Cependant, l'infusion du peptide d'interférence GluA1-MPR, contenant la sérine Ser-818, 1 heure avant le conditionnement a produit une déficience dans l'expression de mémoire 24 heures plus tard. Nous n'avons pas observé d'altération dans l'expression de mémoire à long terme lorsque les deux peptides ont été infusés 1 heure avant la réactivation.
Teixidó, Viyuela Laura. "Factors sèrics en l’Esclerosi Lateral Amiotròfica. Modulació del receptor de glutamat de tipus NMDA GluN1/GluN2A". Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/79039.
Texto completoAmyotrophic lateral sclerosis (ALS) is a devastating neuromuscular disease, characterized by the selective degeneration of the superior motor neurons in the motor cortex and of the inferior motor neurons in the brain-stem and spinal cord. The familial form of the illness is associated with the mutation of the superoxide dismutase enzyme (SOD-1). This and other mutations accounts for fewer than 10% of cases; the rest, more than 90%, correspond to the sporadic form. In this study we tested the effect of sera from sporadic ALS patients and from mutated human SOD-1 (mSOD1 G93A) transgenic rats on N-methyl-D-aspartate receptors (NMDAR). We hypothesize that an endogenous excitotoxic factor is implicated in neuronal death in ALS, mediated by the activation of NMDAR noncanonical signalling pathways. Sera from ALS patients or healthy subjects were pretreated to inactivate complement pathways and dialysed to remove glutamate. Sera from mSOD1 G93A rats were obtained at different stages of the neurodegenerative progression. Sera from transgenic rats were also pretreated to eliminate complement system and glutamate. Immunoglobulins G (IgGs) from ALS patients and healthy subjects were obtained by affinity chromatography and dialyzed against phosphate-buffered saline. Human NMDAR were expressed in Xenopus laevis oocytes, and glutamate-induced currents were recorded using the two electrode voltage clamp technique. We observed that sera from sporadic ALS patients induced transient oscillatory currents in Xenopus oocytes expressing NMDAR with a total electric charge significantly higher than the electric charge carried by currents induced by sera from healthy subjects. The currents were inhibited by MK-801, a noncompetitive blocker of NMDAR. Results of sera from mSOD1 G93A transgenic rats were similar to those of sera from ALS patients; samples from patients with another type of neuromuscular disease did not exert this effect. IgG from ALS patients have a significant effect on NMDAR-injected oocytes and that response was doubled respect to the observed in the case of IgG from healthy subjects. Our data agree with the view that ALS patients sera contain some soluble factors that activates NMDAR, not opening directly the ionic conductance, but activating a non-canonical pathway.
Guo, Yanan [Verfasser] y M. [Akademischer Betreuer] Elstner. "Theoretical Investigation of Kainate Receptor GluK2 and Channelrhodopsin-2: Structure and Mechanism / Yanan Guo ; Betreuer: M. Elstner". Karlsruhe : KIT-Bibliothek, 2017. http://d-nb.info/1126036862/34.
Texto completoWarre, Ruth. "The role of the kainate receptor subunit GluK5 in the epileptiform activity induced by pilocarpine in vitro". Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432945.
Texto completoDachtler, James. "The role of the AMPA receptor subunit GluR1 and nitric oxide in experience-dependent plasticity and memory formation". Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54169/.
Texto completoKoesters, Andrew G. "Rab3A as a modulator of homeostatic synaptic plasticity". Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1409319870.
Texto completoNagarajan, Naveen. "Molecular mechanisms of AMPA and kainate receptor gating and its implication in synaptic transmission". Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965898768.
Texto completoCastro, Zavala Adriana 1988. "Effects of maternal separation with early weaning on cocaine addictive behaviour and consequences on neuroplasticity". Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670107.
Texto completoEl estrés en la etapa temprana de la vida se asocial con efectos cerebrales maladaptativos y duraderos. Dichas alteraciones pueden aumentar la probabilidad de desarrollar diversos trastornos psiquiátricos. Sin embargo, las consecuencias moleculares del estrés en la vida temprana son poco conocidas. En este trabajo evaluamos el impacto de la separación maternal con destete temprano (MSEW, por sus siglas en inglés) en diferentes fases de la autoadministración de cocaína, así como las posteriores alteraciones moleculares en regiones cerebrales asociadas al sistema de recompensa, en ratones machos y hembras. Nuestros resultados muestran que la MSEW afecta a los machos, mientras que las hembras parecen ser resistentes a este tipo de estrés. Los ratones separados maternalmente muestran un mayor porcentaje de adquisición, más consumo de cocaína y una menor capacidad para extinguir el comportamiento de autoadministración. Además, los análisis moleculares de las áreas cerebrales estudiadas revelan alteraciones inducidas por el sexo en la composición del receptor AMPA y cambios inducidos por la MSEW en la expresión de GluA1, GluA2, pCREB y CREB. La cocaína también altera la expresión de estas moléculas. Los resultados en conjunto sugieren que la MSEW induce alteraciones moleculares en áreas relacionadas con el procesamiento de la recompensa, potenciando la vulnerabilidad al comportamiento de búsqueda de cocaína y la depresión.
Libros sobre el tema "GluK1 receptors"
Wells, Elizabeth M. Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0091.
Texto completoBaker, Chris. The role of serine phosphorylation on the slow inactivation of the GluR1 Lurcher AMPA receptor. 2006.
Buscar texto completoCapítulos de libros sobre el tema "GluK1 receptors"
Kohda, Kazuhisa, Wataru Kakegawa y Michisuke Yuzaki. "Delta Glutamate Receptor (GluD1, GluD2)". En Encyclopedia of Signaling Molecules, 1345–52. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_642.
Texto completoKohda, Kazuhisa, Wataru Kakegawa y Michisuke Yuzaki. "Delta Glutamate Receptor (GluD1, GluD2)". En Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_642-1.
Texto completoLukas, Thomas J., Daniela V. Rosa, Luiz Alexandre V. Magno, Bruno R. Souza, Marco A. Romano-Silva, Hisao Masai, Kazuhisa Kohda et al. "Delta Glutamate Receptor (GluD1, GluD2)". En Encyclopedia of Signaling Molecules, 514–18. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_642.
Texto completoBruneau, Nadine y Pierre Szepetowski. "Magnetofection™ of NMDA Receptor Subunits GluN1 and GluN2A Expression Vectors in Non-Neuronal Host Cells". En Methods in Molecular Biology, 129–35. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7321-7_5.
Texto completoDoherty, A., A. Irving, G. L. Collingridge y J. M. Henley. "Localisation and Surface Expression of the AMPA Receptor Subunit GluR1 Using Green Fluorescent Protein and Anti-Peptide Antibodies". En Excitatory Amino Acids, 161–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03596-2_9.
Texto completoKhatib, Thabat, Berndt Müller y Peter McCaffery. "A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor". En Bioluminescence, 197–207. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2453-1_15.
Texto completoNisticò, Robert, Sheila Dargan, Stephen M. Fitzjohn, David Lodge, David E. Jane, Graham L. Collingridge y Zuner A. Bortolotto. "Chapter 2 Gluk1 Receptor Antagonists and Hippocampal Mossy Fiber Function". En International Review of Neurobiology, 13–27. Elsevier, 2009. http://dx.doi.org/10.1016/s0074-7742(09)85002-2.
Texto completoSanderson, D. J., M. A. Good, P. H. Seeburg, R. Sprengel, J. N. P. Rawlins y D. M. Bannerman. "Chapter 9 The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory". En Progress in Brain Research, 159–78. Elsevier, 2008. http://dx.doi.org/10.1016/s0079-6123(07)00009-x.
Texto completoKnoers, Nine V. A. M. y Elena N. Levtchenko. "Disorders of tubular electrolyte handling". En Oxford Textbook of Medicine, editado por John D. Firth, 5112–23. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0506.
Texto completoActas de conferencias sobre el tema "GluK1 receptors"
Hargrove-Wiley, Ebony, Daniel Valent, Demond Williams, Wendy Bindeman y Barbara Fingleton. "Abstract 2446: IL4 receptor-induced proliferation is mediated via Glut1 activity in metastatic breast cancer". En Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2446.
Texto completoBenammar, Sarra, Fatima Mraiche, Jensa Mariam Joseph y Katerina Gorachinova. "Glucose and Transferrin Liganded PLGA Nanoparticles Internalization in Non-Small Lung Cancer Cells". En Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0227.
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